                         SEQUENCE LISTING

<110>  Baylor College of Medicine
 
<120>  ONCOLYTIC VIROTHERAPY AND IMMUNOTHERAPY

<130>  BAYM.P0227WO

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(C5)-CD28TM,ICD-CD3Z CAR

<400>  1

Met Thr Arg Ala Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly 
1               5                   10                  15      


Ala Ala Thr Gly Ala His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser 
        35                  40                  45              


Gly Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln 
    50                  55                  60                  


Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly 
65                  70                  75                  80  


Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val 
                85                  90                  95      


Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala 
            100                 105                 110         


Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ala Pro Asp Ser Ser 
        115                 120                 125             


Gly Tyr Leu Val Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro 
                165                 170                 175     


Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser 
            180                 185                 190         


Thr Gly Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro 
        195                 200                 205             


Arg Thr Leu Ile Tyr Ser Thr Asn Ser Arg Ser Ser Gly Val Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr 
225                 230                 235                 240 


Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Tyr Met 
                245                 250                 255     


Gly Ser Gly Ile Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            260                 265                 270         


Gly Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Thr Arg 
        275                 280                 285             


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
    290                 295                 300                 


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
305                 310                 315                 320 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                325                 330                 335     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            340                 345                 350         


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                405                 410                 415     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            420                 425                 430         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        435                 440                 445             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    450                 455                 460                 


Ala Leu Pro Pro Arg 
465                 


<210>  2
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(E4)-CD28TM,ICD-CD3Z CAR

<400>  2

Met Thr Arg Ala Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly 
1               5                   10                  15      


Ala Ala Thr Gly Ala His Ser Gln Val Gln Leu Gln Gln Trp Gly Ala 
            20                  25                  30          


Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr 
        35                  40                  45              


Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr 
65                  70                  75                  80  


Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Thr Ala Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Met Gly Ile Asn Ser Gly Gly Tyr 
        115                 120                 125             


Leu Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
                165                 170                 175     


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Ser 
            180                 185                 190         


Tyr Tyr Pro Ser Trp Tyr Gln Gln Ile Pro Gly Gln Ala Pro Arg Thr 
        195                 200                 205             


Leu Ile Tyr Thr Thr Asn Ile Arg Ser Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Gly Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
225                 230                 235                 240 


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Met Leu Tyr Met Gly Ser 
                245                 250                 255     


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 
            260                 265                 270         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Thr Arg Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        355                 360                 365             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    370                 375                 380                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
385                 390                 395                 400 


Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  3
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(F1)-CD28TM,ICD-CD3Z CAR

<400>  3

Met Thr Arg Ala Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly 
1               5                   10                  15      


Ala Ala Thr Gly Ala His Ser Gln Val Gln Leu Val Glu Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Lys Pro Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser 
        35                  40                  45              


Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser 
65                  70                  75                  80  


Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met Gly Ala Asn Ser Gly Gly 
        115                 120                 125             


Tyr Leu Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly 
                165                 170                 175     


Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr 
            180                 185                 190         


Ser Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg 
        195                 200                 205             


Thr Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly 
225                 230                 235                 240 


Ala Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Tyr Met Gly 
                245                 250                 255     


Ser Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            260                 265                 270         


Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Thr Arg Phe 
        275                 280                 285             


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
    290                 295                 300                 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                405                 410                 415     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            420                 425                 430         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        435                 440                 445             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    450                 455                 460                 


Leu Pro Pro Arg 
465             


<210>  4
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 TMD

<400>  4

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  5
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 ICD

<400>  5

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3Z ICD

<400>  6

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3 linker

<400>  7

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  8
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIgG H leader

<400>  8

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  9

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Thr Arg 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(C5) LC-CDR1

<400>  10

Gly Leu Ser Ser Gly Ser Val Ser Thr Gly Tyr Tyr Pro Ser 
1               5                   10                  


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(C5) LC-CDR2

<400>  11

Ser Thr Asn Ser Arg Ser Ser 
1               5           


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(C5) LC-CDR3

<400>  12

Val Leu Tyr Met Gly Ser Gly Ile Ser Val 
1               5                   10  


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(C5) HC-CDR1

<400>  13

Ser Ser Ser Tyr Tyr Trp Gly 
1               5           


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(C5) HC-CDR2

<400>  14

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(C5) HC-CDR3

<400>  15

Tyr Ala Pro Asp Ser Ser Gly Tyr Leu Val Ala Phe Asp Ile 
1               5                   10                  


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(C5) VL

<400>  16

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Ser Thr Asn Ser Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Ile Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 
            100                 105                 110         


<210>  17
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(C5) VH

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Tyr Ala Pro Asp Ser Ser Gly Tyr Leu Val Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(E4) LC-CDR1

<400>  18

Gly Leu Ser Ser Gly Ser Val Ser Thr Ser Tyr Tyr Pro Ser 
1               5                   10                  


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(E4) LC-CDR2

<400>  19

Thr Thr Asn Ile Arg Ser Ser 
1               5           


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(E4) LC-CDR3

<400>  20

Met Leu Tyr Met Gly Ser Gly Ile Trp Val 
1               5                   10  


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(E4) HC-CDR1

<400>  21

Ser Gly Tyr Tyr Trp Ser 
1               5       


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(E4) HC-CDR2

<400>  22

Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(E4) HC-CDR3

<400>  23

Met Gly Ile Asn Ser Gly Gly Tyr Leu Tyr Gly Met Asp Val 
1               5                   10                  


<210>  24
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(E4) VL

<400>  24

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Ser 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Gln Ile Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Thr Thr Asn Ile Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Gly Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Met Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 
            100                 105                 110         


<210>  25
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(E4) VH

<400>  25

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Thr Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Gly Ile Asn Ser Gly Gly Tyr Leu Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(F1) LC-CDR1

<400>  26

Gly Leu Ser Ser Gly Ser Val Ser Thr Ser Tyr Tyr Pro Ser 
1               5                   10                  


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(F1) LC-CDR2

<400>  27

Ser Thr Asn Thr Arg Ser Ser 
1               5           


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(F1) LC-CDR3

<400>  28

Val Leu Tyr Met Gly Ser Gly Ile Trp Val 
1               5                   10  


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(F1) HC-CDR1

<400>  29

Ser Ser Asn Trp Trp Ser 
1               5       


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(F1) HC-CDR2

<400>  30

Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(F1) HC-CDR3

<400>  31

Met Gly Ala Asn Ser Gly Gly Tyr Leu Tyr Gly Met Asp Val 
1               5                   10                  


<210>  32
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(F1) VL

<400>  32

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Ser 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser 
            100                 105                 110         


<210>  33
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(F1) VH

<400>  33

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Ala Asn Ser Gly Gly Tyr Leu Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  34
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ad2 E1Adelta24

<400>  34

Met Arg His Ile Ile Cys His Gly Gly Val Ile Thr Glu Glu Met Ala 
1               5                   10                  15      


Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val Leu Ala Asp Asn Leu 
            20                  25                  30          


Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu His Glu Leu Tyr Asp 
        35                  40                  45              


Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu Glu Ala Val Ser Gln 
    50                  55                  60                  


Ile Phe Pro Glu Ser Val Met Leu Ala Val Gln Glu Gly Ile Asp Leu 
65                  70                  75                  80  


Phe Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu Pro Pro His Leu Ser 
                85                  90                  95      


Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu Gly Pro Val Ser Met 
            100                 105                 110         


Pro Asn Leu Val Pro Glu Val Ile Asp Pro Pro Ser Asp Asp Glu Asp 
        115                 120                 125             


Glu Glu Gly Glu Glu Phe Val Leu Asp Tyr Val Glu His Pro Gly His 
    130                 135                 140                 


Gly Cys Arg Ser Cys His Tyr His Arg Arg Asn Thr Gly Asp Pro Asp 
145                 150                 155                 160 


Ile Met Cys Ser Leu Cys Tyr Met Arg Thr Cys Gly Met Phe Val Tyr 
                165                 170                 175     


Ser Pro Val Ser Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
            180                 185                 190         


Ala Arg Pro Thr Arg Arg Pro Lys Leu Val Pro Ala Ile Leu Arg Arg 
        195                 200                 205             


Pro Thr Ser Pro Val Ser Arg Glu Cys Asn Ser Ser Thr Asp Ser Cys 
    210                 215                 220                 


Asp Ser Gly Pro Ser Asn Thr Pro Pro Glu Ile His Pro Val Val Pro 
225                 230                 235                 240 


Leu Cys Pro Ile Lys Pro Val Ala Val Arg Val Gly Gly Arg Arg Gln 
                245                 250                 255     


Ala Val Glu Cys Ile Glu Asp Leu Leu Asn Glu Ser Gly Gln Pro Leu 
            260                 265                 270         


Asp Leu Ser Cys Lys Arg Pro Arg Pro 
        275                 280     


<210>  35
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huIL-12p70

<400>  35

Met Gly His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Val Pro Gly Val Gly Val Pro Gly 
                325                 330                 335     


Val Gly Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            340                 345                 350         


Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        355                 360                 365             


Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    370                 375                 380                 


Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
385                 390                 395                 400 


Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                405                 410                 415     


Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            420                 425                 430         


Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
        435                 440                 445             


Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    450                 455                 460                 


Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
465                 470                 475                 480 


Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                485                 490                 495     


Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            500                 505                 510         


Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        515                 520                 525             


Val Met Ser Tyr Leu Asn Ala Ser 
    530                 535     


<210>  36
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSV1 TK

<400>  36

Met Ala Ser Tyr Pro Gly His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Glu Ala Thr Glu Val Arg Pro Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Ile Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  37

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  38
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1(H12_gl) minibody

<400>  38

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Gly His Gly Tyr Ser Tyr Gly Ala Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr 
145                 150                 155                 160 


Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser 
                165                 170                 175     


Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp 
            180                 185                 190         


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn 
        195                 200                 205             


Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
    210                 215                 220                 


Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu 
225                 230                 235                 240 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Tyr 
                245                 250                 255     


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Glu Ala Lys Ser 
            260                 265                 270         


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Gly Gly Gly Gly Ser Tyr Pro Tyr Asp Val Pro Asp 
            500                 505                 510         


Tyr Ala Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Tyr Pro Tyr 
        515                 520                 525             


Asp Val Pro Asp Tyr Ala 
    530                 


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1(H12_gl) LC-CDR1

<400>  39

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1(H12_gl) LC-CDR2

<400>  40

Gly Asn Ser Asn Arg Pro Ser 
1               5           


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1(H12_gl) LC-CDR3

<400>  41

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Tyr Val Val 
1               5                   10              


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1(H12_gl) HC-CDR1

<400>  42

Ser Tyr Ala Ile Ser 
1               5   


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1(H12_gl) HC-CDR2

<400>  43

Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1(H12_gl) HC-CDR3

<400>  44

Ser Gly His Gly Tyr Ser Tyr Gly Ala Phe Asp Tyr 
1               5                   10          


<210>  45
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1(H12_gl) VL

<400>  45

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu 
    


<210>  46
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1(H12_gl) VH

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly His Gly Tyr Ser Tyr Gly Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  47
<211>  3750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HER2(C5)-CD28TM,ICD-CD3Z CAR

<400>  47
aagttcagat caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct       60

gtggtaagca gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg      120

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt      180

ccccagatgc ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc      240

cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc      300

ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc cctcactcgg      360

cgcgccagtc ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt      420

gcagttgcat ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga      480

ctacccgtca gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc      540

agggaccacc gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg      600

attgtctagt gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc      660

tctgtatctg gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg      720

ggagacgtcc cagggacttc gggggccgtt tttgtggccc gacctgagtc ctaaaatccc      780

gatcgtttag gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga      840

gacgagaacc taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga      900

agccgcgccg cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg      960

tttctgtatt tgtctgaaaa tatgggcccg ggctagcctg ttaccactcc cttaagtttg     1020

accttaggtc actggaaaga tgtcgagcgg atcgctcaca accagtcggt agatgtcaag     1080

aagagacgtt gggttacctt ctgctctgca gaatggccaa cctttaacgt cggatggccg     1140

cgagacggca cctttaaccg agacctcatc acccaggtta agatcaaggt cttttcacct     1200

ggcccgcatg gacacccaga ccaggtcccc tacatcgtga cctgggaagc cttggctttt     1260

gacccccctc cctgggtcaa gccctttgta caccctaagc ctccgcctcc tcttcctcca     1320

tccgccccgt ctctccccct tgaacctcct cgttcgaccc cgcctcgatc ctccctttat     1380

ccagccctca ctccttctct aggcgccccc atatggccat atgagatctt atatggggca     1440

cccccgcccc ttgtaaactt ccctgaccct gacatgacaa gagttactaa cagcccctct     1500

ctccaagctc acttacaggc tctctactta gtccagcacg aagtctggag acctctggcg     1560

gcagcctacc aagaacaact ggaccgaccg gtggtacctc acccttaccg agtcggcgac     1620

acagtgtggg tccgccgaca ccagactaag aacctagaac ctcgctggaa aggaccttac     1680

acagtcctgc tgaccacccc caccgccctc aaagtagacg gcatcgcagc ttggatacac     1740

gccgcccacg tgaaggctgc cgaccccggg ggtggaccat gactcgagcc atggattgga     1800

tctggcgcat cctgtttctc gtgggagctg ccacaggcgc ccattctcag gttcagctgc     1860

aagagtctgg ccctggcctg gtcaagccta gcgaaacact gagcctgacc tgtaccgtgt     1920

ctggcggcag catcagcagc agctcttact actggggctg gatcagacag cctcctggca     1980

aaggcctgga atggatcggc tccatctact acagcggcag cacctactac aaccccagcc     2040

tgaagtccag agtgaccatc agcgtggaca ccagcaagaa ccagttctcc ctgaagctga     2100

gcagcgtgac agccgccgat acagccgtgt actactgtgc cagatacgcc cctgatagca     2160

gcggctacct ggtggccttt gatatctggg gccagggcac aatggtcacc gtttctagcg     2220

gaggcggagg ttctggtggc ggaggaagtg gcggcggagg atctcagaca gtggtcacac     2280

aagagcccag cttctccgtg tctcctggcg gaacagtgac cctgacatgt ggccttagct     2340

ctggctctgt gtccaccggc tactacccca gctggtatca gcagacacct ggacaggccc     2400

ctcggacact gatctacagc accaacagca gatccagcgg cgtgcccgat agattcagcg     2460

gctctatcct gggcaacaag gccgcactga caatcacagg cgctcaggcc gatgacgaga     2520

gcgactacta ctgcgtgctg tacatgggca gcggcatctc cgtttttggc ggaggcacaa     2580

agctgaccgt gctgggatcc gaaccaaaga gttgcgacaa aacacacacc tgccctacgc     2640

gtttttgggt gctcgtggtg gtgggtggcg tgctcgcttg ctactcactt ctggtgaccg     2700

tagcgtttat cattttttgg gtcaggagca agcgatcccg cctattgcac agcgactaca     2760

tgaacatgac cccccggcgc cccgggccaa cccggaagca ctaccagcca tatgcgcctc     2820

cccgcgattt cgcagcgtat cggtcccggg tcaaattttc acggtccgct gacgccccgg     2880

cctatcaaca gggccagaat cagctgtata atgaattaaa cctcggtaga cgcgaggagt     2940

acgacgtcct cgacaagaga agggggcgcg acccagagat gggaggcaaa ccgcagcgca     3000

ggaagaatcc acaggagggc ctgtacaacg aattacagaa ggacaagatg gcagaggcct     3060

acagcgagat aggaatgaag ggtgaaaggc gtcgtggaaa gggccacgat gggctttacc     3120

agggcctaag tactgccaca aaagatacgt atgacgcgct gcatatgcaa gccctccccc     3180

ccaggtaagc atgcaacctc gatccggatt agtccaattt gttaaagaca ggatatcagt     3240

ggtccaggct ctagttttga ctcaacaata tcaccagctg aagcctatag agtacgagcc     3300

atagataaaa taaaagattt tatttagtct ccagaaaaag gggggaatga aagaccccac     3360

ctgtaggttt ggcaagctag cttaagtaac gccattttgc aaggcatgga aaaatacata     3420

actgagaata gagaagttca gatcaaggtc aggaacagat ggaacagctg aatatgggcc     3480

aaacaggata tctgtggtaa gcagttcctg ccccggctca gggccaagaa cagatggaac     3540

agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc     3600

aagaacagat ggtccccaga tgcggtccag ccctcagcag tttctagaga accatcagat     3660

gtttccaggg tgccccaagg acctgaaatg accctgtgcc ttatttgaac taaccaatca     3720

gttcgcttct cgcttctgtt cgcgcgcttc                                      3750


<210>  48
<211>  3744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HER2(E4)-CD28TM,ICD-CD3Z CAR

<400>  48
aagttcagat caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct       60

gtggtaagca gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg      120

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt      180

ccccagatgc ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc      240

cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc      300

ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc cctcactcgg      360

cgcgccagtc ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt      420

gcagttgcat ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga      480

ctacccgtca gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc      540

agggaccacc gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg      600

attgtctagt gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc      660

tctgtatctg gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg      720

ggagacgtcc cagggacttc gggggccgtt tttgtggccc gacctgagtc ctaaaatccc      780

gatcgtttag gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga      840

gacgagaacc taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga      900

agccgcgccg cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg      960

tttctgtatt tgtctgaaaa tatgggcccg ggctagcctg ttaccactcc cttaagtttg     1020

accttaggtc actggaaaga tgtcgagcgg atcgctcaca accagtcggt agatgtcaag     1080

aagagacgtt gggttacctt ctgctctgca gaatggccaa cctttaacgt cggatggccg     1140

cgagacggca cctttaaccg agacctcatc acccaggtta agatcaaggt cttttcacct     1200

ggcccgcatg gacacccaga ccaggtcccc tacatcgtga cctgggaagc cttggctttt     1260

gacccccctc cctgggtcaa gccctttgta caccctaagc ctccgcctcc tcttcctcca     1320

tccgccccgt ctctccccct tgaacctcct cgttcgaccc cgcctcgatc ctccctttat     1380

ccagccctca ctccttctct aggcgccccc atatggccat atgagatctt atatggggca     1440

cccccgcccc ttgtaaactt ccctgaccct gacatgacaa gagttactaa cagcccctct     1500

ctccaagctc acttacaggc tctctactta gtccagcacg aagtctggag acctctggcg     1560

gcagcctacc aagaacaact ggaccgaccg gtggtacctc acccttaccg agtcggcgac     1620

acagtgtggg tccgccgaca ccagactaag aacctagaac ctcgctggaa aggaccttac     1680

acagtcctgc tgaccacccc caccgccctc aaagtagacg gcatcgcagc ttggatacac     1740

gccgcccacg tgaaggctgc cgaccccggg ggtggaccat gactcgagcc atggattgga     1800

tctggcgcat cctgtttctc gtgggagctg ccacaggcgc ccattctcag gttcagctgc     1860

aacagtgggg agccggactg ctgaagccta gcgaaacact gagcctgacc tgtgccgtgt     1920

acggcggcag ctttagcggc tactactggt cctggatcag acagcctcct ggcaaaggcc     1980

tggaatggat cggcgagatc aatcacagcg gcagcaccaa ctacaacccc agcctgaagt     2040

ccagagtgac catcagcgtg gacaccagca agaaccagtt ctccctgaag ctgagcagcg     2100

tgaccacagc cgataccgcc gtgtactact gtgcccggat gggcatcaat agcggcggct     2160

acctgtacgg catggatgtg tggggacagg gcaccaccgt gacagtttct agcggaggcg     2220

gaggttctgg tggcggagga agtggcggcg gaggatctca gacagtggtc acacaagagc     2280

ccagcttctc cgtgtctcct ggcggaacag tgaccctgac atgtggcctt agcagcggct     2340

ctgtgtccac cagctactac cctagctggt atcagcagat ccccggacag gcccctcgga     2400

cactgatcta caccaccaac atcagatcca gcggcgtgcc cgatagattc ggcggatcta     2460

tcctgggcaa caaggccgca ctgacaatca caggtgccca ggccgaggac gagtccgact     2520

actactgcat gctgtacatg ggcagcggca tctgggtttt cggcggaggc acaaagctga     2580

ccgttctggg atccgaacca aagagttgcg acaaaacaca cacctgccct acgcgttttt     2640

gggtgctcgt ggtggtgggt ggcgtgctcg cttgctactc acttctggtg accgtagcgt     2700

ttatcatttt ttgggtcagg agcaagcgat cccgcctatt gcacagcgac tacatgaaca     2760

tgaccccccg gcgccccggg ccaacccgga agcactacca gccatatgcg cctccccgcg     2820

atttcgcagc gtatcggtcc cgggtcaaat tttcacggtc cgctgacgcc ccggcctatc     2880

aacagggcca gaatcagctg tataatgaat taaacctcgg tagacgcgag gagtacgacg     2940

tcctcgacaa gagaaggggg cgcgacccag agatgggagg caaaccgcag cgcaggaaga     3000

atccacagga gggcctgtac aacgaattac agaaggacaa gatggcagag gcctacagcg     3060

agataggaat gaagggtgaa aggcgtcgtg gaaagggcca cgatgggctt taccagggcc     3120

taagtactgc cacaaaagat acgtatgacg cgctgcatat gcaagccctc ccccccaggt     3180

aagcatgcaa cctcgatccg gattagtcca atttgttaaa gacaggatat cagtggtcca     3240

ggctctagtt ttgactcaac aatatcacca gctgaagcct atagagtacg agccatagat     3300

aaaataaaag attttattta gtctccagaa aaagggggga atgaaagacc ccacctgtag     3360

gtttggcaag ctagcttaag taacgccatt ttgcaaggca tggaaaaata cataactgag     3420

aatagagaag ttcagatcaa ggtcaggaac agatggaaca gctgaatatg ggccaaacag     3480

gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg gaacagctga     3540

atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag ggccaagaac     3600

agatggtccc cagatgcggt ccagccctca gcagtttcta gagaaccatc agatgtttcc     3660

agggtgcccc aaggacctga aatgaccctg tgccttattt gaactaacca atcagttcgc     3720

ttctcgcttc tgttcgcgcg cttc                                            3744


<210>  49
<211>  3747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HER2(F1)-CD28TM,ICD-CD3Z CAR

<400>  49
aagttcagat caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct       60

gtggtaagca gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg      120

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt      180

ccccagatgc ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc      240

cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc      300

ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc cctcactcgg      360

cgcgccagtc ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt      420

gcagttgcat ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga      480

ctacccgtca gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc      540

agggaccacc gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg      600

attgtctagt gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc      660

tctgtatctg gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg      720

ggagacgtcc cagggacttc gggggccgtt tttgtggccc gacctgagtc ctaaaatccc      780

gatcgtttag gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga      840

gacgagaacc taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga      900

agccgcgccg cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg      960

tttctgtatt tgtctgaaaa tatgggcccg ggctagcctg ttaccactcc cttaagtttg     1020

accttaggtc actggaaaga tgtcgagcgg atcgctcaca accagtcggt agatgtcaag     1080

aagagacgtt gggttacctt ctgctctgca gaatggccaa cctttaacgt cggatggccg     1140

cgagacggca cctttaaccg agacctcatc acccaggtta agatcaaggt cttttcacct     1200

ggcccgcatg gacacccaga ccaggtcccc tacatcgtga cctgggaagc cttggctttt     1260

gacccccctc cctgggtcaa gccctttgta caccctaagc ctccgcctcc tcttcctcca     1320

tccgccccgt ctctccccct tgaacctcct cgttcgaccc cgcctcgatc ctccctttat     1380

ccagccctca ctccttctct aggcgccccc atatggccat atgagatctt atatggggca     1440

cccccgcccc ttgtaaactt ccctgaccct gacatgacaa gagttactaa cagcccctct     1500

ctccaagctc acttacaggc tctctactta gtccagcacg aagtctggag acctctggcg     1560

gcagcctacc aagaacaact ggaccgaccg gtggtacctc acccttaccg agtcggcgac     1620

acagtgtggg tccgccgaca ccagactaag aacctagaac ctcgctggaa aggaccttac     1680

acagtcctgc tgaccacccc caccgccctc aaagtagacg gcatcgcagc ttggatacac     1740

gccgcccacg tgaaggctgc cgaccccggg ggtggaccat gactcgagcc atggattgga     1800

tctggcgcat cctgtttctc gtgggagctg ccacaggcgc ccattctcag gttcagctgg     1860

tggaatctgg ccctggcctg gttaagccta gcggcacact gtctctgacc tgtgctgtgt     1920

ctggcggcag catcagcagc agcaattggt ggtcttgggt ccgacagcct cctggcaaag     1980

gcctggaatg gatcggcgag atctaccaca gcggcagcac caactacaac cccagcctga     2040

agtccagagt gaccatcagc gtggacacca gcaagaacca gttctccctg aagctgagca     2100

gcgtgacagc cgccgataca gccgtgtact actgtgccag aatgggagcc aatagcggcg     2160

gctacctgta cggcatggat gtgtggggac agggcaccac cgtgacagtt tctagcggag     2220

gcggaggttc tggtggcgga ggaagtggcg gcggaggatc tcagacagtg gtcacacaag     2280

agcccagctt ctccgtgtct cctggcggaa cagtgaccct gacatgtggc cttagcagcg     2340

gctctgtgtc taccagctac tacccctcct ggtatcagca gacccctgga caggctcccc     2400

ggacactgat ctactccacc aacaccagat ccagcggcgt gcccgataga ttctccggct     2460

ctatcctggg caacaaggcc gcactgacaa tcacaggcgc tcaggccgat gacgagagcg     2520

actactactg cgtgctgtac atgggcagcg gcatctgggt tttcggcgga ggcacaaagc     2580

tgaccgttct gggatccgaa ccaaagagtt gcgacaaaac acacacctgc cctacgcgtt     2640

tttgggtgct cgtggtggtg ggtggcgtgc tcgcttgcta ctcacttctg gtgaccgtag     2700

cgtttatcat tttttgggtc aggagcaagc gatcccgcct attgcacagc gactacatga     2760

acatgacccc ccggcgcccc gggccaaccc ggaagcacta ccagccatat gcgcctcccc     2820

gcgatttcgc agcgtatcgg tcccgggtca aattttcacg gtccgctgac gccccggcct     2880

atcaacaggg ccagaatcag ctgtataatg aattaaacct cggtagacgc gaggagtacg     2940

acgtcctcga caagagaagg gggcgcgacc cagagatggg aggcaaaccg cagcgcagga     3000

agaatccaca ggagggcctg tacaacgaat tacagaagga caagatggca gaggcctaca     3060

gcgagatagg aatgaagggt gaaaggcgtc gtggaaaggg ccacgatggg ctttaccagg     3120

gcctaagtac tgccacaaaa gatacgtatg acgcgctgca tatgcaagcc ctccccccca     3180

ggtaagcatg caacctcgat ccggattagt ccaatttgtt aaagacagga tatcagtggt     3240

ccaggctcta gttttgactc aacaatatca ccagctgaag cctatagagt acgagccata     3300

gataaaataa aagattttat ttagtctcca gaaaaagggg ggaatgaaag accccacctg     3360

taggtttggc aagctagctt aagtaacgcc attttgcaag gcatggaaaa atacataact     3420

gagaatagag aagttcagat caaggtcagg aacagatgga acagctgaat atgggccaaa     3480

caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag atggaacagc     3540

tgaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag     3600

aacagatggt ccccagatgc ggtccagccc tcagcagttt ctagagaacc atcagatgtt     3660

tccagggtgc cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt     3720

cgcttctcgc ttctgttcgc gcgcttc                                         3747


<210>  50
<211>  30590
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HDAdIL12p70_TK_aPD-L1

