
                                SEQUENCE LISTING

<110> Rawlings, David J.
      Khan, Iram

<120> THERAPEUTIC GENOME EDITING IN WISKOTT-ALDRICH SYNDROME AND X-LINKED THROMBOCYTOPENIA
  

<130> SCRI.149WO

<150> 62/488249           
<151> 2017-04-21  

<160> 41

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2934
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of Full chemically modified guide #1

<400> 1
atggcgccgc ggcctcctaa gaagaagcgg aaagtcgaat tcgtggatct gcgaacactg 60
ggctatagcc agcagcagca ggagaagatc aaacccaagg tgaggtccac agtcgcacag 120
caccatgaag ccctggtggg ccacgggttc actcacgctc atattgtcgc actgtctcag 180
catccagccg ctctgggaac cgtggcagtc acataccagc acatcattac tgccctgccc 240
gaggctaccc atgaagacat cgtgggagtc ggcaaacagt ggagcggcgc acgggccctg 300
gaggctctgc tgaccgacgc aggggaactg agaggacccc ctctgcagct ggatacaggg 360
cagctggtga agattgctaa gaggggaggg gtgacagcaa tggaagccgt ccacgcaagc 420
aggaacgcac tgacaggggc ccccctgaac ctgaccccgg accaagtggt ggctatcgcc 480
agccacgatg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc 540
caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacgg tggcggcaag 600
caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc 660
ccggaccaag tggtggctat cgccagccac gatggcggca agcaagcgct cgaaacggtg 720
cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct 780
atcgccagcc acgatggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg 840
ctgtgccagg accatggcct gactccggac caagtggtgg ctatcgccag caacggtggc 900
ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc 960
ctgaccccgg accaagtggt ggctatcgcc agcaacattg gcggcaagca agcgctcgaa 1020
acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgactcc ggaccaagtg 1080
gtggctatcg ccagcaacaa tggcggcaag caagcgctcg aaacggtgca gcggctgttg 1140
ccggtgctgt gccaggacca tggcctgacc ccggaccaag tggtggctat cgccagcaac 1200
attggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac 1260
catggcctga ccccggacca agtggtggct atcgccagca acattggcgg caagcaagcg 1320
ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gactccggac 1380
caagtggtgg ctatcgccag caacggtggc ggcaagcaag cgctcgaaac ggtgcagcgg 1440
ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc 1500
agcaacggtg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc 1560
caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacgg tggcggcaag 1620
caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc 1680
ccggaccaag tggtggctat cgccagccac gatggcggca agcaagcgct cgaaacggtg 1740
cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct 1800
atcgccagcc acgatggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg 1860
ctgtgccagg accatggcct gaccccggac caagtggtgg ctatcgccag ccacgatggc 1920
ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc 1980
ctgactccgg accaagtggt ggctatcgcc agcaacaatg gcggcaagca agcgctcgaa 2040
acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgacccc ggaccaagtg 2100
gtggctatcg ccagcaacgg tggcggcaag caagcgctcg aaagcattgt ggcccagctg 2160
agccggcctg atccggcgtt ggccgcgttg accaacgacc acctggtcgc tctggcttgc 2220
ctgggaggac gccctgctat ggacgctgtg aagaaaggac tgccccacgc acccgaactg 2280
attagacggg tgaaccggag aatcggcgag agaacatccc atagggtggc aatctctaga 2340
actcagctgg tcaagagtga actggaggaa aagaaatcag agctgcgcca caagctgaaa 2400
tacgtgcctc atgagtatat cgaactgatc gagattgctc gcaattcaac ccaggaccgg 2460
atcctggaaa tgaaagtgat ggagttcttt atgaaagtct acggatatcg ggggaaacac 2520
ctgggaggga gcagaaagcc agatggggcc atctacacag tgggatcccc catcgactat 2580
ggcgtgattg tcgatactaa agcctacagc ggaggctata acctgcctat cggccaggct 2640
gacgagatgc agagatacgt ggaggaaaac cagacccgca ataagcatat taaccccaat 2700
gaatggtgga aagtgtatcc tagctccgtc acagagttca agtttctgtt cgtgagcgga 2760
cactttaagg gcaactacaa agcacagctg actaggctga atcatatcac caactgcaat 2820
ggagccgtgc tgtctgtcga ggaactgctg atcgggggag agatgattaa ggctggcaca 2880
ctgactctgg aggaagtgag gcgcaagttc aacaatgggg aaatcaactt ctaa       2934

<210> 2
<211> 3036
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of Full chemically modified guide #1

<400> 2
atggcgccgc ggcctcctaa gaagaagcgg aaagtcgaat tcgtggatct gcgaacactg 60
ggctatagcc agcagcagca ggagaagatc aaacccaagg tgaggtccac agtcgcacag 120
caccatgaag ccctggtggg ccacgggttc actcacgctc atattgtcgc actgtctcag 180
catccagccg ctctgggaac cgtggcagtc acataccagc acatcattac tgccctgccc 240
gaggctaccc atgaagacat cgtgggagtc ggcaaacagt ggagcggcgc acgggccctg 300
gaggctctgc tgaccgacgc aggggaactg agaggacccc ctctgcagct ggatacaggg 360
cagctggtga agattgctaa gaggggaggg gtgacagcaa tggaagccgt ccacgcaagc 420
aggaacgcac tgacaggggc ccccctgaac ctgaccccgg accaagtggt ggctatcgcc 480
agcaacattg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc 540
caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacaa tggcggcaag 600
caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc 660
ccggaccaag tggtggctat cgccagcaac attggcggca agcaagcgct cgaaacggtg 720
cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct 780
atcgccagcc acgatggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg 840
ctgtgccagg accatggcct gactccggac caagtggtgg ctatcgccag caacattggc 900
ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc 960
ctgaccccgg accaagtggt ggctatcgcc agcaacggtg gcggcaagca agcgctcgaa 1020
acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgactcc ggaccaagtg 1080
gtggctatcg ccagcaacgg tggcggcaag caagcgctcg aaacggtgca gcggctgttg 1140
ccggtgctgt gccaggacca tggcctgacc ccggaccaag tggtggctat cgccagcaac 1200
aatggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac 1260
catggcctga ccccggacca agtggtggct atcgccagca acattggcgg caagcaagcg 1320
ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gactccggac 1380
caagtggtgg ctatcgccag caacaatggc ggcaagcaag cgctcgaaac ggtgcagcgg 1440
ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc 1500
agcaacattg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc 1560
caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacgg tggcggcaag 1620
caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc 1680
ccggaccaag tggtggctat cgccagccac gatggcggca agcaagcgct cgaaacggtg 1740
cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct 1800
atcgccagca acggtggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg 1860
ctgtgccagg accatggcct gaccccggac caagtggtgg ctatcgccag caacggtggc 1920
ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc 1980
ctgactccgg accaagtggt ggctatcgcc agccacgatg gcggcaagca agcgctcgaa 2040
acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgacccc ggaccaagtg 2100
gtggctatcg ccagccacga tggcggcaag caagcgctcg aaacggtgca gcggctgttg 2160
ccggtgctgt gccaggacca tggcctgacc ccggaccaag tggtggctat cgccagcaac 2220
ggtggcggca agcaagcgct cgaaagcatt gtggcccagc tgagccggcc tgatccggcg 2280
ttggccgcgt tgaccaacga ccacctggtc gctctggctt gcctgggagg acgccctgct 2340
atggacgctg tgaagaaagg actgccccac gcacccgaac tgattagacg ggtgaaccgg 2400
agaatcggcg agagaacatc ccatagggtg gcaatctcta gaactcagct ggtcaagagt 2460
gaactggagg aaaagaaatc agagctgcgc cacaagctga aatacgtgcc tcatgagtat 2520
atcgaactga tcgagattgc tcgcaattca acccaggacc ggatcctgga aatgaaagtg 2580
atggagttct ttatgaaagt ctacggatat cgggggaaac acctgggagg gagcagaaag 2640
ccagatgggg ccatctacac agtgggatcc cccatcgact atggcgtgat tgtcgatact 2700
aaagcctaca gcggaggcta taacctgcct atcggccagg ctgacgagat gcagagatac 2760
gtggaggaaa accagacccg caataagcat attaacccca atgaatggtg gaaagtgtat 2820
cctagctccg tcacagagtt caagtttctg ttcgtgagcg gacactttaa gggcaactac 2880
aaagcacagc tgactaggct gaatcatatc accaactgca atggagccgt gctgtctgtc 2940
gaggaactgc tgatcggggg agagatgatt aaggctggca cactgactct ggaggaagtg 3000
aggcgcaagt tcaacaatgg ggaaatcaac ttctaa                           3036

<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of Full chemically modified guide #1

<400> 3
ggtatgttct gctgaaccgc                                             20

<210> 4
<211> 9634
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of Full chemically modified guide #1