<400>  50
aaacatcatc aataatatac cttattttgg attgaagcca atatgataat gagggggtgg       60

agtttgtgac gtggcgcggg gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag      120

tgtgatgttg caagtgtggc ggaacacatg taagcgacgg atgtggcaaa agtgacgttt      180

ttggtgtgcg ccggtgtaca caggaagtga caattttcgc gcggttttag gcggatgttg      240

tagtaaattt gggcgtaacc gagtaagatt tggccatttt cgcgggaaaa ctgaataaga      300

ggaagtgaaa tctgaataat tttgtgttac tcatagcgcg taatatttgt ctagggccgc      360

ggggactttg accgtttacg tggagactcg cccaggtgtt tttctcaggt gttttccgcg      420

ttccgggtca aagttggcgt tttgatatca agcttatcga taccgtaaac aagtctttaa      480

ttcaagcaag actttaacaa gttaaaagga gcttatgggt aggaagtagt gttatgatgt      540

atgggcataa agggttttaa tgggatagtg aaaatgtcta taataatact taaatggctg      600

cccaatcacc tacaggattg atgtaaacat ggaaaaggtc aaaaacttgg gtcactaaaa      660

tagatgatta atggagagga tgaggttgat agttaaatgt agataagtgg tcttattctc      720

aataaaaatg tgaacataag gcgagtttct acaaagatgg acaggactca ttcatgaaac      780

agcaaaaact ggacatttgt tctaatcttt gaagagtatg aaaaattcct attttaaagg      840

taaaacagta actcacagga aataccaacc caacataaaa tcagaaacaa tagtctaaag      900

taataaaaat caaacgtttg cacgatcaaa ttatgaatga aattcactac taaaattcac      960

actgattttg tttcatccac agtgtcaatg ttgtgatgca tttcaattgt gtgacacagg     1020

cagactgtgg atcaaaagtg gtttctggtg cgacttactc tcttgagtat acctgcagtc     1080

ccctttctta agtgtgttaa aaaaaaaggg ggatttcttc aattcgccaa tactctagct     1140

ctccatgtgc tttctaggaa acaagtgtta acccacctta tttgtcaaac ctagctccaa     1200

aggacttttg actccccaca aaccgatgta gctcaagaga gggtatctgt caccagtatg     1260

tatagtgaaa aaagtatccc aagtcccaac agcaattcct aaaaggagtt tatttaaaaa     1320

accacacaca cctgtaaaat aagtatatat cctccaaggt gactagtttt aaaaaaacag     1380

tattggcttt gatgtaaagt actagtgaat atgttagaaa aatctcactg taaccaagtg     1440

aaatgaaagc aagtatggtt tgcagagatt caaagaaaat ataagaaaac ctactgttgc     1500

cactaaaaag aatcatatat taaatatact cacacaatag ctcttcagtc tgataaaatc     1560

tacagtcata ggaatggatc tatcactatt tctattcagt gctttgatgt aatccagcag     1620

gtcagcaaag aatttatagc cccccttgag cacacagagg gctacaatgt gatggcctcc     1680

catctccttc atcacatctc gagcaagacg ttcagtccta cagaaataaa atcaggaatt     1740

taatagaaag tttcatacat taaactttat aacaaacacc tcttagtcat taaacttcca     1800

caccaacctg ggcaatatag tgagacccca tgcctgcaaa aaaaaaaaaa ttagccaggc     1860

atggtagcat gtacctgtag tcccagctac ttgagaggtg aggtgggaaa atcactttag     1920

tgcaggatgt tgaggctgga gtgaactgtg attgtgccac tgcactccag cctggacaat     1980

agagcaagac cttgtctcaa aaaaatgcat taaaaatttt ttttaaatct tccacgtatc     2040

acatcctttg ccctcatgtt tcataaggta aaaaatttga taccttcaaa aaaaccaagc     2100

ataccactat cataattttt tttaaatgca aataaaaaca agataccatt ttcacctatc     2160

agactggcag gttctgatta aatgaaattt tctggataat atacaatatt aagagagact     2220

gtagaaactg ggccagtggc tcatgcctgt aatcccagca ctttgggagg ctgggtaaca     2280

tggcgaaccc tgtttctaca aaataaaaat attagctggg agtggtggcg cacacctata     2340

gtcccagcta ctcaggaggc tgaggtggaa ggatcgcttg aacccaggag gttgagactg     2400

cagtgaactg tgatcattct gctgcactgc accccagcct gggcaacaga gaccttgtct     2460

caaaaaaaaa aaaaaaagag acaaattgtg aagagaaagg tactctcata taacatcagg     2520

agtataaaat gattcaactt cttagaggaa aatttggcaa taccaaaata ttcaataaac     2580

tctttcccct tgacccagaa attccacttg aataaagctg aacaagtacc aaacatgtaa     2640

aagaatgttt cttctagtac agtcggtaag aacaaaatag tgtctatcaa tagtggactg     2700

gttaaatcag ttatggtatc tccataagac agaatgctat gcaaccttta aaatatatta     2760

gatagctcta gacacactaa tattaaaagt gtccaataac atttaaaact atactcatac     2820

gttaaaatat aaatgtatat atgtactttt gcatatagta tacatgcata ggccagtgct     2880

tgagaagaaa tgtgtacaga aggctgaaag gagagaactt tagtcttctt gtttatggcc     2940

tccatagtta gaatatttta taacacaaat attttgatat tataatttta aaataaaaac     3000

acagaatagc cagacataca atgcaagcat tcaataccag gtaaggtttt tcactgtaat     3060

tgacttaaca gaaaattttc aagctagatg tgcataataa taaaaatctg accttgcctt     3120

catgtgattc agccccagtc cattaccctg tttaggactg agaaatgcaa gactctggct     3180

agagttcctt cttccatctc ccttcaatgt ttactttgtt ctggtcccta cagagtccca     3240

ctataccaca actgatacta agtaattagt aaggccctcc tcttttattt ttaataaaga     3300

agattttaga aagcatcagt tatttaataa gttggcctag tttatgttca aatagcaagt     3360

actcagaaca gctgctgatg tttgaaatta acacaagaaa aagtaaaaaa cctcatttta     3420

agatcttact tacctgtcca taattagtcc atgaggaata aacacccttt ccaaatcctc     3480

agcataatga ttaggtatgc aaaataaatc aaggtcataa cctggttcat catcactaat     3540

ctgaaaaaga aatatagctg tttcaatgag agcattacag gatacaaaca tttgattgga     3600

ttaagatgtt aaaaaataac cttagtctat cagagaaatt taggtgtaag atgatattag     3660

taactgttaa ctttgtaggt atgataatga attatgtaag aaaacaacag gccgggcggg     3720

ttggttcaca cgtgtaatcc cagcactttg ggaggctgag gcaggcagac tgcctgagct     3780

caggagttcg agaccagcct gggcaacacg gtgaaatccc gtctctacta aaaatacaaa     3840

aaaattagcc gggtgtggtg acacatgcct gtagtcccag ctacttggga ggctgaggca     3900

ggagaatcac ttgaacctgg gaggtgaagg ttgcagtgag ccaagatggc accacttcac     3960

tccagcctgg gaaacagagc aagactctgt ctctgagctg agatggcacc acttcactcc     4020

agcctgggaa acagagcaag actctgtctc aaaaaaaaca aaacacacaa acaaaaaaac     4080

aggctgggcg cggtggctca cgcctgtaat cccagcactt tgggaggccg aggcgggtgg     4140

atcacctgag gtcaggagtt ccagaccagc cttgtcaaca tggtgaaacc tccccccgcc     4200

gtctctacta aaaatacaaa aattagccag gcgtggtggc aggagcctgt aatcccagct     4260

acttgggagg ctgaggcagg agaatcgctt gtacccagaa ggcagaggtt gcactgagct     4320

gagatggcac cattgcactc cagcctgggg gacaagagcg agatttcgtc tttaaaaaac     4380

aaaaacaaaa caaaaaacca tgtaactata tgtcttagtc atcttagtca agaatgtaga     4440

agtaaagtga taagatatgg aatttccttt aggtcacaaa gagaaaaaga aaaattttaa     4500

agagctaaga caaacgcagc aaaatcttta tatttaataa tattctaaac atgggtgatg     4560

aacatacggg tattcattat actattctct ccacttttga gtatgtttga aaatttagta     4620

aaacaagttt taacacactg tagtctaaca agataaaata tcacactgaa caggaaaaac     4680

tggcatggtg tggtggctca cacttgtaat cccagtgctt tgggaggctg agacaggaga     4740

gttgcttgag gccaggagtt caagaccgac atggggaatg tagcaagacc ccgtccctac     4800

aaaaaacttt gtaaaaattt gccaggtatg gtggtgcata cctgtagtcc cagctactcg     4860

ggaggcggag gcagaaggaa tcacttgagc ccaggagttt gaggctgcag tgagctacga     4920

tcataccaca gcactccagc gtggacaaca gagtaagacc ctatctcaaa aacaaaacaa     4980

aacaaaacaa acaaaaaaaa ccacaagaaa aactgctggc tgatgcagcg gctcatgcct     5040

gtaatcccag tattttggga ggcccaggtg ggcgtatcac ctgaggtcag gagttagaga     5100

ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaaatt agccaggcat     5160

gtggcacgcg cctgtagtcc cagttactgg gaggctgaag caggaggatc acctgagccc     5220

gggaggtgga ggttgcagtg agccgagatc acaccactgc actccagcct gggtgacaca     5280

gcaataccct acctcaaaat aaaaaagaaa aagaaaagaa aagttgctgt ccccgctacc     5340

ccaatcccaa atccaaacag cctctctcat ctcacagtaa gggggaaaaa tcacccaaaa     5400

aagctaagtg atcttttgaa aacccaaact cttagaagtc taagattatt atagtcaact     5460

catgaagtgt catcataaaa gatactctaa tattatttaa gtagaaccac atattggttg     5520

tcttggtatg tctagcccct ggcatacaaa atatttaata acactgatat ggtacctgtg     5580

atgtgaaaat gtactatgag tacagcttta taaatactat atatgtacct atatacagaa     5640

aaaaatacaa caaaatcata aaagcactta tctttgaaag aggagttaca gcaattttat     5700

ttagttcttt attgctttgc tatatattct aaattttttt caatgaatat atatcacttt     5760

taaaaaaatt caatggtctt tcttataaat tatctttggc agcatgcgtt tttatatata     5820

catataaaat gtatgggaaa tttttaaagg atacattaaa ttaaagcaaa atatacaaac     5880

aaaaaatcag aatacaaaaa gataaaaaga ttgggaaggg agggagggag taaggaggaa     5940

gggtgggtgg gtatagagaa atataccaaa taatggtaag aagtggggtc ttgacacttt     6000

ctacactttt tttaaataaa aaaaattttt ttctctctct tttttttttt tagagacgaa     6060

gtctcgctat gttgcccagg ctggtcttga actcctggga tcaagagatc ctcctgcctc     6120

agcctcccaa ggtgcttgga ttacaggtgt gagccaccac gcctggtcac tttctacact     6180

ttaatatata tattttttca ttttcaatgt catttttatt agttaattta taatacccat     6240

tcaccattat attcaaagtc tatttgaaga aataaaccag aaagaatgaa atactctagc     6300

tcacatgcta ttcaatacta aattaccttt caaatcacat tcaagaagct gatgatttaa     6360

gctttggcgg tttccaataa atattggtca aaccataatt aaatctcaat atatcagtta     6420

gtacctattg agcatctcct tttacaacct aagcattgta ttaggtgctt aaatacaagc     6480

agcttgactt ttaatacatt taaaaataca tatttaagac ttaaaatctt atttatggaa     6540

ttcagttata ttttgaggtt tccagtgctg agaaatttga ggtttgtgct gtctttcagt     6600

ccccaaagct cagttctgag ttctcagact ttggtggaac ttcatgtatt gtcaggttgg     6660

cccgtaatac ctgtgggaca acttcagccc ctgtgcacat ggccaggagg ctggttgcaa     6720

acattttcag gtaggtggac caggacatgc ccctggtcat ggccaggtgg aggcatagtg     6780

ctatacagca ggcagaagtc aatattgatt tgtttttaaa gaaacatgta ctactttcat     6840

aagcagaaaa aatttctatt cttgggggaa aagattatgc cagatcctct aggattaaat     6900

gctgatgcat ctgctaaacc ttcacatatc agaacatatt tactatagaa agaatgaaaa     6960

tgggacattt gtgtgtcacc tatgtgaaca ttccaaaaat attttacaac aactaagtat     7020

tttataaatt ttatgaactg aaatttagtt caagttctag gaaaatacaa accttgctag     7080

atattataaa aatgatacaa tatatattca tttcaggctc atcagaatat atctgttatc     7140

acttgacaag aatgaaaatg caccattttg tagtgcttta aaatcaggaa gatccagagt     7200

actaaaaatg acttcttcct tgaagcttac tcaccaactt cctcccagtt actcactgct     7260

tctgccacaa gcataaacta ggacccagcc agaactccct tgaaatatac acttgcaacg     7320

attactgcat ctatcaaaat ggttcagtgc ctggctacag gttctgcaga tcgactaaga     7380

atttgaaaag tcttgtttat ttcaaaggaa gcccatgtga attctgccca gagttcatcc     7440

cagatatgca gtctaagaat acagacagat cagcagagat gtattctaaa acaggaattc     7500

tggcaatata acaaattgat ttccaatcaa aacagattta cataccatac ttatgtcaag     7560

aagttgtttt gttttattgc atcctagatt ttattttttt gatttatggt ttactttaag     7620

cataaaaaat ttgtcaatac aactcttccc aaaaggcata aacaaaaatt cataaaactt     7680

gcatcacttg agatacttca ggtatgaatt cacaactttg ttacaactta ctatatatat     7740

gcacacatat atatatattt gggtatattg ggggggttct aatttaagaa atgcataatt     7800

ggctatagac agacagttgt ctggaatgaa aatcaatact tttgctataa tcgattactg     7860

aaataatttt actttccagt aaaactggca ttataatttt ttttaatttt taaaacttca     7920

taattttttg ccagactgac ccatgtaaac atacaaatta ctaataatta tgcacgtcac     7980

atctgtaata atggccttca tgtaaacatt tttgtggttt acacataaaa tctctaatta     8040

caaagctata ttatctaaaa ttacagtaag caagaaaatt aatccaagct aagacaatac     8100

ttgcaacatc aattcatcat ctgtgacaag gactgcttaa gtctctttgt ggttaaaaag     8160

gaaaaaaaaa aaaaagacat gttggccaga tgcggtggct cacacctgta atcccagcac     8220

tttgggaggc tgaggtgggc ggatcacccc tggcctgccc aacatggtga aaccccgtct     8280

ctactaaaaa cacaaaaatt agctgggcgt ggtggcgggc gcctgtaatt ccagctactc     8340

gggaggctga ggcaggagaa ttgctagaac ccaggaggca gagattgcag tgagctgaga     8400

ttgcaccatt gcactacagt ctgggcaaca aaagtgaaac tccatcttaa aaaaaaaaag     8460

acaatgttcg tgggtccaaa caagacttaa tggaagtgag tctaaaaatg agctatgtgg     8520

gccaggcgta gtggctccca cctgtaatcc cagcactttg ggaggccgaa gcaggcagat     8580

catgaggtca ggagatggag accatcctgg ccaacacggt gaaatcctgt ctctacaaaa     8640

attagctggg cgtggtggtg cctgcctgta atcccagcta ctcagaaggc tcaggcagga     8700

gaatcgcttg aaccagggag tcggtggcta gagtgagccg agatttgcat cactgcactc     8760

ctgcctggtg acagagcaag actccatctc aaaaaaaaca aacaaaaata aaagataaaa     8820

atgagctatg tgaattaaaa gaggtataac aatagataaa ccatatttta tttaattcct     8880

agtaatgagt aatatttcca aacttctgga atgggcagaa attgctagtt ggcatatttt     8940

taccttttat attcagatac attaaaattc tcaaaaaaaa acacctcaaa gcagatgatc     9000

cgccatctcc ttggataatt tgtgttaact caggataaca gaaaaccaaa attatgagtt     9060

actgatgcaa tattcctaaa tgtaaaaata attaaagcta atagtagatt catcttccaa     9120

tttcatatca gtcttacaaa taaactacat atataacttg cttgccttcc cttctgaggg     9180

ataaagctgt tagaagaatt aaaatcagca ttcttgacta ttcaaccaag ggagggataa     9240

attattactc attctaggga catgggctca taactactac atgtgtaagg acatgaattt     9300

acccaatatt acaatttttc cttttattag tgtgtacagt ggaagaatag acatgttcac     9360

tctggacaaa aaaaaaatta tacttatcag ttatcagaag cacaatgctg aagacagtag     9420

ttccataaca atttgaagta tgtgatcgaa ctagtagatt atcttagtag tagtgaatta     9480

ttgtaaatgt tagtaatttg gcagccactg ggcagaaaaa taagaattga ggctcaatat     9540

tgatattaat ggtggtgatt gacacataaa ttttatcaag tctacacaat ataaaattac     9600

agaaaggtag aagagtatac cagtacaact tcaacatatc ttcactacaa gggagtaaaa     9660

tgacatggcc tagttactat ctaatgaact gcagaaaact aaaagaaaac tccaaggcaa     9720

ctcttctctg ctgatctggt tggtcctttt cctacctttt gcaataccca gatacaaaca     9780

atggatagaa aacaaagtag acttgtagta tgcaggtcac agtgctaaat tcacagaaag     9840

aaacccctga actgaactgc tctatttcct ggtggtcaca aagagtaatt ctggtttaca     9900

cctacagatt gatgtcaatc tacaccctgt tgataacagt gtggccaagg acaaaaaaaa     9960

ggtgctccgt tttaccaatt ctgtaaaaaa ttattggcag ggtaagctcg gctagggcag    10020

gattacattt ctaggactac catccccgaa atttagaaga tattatatcc acataaagca    10080

tatctttcac attaatttgc aaaaatctaa aagctttttc ttagctcaag tgtgtccaag    10140

tttaccctgg cagtttaaaa cgatagttac aagcagcatg ggttgtatca gacacatttg    10200

agggccaatt tcatgtaagt gatattgggc aagttacttc aactatctgt gcctccaagg    10260

tcatactagt gtttatttac ctaaagggta cctgttatgt aactttaggg tgtttacatt    10320

agataatgcc tgcaaaatat ttacttcaac gcctaaaaca tagttaagta ttcaataaat    10380

acctactatt gtcactacta acttaaaagt ttagagatta agagcagaat ctggggtgag    10440

acaaacttag gttcaaatcc tagtattgtt gggtaatctt gggcaagtta cttaacctct    10500

ctgatttgtg taatttaaaa aattagttaa tatacataac agggcttaga agagtatcta    10560

gcacatagca ccatttaagc atttgttatt gctaacatgc aaacaattta agggaaagaa    10620

attttttaaa aaggaagagg gatttgcaaa ctaaaaacaa tgagtatctt atgttcaaag    10680

aaaactaaca aacagccagc tctagcaata attaaattca ctatatactg gggcaggcat    10740

cacaccccaa agctaaaagc gtctacctag gccaggcacg gtggctcatg cctgtaatcc    10800

cagcactttg ggaagcagag gcgggcagat cgcttgagct caggagttca agaccagcct    10860

ggacaacatg gcaaaacacc atctctacaa aaaatacaaa tattaggccg ggcgcagtgg    10920

ctcacgcctg taatcccagc actttgggag gccaaggcgg gtggatcacc tgagatcagg    10980

agttcgagag tagcctggcc aacatggtga aacctcgtct ctattaaaaa tacaaaaaat    11040

tagccaggca tggtggcagg cgcctgtaat cccagctact cagggggatg aggtaggaga    11100

atcgcttgaa cccgggaggc agaggttgca ctgagccgag atcatgccac tgtactccag    11160

cccgggcaac aagagcgaaa ctccatctca aaaaataaat aaataaataa ataaaataaa    11220

gtacaaatat tagccaggga tggtggtgcg cacctgtagt cccagctact tgggaggctg    11280

aagtgggaga atcccctgag cctggggaga atcacccgag cccgggaagt cgaggctgca    11340

gtgagcagtg attgtgccac tgcactccat cctaggtgac agagtgagac cctgtctcaa    11400

aaaaaagaaa ttggcagaat taagtaagtt gatgtttaga gatgaaaaat caacattttt    11460

tcctcagcaa ctgaataaaa acaacagcca ctaccatttt tttgagtacc tatttgtagc    11520

ctatttttta actggtatta ctcgagagag agagagctag gttcgagaca gagctccttc    11580

tcttaataac tgtatgacct agggtatgtc tgttagcctc tctgaggctt caaaggttcc    11640

tcatctgtaa aatggtaata atcataccat tgctacaggg ctgttttgaa gactaattag    11700

gactatgtaa gtaaacatga tgatggctat tattactgtt ccccgccagg ggccatgcaa    11760

gggttgctga ttcacataga ctgtcttata atcctctcaa taactccaag aggtagccag    11820

cacctcagat atacataaaa tgacttaagc ccagagaggt gaagtaagtt gcccacagcc    11880

acacaactag taaatagccc aaacaagctg gattcccagt tagactccgt taatagcact    11940

gctctttacc ttaagtcatt acaatgccta atatgaaata gaatcgcttc tttcttaggg    12000

ttcaagtggt taattattta atgtattcat tcaacaaacc atcatcgagg acctcttaca    12060

agccaagtac tgtgctaagt gctagagtta cggcggtgat tcctgccctt aaaaagtttt    12120

agtgggagaa acaacaggta accaggtcat tgccaaaaca acaaaaataa tcataataaa    12180

gcaggctaaa gcatatttaa ctggccgggg ttttgactat tttagcaagc atgatcagaa    12240

cggttgagga gggaggccag cagcttggcc ggttcaacaa acaagaaaaa accagtgagg    12300

gtggagctaa gataccagag gctgattacg gttaagaatg ttcttgaagg taaggaccag    12360

attctcattt tctatatcct ggggcatcgg tcagcatgga atctggattc tagcacatgt    12420

gaatttcggc ttgaaatgac ctaatgcctt ttccctagtt ccttcgtgtg tcaaatacgc    12480

atggttaccg ctaccagagc tgtagtgggg cttcaatgag gccatgagca tctccataaa    12540

gatgaactac agtgtgtgca aaactaaagg caaaacctgg tccccacacg ccctcccagg    12600

tggtcgcttt ccgtgccgag gcccctccag aggtgccccg agaacctcac catcgcaccc    12660

caaacttcca gggaagggcc tctcccgaga aagcccccac gcccccaccc cgcgccatca    12720

ttcccgaatc tgccctcggc ccctccccgc agcacgctcg caggcggcac atgtcaacca    12780

aaacgccatt tccaccttct cttcccacac gcagtcctct tttcccaggg ctcccccgag    12840

gagggaccca ccccaaaccc cgccattccg tcctccctgc cgccctcgcg tgacgtaaag    12900

ccgaacccgg gaaactggcc gcccccgcct gcggggttcc ctgggcccgg ccgctctaga    12960

actagtggat cccaattgaa ggcctggtct aaatgactcc aaaatcacca cttaattcaa    13020

gagactgatt tccctgagtc aggcccctta aagcagctat ttcaatggga cagggaaaca    13080

accctaggat ctggattaga atcacttggg ggctgccaca cccccagggc tctgatcctg    13140

cccttctccc acacgcacat tcacatactg ctgcagtgac cttccatttc taatgggttc    13200

ctgggccatc tgtcaggtat agggaatgga aaaggggttg gggaggctct gcttcagaaa    13260

gtttgtgtca ggggctccca gagcctccac agatagatag caggggtccc caccctacca    13320

tggcagctat aaatgtgatc aacatttatt ggcctaggat acagcagtta gcaaaatgcc    13380

tgatgtagtt cccactccgt ggaggttgca ggctagctct ttcctaatga gctttacagc    13440

agaagctgtt ttatcgttaa gtgccccaca gagacacttt accaggaggc tgggagagtt    13500

ctccagattt gggagaggcg cagagacagt gtgtgagccg agccctgtct cagcaatcca    13560

cctggaggag ctagagtatc ctcctccctt taccattcag accgagagaa aaagcccagc    13620

ttgtgtgcac cctcgtgggg ttaaggcgag ctgttcctgg tttaaagcct ttcagtattt    13680

gttttgatgt aaggctctgt ggtttggggg ggaacatctg taaacattat tagttgattt    13740

ggggtttgtc tttgatggtt tctatctgca attatcgtca tgtatattta agtgtctgtt    13800

atagaaaacc cacacccact gtcctgtaaa cttttctcag tgtccagact ttctgtaatc    13860

acattttaat tgccacctcg tatttcacct ctacatttga aatctggcgt ctgtttcaag    13920

ccagtgtgtt ttttcttcgt tctgtaataa acagccagga gaaaagtgcc tctatgtttt    13980

tatttttcaa gggagtattc agtacctaca aacccaagtc aggaagcctg ctagtggctt    14040

tggttctttc agaggctgct cgatgccttg tgtgtcagaa agaaagattc agcagttttg    14100

catcatggca aagaagcctg ttattttggg gctcagcccc tcattttata gaggatgaaa    14160

cagaggggga tgggaggtca caaagacaac tgccccggga gcaggtgtgg gggagacttg    14220

ccctgagggt ctagacgctc tgcaccaccg tcctgtctcc cttgctgaag accacacatg    14280

cccttctttg accagaccct gccacctgat aggccaggac ctggtaggcg ggtacccagg    14340

tttcatggat ggaaccacat ctccccaaaa gtggggaggt agctactggg atgcacgcct    14400

cccgccatgt gctataggag agcagctgaa gcaacagttg ggatcagatg tagtcacaat    14460

tgaatgcatc atcacattta tccctctaag tggctgggag agttgatatc ctcatcccta    14520

aggtacaaaa tgttccaatt tgatcagtgg ctttcaggag ctgagaaagg catgtgctct    14580

gaggcagagc tgttatgtcc cgcagagcct aaaaatgctc taagaacatg ctccctgcca    14640

aaattctcaa tggctgtgac aagggacaac gatcgaccaa tgggggtgga agcagacctc    14700

cgcagtccag gggccagagc taggacagag gggtcggaga aagagtcatt ttcccaacac    14760