<400> 4
agcagaaggg gttctgaacc taggttcagg agagaggctt tgaacctgca cgtgtgggaa 60
gccatggaag tttccaggaa ggactgcagg tcccaactgg agatgtgccg ttcctccttc 120
aggtacctgg gaatgtcagt cacaccccag acctgctcag ctcccccaaa ctgctgttcc 180
tgtatctgag agcttcaagt ctccaaatgg cctacctcat acatggggaa actgaggcct 240
ggggaggccg gggactgagc tagcattcac ttgtggaaat agtctggcat catctggaga 300
agttagagac atgcaaaccc tacagccctc agattcccgt ctgagagtct gcatgcctat 360
gtggaccagg agatgtgtgc gggagtgaac actgcagtgt tgctcccaac agcaagaacc 420
agaagcagcc caaagggctg ttacaggaga atatggacac ccaggctgca catgcacacc 480
atggaatgct gtatggcagt ggaaataaat gaacagctac cactataggc aaacaggaat 540
cacagcaaca gccaagagtg aaggcgtgga gggacgagac catgcactca cacctggcct 600
gcctggctcg cactccgggc aaaggggtca gaacagtgac tggcacacac gttaagtgct 660
atgtgagtgt taagataaaa ctaggatgtc cagtggggag aaagcaagcc tttgaagatt 720
atgtgctttt acaaacttca agtgcaatga aaactaaaca agatgttgtt caggcattca 780
tatatgatat aaagttcctt tctttaaaaa agggatgggc tgggcacggt ggctcacgcc 840
tgtaattcta atactttggg aggccgaggc aggtggatca cgaggtcgag aaatcgagac 900
catcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaaaa ttagctgggc 960
gtggtggcgt gtgcctgtag tcccagctac ttgggaggct gaggcaggag agtcacttga 1020
acccgggagg caaaggttgc agtgagccga gatcgtgcca ccgcactcca gcctggcgac 1080
agagtgagac tccatctcaa aaaaaaaaag aaaaaaaaaa gtatgacaag cagaaagtaa 1140
tttgggagct gcggggaggc aagggtaagg gatggggaag tggaccagag gcatatgcgt 1200
cattggcagt gtctaagcac tcacgatagg cgtggatcac aggggctcgc tctgtaatta 1260
aaaggaaaag ggtttttgtt gtgttgttgt tgttgctgtt tttgagacaa gggtcttgct 1320
ctgtcatcat ccaggctgga gtgcagtggt gcagtctcag ctcactgcaa cctccgcctc 1380
ctgggttcaa gcgattctcc tgcctcagcc tcctgagcag ctaggactac aggtgtgtgc 1440
caccatgcct ggctaatttt tgtatttttt agtggaaatg gggttttgcc atgttgccca 1500
ggctcgtctt gaactcctga cctcaagtga tccactcgtc tcggcctccc aaagtgctgg 1560
gattacaggt gtgagctatt gtccccagcc aaaaggaaaa gttttactgt agtaaccctt 1620
ccggactagg gacctcgggc ctcagcctca ggctacctag gtgctttaga aaggaggcca 1680
cccaggccca tgactactcc ttgccacagg gagccctgca cacagatgtg ctaagctctc 1740
gctgccagcc agagggagga gggtctgagc cagtcagaag gagatgggcc ccagagagta 1800
agaaaggggg aggaggaccc aagctgatcc aaaaggtggg tctaagcagt caagtggagg 1860
agggttccaa tctgatggcg gagggcccaa gctcagccta acgaggaggc caggcccacc 1920
aaggggcccc tggaggactt gtttcccttg tcccttgtgg ttttttgcat ttcctgttcc 1980
cttgctgctc attgcggaag ttcctcttct taccctgcac ccagagcctc gccagagaag 2040
acaagggcag aaagcaccat gagtgggggc ccaatgggag gaaggcccgg gggccgagga 2100
gcaccagcgg ttcagcagaa cataccctcc accctcctcc aggaccacga gaaccagcga 2160
ctctttgaga tgcttggacg aaaatgcttg gtgagctggg gatctcctgc ccccgccccg 2220
tccccaccgt ttcttcctct tcctctcctc cttctctctc ttcccctcct cccgctcctc 2280
ctttccctct ccatcatctc ctctcctaga atttcccgtc ataatccacc cttcccagga 2340
agatctcaat gtctacttgc cttccctctg gctgcagctc ttcctttggg cccatgactg 2400
tcatgaggca ggaaggacca ggtctggctc caagaccttg tggctacccc tgaccagact 2460
ccactgaccc ctgctttcct ctcccagacg ctggccactg cagttgttca gctgtacctg 2520
gcgctgcccc ctggagctga gcactggacc aaggagcatt gtggggctgt gtgcttcgtg 2580
aaggataacc cccagaagtc ctacttcatc cgcctttacg gccttcaggt gaccccccca 2640
cccccgactg gacttgcaag ccagttctca acccgcaaac ccagatctgt gtccatatgt 2700
gtccatagct tcaagacctc agacctgatc agtgaatccc tgagccccag aaccaaagac 2760
tcatccagat ggcaaactct gacttgcctt tctaagtctg caatgactgg ccccagtctc 2820
cgtatcaaga tctctaaagc ccccagtatt agtctgctgc ctaagcctaa tcttttccac 2880
aaattccaat aaatgagcac tgtatttgta cctgaacctc aaatctattc taaactcaac 2940
attttgcatc ccaggaatct ctcatcaaaa ctcctgaacc ccagatgttt gccaagctcc 3000
taagtcataa atctgttcaa caaaccccaa agttgaatat tccattgatc cttgaactcc 3060
aaatctgtcc ttctaaatcc acagcacaga ccccagagtt cccatattaa aattcctgaa 3120
cactcaaata ccgaggtagt tcttaagcaa aaagtctttt ccacaatccc ctgacctgaa 3180
ctttctaggt ttaagcccca aattcatcct tttaaaccca taaagatgga cccagcataa 3240
cttccagatc ccaaggctat caaatatcca ccaaactcct aaaccataac tctctccaca 3300
aaccccaaat tgcacttact ttagctggac tccccgcgaa actcccaagt ctatgtgtct 3360
gaacttcaaa tctcaactcc aacccccaaa tactagaatc ctacctgtca tgaattgggg 3420
ctggggtggt gggggagggc atggattgaa tctgtgaatg agcctcaact tcctaagact 3480
agagtcctaa attatgaaat tcaagccccc aagtcccaga tctagggccc caaaccccaa 3540
atccaaacct ctcacaaaag tgtatggctc ccagactata ccccacaatc cacaccctta 3600
gacaccaact ctctggtgct gagctgaaaa tctccaaacc agactatgag gctcccaaat 3660
ccagacaccc tgctccctgc ccagctaaca aaagcctgcc acccccggcg tgcctcagtg 3720
ccactgtgcc tcccacccta cacctctcca ggctggtcgg ctgctctggg aacaggagct 3780
gtactcacag cttgtctact ccacccccac ccccttcttc cacaccttcg ctggagatgt 3840
aagtgatcaa ccagccctcg ggcctcactt ggggtgtgga gaggagatgg gaaagttgcg 3900
ggggacctgg gaggcggctg accccaaggt atgtgcagga ctgccaagcg gggctgaact 3960
ttgcagacga ggacgaggcc caggccttcc gggccctcgt gcaggagaag atacaaaaaa 4020
ggaatcagag gcaaagtgga ggtgaggagg ccacagggga ggaaaggaag ttgggcagag 4080
gtgagtgcaa gcctggggaa ctagaaaagt cccctctcat ggtcctggct cccaatccat 4140
ctatccacag acagacgcca gctaccccca ccaccaacac cagccaatga aggtgagtcc 4200
tctagtgcaa gtaggggtaa taaggggcta gcccaggaac ctgtggcagg gctgtgataa 4260
ctctctacac attccatctt cccagagaga agaggagggc tcccacccct gcccctgcat 4320
ccaggtggag accaaggagg tgcgtgctga ttcttccctg tgtctctgga tggatgggta 4380
agagtggatg gaggaatgag gagttggatg ggtgcgtaag tgggtgaatg gataggtaga 4440
ttgataggta tgtggatgga cgagcaggtg catggatgtg tggactgatg gatgggtgga 4500
tggattggcg gtagatggct gagtagaggg atgaattgat gggaggatga aagtctaagt 4560
agatagatgc ataggtgaat gggtatgtgg ataaatgaat gaaaaggtag atggatgact 4620
gagtaaatta atcaatgagt gaatgaatga acagtgaata aatgactaaa tgacaagttt 4680
cagtcagtga agaaagcatg attgaatgaa taaatgagta aatgaatatt ttaacaaatt 4740
cattagtcaa tgagccagtg aatgataaag catgagggaa tgaaaacatg aatgaatcag 4800
tgaatgtatg aatggtttgt gggatccacc cacttctcca tagaccctac ttgaaccctt 4860
cacccactac ctccatgacc atccaacaca cacacagatt tccctcaagg cttccgtttc 4920
ttgcccctgt gctttggttg gttggtaagt gggtcaatga gccaaccacc ctattttccc 4980
cacaggccct ccagtgggtc cgctctccct ggggctggcg acagtggaca tccagaaccc 5040
tgacatcacg agttcacgat accgtgggct cccagcacct ggacctagcc cagctgataa 5100
gaaacgctca gggaagaaga agatcagcaa agctgatatt ggtgcaccca gtggattcaa 5160
gtgagagcca ctccccagtg gacccacaga ttcctggggg cagaggggca catgaacaag 5220
tggacagctg agtgaatgga aggatgggca gatgggcaga tggctgggtg gctgagtggg 5280
taaatgggtg gttggatagg taggtgcagg gctgggtcta gggagaggta aataaggcac 5340
caagggtaca aaatttaagg aggcactcac tctcagaggc atgcaactgt aattcctgac 5400
tctcagagtg agtgactcac ttaaattttg caccctaggc accttacttg cctcaccctg 5460
ggcccactct gggtgggctg ttaggagagc aggtgggtgg gcaggtgaac aaatggatag 5520
atagatgagg tagatgatgg atgagaaggg ctggtgggta ggtgggtgag tggatgggtg 5580
gatggatgga taaatgaatg gatgaatgaa tgggttgaag aatgaatgga taagtggttg 5640
gatggacaag tttatgggtg gatgggttga tgggaggtgc gtggatagat agatgggtga 5700
gtggataggt gtgtggacag attgatatgc aggctgattg gctcacagac aaggtggatg 5760
gggatggaca ggtggacaga tacgtggatg aatggacagt tcaatggata agtgaacaga 5820
agtgtgtggt tgcatgggta gaaaaatgag tggatggata gatggaaagg tgggcacatg 5880
ggtaggtgga tgggtggatg gacaagtgtg tgtgaggaca gactggtgga caaatgggtg 5940
aacagacata tgtgggcaga tagttgcaga gacagatgta tggacagatc agtagtccaa 6000
cagatgaatg tgaatgaata ggtggacaaa tgcatgggat agatggggaa agagggatgg 6060
gtggatggat cagcaccaca aactatggag cccttctaat tccataactc ctgcctatac 6120
tcattcactc attcagtctc attcattaat tctggcccct cagagtctct ttgggcagga 6180
gagggcaaga gggtttcact atgaagggag ggaaggaagg gcagtgagga ttcactggag 6240
tctcttcacc tctcccaggc atgtcagcca cgtggggtgg gacccccaga atggatttga 6300
cgtgagtaac ttcagagtct cttggactcc actaaacttc cacccaccct tccaaagacc 6360
actgctgaga ccccaccccc agatcgtgcc cttcccacac ccctctcaga tcccttgctg 6420
ggatggaccc aacgacaatc catgtcgctt gtctcctcgc cttattcctc tactcctgcc 6480
cctggccttt ttcctcctgg gcaggtgaac aacctcgacc cagatctgcg gagtctgttc 6540
tccagggcag gaatcagcga ggcccagctc accgacgccg agacctctaa acttatctac 6600
gacttcattg aggaccaggg tgggctggag gctgtgcggc aggagatgag gcgccagggt 6660
gagaccctgc ttccatacgc tcccttctct agcccaagca gctcatagct aagatacgca 6720
ctaagtcact cagtccttat gggagcacct atactgcttc agtcaggagt tggtcagtgg 6780
gggtacccat tttacaaatg agcaaaactg aggctcagaa gaaatcaatg agagttacag 6840
ctatgtgtta taccccctcc acagagccac ttccgccgcc cccaccgcca tctcgaggag 6900
ggaaccagct cccccggccc cctattgtgg ggggtaacaa gggtcgttct ggtccactgc 6960
cccctgtacc tttggggatt gccccacccc caccaacacc ccggggaccc ccacccccag 7020
gccgaggggg ccctccacca ccaccccctc cagctactgg acgttctgga ccactgcccc 7080
ctccaccccc tggagctggt gggccaccca tgccaccacc accgccacca ccgccaccgc 7140
cgcccagctc cgggaatgga ccagcccctc ccccactccc tcctgctctg gtgcctgccg 7200
ggggcctggc ccctggtggg ggtcggggag cgcttttgga tcaaatccgg cagggaattc 7260
agctgaacaa ggtgaggaca ggcaggatgg aggattgggg gtctaggact ctggggtgtc 7320
ccgtctaagt caggatactg gggggctgag gccaggactg aggagagtgc caggccttag 7380
ggattcagtg atagggttga aaggttggtg ggaagccttg aaggggactg gagtgtgtgg 7440
gagagaaaat attgatggag gggcggggag aaatgctcct ttcccaggcc ctaagccctc 7500
tgtgctgatc cctgcctgct gcagacccct ggggccccag agagctcagc gctgcagcca 7560
ccacctcaga gctcagaggg actggtgggg gccctgatgc acgtgatgca gaagagaagc 7620
agagccatcc actcctccgg tgagctgatc ctgccggggc ctcaaacctg gctcccaggg 7680
ctagcactgg cctcaaaaca atcccagcag tcaccaccaa tagtgacatc agccccatct 7740
gtttgacagc attaacatga atcttgtgtc agcctcgttt ttgacaatgt taacattaag 7800
tcattatgtg acaataatat aattaactcc aactttgaca gtaatattaa cattaatgcc 7860
agggtgtgtc cacaatatta atgtcattcc cacatgttca gtactactaa catcagctgg 7920
ccgggcgcgg tggctcatgc ctgtaatcca ggaactttgg gaggctaagg caggaggatc 7980
acttgagccc aggagttcga gaccagcctg ggcaatatag tgagacctcg tttccataaa 8040
aactaaattc aaaaaaagta gtcaagcata gtggtgtgtg cctgtggtcc cagctacttg 8100
ggaggctgag gtgggaggat tgcttgaccc tgggaggtca aggcagcagt gatccatgat 8160
tgtgccactg cactccagcc tgggtgacag agatcctatc tcaaaaaaaa aaaaaattaa 8220
cccattatgt gatgacaata ttatgaagaa cactattgtt gacaatatta attttaattc 8280
catgtattaa cagatttaca ttaattcatt atgacgtaac ctaatctaat cttttaaaaa 8340
atttttttga aacagggtct cgctctgtgt cccaggctgg agtacagtgg tgcaatcatg 8400
gctcagtgca gcctcaacct cccaggctca agcgatcctc ccgcctcagc tcccaaagta 8460
gctgggacta caggcgtgtg ccaccatacc tggctaattt ttggtgtttt tttggtagtg 8520
atgagctctc actaccaagc tctcactact ctcatgttgc ccaggctgct ctgcaactcc 8580
agggctcaag cgatctgccc cgcctcagcc tcccagagtg ctgggattac aggcatgagc 8640
caccaggcct ggctgttaac ctaatctttt tataataatg ttactattac tctcttaatc 8700
tgtcagcaat actgtcacta atccattata tgatgcaaat attagtatca acctactata 8760
ggaacttcat ctttcgacaa tgattttttt ttttcttttg agacggagtc ttgctctgtc 8820
acccaggctg gagtgcagtg gcgcgatctt ggctaactgc agactctgcc tcctgggttc 8880
aagcgattct cctgcctcag ccttccgagt agctgggact acaggcacgc cactacgccc 8940
agctaatttt gatgttattg tcattaaccc cattatgtgt caaaaatatt agcgttaacc 9000
agacaggaag caataatata ttatcacacc tttgctaata ttatttaaat tcaccctatt 9060
atgtgataaa taggttaaca ttaacccttt gtttgacaat atctcgacta accacatttt 9120
tgacagcata aacttcaact ccaactagaa ctcagacccc aactataatc cctttcttgt 9180
cccaaatgga aactctaact tgccctcctc tagcatgaga cctcagaacc ccagggtcca 9240
gtcctcacct cccaggccct atgaagcccc ccaccaacct cccagggcat cttatctttc 9300
tctttccctc cagacgaagg ggaggaccag gctggcgatg aagatgaaga tgatgaatgg 9360
gatgactgag tggctgagtt acttgctgcc ctgtgctcct ccccgcagga catggctccc 9420
cctccacctg ctctgtgccc accctccact ctcctcttcc aggcccccaa ccccccattt 9480
cttccccacc aacccctcca atgctgttat ccctgcctgg tcctcacact cacccaacaa 9540
tcccaaggcc ctttttatac aaaaattctc agttctcttc actcaaggat ttttaaagaa 9600
aaataaaaga attgtctttc tgtctctcta taaa                             9634



<210> 5
<211> 7264
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of Full chemically modified guide #1

<400> 5
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tgtatgacaa gcagaaagta atttgggagc tgcggggagg caagggtaag ggatggggaa 300
gtggaccaga ggcatatgcg tcattggcag tgtctaagca ctcacgatag gcgtggatca 360
caggggctcg ctctgtaatt aaaaggaaaa gggtttttgt tgtgttgttg ttgttgctgt 420
ttttgagaca agggtcttgc tctgtcatca tccaggctgg agtgcagtgg tgcagtctca 480
gctcactgca acctccgcct cctgggttca agcgattctc ctgcctcagc ctcctgagca 540
gctaggacta caggtgtgtg ccaccatgcc tggctaattt ttgtattttt tagtggaaat 600
ggggttttgc catgttgccc aggctcgtct tgaactcctg acctcaagtg atccactcgt 660
ctcggcctcc caaagtgctg ggattacagg tgtgagctat tgtccccagc caaaaggaaa 720
agttttactg tagtaaccct tccggactag ggacctcggg cctcagcctc aggctaccta 780
ggtgctttag aaaggaggcc acccaggccc atgactactc cttgccacag ggagccctgc 840
acacagatgt gctaagctct cgctgccagc cagagggagg agggtctgag ccagtcagaa 900
ggagatgggc cccagagagt aagaaagggg gaggaggacc caagctgatc caaaaggtgg 960
gtctaagcag tcaagtggag gagggttcca atctgatggc ggagggccca agctcagcct 1020
aacgaggagg ccaggcccac caaggggccc ctggaggact tgtttccctt gtcccttgtg 1080
gttttttgca tttcctgttc ccttgctgct cattgcggaa gttcctcttc ttaccctgca 1140
cccagagcct cgccagagaa gacaagggca gaaagcacca tgagtggggg cccaatggga 1200
ggaaggcccg ggggccgagg agcacgaaca gagaaacagg agaatatggg ccaaacagga 1260
tatctgtggt aagcagttcc tgccccggct cagggccaag aacagttgga acagcagaat 1320
atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag 1380
atggtcccca gatgcggtcc cgccctcagc agtttctaga gaaccatcag atgtttccag 1440
ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga actaaccaat cagttcgctt 1500
ctcgcttctg ttcgcgcgct tctgctcccc gagctctata taagcagagc tcgtttagtg 1560
aaccgtcaga tcgcctggag acgccatcca cgctgttttg acttccatag aaggatctcg 1620
aggccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg 1680
agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg 1740
ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct 1800
ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc 1860
acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca 1920
ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg 1980
acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc 2040
tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc 2100
agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc 2160
agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg 2220
acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc 2280
acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt 2340
acaagtaaac tagtgtcgac tgctttattt gtgaaatttg tgatgctatt gctttatttg 2400
taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc 2460
aggttcaggg ggaggtgtgg gaggtttttt aaacagcggt tcagcagaac ataccctcca 2520
ccctcctcca ggaccacgag aaccagcgac tctttgagat gcttggacga aaatgcttgg 2580
tgagctgggg atctcctgcc cccgccccgt ccccaccgtt tcttcctctt cctctcctcc 2640
ttctctctct tcccctcctc ccgctcctcc tttccctctc catcatctcc tctcctagaa 2700
tttcccgtca taatccaccc ttcccaggaa gatctcaatg tctacttgcc ttccctctgg 2760
ctgcagctct tcctttgggc ccatgactgt catgaggcag gaaggaccag gtctggctcc 2820
aagaccttgt ggctacccct gaccagactc cactgacccc tgctttcctc tcccagacgc 2880
tggccactgc agttgttcag ctgtacctgg cgctgccccc tggagctgag cactggacca 2940
aggagcattg tggggctgtg tgcttcgtga aggataaccc ccagaagtcc tacttcatcc 3000
gcctttacgg ccttcaggtg acccccccac ccccgactgg acttgcaagc cagttctcaa 3060
cccgcaaacc cagatctgtg tccatatgtg tccatagctt caagacctca gacctgatca 3120
gtgaatccct gagccccaga accaaagact catccagatg gcaaactctg acttgccttt 3180
ctaagtctgc aatgactggc cccagtctcc gtatcaagat ctctaaagcc cccagtatta 3240
gtctgctgcc taagcctaat cttttccaca aattccaata aatgagcact gtatttgtac 3300
ctgaacctca aatctattct aaactcaaca ttttgcatcc caggaatctc tcatcaaaac 3360
tcctgaaccc cagatgtttg ccaagctcct aagtcataaa tctgttcaac aaaccccaaa 3420
gttgaatatt ccattgatcc ttgaactcca aatctgtcct tctaaatcca cagcacagac 3480
cccagagttc ccatctagag catggctacg tagataagta gcatggcggg ttaatcatta 3540
actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca 3600
ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga 3660
gcgagcgagc gcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa 3720
cagttgcgca gcctgaatgg cgaatggcga ttccgttgca atggctggcg gtaatattgt 3780
tctggatatt accagcaagg ccgatagttt gagttcttct actcaggcaa gtgatgttat 3840
tactaatcaa agaagtattg cgacaacggt taatttgcgt gatggacaga ctcttttact 3900
cggtggcctc actgattata aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa 3960
aatcccttta atcggcctcc tgtttagctc ccgctctgat tctaacgagg aaagcacgtt 4020
atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg 4080
gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt 4140
tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc 4200
gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg 4260
attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga 4320
cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc 4380
ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa 4440
aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa 4500
tttaaatatt tgcttataca atcttcctgt ttttggggct tttctgatta tcaaccgggg 4560
tacatatgat tgacatgcta gttttacgat taccgttcat cgattctctt gtttgctcca 4620
gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc 4680
cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc 4740
cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat 4800
atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt 4860
attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt 4920
gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg 4980
atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc 5040
agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct 5100
gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc 5160
tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag 5220
ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg 5280
tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata 5340
cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga 5400
aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca 5460
ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat 5520
cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag 5580
agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc 5640
gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct 5700
cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca 5760
gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt 5820
ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat 5880
gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt 5940
gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta 6000
cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga 6060
ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt 6120
gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc 6180
gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct 6240
gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata 6300
ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt 6360
gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc 6420
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg 6480
caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact 6540
ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg 6600
tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg 6660
ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac 6720
tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca 6780
cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga 6840
gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc 6900
ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct 6960
gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg 7020
agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct 7080
tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc 7140
tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc 7200
gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg ccgattcatt 7260
aatg                                                              7264



<210> 6
<211> 7265
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of Full chemically modified guide #1

<400> 6
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tgtatgacaa gcagaaagta atttgggagc tgcggggagg caagggtaag ggatggggaa 300
gtggaccaga ggcatatgcg tcattggcag tgtctaagca ctcacgatag gcgtggatca 360
caggggctcg ctctgtaatt aaaaggaaaa gggtttttgt tgtgttgttg ttgttgctgt 420
ttttgagaca agggtcttgc tctgtcatca tccaggctgg agtgcagtgg tgcagtctca 480
gctcactgca acctccgcct cctgggttca agcgattctc ctgcctcagc ctcctgagca 540
gctaggacta caggtgtgtg ccaccatgcc tggctaattt ttgtattttt tagtggaaat 600
ggggttttgc catgttgccc aggctcgtct tgaactcctg acctcaagtg atccactcgt 660
ctcggcctcc caaagtgctg ggattacagg tgtgagctat tgtccccagc caaaaggaaa 720
agttttactg tagtaaccct tccggactag ggacctcggg cctcagcctc aggctaccta 780
ggtgctttag aaaggaggcc acccaggccc atgactactc cttgccacag ggagccctgc 840
acacagatgt gctaagctct cgctgccagc cagagggagg agggtctgag ccagtcagaa 900
ggagatgggc cccagagagt aagaaagggg gaggaggacc caagctgatc caaaaggtgg 960
gtctaagcag tcaagtggag gagggttcca atctgatggc ggagggccca agctcagcct 1020
aacgaggagg ccaggcccac caaggggccc ctggaggact tgtttccctt gtcccttgtg 1080
gttttttgca tttcctgttc ccttgctgct cattgcggaa gttcctcttc ttaccctgca 1140
cccagagcct cgccagagaa gacaagggca gaaagcacca tgagtggggg cccaatggga 1200
ggaaggcccg ggggccgagg agcacgaaca gagaaacagg agaatatggg ccaaacagga 1260
tatctgtggt aagcagttcc tgccccggct cagggccaag aacagttgga acagcagaat 1320
atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag 1380
atggtcccca gatgcggtcc cgccctcagc agtttctaga gaaccatcag atgtttccag 1440
ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga actaaccaat cagttcgctt 1500
ctcgcttctg ttcgcgcgct tctgctcccc gagctctata taagcagagc tcgtttagtg 1560
aaccgtcaga tcgcctggag acgccatcca cgctgttttg acttccatag aaggatctcg 1620
aggccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg 1680
agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg 1740
ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct 1800
ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc 1860
acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca 1920
ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg 1980
acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc 2040
tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc 2100
agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc 2160
agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg 2220
acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc 2280
acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt 2340
acaagtaaac tagtgtcgac tgctttattt gtgaaatttg tgatgctatt gctttatttg 2400
taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc 2460
aggttcaggg ggaggtgtgg gaggtttttt aaacagcggt tcagcagaac ataccctcca 2520
ccctcctcca ggaccacgag aaccagcgac tctttgagat gcttggacga aaatgcttgg 2580
tgagctgggg atctcctgcc cccgccccgt ccccaccgtt tcttcctctt cctctcctcc 2640
ttctctctct tcccctcctc ccgctcctcc tttccctctc catcatctcc actcctagaa 2700
tttcccgtca taatccaccc ttcccaggaa gatctcaatg tcttcttgcc ttccctctgg 2760
ctgcagctct tcctttgggc ccatgactgt catgaggcag gaaggaccag gtctggctcc 2820
aagaccttgt ggctacccct gaccagactc cactgacccc tgctttcctc tcccagacgc 2880
tggccactgc agttgttcag ctgtacctgg cgctgccccc tggagctgag cactggacca 2940
aggagcattg tggggctgtg tgcttcgtga aggataaccc ccagaagtcc tacttcatcc 3000
gcctttacgg ccttcaggtg acccccccac ccccgactgg acttgcaagc cagttctcaa 3060
cccgcaaacc cagatctgtg tccatatgtg tccatagctt caagacctca gacctgatca 3120
gtgaatccct gagccccaga accaaagact catccagatg gcaaactctg acttgccttt 3180
ctaagtctgc aatgactggc cccagtctcc gtatcaagat ctctaaagcc cccagtatta 3240
gtctgctgcc taagcctaat cttttccaca aattccaata aatgagcact gtatttgtac 3300
ctgaacctca aatctattct aaactcaaca ttttgcatcc caggaatctc tcatcaaaac 3360
tcctgaaccc cagatgtttg ccaagctcct aagtcataaa tctgttcaac aaaccccaaa 3420
gttgaatatt ccattgatcc ttgaactcca aatctgtcct tctaaatcca cagcacagac 3480
cccagagttc ccatctagag catggctacg tagataagta gcatggcggg ttaatcatta 3540
actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca 3600
ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga 3660
gcgagcgagc gcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa 3720
cagttgcgca gcctgaatgg cgaatggcga ttccgttgca atggctggcg gtaatattgt 3780
tctggatatt accagcaagg ccgatagttt gagttcttct actcaggcaa gtgatgttat 3840
tactaatcaa agaagtattg cgacaacggt taatttgcgt gatggacaga ctcttttact 3900
cggtggcctc actgattata aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa 3960
aatcccttta atcggcctcc tgtttagctc ccgctctgat tctaacgagg aaagcacgtt 4020
atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg 4080
gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt 4140
tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc 4200
gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg 4260
attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga 4320
cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc 4380
ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa 4440
aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa 4500
tttaaatatt tgcttataca atcttcctgt ttttggggct tttctgatta tcaaccgggg 4560
tacatatgat tgacatgcta gttttacgat taccgttcat cgattctctt gtttgctcca 4620
gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc 4680
cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc 4740
cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat 4800
atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt 4860
attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt 4920
gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg 4980
atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc 5040
agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct 5100
gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc 5160
tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag 5220
ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg 5280
tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata 5340
cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga 5400
aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca 5460
ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat 5520
cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag 5580
agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc 5640
gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct 5700
cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca 5760
gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt 5820
ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat 5880
gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt 5940
gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta 6000
cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga 6060
ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt 6120
gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc 6180
gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct 6240
gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata 6300
ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt 6360
gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc 6420
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg 6480
caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact 6540
ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg 6600
tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg 6660
ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac 6720
tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca 6780
cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga 6840
gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc 6900
ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct 6960
gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg 7020
agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct 7080
tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc 7140
tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc 7200
gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat 7260
taatg                                                             7265



<210> 7
<211> 7047
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of Full chemically modified guide #1

<400> 7
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tgtatgacaa gcagaaagta atttgggagc tgcggggagg caagggtaag ggatggggaa 300
gtggaccaga ggcatatgcg tcattggcag tgtctaagca ctcacgatag gcgtggatca 360
caggggctcg ctctgtaatt aaaaggaaaa gggtttttgt tgtgttgttg ttgttgctgt 420
ttttgagaca agggtcttgc tctgtcatca tccaggctgg agtgcagtgg tgcagtctca 480
gctcactgca acctccgcct cctgggttca agcgattctc ctgcctcagc ctcctgagca 540
gctaggacta caggtgtgtg ccaccatgcc tggctaattt ttgtattttt tagtggaaat 600
ggggttttgc catgttgccc aggctcgtct tgaactcctg acctcaagtg atccactcgt 660
ctcggcctcc caaagtgctg ggattacagg tgtgagctat tgtccccagc caaaaggaaa 720
agttttactg tagtaaccct tccggactag ggacctcggg cctcagcctc aggctaccta 780
ggtgctttag aaaggaggcc acccaggccc atgactactc cttgccacag ggagccctgc 840
acacagatgt gctaagctct cgctgccagc cagagggagg agggtctgag ccagtcagaa 900
ggagatgggc cccagagagt aagaaagggg gaggaggacc caagctgatc caaaaggtgg 960
gtctaagcag tcaagtggag gagggttcca atctgatggc ggagggccca agctcagcct 1020
aacgaggagg ccaggcccac caaggggccc ctggaggact tgtttccctt gtcccttgtg 1080
gttttttgca tttcctgttc ccttgctgct cattgcggaa gttcctcttc ttaccctgca 1140
cccagagcct cgccagagaa gacaagggca gaaagcacca tgagtggggg cccaatggga 1200
ggaaggcccg ggggccgagg agcacgaaca gagaaacagg agaatatggg ccaaacagga 1260
tatctgtggt aagcagttcc tgccccggct cagggccaag aacagttgga acagcagaat 1320
atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag 1380
atggtcccca gatgcggtcc cgccctcagc agtttctaga gaaccatcag atgtttccag 1440
ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga actaaccaat cagttcgctt 1500
ctcgcttctg ttcgcgcgct tctgctcccc gagctctata taagcagagc tcgtttagtg 1560
aaccgtcaga tcgcctggag acgccatcca cgctgttttg acttccatag aaggatctcg 1620
aggccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg 1680
agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg 1740
ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct 1800
ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc 1860
acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca 1920
ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg 1980
acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc 2040
tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc 2100
agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc 2160
agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg 2220
acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc 2280
acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt 2340
acaagtaaac tagtgtcgac tgctttattt gtgaaatttg tgatgctatt gctttatttg 2400
taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc 2460
aggttcaggg ggaggtgtgg gaggtttttt aaaaatccac ccttcccagg aagatctcaa 2520
tgtctacttg ccttccctct ggctgcagct cttcctttgg gcccatgact gtcatgaggc 2580
aggaaggacc aggtctggct ccaagacctt gtggctaccc ctgaccagac tccactgacc 2640
cctgctttcc tctcccagac gctggccact gcagttgttc agctgtacct ggcgctgccc 2700
cctggagctg agcactggac caaggagcat tgtggggctg tgtgcttcgt gaaggataac 2760
ccccagaagt cctacttcat ccgcctttac ggccttcagg tgaccccccc acccccgact 2820
ggacttgcaa gccagttctc aacccgcaaa cccagatctg tgtccatatg tgtccatagc 2880
ttcaagacct cagacctgat cagtgaatcc ctgagcccca gaaccaaaga ctcatccaga 2940
tggcaaactc tgacttgcct ttctaagtct gcaatgactg gccccagtct ccgtatcaag 3000
atctctaaag cccccagtat tagtctgctg cctaagccta atcttttcca caaattccaa 3060
taaatgagca ctgtatttgt acctgaacct caaatctatt ctaaactcaa cattttgcat 3120
cccaggaatc tctcatcaaa actcctgaac cccagatgtt tgccaagctc ctaagtcata 3180
aatctgttca acaaacccca aagttgaata ttccattgat ccttgaactc caaatctgtc 3240
cttctaaatc cacagcacag accccagagt tcccatctag agcatggcta cgtagataag 3300
tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc 3360
tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc 3420
tttgcccggg cggcctcagt gagcgagcga gcgcgccagc tggcgtaata gcgaagaggc 3480
ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggc gattccgttg 3540
caatggctgg cggtaatatt gttctggata ttaccagcaa ggccgatagt ttgagttctt 3600
ctactcaggc aagtgatgtt attactaatc aaagaagtat tgcgacaacg gttaatttgc 3660
gtgatggaca gactctttta ctcggtggcc tcactgatta taaaaacact tctcaggatt 3720
ctggcgtacc gttcctgtct aaaatccctt taatcggcct cctgtttagc tcccgctctg 3780
attctaacga ggaaagcacg ttatacgtgc tcgtcaaagc aaccatagta cgcgccctgt 3840
agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc 3900
agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc 3960
tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg 4020
cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga 4080
tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc 4140
caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg 4200
ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt 4260
aacaaaatat taacgtttac aatttaaata tttgcttata caatcttcct gtttttgggg 4320
cttttctgat tatcaaccgg ggtacatatg attgacatgc tagttttacg attaccgttc 4380
atcgattctc ttgtttgctc cagactctca ggcaatgacc tgatagcctt tgtagagacc 4440
tctcaaaaat agctaccctc tccggcatga atttatcagc tagaacggtt gaatatcata 4500
ttgatggtga tttgactgtc tccggccttt ctcacccgtt tgaatcttta cctacacatt 4560
actcaggcat tgcatttaaa atatatgagg gttctaaaaa tttttatcct tgcgttgaaa 4620
taaaggcttc tcccgcaaaa gtattacagg gtcataatgt ttttggtaca accgatttag 4680
ctttatgctc tgaggcttta ttgcttaatt ttgctaattc tttgccttgc ctgtatgatt 4740
tattggatgt tggaatcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc 4800
acaccgcata tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc 4860
ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc 4920
ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc 4980
accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat 5040
gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc 5100
tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg 5160
ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc 5220
ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt 5280
gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 5340
caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 5400
ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 5460
cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 5520
gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 5580
taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 5640
tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 5700
agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 5760
caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 5820
ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 5880
tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 5940
agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 6000
tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc 6060
agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag 6120
gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc 6180
gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt 6240
tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt 6300
gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat 6360
accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc 6420
accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa 6480
gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg 6540
ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag 6600
atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag 6660
gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa 6720
cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt 6780
gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg 6840
gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc 6900
tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac 6960
cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct 7020
ccccgcgcgt tggccgattc attaatg                                     7047



<210> 8
<211> 3451
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of Full chemically modified guide #1

<400> 8
aagcttcccg gggggatctg ggccactccc tctctgcgcg ctcgctcgct cactgaggcc 60
gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga 120
gcgcgcagag agggagtggc caactccatc actaggggtt cctggagggg tggagtcgtg 180
acctaggcga tttaaattca tgtacaaaaa agcaggcttt aaaggaacca attcagtcga 240
ctggatccgg taccaaggtc gggcaggaag agggcctatt tcccatgatt ccttcatatt 300
tgcatatacg atacaaggct gttagagaga taattagaat taatttgact gtaaacacaa 360
agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag tttgcagttt 420
taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag tatttcgatt 480
tcttggcttt atatatcttg tggaaaggac gaaacaccgg tatgttctgc tgaaccgcgt 540
tttagagcta gaaatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg 600
caccgagtcg gtgctttttt tctagaccca gctttcttgt acaaagttgg cattaactag 660
tccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga 720
cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagaga gggacagatc 780
cgggcccgca tgcgtcgaca attcactggc cgtcgtttta caacgtcgtg actgggaaaa 840
ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa 900
tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg 960
gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatggtg 1020
cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac acccgccaac 1080
acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca gacaagctgt 1140
gaccgtctcc gggagctgca tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag 1200
acgaaagggc ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc 1260
ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt 1320
ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata 1380
atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt 1440
tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc 1500
tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat 1560
ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct 1620
atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca 1680
ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg 1740
catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa 1800
cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg 1860
ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga 1920
cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg 1980
cgaactactt actctagctt cccggcaaca attaatagac tggatggagg cggataaagt 2040
tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg 2100
agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc 2160
ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca 2220
gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc 2280
atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat 2340
cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc 2400
agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg 2460
ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct 2520
accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct 2580
tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct 2640
cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg 2700
gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc 2760
gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga 2820
gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg 2880
cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta 2940
tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg 3000
ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg 3060
ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat 3120
taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc 3180
agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc 3240
gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa 3300
cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc 3360
ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 3420
ccatgattac gccaagctct cgagatctag a                                3451

<210> 9
<211> 7691
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of Full chemically modified guide #1