tccagctctt ggccagtcct cacacagtcc cctcctgctt cctgctgaga gagatatcct    14820

cataggtctg ggtaaagtcc ttcagtcagc tttcattccc tgtcaccaac tttgtctctg    14880

ttctccctgc ccgtctcagg cagcactcct caggaaacct ctccaagagc cagcctcact    14940

gcagcgccca ctattgtccc tctgcctcaa gtgtcccatc catgccaggc cccaggcagg    15000

ctgcagcttt ccctcagggc cacaccaaag cacttgggct cagctgtgct gtccccctcc    15060

atcactgagc tcaggggcag caggggtggg gtgccaggag gcccattcac ccttctctgg    15120

ctctgtgttg gacccacctg cccagccact gctgcttaga acctacccgc tgggaaaatg    15180

aagccctccc ggaggggcca cctcaacctg agagcctcac ggatcacagt tgtccccact    15240

cagctctgcc agccctcaga gacccataga taaaagctga gcttggctcg cagagctggt    15300

tccatcttcc attcccagag ggttcaactt cctaccccaa ccacacaggg aacctcaagg    15360

ctgagccagt gtgggctgca gtgcagacca gcttcctgga cacgtcctgc cacctgaccc    15420

caggctggcc tcactgcccc tggcactcct gaccctatcc tcattcctcc tggcagtgcg    15480

tgttctgcca ttccgctttc ccttagctgt cctctcactg tactgtcagc ttctcctttt    15540

ccaggtgccc cccaggggct ttccacatga ccctgtcacc ccacagccca tccagcacca    15600

attccagctc tctgccaccc ttcaaaggag tgacagtgcc ctgcttcacc tcccactcac    15660

ccctcaaccc agagcaatct ggctccagtc ttgcctcctt ccccctaagt actctagtca    15720

cagttccaaa ttcctcctgg tcataaagcc aaatgaagct tcctggtcct cagcggactt    15780

gccacttcag cagtactgga ctctctcctc ccagaaacct gtttcccctt ggctcctgga    15840

gcccacactc tgctggaatc cttctgcctc tctggcctgt agcctggccc tctctcccaa    15900

cctgaggtcc attctctcct gctcctccac aagatgttgc tccttccatt acttcctccc    15960

tctcaaccaa agctccttca ttagctcttt atcttctggt ttcttcccct gggcagacga    16020

atggattcaa gagcctgtgg cccagcagcc cagcactcca ggatctcagc acttcagcat    16080

cccagtaccc tagcatctca ataccccagc accccagcac catagtattc cagcacccca    16140

ttgtccaagc atctcagcac tccagcatcc cagcacccca acactccagc agcccagaat    16200

ctcagcaccc tagcactgca gcatctcagg accccagcac ttcagcatcc cagcacacta    16260

gtactccagc atctcggcac cccagcacct aggcatccca acacccagca ccccagcact    16320

taagcatccc accactacag tatctcaaca ctccagcacc ccagcaccat agtgttccag    16380

caccccagca tcccaacacc ccagcactta agcatcccaa cacctcggca tcccaacacc    16440

ccagcactgc agcatctcag caccttagca tcccagtgcc ctagcatctc aatgctccag    16500

cacaccagta ctacagtatt ccagcacccc agcactccag catctcagca ctgcagcact    16560

gcagcactcc agcatcccaa aatcccagca tcccaacacc ccagcagacc agcagaccag    16620

catctcagca ccgcagcatc caaggactat cccagcatcc cagcaaccca gcacctcagc    16680

atcccaacac cccagcattt cagcatggca acaccccagt accccagcac ttcagcaccc    16740

cagtatccca gcatctcagc gacccagtat cacaaaacct cagcatccta gcaccccagc    16800

accccagcac cttagcacct tagcatccca gcatctcagc gcctcagcat cttgatattc    16860

tggctgaggt cagcgtggtg tatctagtca gggtcctaac tttcacttcg cagggaaatg    16920

ctgctggact gggtctcatg ttgggctgaa gctctctaga ccccttgaag acagcataaa    16980

agagcttgga gacgctgggt gtcccccatg gaagagttca ctctcatcct gctttgacaa    17040

cagccttctc tggggtccct cacgggcccc tctttcttac tgcaagtttg tctctgagaa    17100

gactgtgatg cagaagtcac tcagctgcct gtggctcctg aagagctgaa ggtggaggcc    17160

tgtaggcctc cctatgagag gcgcagaaaa aaccatgatt gctagtgggg aggtgctccc    17220

tctacaaccc actccataat ctgcccccgc ccagctctga ggccagcccc aggggaaaat    17280

gccagatccc cagggaggtg tgtgagacct caggggctcc ctcctccctt acagcaggct    17340

caggcccctg ggggcctcag ggccaaggtc tgtgggtaag ctactatctc tcacttgtcc    17400

tctagccaca aaagccaggg agatctggca atggacatga ggttctgaag aagcacatat    17460

gactggcttc ctaatgcgtg gttgttcagt gattcaataa acacgcatgg gccaggcatg    17520

gggaaataga caaacatgat ccccaacctc tcccagagtg aactgggagg gaggagtgtt    17580

catccctcag gattacacca gagaaacaaa ccagcaggag atatatatgg ttttgggggg    17640

tcaagaaaga ggaaaaacct ggcaaggcaa gtccaaaatc ataggacagg ctgtcaggaa    17700

gggcagcctg gaacctctca agcaggagct gatgctgcag tccacaggca gaatttcttc    17760

ttcctcgggg aaatctcagc tttgttctta aggcctttca actgattggc tgaggtctgc    17820

cccttccccc acattctcca ggataatctt ccttacttaa agtcaactat taatcacagc    17880

tacaaaatcc cttcacagct acacatagat cagtgtttga ttgacgaaca gcccctacag    17940

cctagccaag ttgacacata aaactaacca tcacaggggg acaaatgatg taaacacatc    18000

aacaaataaa acagtaacaa gttaaggtct atggaaaaaa cacagaaggg gcagagagaa    18060

agaaagcaag aaggagagtc ccagtttgct agggcttgtg ggaagtgggg agcagttctc    18120

tttagctagg atatttggga aaggcatatc tgaaggagtg atatttgagc ttagattaaa    18180

agatgggaag gagcaagcca tgcaaagagc taggatgttc caagcagaga cggaacagca    18240

agtgcaaatg tcaggaggaa tagaaggagg ctggtgggtg gggtccagtg agcaagagga    18300

gggcaggcag gagaggggat ggggaggtgg gcaggcccag accacccagg gccctggaga    18360

ctatcctgat ccaacaaggg aagccttgag tcacttcagt gtccatgtgg agaatggacc    18420

tcagactgaa tgagggaggc agtaaggagg gcctctacct ccagggcttc gccctgtgga    18480

ctgcgcatag acatctccaa ctcagaaagt ctgaaccaaa ctttccatag ttcccccaag    18540

tctgggcatc ctcctactca gtgaaaggca gccatcacac ctccctgccc tgctcccgga    18600

tgccccaaat cctcttggtc tccaagtcca gaacctgaga cttgtccttg atgtttgtct    18660

ttccctcacc ctttctgtat tctgggaaga tgggtttttt tcccccagat gaatctgtaa    18720

aacttctgtg atcacaataa aaattctggc agtattattt tctggaacat gacaaagtga    18780

ttcaaaatta tttatctgga agactacaaa acaagaatag ccaggaaatt tctaaaaaga    18840

aagaagaagg aggaggagaa agaaggagga ggaaaaggag gagaagaaga aaagaaaaag    18900

aaccaagaaa gggttctagc tctaccaaat attaaaacat atcatgaagc tatttaaaac    18960

aatatggttg tggatactga aaaagatgtg aataaagtgg aaggaaaata aatagaaatg    19020

cacatgggga ttgagactgt gaaaaaggca gcatctcaca tcagtgaggg atgttcaaca    19080

cctggtgttg ggaaaactgg ctagtcattt aaaccaaaca actgggtcct ctacctcact    19140

cctgacatta agatacattt agatgattca aagagtaaga cagaaaaaat aacacgtgaa    19200

aacactatca gaaaacaacg tgggccaggt gtggtgggtc acgcctgtaa tcccagcact    19260

ttgggaggcc gaggcagaca gatcacctga ggtggggagt tcaagaccag cctgaccaac    19320

atggtgaaat cctgtctcta ctaaaaatac aaaattagct gagcgtggtg gcgcatgcct    19380

gtaatcccag ctactcagga ggccgaggca ggagaatcac ttgaacctgg gaggcagagg    19440

ttgtggtgag ccgagatcac gccattgcac tccagcctgg gcaacaagag tgaaaatcca    19500

tctaaaaaaa aaaaaaaaag ccaaggtgga tatttttata gtatcagggt agatcaagct    19560

tctccaatca tgacatgaaa cccagaaacc ataaaagaaa agaatgataa aattgcccac    19620

gtaaagtaaa aagcttgcac acagaaaaac accatacagg ttacaagatg agcagcaaaa    19680

tcagagaaaa aacattgcaa ttcaggacac acagaggcta ttgttcctaa tatttaaaaa    19740

taaaagtagt ggattgtcta caaaaagatg aagacaagaa tttcagaaaa ccaaatactg    19800

catgttttca cttacaagtg gaagctaaac actgagtaca cgtgtacaca aagaatggaa    19860

ccataggcca ggcaccgtgg ctcacgcctg taatcccagt actttgcgag gccgaagcgg    19920

gcggatcacc tgaggtgagg agttcgagac catcctggcc aacatggtga aacccagtct    19980

ctactaaaaa tacaaaaatt agccgggcgt ggtggtgggt gcctgtaatc ccagctactc    20040

gggaggctgc ggcagtagaa tcgcttgaac cctggaggtg gaccttgcag tgagccgaga    20100

tcgcaccact gcactccagc ctgggcaaca gagtgagact ccatctcaaa aaaaaaaaaa    20160

aggaatagaa caatagacac tggggcctac ttgagggagg agggtgagga tcaaaaacct    20220

gcctatcagg tactatgctt attacctggg tggtgaaata atctgtacac caaaccccag    20280

tgacatgcaa tttaccgatg taacaaacct gcccatgtac ccgctgaacc taaaataaaa    20340

gttggaaaaa aatatagaaa ttttctttgt aatagccaaa aactgcaaac agcccaggtg    20400

tctattagta gaatgcataa acaaactcgg gcatgttcat acaatgtaaa actactcatc    20460

aataaaaagt gatacttctc agcaatgaaa agaaactagc tactgatacc agctacaaca    20520

tggatggatt tcaagtgctt tatgatgaga gcaagaagcc agacacaaaa gtgtctatat    20580

atatatacag tatatatacg tatatataca catatataca gtatatatat acatatacat    20640

gtatatatat actgtatata tactgtatat atatacacag tatatatata catatataca    20700

gtgtatatat actgtgtata tatacatgta tatatactgt gtatatatac atgtatatat    20760

actgtgtata tatacatgta tatatactgt gtatatatac atgtatatat atgtatactg    20820

tatatatact gtatatatat atacacatat atacagtata tatatacagt atatactgta    20880

tatatacagt atatacgtgt atatatacat atatacagta tatatgtaaa tatacatata    20940

tacagtatat atgtaaatat acatatatac atgtatatat atacactata tatatacata    21000

tatagtgtat atatacatat atacatgtat atatttacta tatgattcca tttatataaa    21060

gtgccaaaac agtcaaaaat aatctatgtg gaaaaaatca acaaagggat cccccgggct    21120

gcaggaattc gatggcgcgc cgacgtcgca tgcagttagg gataacaggg taatacgacc    21180

atggcatgtc ctctagactc gagcggccgc aataaaatat ctttattttc attacatctg    21240

tgtgttggtt ttttgtgtga atcgtaacta acatacgctc tccatcaaaa caaaacgaaa    21300

caaaacaaac tagcaaaata ggctgtcccc agtgcaagtg caggtgccag aacatttctc    21360

tatcgaagga tctgcgatcg ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca    21420

gtccccgaga agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc    21480

ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga    21540

gaaccgtata taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc    21600

agaacacagc tgaagcttcg aggggctcgc atctctcctt cacgcgcccg ccgccctacc    21660

tgaggccgcc atccacgccg gttgagtcgc gttctgccgc ctcccgcctg tggtgcctcc    21720

tgaactgcgt ccgccgtcta ggtaagttta aagctcaggt cgagaccggg cctttgtccg    21780

gcgctccctt ggagcctacc tagactcagc cggctctcca cgctttgcct gaccctgctt    21840

gctcaactct acgtctttgt ttcgttttct gttctgcgcc gttacagatc caagctgtga    21900

ccggcgccta cgtaagtgat atctactaga tttatcaaaa agagtgttga cttgtgagcg    21960

ctcacaattg atacttagat tcatcgagag ggacacgtcg actactaacc ttcttctctt    22020

tcctacagct gagatcaccg gcgaaggagg gccaccatgg gtcaccagca gttggtcatc    22080

tcttggtttt ccctggtttt tctggcatct cccctcgtgg ccatatggga actgaagaaa    22140

gatgtttatg tcgtagaatt ggattggtat ccggatgccc ctggagaaat ggtggtcctc    22200

acctgtgaca cccctgaaga agatggtatc acctggacct tggaccagag cagtgaggtc    22260

ttaggctctg gcaaaaccct gaccatccaa gtcaaagagt ttggagatgc tggccagtac    22320

acctgtcaca aaggaggcga ggttctaagc cattcgctcc tgctgcttca caaaaaggaa    22380

gatggaattt ggtccactga tattttaaag gaccagaaag aacccaaaaa taagaccttt    22440

ctaagatgcg aggccaagaa ttattctgga cgtttcacct gctggtggct gacgacaatc    22500

agtactgatt tgacattcag tgtcaaaagc agcagaggct cttctgaccc ccaaggggtg    22560

acgtgcggag ctgctacact ctctgcagag agagtcagag gggacaacaa ggagtatgag    22620

tactcagtgg agtgccagga ggacagtgcc tgcccagctg ctgaggagag tctgcccatt    22680

gaggtcatgg tggatgccgt tcacaagctc aagtatgaaa actacaccag cagcttcttc    22740

atcagggaca tcatcaaacc tgacccaccc aagaacttgc agctgaagcc attaaagaat    22800

tctcggcagg tggaggtcag ctgggagtac cctgacacct ggagtactcc acattcctac    22860

ttctccctga cattctgcgt tcaggtccag ggcaagagca agagagaaaa gaaagataga    22920

gtcttcacgg acaagacctc agccacggtc atctgccgca aaaatgccag cattagcgtg    22980

cgggcccagg accgctacta tagctcatct tggagcgaat gggcatctgt gccctgcagt    23040

gttcctggag taggggtacc tggggtgggc gccagaaacc tccccgtggc cactccagac    23100

ccaggaatgt tcccatgcct tcaccactcc caaaacctgc tgagggccgt cagcaacatg    23160

ctccagaagg ccagacaaac tctagaattt tacccttgca cttctgaaga gattgatcat    23220

gaagatatca caaaagataa aaccagcaca gtggaggcct gtttaccatt ggaattaacc    23280

aagaatgaga gttgcctaaa ttccagagag acctctttca taactaatgg gagttgcctg    23340

gcctccagaa agacctcttt tatgatggcc ctgtgcctta gtagtattta tgaagacttg    23400

aagatgtacc aggtggagtt caagaccatg aatgcaaagc tgctgatgga tcctaagagg    23460

cagatctttc tagatcaaaa catgctggca gttattgatg agctgatgca ggccctgaat    23520

ttcaacagtg agactgtgcc acaaaaatcc tcccttgaag aaccggattt ttataaaact    23580

aaaatcaagc tctgcatact tcttcatgct ttcagaattc gggcagtgac tattgataga    23640

gtgatgagct atctgaatgc ttcctaaaaa gcgaggtccc tccaaaccgt tgtcattttt    23700

ataaaacttt gaaatgagga aactttgata ggatgtggat taagaactag ggaggggcta    23760

gctcgacatg ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa    23820

aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtgaaat ttgtgatgct    23880

attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt    23940

cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc    24000

tacaaatgtg gtagatccat ttattagcta ggagtttcag aaaagggggc ctgagtggcc    24060

ccttttttca acttaattaa cctgcagggc ctgaaataac ctctgaaaga ggaacttggt    24120

taggtacctt ctgaggctga aagaaccagc tgtggaatgt gtgtcagtta gggtgtggaa    24180

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa    24240

ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca    24300

attagtcagc aaccatagtc ccactagttt catcaccacc gccacccccc cgcccccccg    24360

ccatctgaaa gggttctagg ggatttgcaa cctctctcgt gtgtttcttc tttccgagaa    24420

gcgccgccac acgagaaagc tggccgcgaa agtcgtgctg gaatcacttc caacgaaacc    24480

ccaggcatag atgggaaagg gtgaagaaca cgttgtcatg gctaccgttt ccccggtcac    24540

ggaataaacg ctctctagga tccggaagta gttccgccgc gacctctcta aaaggatgga    24600

tgtgttctct gcttacattc attggacgtt ttcccttaga ggccaaggcc gcccaggcaa    24660

aggggcggtc ccacgcgtga ggggcccgcg gagccatttg attggagaaa agctgcaaac    24720

cctgaccaat cggaaggagc cacgcttcgg gcatcggtca ccgcacctgg acagctccga    24780

ttggtggact tccgcccccc ctcacgaatc ctcattgggt gccgtgggtg cgtggtgcgg    24840

cgcgattggt gggttcatgt ttcccgtccc ccgcccgcga gaagtggggg tgaaaagcgg    24900

cccgacctgc ttggggtgta gtgggcggac cgcgcggctg gaggtgtgag gatccgaacc    24960

caggggtggg gggtggaggc ggctcctgcg atcgaagggg acttgagact caccggtcgc    25020

acgtcatgaa tctagaacca tggcttcgta ccccggccat cagcacgcgt ctgcgttcga    25080

ccaggctgcg cgttctcgcg gccatagcaa ccgacgtacg gcgttgcgcc ctcgccggca    25140

gcaagaagcc acggaagtcc gcccggagca gaaaatgccc acgctactgc gggtttatat    25200

agacggtccc cacgggatgg ggaaaaccac caccacgcaa ctgctggtgg ccctgggttc    25260

gcgcgacgat atcgtctacg tacccgagcc gatgacttac tggcgggtgc tgggggcttc    25320

cgagacaatc gcgaacatct acaccacaca acaccgcctt gaccagggtg agatatcggc    25380

cggggacgcg gcggtggtaa tgacaagcgc ccagataaca atgggcatgc cttatgccgt    25440

gaccgacgcc gttctggctc ctcatatcgg gggggaggct gggagctcac atgccccgcc    25500

cccggccctc accctcatct tcgaccgcca tcccatcgcc gccctcctgt gctacccggc    25560

cgcgcgatac cttatgggca gcatgacccc ccaggccgtg ctggcgttcg tggccctcat    25620

cccgccgacc ttgcccggca caaacatcgt gttgggggcc cttccggagg acagacacat    25680

cgaccgcctg gccaaacgcc agcgccccgg cgagcggctt gacctggcta tgctggccgc    25740

gattcgccgc gtttacgggc tgcttgccaa tacggtgcgg tatctgcagg gcggcgggtc    25800

gtggcgggag gattggggac agctttcggg gacggccgtg ccgccccagg gtgccgagcc    25860

ccagagcaac gcgggcccac gaccccatat cggggacacg ttatttaccc tgtttcgggc    25920

ccccgagttg ctggccccca acggcgacct gtacaacgtg tttgcctggg ccttggacgt    25980

cttggccaaa cgcctccgtc ccatgcacgt ctttatcctg gattacgacc aatcgcccgc    26040

cggctgccgg gacgccctgc tgcaacttac ctccgggatg atccagaccc acgtcaccac    26100

cccaggctcc ataccgacga tctgcgacct ggcgcgcacg tttgcccggg agatggggga    26160

ggctaactga gtatacccta ggattatccc taatacctgc caccccactc ttaatcagtg    26220

gtggaagaac ggtctcagaa ctgtttgttt caattggcca tttaagttta gtagtaaaag    26280

actggttaat gataacaatg catcgtaaaa ccttcagaag gaaaggagaa tgttttgtgg    26340

accactttgg ttttcttttt tgcgtgtggc agttttaagt tattagtttt taaaatcagt    26400

actttttaat ggaaacaact tgaccaaaaa tttgtcacag aattttgaga cccattaaaa    26460

aagttaaatg agaaacctgt gtgttccttt ggtcaacacc gagacattta ggtgaaagac    26520

atctaattct ggttttacga atctggaaac ttcttgaaaa tgtaattctt gagttaacac    26580

ttctgggtgg agaatagggt tgttttcccc ccacataatt ggaaggggaa ggaatatcat    26640

ttaaagctat gggagggttt ctttgattac aacactggag agaaatgcag catgttgctg    26700

attgcctgtc actaaaacag gccaaaaact gagtccttgg gttgcataga aagctgcctg    26760

caggcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc    26820

cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac    26880

gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata    26940

tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc    27000

agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta    27060

ttaccatgat gatgcggttt tggcagtaca tcaatgggcg tggatagcgg tttgactcac    27120

ggggatttcc aagtctccac cccattgacg tcaatgggag tttgttttga ctagttaccg    27180

gcggaaacgg tctcgggttg agaggtcacc cgagggacag gcagctgctg aaccaatagg    27240

accggcgcac agggcggatg ctgcccctca ttggcggccg ttgagagtga ccaagagcca    27300

atgagtcagc ccggggggcg tagcagtgac gtaagttgcg gaggaggccg cttcgaatcg    27360

gcagcggcca gcttggtggc atggaccaat cagcgtcctc caacgaggag cgccttcgcc    27420

aatcggaggc ctccacgacg gggctggggg gagggtatat aagccgagtc ggcggcggcg    27480

cgctccacac gggccgagac cacagcgacg ggagcgtctg cctctgcggg gccgagaggt    27540

aagcgccgcg gcctgccctt tccaggccaa ctcggagccc gtctcgtggc tccgcctgat    27600

cgggggctcc tgtcgccctc agatcggtcg gaacgccgtc gcgctccggg actacaagcc    27660

tgttgctggg cccggagact gccgaaggac cgctgagcac tgtcctcagc gccggcacca    27720

tggattggat ctggcggatc ctgttccttg tgggagctgc cacaggcgcc cattctgaag    27780

ttcagctggt tcagtctggc gccgaagtga agaaacctgg cgcctctgtg aaggtgtcct    27840

gcaaagcttc tggcggcacc ttcagcagct acgccatctc ttgggttcga caggcccctg    27900

gacaaggcct ggaatggatg ggcagaatca tccccatcct gggaatcgcc aactacgccc    27960

agaaattcca gggcagagtg accatcaccg ccgacaagag cacaagcacc gcctacatgg    28020

aactgagcag cctgagaagc gaggacaccg ccgtgtacta ctgtgccaga agcggccacg    28080

gctacagcta cggcgccttt gattattggg gccagggcac cctggtcacc gtttctagcg    28140

gaggcggagg tagtggtggc ggaggttcag gcggcggagg atctcaatct gtgctgacac    28200

agcctccaag cgtgtcaggt gctcctggcc agagagtgac aatcagctgt acaggcagca    28260

gcagcaacat cggagccggc tatgacgtgc actggtatca gcagctgcct ggcacagccc    28320

ctaaactgct gatctacggc aacagcaaca gacccagcgg cgtgcccgat agattttccg    28380

gctctaagag cggcacaagc gccagcctgg ctattactgg actgcaggcc gaggacgagg    28440

ccgactacta ctgtcagagc tacgacagca gcctgtccgg cagctacgtt gtgtttggcg    28500

gcggaacaaa gctgaccgtg ctggaagcca agagctgcga caagacccac acctgtcctc    28560

catgtcctgc tccagaactg ctcggcggac cttccgtgtt cctgtttcct ccaaagccta    28620

aggacaccct gatgatcagc agaacccctg aagtgacctg cgtggtggtg gatgtgtccc    28680

acgaggaccc agaagtgaag ttcaattggt acgtggacgg cgtggaagtg cacaacgcca    28740

agaccaagcc tagagaggaa cagtacaaca gcacctacag agtggtgtcc gtgctgacag    28800

tgctgcacca ggattggctg aacggcaaag agtacaagtg caaggtgtcc aacaaggccc    28860

tgcctgctcc tatcgagaaa accatcagca aggccaaggg ccagcctagg gaaccccagg    28920

tttacacact gccacctagc agggacgagc tgaccaagaa tcaggtgtcc ctgacctgcc    28980

tggtcaaggg cttctaccct tccgatatcg ccgtggaatg ggagagcaat ggccagccag    29040

agaacaacta caagacaacc cctcctgtgc tggacagcga cggctcattc ttcctgtact    29100

ccaagctgac tgtggacaag agccggtggc agcagggcaa tgtgttcagc tgtagcgtga    29160

tgcacgaggc cctgcacaac cactacacac agaagtccct gtctctgagc cccggaaaag    29220

gtggcggtgg ctcttaccct tacgacgtgc cagattacgc cggctatccc tacgatgtgc    29280

ctgactatgc tggctacccc tatgacgtcc ccgactacgc ttaactagct acggaattcc    29340

ggctagctgg ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat    29400

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat    29460

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca    29520

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggaaat    29580

gttaattaac tagccatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca    29640