<400> 9
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
ttgtacaaaa aagcaggctt taaaggaacc aattcagtcg actggatccg gtaccaaggt 300
cgggcaggaa gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc 360
tgttagagag ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac 420
gtgacgtaga aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat 480
ggactatcat atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt 540
gtggaaagga cgaaacaccg gtatgttctg ctgaaccgcg ttttagagct agaaatagca 600
agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt 660
tacgcgtgta tgacaagcag aaagtaattt gggagctgcg gggaggcaag ggtaagggat 720
ggggaagtgg accagaggca tatgcgtcat tggcagtgtc taagcactca cgataggcgt 780
ggatcacagg ggctcgctct gtaattaaaa ggaaaagggt ttttgttgtg ttgttgttgt 840
tgctgttttt gagacaaggg tcttgctctg tcatcatcca ggctggagtg cagtggtgca 900
gtctcagctc actgcaacct ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc 960
tgagcagcta ggactacagg tgtgtgccac catgcctggc taatttttgt attttttagt 1020
ggaaatgggg ttttgccatg ttgcccaggc tcgtcttgaa ctcctgacct caagtgatcc 1080
actcgtctcg gcctcccaaa gtgctgggat tacaggtgtg agctattgtc cccagccaaa 1140
aggaaaagtt ttactgtagt aacccttccg gactagggac ctcgggcctc agcctcaggc 1200
tacctaggtg ctttagaaag gaggccaccc aggcccatga ctactccttg ccacagggag 1260
ccctgcacac agatgtgcta agctctcgct gccagccaga gggaggaggg tctgagccag 1320
tcagaaggag atgggcccca gagagtaaga aagggggagg aggacccaag ctgatccaaa 1380
aggtgggtct aagcagtcaa gtggaggagg gttccaatct gatggcggag ggcccaagct 1440
cagcctaacg aggaggccag gcccaccaag gggcccctgg aggacttgtt tcccttgtcc 1500
cttgtggttt tttgcatttc ctgttccctt gctgctcatt gcggaagttc ctcttcttac 1560
cctgcaccca gagcctcgcc agagaagaca agggcagaaa gcaccatgag tgggggccca 1620
atgggaggaa ggcccggggg ccgaggagca cgaacagaga aacaggagaa tatgggccaa 1680
acaggatatc tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gttggaacag 1740
cagaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa 1800
gaacagatgg tccccagatg cggtcccgcc ctcagcagtt tctagagaac catcagatgt 1860
ttccagggtg ccccaaggac ctgaaatgac cctgtgcctt atttgaacta accaatcagt 1920
tcgcttctcg cttctgttcg cgcgcttctg ctccccgagc tctatataag cagagctcgt 1980
ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgactt ccatagaagg 2040
atctcgaggc caccatggtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc 2100
tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg 2160
gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg 2220
tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc agccgctacc 2280
ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg 2340
agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg 2400
agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca 2460
acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg 2520
acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca 2580
gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc 2640
tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc aacgagaagc 2700
gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg 2760
agctgtacaa gtaaactagt gtcgactgct ttatttgtga aatttgtgat gctattgctt 2820
tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta 2880
tgtttcaggt tcagggggag gtgtgggagg ttttttaaac agcggttcag cagaacatac 2940
cctccaccct cctccaggac cacgagaacc agcgactctt tgagatgctt ggacgaaaat 3000
gcttggtgag ctggggatct cctgcccccg ccccgtcccc accgtttctt cctcttcctc 3060
tcctccttct ctctcttccc ctcctcccgc tcctcctttc cctctccatc atctcctctc 3120
ctagaatttc ccgtcataat ccacccttcc caggaagatc tcaatgtcta cttgccttcc 3180
ctctggctgc agctcttcct ttgggcccat gactgtcatg aggcaggaag gaccaggtct 3240
ggctccaaga ccttgtggct acccctgacc agactccact gacccctgct ttcctctccc 3300
agacgctggc cactgcagtt gttcagctgt acctggcgct gccccctgga gctgagcact 3360
ggaccaagga gcattgtggg gctgtgtgct tcgtgaagga taacccccag aagtcctact 3420
tcatccgcct ttacggcctt caggtgaccc ccccaccccc gactggactt gcaagccagt 3480
tctcaacccg caaacccaga tctgtgtcca tatgtgtcca tagcttcaag acctcagacc 3540
tgatcagtga atccctgagc cccagaacca aagactcatc cagatggcaa actctgactt 3600
gcctttctaa gtctgcaatg actggcccca gtctccgtat caagatctct aaagccccca 3660
gtattagtct gctgcctaag cctaatcttt tccacaaatt ccaataaatg agcactgtat 3720
ttgtacctga acctcaaatc tattctaaac tcaacatttt gcatcccagg aatctctcat 3780
caaaactcct gaaccccaga tgtttgccaa gctcctaagt cataaatctg ttcaacaaac 3840
cccaaagttg aatattccat tgatccttga actccaaatc tgtccttcta aatccacagc 3900
acagacccca gagttcccat ctagagcatg gctacgtaga taagtagcat ggcgggttaa 3960
tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct 4020
cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct 4080
cagtgagcga gcgagcgcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct 4140
tcccaacagt tgcgcagcct gaatggcgaa tggcgattcc gttgcaatgg ctggcggtaa 4200
tattgttctg gatattacca gcaaggccga tagtttgagt tcttctactc aggcaagtga 4260
tgttattact aatcaaagaa gtattgcgac aacggttaat ttgcgtgatg gacagactct 4320
tttactcggt ggcctcactg attataaaaa cacttctcag gattctggcg taccgttcct 4380
gtctaaaatc cctttaatcg gcctcctgtt tagctcccgc tctgattcta acgaggaaag 4440
cacgttatac gtgctcgtca aagcaaccat agtacgcgcc ctgtagcggc gcattaagcg 4500
cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg 4560
ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc 4620
taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa 4680
aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc 4740
ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac 4800
tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt 4860
ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt 4920
ttacaattta aatatttgct tatacaatct tcctgttttt ggggcttttc tgattatcaa 4980
ccggggtaca tatgattgac atgctagttt tacgattacc gttcatcgat tctcttgttt 5040
gctccagact ctcaggcaat gacctgatag cctttgtaga gacctctcaa aaatagctac 5100
cctctccggc atgaatttat cagctagaac ggttgaatat catattgatg gtgatttgac 5160
tgtctccggc ctttctcacc cgtttgaatc tttacctaca cattactcag gcattgcatt 5220
taaaatatat gagggttcta aaaattttta tccttgcgtt gaaataaagg cttctcccgc 5280
aaaagtatta cagggtcata atgtttttgg tacaaccgat ttagctttat gctctgaggc 5340
tttattgctt aattttgcta attctttgcc ttgcctgtat gatttattgg atgttggaat 5400
cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catatggtgc 5460
actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca 5520
cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg 5580
accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga 5640
cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct 5700
tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc 5760
taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa 5820
tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt 5880
gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct 5940
gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc 6000
cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta 6060
tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac 6120
tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc 6180
atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac 6240
ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg 6300
gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac 6360
gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc 6420
gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt 6480
gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga 6540
gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc 6600
cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag 6660
atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca 6720
tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc 6780
ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca 6840
gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc 6900
tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta 6960
ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt 7020
ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc 7080
gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg 7140
ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg 7200
tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag 7260
ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc 7320
agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat 7380
agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg 7440
gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc 7500
tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt 7560
accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca 7620
gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg 7680
attcattaat g                                                      7691



<210> 10
<211> 100
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sequence of Full chemically modified guide #1

<400> 10
gguauguucu gcugaaccgc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60
cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                       100

<210> 11
<211> 984
<212> DNA
<213> Artificial Sequence

<220> 
<223> Upstream homology arm (common in #1201, #1262 and
      #1244)

<400> 11
gtatgacaag cagaaagtaa tttgggagct gcggggaggc aagggtaagg gatggggaag 60
tggaccagag gcatatgcgt cattggcagt gtctaagcac tcacgatagg cgtggatcac 120
aggggctcgc tctgtaatta aaaggaaaag ggtttttgtt gtgttgttgt tgttgctgtt 180
tttgagacaa gggtcttgct ctgtcatcat ccaggctgga gtgcagtggt gcagtctcag 240
ctcactgcaa cctccgcctc ctgggttcaa gcgattctcc tgcctcagcc tcctgagcag 300
ctaggactac aggtgtgtgc caccatgcct ggctaatttt tgtatttttt agtggaaatg 360
gggttttgcc atgttgccca ggctcgtctt gaactcctga cctcaagtga tccactcgtc 420
tcggcctccc aaagtgctgg gattacaggt gtgagctatt gtccccagcc aaaaggaaaa 480
gttttactgt agtaaccctt ccggactagg gacctcgggc ctcagcctca ggctacctag 540
gtgctttaga aaggaggcca cccaggccca tgactactcc ttgccacagg gagccctgca 600
cacagatgtg ctaagctctc gctgccagcc agagggagga gggtctgagc cagtcagaag 660
gagatgggcc ccagagagta agaaaggggg aggaggaccc aagctgatcc aaaaggtggg 720
tctaagcagt caagtggagg agggttccaa tctgatggcg gagggcccaa gctcagccta 780
acgaggaggc caggcccacc aaggggcccc tggaggactt gtttcccttg tcccttgtgg 840
ttttttgcat ttcctgttcc cttgctgctc attgcggaag ttcctcttct taccctgcac 900
ccagagcctc gccagagaag acaagggcag aaagcaccat gagtgggggc ccaatgggag 960
gaaggcccgg gggccgagga gcac                                        984

<210> 12
<211> 1000
<212> DNA
<213> Artificial Sequence

<220> 
<223> Downstream homology arm for #1201

<400> 12
cagcggttca gcagaacata ccctccaccc tcctccagga ccacgagaac cagcgactct 60
ttgagatgct tggacgaaaa tgcttggtga gctggggatc tcctgccccc gccccgtccc 120
caccgtttct tcctcttcct ctcctccttc tctctcttcc cctcctcccg ctcctccttt 180
ccctctccat catctcctct cctagaattt cccgtcataa tccacccttc ccaggaagat 240
ctcaatgtct acttgccttc cctctggctg cagctcttcc tttgggccca tgactgtcat 300
gaggcaggaa ggaccaggtc tggctccaag accttgtggc tacccctgac cagactccac 360
tgacccctgc tttcctctcc cagacgctgg ccactgcagt tgttcagctg tacctggcgc 420
tgccccctgg agctgagcac tggaccaagg agcattgtgg ggctgtgtgc ttcgtgaagg 480
ataaccccca gaagtcctac ttcatccgcc tttacggcct tcaggtgacc cccccacccc 540
cgactggact tgcaagccag ttctcaaccc gcaaacccag atctgtgtcc atatgtgtcc 600
atagcttcaa gacctcagac ctgatcagtg aatccctgag ccccagaacc aaagactcat 660
ccagatggca aactctgact tgcctttcta agtctgcaat gactggcccc agtctccgta 720
tcaagatctc taaagccccc agtattagtc tgctgcctaa gcctaatctt ttccacaaat 780
tccaataaat gagcactgta tttgtacctg aacctcaaat ctattctaaa ctcaacattt 840
tgcatcccag gaatctctca tcaaaactcc tgaaccccag atgtttgcca agctcctaag 900
tcataaatct gttcaacaaa ccccaaagtt gaatattcca ttgatccttg aactccaaat 960
ctgtccttct aaatccacag cacagacccc agagttccca                       1000

<210> 13
<211> 1000
<212> DNA
<213> Artificial Sequence

<220> 
<223> Downstream homology arm #1244

<400> 13
cagcggttca gcagaacata ccctccaccc tcctccagga ccacgagaac cagcgactct 60
ttgagatgct tggacgaaaa tgcttggtga gctggggatc tcctgccccc gccccgtccc 120
caccgtttct tcctcttcct ctcctccttc tctctcttcc cctcctcccg ctcctccttt 180
ccctctccat catctccact cctagaattt cccgtcataa tccacccttc ccaggaagat 240
ctcaatgtct tcttgccttc cctctggctg cagctcttcc tttgggccca tgactgtcat 300
gaggcaggaa ggaccaggtc tggctccaag accttgtggc tacccctgac cagactccac 360
tgacccctgc tttcctctcc cagacgctgg ccactgcagt tgttcagctg tacctggcgc 420
tgccccctgg agctgagcac tggaccaagg agcattgtgg ggctgtgtgc ttcgtgaagg 480
ataaccccca gaagtcctac ttcatccgcc tttacggcct tcaggtgacc cccccacccc 540
cgactggact tgcaagccag ttctcaaccc gcaaacccag atctgtgtcc atatgtgtcc 600
atagcttcaa gacctcagac ctgatcagtg aatccctgag ccccagaacc aaagactcat 660
ccagatggca aactctgact tgcctttcta agtctgcaat gactggcccc agtctccgta 720
tcaagatctc taaagccccc agtattagtc tgctgcctaa gcctaatctt ttccacaaat 780
tccaataaat gagcactgta tttgtacctg aacctcaaat ctattctaaa ctcaacattt 840
tgcatcccag gaatctctca tcaaaactcc tgaaccccag atgtttgcca agctcctaag 900
tcataaatct gttcaacaaa ccccaaagtt gaatattcca ttgatccttg aactccaaat 960
ctgtccttct aaatccacag cacagacccc agagttccca                       1000

<210> 14
<211> 782
<212> DNA
<213> Artificial Sequence

<220> 
<223> Downstream homology arm #1262

<400> 14
aatccaccct tcccaggaag atctcaatgt ctacttgcct tccctctggc tgcagctctt 60
cctttgggcc catgactgtc atgaggcagg aaggaccagg tctggctcca agaccttgtg 120
gctacccctg accagactcc actgacccct gctttcctct cccagacgct ggccactgca 180
gttgttcagc tgtacctggc gctgccccct ggagctgagc actggaccaa ggagcattgt 240
ggggctgtgt gcttcgtgaa ggataacccc cagaagtcct acttcatccg cctttacggc 300
cttcaggtga cccccccacc cccgactgga cttgcaagcc agttctcaac ccgcaaaccc 360
agatctgtgt ccatatgtgt ccatagcttc aagacctcag acctgatcag tgaatccctg 420
agccccagaa ccaaagactc atccagatgg caaactctga cttgcctttc taagtctgca 480
atgactggcc ccagtctccg tatcaagatc tctaaagccc ccagtattag tctgctgcct 540
aagcctaatc ttttccacaa attccaataa atgagcactg tatttgtacc tgaacctcaa 600
atctattcta aactcaacat tttgcatccc aggaatctct catcaaaact cctgaacccc 660
agatgtttgc caagctccta agtcataaat ctgttcaaca aaccccaaag ttgaatattc 720
cattgatcct tgaactccaa atctgtcctt ctaaatccac agcacagacc ccagagttcc 780
ca                                                                782

<210> 15
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS TALEN binding site on the genome
      (forward-TALEN)

<400> 15
ctcctagaat ttcccgt                                                17

<210> 16
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS TALEN binding site on the genome
      (reverse-TALEN)

<400> 16
aggaagatct caatgtct                                               18

<210> 17
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> TALEN cleavage site (spacer sequence)

<400> 17
cataatccac ccttccc                                                17

<210> 18
<211> 141
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS exon 2

<400> 18
acgctggcca ctgcagttgt tcagctgtac ctggcgctgc cccctggagc tgagcactgg 60
accaaggagc attgtggggc tgtgtgcttc gtgaaggata acccccagaa gtcctacttc 120
atccgccttt acggccttca g                                           141

<210> 19
<211> 189
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS exon 1 sequence

<400> 19
tcctcttctt accctgcacc cagagcctcg ccagagaaga caagggcaga aagcaccatg 60
agtgggggcc caatgggagg aaggcccggg ggccgaggag caccagcggt tcagcagaac 120
ataccctcca ccctcctcca ggaccacgag aaccagcgac tctttgagat gcttggacga 180
aaatgcttg                                                         189