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc    29700

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta    29760

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt    29820

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc    29880

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg    29940

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg    30000

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag    30060

ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc    30120

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat    30180

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg    30240

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc    30300

tggccttttg ctcagggttc gaaatcgata agcttggatc cggagagctc ccaacgcgtc    30360

ggctagctag tagggataac agggtaataa gcgtcgacgg cgcgccccta ggggccggcc    30420

ttaattaaat caagcttatc gataccgtcg aacctcgagg gggggcatca ctccgcccta    30480

aaacctacgt cacccgcccc gttcccacgc cccgcgccac gtcacaaact ccaccccctc    30540

attatcatat tggcttcaat ccaaaataag gtatattatt gatgatgttt               30590


<210>  51
<211>  39752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSTAT


<220>
<221>  misc_feature
<222>  (5915)..(5917)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (32912)..(32912)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34601)..(34601)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (38163)..(38168)
<223>  n is a, c, g, or t

<400>  51
taacatcatc aattatacct tccattttgg attgaagcca atatgataat gagggggtgg       60

agtttgtgac gtggcgcggg gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag      120

tgtgatgttg caagtgtggc ggaacacatg taagcgacgg atgtggcaaa agtgacgttt      180

ttggtgtgcg ccggtgtaca caggaagtga caattttcgc gcggttttag gcggatgttg      240

tagtaaattt gggcgtaacc gagtaagatt tggccatttt cgcgggaaaa ctgaataaga      300

ggaagtgaaa tctgaataat tttgtgttac tcatagcgcg taatatttgt ctagggccgc      360

ggggactttg accgtttacg tggagactcg cccaggtgtt tttctcaggt gttttccgcg      420

tacgtcggcg gctcgtggct cttccgggaa aaggattctc ggaaagtggt tcgagtacgt      480

cggcggctcg tggctcttcc gggaaaagga ttctcggaaa gtggttcgaa gtacgtcgac      540

cacaaacccc gcccagcgtc ttgtcattgg cgtcgacgct gtacggggtc aaagttggcg      600

ttttattatt atagtcagct gacgtgtagt gtatttatac ccggtgagtt cctcaagagg      660

ccactcttga gtgccagcga gtagagtttt ctcctccgag ccgctccgac accgggactg      720

aaaatgagac atattatctg ccacggaggt gttattaccg aagaaatggc cgccagtctt      780

ttggaccagc tgatcgaaga ggtactggct gataatcttc cacctcctag ccattttgaa      840

ccacctaccc ttcacgaact gtatgattta gacgtgacgg cccccgaaga tcccaacgag      900

gaggcggttt cgcagatttt tcccgactct gtaatgttgg cggtgcagga agggattgac      960

ttactcactt ttccgccggc gcccggttct ccggagccgc ctcacctttc ccggcagccc     1020

gagcagccgg agcagagagc cttgggtccg gtttctatgc caaaccttgt accggaggtg     1080

atcgatccac ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt agattatgtg     1140

gagcaccccg ggcacggttg caggtcttgt cattatcacc ggaggaatac gggggaccca     1200

gatattatgt gttcgctttg ctatatgagg acctgtggca tgtttgtcta cagtaagtga     1260

aaattatggg cagtgggtga tagagtggtg ggtttggtgt ggtaattttt tttttaattt     1320

ttacagtttt gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg     1380

aacctgagcc tgagcccgag ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa     1440

tggcgcctgc tatcctgaga cgcccgacat cacctgtgtc tagagaatgc aatagtagta     1500

cggatagctg tgactccggt ccttctaaca cacctcctga gatacacccg gtggtcccgc     1560

tgtgccccat taaaccagtt gccgtgagag ttggtgggcg tcgccaggct gtggaatgta     1620

tcgaggactt gcttaacgag cctgggcaac ctttggactt gagctgtaaa cgccccaggc     1680

cataaggtgt aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg     1740

atgtaagttt aataaagggt gagataatgt ttaacttgca tggcgtgtta aatggggcgg     1800

ggcttaaagg gtatataatg cgccgtgggc taatcttggt tacatctgac ctcatggagg     1860

cttgggagtg tttggaagat ttttctgctg tgcgtaactt gctggaacag agctctaaca     1920

gtacctcttg gttttggagg tttctgtggg gctcatccca ggcaaagtta gtctgcagaa     1980

ttaaggagga ttacaagtgg gaatttgaag agcttttgaa atcctgtggt gagctgtttg     2040

attctttgaa tctgggtcac caggcgcttt tccaagagaa ggtcatcaag actttggatt     2100

tttccacacc ggggcgcgct gcggctgctg ttgctttttt gagttttata aaggataaat     2160

ggagcgaaga aacccatctg agcggggggt acctgctgga ttttctggcc atgcatctgt     2220

ggagagcggt tgtgagacac aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga     2280

taataccgac ggaggagcag cagcagcagc aggaggaagc caggcggcgg cggcaggagc     2340

agagcccatg gaacccgaga gccggcctgg accctcggga atgaatgttg tacaggtggc     2400

tgaactgtat ccagaactga gacgcatttt gacaattaca gaggatgggc aggggctaaa     2460

gggggtaaag agggagcggg gggcttgtga ggctacagag gaggctagga atctagcttt     2520

tagcttaatg accagacacc gtcctgagtg tattactttt caacagatca aggataattg     2580

cgctaatgag cttgatctgc tggcgcagaa gtattccata gagcagctga ccacttactg     2640

gctgcagcca ggggatgatt ttgaggaggc tattagggta tatgcaaagg tggcacttag     2700

gccagattgc aagtacaaga tcagcaaact tgtaaatatc aggaattgtt gctacatttc     2760

tgggaacggg gccgaggtgg agatagatac ggaggatagg gtggccttta gatgtagcat     2820

gataaatatg tggccggggg tgcttggcat ggacggggtg gttattatga atgtaaggtt     2880

tactggcccc aattttagcg gtacggtttt cctggccaat accaacctta tcctacacgg     2940

tgtaagcttc tatgggttta acaatacctg tgtggaagcc tggaccgatg taagggttcg     3000

gggctgtgcc ttttactgct gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc     3060

aattaagaaa tgcctctttg aaaggtgtac cttgggtatc ctgtctgagg gtaactccag     3120

ggtgcgccac aatgtggcct ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt     3180

gattaagcat aacatggtat gtggcaactg cgaggacagg gcctctcaga tgctgacctg     3240

ctcggacggc aactgtcacc tgctgaagac cattcacgta gccagccact ctcgcaaggc     3300

ctggccagtg tttgagcata acatactgac ccgctgttcc ttgcatttgg gtaacaggag     3360

gggggtgttc ctaccttacc aatgcaattt gagtcacact aagatattgc ttgagcccga     3420

gagcatgtcc aaggtgaacc tgaacggggt gtttgacatg accatgaaga tctggaaggt     3480

gctgaggtac gatgagaccc gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat     3540

taggaaccag cctgtgatgc tggatgtgac cgaggagctg aggcccgatc acttggtgct     3600

ggcctgcacc cgcgctgagt ttggctctag cgatgaagat acagattgag gtactgaaat     3660

gtgtgggcgt ggcttaaggg tgggaaagaa tatataaggt gggggtctta tgtagttttg     3720

tatctgtttt gcagcagccg ccgccgccat gagcaccaac tcgtttgatg gaagcattgt     3780

gagctcatat ttgacaacgc gcatgccccc atgggccggg gtgcgtcaga atgtgatggg     3840

ctccagcatt gatggtcgcc ccgtcctgcc cgcaaactct actaccttga cctacgagac     3900

cgtgtctgga acgccgttgg agactgcagc ctccgccgcc gcttcagccg ctgcagccac     3960

cgcccgcggg attgtgactg actttgcttt cctgagcccg cttgcaagca gtgcagcttc     4020

ccgttcatcc gcccgcgatg acaagttgac ggctcttttg gcacaattgg attctttgac     4080

ccgggaactt aatgtcgttt ctcagcagct gttggatctg cgccagcagg tttctgccct     4140

gaaggcttcc tcccctccca atgcggttta aaacataaat aaaaaaccag actctgtttg     4200

gatttggatc aagcaagtgt cttgctgtct ttatttaggg gttttgcgcg cgcggtaggc     4260

ccgggaccag cggtctcggt cgttgagggt cctgtgtatt ttttccagga cgtggtaaag     4320

gtgactctgg atgttcagat acatgggcat aagcccgtct ctggggtgga ggtagcacca     4380

ctgcagagct tcatgctgcg gggtggtgtt gtagatgatc cagtcgtagc aggagcgctg     4440

ggcgtggtgc ctaaaaatgt ctttcagtag caagctgatt gccaggggca ggcccttggt     4500

gtaagtgttt acaaagcggt taagctggga tgggtgcata cgtggggata tgagatgcat     4560

cttggactgt atttttaggt tggctatgtt cccagccata tccctccggg gattcatgtt     4620

gtgcagaacc accagcacag tgtatccggt gcacttggga aatttgtcat gtagcttaga     4680

aggaaatgcg tggaagaact tggagacgcc cttgtgacct ccaagatttt ccatgcattc     4740

gtccataatg atggcaatgg gcccacgggc ggcggcctgg gcgaagatat ttctgggatc     4800

actaacgtca tagttgtgtt ccaggatgag atcgtcatag gccattttta caaagcgcgg     4860

gcggagggtg ccagactgcg gtataatggt tccatccggc ccaggggcgt agttaccctc     4920

acagatttgc atttcccacg ctttgagttc agatgggggg atcatgtcta cctgcggggc     4980

gatgaagaaa acggtttccg gggtagggga gatcagctgg gaagaaagca ggttcctgag     5040

cagctgcgac ttaccgcagc cggtgggccc gtaaatcaca cctattaccg ggtgcaactg     5100

gtagttaaga gagctgcagc tgccgtcatc cctgagcagg ggggccactt cgttaagcat     5160

gtccctgact cgcatgtttt ccctgaccaa atccgccaga aggcgctcgc cgcccagcga     5220

tagcagttct tgcaaggaag caaagttttt caacggtttg agaccgtccg ccgtaggcat     5280

gcttttgagc gtttgaccaa gcagttccag gcggtcccac agctcggtca cctgctctac     5340

ggcatctcga tccagcatat ctcctcgttt cgcgggttgg ggcggctttc gctgtacggc     5400

agtagtcggt gctcgtccag acgggccagg gtcatgtctt tccacgggcg cagggtcctc     5460

gtcagcgtag tctgggtcac ggtgaagggg tgcgctccgg gctgcgcgct ggccagggtg     5520

cgcttgaggc tggtcctgct ggtgctgaag cgctgccggt cttcgccctg cgcgtcggcc     5580

aggtagcatt tgaccatggt gtcatagtcc agcccctccg cggcgtggcc cttggcgcgc     5640

agcttgccct tggaggaggc gccgcacgag gggcagtgca gacttttgag ggcgtagagc     5700

ttgggcgcga gaaataccga ttccggggag taggcatccg cgccgcaggc cccgcagacg     5760

gtctcgcatt ccacgagcca ggtgagctct ggccgttcgg ggtcaaaaac caggtttccc     5820

ccatgctttt tgatgcgttt cttacctctg gtttccatga gccggtgtcc acgctcggtg     5880

acgaaaaggc tgtccgtgtc cccgtataca gactnnngtt ttgagaggcc tgtcctcgag     5940

cggtgttccg cggtcctcct cgtatagaaa ctcggaccac tctgagacaa aggctcgcgt     6000

ccaggccagc acgaaggagg ctaagtggga ggggtagcgg tcgttgtcca ctagggggtc     6060

cactcgctcc agggtgtgaa gacacatgtc gccctcttcg gcatcaagga aggtgattgg     6120

tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg gggctataaa agggggtggg     6180

ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg agggccagct gttggggtga     6240

gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga ttgtcagttt ccaaaaacga     6300

ggaggatttg atattcacct ggcccgcggt gatgcctttg agggtggccg catccatctg     6360

gtcagaaaag acaatctttt tgttgtcaag cttggtggca aacgacccgt agagggcgtt     6420

ggacagcaac ttggcgatgg agcgcagggt ttggtttttg tcgcgatcgg cgcgctcctt     6480

ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac cgccattcgg gaaagacggt     6540

ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg ttgtgcaggg tgacaaggtc     6600

aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc cagcagaggc ggccgccctt     6660

gcgcgagcag aatggcggta gggggtctag ctgcgtctcg tccggggggt ctgcgtccac     6720

ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct atcttgcatc cttgcaagtc     6780

tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg tatgggttga gtgggggacc     6840

ccatggcatg gggtgggtga gcgcggaggc gtacatgccg caaatgtcgt aaacgtagag     6900

gggctctctg agtattccaa gatatgtagg gtagcatctt ccaccgcgga tgctggcgcg     6960

cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg ggaccgaggt tgctacgggc     7020

gggctgctct gctcggaaga ctatctgcct gaagatggca tgtgagttgg atgatatggt     7080

tggacgctgg aagacgttga agctggcgtc tgtgagacct accgcgtcac gcacgaagga     7140

ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg acctgcacgt ctagggcgca     7200

gtagtccagg gtttccttga tgatgtcata cttatcctgt cccttttttt tccacagctc     7260

gcggttgagg acaaactctt cgcggtcttt ccagtactct tggatcggaa acccgtcggc     7320

ctccgaacgg taagagccta gcatgtagaa ctggttgacg gcctggtagg cgcagcatcc     7380

cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg agcgaggtgt gggtgagcgc     7440

aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg aagtcagtgt cgtcgcatcc     7500

gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa cgcggatttg gcagggcgaa     7560

ggtgacatcg ttgaagagta tctttcccgc gcgaggcata aagttgcgtg tgatgcggaa     7620

gggtcccggc acctcggaac ggttgttaat tacctgggcg gcgagcacga tctcgtcaaa     7680

gccgttgatg ttgtggccca caatgtaaag ttccaagaag cgcgggatgc ccttgatgga     7740

aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg gagctgagcc cgtgctctga     7800

aagggcccag tctgcaagat gagggttgga agcgacgaat gagctccaca ggtcacgggc     7860

cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg cgacctatgg ccattttttc     7920

tggggtgatg cagtagaagg taagcgggtc ttgttcccag cggtcccatc caaggttcgc     7980

ggctaggtct cgcgcggcag tcactagagg ctcatctccg ccgaacttca tgaccagcat     8040

gaagggcacg agctgcttcc caaaggcccc catccaagta taggtctcta catcgtaggt     8100

gacaaagaga cgctcggtgc gaggatgcga gccgatcggg aagaactgga tctcccgcca     8160

ccaattggag gagtggctat tgatgtggtg aaagtagaag tccctgcgac gggccgaaca     8220

ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag cggtgcacgg gctgtacatc     8280

ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag agtgggaatt tgagcccctc     8340

gcctggcggg tttggctggt ggtcttctac ttcggctgct tgtccttgac cgtctggctg     8400

ctcgagggga gttacggtgg atcggaccac cacgccgcgc gagcccaaag tccagatgtc     8460

cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga tgggagctgt ccatggtctg     8520

gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg tttacctcgc atagacgggt     8580

cagggcgcgg gctagatcca ggtgatacct aatttccagg ggctggttgg tggcggcgtc     8640

gatggcttgc aagaggccgc atccccgcgg cgcgactacg gtaccgcgcg gcgggcggtg     8700

ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt gacgcgggcg agcccccgga     8760

ggtagggggg gctccggacc cgccgggaga gggggcaggg gcacgtcggc gccgcgcgcg     8820

ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg cgacgacgcg gcggttgatc     8880

tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg tgagcttgag cctgaaagag     8940

agttcgacag aatcaatttc ggtgtcgttg acggcggcct ggcgcaaaat ctcctgcacg     9000

tctcctgagt tgtcttgata ggcgatctcg gccatgaact gctcgatctc ttcctcctgg     9060

agatctccgc gtccggctcg ctccacggtg gcggcgaggt cgttggaaat gcgggccatg     9120

agctgcgaga aggcgttgag gcctccctcg ttccagacgc ggctgtagac cacgccccct     9180

tcggcatcgc gggcgcgcat gaccacctgc gcgagattga gctccacgtg ccgggcgaag     9240

acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg tggtggcggt gtgttctgcc     9300

acgaagaagt acataaccca gcgtcgcaac gtggattcgt tgatatcccc caaggcctca     9360

aggcgctcca tggcctcgta gaagtccacg gcgaagttga aaaactggga gttgcgcgcc     9420

gacacggtta actcctcctc cagaagacgg atgagctcgg cgacagtgtc gcgcacctcg     9480

cgctcaaagg ctacaggggc ctcttcttct tcttcaatct cctcttccat aagggcctcc     9540

ccttcttctt cttctggcgg cggtggggga ggggggacac ggcggcgacg acggcgcacc     9600

gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc gacggcgcat ggtctcggtg     9660

acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc cgcccgtcat gtcccggtta     9720

tgggttggcg gggggctgcc atgcggcagg gatacggcgc taacgatgca tctcaacaat     9780

tgttgtgtag gtactccgcc gccgagggac ctgagcgagt ccgcatcgac cggatcggaa     9840

aacctctcga gaaaggcgtc taaccagtca cagtcgcaag gtaggctgag caccgtggcg     9900

ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg tgctgctgat gatgtaatta     9960

aagtaggcgg tcttgagacg gcggatggtc gacagaagca ccatgtcctt gggtccggcc    10020

tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt tttgacatcg gcgcaggtct    10080

ttgtagtagt cttgcatgag cctttctacc ggcacttctt cttctccttc ctcttgtcct    10140

gcatctcttg catctatcgc tgcggcggcg gcggagtttg gccgtaggtg gcgccctctt    10200

cctcccatgc gtgtgacccc gaagcccctc atcggctgaa gcagggctag gtcggcgaca    10260

acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg tagactggaa gtcatccatg    10320

tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag tgcagttggc cataacggac    10380

cagttaacgg tctggtgacc cggctgcgag agctcggtgt acctgagacg cgagtaagcc    10440

ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt actggtatcc caccaaaaag    10500

tgcggcggcg gctggcggta gaggggccag cgtagggtgg ccggggctcc gggggcgaga    10560

tcttccaaca taaggcgatg atatccgtag atgtacctgg acatccaggt gatgccggcg    10620

gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc agatgttgcg cagcggcaaa    10680

aagtgctcca tggtcgggac gctctggccg gtcaggcgcg cgcaatcgtt gacgctctac    10740

cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa    10800

gggtatcatg gcggacgacc ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat    10860

gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc    10920

ttttggcttc cttccaggcg cggcggctgc tgcgctagct tttttggcca ctggccgcgc    10980

gcagcgtaag cggttaggct ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg    11040

agggttattt tccaagggtt gagtcgcggg acccccggtt cgagtctcgg accggccgga    11100

ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc ccgcttgcaa attcctccgg    11160

aaacagggac gagccccttt tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg    11220

cccccctcct cagcagcggc aagagcaaga gcagcggcag acatgcaggg caccctcccc    11280

tcctcctacc gcgtcaggag gggcgacatc cgcggttgac gcggcagcag atggtgatta    11340

cgaacccccg cggcgccggg cccggcacta cctggacttg gaggagggcg agggcctggc    11400

gcggctagga gcgccctctc ctgagcggta cccaagggtg cagctgaagc gtgatacgcg    11460

tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc gagggagagg agcccgagga    11520

gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg catggcctga atcgcgagcg    11580

gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc    11640

acacgtggcg gccgccgacc tggtaaccgc atacgagcag acggtgaacc aggagattaa    11700

ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat    11760

aggactgatg catctgtggg actttgtaag cgcgctggag caaaacccaa atagcaagcc    11820

gctcatggcg cagctgttcc ttatagtgca gcacagcagg gacaacgagg cattcaggga    11880

tgcgctgcta aacatagtag agcccgaggg ccgctggctg ctcgatttga taaacatcct    11940

gcagagcata gtggtgcagg agcgcagctt gagcctggct gacaaggtgg ccgccatcaa    12000

ctattccatg cttagcctgg gcaagtttta cgcccgcaag atataccata ccccttacgt    12060

tcccatagac aaggaggtaa agatcgaggg gttctacatg cgcatggcgc tgaaggtgct    12120

taccttgagc gacgacctgg gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt    12180

gagccggcgg cgcgagctca gcgaccgcga gctgatgcac agcctgcaaa gggccctggc    12240

tggcacgggc agcggcgata gagaggccga gtcctacttt gacgcgggcg ctgacctgcg    12300

ctgggcccca agccgacgcg ccctggaggc agctggggcc ggacctgggc tggcggtggc    12360

acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat gacgaggacg atgagtacga    12420

gccagaggac ggcgagtact aagcggtgat gtttctgatc agatgatgca agacgcaacg    12480

gacccggcgg tgcgggcggc gctgcagagc cagccgtccg gccttaactc cacggacgac    12540

tggcgccagg tcatggaccg catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg    12600

cagcagccgc aggccaaccg gctctccgca attctggaag cggtggtccc ggcgcgcgca    12660

aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc    12720

cggcccgacg aggccggcct ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac    12780

agcggcaacg tgcagaccaa cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg    12840

cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca tggttgcact aaacgccttc    12900

ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc    12960

gcactgcggc taatggtgac tgagacaccg caaagtgagg tgtaccagtc tgggccagac    13020

tattttttcc agaccagtag acaaggcctg cagaccgtaa acctgagcca ggctttcaaa    13080

aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc    13140

ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag cgcccttcac ggacagtggc    13200

agcgtgtccc gggacacata cctaggtcac ttgctgacac tgtaccgcga ggccataggt    13260

caggcgcatg tggacgagca tactttccag gagattacaa gtgtcagccg cgcgctgggg    13320

caggaggaca cgggcagcct ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag    13380

aagatcccct cgttgcacag tttaaacagc gaggaggagc gcattttgcg ctacgtgcag    13440

cagagcgtga gccttaacct gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg    13500

accgcgcgca acatggaacc gggcatgtat gcctcaaacc ggccgtttat caaccgccta    13560

atggactact tgcatcgcgc ggccgccgtg aaccccgagt atttcaccaa tgccatcttg    13620

aacccgcact ggctaccgcc ccctggtttc tacaccgggg gattcgaggt gcccgagggt    13680

aacgatggat tcctctggga cgacatagac gacagcgtgt tttccccgca accgcagacc    13740

ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc    13800

aggccaagca gcttgtccga tctaggcgct gcggccccgc ggtcagatgc tagtagccca    13860

tttccaagct tgatagggtc tcttaccagc actcgcacca cccgcccgcg cctgctgggc    13920

gaggaggagt acctaaacaa ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg    13980

gcatttccca acaacgggat agagagccta gtggacaaga tgagtagatg gaagacgtac    14040

gcgcaggagc acagggacgt gccaggcccg cgcccgccca cccgtcgtca aaggcacgac    14100

cgtcagcggg gtctggtgtg ggaggacgat gactcggcag acgacagcag cgtcctggat    14160

ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca ggctggggag aatgttttaa    14220

aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg ccatggcacc gagcgttggt    14280

tttcttgtat tccccttagt atgcggcgcg cggcgatgta tgaggaaggt cctcctccct    14340

cctacgagag tgtggtgagc gcggcgccag tggcggcggc gctgggttct cccttcgatg    14400

ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg gcctaccggg gggagaaaca    14460

gcatccgtta ctctgagttg gcacccctat tcgacaccac ccgtgtgtac ctggtggaca    14520

acaagtcaac ggatgtggca tccctgaact accagaacga ccacagcaac tttctgacca    14580

cggtcattca aaacaatgac tacagcccgg gggaggcaag cacacagacc atcaatcttg    14640

acgaccggtc gcactggggc ggcgacctga aaaccatcct gcataccaac atgccaaatg    14700

tgaacgagtt catgtttacc aataagttta aggcgcgggt gatggtgtcg cgcttgccta    14760

ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga gttcacgctg cccgagggca    14820

actactccga gaccatgacc atagacctta tgaacaacgc gatcgtggag cactacttga    14880

aagtgggcag acagaacggg gttctggaaa gcgacatcgg ggtaaagttt gacacccgca    14940

acttcagact ggggtttgac cccgtcactg gtcttgtcat gcctggggta tatacaaacg    15000

aagccttcca tccagacatc attttgctgc caggatgcgg ggtggacttc acccacagcc    15060

gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt ccaggagggc tttaggatca    15120

cctacgatga tctggagggt ggtaacattc ccgcactgtt ggatgtggac gcctaccagg    15180

cgagcttgaa agatgacacc gaacagggcg ggggtggcgc aggcggcagc aacagcagtg    15240

gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc aatgcagccg gtggaggaca    15300

tgaacgatca tgccattcgc ggcgacacct ttgccacacg ggctgaggag aagcgcgctg    15360

aggccgaagc agcggccgaa gctgccgccc ccgctgcgca acccgaggtc gagaagcctc    15420

agaagaaacc ggtgatcaaa cccctgacag aggacagcaa gaaacgcagt tacaacctaa    15480

taagcaatga cagcaccttc acccagtacc gcagctggta ccttgcatac aactacggcg    15540

accctcagac cggaatccgc tcatggaccc tgctttgcac tcctgacgta acctgcggct    15600

cggagcaggt ctactggtcg ttgccagaca tgatgcaaga ccccgtgacc ttccgctcca    15660

cgcgccagat cagcaacttt ccggtggtgg gcgccgagct gttgcccgtg cactccaaga    15720

gcttctacaa cgaccaggcc gtctactccc aactcatccg ccagtttacc tctctgaccc    15780

acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg cccgccagcc cccaccatca    15840

ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg gacgctaccg ctgcgcaaca    15900

gcatcggagg agtccagcga gtgaccatta ctgacgccag acgccgcacc tgcccctacg    15960

tttacaaggc cctgggcata gtctcgccgc gcgtcctatc gagccgcact ttttgagcaa    16020

gcatgtccat ccttatatcg cccagcaata acacaggctg gggcctgcgc ttcccaagca    16080

agatgtttgg cggggccaag aagcgctccg accaacaccc agtgcgcgtg cgcgggcact    16140

accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg gcgcaccacc gtcgatgacg    16200

ccatcgacgc ggtggtggag gaggcgcgca actacacgcc cacgccgcca ccagtgtcca    16260

cagtggacgc ggccattcag accgtggtgc gcggagcccg gcgctatgct aaaatgaaga    16320

gacggcggag gcgcgtagca cgtcgccacc gccgccgacc cggcactgcc gcccaacgcg    16380

cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg acgggcggcc atgcgggccg    16440

ctcgaaggct ggccgcgggt attgtcactg tgccccccag gtccaggcga cgagcggccg    16500

ccgcagcagc cgcggccatt agtgctatga ctcagggtcg caggggcaac gtgtattggg    16560

tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac ccgccccccg cgcaactaga    16620

ttgcaagaaa aaactactta gactcgtact gttgtatgta tccagcggcg gcggcgcgca    16680

acgaagctat gtccaagcgc aaaatcaaag aagagatgct ccaggtcatc gcgccggaga    16740

tctatggccc cccgaagaag gaagagcagg attacaagcc ccgaaagcta aagcgggtca    16800

aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga ggtggaactg ctgcacgcta    16860

ccgcgcccag gcgacgggta cagtggaaag gtcgacgcgt aaaacgtgtt ttgcgacccg    16920

gcaccaccgt agtctttacg cccggtgagc gctccacccg cacctacaag cgcgtgtatg    16980

atgaggtgta cggcgacgag gacctgcttg agcaggccaa cgagcgcctc ggggagtttg    17040

cctacggaaa gcggcataag gacatgctgg cgttgccgct ggacgagggc aacccaacac    17100

ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc gcttgcaccg tccgaagaaa    17160

agcgcggcct aaagcgcgag tctggtgact tggcacccac cgtgcagctg atggtaccca    17220

agcgccagcg actggaagat gtcttggaaa aaatgaccgt ggaacctggg ctggagcccg    17280

aggtccgcgt gcggccaatc aagcaggtgg cgccgggact gggcgtgcag accgtggacg    17340

ttcagatacc cactaccagt agcaccagta ttgccaccgc cacagagggc atggagacac    17400

aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt gcaggcggtc gctgcggccg    17460

cgtccaagac ctctacggag gtgcaaacgg acccgtggat gtttcgcgtt tcagcccccc    17520

ggcgcccgcg cggttcgagg aagtacggcg ccgccagcgc gctactgccc gaatatgccc    17580

tacatccttc cattgcgcct acccccggct atcgtggcta cacctaccgc cccagaagac    17640

gagcaactac ccgacgccga accaccactg gaacccgccg ccgccgtcgc cgtcgccagc    17700

ccgtgctggc cccgatttcc gtgcgcaggg tggctcgcga aggaggcagg accctggtgc    17760

tgccaacagc gcgctaccac cccagcatcg tttaaaagcc ggtctttgtg gttcttgcag    17820

atatggccct cacctgccgc ctccgtttcc cggtgccggg attccgagga agaatgcacc    17880

gtaggagggg catggccggc cacggcctga cgggcggcat gcgtcgtgcg caccaccggc    17940

ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct gcccctcctt attccactga    18000

tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt ggccttgcag gcgcagagac    18060

actgattaaa aacaagttgc atgtggaaaa atcaaaataa aaagtctgga ctctcacgct    18120

cgcttggtcc tgtaactatt ttgtagaatg gaagacatca actttgcgtc tctggccccg    18180

cgacacggct cgcgcccgtt catgggaaac tggcaagata tcggcaccag caatatgagc    18240

ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta aaaatttcgg ttccaccgtt    18300

aagaactatg gcagcaaggc ctggaacagc agcacaggcc agatgctgag ggataagttg    18360

aaagagcaaa atttccaaca aaaggtggta gatggcctgg cctctggcat tagcggggtg    18420

gtggacctgg ccaaccaggc agtgcaaaat aagattaaca gtaagcttga tccccgccct    18480

cccgtagagg agcctccacc ggccgtggag acagtgtctc cagaggggcg tggcgaaaag    18540

cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa tagacgagcc tccctcgtac    18600

gaggaggcac taaagcaagg cctgcccacc acccgtccca tcgcgcccat ggctaccgga    18660

gtgctgggcc agcacacacc cgtaacgctg gacctgcctc cccccgccga cacccagcag    18720

aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc gtcctagccg cgcgtccctg    18780

cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag ccagtggcaa ctggcaaagc    18840

acactgaaca gcatcgtggg tctgggggtg caatccctga agcgccgacg atgcttctga    18900

atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg tcgccgccag aggagctgct    18960

gagccgccgc gcgcccgctt tccaagatgg ctaccccttc gatgatgccg cagtggtctt    19020

acatgcacat ctcgggccag gacgcctcgg agtacctgag ccccgggctg gtgcagtttg    19080

cccgcgccac cgagacgtac ttcagcctga ataacaagtt tagaaacccc acggtggcgc    19140

ctacgcacga cgtgaccaca gaccggtccc agcgtttgac gctgcggttc atccctgtgg    19200

accgtgagga tactgcgtac tcgtacaagg cgcggttcac cctagctgtg ggtgataacc    19260

gtgtgctgga catggcttcc acgtactttg acatccgcgg cgtgctggac aggggcccta    19320

cttttaagcc ctactctggc actgcctaca acgccctggc tcccaagggt gccccaaatc    19380

cttgcgaatg ggatgaagct gctactgctc ttgaaataaa cctagaagaa gaggacgatg    19440

acaacgaaga cgaagtagac gagcaagctg agcagcaaaa aactcacgta tttgggcagg    19500

cgccttattc tggtataaat attacaaagg agggtattca aataggtgtc gaaggtcaaa    19560

cacctaaata tgccgataaa acatttcaac ctgaacctca aataggagaa tctcagtggt    19620

acgaaactga aattaatcat gcagctggga gagtccttaa aaagactacc ccaatgaaac    19680

catgttacgg ttcatatgca aaacccacaa atgaaaatgg agggcaaggc attcttgtaa    19740

agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca atttttctca actactgagg    19800

cgaccgcagg caatggtgat aacttgactc ctaaagtggt attgtacagt gaagatgtag    19860

atatagaaac cccagacact catatttctt acatgcccac tattaaggaa ggtaactcac    19920

gagaactaat gggccaacaa tctatgccca acaggcctaa ttacattgct tttagggaca    19980

attttattgg tctaatgtat tacaacagca cgggtaatat gggtgttctg gcgggccaag    20040

catcgcagtt gaatgctgtt gtagatttgc aagacagaaa cacagagctt tcataccagc    20100

ttttgcttga ttccattggt gatagaacca ggtacttttc tatgtggaat caggctgttg    20160

acagctatga tccagatgtt agaattattg aaaatcatgg aactgaagat gaacttccaa    20220

attactgctt tccactggga ggtgtgatta atacagagac tcttaccaag gtaaaaccta    20280

aaacaggtca ggaaaatgga tgggaaaaag atgctacaga attttcagat aaaaatgaaa    20340

taagagttgg aaataatttt gccatggaaa tcaatctaaa tgccaacctg tggagaaatt    20400

tcctgtactc caacatagcg ctgtatttgc ccgacaagct aaagtacagt ccttccaacg    20460

taaaaatttc tgataaccca aacacctacg actacatgaa caagcgagtg gtggctcccg    20520

ggttagtgga ctgctacatt aaccttggag cacgctggtc ccttgactat atggacaacg    20580

tcaacccatt taaccaccac cgcaatgctg gcctgcgcta ccgctcaatg ttgctgggca    20640

atggtcgcta tgtgcccttc cacatccagg tgcctcagaa gttctttgcc attaaaaacc    20700

tccttctcct gccgggctca tacacctacg agtggaactt caggaaggat gttaacatgg    20760

ttctgcagag ctccctagga aatgacctaa gggttgacgg agccagcatt aagtttgata    20820

gcatttgcct ttacgccacc ttcttcccca tggcccacaa caccgcctcc acgcttgagg    20880

ccatgcttag aaacgacacc aacgaccagt cctttaacga ctatctctcc gccgccaaca    20940

tgctctaccc tatacccgcc aacgctacca acgtgcccat atccatcccc tcccgcaact    21000

gggcggcttt ccgcggctgg gccttcacgc gccttaagac taaggaaacc ccatcactgg    21060

gctcgggcta cgacccttat tacacctact ctggctctat accctaccta gatggaacct    21120

tttacctcaa ccacaccttt aagaaggtgg ccattacctt tgactcttct gtcagctggc    21180

ctggcaatga ccgcctgctt acccccaacg agtttgaaat taagcgctca gttgacgggg    21240

agggttacaa cgttgcccag tgtaacatga ccaaagactg gttcctggta caaatgctag    21300

ctaactacaa cattggctac cagggcttct atatcccaga gagctacaag gaccgcatgt    21360

actccttctt tagaaacttc cagcccatga gccgtcaggt ggtggatgat actaaataca    21420

aggactacca acaggtgggc atcctacacc aacacaacaa ctctggattt gttggctacc    21480

ttgcccccac catgcgcgaa ggacaggcct accctgctaa cttcccctat ccgcttatag    21540

gcaagaccgc agttgacagc attacccaga aaaagtttct ttgcgatcgc accctttggc    21600

gcatcccatt ctccagtaac tttatgtcca tgggcgcact cacagacctg ggccaaaacc    21660

ttctctacgc caactccgcc cacgcgctag acatgacttt tgaggtggat cccatggacg    21720

agcccaccct tctttatgtt ttgtttgaag tctttgacgt ggtccgtgtg caccggccgc    21780

accgcggcgt catcgaaacc gtgtacctgc gcacgccctt ctcggccggc aacgccacaa    21840

cataaagaag caagcaacat caacaacagc tgccgccatg ggctccagtg agcaggaact    21900

gaaagccatt gtcaaagatc ttggttgtgg gccatatttt ttgggcacct atgacaagcg    21960

ctttccaggc tttgtttctc cacacaagct cgcctgcgcc atagtcaata cggccggtcg    22020

cgagactggg ggcgtacact ggatggcctt tgcctggaac ccgcactcaa aaacatgcta    22080

cctctttgag ccctttggct tttctgacca gcgactcaag caggtttacc agtttgagta    22140

cgagtcactc ctgcgccgta gcgccattgc ttcttccccc gaccgctgta taacgctgga    22200

aaagtccacc caaagcgtac aggggcccaa ctcggccgcc tgtggactat tctgctgcat    22260

gtttctccac gcctttgcca actggcccca aactcccatg gatcacaacc ccaccatgaa    22320

ccttattacc ggggtaccca actccatgct caacagtccc caggtacagc ccaccctgcg    22380

tcgcaaccag gaacagctct acagcttcct ggagcgccac tcgccctact tccgcagcca    22440

cagtgcgcag attaggagcg ccacttcttt ttgtcacttg aaaaacatgt aaaaataatg    22500

tactagagac actttcaata aaggcaaatg cttttatttg tacactctcg ggtgattatt    22560

tacccccacc cttgccgtct gcgccgttta aaaatcaaag gggttctgcc gcgcatcgct    22620

atgcgccact ggcagggaca cgttgcgata ctggtgttta gtgctccact taaactcagg    22680

cacaaccatc cgcggcagct cggtgaagtt ttcactccac aggctgcgca ccatcaccaa    22740

cgcgtttagc aggtcgggcg ccgatatctt gaagtcgcag ttggggcctc cgccctgcgc    22800

gcgcgagttg cgatacacag ggttgcagca ctggaacact atcagcgccg ggtggtgcac    22860

gctggccagc acgctcttgt cggagatcag atccgcgtcc aggtcctccg cgttgctcag    22920

ggcgaacgga gtcaactttg gtagctgcct tcccaaaaag ggcgcgtgcc caggctttga    22980

gttgcactcg caccgtagtg gcatcaaaag gtgaccgtgc ccggtctggg cgttaggata    23040

cagcgcctgc ataaaagcct tgatctgctt aaaagccacc tgagcctttg cgccttcaga    23100

gaagaacatg ccgcaagact tgccggaaaa ctgattggcc ggacaggccg cgtcgtgcac    23160

gcagcacctt gcgtcggtgt tggagatctg caccacattt cggccccacc ggttcttcac    23220

gatcttggcc ttgctagact gctccttcag cgcgcgctgc ccgttttcgc tcgtcacatc    23280

catttcaatc acgtgctcct tatttatcat aatgcttccg tgtagacact taagctcgcc    23340

ttcgatctca gcgcagcggt gcagccacaa cgcgcagccc gtgggctcgt gatgcttgta    23400

ggtcacctct gcaaacgact gcaggtacgc ctgcaggaat cgccccatca tcgtcacaaa    23460

ggtcttgttg ctggtgaagg tcagctgcaa cccgcggtgc tcctcgttca gccaggtctt    23520

gcatacggcc gccagagctt ccacttggtc aggcagtagt ttgaagttcg cctttagatc    23580

gttatccacg tggtacttgt ccatcagcgc gcgcgcagcc tccatgccct tctcccacgc    23640

agacacgatc ggcacactca gcgggttcat caccgtaatt tcactttccg cttcgctggg    23700

ctcttcctct tcctcttgcg tccgcatacc acgcgccact gggtcgtctt cattcagccg    23760

ccgcactgtg cgcttacctc ctttgccatg cttgattagc accggtgggt tgctgaaacc    23820

caccatttgt agcgccacat cttctctttc ttcctcgctg tccacgatta cctctggtga    23880

tggcgggcgc tcgggcttgg gagaagggcg cttctttttc ttcttgggcg caatggccaa    23940

atccgccgcc gaggtcgatg gccgcgggct gggtgtgcgc ggcaccagcg cgtcttgtga    24000

tgagtcttcc tcgtcctcgg actcgatacg ccgcctcatc cgcttttttg ggggcgcccg    24060

gggaggcggc ggcgacgggg acggggacga cacgtcctcc atggttgggg gacgtcgcgc    24120

cgcaccgcgt ccgcgctcgg gggtggtttc gcgctgctcc tcttcccgac tggccatttc    24180

cttctcctat aggcagaaaa agatcatgga gtcagtcgag aagaaggaca gcctaaccgc    24240

cccctctgag ttcgccacca ccgcctccac cgatgccgcc aacgcgccta ccaccttccc    24300

cgtcgaggca cccccgcttg aggaggagga agtgattatc gagcaggacc caggttttgt    24360

aagcgaagac gacgaggacc gctcagtacc aacagaggat aaaaagcaag accaggacaa    24420

cgcagaggca aacgaggaac aagtcgggcg gggggacgaa aggcatggcg actacctaga    24480

tgtgggagac gacgtgctgt tgaagcatct gcagcgccag tgcgccatta tctgcgacgc    24540

gttgcaagag cgcagcgatg tgcccctcgc catagcggat gtcagccttg cctacgaacg    24600

ccacctattc tcaccgcgcg taccccccaa acgccaagaa aacggcacat gcgagcccaa    24660

cccgcgcctc aacttctacc ccgtatttgc cgtgccagag gtgcttgcca cctatcacat    24720

ctttttccaa aactgcaaga tacccctatc ctgccgtgcc aaccgcagcc gagcggacaa    24780

gcagctggcc ttgcggcagg gcgctgtcat acctgatatc gcctcgctca acgaagtgcc    24840

aaaaatcttt gagggtcttg gacgcgacga gaagcgcgcg gcaaacgctc tgcaacagga    24900

aaacagcgaa aatgaaagtc actctggagt gttggtggaa ctcgagggtg acaacgcgcg    24960

cctagccgta ctaaaacgca gcatcgaggt cacccacttt gcctacccgg cacttaacct    25020

accccccaag gtcatgagca cagtcatgag tgagctgatc gtgcgccgtg cgcagcccct    25080

ggagagggat gcaaatttgc aagaacaaac agaggagggc ctacccgcag ttggcgacga    25140

gcagctagcg cgctggcttc aaacgcgcga gcctgccgac ttggaggagc gacgcaaact    25200

aatgatggcc gcagtgctcg ttaccgtgga gcttgagtgc atgcagcggt tctttgctga    25260

cccggagatg cagcgcaagc tagaggaaac attgcactac acctttcgac agggctacgt    25320

acgccaggcc tgcaagatct ccaacgtgga gctctgcaac ctggtctcct accttggaat    25380

tttgcacgaa aaccgccttg ggcaaaacgt gcttcattcc acgctcaagg gcgaggcgcg    25440

ccgcgactac gtccgcgact gcgtttactt atttctatgc tacacctggc agacggccat    25500

gggcgtttgg cagcagtgct tggaggagtg caacctcaag gagctgcaga aactgctaaa    25560

gcaaaacttg aaggacctat ggacggcctt caacgagcgc tccgtggccg cgcacctggc    25620

ggacatcatt ttccccgaac gcctgcttaa aaccctgcaa cagggtctgc cagacttcac    25680

cagtcaaagc atgttgcaga actttaggaa ctttatccta gagcgctcag gaatcttgcc    25740

cgccacctgc tgtgcacttc ctagcgactt tgtgcccatt aagtaccgcg aatgccctcc    25800

gccgctttgg ggccactgct accttctgca gctagccaac taccttgcct accactctga    25860

cataatggaa gacgtgagcg gtgacggtct actggagtgt cactgtcgct gcaacctatg    25920

caccccgcac cgctccctgg tttgcaattc gcagctgctt aacgaaagtc aaattatcgg    25980

tacctttgag ctgcagggtc cctcgcctga cgaaaagtcc gcggctccgg ggttgaaact    26040

cactccgggg ctgtggacgt cggcttacct tcgcaaattt gtacctgagg actaccacgc    26100

ccacgagatt aggttctacg aagaccaatc ccgcccgcca aatgcggagc ttaccgcctg    26160

cgtcattacc cagggccaca ttcttggcca attgcaagcc atcaacaaag cccgccaaga    26220

gtttctgcta cgaaagggac ggggggttta cttggacccc cagtccggcg aggagctcaa    26280

cccaatcccc ccgccgccgc agccctatca gcagcagccg cgggcccttg cttcccagga    26340

tggcacccaa aaagaagctg cagctgccgc cgccacccac ggacgaggag gaatactggg    26400

acagtcaggc agaggaggtt ttggacgagg aggaggagga catgatggaa gactgggaga    26460

gcctagacga ggaagcttcc gaggtcgaag aggtgtcaga cgaaacaccg tcaccctcgg    26520

tcgcattccc ctcgccggcg ccccagaaat cggcaaccgg ttccagcatg gctacaacct    26580

ccgctcctca ggcgccgccg gcactgcccg ttcgccgacc caaccgtaga tgggacacca    26640

ctggaaccag ggccggtaag tccaagcagc cgccgccgtt agcccaagag caacaacagc    26700

gccaaggcta ccgctcatgg cgcgggcaca agaacgccat agttgcttgc ttgcaagact    26760

gtgggggcaa catctccttc gcccgccgct ttcttctcta ccatcacggc gtggccttcc    26820

cccgtaacat cctgcattac taccgtcatc tctacagccc atactgcacc ggcggcagcg    26880

gcagcggcag caacagcagc ggccacacag aagcaaaggc gaccggatag caagactctg    26940

acaaagccca agaaatccac agcggcggca gcagcaggag gaggagcgct gcgtctggcg    27000

cccaacgaac ccgtatcgac ccgcgagctt agaaacagga tttttcccac tctgtatgct    27060

atatttcaac agagcagggg ccaagaacaa gagctgaaaa taaaaaacag gtctctgcga    27120

tccctcaccc gcagctgcct gtatcacaaa agcgaagatc agcttcggcg cacgctggaa    27180

gacgcggagg ctctcttcag taaatactgc gcgctgactc ttaaggacta gtttcgcgcc    27240

ctttctcaaa tttaagcgcg aaaactacgt catctccagc ggccacaccc ggcgccagca    27300

cctgtcgtca gcgccattat gagcaaggaa attcccacgc cctacatgtg gagttaccag    27360

ccacaaatgg gacttgcggc tggagctgcc caagactact caacccgaat aaactacatg    27420

agcgcgggac cccacatgat atcccgggtc aacggaatcc gcgcccaccg aaaccgaatt    27480

ctcttggaac aggcggctat taccaccaca cctcgtaata accttaatcc ccgtagttgg    27540

cccgctgccc tggtgtacca ggaaagtccc gctcccacca ctgtggtact tcccagagac    27600

gcccaggccg aagttcagat gactaactca ggggcgcagc ttgcgggcgg ctttcgtcac    27660

agggtgcggt cgcccgggca gggtataact cacctgacaa tcagagggcg aggtattcag    27720

ctcaacgacg agtcggtgag ctcctcgctt ggtctccgtc cggacgggac atttcagatc    27780

ggcggcgccg gccgctcttc attcacgcct cgtcaggcaa tcctaactct gcagacctcg    27840

tcctctgagc cgcgctctgg aggcattgga actctgcaat ttattgagga gtttgtgcca    27900

tcggtctact ttaacccctt ctcgggacct cccggccact atccggatca atttattcct    27960

aactttgacg cggtaaagga ctcggcggat ggctacgact gaatgttaag tggagaggca    28020

gagcaactgc gcctgaaaca cctggtccac tgtcgccgcc acaagtgctt tgcccgcgac    28080

tccggtgagt tttgctactt tgaattgccc gaggatcata tcgagggccc ggcgcacggc    28140

gtccggctta ccgcccaggg agagcttgcc cgtagcctga ttcgggagtt tacccagcgc    28200

cccctgctag ttgagcggga caggggaccc tgtgttctca ctgtgatttg caactgtcct    28260

aaccctggat tacatcaaga tctttgttgc catctctgtg ctgagtataa taaatacaga    28320

aattaaaata tactggggct cctatcgcca tcctgtaaac gccaccgtct tcacccgccc    28380

aagcaaacca aggcgaacct tacctggtac ttttaacatc tctccctctg tgatttacaa    28440

cagtttcaac ccagacggag tgagtctacg agagaacctc tccgagctca gctactccat    28500

cagaaaaaac accaccctcc ttacctgccg ggaacgtacg acctagggat aacagggtaa    28560

taagcaattg actctatgtg ggatatgctc cagcgctaca accttgaagt caggcttcct    28620

ggatgtcagc atctgacttt ggccagcacc tgtcccgcgg atttgttcca gtccaactac    28680

agcgacccac cctaacagag atgaccaaca caaccaacgc ggccgccgct accggactta    28740

catctaccac aaatacaccc caagtttctg cctttgtcaa taactgggat aacttgggca    28800

tgtggtggtt ctccatagcg cttatgtttg tatgccttat tattatgtgg ctcatctgct    28860

gcctaaagcg caaacgcgcc cgaccaccca tctatagtcc catcattgtg ctacacccaa    28920

acaatgatgg aatccataga ttggacggac tgaaacacat gttcttttct cttacagtat    28980

gattaaatga gacatgattc ctcgagtttt tatattactg acccttgttg cgcttttttg    29040

tgcgtgctcc acattggctg cggtttctca catcgaagta gactgcattc cagccttcac    29100

agtctatttg ctttacggat ttgtcaccct cacgctcatc tgcagcctca tcactgtggt    29160

catcgccttt atccagtgca ttgactgggt ctgtgtgcgc tttgcatatc tcagacacca    29220

tccccagtac agggacagga ctatagctga gcttcttaga attctttaat tatgaaattt    29280

actgtgactt ttctgctgat tatttgcacc ctatctgcgt tttgttcccc gacctccaag    29340

cctcaaagac atatatcatg cagattcact cgtatatgga atattccaag ttgctacaat    29400

gaaaaaagcg atctttccga agcctggtta tatgcaatca tctctgttat ggtgttctgc    29460

agtaccatct tagccctagc tatatatccc taccttgaca ttggctggaa acgaatagat    29520

gccatgaacc acccaacttt ccccgcgccc gctatgcttc cactgcaaca agttgttgcc    29580

ggcggctttg tcccagccaa tcagcctcgc cccacttctc ccacccccac tgaaatcagc    29640

tactttaatc taacaggagg agatgactga caccctagat ctagaaatgg acggaattat    29700

tacagagcag cgcctgctag aaagacgcag ggcagcggcc gagcaacagc gcatgaatca    29760

agagctccaa gacatggtta acttgcacca gtgcaaaagg ggtatctttt gtctggtaaa    29820

gcaggccaaa gtcacctacg acagtaatac caccggacac cgccttagct acaagttgcc    29880

aaccaagcgt cagaaattgg tggtcatggt gggagaaaag cccattacca taactcagca    29940

ctcggtagaa accgaaggct gcattcactc accttgtcaa ggacctgagg atctctgcac    30000

ccttattaag accctgtgcg gtctcaaaga tcttattccc tttaactaat aaaaaaaaat    30060

aataaagcat cacttactta aaatcagtta gcaaatttct gtccagttta ttcagcagca    30120

cctccttgcc ctcctcccag ctctggtatt gcagcttcct cctggctgca aactttctcc    30180

acaatctaaa tggaatgtca gtttcctcct gttcctgtcc atccgcaccc actatcttca    30240

tgttgttgca gatgaagcgc gcaagaccgt ctgaagatac cttcaacccc gtgtatccat    30300

atgacacgga aaccggtcct ccaactgtgc cttttcttac tcctcccttt gtatccccca    30360

atgggtttca agagagtccc cctggggtac tctctttgcg cctatccgaa cctctagtta    30420

cctccaatgg catgcttgcg ctcaaaatgg gcaacggcct ctctctggac gaggccggca    30480

accttacctc ccaaaatgta accactgtga gcccacctct caaaaaaacc aagtcaaaca    30540

taaacctgga aatatctgca cccctcacag ttacctcaga agccctaact gtggctgccg    30600

ccgcacctct aatggtcgcg ggcaacacac tcaccatgca atcacaggcc ccgctaaccg    30660

tgcacgactc caaacttagc attgccaccc aaggacccct cacagtgtca gaaggaaagc    30720

tagccctgca aacatcaggc cccctcacca ccaccgatag cagtaccctt actatcactg    30780

cctcaccccc tctaactact gccactggta gcttgggcat tgacttgaaa gagcccattt    30840

atacacaaaa tggaaaacta ggactaaagt acggggctcc tttgcatgta acagacgacc    30900

taaacacttt gaccgtagca actggtccag gtgtgactat taataatact tccttgcaaa    30960

ctaaagttac tggagccttg ggttttgatt cacaaggcaa tatgcaactt aatgtagcag    31020

gaggactaag gattgattct caaaacagac gccttatact tgatgttagt tatccgtttg    31080

atgctcaaaa ccaactaaat ctaagactag gacagggccc tctttttata aactcagccc    31140

acaacttgga tattaactac aacaaaggcc tttacttgtt tacagcttca aacaattcca    31200

aaaagcttga ggttaaccta agcactgcca aggggttgat gtttgacgct acagccatag    31260

ccattaatgc aggagatggg cttgaatttg gttcacctaa tgcaccaaac acaaatcccc    31320

tcaaaacaaa aattggccat ggcctagaat ttgattcaaa caaggctatg gttcctaaac    31380

taggaactgg ccttagtttt gacagcacag gtgccattac agtaggaaac aaaaataatg    31440

ataagctaac cctatggaca ggtccaaaac cagaagccaa ctgcataatt gaatacggga    31500

aacaaaaccc agatagcaaa ctaactttaa tccttgtaaa aaatggagga attgttaatg    31560

gatatgtaac gctaatggga gcctcagact acgttaacac cttatttaaa aacaaaaatg    31620

tctccattaa tgtagaacta tactttgatg ccactggtca tatattacca gactcatctt    31680

ctcttaaaac agatctagaa ctaaaataca agcaaaccgc tgactttagt gcaagaggtt    31740

ttatgccaag tactacagcg tatccatttg tccttcctaa tgcgggaaca cataatgaaa    31800

attatatttt tggtcaatgc tactacaaag caagcgatgg tgcccttttt ccgttggaag    31860

ttactgttat gcttaataaa cgcctgccag atagtcgcac atcctatgtt atgacttttt    31920

tatggtcctt gaatgctggt ctagctccag aaactactca ggcaaccctc ataacctccc    31980

catttacctt ttcctatatt agagaagatg actaataaac tctaaagaat cgtttgtgtt    32040

atgtttcaac gtgtttattt ttcaattgca gaaaatttca agtcattttt cattcagtag    32100

tatagcccca ccaccacata gcttatacag atcaccgtac cttaatcaaa ctcacagaac    32160

cctagtattc aacctgccac ctccctccca acacacagag tacacagtcc tttctccccg    32220

gctggcctta aaaagcatca tatcatgggt aacagacata ttcttaggtg ttatattcca    32280

cacggtttcc tgtcgagcca aacgctcatc aagtgatatt aataaactcc ccgggcagct    32340

cacttaagtt catgtcgctg tccagctgct gagccacagg ctgctgtcca acttgcggtt    32400

gcttaacggg cggcgaagga gaagtccacg cctacatggg gggagagtca taatcgtgca    32460

tcaggatagg gcggtggtgc tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg    32520