<210> 20
<211> 7468
<212> DNA
<213> Artificial Sequence

<220> 
<223> pWNY.2xNLS.Cas9.mCherry

<400> 20
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca 60
cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg 120
ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc 180
accatacact tagtgtaata cgactcacta tagggagagc ggccgctttt tcagcaagat 240
taagccgcca ccatggcgcc gcggcctcct aagaagaagc ggaaagtcga attctacgta 300
atggacaaga agtactccat tgggctcgat atcggcacaa acagcgtcgg ctgggccgtc 360
attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc 420
cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa 480
gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc 540
tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg 600
ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc 660
aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag 720
aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat 780
atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat 840
gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg 900
atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg 960
cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat 1020
cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa 1080
gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc 1140
cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt 1200
ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt 1260
atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga 1320
cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc 1380
ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg 1440
gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc 1500
aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac 1560
gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt 1620
gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc 1680
agattcgcgt ggatgactcg caaatcagaa gagacaatca ctccctggaa cttcgaggaa 1740
gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa 1800
aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt 1860
tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg 1920
tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc 1980
gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc 2040
agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc 2100
attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc 2160
ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct 2220
catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg 2280
cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg 2340
gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac 2400
tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt 2460
cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc 2520
gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt 2580
atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg 2640
atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca 2700
gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg 2760
gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatcat 2820
atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc 2880
gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa 2940
aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg 3000
actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag 3060
cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac 3120
accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct 3180
aagctggtgt ccgatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat 3240
taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa 3300
tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa 3360
atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc 3420
aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga 3480
ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc 3540
gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta 3600
cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc 3660
gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct 3720
tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc 3780
aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac 3840
tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag 3900
tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg 3960
cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc 4020
cactatgaaa agctcaaagg ctctcccgaa gataatgagc agaagcagct gttcgtggaa 4080
caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg 4140
atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag 4200
cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg 4260
cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag 4320
gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc 4380
gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtggct 4440
agcggaagcg gaggtgaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat 4500
ccgggccctg tgagcaaggg cgaggaggat aacatggcca tcatcaagga gttcatgcgc 4560
ttcaaggtgc acatggaggg ctccgtgaac ggccacgagt tcgagatcga gggcgagggc 4620
gagggccgcc cctacgaggg cacccagacc gccaagctga aggtgaccaa gggtggcccc 4680
ctgcccttcg cctgggacat cctgtcccct cagttcatgt acggctccaa ggcctacgtg 4740
aagcaccccg ccgacatccc cgactacttg aagctgtcct tccccgaggg cttcaagtgg 4800
gagcgcgtga tgaacttcga ggacggcggc gtggtgaccg tgacccagga ctcctctctg 4860
caggacggcg agttcatcta caaggtgaag ctgcgcggca ccaacttccc ctccgacggc 4920
cccgtaatgc agaagaagac catgggctgg gaggcctcct ccgagcggat gtaccccgag 4980
gacggcgccc tgaagggcga gatcaagcag aggctgaagc tgaaggacgg cggccactac 5040
gacgctgagg tcaagaccac ctacaaggcc aagaagcccg tgcagctgcc cggcgcctac 5100
aacgtcaaca tcaagttgga catcacctcc cacaacgagg actacaccat cgtggaacag 5160
tacgaacgcg ccgagggccg ccactccacc ggcggcatgg acgagctgta caagtgaggt 5220
acccgtacga gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg 5280
ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa 5340
tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac 5400
ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt 5460
gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga 5520
gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca 5580
ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg 5640
ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt 5700
cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc 5760
ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct 5820
tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc 5880
gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta 5940
tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca 6000
gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag 6060
tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc tctgctgaag 6120
ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt 6180
agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa 6240
gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg 6300
attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga 6360
agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta 6420
atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc 6480
cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg 6540
ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga 6600
agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt 6660
tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt 6720
gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc 6780
caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc 6840
ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca 6900
gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag 6960
tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg 7020
tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa 7080
cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa 7140
cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga 7200
gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga 7260
atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg 7320
agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt 7380
ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa 7440
aataggcgta tcacgaggcc ctttcgtc                                    7468



<210> 21
<211> 3452
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1190 scAAV.U6.guideRNA2

<400> 21
aagcttcccg gggggatctg ggccactccc tctctgcgcg ctcgctcgct cactgaggcc 60
gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga 120
gcgcgcagag agggagtggc caactccatc actaggggtt cctggagggg tggagtcgtg 180
acctaggcga tttaaattca tgtacaaaaa agcaggcttt aaaggaacca attcagtcga 240
ctggatccgg taccaaggtc gggcaggaag agggcctatt tcccatgatt ccttcatatt 300
tgcatatacg atacaaggct gttagagaga taattagaat taatttgact gtaaacacaa 360
agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag tttgcagttt 420
taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag tatttcgatt 480
tcttggcttt atatatcttg tggaaaggac gaaacaccgc aaagagtcgc tggttctcgg 540
ttttagagct agaaatagca agttaaaata aggctagtcc gttatcaact tgaaaaagtg 600
gcaccgagtc ggtgcttttt ttctagaccc agctttcttg tacaaagttg gcattaacta 660
gtccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg 720
acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggacagat 780
ccgggcccgc atgcgtcgac aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa 840
accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta 900
atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat 960
ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt 1020
gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa 1080
cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg 1140
tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga 1200
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt 1260
cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt 1320
tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat 1380
aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt 1440
ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg 1500
ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga 1560
tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc 1620
tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac 1680
actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg 1740
gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca 1800
acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg 1860
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 1920
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 1980
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 2040
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 2100
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 2160
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 2220
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 2280
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 2340
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 2400
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 2460
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 2520
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 2580
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 2640
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 2700
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 2760
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 2820
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 2880
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 2940
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 3000
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 3060
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 3120
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 3180
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 3240
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 3300
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 3360
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 3420
accatgatta cgccaagctc tcgagatcta ga                               3452

<210> 22
<211> 3452
<212> DNA
<213> Artificial Sequence

<220> 
<223> #1191 scAAV.U6.guideRNA3

<400> 22
aagcttcccg gggggatctg ggccactccc tctctgcgcg ctcgctcgct cactgaggcc 60
gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga 120
gcgcgcagag agggagtggc caactccatc actaggggtt cctggagggg tggagtcgtg 180
acctaggcga tttaaattca tgtacaaaaa agcaggcttt aaaggaacca attcagtcga 240
ctggatccgg taccaaggtc gggcaggaag agggcctatt tcccatgatt ccttcatatt 300
tgcatatacg atacaaggct gttagagaga taattagaat taatttgact gtaaacacaa 360
agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag tttgcagttt 420
taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag tatttcgatt 480
tcttggcttt atatatcttg tggaaaggac gaaacaccgc aagcatctca aagagtcgcg 540
ttttagagct agaaatagca agttaaaata aggctagtcc gttatcaact tgaaaaagtg 600
gcaccgagtc ggtgcttttt ttctagaccc agctttcttg tacaaagttg gcattaacta 660
gtccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg 720
acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggacagat 780
ccgggcccgc atgcgtcgac aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa 840
accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta 900
atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat 960
ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt 1020
gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa 1080
cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg 1140
tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga 1200
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt 1260
cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt 1320
tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat 1380
aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt 1440
ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg 1500
ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga 1560
tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc 1620
tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac 1680
actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg 1740
gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca 1800
acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg 1860
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 1920
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 1980
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 2040
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 2100
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 2160
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 2220
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 2280
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 2340
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 2400
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 2460
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 2520
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 2580
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 2640
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 2700
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 2760
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 2820
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 2880
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 2940
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 3000
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 3060
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 3120
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 3180
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 3240
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 3300
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 3360
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 3420
accatgatta cgccaagctc tcgagatcta ga                               3452

<210> 23
<211> 3452
<212> DNA
<213> Artificial Sequence

<220> 
<223> #1192 scAAV.U6.guideRNA4

<400> 23
aagcttcccg gggggatctg ggccactccc tctctgcgcg ctcgctcgct cactgaggcc 60
gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga 120
gcgcgcagag agggagtggc caactccatc actaggggtt cctggagggg tggagtcgtg 180
acctaggcga tttaaattca tgtacaaaaa agcaggcttt aaaggaacca attcagtcga 240
ctggatccgg taccaaggtc gggcaggaag agggcctatt tcccatgatt ccttcatatt 300
tgcatatacg atacaaggct gttagagaga taattagaat taatttgact gtaaacacaa 360
agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag tttgcagttt 420
taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag tatttcgatt 480
tcttggcttt atatatcttg tggaaaggac gaaacaccga ccatgagtgg gggcccaatg 540
ttttagagct agaaatagca agttaaaata aggctagtcc gttatcaact tgaaaaagtg 600
gcaccgagtc ggtgcttttt ttctagaccc agctttcttg tacaaagttg gcattaacta 660
gtccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg 720
acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggacagat 780
ccgggcccgc atgcgtcgac aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa 840
accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta 900
atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat 960
ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcatatggt 1020
gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga cacccgccaa 1080
cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg 1140
tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga 1200
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt 1260
cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt 1320
tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat 1380
aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt 1440
ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg 1500
ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga 1560
tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc 1620
tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac 1680
actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg 1740
gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca 1800
acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg 1860
gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg 1920
acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg 1980
gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag 2040
ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg 2100
gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct 2160
cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac 2220
agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact 2280
catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga 2340
tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt 2400
cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct 2460
gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc 2520
taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc 2580
ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc 2640
tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg 2700
ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt 2760
cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg 2820
agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg 2880
gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt 2940
atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag 3000
gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt 3060
gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta 3120
ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt 3180
cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc 3240
cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca 3300
acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc 3360
cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg 3420
accatgatta cgccaagctc tcgagatcta ga                               3452

<210> 24
<211> 3036
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS TALEN #2 forward

<400> 24
atggcgccgc ggcctcctaa gaagaagcgg aaagtcgaat tcgtggatct gcgaacactg 60
ggctatagcc agcagcagca ggagaagatc aaacccaagg tgaggtccac agtcgcacag 120
caccatgaag ccctggtggg ccacgggttc actcacgctc atattgtcgc actgtctcag 180
catccagccg ctctgggaac cgtggcagtc acataccagc acatcattac tgccctgccc 240
gaggctaccc atgaagacat cgtgggagtc ggcaaacagt ggagcggcgc acgggccctg 300
gaggctctgc tgaccgacgc aggggaactg agaggacccc ctctgcagct ggatacaggg 360
cagctggtga agattgctaa gaggggaggg gtgacagcaa tggaagccgt ccacgcaagc 420
aggaacgcac tgacaggggc ccccctgaac ctgaccccgg accaagtggt ggctatcgcc 480
agccacgatg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc 540
caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacgg tggcggcaag 600
caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc 660
ccggaccaag tggtggctat cgccagcaac aatggcggca agcaagcgct cgaaacggtg 720
cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct 780
atcgccagca acaatggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg 840
ctgtgccagg accatggcct gactccggac caagtggtgg ctatcgccag ccacgatggc 900
ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc 960
ctgaccccgg accaagtggt ggctatcgcc agcaacggtg gcggcaagca agcgctcgaa 1020
acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgactcc ggaccaagtg 1080
gtggctatcg ccagcaacaa tggcggcaag caagcgctcg aaacggtgca gcggctgttg 1140
ccggtgctgt gccaggacca tggcctgacc ccggaccaag tggtggctat cgccagccac 1200
gatggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac 1260
catggcctga ccccggacca agtggtggct atcgccagca acattggcgg caagcaagcg 1320
ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gactccggac 1380
caagtggtgg ctatcgccag caacaatggc ggcaagcaag cgctcgaaac ggtgcagcgg 1440
ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc 1500
agccacgatg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc 1560
caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacgg tggcggcaag 1620
caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc 1680
ccggaccaag tggtggctat cgccagccac gatggcggca agcaagcgct cgaaacggtg 1740
cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct 1800
atcgccagca acggtggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg 1860
ctgtgccagg accatggcct gaccccggac caagtggtgg ctatcgccag caacggtggc 1920
ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc 1980
ctgactccgg accaagtggt ggctatcgcc agccacgatg gcggcaagca agcgctcgaa 2040
acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgacccc ggaccaagtg 2100
gtggctatcg ccagccacga tggcggcaag caagcgctcg aaacggtgca gcggctgttg 2160
ccggtgctgt gccaggacca tggcctgacc ccggaccaag tggtggctat cgccagcaac 2220
ggtggcggca agcaagcgct cgaaagcatt gtggcccagc tgagccggcc tgatccggcg 2280
ttggccgcgt tgaccaacga ccacctggtc gctctggctt gcctgggagg acgccctgct 2340
atggacgctg tgaagaaagg actgccccac gcacccgaac tgattagacg ggtgaaccgg 2400
agaatcggcg agagaacatc ccatagggtg gcaatctcta gaactcagct ggtcaagagt 2460
gaactggagg aaaagaaatc agagctgcgc cacaagctga aatacgtgcc tcatgagtat 2520
atcgaactga tcgagattgc tcgcaattca acccaggacc ggatcctgga aatgaaagtg 2580
atggagttct ttatgaaagt ctacggatat cgggggaaac acctgggagg gagcagaaag 2640
ccagatgggg ccatctacac agtgggatcc cccatcgact atggcgtgat tgtcgatact 2700
aaagcctaca gcggaggcta taacctgcct atcggccagg ctgacgagat gcagagatac 2760
gtggaggaaa accagacccg caataagcat attaacccca atgaatggtg gaaagtgtat 2820
cctagctccg tcacagagtt caagtttctg ttcgtgagcg gacactttaa gggcaactac 2880
aaagcacagc tgactaggct gaatcatatc accaactgca atggagccgt gctgtctgtc 2940
gaggaactgc tgatcggggg agagatgatt aaggctggca cactgactct ggaggaagtg 3000
aggcgcaagt tcaacaatgg ggaaatcaac ttctaa                           3036

<210> 25
<211> 2934
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS TALEN #2 Reverse

<400> 25
atggcgccgc ggcctcctaa gaagaagcgg aaagtcgaat tcgtggatct gcgaacactg 60
ggctatagcc agcagcagca ggagaagatc aaacccaagg tgaggtccac agtcgcacag 120
caccatgaag ccctggtggg ccacgggttc actcacgctc atattgtcgc actgtctcag 180
catccagccg ctctgggaac cgtggcagtc acataccagc acatcattac tgccctgccc 240
gaggctaccc atgaagacat cgtgggagtc ggcaaacagt ggagcggcgc acgggccctg 300
gaggctctgc tgaccgacgc aggggaactg agaggacccc ctctgcagct ggatacaggg 360
cagctggtga agattgctaa gaggggaggg gtgacagcaa tggaagccgt ccacgcaagc 420
aggaacgcac tgacaggggc ccccctgaac ctgaccccgg accaagtggt ggctatcgcc 480
agcaacaatg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc 540
caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacaa tggcggcaag 600
caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc 660
ccggaccaag tggtggctat cgccagcaac ggtggcggca agcaagcgct cgaaacggtg 720
cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct 780
atcgccagcc acgatggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg 840
ctgtgccagg accatggcct gactccggac caagtggtgg ctatcgccag ccacgatggc 900
ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc 960
ctgaccccgg accaagtggt ggctatcgcc agcaacggtg gcggcaagca agcgctcgaa 1020
acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgactcc ggaccaagtg 1080
gtggctatcg ccagcaacgg tggcggcaag caagcgctcg aaacggtgca gcggctgttg 1140
ccggtgctgt gccaggacca tggcctgacc ccggaccaag tggtggctat cgccagccac 1200
gatggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac 1260
catggcctga ccccggacca agtggtggct atcgccagcc acgatggcgg caagcaagcg 1320
ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gactccggac 1380
caagtggtgg ctatcgccag caacggtggc ggcaagcaag cgctcgaaac ggtgcagcgg 1440
ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc 1500
agcaacaatg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc 1560
caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagccacga tggcggcaag 1620
caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc 1680
ccggaccaag tggtggctat cgccagccac gatggcggca agcaagcgct cgaaacggtg 1740
cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct 1800
atcgccagca acggtggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg 1860
ctgtgccagg accatggcct gaccccggac caagtggtgg ctatcgccag ccacgatggc 1920
ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc 1980
ctgactccgg accaagtggt ggctatcgcc agcaacattg gcggcaagca agcgctcgaa 2040
acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgacccc ggaccaagtg 2100
gtggctatcg ccagcaacgg tggcggcaag caagcgctcg aaagcattgt ggcccagctg 2160
agccggcctg atccggcgtt ggccgcgttg accaacgacc acctggtcgc tctggcttgc 2220
ctgggaggac gccctgctat ggacgctgtg aagaaaggac tgccccacgc acccgaactg 2280
attagacggg tgaaccggag aatcggcgag agaacatccc atagggtggc aatctctaga 2340
actcagctgg tcaagagtga actggaggaa aagaaatcag agctgcgcca caagctgaaa 2400
tacgtgcctc atgagtatat cgaactgatc gagattgctc gcaattcaac ccaggaccgg 2460
atcctggaaa tgaaagtgat ggagttcttt atgaaagtct acggatatcg ggggaaacac 2520
ctgggaggga gcagaaagcc agatggggcc atctacacag tgggatcccc catcgactat 2580
ggcgtgattg tcgatactaa agcctacagc ggaggctata acctgcctat cggccaggct 2640
gacgagatgc agagatacgt ggaggaaaac cagacccgca ataagcatat taaccccaat 2700
gaatggtgga aagtgtatcc tagctccgtc acagagttca agtttctgtt cgtgagcgga 2760
cactttaagg gcaactacaa agcacagctg actaggctga atcatatcac caactgcaat 2820
ggagccgtgc tgtctgtcga ggaactgctg atcgggggag agatgattaa ggctggcaca 2880
ctgactctgg aggaagtgag gcgcaagttc aacaatgggg aaatcaactt ctaa       2934