tcctgcagga atacaacatg gcagtggtct cctcagcgat gattcgcacc gcccgcagca    32580

taaggcgctt gtcctccggg cacagcagcg caccctgatc tcacttaaat cagcacagta    32640

actgcagcac agcaccacaa tattgttcaa aatcccacag tgcaaggcgc tgtatccaaa    32700

gctcatggcg gggaccacag aacccacgtg gccatcatac cacaagcgca ggtagattaa    32760

gtggcgaccc ctcataaaca cgctggacat aaacattacc tcttttggca tgttgtaatt    32820

caccacctcc cggtaccata taaacctctg attaaacatg gcgccatcca ccaccatcct    32880

aaaccagctg gccaaaacct gccccgccgg gntatacact gcagggaacc gggacttgga    32940

caatgacaag tgggagagcc caggactcgt aaccatggat catcatgctc gtcatgatat    33000

caatgttggc acaacacagg cacacgtgca tacacttcct caggattaca agctcctccc    33060

gcgttagaac catatcccag ggaacaaccc attcctgaat cagcgtaaat cccacactgc    33120

agggaagacc tcgcacgtaa ctcacgttgt gcattgtcaa agtgttacat tcgggcagca    33180

gcggatgatc ctccagtatg gtagcgcggg tttctgtctc aaaaggaggt agacgatccc    33240

tactgtacgg agtgcgccga gacaaccgag atcgtgttgg tcgtagtgtc atgccaaatg    33300

gaacgccgga cgtagtcata tttcctgaag caaaaccagg tgcgggcgtg acaaacagat    33360

ctgcgtctcc ggtctcgccg cttagatcgc tctgtgtagt agttgtagta tatccactct    33420

ctcaaagcat ccaggcgccc cctggcttcg ggttctatgt aaactccttc atgcgccgct    33480

gccctgataa catccaccac cgcagaataa gccacaccca gccaacctac acattcgttc    33540

tgcgagtcac acacgggagg agcgggaaga gctggaagaa ccatgttttt ttttttattc    33600

caaaagatta tccaaaacct caaaatgaag atctattaag tgaacgcgct cccctccggt    33660

ggcgtggtca aactctacag ccaaagaaca gataatggca tttgtaagat gttgcacaat    33720

ggcttccaaa aggcaaacgg ccctcacgtc caagtggacg taaaggctaa acccttcagg    33780

gtgaatctcc tctataaaca ttccagcacc ttcaaccatg cccaaataat tctcatctcg    33840

ccaccttctc aatatatctc taagcaaatc ccgaatattt aagtccgggc cattgtaaaa    33900

aatttggctc cagagcgccc tccaccttca gcctcaagca gcgaatcatg attgcaaaaa    33960

ttcaggttcc tcacagacct gtataagatt caaaagcgga acattaacaa aaataccgcg    34020

atcccgtagg tcccttcgca gggccagctg aacataatcg tgcaggtctg cacggaccag    34080

cgcggccact tccccgccag gaaccatgac aaaagaaccc acactgatta tgacacgcat    34140

actcggagct atgctaacca gcgtagcccc gatgtaagct tgttgcatgg gcggcgatat    34200

aaaatgcaag gtgctgctca aaaaatcagg caaagcctcg cgcaaaaaag aaagcacatc    34260

gtagtcatgc tcatgcagat aaaggcaggt aagctccgga accaccacag aaaaagacac    34320

catttttctc tcaaacatgt ctgcgggttt ctgcataaac acaaaataaa ataacaaaaa    34380

aacatttaaa cattagaagc ctgtcttaca acaggaaaaa caacccttat aagcataaga    34440

cggactacgg ccatgccggc gtgaccgtaa aaaaactggt caccgtgatt aaaaagcacc    34500

accgacagct cctcggtcag tccggagtca taatgtaaga ctcggtaaac acatcaggtt    34560

gattcacatc ggtcagtgtt aaaaagcgac cgaaatagcc ngggggaata caatacccgc    34620

aggcgtagag acaacattac agcccccata ggaggtataa caaaattaat aggagagaaa    34680

aacacataaa cacctgaaaa accctcctgc ctaggcaaaa tagcaccctc ccgctccaga    34740

acaacataca gcgcttccac agcggcagcc ataacagtca gccttaccag taaaaaagaa    34800

aacctattaa aaaaacacca ctcgacacgg caccagctca atcagtcaca gtgtaaaaaa    34860

gggccaagtg cagagcgagt atatatagga ctaaaaaatg acggtaacgg ttaaagtcca    34920

caaaaaacac ccagaaaacc gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc    34980

acaacttcct caaatcgtca cttccgtttt cccacgttac gtcacttccc attttaagaa    35040

aactacaatt cccaacacat acaagttact ccgccctaaa acctacgtca cccgccccgt    35100

tcccacgccc cgcgccacgt cacaaactcc accccctcat tatcatattg gcttcaatcc    35160

aaaataaggt atattattga tgatgttaat taacatgcat ggatcctcgt ctcgacgatg    35220

cccttgagag ccttcaaccc agtcagctcc ttccggtggg cgcggggcat gactatcgtc    35280

gccgcactta tgactgtctt ctttatcatg caactcgtag gacaggtgcc ggcagcgctc    35340

tgggtcattt tcggcgagga ccgctttcgc tggagcgcga cgatgatcgg cctgtcgctt    35400

gcggtattcg gaatcttgca cgccctcgct caagccttcg tcactggtcc cgccaccaaa    35460

cgtttcggcg agaagcaggc cattatcgcc ggcatggcgg ccgacgcgct gggctacgtc    35520

ttgctggcgt tcgcgacgcg aggctggatg gccttcccca ttatgattct tctcgcttcc    35580

ggcggcatcg ggatgcccgc gttgcaggcc atgctgtcca ggcaggtaga tgacgaccat    35640

cagggacagc ttcaaggatc gctcgcggct cttaccagcc taacttcgat cactggaccg    35700

ctgatcgtca cggcgattta tgccgcctcg gcgagcacat ggaacgggtt ggcatggatt    35760

gtaggcgccg ccctatacct tgtctgcctc cccgcgttgc gtcgcggtgc atggagccgg    35820

gccacctcga cctgaatgga agccggcggc acctcgctaa cggattcacc actccaagaa    35880

ttggagccaa tcaattcttg cggagaactg tgaatgcgca aaccaaccct tggcagaaca    35940

tatccatcgc gtccgccatc tccagcagcc gcacgcggcg catctcgggc agcgttgggt    36000

cctggccacg ggtgcgcatg atcgtgctcc tgtcgttgag gacccggcta ggctggcggg    36060

gttgccttac tggttagcag aatgaatcac cgatacgcga gcgaacgtga agcgactgct    36120

gctgcaaaac gtctgcgacc tgagcaacaa catgaatggt cttcggtttc cgtgtttcgt    36180

aaagtctgga aacgcggaag tcagcgccct gcaccattat gttccggatc tgcatcgcag    36240

gatgctgctg gctaccctgt ggaacaccta catctgtatt aacgaagcgc tggcattgac    36300

cctgagtgat ttttctctgg tcccgccgca tccataccgc cagttgttta ccctcacaac    36360

gttccagtaa ccgggcatgt tcatcatcag taacccgtat cgtgagcatc ctctctcgtt    36420

tcatcggtat cattaccccc atgaacagaa attccccctt acacggaggc atcaagtgac    36480

caaacaggaa aaaaccgccc ttaacatggc ccgctttatc agaagccaga cattaacgct    36540

tctggagaaa ctcaacgagc tggacgcgga tgaacaggca gacatctgtg aatcgcttca    36600

cgaccacgct gatgagcttt accgcagctg cctcgcgcgt ttcggtgatg acggtgaaaa    36660

cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg atgccgggag    36720

cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggcg cagccatgac    36780

ccagtcacgt agcgatagcg gagtgtatac tggcttaact atgcggcatc agagcagatt    36840

gtactgagag tgcaccatat gcggtgtgaa ataccgcaca gatgcgtaag gagaaaatac    36900

cgcatcaggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg    36960

cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat    37020

aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc    37080

gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc    37140

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga    37200

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt    37260

ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct gtaggtatct cagttcggtg    37320

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc    37380

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg    37440

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc    37500

ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg    37560

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc    37620

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct    37680

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt    37740

taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa    37800

aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa    37860

tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc    37920

tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct    37980

gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca    38040

gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt    38100

aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttggt    38160

tgnnnnnnaa aaaggatctt cacctagatc cttttcacgt agaaagccag tccgcagaaa    38220

cggtgctgac cccggatgaa tgtcagctac tgggctatct ggacaaggga aaacgcaagc    38280

gcaaagagaa agcaggtagc ttgcagtggg cttacatggc gatagctaga ctgggcggtt    38340

ttatggacag caagcgaacc ggaattgcca gctggggcgc cctctggtaa ggttgggaag    38400

ccctgcaaag taaactggat ggctttctcg ccgccaagga tctgatggcg caggggatca    38460

agctctgatc aagagacagg atgaggatcg tttcgcatga ttgaacaaga tggattgcac    38520

gcaggttctc cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca    38580

atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt    38640

gtcaagaccg acctgtccgg tgccctgaat gaactgcaag acgaggcagc gcggctatcg    38700

tggctggcca cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga    38760

agggactggc tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct    38820

cctgccgaga aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg    38880

gctacctgcc cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg    38940

gaagccggtc ttgtcgatca ggatgatctg gacgaagagc atcaggggct cgcgccagcc    39000

gaactgttcg ccaggctcaa ggcgagcatg cccgacggcg aggatctcgt cgtgacccat    39060

ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac    39120

tgtggccggc tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt    39180

gctgaagagc ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct    39240

cccgattcgc agcgcatcgc cttctatcgc cttcttgacg agttcttctg aattttgtta    39300

aaatttttgt taaatcagct cattttttaa ccaataggcc gaaatcggca acatccctta    39360

taaatcaaaa gaatagaccg cgatagggtt gagtgttgtt ccagtttgga acaagagtcc    39420

actattaaag aacgtggact ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg    39480

cccactacgt gaaccatcac ccaaatcaag ttttttgcgg tcgaggtgcc gtaaagctct    39540

aaatcggaac cctaaaggga gcccccgatt tagagcttga cggggaaagc cggcgaacgt    39600

ggcgagaaag gaagggaaga aagcgaaagg agcgggcgct agggcgctgg caagtgtagc    39660

ggtcacgctg cgcgtaacca ccacacccgc gcgcttaatg cgccgctaca gggcgcgtcc    39720

attcgccatt caggatcgaa ttaattctta at                                  39752


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acids 121-128 of Ad E1A protein

<400>  52

Leu Thr Cys His Glu Ala Cys Phe 
1               5               


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT1 binding site (1)

<400>  53

Thr Thr Cys Cys Gly Gly Gly Ala Ala 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT1 binding site (2)

<400>  54

Thr Thr Cys Thr Cys Gly Gly Ala Ala 
1               5                   


<210>  55
<211>  35010
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ad5/3Ad2E1Adelta24

<400>  55
taacatcatc aataatatac cttattttgg attgaagcca atatgataat gagggggtgg       60

agtttgtgac gtggcgcggg gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag      120

tgtgatgttg caagtgtggc ggaacacatg taagcgacgg atgtggcaaa agtgacgttt      180

ttggtgtgcg ccggtgtaca caggaagtga caattttcgc gcggttttag gcggatgttg      240

tagtaaattt gggcgtaacc gagtaagatt tggccatttt cgcgggaaaa ctgaataaga      300

ggaagtgaaa tctgaataat tttgtgttac tcatagcgcg taatatttgt ctagggccgc      360

ggggactttg accgtttacg tggagactcg cccaggtgtt tttctcaggt gttttccgcg      420

ttccgggtca aagttggcgt tttattatta tagtcagctg acgtgtagtg tatttatacc      480

cggtgagttc ctcaagaggc cactcttgag tgccagcgag tagagttttc tcctccgagc      540

cgctccgaca ccgggactga aaatgagaca tattatctgc cacggaggtg ttattaccga      600

agaaatggcc gccagtcttt tggaccagct gatcgaagag gtactggctg ataatcttcc      660

acctcctagc cattttgaac cacctaccct tcacgaactg tatgatttag acgtgacggc      720

ccccgaagat cccaacgagg aggcggtttc gcagattttt cccgagtctg taatgttggc      780

ggtgcaggaa gggattgact tattcacttt tccgccggcg cccggttctc cggagccgcc      840

tcacctttcc cggcagcccg agcagccgga gcagagagcc ttgggtccgg tttctatgcc      900

aaaccttgtg ccggaggtga tcgatccacc cagtgacgac gaggatgaag agggtgagga      960

gtttgtgtta gattatgtgg agcaccccgg gcacggttgc aggtcttgtc attatcaccg     1020

gaggaatacg ggggacccag atattatgtg ttcgctttgc tatatgagga cctgtggcat     1080

gtttgtctac agtaagtgaa aattatgggc agtcggtgat agagtggtgg gtttggtgtg     1140

gtaatttttt tttaattttt acagttttgt ggtttaaaga attttgtatt gtgatttttt     1200

aaaaggtcct gtgtctgaac ctgagcctga gcccgagcca gaaccggagc ctgcaagacc     1260

tacccggcgt cctaaattgg tgcctgctat cctgagacgc ccgacatcac ctgtgtctag     1320

agaatgcaat agtagtacgg atagctgtga ctccggtcct tctaacacac ctcctgagat     1380

acacccggtg gtcccgctgt gccccattaa accagttgcc gtgagagttg gtgggcgtcg     1440

ccaggctgtg gaatgtatcg aggacttgct taacgagtct gggcaacctt tggacttgag     1500

ctgtaaacgc cccaggccat aaggtgtaaa cctgtgattg cgtgtgtggt taacgccttt     1560

gtttgctgaa tgagttgatg taagtttaat aaagggtgag ataatgttta acttgcatgg     1620

cgtgttaaat ggggcggggc ttaaagggta tataatgcgc cgtgggctaa tcttggttac     1680

atctgacctc atggaggctt gggagtgttt ggaagatttt tctgctgtgc gtaacttgct     1740

ggaacagagc tctaacagta cctcttggtt ttggaggttt ctgtggggct catcccaggc     1800

aaagttagtc tgcagaatta aggaggatta caagtgggaa tttgaagagc ttttgaaatc     1860

ctgtggtgag ctgtttgatt ctttgaatct gggtcaccag gcgcttttcc aagagaaggt     1920

catcaagact ttggattttt ccacaccggg gcgcgctgcg gctgctgttg cttttttgag     1980

ttttataaag gataaatgga gcgaagaaac ccatctgagc ggggggtacc tgctggattt     2040

tctggccatg catctgtgga gagcggttgt gagacacaag aatcgcctgc tactgttgtc     2100

ttccgtccgc ccggcgataa taccgacgga ggagcagcag cagcagcagg aggaagccag     2160

gcggcggcgg caggagcaga gcccatggaa cccgagagcc ggcctggacc ctcgggaatg     2220

aatgttgttc aggtggctga actgtatcca gaactgagac gcattttgac aattacagag     2280

gatgggcagg ggctaaaggg ggtaaagagg gagcgggggg cttgtgaggc tacagaggag     2340

gctaggaatc tagcttttag cttaatgacc agacaccgtc ctgagtgtat tacttttcaa     2400

cagatcaagg ataattgcgc taatgagctt gatctgctgg cgcagaagta ttccatagag     2460

cagctgacca cttactggct gcagccaggg gatgattttg aggaggctat tagggtatat     2520

gcaaaggtgg cacttaggcc agattgcaag tacaagatca gcaaacttgt aaatatcagg     2580

aattgttgct acatttctgg gaacggggcc gaggtggaga tagatacgga ggatagggtg     2640

gcctttagat gtagcatgat aaatatgtgg ccgggggtgc ttggcatgga cggggtggtt     2700

attatgaatg taaggtttac tggccccaat tttagcggta cggttttcct ggccaatacc     2760

aaccttatcc tacacggtgt aagcttctat gggtttaaca atacctgtgt ggaagcctgg     2820

accgatgtaa gggttcgggg ctgtgccttt tactgctgct ggaagggggt ggtgtgtcgc     2880

cccaaaagca gggcttcaat taagaaatgc ctctttgaaa ggtgtacctt gggtatcctg     2940

tctgagggta actccagggt gcgccacaat gtggcctccg actgtggttg cttcatgcta     3000

gtgaaaagcg tggctgtgat taagcataac atggtatgtg gcaactgcga ggacagggcc     3060

tctcagatgc tgacctgctc ggacggcaac tgtcaccttc tgaagaccat tcacgtagcc     3120

agccactctc gcaaggcctg gccagtgttt gagcataaca tactgacccg ctgttccttg     3180

catttgggta acaggagggg ggtgttccta ccttaccaat gcaatttgag tcacactaag     3240

atattgcttg agcccgagag catgtccaag gtgaacctga acggggtgtt tgacatgacc     3300

atgaagatct ggaaggtgct gaggtacgat gagacccgca ccaggtgcag accctgcgag     3360

tgtggcggta aacatattag gaaccagcct gtgatgctgg atgtgaccga ggagctgagg     3420

cccgatcact tggtgctggc ctgcacccgc gctgagtttg gctctagcga tgaagataca     3480

gattgaggta ctgaaatgtg tgggcgtggc ttaagggtgg gaaagaatat ataaggtggg     3540

ggtcttatgt agttttgtat ctgttttgca gcagccgccg ccgccatgag caccaactcg     3600

tttgatggaa gcattgtgag ctcatatttg acaacgcgca tgcccccatg ggccggggtg     3660

cgtcagaatg tgatgggctc cagcattgat ggtcgccccg tcctgcccgc aaactctact     3720

accttgacct acgagaccgt gtctggaacg ccgttggaga ctgcagcctc cgccgccgct     3780

tcagccgctg cagccaccgc ccgcgggatt gtgactgact ttgctttcct gagcccgctt     3840

gcaagcagtg cagcttcccg ttcatccgcc cgcgatgaca agttgacggc tcttttggca     3900

caattggatt ctttgacccg ggaacttaat gtcgtttctc agcagctgtt ggatctgcgc     3960

cagcaggttt ctgccctgaa ggcttcctcc cctcccaatg cggtttaaaa cataaataaa     4020

aaaccagact ctgtttggat ttggatcaag caagtgtctt gctgtcttta tttaggggtt     4080

ttgcgcgcgc ggtaggcccg ggaccagcgg tctcggtcgt tgagggtcct gtgtattttt     4140

tccaggacgt ggtaaaggtg actctggatg ttcagataca tgggcataag cccgtctctg     4200

gggtggaggt agcaccactg cagagcttca tgctgcgggg tggtgttgta gatgatccag     4260

tcgtagcagg agcgctgggc gtggtgccta aaaatgtctt tcagtagcaa gctgattgcc     4320

aggggcaggc ccttggtgta agtgtttaca aagcggttaa gctgggatgg gtgcatacgt     4380

ggggatatga gatgcatctt ggactgtatt tttaggttgg ctatgttccc agccatatcc     4440

ctccggggat tcatgttgtg cagaaccacc agcacagtgt atccggtgca cttgggaaat     4500

ttgtcatgta gcttagaagg aaatgcgtgg aagaacttgg agacgccctt gtgacctcca     4560

agattttcca tgcattcgtc cataatgatg gcaatgggcc cacgggcggc ggcctgggcg     4620

aagatatttc tgggatcact aacgtcatag ttgtgttcca ggatgagatc gtcataggcc     4680

atttttacaa agcgcgggcg gagggtgcca gactgcggta taatggttcc atccggccca     4740

ggggcgtagt taccctcaca gatttgcatt tcccacgctt tgagttcaga tggggggatc     4800

atgtctacct gcggggcgat gaagaaaacg gtttccgggg taggggagat cagctgggaa     4860

gaaagcaggt tcctgagcag ctgcgactta ccgcagccgg tgggcccgta aatcacacct     4920

attaccgggt gcaactggta gttaagagag ctgcagctgc cgtcatccct gagcaggggg     4980

gccacttcgt taagcatgtc cctgactcgc atgttttccc tgaccaaatc cgccagaagg     5040

cgctcgccgc ccagcgatag cagttcttgc aaggaagcaa agtttttcaa cggtttgaga     5100

ccgtccgccg taggcatgct tttgagcgtt tgaccaagca gttccaggcg gtcccacagc     5160

tcggttacct gctctacggc atctcgatcc agcatatctc ctcgtttcgc gggttggggc     5220

ggctttcgct gtacggcagt agtcggtgct cgtccagacg ggccagggtc atgtctttcc     5280

acgggcgcag ggtcctcgtc agcgtagtct gggtcacggt gaaggggtgc gctccgggct     5340

gcgcgctggc cagggtgcgc ttgaggctgg tcctgctggt gctgaagcgc tgccggtctt     5400

cgccctgcgc gtcggccagg tagcatttga ccatggtgtc atagtccagc ccctccgcgg     5460

cgtggccctt ggcgcgcagc ttgcccttgg aggaggcgcc gcacgagggg cagtgcagac     5520

ttttgagggc gtagagcttg ggcgcgagaa ataccgattc cggggagtag gcatccgcgc     5580

cgcaggcccc gcagacggtc tcgcattcca cgagccaggt gagctctggc cgttcggggt     5640

caaaaaccag gtttccccca tgctttttga tgcgtttctt acctctggtt tccatgagcc     5700

ggtgtccacg ctcggtgacg aaaaggctgt ccgtgtcccc gtatacagac ttgagaggcc     5760

tgtcctcgag cggtgttccg cggtcctcct cgtatagaaa ctcggaccac tctgagacaa     5820

aggctcgcgt ccaggccagc acgaaggagg ctaagtggga ggggtagcgg tcgttgtcca     5880

ctagggggtc cactcgctcc agggtgtgaa gacacatgtc gccctcttcg gcatcaagga     5940

aggtgattgg tttgtaggtg taggccacgt gaccgggtgt tcctgaaggg gggctataaa     6000

agggggtggg ggcgcgttcg tcctcactct cttccgcatc gctgtctgcg agggccagct     6060

gttggggtga gtactccctc tgaaaagcgg gcatgacttc tgcgctaaga ttgtcagttt     6120

ccaaaaacga ggaggatttg atattcacct ggcccgcggt gatgcctttg agggtggccg     6180

catccatctg gtcagaaaag acaatctttt tgttgtcaag cttggtggca aacgacccgt     6240

agagggcgtt ggacagcaac ttggcgatgg agcgcagggt ttggtttttg tcgcgatcgg     6300

cgcgctcctt ggccgcgatg tttagctgca cgtattcgcg cgcaacgcac cgccattcgg     6360

gaaagacggt ggtgcgctcg tcgggcacca ggtgcacgcg ccaaccgcgg ttgtgcaggg     6420

tgacaaggtc aacgctggtg gctacctctc cgcgtaggcg ctcgttggtc cagcagaggc     6480

ggccgccctt gcgcgagcag aatggcggta gggggtctag ctgcgtctcg tccggggggt     6540

ctgcgtccac ggtaaagacc ccgggcagca ggcgcgcgtc gaagtagtct atcttgcatc     6600

cttgcaagtc tagcgcctgc tgccatgcgc gggcggcaag cgcgcgctcg tatgggttga     6660

gtgggggacc ccatggcatg gggtgggtga gcgcggaggc gtacatgccg caaatgtcgt     6720

aaacgtagag gggctctctg agtattccaa gatatgtagg gtagcatctt ccaccgcgga     6780

tgctggcgcg cacgtaatcg tatagttcgt gcgagggagc gaggaggtcg ggaccgaggt     6840

tgctacgggc gggctgctct gctcggaaga ctatctgcct gaagatggca tgtgagttgg     6900

atgatatggt tggacgctgg aagacgttga agctggcgtc tgtgagacct accgcgtcac     6960

gcacgaagga ggcgtaggag tcgcgcagct tgttgaccag ctcggcggtg acctgcacgt     7020

ctagggcgca gtagtccagg gtttccttga tgatgtcata cttatcctgt cccttttttt     7080

tccacagctc gcggttgagg acaaactctt cgcggtcttt ccagtactct tggatcggaa     7140

acccgtcggc ctccgaacgg taagagccta gcatgtagaa ctggttgacg gcctggtagg     7200

cgcagcatcc cttttctacg ggtagcgcgt atgcctgcgc ggccttccgg agcgaggtgt     7260

gggtgagcgc aaaggtgtcc ctgaccatga ctttgaggta ctggtatttg aagtcagtgt     7320

cgtcgcatcc gccctgctcc cagagcaaaa agtccgtgcg ctttttggaa cgcggatttg     7380

gcagggcgaa ggtgacatcg ttgaagagta tctttcccgc gcgaggcata aagttgcgtg     7440

tgatgcggaa gggtcccggc acctcggaac ggttgttaat tacctgggcg gcgagcacga     7500

tctcgtcaaa gccgttgatg ttgtggccca caatgtaaag ttccaagaag cgcgggatgc     7560

ccttgatgga aggcaatttt ttaagttcct cgtaggtgag ctcttcaggg gagctgagcc     7620

cgtgctctga aagggcccag tctgcaagat gagggttgga agcgacgaat gagctccaca     7680

ggtcacgggc cattagcatt tgcaggtggt cgcgaaaggt cctaaactgg cgacctatgg     7740

ccattttttc tggggtgatg cagtagaagg taagcgggtc ttgttcccag cggtcccatc     7800

caaggttcgc ggctaggtct cgcgcggcag tcactagagg ctcatctccg ccgaacttca     7860

tgaccagcat gaagggcacg agctgcttcc caaaggcccc catccaagta taggtctcta     7920

catcgtaggt gacaaagaga cgctcggtgc gaggatgcga gccgatcggg aagaactgga     7980

tctcccgcca ccaattggag gagtggctat tgatgtggtg aaagtagaag tccctgcgac     8040

gggccgaaca ctcgtgctgg cttttgtaaa aacgtgcgca gtactggcag cggtgcacgg     8100

gctgtacatc ctgcacgagg ttgacctgac gaccgcgcac aaggaagcag agtgggaatt     8160

tgagcccctc gcctggcggg tttggctggt ggtcttctac ttcggctgct tgtccttgac     8220

cgtctggctg ctcgagggga gttacggtgg atcggaccac cacgccgcgc gagcccaaag     8280

tccagatgtc cgcgcgcggc ggtcggagct tgatgacaac atcgcgcaga tgggagctgt     8340

ccatggtctg gagctcccgc ggcgtcaggt caggcgggag ctcctgcagg tttacctcgc     8400

atagacgggt cagggcgcgg gctagatcca ggtgatacct aatttccagg ggctggttgg     8460

tggcggcgtc gatggcttgc aagaggccgc atccccgcgg cgcgactacg gtaccgcgcg     8520

gcgggcggtg ggccgcgggg gtgtccttgg atgatgcatc taaaagcggt gacgcgggcg     8580

agcccccgga ggtagggggg gctccggacc cgccgggaga gggggcaggg gcacgtcggc     8640

gccgcgcgcg ggcaggagct ggtgctgcgc gcgtaggttg ctggcgaacg cgacgacgcg     8700

gcggttgatc tcctgaatct ggcgcctctg cgtgaagacg acgggcccgg tgagcttgag     8760

cctgaaagag agttcgacag aatcaatttc ggtgtcgttg acggcggcct ggcgcaaaat     8820

ctcctgcacg tctcctgagt tgtcttgata ggcgatctcg gccatgaact gctcgatctc     8880

ttcctcctgg agatctccgc gtccggctcg ctccacggtg gcggcgaggt cgttggaaat     8940

gcgggccatg agctgcgaga aggcgttgag gcctccctcg ttccagacgc ggctgtagac     9000

cacgccccct tcggcatcgc gggcgcgcat gaccacctgc gcgagattga gctccacgtg     9060

ccgggcgaag acggcgtagt ttcgcaggcg ctgaaagagg tagttgaggg tggtggcggt     9120

gtgttctgcc acgaagaagt acataaccca gcgtcgcaac gtggattcgt tgatatcccc     9180

caaggcctca aggcgctcca tggcctcgta gaagtccacg gcgaagttga aaaactggga     9240

gttgcgcgcc gacacggtta actcctcctc cagaagacgg atgagctcgg cgacagtgtc     9300

gcgcacctcg cgctcaaagg ctacaggggc ctcttcttct tcttcaatct cctcttccat     9360

aagggcctcc ccttcttctt cttctggcgg cggtggggga ggggggacac ggcggcgacg     9420

acggcgcacc gggaggcggt cgacaaagcg ctcgatcatc tccccgcggc gacggcgcat     9480

ggtctcggtg acggcgcggc cgttctcgcg ggggcgcagt tggaagacgc cgcccgtcat     9540

gtcccggtta tgggttggcg gggggctgcc atgcggcagg gatacggcgc taacgatgca     9600

tctcaacaat tgttgtgtag gtactccgcc gccgagggac ctgagcgagt ccgcatcgac     9660

cggatcggaa aacctctcga gaaaggcgtc taaccagtca cagtcgcaag gtaggctgag     9720

caccgtggcg ggcggcagcg ggcggcggtc ggggttgttt ctggcggagg tgctgctgat     9780

gatgtaatta aagtaggcgg tcttgagacg gcggatggtc gacagaagca ccatgtcctt     9840

gggtccggcc tgctgaatgc gcaggcggtc ggccatgccc caggcttcgt tttgacatcg     9900

gcgcaggtct ttgtagtagt cttgcatgag cctttctacc ggcacttctt cttctccttc     9960

ctcttgtcct gcatctcttg catctatcgc tgcggcggcg gcggagtttg gccgtaggtg    10020

gcgccctctt cctcccatgc gtgtgacccc gaagcccctc atcggctgaa gcagggctag    10080

gtcggcgaca acgcgctcgg ctaatatggc ctgctgcacc tgcgtgaggg tagactggaa    10140

gtcatccatg tccacaaagc ggtggtatgc gcccgtgttg atggtgtaag tgcagttggc    10200

cataacggac cagttaacgg tctggtgacc cggctgcgag agctcggtgt acctgagacg    10260

cgagtaagcc ctcgagtcaa atacgtagtc gttgcaagtc cgcaccaggt actggtatcc    10320

caccaaaaag tgcggcggcg gctggcggta gaggggccag cgtagggtgg ccggggctcc    10380

gggggcgaga tcttccaaca taaggcgatg atatccgtag atgtacctgg acatccaggt    10440

gatgccggcg gcggtggtgg aggcgcgcgg aaagtcgcgg acgcggttcc agatgttgcg    10500

cagcggcaaa aagtgctcca tggtcgggac gctctggccg gtcaggcgcg cgcaatcgtt    10560

gacgctctag accgtgcaaa aggagagcct gtaagcgggc actcttccgt ggtctggtgg    10620

ataaattcgc aagggtatca tggcggacga ccggggttcg agccccgtat ccggccgtcc    10680

gccgtgatcc atgcggttac cgcccgcgtg tcgaacccag gtgtgcgacg tcagacaacg    10740

ggggagtgct ccttttggct tccttccagg cgcggcggct gctgcgctag cttttttggc    10800

cactggccgc gcgcagcgta agcggttagg ctggaaagcg aaagcattaa gtggctcgct    10860

ccctgtagcc ggagggttat tttccaaggg ttgagtcgcg ggacccccgg ttcgagtctc    10920

ggaccggccg gactgcggcg aacgggggtt tgcctccccg tcatgcaaga ccccgcttgc    10980

aaattcctcc ggaaacaggg acgagcccct tttttgcttt tcccagatgc atccggtgct    11040

gcggcagatg cgcccccctc ctcagcagcg gcaagagcaa gagcagcggc agacatgcag    11100

ggcaccctcc cctcctccta ccgcgtcagg aggggcgaca tccgcggttg acgcggcagc    11160

agatggtgat tacgaacccc cgcggcgccg ggcccggcac tacctggact tggaggaggg    11220

cgagggcctg gcgcggctag gagcgccctc tcctgagcgg tacccaaggg tgcagctgaa    11280

gcgtgatacg cgtgaggcgt acgtgccgcg gcagaacctg tttcgcgacc gcgagggaga    11340

ggagcccgag gagatgcggg atcgaaagtt ccacgcaggg cgcgagctgc ggcatggcct    11400

gaatcgcgag cggttgctgc gcgaggagga ctttgagccc gacgcgcgaa ccgggattag    11460

tcccgcgcgc gcacacgtgg cggccgccga cctggtaacc gcatacgagc agacggtgaa    11520

ccaggagatt aactttcaaa aaagctttaa caaccacgtg cgtacgcttg tggcgcgcga    11580

ggaggtggct ataggactga tgcatctgtg ggactttgta agcgcgctgg agcaaaaccc    11640

aaatagcaag ccgctcatgg cgcagctgtt ccttatagtg cagcacagca gggacaacga    11700

ggcattcagg gatgcgctgc taaacatagt agagcccgag ggccgctggc tgctcgattt    11760

gataaacatc ctgcagagca tagtggtgca ggagcgcagc ttgagcctgg ctgacaaggt    11820

ggccgccatc aactattcca tgcttagcct gggcaagttt tacgcccgca agatatacca    11880

taccccttac gttcccatag acaaggaggt aaagatcgag gggttctaca tgcgcatggc    11940

gctgaaggtg cttaccttga gcgacgacct gggcgtttat cgcaacgagc gcatccacaa    12000

ggccgtgagc gtgagccggc ggcgcgagct cagcgaccgc gagctgatgc acagcctgca    12060

aagggccctg gctggcacgg gcagcggcga tagagaggcc gagtcctact ttgacgcggg    12120

cgctgacctg cgctgggccc caagccgacg cgccctggag gcagctgggg ccggacctgg    12180

gctggcggtg gcacccgcgc gcgctggcaa cgtcggcggc gtggaggaat atgacgagga    12240

cgatgagtac gagccagagg acggcgagta ctaagcggtg atgtttctga tcagatgatg    12300

caagacgcaa cggacccggc ggtgcgggcg gcgctgcaga gccagccgtc cggccttaac    12360

tccacggacg actggcgcca ggtcatggac cgcatcatgt cgctgactgc gcgcaatcct    12420

gacgcgttcc ggcagcagcc gcaggccaac cggctctccg caattctgga agcggtggtc    12480

ccggcgcgcg caaaccccac gcacgagaag gtgctggcga tcgtaaacgc gctggccgaa    12540

aacagggcca tccggcccga cgaggccggc ctggtctacg acgcgctgct tcagcgcgtg    12600

gctcgttaca acagcggcaa cgtgcagacc aacctggacc ggctggtggg ggatgtgcgc    12660

gaggccgtgg cgcagcgtga gcgcgcgcag cagcagggca acctgggctc catggttgca    12720

ctaaacgcct tcctgagtac acagcccgcc aacgtgccgc ggggacagga ggactacacc    12780

aactttgtga gcgcactgcg gctaatggtg actgagacac cgcaaagtga ggtgtaccag    12840

tctgggccag actatttttt ccagaccagt agacaaggcc tgcagaccgt aaacctgagc    12900

caggctttca aaaacttgca ggggctgtgg ggggtgcggg ctcccacagg cgaccgcgcg    12960

accgtgtcta gcttgctgac gcccaactcg cgcctgttgc tgctgctaat agcgcccttc    13020

acggacagtg gcagcgtgtc ccgggacaca tacctaggtc acttgctgac actgtaccgc    13080

gaggccatag gtcaggcgca tgtggacgag catactttcc aggagattac aagtgtcagc    13140

cgcgcgctgg ggcaggagga cacgggcagc ctggaggcaa ccctaaacta cctgctgacc    13200

aaccggcggc agaagatccc ctcgttgcac agtttaaaca gcgaggagga gcgcattttg    13260

cgctacgtgc agcagagcgt gagccttaac ctgatgcgcg acggggtaac gcccagcgtg    13320

gcgctggaca tgaccgcgcg caacatggaa ccgggcatgt atgcctcaaa ccggccgttt    13380

atcaaccgcc taatggacta cttgcatcgc gcggccgccg tgaaccccga gtatttcacc    13440

aatgccatct tgaacccgca ctggctaccg ccccctggtt tctacaccgg gggattcgag    13500

gtgcccgagg gtaacgatgg attcctctgg gacgacatag acgacagcgt gttttccccg    13560

caaccgcaga ccctgctaga gttgcaacag cgcgagcagg cagaggcggc gctgcgaaag    13620

gaaagcttcc gcaggccaag cagcttgtcc gatctaggcg ctgcggcccc gcggtcagat    13680

gctagtagcc catttccaag cttgataggg tctcttacca gcactcgcac cacccgcccg    13740

cgcctgctgg gcgaggagga gtacctaaac aactcgctgc tgcagccgca gcgcgaaaaa    13800

aacctgcctc cggcatttcc caacaacggg atagagagcc tagtggacaa gatgagtaga    13860

tggaagacgt acgcgcagga gcacagggac gtgccaggcc cgcgcccgcc cacccgtcgt    13920

caaaggcacg accgtcagcg gggtctggtg tgggaggacg atgactcggc agacgacagc    13980

agcgtcctgg atttgggagg gagtggcaac ccgtttgcgc accttcgccc caggctgggg    14040

agaatgtttt aaaaaaaaaa aagcatgatg caaaataaaa aactcaccaa ggccatggca    14100

ccgagcgttg gttttcttgt attcccctta gtatgcggcg cgcggcgatg tatgaggaag    14160

gtcctcctcc ctcctacgag agtgtggtga gcgcggcgcc agtggcggcg gcgctgggtt    14220

ctcccttcga tgctcccctg gacccgccgt ttgtgcctcc gcggtacctg cggcctaccg    14280

gggggagaaa cagcatccgt tactctgagt tggcacccct attcgacacc acccgtgtgt    14340

acctggtgga caacaagtca acggatgtgg catccctgaa ctaccagaac gaccacagca    14400

actttctgac cacggtcatt caaaacaatg actacagccc gggggaggca agcacacaga    14460

ccatcaatct tgacgaccgg tcgcactggg gcggcgacct gaaaaccatc ctgcatacca    14520

acatgccaaa tgtgaacgag ttcatgttta ccaataagtt taaggcgcgg gtgatggtgt    14580

cgcgcttgcc tactaaggac aatcaggtgg agctgaaata cgagtgggtg gagttcacgc    14640

tgcccgaggg caactactcc gagaccatga ccatagacct tatgaacaac gcgatcgtgg    14700

agcactactt gaaagtgggc agacagaacg gggttctgga aagcgacatc ggggtaaagt    14760

ttgacacccg caacttcaga ctggggtttg accccgtcac tggtcttgtc atgcctgggg    14820

tatatacaaa cgaagccttc catccagaca tcattttgct gccaggatgc ggggtggact    14880

tcacccacag ccgcctgagc aacttgttgg gcatccgcaa gcggcaaccc ttccaggagg    14940

gctttaggat cacctacgat gatctggagg gtggtaacat tcccgcactg ttggatgtgg    15000

acgcctacca ggcgagcttg aaagatgaca ccgaacaggg cgggggtggc gcaggcggca    15060

gcaacagcag tggcagcggc gcggaagaga actccaacgc ggcagccgcg gcaatgcagc    15120

cggtggagga catgaacgat catgccattc gcggcgacac ctttgccaca cgggctgagg    15180

agaagcgcgc tgaggccgaa gcagcggccg aagctgccgc ccccgctgcg caacccgagg    15240

tcgagaagcc tcagaagaaa ccggtgatca aacccctgac agaggacagc aagaaacgca    15300

gttacaacct aataagcaat gacagcacct tcacccagta ccgcagctgg taccttgcat    15360

acaactacgg cgaccctcag accggaatcc gctcatggac cctgctttgc actcctgacg    15420

taacctgcgg ctcggagcag gtctactggt cgttgccaga catgatgcaa gaccccgtga    15480

ccttccgctc cacgcgccag atcagcaact ttccggtggt gggcgccgag ctgttgcccg    15540

tgcactccaa gagcttctac aacgaccagg ccgtctactc ccaactcatc cgccagttta    15600

cctctctgac ccacgtgttc aatcgctttc ccgagaacca gattttggcg cgcccgccag    15660

cccccaccat caccaccgtc agtgaaaacg ttcctgctct cacagatcac gggacgctac    15720

cgctgcgcaa cagcatcgga ggagtccagc gagtgaccat tactgacgcc agacgccgca    15780

cctgccccta cgtttacaag gccctgggca tagtctcgcc gcgcgtccta tcgagccgca    15840

ctttttgagc aagcatgtcc atccttatat cgcccagcaa taacacaggc tggggcctgc    15900

gcttcccaag caagatgttt ggcggggcca agaagcgctc cgaccaacac ccagtgcgcg    15960

tgcgcgggca ctaccgcgcg ccctggggcg cgcacaaacg cggccgcact gggcgcacca    16020

ccgtcgatga cgccatcgac gcggtggtgg aggaggcgcg caactacacg cccacgccgc    16080

caccagtgtc cacagtggac gcggccattc agaccgtggt gcgcggagcc cggcgctatg    16140

ctaaaatgaa gagacggcgg aggcgcgtag cacgtcgcca ccgccgccga cccggcactg    16200

ccgcccaacg cgcggcggcg gccctgctta accgcgcacg tcgcaccggc cgacgggcgg    16260

ccatgcgggc cgctcgaagg ctggccgcgg gtattgtcac tgtgcccccc aggtccaggc    16320

gacgagcggc cgccgcagca gccgcggcca ttagtgctat gactcagggt cgcaggggca    16380

acgtgtattg ggtgcgcgac tcggttagcg gcctgcgcgt gcccgtgcgc acccgccccc    16440

cgcgcaacta gattgcaaga aaaaactact tagactcgta ctgttgtatg tatccagcgg    16500

cggcggcgcg caacgaagct atgtccaagc gcaaaatcaa agaagagatg ctccaggtca    16560

tcgcgccgga gatctatggc cccccgaaga aggaagagca ggattacaag ccccgaaagc    16620

taaagcgggt caaaaagaaa aagaaagatg atgatgatga acttgacgac gaggtggaac    16680

tgctgcacgc taccgcgccc aggcgacggg tacagtggaa aggtcgacgc gtaaaacgtg    16740

ttttgcgacc cggcaccacc gtagtcttta cgcccggtga gcgctccacc cgcacctaca    16800

agcgcgtgta tgatgaggtg tacggcgacg aggacctgct tgagcaggcc aacgagcgcc    16860

tcggggagtt tgcctacgga aagcggcata aggacatgct ggcgttgccg ctggacgagg    16920

gcaacccaac acctagccta aagcccgtaa cactgcagca ggtgctgccc gcgcttgcac    16980

cgtccgaaga aaagcgcggc ctaaagcgcg agtctggtga cttggcaccc accgtgcagc    17040

tgatggtacc caagcgccag cgactggaag atgtcttgga aaaaatgacc gtggaacctg    17100

ggctggagcc cgaggtccgc gtgcggccaa tcaagcaggt ggcgccggga ctgggcgtgc    17160

agaccgtgga cgttcagata cccactacca gtagcaccag tattgccacc gccacagagg    17220

gcatggagac acaaacgtcc ccggttgcct cagcggtggc ggatgccgcg gtgcaggcgg    17280

tcgctgcggc cgcgtccaag acctctacgg aggtgcaaac ggacccgtgg atgtttcgcg    17340

tttcagcccc ccggcgcccg cgcggttcga ggaagtacgg cgccgccagc gcgctactgc    17400

ccgaatatgc cctacatcct tccattgcgc ctacccccgg ctatcgtggc tacacctacc    17460

gccccagaag acgagcaact acccgacgcc gaaccaccac tggaacccgc cgccgccgtc    17520

gccgtcgcca gcccgtgctg gccccgattt ccgtgcgcag ggtggctcgc gaaggaggca    17580

ggaccctggt gctgccaaca gcgcgctacc accccagcat cgtttaaaag ccggtctttg    17640

tggttcttgc agatatggcc ctcacctgcc gcctccgttt cccggtgccg ggattccgag    17700

gaagaatgca ccgtaggagg ggcatggccg gccacggcct gacgggcggc atgcgtcgtg    17760

cgcaccaccg gcggcggcgc gcgtcgcacc gtcgcatgcg cggcggtatc ctgcccctcc    17820

ttattccact gatcgccgcg gcgattggcg ccgtgcccgg aattgcatcc gtggccttgc    17880

aggcgcagag acactgatta aaaacaagtt gcatgtggaa aaatcaaaat aaaaagtctg    17940

gactctcacg ctcgcttggt cctgtaacta ttttgtagaa tggaagacat caactttgcg    18000

tctctggccc cgcgacacgg ctcgcgcccg ttcatgggaa actggcaaga tatcggcacc    18060

agcaatatga gcggtggcgc cttcagctgg ggctcgctgt ggagcggcat taaaaatttc    18120

ggttccaccg ttaagaacta tggcagcaag gcctggaaca gcagcacagg ccagatgctg    18180

agggataagt tgaaagagca aaatttccaa caaaaggtgg tagatggcct ggcctctggc    18240

attagcgggg tggtggacct ggccaaccag gcagtgcaaa ataagattaa cagtaagctt    18300

gatccccgcc ctcccgtaga ggagcctcca ccggccgtgg agacagtgtc tccagagggg    18360

cgtggcgaaa agcgtccgcg ccccgacagg gaagaaactc tggtgacgca aatagacgag    18420

cctccctcgt acgaggaggc actaaagcaa ggcctgccca ccacccgtcc catcgcgccc    18480

atggctaccg gagtgctggg ccagcacaca cccgtaacgc tggacctgcc tccccccgcc    18540

gacacccagc agaaacctgt gctgccaggc ccgaccgccg ttgttgtaac ccgtcctagc    18600

cgcgcgtccc tgcgccgcgc cgccagcggt ccgcgatcgt tgcggcccgt agccagtggc    18660

aactggcaaa gcacactgaa cagcatcgtg ggtctggggg tgcaatccct gaagcgccga    18720

cgatgcttct gaatagctaa cgtgtcgtat gtgtgtcatg tatgcgtcca tgtcgccgcc    18780

agaggagctg ctgagccgcc gcgcgcccgc tttccaagat ggctacccct tcgatgatgc    18840

cgcagtggtc ttacatgcac atctcgggcc aggacgcctc ggagtacctg agccccgggc    18900

tggtgcagtt tgcccgcgcc accgagacgt acttcagcct gaataacaag tttagaaacc    18960

ccacggtggc gcctacgcac gacgtgacca cagaccggtc ccagcgtttg acgctgcggt    19020

tcatccctgt ggaccgtgag gatactgcgt actcgtacaa ggcgcggttc accctagctg    19080

tgggtgataa ccgtgtgctg gacatggctt ccacgtactt tgacatccgc ggcgtgctgg    19140

acaggggccc tacttttaag ccctactctg gcactgccta caacgccctg gctcccaagg    19200

gtgccccaaa tccttgcgaa tgggatgaag ctgctactgc tcttgaaata aacctagaag    19260

aagaggacga tgacaacgaa gacgaagtag acgagcaagc tgagcagcaa aaaactcacg    19320

tatttgggca ggcgccttat tctggtataa atattacaaa ggagggtatt caaataggtg    19380

tcgaaggtca aacacctaaa tatgccgata aaacatttca acctgaacct caaataggag    19440

aatctcagtg gtacgaaact gaaattaatc atgcagctgg gagagtcctt aaaaagacta    19500

ccccaatgaa accatgttac ggttcatatg caaaacccac aaatgaaaat ggagggcaag    19560