<210> 26
<211> 7084
<212> DNA
<213> Artificial Sequence

<220> 
<223> #1380 AAV.WASATGcoWAS.WPRE3.pA

<400> 26
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
taggctcgtc ttgaactcct gacctcaagt gatccactcg tctcggcctc ccaaagtgct 300
gggattacag gtgtgagcta ttgtccccag ccaaaaggaa aagttttact gtagtaaccc 360
ttccggacta gggacctcgg gcctcagcct caggctacct aggtgcttta gaaaggaggc 420
cacccaggcc catgactact ccttgccaca gggagccctg cacacagatg tgctaagctc 480
tcgctgccag ccagagggag gagggtctga gccagtcaga aggagatggg ccccagagag 540
taagaaaggg ggaggaggac ccaagctgat ccaaaaggtg ggtctaagca gtcaagtgga 600
ggagggttcc aatctgatgg cggagggccc aagctcagcc taacgaggag gccaggccca 660
ccaaggggcc cctggaggac ttgtttccct tgtcccttgt ggttttttgc atttcctgtt 720
cccttgctgc tcattgcgga agttcctctt cttaccctgc acccagagcc tcgccagaga 780
agacaagggc agaaagcacc atgggaggaa gacccggcgg ccgaggagcg ccagcagtgc 840
aacaaaacat tccgtcaacc ctgctgcagg accacgaaaa ccagaggctg tttgaaatgt 900
tgggacggaa gtgtctcact ctcgccacag ccgtcgtcca gctttatctt gcgcttcctc 960
ccggtgctga gcattggact aaagagcatt gcggcgcggt ctgttttgtc aaggataatc 1020
cccaaaaatc atatttcatt aggttgtacg gactccaagc tggacgcctt ctgtgggaac 1080
aagaactcta tagccagctc gtatatagca caccgacccc tttcttccat actttcgcgg 1140
gagacgactg tcaggcgggc ttgaactttg cggacgagga tgaagctcag gctttccgag 1200
cattggttca agaaaaaatc cagaaaagaa atcagcgaca gtccggagat cgccggcagc 1260
tgccgccgcc acctacaccg gccaatgagg aacggagggg aggccttccg ccacttccat 1320
tgcatccagg cggcgatcag ggtgggccac cagtagggcc cttgagtttg ggtctcgcta 1380
ctgtggatat acagaacccg gacataacat ctagccgcta ccgcggactg ccggctccag 1440
gtccgtcccc cgctgataaa aagcgctccg gcaaaaagaa gatatctaaa gcagatatcg 1500
gtgcgccctc cggtttcaag catgtctccc atgtaggatg ggacccgcaa aatggattcg 1560
acgttaataa cctcgatccg gacctgagga gtctcttctc tcgcgcgggt atcagcgagg 1620
cacagcttac tgatgccgaa acaagtaagt tgatatacga ctttatcgag gatcaaggag 1680
ggctggaagc ggtcaggcaa gaaatgcggc gacaagaacc tttgcccccg cccccgcccc 1740
cgtccagagg cgggaaccag cttccacgcc cacctatcgt tggagggaat aaaggcaggt 1800
ctgggccact ccctccggta ccgttgggga tcgctccacc gcctcctacg cctaggggac 1860
ccccgcctcc tggtcggggg ggaccgcccc ctccgccgcc tccagccact ggtcgaagtg 1920
gacccctccc gcctcctcca cccggcgccg ggggcccacc gatgccacct cctcctccgc 1980
ccccaccgcc tcccccttct tccggcaacg gtcccgcacc tccgcccctc cctccggcat 2040
tggtccccgc ggggggcctc gcgcctggtg gtggccgggg tgcacttctg gatcaaatcc 2100
gacagggcat acagttgaat aagacgcccg gcgcccctga aagctcagct ctgcaaccgc 2160
cgcctcagtc ctctgaaggg ttggtaggcg cgctcatgca tgtaatgcag aagcgcagtc 2220
gcgctatcca ctcatcagat gaaggtgaag accaggccgg tgacgaggac gaagacgatg 2280
aatgggacga ttgactgaac tgaactagtg tcgacgataa tcaacctctg gattacaaaa 2340
tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg 2400
ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct 2460
tgtataaatc ctggttagtt cttgccacgg cggaactcat cgccgcctgc cttgcccgct 2520
gctggacagg ggctcggctg ttgggcactg acaattccgt gggtcgactg ctttatttgt 2580
gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac 2640
aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa 2700
acagcggttc agcagaacat accctccacc ctcctccagg accacgagaa ccagcgactc 2760
tttgagatgc ttggacgaaa atgcttggtg agctggggat ctcctgcccc cgccccgtcc 2820
ccaccgtttc ttcctcttcc tctcctcctt ctctctcttc ccctcctccc gctcctcctt 2880
tccctctcca tcatctcctc tcctagaatt tcccgtcata atccaccctt cccaggaaga 2940
tctcaatgtc tacttgcctt ccctctggct gcagctcttc ctttgggccc atgactgtca 3000
tgaggcagga aggaccaggt ctggctccaa gaccttgtgg ctacccctga ccagactcca 3060
ctgacccctg ctttcctctc ccagacgctg gccactgcag ttgttcagct gtacctggcg 3120
ctgccccctg gagctgagca ctggaccaag gagcattgtg gggctgtgtg cttcgtgaag 3180
gataaccccc agaagtccta cttcatccgc ctttacggcc ttcaggtgac ccccccaccc 3240
ccgactggac ttgcaagcca gttctcaacc cgcaaaccca gatctgtgtc catatgtgtc 3300
catagcttca agtctagagc atggctacgt agataagtag catggcgggt taatcattaa 3360
ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac 3420
tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag 3480
cgagcgagcg cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac 3540
agttgcgcag cctgaatggc gaatggcgat tccgttgcaa tggctggcgg taatattgtt 3600
ctggatatta ccagcaaggc cgatagtttg agttcttcta ctcaggcaag tgatgttatt 3660
actaatcaaa gaagtattgc gacaacggtt aatttgcgtg atggacagac tcttttactc 3720
ggtggcctca ctgattataa aaacacttct caggattctg gcgtaccgtt cctgtctaaa 3780
atccctttaa tcggcctcct gtttagctcc cgctctgatt ctaacgagga aagcacgtta 3840
tacgtgctcg tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg 3900
tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt 3960
cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg 4020
ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga 4080
ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac 4140
gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc 4200
tatctcggtc tattcttttg atttataagg gattttgccg atttcggcct attggttaaa 4260
aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat 4320
ttaaatattt gcttatacaa tcttcctgtt tttggggctt ttctgattat caaccggggt 4380
acatatgatt gacatgctag ttttacgatt accgttcatc gattctcttg tttgctccag 4440
actctcaggc aatgacctga tagcctttgt agagacctct caaaaatagc taccctctcc 4500
ggcatgaatt tatcagctag aacggttgaa tatcatattg atggtgattt gactgtctcc 4560
ggcctttctc acccgtttga atctttacct acacattact caggcattgc atttaaaata 4620
tatgagggtt ctaaaaattt ttatccttgc gttgaaataa aggcttctcc cgcaaaagta 4680
ttacagggtc ataatgtttt tggtacaacc gatttagctt tatgctctga ggctttattg 4740
cttaattttg ctaattcttt gccttgcctg tatgatttat tggatgttgg aatcgcctga 4800
tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg tgcactctca 4860
gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg 4920
acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct 4980
ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg 5040
gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt 5100
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac 5160
attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa 5220
aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat 5280
tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc 5340
agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga 5400
gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg 5460
cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc 5520
agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag 5580
taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc 5640
tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg 5700
taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg 5760
acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac 5820
ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac 5880
cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg 5940
agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg 6000
tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg 6060
agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac 6120
tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg 6180
ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg 6240
tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc 6300
aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc 6360
tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt 6420
agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc 6480
taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact 6540
caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac 6600
agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag 6660
aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg 6720
gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg 6780
tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga 6840
gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt 6900
ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct 6960
ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg 7020
aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt 7080
aatg                                                              7084



<210> 27
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS TALEN#1forward RVD sequence

<400> 27
ctcctagaat ttcccgt                                                17

<210> 28
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS TALEN#1 reverse RVD sequence

<400> 28
agacattgag atcttcct                                               18

<210> 29
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS TALEN#2 forward RVD sequence

<400> 29
ctggctgcag ctcttcct                                               18

<210> 30
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS TALEN#2 reverse RVD sequence

<400> 30
ggtccttcct gcctcat                                                17

<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS GUIDE#1 sequence

<400> 31
ggtatgttct gctgaaccgc                                             20

<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS GUIDE#2 sequence

<400> 32
caaagagtcg ctggttctcg                                             20

<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS GUIDE#3 sequence

<400> 33
caagcatctc aaagagtcgc                                             20

<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> WAS GUIDE#4 sequence

<400> 34
accatgagtg ggggcccaat                                             20

<210> 35
<211> 7265
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAAV.DT (#1201)

<400> 35
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tgtatgacaa gcagaaagta atttgggagc tgcggggagg caagggtaag ggatggggaa 300
gtggaccaga ggcatatgcg tcattggcag tgtctaagca ctcacgatag gcgtggatca 360
caggggctcg ctctgtaatt aaaaggaaaa gggtttttgt tgtgttgttg ttgttgctgt 420
ttttgagaca agggtcttgc tctgtcatca tccaggctgg agtgcagtgg tgcagtctca 480
gctcactgca acctccgcct cctgggttca agcgattctc ctgcctcagc ctcctgagca 540
gctaggacta caggtgtgtg ccaccatgcc tggctaattt ttgtattttt tagtggaaat 600
ggggttttgc catgttgccc aggctcgtct tgaactcctg acctcaagtg atccactcgt 660
ctcggcctcc caaagtgctg ggattacagg tgtgagctat tgtccccagc caaaaggaaa 720
agttttactg tagtaaccct tccggactag ggacctcggg cctcagcctc aggctaccta 780
ggtgctttag aaaggaggcc acccaggccc atgactactc cttgccacag ggagccctgc 840
acacagatgt gctaagctct cgctgccagc cagagggagg agggtctgag ccagtcagaa 900
ggagatgggc cccagagagt aagaaagggg gaggaggacc caagctgatc caaaaggtgg 960
gtctaagcag tcaagtggag gagggttcca atctgatggc ggagggccca agctcagcct 1020
aacgaggagg ccaggcccac caaggggccc ctggaggact tgtttccctt gtcccttgtg 1080
gttttttgca tttcctgttc ccttgctgct cattgcggaa gttcctcttc ttaccctgca 1140
cccagagcct cgccagagaa gacaagggca gaaagcacca tgagtggggg cccaatggga 1200
ggaaggcccg ggggccgagg agcacgaaca gagaaacagg agaatatggg ccaaacagga 1260
tatctgtggt aagcagttcc tgccccggct cagggccaag aacagttgga acagcagaat 1320
atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag 1380
atggtcccca gatgcggtcc cgccctcagc agtttctaga gaaccatcag atgtttccag 1440
ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga actaaccaat cagttcgctt 1500
ctcgcttctg ttcgcgcgct tctgctcccc gagctctata taagcagagc tcgtttagtg 1560
aaccgtcaga tcgcctggag acgccatcca cgctgttttg acttccatag aaggatctcg 1620
aggccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg 1680
agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg 1740
ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct 1800
ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc 1860
acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca 1920
ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg 1980
acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc 2040
tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc 2100
agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc 2160
agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg 2220
acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc 2280
acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt 2340
acaagtaaac tagtgtcgac tgctttattt gtgaaatttg tgatgctatt gctttatttg 2400
taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc 2460
aggttcaggg ggaggtgtgg gaggtttttt aaacagcggt tcagcagaac ataccctcca 2520
ccctcctcca ggaccacgag aaccagcgac tctttgagat gcttggacga aaatgcttgg 2580
tgagctgggg atctcctgcc cccgccccgt ccccaccgtt tcttcctctt cctctcctcc 2640
ttctctctct tcccctcctc ccgctcctcc tttccctctc catcatctcc tctcctagaa 2700
tttcccgtca taatccaccc ttcccaggaa gatctcaatg tctacttgcc ttccctctgg 2760
ctgcagctct tcctttgggc ccatgactgt catgaggcag gaaggaccag gtctggctcc 2820
aagaccttgt ggctacccct gaccagactc cactgacccc tgctttcctc tcccagacgc 2880
tggccactgc agttgttcag ctgtacctgg cgctgccccc tggagctgag cactggacca 2940
aggagcattg tggggctgtg tgcttcgtga aggataaccc ccagaagtcc tacttcatcc 3000
gcctttacgg ccttcaggtg acccccccac ccccgactgg acttgcaagc cagttctcaa 3060
cccgcaaacc cagatctgtg tccatatgtg tccatagctt caagacctca gacctgatca 3120
gtgaatccct gagccccaga accaaagact catccagatg gcaaactctg acttgccttt 3180
ctaagtctgc aatgactggc cccagtctcc gtatcaagat ctctaaagcc cccagtatta 3240
gtctgctgcc taagcctaat cttttccaca aattccaata aatgagcact gtatttgtac 3300
ctgaacctca aatctattct aaactcaaca ttttgcatcc caggaatctc tcatcaaaac 3360
tcctgaaccc cagatgtttg ccaagctcct aagtcataaa tctgttcaac aaaccccaaa 3420
gttgaatatt ccattgatcc ttgaactcca aatctgtcct tctaaatcca cagcacagac 3480
cccagagttc ccatctagag catggctacg tagataagta gcatggcggg ttaatcatta 3540
actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca 3600
ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga 3660
gcgagcgagc gcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa 3720
cagttgcgca gcctgaatgg cgaatggcga ttccgttgca atggctggcg gtaatattgt 3780
tctggatatt accagcaagg ccgatagttt gagttcttct actcaggcaa gtgatgttat 3840
tactaatcaa agaagtattg cgacaacggt taatttgcgt gatggacaga ctcttttact 3900
cggtggcctc actgattata aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa 3960
aatcccttta atcggcctcc tgtttagctc ccgctctgat tctaacgagg aaagcacgtt 4020
atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg 4080
gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt 4140
tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc 4200
gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg 4260
attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga 4320
cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc 4380
ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa 4440
aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa 4500
tttaaatatt tgcttataca atcttcctgt ttttggggct tttctgatta tcaaccgggg 4560
tacatatgat tgacatgcta gttttacgat taccgttcat cgattctctt gtttgctcca 4620
gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc 4680
cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc 4740
cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat 4800
atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt 4860
attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt 4920
gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg 4980
atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc 5040
agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct 5100
gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc 5160
tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag 5220
ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg 5280
tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata 5340
cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga 5400
aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca 5460
ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat 5520
cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag 5580
agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc 5640
gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct 5700
cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca 5760
gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt 5820
ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat 5880
gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt 5940
gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta 6000
cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga 6060
ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt 6120
gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc 6180
gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct 6240
gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata 6300
ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt 6360
gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc 6420
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg 6480
caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact 6540
ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg 6600
tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg 6660
ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac 6720
tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca 6780
cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga 6840
gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc 6900
ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct 6960
gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg 7020
agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct 7080
tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc 7140
tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc 7200
gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat 7260
taatg                                                             7265



<210> 36
<211> 7265
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAAV.DT-M (#1244)

<400> 36
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tgtatgacaa gcagaaagta atttgggagc tgcggggagg caagggtaag ggatggggaa 300
gtggaccaga ggcatatgcg tcattggcag tgtctaagca ctcacgatag gcgtggatca 360
caggggctcg ctctgtaatt aaaaggaaaa gggtttttgt tgtgttgttg ttgttgctgt 420
ttttgagaca agggtcttgc tctgtcatca tccaggctgg agtgcagtgg tgcagtctca 480
gctcactgca acctccgcct cctgggttca agcgattctc ctgcctcagc ctcctgagca 540
gctaggacta caggtgtgtg ccaccatgcc tggctaattt ttgtattttt tagtggaaat 600
ggggttttgc catgttgccc aggctcgtct tgaactcctg acctcaagtg atccactcgt 660
ctcggcctcc caaagtgctg ggattacagg tgtgagctat tgtccccagc caaaaggaaa 720
agttttactg tagtaaccct tccggactag ggacctcggg cctcagcctc aggctaccta 780
ggtgctttag aaaggaggcc acccaggccc atgactactc cttgccacag ggagccctgc 840
acacagatgt gctaagctct cgctgccagc cagagggagg agggtctgag ccagtcagaa 900
ggagatgggc cccagagagt aagaaagggg gaggaggacc caagctgatc caaaaggtgg 960
gtctaagcag tcaagtggag gagggttcca atctgatggc ggagggccca agctcagcct 1020
aacgaggagg ccaggcccac caaggggccc ctggaggact tgtttccctt gtcccttgtg 1080
gttttttgca tttcctgttc ccttgctgct cattgcggaa gttcctcttc ttaccctgca 1140
cccagagcct cgccagagaa gacaagggca gaaagcacca tgagtggggg cccaatggga 1200
ggaaggcccg ggggccgagg agcacgaaca gagaaacagg agaatatggg ccaaacagga 1260
tatctgtggt aagcagttcc tgccccggct cagggccaag aacagttgga acagcagaat 1320
atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag 1380
atggtcccca gatgcggtcc cgccctcagc agtttctaga gaaccatcag atgtttccag 1440
ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga actaaccaat cagttcgctt 1500
ctcgcttctg ttcgcgcgct tctgctcccc gagctctata taagcagagc tcgtttagtg 1560
aaccgtcaga tcgcctggag acgccatcca cgctgttttg acttccatag aaggatctcg 1620
aggccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg 1680
agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg 1740
ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct 1800
ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc 1860
acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca 1920
ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg 1980
acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc 2040
tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc 2100
agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc 2160
agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg 2220
acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc 2280
acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt 2340
acaagtaaac tagtgtcgac tgctttattt gtgaaatttg tgatgctatt gctttatttg 2400
taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc 2460
aggttcaggg ggaggtgtgg gaggtttttt aaacagcggt tcagcagaac ataccctcca 2520
ccctcctcca ggaccacgag aaccagcgac tctttgagat gcttggacga aaatgcttgg 2580
tgagctgggg atctcctgcc cccgccccgt ccccaccgtt tcttcctctt cctctcctcc 2640
ttctctctct tcccctcctc ccgctcctcc tttccctctc catcatctcc actcctagaa 2700
tttcccgtca taatccaccc ttcccaggaa gatctcaatg tcttcttgcc ttccctctgg 2760
ctgcagctct tcctttgggc ccatgactgt catgaggcag gaaggaccag gtctggctcc 2820
aagaccttgt ggctacccct gaccagactc cactgacccc tgctttcctc tcccagacgc 2880
tggccactgc agttgttcag ctgtacctgg cgctgccccc tggagctgag cactggacca 2940
aggagcattg tggggctgtg tgcttcgtga aggataaccc ccagaagtcc tacttcatcc 3000
gcctttacgg ccttcaggtg acccccccac ccccgactgg acttgcaagc cagttctcaa 3060
cccgcaaacc cagatctgtg tccatatgtg tccatagctt caagacctca gacctgatca 3120
gtgaatccct gagccccaga accaaagact catccagatg gcaaactctg acttgccttt 3180
ctaagtctgc aatgactggc cccagtctcc gtatcaagat ctctaaagcc cccagtatta 3240
gtctgctgcc taagcctaat cttttccaca aattccaata aatgagcact gtatttgtac 3300
ctgaacctca aatctattct aaactcaaca ttttgcatcc caggaatctc tcatcaaaac 3360
tcctgaaccc cagatgtttg ccaagctcct aagtcataaa tctgttcaac aaaccccaaa 3420
gttgaatatt ccattgatcc ttgaactcca aatctgtcct tctaaatcca cagcacagac 3480
cccagagttc ccatctagag catggctacg tagataagta gcatggcggg ttaatcatta 3540
actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca 3600
ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga 3660
gcgagcgagc gcgccagctg gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa 3720
cagttgcgca gcctgaatgg cgaatggcga ttccgttgca atggctggcg gtaatattgt 3780
tctggatatt accagcaagg ccgatagttt gagttcttct actcaggcaa gtgatgttat 3840
tactaatcaa agaagtattg cgacaacggt taatttgcgt gatggacaga ctcttttact 3900
cggtggcctc actgattata aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa 3960
aatcccttta atcggcctcc tgtttagctc ccgctctgat tctaacgagg aaagcacgtt 4020
atacgtgctc gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg 4080
gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt 4140
tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc 4200
gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg 4260
attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga 4320
cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc 4380
ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa 4440
aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtttacaa 4500
tttaaatatt tgcttataca atcttcctgt ttttggggct tttctgatta tcaaccgggg 4560
tacatatgat tgacatgcta gttttacgat taccgttcat cgattctctt gtttgctcca 4620
gactctcagg caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc 4680
cggcatgaat ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc 4740
cggcctttct cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat 4800
atatgagggt tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt 4860
attacagggt cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt 4920
gcttaatttt gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg 4980
atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc 5040
agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct 5100
gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc 5160
tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag 5220
ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg 5280
tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata 5340
cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga 5400
aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca 5460
ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat 5520
cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag 5580
agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc 5640
gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct 5700
cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca 5760
gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt 5820
ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat 5880
gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt 5940
gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta 6000
cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga 6060
ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt 6120
gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc 6180
gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct 6240
gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata 6300
ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt 6360
gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc 6420
gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg 6480
caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact 6540
ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg 6600
tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg 6660
ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac 6720
tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca 6780
cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga 6840
gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc 6900
ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct 6960
gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg 7020
agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct 7080
tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc 7140
tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc 7200
gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat 7260
taatg                                                             7265



<210> 37
<211> 7047
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAAV.DT-D (#1262)

<400> 37
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tgtatgacaa gcagaaagta atttgggagc tgcggggagg caagggtaag ggatggggaa 300
gtggaccaga ggcatatgcg tcattggcag tgtctaagca ctcacgatag gcgtggatca 360
caggggctcg ctctgtaatt aaaaggaaaa gggtttttgt tgtgttgttg ttgttgctgt 420
ttttgagaca agggtcttgc tctgtcatca tccaggctgg agtgcagtgg tgcagtctca 480
gctcactgca acctccgcct cctgggttca agcgattctc ctgcctcagc ctcctgagca 540
gctaggacta caggtgtgtg ccaccatgcc tggctaattt ttgtattttt tagtggaaat 600
ggggttttgc catgttgccc aggctcgtct tgaactcctg acctcaagtg atccactcgt 660
ctcggcctcc caaagtgctg ggattacagg tgtgagctat tgtccccagc caaaaggaaa 720
agttttactg tagtaaccct tccggactag ggacctcggg cctcagcctc aggctaccta 780
ggtgctttag aaaggaggcc acccaggccc atgactactc cttgccacag ggagccctgc 840
acacagatgt gctaagctct cgctgccagc cagagggagg agggtctgag ccagtcagaa 900
ggagatgggc cccagagagt aagaaagggg gaggaggacc caagctgatc caaaaggtgg 960
gtctaagcag tcaagtggag gagggttcca atctgatggc ggagggccca agctcagcct 1020
aacgaggagg ccaggcccac caaggggccc ctggaggact tgtttccctt gtcccttgtg 1080
gttttttgca tttcctgttc ccttgctgct cattgcggaa gttcctcttc ttaccctgca 1140
cccagagcct cgccagagaa gacaagggca gaaagcacca tgagtggggg cccaatggga 1200
ggaaggcccg ggggccgagg agcacgaaca gagaaacagg agaatatggg ccaaacagga 1260
tatctgtggt aagcagttcc tgccccggct cagggccaag aacagttgga acagcagaat 1320
atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag 1380
atggtcccca gatgcggtcc cgccctcagc agtttctaga gaaccatcag atgtttccag 1440
ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga actaaccaat cagttcgctt 1500
ctcgcttctg ttcgcgcgct tctgctcccc gagctctata taagcagagc tcgtttagtg 1560
aaccgtcaga tcgcctggag acgccatcca cgctgttttg acttccatag aaggatctcg 1620
aggccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg 1680
agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg 1740
ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct 1800
ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc 1860
acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca 1920
ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg 1980
acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc 2040
tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc 2100
agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc 2160
agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg 2220
acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc 2280
acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt 2340
acaagtaaac tagtgtcgac tgctttattt gtgaaatttg tgatgctatt gctttatttg 2400
taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc 2460
aggttcaggg ggaggtgtgg gaggtttttt aaaaatccac ccttcccagg aagatctcaa 2520
tgtctacttg ccttccctct ggctgcagct cttcctttgg gcccatgact gtcatgaggc 2580
aggaaggacc aggtctggct ccaagacctt gtggctaccc ctgaccagac tccactgacc 2640
cctgctttcc tctcccagac gctggccact gcagttgttc agctgtacct ggcgctgccc 2700
cctggagctg agcactggac caaggagcat tgtggggctg tgtgcttcgt gaaggataac 2760
ccccagaagt cctacttcat ccgcctttac ggccttcagg tgaccccccc acccccgact 2820
ggacttgcaa gccagttctc aacccgcaaa cccagatctg tgtccatatg tgtccatagc 2880
ttcaagacct cagacctgat cagtgaatcc ctgagcccca gaaccaaaga ctcatccaga 2940
tggcaaactc tgacttgcct ttctaagtct gcaatgactg gccccagtct ccgtatcaag 3000
atctctaaag cccccagtat tagtctgctg cctaagccta atcttttcca caaattccaa 3060
taaatgagca ctgtatttgt acctgaacct caaatctatt ctaaactcaa cattttgcat 3120
cccaggaatc tctcatcaaa actcctgaac cccagatgtt tgccaagctc ctaagtcata 3180
aatctgttca acaaacccca aagttgaata ttccattgat ccttgaactc caaatctgtc 3240
cttctaaatc cacagcacag accccagagt tcccatctag agcatggcta cgtagataag 3300
tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc 3360
tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc 3420
tttgcccggg cggcctcagt gagcgagcga gcgcgccagc tggcgtaata gcgaagaggc 3480
ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggc gattccgttg 3540
caatggctgg cggtaatatt gttctggata ttaccagcaa ggccgatagt ttgagttctt 3600
ctactcaggc aagtgatgtt attactaatc aaagaagtat tgcgacaacg gttaatttgc 3660
gtgatggaca gactctttta ctcggtggcc tcactgatta taaaaacact tctcaggatt 3720
ctggcgtacc gttcctgtct aaaatccctt taatcggcct cctgtttagc tcccgctctg 3780
attctaacga ggaaagcacg ttatacgtgc tcgtcaaagc aaccatagta cgcgccctgt 3840
agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc 3900
agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc 3960
tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg 4020
cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga 4080
tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc 4140
caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg 4200
ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt 4260
aacaaaatat taacgtttac aatttaaata tttgcttata caatcttcct gtttttgggg 4320
cttttctgat tatcaaccgg ggtacatatg attgacatgc tagttttacg attaccgttc 4380
atcgattctc ttgtttgctc cagactctca ggcaatgacc tgatagcctt tgtagagacc 4440
tctcaaaaat agctaccctc tccggcatga atttatcagc tagaacggtt gaatatcata 4500
ttgatggtga tttgactgtc tccggccttt ctcacccgtt tgaatcttta cctacacatt 4560
actcaggcat tgcatttaaa atatatgagg gttctaaaaa tttttatcct tgcgttgaaa 4620
taaaggcttc tcccgcaaaa gtattacagg gtcataatgt ttttggtaca accgatttag 4680
ctttatgctc tgaggcttta ttgcttaatt ttgctaattc tttgccttgc ctgtatgatt 4740
tattggatgt tggaatcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc 4800
acaccgcata tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc 4860
ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc 4920
ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc 4980
accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat 5040
gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc 5100
tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg 5160
ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc 5220
ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt 5280
gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 5340
caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 5400
ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 5460
cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 5520
gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 5580
taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 5640
tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 5700
agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 5760
caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 5820
ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 5880
tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 5940
agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 6000
tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc 6060
agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag 6120
gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc 6180
gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt 6240
tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt 6300
gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat 6360
accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc 6420
accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa 6480
gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg 6540
ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag 6600
atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag 6660
gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa 6720
cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt 6780
gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg 6840
gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc 6900
tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac 6960
cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct 7020
ccccgcgcgt tggccgattc attaatg                                     7047



<210> 38
<211> 3451
<212> DNA
<213> Artificial Sequence

<220> 
<223> pscAAV.G(#1189)

<400> 38
aagcttcccg gggggatctg ggccactccc tctctgcgcg ctcgctcgct cactgaggcc 60
gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga 120
gcgcgcagag agggagtggc caactccatc actaggggtt cctggagggg tggagtcgtg 180
acctaggcga tttaaattca tgtacaaaaa agcaggcttt aaaggaacca attcagtcga 240
ctggatccgg taccaaggtc gggcaggaag agggcctatt tcccatgatt ccttcatatt 300
tgcatatacg atacaaggct gttagagaga taattagaat taatttgact gtaaacacaa 360
agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag tttgcagttt 420
taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag tatttcgatt 480
tcttggcttt atatatcttg tggaaaggac gaaacaccgg tatgttctgc tgaaccgcgt 540
tttagagcta gaaatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg 600
caccgagtcg gtgctttttt tctagaccca gctttcttgt acaaagttgg cattaactag 660
tccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga 720
cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagaga gggacagatc 780
cgggcccgca tgcgtcgaca attcactggc cgtcgtttta caacgtcgtg actgggaaaa 840
ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa 900
tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg 960
gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatggtg 1020
cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac acccgccaac 1080
acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca gacaagctgt 1140
gaccgtctcc gggagctgca tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag 1200
acgaaagggc ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc 1260
ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt 1320
ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata 1380
atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt 1440
tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc 1500
tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat 1560
ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct 1620
atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca 1680
ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg 1740
catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa 1800
cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg 1860
ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga 1920
cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg 1980
cgaactactt actctagctt cccggcaaca attaatagac tggatggagg cggataaagt 2040
tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg 2100
agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc 2160
ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca 2220
gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc 2280
atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat 2340
cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc 2400
agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg 2460
ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct 2520
accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct 2580
tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct 2640
cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg 2700
gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc 2760
gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga 2820
gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg 2880
cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta 2940
tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg 3000
ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg 3060
ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat 3120
taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc 3180
agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc 3240
gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa 3300
cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc 3360
ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 3420
ccatgattac gccaagctct cgagatctag a                                3451

<210> 39
<211> 7691
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAAV.DTG(#1215)