gcattcttgt aaagcaacaa aatggaaagc tagaaagtca agtggaaatg caatttttct    19620

caactactga ggcgaccgca ggcaatggtg ataacttgac tcctaaagtg gtattgtaca    19680

gtgaagatgt agatatagaa accccagaca ctcatatttc ttacatgccc actattaagg    19740

aaggtaactc acgagaacta atgggccaac aatctatgcc caacaggcct aattacattg    19800

cttttaggga caattttatt ggtctaatgt attacaacag cacgggtaat atgggtgttc    19860

tggcgggcca agcatcgcag ttgaatgctg ttgtagattt gcaagacaga aacacagagc    19920

tttcatacca gcttttgctt gattccattg gtgatagaac caggtacttt tctatgtgga    19980

atcaggctgt tgacagctat gatccagatg ttagaattat tgaaaatcat ggaactgaag    20040

atgaacttcc aaattactgc tttccactgg gaggtgtgat taatacagag actcttacca    20100

aggtaaaacc taaaacaggt caggaaaatg gatgggaaaa agatgctaca gaattttcag    20160

ataaaaatga aataagagtt ggaaataatt ttgccatgga aatcaatcta aatgccaacc    20220

tgtggagaaa tttcctgtac tccaacatag cgctgtattt gcccgacaag ctaaagtaca    20280

gtccttccaa cgtaaaaatt tctgataacc caaacaccta cgactacatg aacaagcgag    20340

tggtggctcc cgggttagtg gactgctaca ttaaccttgg agcacgctgg tcccttgact    20400

atatggacaa cgtcaaccca tttaaccacc accgcaatgc tggcctgcgc taccgctcaa    20460

tgttgctggg caatggtcgc tatgtgccct tccacatcca ggtgcctcag aagttctttg    20520

ccattaaaaa cctccttctc ctgccgggct catacaccta cgagtggaac ttcaggaagg    20580

atgttaacat ggttctgcag agctccctag gaaatgacct aagggttgac ggagccagca    20640

ttaagtttga tagcatttgc ctttacgcca ccttcttccc catggcccac aacaccgcct    20700

ccacgcttga ggccatgctt agaaacgaca ccaacgacca gtcctttaac gactatctct    20760

ccgccgccaa catgctctac cctatacccg ccaacgctac caacgtgccc atatccatcc    20820

cctcccgcaa ctgggcggct ttccgcggct gggccttcac gcgccttaag actaaggaaa    20880

ccccatcact gggctcgggc tacgaccctt attacaccta ctctggctct ataccctacc    20940

tagatggaac cttttacctc aaccacacct ttaagaaggt ggccattacc tttgactctt    21000

ctgtcagctg gcctggcaat gaccgcctgc ttacccccaa cgagtttgaa attaagcgct    21060

cagttgacgg ggagggttac aacgttgccc agtgtaacat gaccaaagac tggttcctgg    21120

tacaaatgct agctaactac aacattggct accagggctt ctatatccca gagagctaca    21180

aggaccgcat gtactccttc tttagaaact tccagcccat gagccgtcag gtggtggatg    21240

atactaaata caaggactac caacaggtgg gcatcctaca ccaacacaac aactctggat    21300

ttgttggcta ccttgccccc accatgcgcg aaggacaggc ctaccctgct aacttcccct    21360

atccgcttat aggcaagacc gcagttgaca gcattaccca gaaaaagttt ctttgcgatc    21420

gcaccctttg gcgcatccca ttctccagta actttatgtc catgggcgca ctcacagacc    21480

tgggccaaaa ccttctctac gccaactccg cccacgcgct agacatgact tttgaggtgg    21540

atcccatgga cgagcccacc cttctttatg ttttgtttga agtctttgac gtggtccgtg    21600

tgcaccggcc gcaccgcggc gtcatcgaaa ccgtgtacct gcgcacgccc ttctcggccg    21660

gcaacgccac aacataaaga agcaagcaac atcaacaaca gctgccgcca tgggctccag    21720

tgagcaggaa ctgaaagcca ttgtcaaaga tcttggttgt gggccatatt ttttgggcac    21780

ctatgacaag cgctttccag gctttgtttc tccacacaag ctcgcctgcg ccatagtcaa    21840

tacggccggt cgcgagactg ggggcgtaca ctggatggcc tttgcctgga acccgcactc    21900

aaaaacatgc tacctctttg agccctttgg cttttctgac cagcgactca agcaggttta    21960

ccagtttgag tacgagtcac tcctgcgccg tagcgccatt gcttcttccc ccgaccgctg    22020

tataacgctg gaaaagtcca cccaaagcgt acaggggccc aactcggccg cctgtggact    22080

attctgctgc atgtttctcc acgcctttgc caactggccc caaactccca tggatcacaa    22140

ccccaccatg aaccttatta ccggggtacc caactccatg ctcaacagtc cccaggtaca    22200

gcccaccctg cgtcgcaacc aggaacagct ctacagcttc ctggagcgcc actcgcccta    22260

cttccgcagc cacagtgcgc agattaggag cgccacttct ttttgtcact tgaaaaacat    22320

gtaaaaataa tgtactagag acactttcaa taaaggcaaa tgcttttatt tgtacactct    22380

cgggtgatta tttaccccca cccttgccgt ctgcgccgtt taaaaatcaa aggggttctg    22440

ccgcgcatcg ctatgcgcca ctggcaggga cacgttgcga tactggtgtt tagtgctcca    22500

cttaaactca ggcacaacca tccgcggcag ctcggtgaag ttttcactcc acaggctgcg    22560

caccatcacc aacgcgttta gcaggtcggg cgccgatatc ttgaagtcgc agttggggcc    22620

tccgccctgc gcgcgcgagt tgcgatacac agggttgcag cactggaaca ctatcagcgc    22680

cgggtggtgc acgctggcca gcacgctctt gtcggagatc agatccgcgt ccaggtcctc    22740

cgcgttgctc agggcgaacg gagtcaactt tggtagctgc cttcccaaaa agggcgcgtg    22800

cccaggcttt gagttgcact cgcaccgtag tggcatcaaa aggtgaccgt gcccggtctg    22860

ggcgttagga tacagcgcct gcataaaagc cttgatctgc ttaaaagcca cctgagcctt    22920

tgcgccttca gagaagaaca tgccgcaaga cttgccggaa aactgattgg ccggacaggc    22980

cgcgtcgtgc acgcagcacc ttgcgtcggt gttggagatc tgcaccacat ttcggcccca    23040

ccggttcttc acgatcttgg ccttgctaga ctgctccttc agcgcgcgct gcccgttttc    23100

gctcgtcaca tccatttcaa tcacgtgctc cttatttatc ataatgcttc cgtgtagaca    23160

cttaagctcg ccttcgatct cagcgcagcg gtgcagccac aacgcgcagc ccgtgggctc    23220

gtgatgcttg taggtcacct ctgcaaacga ctgcaggtac gcctgcagga atcgccccat    23280

catcgtcaca aaggtcttgt tgctggtgaa ggtcagctgc aacccgcggt gctcctcgtt    23340

cagccaggtc ttgcatacgg ccgccagagc ttccacttgg tcaggcagta gtttgaagtt    23400

cgcctttaga tcgttatcca cgtggtactt gtccatcagc gcgcgcgcag cctccatgcc    23460

cttctcccac gcagacacga tcggcacact cagcgggttc atcaccgtaa tttcactttc    23520

cgcttcgctg ggctcttcct cttcctcttg cgtccgcata ccacgcgcca ctgggtcgtc    23580

ttcattcagc cgccgcactg tgcgcttacc tcctttgcca tgcttgatta gcaccggtgg    23640

gttgctgaaa cccaccattt gtagcgccac atcttctctt tcttcctcgc tgtccacgat    23700

tacctctggt gatggcgggc gctcgggctt gggagaaggg cgcttctttt tcttcttggg    23760

cgcaatggcc aaatccgccg ccgaggtcga tggccgcggg ctgggtgtgc gcggcaccag    23820

cgcgtcttgt gatgagtctt cctcgtcctc ggactcgata cgccgcctca tccgcttttt    23880

tgggggcgcc cggggaggcg gcggcgacgg ggacggggac gacacgtcct ccatggttgg    23940

gggacgtcgc gccgcaccgc gtccgcgctc gggggtggtt tcgcgctgct cctcttcccg    24000

actggccatt tccttctcct ataggcagaa aaagatcatg gagtcagtcg agaagaagga    24060

cagcctaacc gccccctctg agttcgccac caccgcctcc accgatgccg ccaacgcgcc    24120

taccaccttc cccgtcgagg cacccccgct tgaggaggag gaagtgatta tcgagcagga    24180

cccaggtttt gtaagcgaag acgacgagga ccgctcagta ccaacagagg ataaaaagca    24240

agaccaggac aacgcagagg caaacgagga acaagtcggg cggggggacg aaaggcatgg    24300

cgactaccta gatgtgggag acgacgtgct gttgaagcat ctgcagcgcc agtgcgccat    24360

tatctgcgac gcgttgcaag agcgcagcga tgtgcccctc gccatagcgg atgtcagcct    24420

tgcctacgaa cgccacctat tctcaccgcg cgtacccccc aaacgccaag aaaacggcac    24480

atgcgagccc aacccgcgcc tcaacttcta ccccgtattt gccgtgccag aggtgcttgc    24540

cacctatcac atctttttcc aaaactgcaa gataccccta tcctgccgtg ccaaccgcag    24600

ccgagcggac aagcagctgg ccttgcggca gggcgctgtc atacctgata tcgcctcgct    24660

caacgaagtg ccaaaaatct ttgagggtct tggacgcgac gagaagcgcg cggcaaacgc    24720

tctgcaacag gaaaacagcg aaaatgaaag tcactctgga gtgttggtgg aactcgaggg    24780

tgacaacgcg cgcctagccg tactaaaacg cagcatcgag gtcacccact ttgcctaccc    24840

ggcacttaac ctacccccca aggtcatgag cacagtcatg agtgagctga tcgtgcgccg    24900

tgcgcagccc ctggagaggg atgcaaattt gcaagaacaa acagaggagg gcctacccgc    24960

agttggcgac gagcagctag cgcgctggct tcaaacgcgc gagcctgccg acttggagga    25020

gcgacgcaaa ctaatgatgg ccgcagtgct cgttaccgtg gagcttgagt gcatgcagcg    25080

gttctttgct gacccggaga tgcagcgcaa gctagaggaa acattgcact acacctttcg    25140

acagggctac gtacgccagg cctgcaagat ctccaacgtg gagctctgca acctggtctc    25200

ctaccttgga attttgcacg aaaaccgcct tgggcaaaac gtgcttcatt ccacgctcaa    25260

gggcgaggcg cgccgcgact acgtccgcga ctgcgtttac ttatttctat gctacacctg    25320

gcagacggcc atgggcgttt ggcagcagtg cttggaggag tgcaacctca aggagctgca    25380

gaaactgcta aagcaaaact tgaaggacct atggacggcc ttcaacgagc gctccgtggc    25440

cgcgcacctg gcggacatca ttttccccga acgcctgctt aaaaccctgc aacagggtct    25500

gccagacttc accagtcaaa gcatgttgca gaactttagg aactttatcc tagagcgctc    25560

aggaatcttg cccgccacct gctgtgcact tcctagcgac tttgtgccca ttaagtaccg    25620

cgaatgccct ccgccgcttt ggggccactg ctaccttctg cagctagcca actaccttgc    25680

ctaccactct gacataatgg aagacgtgag cggtgacggt ctactggagt gtcactgtcg    25740

ctgcaaccta tgcaccccgc accgctccct ggtttgcaat tcgcagctgc ttaacgaaag    25800

tcaaattatc ggtacctttg agctgcaggg tccctcgcct gacgaaaagt ccgcggctcc    25860

ggggttgaaa ctcactccgg ggctgtggac gtcggcttac cttcgcaaat ttgtacctga    25920

ggactaccac gcccacgaga ttaggttcta cgaagaccaa tcccgcccgc caaatgcgga    25980

gcttaccgcc tgcgtcatta cccagggcca cattcttggc caattgcaag ccatcaacaa    26040

agcccgccaa gagtttctgc tacgaaaggg acggggggtt tacttggacc cccagtccgg    26100

cgaggagctc aacccaatcc ccccgccgcc gcagccctat cagcagcagc cgcgggccct    26160

tgcttcccag gatggcaccc aaaaagaagc tgcagctgcc gccgccaccc acggacgagg    26220

aggaatactg ggacagtcag gcagaggagg ttttggacga ggaggaggag gacatgatgg    26280

aagactggga gagcctagac gaggaagctt ccgaggtcga agaggtgtca gacgaaacac    26340

cgtcaccctc ggtcgcattc ccctcgccgg cgccccagaa atcggcaacc ggttccagca    26400

tggctacaac ctccgctcct caggcgccgc cggcactgcc cgttcgccga cccaaccgta    26460

gatgggacac cactggaacc agggccggta agtccaagca gccgccgccg ttagcccaag    26520

agcaacaaca gcgccaaggc taccgctcat ggcgcgggca caagaacgcc atagttgctt    26580

gcttgcaaga ctgtgggggc aacatctcct tcgcccgccg ctttcttctc taccatcacg    26640

gcgtggcctt cccccgtaac atcctgcatt actaccgtca tctctacagc ccatactgca    26700

ccggcggcag cggcagcggc agcaacagca gcggccacac agaagcaaag gcgaccggat    26760

agcaagactc tgacaaagcc caagaaatcc acagcggcgg cagcagcagg aggaggagcg    26820

ctgcgtctgg cgcccaacga acccgtatcg acccgcgagc ttagaaacag gatttttccc    26880

actctgtatg ctatatttca acagagcagg ggccaagaac aagagctgaa aataaaaaac    26940

aggtctctgc gatccctcac ccgcagctgc ctgtatcaca aaagcgaaga tcagcttcgg    27000

cgcacgctgg aagacgcgga ggctctcttc agtaaatact gcgcgctgac tcttaaggac    27060

tagtttcgcg ccctttctca aatttaagcg cgaaaactac gtcatctcca gcggccacac    27120

ccggcgccag cacctgtcgt cagcgccatt atgagcaagg aaattcccac gccctacatg    27180

tggagttacc agccacaaat gggacttgcg gctggagctg cccaagacta ctcaacccga    27240

ataaactaca tgagcgcggg accccacatg atatcccggg tcaacggaat ccgcgcccac    27300

cgaaaccgaa ttctcttgga acaggcggct attaccacca cacctcgtaa taaccttaat    27360

ccccgtagtt ggcccgctgc cctggtgtac caggaaagtc ccgctcccac cactgtggta    27420

cttcccagag acgcccaggc cgaagttcag atgactaact caggggcgca gcttgcgggc    27480

ggctttcgtc acagggtgcg gtcgcccggg cagggtataa ctcacctgac aatcagaggg    27540

cgaggtattc agctcaacga cgagtcggtg agctcctcgc ttggtctccg tccggacggg    27600

acatttcaga tcggcggcgc cggccgctct tcattcacgc ctcgtcaggc aatcctaact    27660

ctgcagacct cgtcctctga gccgcgctct ggaggcattg gaactctgca atttattgag    27720

gagtttgtgc catcggtcta ctttaacccc ttctcgggac ctcccggcca ctatccggat    27780

caatttattc ctaactttga cgcggtaaag gactcggcgg atggctacga ctgaatgtta    27840

agtggagagg cagagcaact gcgcctgaaa cacctggtcc actgtcgccg ccacaagtgc    27900

tttgcccgcg actccggtga gttttgctac tttgaattgc ccgaggatca tatcgagggc    27960

ccggcgcacg gcgtccggct taccgcccag ggagagcttg cccgtagcct gattcgggag    28020

tttacccagc gccccctgct agttgagcgg gacaggggac cctgtgttct cactgtgatt    28080

tgcaactgtc ctaaccctgg attacatcaa gatctttgtt gccatctctg tgctgagtat    28140

aataaataca gaaattaaaa tatactgggg ctcctatcgc catcctgtaa acgccaccgt    28200

cttcacccgc ccaagcaaac caaggcgaac cttacctggt acttttaaca tctctccctc    28260

tgtgatttac aacagtttca acccagacgg agtgagtcta cgagagaacc tctccgagct    28320

cagctactcc atcagaaaaa acaccaccct ccttacctgc cgggaacgta cgacctaggg    28380

ataacagggt aataagcaat tgactctatg tgggatatgc tccagcgcta caaccttgaa    28440

gtcaggcttc ctggatgtca gcatctgact ttggccagca cctgtcccgc ggatttgttc    28500

cagtccaact acagcgaccc accctaacag agatgaccaa cacaaccaac gcggccgccg    28560

ctaccggact tacatctacc acaaatacac cccaagtttc tgcctttgtc aataactggg    28620

ataacttggg catgtggtgg ttctccatag cgcttatgtt tgtatgcctt attattatgt    28680

ggctcatctg ctgcctaaag cgcaaacgcg cccgaccacc catctatagt cccatcattg    28740

tgctacaccc aaacaatgat ggaatccata gattggacgg actgaaacac atgttctttt    28800

ctcttacagt atgattaaat gagacatgat tcctcgagtt tttatattac tgacccttgt    28860

tgcgcttttt tgtgcgtgct ccacattggc tgcggtttct cacatcgaag tagactgcat    28920

tccagccttc acagtctatt tgctttacgg atttgtcacc ctcacgctca tctgcagcct    28980

catcactgtg gtcatcgcct ttatccagtg cattgactgg gtctgtgtgc gctttgcata    29040

tctcagacac catccccagt acagggacag gactatagct gagcttctta gaattcttta    29100

attatgaaat ttactgtgac ttttctgctg attatttgca ccctatctgc gttttgttcc    29160

ccgacctcca agcctcaaag acatatatca tgcagattca ctcgtatatg gaatattcca    29220

agttgctaca atgaaaaaag cgatctttcc gaagcctggt tatatgcaat catctctgtt    29280

atggtgttct gcagtaccat cttagcccta gctatatatc cctaccttga cattggctgg    29340

aaacgaatag atgccatgaa ccacccaact ttccccgcgc ccgctatgct tccactgcaa    29400

caagttgttg ccggcggctt tgtcccagcc aatcagcctc gccccacttc tcccaccccc    29460

actgaaatca gctactttaa tctaacagga ggagatgact gacaccctag atctagaaat    29520

ggacggaatt attacagagc agcgcctgct agaaagacgc agggcagcgg ccgagcaaca    29580

gcgcatgaat caagagctcc aagacatggt taacttgcac cagtgcaaaa ggggtatctt    29640

ttgtctggta aagcaggcca aagtcaccta cgacagtaat accaccggac accgccttag    29700

ctacaagttg ccaaccaagc gtcagaaatt ggtggtcatg gtgggagaaa agcccattac    29760

cataactcag cactcggtag aaaccgaagg ctgcattcac tcaccttgtc aaggacctga    29820

ggatctctgc acccttatta agaccctgtg cggtctcaaa gatcttattc cctttaacta    29880

ataaaaaaaa ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt    29940

tattcagcag cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg    30000

caaactttct ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac    30060

ccactatctt catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc    30120

ccgtgtatcc atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct    30180

ttgtatcccc caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg    30240

aacctctagt tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg    30300

acgaggccgg caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa    30360

ccaagtcaaa cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa    30420

ctgtggctgc cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg    30480

ccccgctaac cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt    30540

cagaaggaaa gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc    30600

ttactatcac tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga    30660

aagagcccat ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg    30720

taacagacga cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata    30780

cttccttgca aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac    30840

ttaatgtagc aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta    30900

gttatccgtt tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta    30960

taaactcagc ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt    31020

caaacaattc caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg    31080

ctacagccat agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa    31140

acacaaatcc cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta    31200

tggttcctaa actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa    31260

acaaaaataa tgataagcta accctatgga caggtccaaa accagaagcc aactgcataa    31320

ttgaatacgg gaaacaaaac ccagatagca aactaacttt aatccttgta aaaaatggag    31380

gaattgttaa tggatatgta acgctaatgg gagcctcaga ctacgttaac accttattta    31440

aaaacaaaaa tgtctccatt aatgtagaac tatactttga tgccactggt catatattac    31500

cagactcatc ttctcttaaa acagatctag aactaaaata caagcaaacc gctgacttta    31560

gtgcaagagg ttttatgcca agtactacag cgtatccatt tgtccttcct aatgcgggaa    31620

cacataatga aaattatatt tttggtcaat gctactacaa agcaagcgat ggtgcccttt    31680

ttccgttgga agttactgtt atgcttaata aacgcctgcc agatagtcgc acatcctatg    31740

ttatgacttt tttatggtcc ttgaatgctg gtctagctcc agaaactact caggcaaccc    31800

tcataacctc cccatttacc ttttcctata ttagagaaga tgactaataa actctaaaga    31860

atcgtttgtg ttatgtttca acgtgtttat ttttcaattg cagaaaattt caagtcattt    31920

ttcattcagt agtatagccc caccaccaca tagcttatac agatcaccgt accttaatca    31980

aactcacaga accctagtat tcaacctgcc acctccctcc caacacacag agtacacagt    32040

cctttctccc cggctggcct taaaaagcat catatcatgg gtaacagaca tattcttagg    32100

tgttatattc cacacggttt cctgtcgagc caaacgctca tcagtgatat taataaactc    32160

cccgggcagc tcacttaagt tcatgtcgct gtccagctgc tgagccacag gctgctgtcc    32220

aacttgcggt tgcttaacgg gcggcgaagg agaagtccac gcctacatgg gggtagagtc    32280

ataatcgtgc atcaggatag ggcggtggtg ctgcagcagc gcgcgaataa actgctgccg    32340

ccgccgctcc gtcctgcagg aatacaacat ggcagtggtc tcctcagcga tgattcgcac    32400

cgcccgcagc ataaggcgcc ttgtcctccg ggcacagcag cgcaccctga tctcacttaa    32460

atcagcacag taactgcagc acagcaccac aatattgttc aaaatcccac agtgcaaggc    32520

gctgtatcca aagctcatgg cggggaccac agaacccacg tggccatcat accacaagcg    32580

caggtagatt aagtggcgac ccctcataaa cacgctggac ataaacatta cctcttttgg    32640

catgttgtaa ttcaccacct cccggtacca tataaacctc tgattaaaca tggcgccatc    32700

caccaccatc ctaaaccagc tggccaaaac ctgcccgccg gctatacact gcagggaacc    32760

gggactggaa caatgacagt ggagagccca ggactcgtaa ccatggatca tcatgctcgt    32820

catgatatca atgttggcac aacacaggca cacgtgcata cacttcctca ggattacaag    32880

ctcctcccgc gttagaacca tatcccaggg aacaacccat tcctgaatca gcgtaaatcc    32940

cacactgcag ggaagacctc gcacgtaact cacgttgtgc attgtcaaag tgttacattc    33000

gggcagcagc ggatgatcct ccagtatggt agcgcgggtt tctgtctcaa aaggaggtag    33060

acgatcccta ctgtacggag tgcgccgaga caaccgagat cgtgttggtc gtagtgtcat    33120

gccaaatgga acgccggacg tagtcatatt tcctgaagca aaaccaggtg cgggcgtgac    33180

aaacagatct gcgtctccgg tctcgccgct tagatcgctc tgtgtagtag ttgtagtata    33240

tccactctct caaagcatcc aggcgccccc tggcttcggg ttctatgtaa actccttcat    33300

gcgccgctgc cctgataaca tccaccaccg cagaataagc cacacccagc caacctacac    33360

attcgttctg cgagtcacac acgggaggag cgggaagagc tggaagaacc atgttttttt    33420

ttttattcca aaagattatc caaaacctca aaatgaagat ctattaagtg aacgcgctcc    33480

cctccggtgg cgtggtcaaa ctctacagcc aaagaacaga taatggcatt tgtaagatgt    33540

tgcacaatgg cttccaaaag gcaaacggcc ctcacgtcca agtggacgta aaggctaaac    33600

ccttcagggt gaatctcctc tataaacatt ccagcacctt caaccatgcc caaataattc    33660

tcatctcgcc accttctcaa tatatctcta agcaaatccc gaatattaag tccggccatt    33720

gtaaaaatct gctccagagc gccctccacc ttcagcctca agcagcgaat catgattgca    33780

aaaattcagg ttcctcacag acctgtataa gattcaaaag cggaacatta acaaaaatac    33840

cgcgatcccg taggtccctt cgcagggcca gctgaacata atcgtgcagg tctgcacgga    33900

ccagcgcggc cacttccccg ccaggaacct tgacaaaaga acccacactg attatgacac    33960

gcatactcgg agctatgcta accagcgtag ccccgatgta agctttgttg catgggcggc    34020

gatataaaat gcaaggtgct gctcaaaaaa tcaggcaaag cctcgcgcaa aaaagaaagc    34080

acatcgtagt catgctcatg cagataaagg caggtaagct ccggaaccac cacagaaaaa    34140

gacaccattt ttctctcaaa catgtctgcg ggtttctgca taaacacaaa ataaaataac    34200

aaaaaaacat ttaaacatta gaagcctgtc ttacaacagg aaaaacaacc cttataagca    34260

taagacggac tacggccatg ccggcgtgac cgtaaaaaaa ctggtcaccg tgattaaaaa    34320

gcaccaccga cagctcctcg gtcatgtccg gagtcataat gtaagactcg gtaaacacat    34380

caggttgatt catcggtcag tgctaaaaag cgaccgaaat agcccggggg aatacatacc    34440

cgcaggcgta gagacaacat tacagccccc ataggaggta taacaaaatt aataggagag    34500

aaaaacacat aaacacctga aaaaccctcc tgcctaggca aaatagcacc ctcccgctcc    34560

agaacaacat acagcgcttc acagcggcag cctaacagtc agccttacca gtaaaaaaga    34620

aaacctatta aaaaaacacc actcgacacg gcaccagctc aatcagtcac agtgtaaaaa    34680

agggccaagt gcagagcgag tatatatagg actaaaaaat gacgtaacgg ttaaagtcca    34740

caaaaaacac ccagaaaacc gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc    34800

acaacttcct caaatcgtca cttccgtttt cccacgttac gtaacttccc attttaagaa    34860

aactacaatt cccaacacat acaagttact ccgccctaaa acctacgtca cccgccccgt    34920

tcccacgccc cgcgccacgt cacaaactcc accccctcat tatcatattg gcttcaatcc    34980

aaaataaggt atattattga tgatgttaat                                     35010


<210>  56
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(A3)-CD28TM,ICD-CD3Z CAR

<400>  56

Met Thr Arg Ala Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly 
1               5                   10                  15      


Ala Ala Thr Gly Ala His Ser Glu Val Gln Leu Val Gln Ser Gly Thr 
            20                  25                  30          


Glu Val Lys Lys Pro Gly Ala Ser Val Arg Val Ser Cys Lys Ser Ser 
        35                  40                  45              


Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Met Ala Ile Ile Asn Pro Gly Asn Gly Asp 
65                  70                  75                  80  


Thr Asn Tyr Ala Gln Arg Phe Gln Gly Arg Val Thr Met Thr Arg Asp 
                85                  90                  95      


Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Ala Arg Glu Ile Ala Ser Tyr Ser Gly 
        115                 120                 125             


Ser Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ala Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly Thr 
                165                 170                 175     


Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Gly His 
            180                 185                 190         


Tyr Ala Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr Leu 
        195                 200                 205             


Phe Tyr Asn Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln 
225                 230                 235                 240 


Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Tyr Val Gly Asp Gly 
                245                 250                 255     


Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Glu Pro Lys 
            260                 265                 270         


Ser Cys Asp Lys Thr His Thr Cys Pro Thr Arg Phe Trp Val Leu Val 
        275                 280                 285             


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    290                 295                 300                 


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
305                 310                 315                 320 


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
                325                 330                 335     


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
            340                 345                 350         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        355                 360                 365             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    370                 375                 380                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
385                 390                 395                 400 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
                405                 410                 415     


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
            420                 425                 430         


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
        435                 440                 445             


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460                 


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(A3) LC-CDR1

<400>  57

Gly Leu Ser Ser Gly Ser Val Ser Thr Gly His Tyr Ala Ser 
1               5                   10                  


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(A3) LC-CDR2

<400>  58

Asn Thr Asn Thr Arg Ser Ser 
1               5           


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(A3) LC-CDR3

<400>  59

Val Leu Tyr Val Gly Asp Gly Ile Trp Val 
1               5                   10  


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(A3) HC-CDR1

<400>  60

Ser Tyr Tyr Ile His Trp Val Arg Gln Ala 
1               5                   10  


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(A3) HC-CDR2

<400>  61

Ile Ile Asn Pro Gly Asn Gly Asp Thr Asn Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(A3) HC-CDR3

<400>  62

Glu Ile Ala Ser Tyr Ser Gly Ser Tyr Tyr Asp Tyr 
1               5                   10          


<210>  63
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(A3) VL

<400>  63

Gln Ala Val Val Leu Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Gly 
            20                  25                  30          


His Tyr Ala Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Phe Tyr Asn Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Val Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Tyr Val Gly Asp 
                85                  90                  95      


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  64
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2(A3) VH

<400>  64

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Ile Ile Asn Pro Gly Asn Gly Asp Thr Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Ile Ala Ser Tyr Ser Gly Ser Tyr Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