<400> 39
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
ttgtacaaaa aagcaggctt taaaggaacc aattcagtcg actggatccg gtaccaaggt 300
cgggcaggaa gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc 360
tgttagagag ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac 420
gtgacgtaga aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat 480
ggactatcat atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt 540
gtggaaagga cgaaacaccg gtatgttctg ctgaaccgcg ttttagagct agaaatagca 600
agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt 660
tacgcgtgta tgacaagcag aaagtaattt gggagctgcg gggaggcaag ggtaagggat 720
ggggaagtgg accagaggca tatgcgtcat tggcagtgtc taagcactca cgataggcgt 780
ggatcacagg ggctcgctct gtaattaaaa ggaaaagggt ttttgttgtg ttgttgttgt 840
tgctgttttt gagacaaggg tcttgctctg tcatcatcca ggctggagtg cagtggtgca 900
gtctcagctc actgcaacct ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc 960
tgagcagcta ggactacagg tgtgtgccac catgcctggc taatttttgt attttttagt 1020
ggaaatgggg ttttgccatg ttgcccaggc tcgtcttgaa ctcctgacct caagtgatcc 1080
actcgtctcg gcctcccaaa gtgctgggat tacaggtgtg agctattgtc cccagccaaa 1140
aggaaaagtt ttactgtagt aacccttccg gactagggac ctcgggcctc agcctcaggc 1200
tacctaggtg ctttagaaag gaggccaccc aggcccatga ctactccttg ccacagggag 1260
ccctgcacac agatgtgcta agctctcgct gccagccaga gggaggaggg tctgagccag 1320
tcagaaggag atgggcccca gagagtaaga aagggggagg aggacccaag ctgatccaaa 1380
aggtgggtct aagcagtcaa gtggaggagg gttccaatct gatggcggag ggcccaagct 1440
cagcctaacg aggaggccag gcccaccaag gggcccctgg aggacttgtt tcccttgtcc 1500
cttgtggttt tttgcatttc ctgttccctt gctgctcatt gcggaagttc ctcttcttac 1560
cctgcaccca gagcctcgcc agagaagaca agggcagaaa gcaccatgag tgggggccca 1620
atgggaggaa ggcccggggg ccgaggagca cgaacagaga aacaggagaa tatgggccaa 1680
acaggatatc tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gttggaacag 1740
cagaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa 1800
gaacagatgg tccccagatg cggtcccgcc ctcagcagtt tctagagaac catcagatgt 1860
ttccagggtg ccccaaggac ctgaaatgac cctgtgcctt atttgaacta accaatcagt 1920
tcgcttctcg cttctgttcg cgcgcttctg ctccccgagc tctatataag cagagctcgt 1980
ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgactt ccatagaagg 2040
atctcgaggc caccatggtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc 2100
tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg 2160
gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg 2220
tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc agccgctacc 2280
ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg 2340
agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg 2400
agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca 2460
acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg 2520
acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca 2580
gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc 2640
tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc aacgagaagc 2700
gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg 2760
agctgtacaa gtaaactagt gtcgactgct ttatttgtga aatttgtgat gctattgctt 2820
tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta 2880
tgtttcaggt tcagggggag gtgtgggagg ttttttaaac agcggttcag cagaacatac 2940
cctccaccct cctccaggac cacgagaacc agcgactctt tgagatgctt ggacgaaaat 3000
gcttggtgag ctggggatct cctgcccccg ccccgtcccc accgtttctt cctcttcctc 3060
tcctccttct ctctcttccc ctcctcccgc tcctcctttc cctctccatc atctcctctc 3120
ctagaatttc ccgtcataat ccacccttcc caggaagatc tcaatgtcta cttgccttcc 3180
ctctggctgc agctcttcct ttgggcccat gactgtcatg aggcaggaag gaccaggtct 3240
ggctccaaga ccttgtggct acccctgacc agactccact gacccctgct ttcctctccc 3300
agacgctggc cactgcagtt gttcagctgt acctggcgct gccccctgga gctgagcact 3360
ggaccaagga gcattgtggg gctgtgtgct tcgtgaagga taacccccag aagtcctact 3420
tcatccgcct ttacggcctt caggtgaccc ccccaccccc gactggactt gcaagccagt 3480
tctcaacccg caaacccaga tctgtgtcca tatgtgtcca tagcttcaag acctcagacc 3540
tgatcagtga atccctgagc cccagaacca aagactcatc cagatggcaa actctgactt 3600
gcctttctaa gtctgcaatg actggcccca gtctccgtat caagatctct aaagccccca 3660
gtattagtct gctgcctaag cctaatcttt tccacaaatt ccaataaatg agcactgtat 3720
ttgtacctga acctcaaatc tattctaaac tcaacatttt gcatcccagg aatctctcat 3780
caaaactcct gaaccccaga tgtttgccaa gctcctaagt cataaatctg ttcaacaaac 3840
cccaaagttg aatattccat tgatccttga actccaaatc tgtccttcta aatccacagc 3900
acagacccca gagttcccat ctagagcatg gctacgtaga taagtagcat ggcgggttaa 3960
tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct 4020
cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct 4080
cagtgagcga gcgagcgcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct 4140
tcccaacagt tgcgcagcct gaatggcgaa tggcgattcc gttgcaatgg ctggcggtaa 4200
tattgttctg gatattacca gcaaggccga tagtttgagt tcttctactc aggcaagtga 4260
tgttattact aatcaaagaa gtattgcgac aacggttaat ttgcgtgatg gacagactct 4320
tttactcggt ggcctcactg attataaaaa cacttctcag gattctggcg taccgttcct 4380
gtctaaaatc cctttaatcg gcctcctgtt tagctcccgc tctgattcta acgaggaaag 4440
cacgttatac gtgctcgtca aagcaaccat agtacgcgcc ctgtagcggc gcattaagcg 4500
cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg 4560
ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc 4620
taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa 4680
aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc 4740
ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac 4800
tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt 4860
ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt 4920
ttacaattta aatatttgct tatacaatct tcctgttttt ggggcttttc tgattatcaa 4980
ccggggtaca tatgattgac atgctagttt tacgattacc gttcatcgat tctcttgttt 5040
gctccagact ctcaggcaat gacctgatag cctttgtaga gacctctcaa aaatagctac 5100
cctctccggc atgaatttat cagctagaac ggttgaatat catattgatg gtgatttgac 5160
tgtctccggc ctttctcacc cgtttgaatc tttacctaca cattactcag gcattgcatt 5220
taaaatatat gagggttcta aaaattttta tccttgcgtt gaaataaagg cttctcccgc 5280
aaaagtatta cagggtcata atgtttttgg tacaaccgat ttagctttat gctctgaggc 5340
tttattgctt aattttgcta attctttgcc ttgcctgtat gatttattgg atgttggaat 5400
cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catatggtgc 5460
actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca 5520
cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg 5580
accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga 5640
cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct 5700
tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc 5760
taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa 5820
tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt 5880
gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct 5940
gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc 6000
cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta 6060
tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac 6120
tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc 6180
atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac 6240
ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg 6300
gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac 6360
gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc 6420
gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt 6480
gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga 6540
gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc 6600
cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag 6660
atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca 6720
tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc 6780
ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca 6840
gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc 6900
tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta 6960
ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt 7020
ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc 7080
gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg 7140
ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg 7200
tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag 7260
ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc 7320
agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat 7380
agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg 7440
gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc 7500
tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt 7560
accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca 7620
gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg 7680
attcattaat g                                                      7691



<210> 40
<211> 6289
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAAV.ATG.GFP (#1374)

<400> 40
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
taggctcgtc ttgaactcct gacctcaagt gatccactcg tctcggcctc ccaaagtgct 300
gggattacag gtgtgagcta ttgtccccag ccaaaaggaa aagttttact gtagtaaccc 360
ttccggacta gggacctcgg gcctcagcct caggctacct aggtgcttta gaaaggaggc 420
cacccaggcc catgactact ccttgccaca gggagccctg cacacagatg tgctaagctc 480
tcgctgccag ccagagggag gagggtctga gccagtcaga aggagatggg ccccagagag 540
taagaaaggg ggaggaggac ccaagctgat ccaaaaggtg ggtctaagca gtcaagtgga 600
ggagggttcc aatctgatgg cggagggccc aagctcagcc taacgaggag gccaggccca 660
ccaaggggcc cctggaggac ttgtttccct tgtcccttgt ggttttttgc atttcctgtt 720
cccttgctgc tcattgcgga agttcctctt cttaccctgc acccagagcc tcgccagaga 780
agacaagggc agaaagcacc atggtgagca agggcgagga gctgttcacc ggggtggtgc 840
ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg 900
gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc accggcaagc 960
tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc 1020
gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc gaaggctacg 1080
tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc gccgaggtga 1140
agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg 1200
acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac gtctatatca 1260
tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac aacatcgagg 1320
acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc gacggccccg 1380
tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa gaccccaacg 1440
agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc actctcggca 1500
tggacgagct gtacaagtaa gataatcaac ctctggatta caaaatttgt gaaagattga 1560
ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt 1620
tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt 1680
tagttcttgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc 1740
ggctgttggg cactgacaat tccgtgggtc gactgcttta tttgtgaaat ttgtgatgct 1800
attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt 1860
cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaacagc ggttcagcag 1920
aacataccct ccaccctcct ccaggaccac gagaaccagc gactctttga gatgcttgga 1980
cgaaaatgct tggtgagctg gggatctcct gcccccgccc cgtccccacc gtttcttcct 2040
cttcctctcc tccttctctc tcttcccctc ctcccgctcc tcctttccct ctccatcatc 2100
tcctctccta gaatttcccg tcataatcca cccttcccag gaagatctca atgtctactt 2160
gccttccctc tggctgcagc tcttcctttg ggcccatgac tgtcatgagg caggaaggac 2220
caggtctggc tccaagacct tgtggctacc cctgaccaga ctccactgac ccctgctttc 2280
ctctcccaga cgctggccac tgcagttgtt cagctgtacc tggcgctgcc ccctggagct 2340
gagcactgga ccaaggagca ttgtggggct gtgtgcttcg tgaaggataa cccccagaag 2400
tcctacttca tccgccttta cggccttcag gtgacccccc cacccccgac tggacttgca 2460
agccagttct caacccgcaa acccagatct gtgtccatat gtgtccatag cttcaagtct 2520
agagcatggc tacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct 2580
agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc 2640
aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcca 2700
gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga 2760
atggcgaatg gcgattccgt tgcaatggct ggcggtaata ttgttctgga tattaccagc 2820
aaggccgata gtttgagttc ttctactcag gcaagtgatg ttattactaa tcaaagaagt 2880
attgcgacaa cggttaattt gcgtgatgga cagactcttt tactcggtgg cctcactgat 2940
tataaaaaca cttctcagga ttctggcgta ccgttcctgt ctaaaatccc tttaatcggc 3000
ctcctgttta gctcccgctc tgattctaac gaggaaagca cgttatacgt gctcgtcaaa 3060
gcaaccatag tacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 3120
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 3180
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 3240
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 3300
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 3360
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 3420
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 3480
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttaaa tatttgctta 3540
tacaatcttc ctgtttttgg ggcttttctg attatcaacc ggggtacata tgattgacat 3600
gctagtttta cgattaccgt tcatcgattc tcttgtttgc tccagactct caggcaatga 3660
cctgatagcc tttgtagaga cctctcaaaa atagctaccc tctccggcat gaatttatca 3720
gctagaacgg ttgaatatca tattgatggt gatttgactg tctccggcct ttctcacccg 3780
tttgaatctt tacctacaca ttactcaggc attgcattta aaatatatga gggttctaaa 3840
aatttttatc cttgcgttga aataaaggct tctcccgcaa aagtattaca gggtcataat 3900
gtttttggta caaccgattt agctttatgc tctgaggctt tattgcttaa ttttgctaat 3960
tctttgcctt gcctgtatga tttattggat gttggaatcg cctgatgcgg tattttctcc 4020
ttacgcatct gtgcggtatt tcacaccgca tatggtgcac tctcagtaca atctgctctg 4080
atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg 4140
cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt 4200
gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc 4260
tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc 4320
ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc 4380
cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga 4440
gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt 4500
ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag 4560
tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag 4620
aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta 4680
ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg 4740
agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca 4800
gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag 4860
gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc 4920
gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg 4980
tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc 5040
ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg 5100
cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg 5160
gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga 5220
cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac 5280
tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa 5340
aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca 5400
aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag 5460
gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac 5520
cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa 5580
ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc 5640
accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag 5700
tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac 5760
cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc 5820
gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc 5880
ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca 5940
cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc 6000
tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg 6060
ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct 6120
ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata 6180
ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc 6240
gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatg             6289



<210> 41
<211> 7084
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAAV.ATG.coWAS (#1380)

<400> 41
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
taggctcgtc ttgaactcct gacctcaagt gatccactcg tctcggcctc ccaaagtgct 300
gggattacag gtgtgagcta ttgtccccag ccaaaaggaa aagttttact gtagtaaccc 360
ttccggacta gggacctcgg gcctcagcct caggctacct aggtgcttta gaaaggaggc 420
cacccaggcc catgactact ccttgccaca gggagccctg cacacagatg tgctaagctc 480
tcgctgccag ccagagggag gagggtctga gccagtcaga aggagatggg ccccagagag 540
taagaaaggg ggaggaggac ccaagctgat ccaaaaggtg ggtctaagca gtcaagtgga 600
ggagggttcc aatctgatgg cggagggccc aagctcagcc taacgaggag gccaggccca 660
ccaaggggcc cctggaggac ttgtttccct tgtcccttgt ggttttttgc atttcctgtt 720
cccttgctgc tcattgcgga agttcctctt cttaccctgc acccagagcc tcgccagaga 780
agacaagggc agaaagcacc atgggaggaa gacccggcgg ccgaggagcg ccagcagtgc 840
aacaaaacat tccgtcaacc ctgctgcagg accacgaaaa ccagaggctg tttgaaatgt 900
tgggacggaa gtgtctcact ctcgccacag ccgtcgtcca gctttatctt gcgcttcctc 960
ccggtgctga gcattggact aaagagcatt gcggcgcggt ctgttttgtc aaggataatc 1020
cccaaaaatc atatttcatt aggttgtacg gactccaagc tggacgcctt ctgtgggaac 1080
aagaactcta tagccagctc gtatatagca caccgacccc tttcttccat actttcgcgg 1140
gagacgactg tcaggcgggc ttgaactttg cggacgagga tgaagctcag gctttccgag 1200
cattggttca agaaaaaatc cagaaaagaa atcagcgaca gtccggagat cgccggcagc 1260
tgccgccgcc acctacaccg gccaatgagg aacggagggg aggccttccg ccacttccat 1320
tgcatccagg cggcgatcag ggtgggccac cagtagggcc cttgagtttg ggtctcgcta 1380
ctgtggatat acagaacccg gacataacat ctagccgcta ccgcggactg ccggctccag 1440
gtccgtcccc cgctgataaa aagcgctccg gcaaaaagaa gatatctaaa gcagatatcg 1500
gtgcgccctc cggtttcaag catgtctccc atgtaggatg ggacccgcaa aatggattcg 1560
acgttaataa cctcgatccg gacctgagga gtctcttctc tcgcgcgggt atcagcgagg 1620
cacagcttac tgatgccgaa acaagtaagt tgatatacga ctttatcgag gatcaaggag 1680
ggctggaagc ggtcaggcaa gaaatgcggc gacaagaacc tttgcccccg cccccgcccc 1740
cgtccagagg cgggaaccag cttccacgcc cacctatcgt tggagggaat aaaggcaggt 1800
ctgggccact ccctccggta ccgttgggga tcgctccacc gcctcctacg cctaggggac 1860
ccccgcctcc tggtcggggg ggaccgcccc ctccgccgcc tccagccact ggtcgaagtg 1920
gacccctccc gcctcctcca cccggcgccg ggggcccacc gatgccacct cctcctccgc 1980
ccccaccgcc tcccccttct tccggcaacg gtcccgcacc tccgcccctc cctccggcat 2040
tggtccccgc ggggggcctc gcgcctggtg gtggccgggg tgcacttctg gatcaaatcc 2100
gacagggcat acagttgaat aagacgcccg gcgcccctga aagctcagct ctgcaaccgc 2160
cgcctcagtc ctctgaaggg ttggtaggcg cgctcatgca tgtaatgcag aagcgcagtc 2220
gcgctatcca ctcatcagat gaaggtgaag accaggccgg tgacgaggac gaagacgatg 2280
aatgggacga ttgactgaac tgaactagtg tcgacgataa tcaacctctg gattacaaaa 2340
tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg 2400
ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct 2460
tgtataaatc ctggttagtt cttgccacgg cggaactcat cgccgcctgc cttgcccgct 2520
gctggacagg ggctcggctg ttgggcactg acaattccgt gggtcgactg ctttatttgt 2580
gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac 2640
aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa 2700
acagcggttc agcagaacat accctccacc ctcctccagg accacgagaa ccagcgactc 2760
tttgagatgc ttggacgaaa atgcttggtg agctggggat ctcctgcccc cgccccgtcc 2820
ccaccgtttc ttcctcttcc tctcctcctt ctctctcttc ccctcctccc gctcctcctt 2880
tccctctcca tcatctcctc tcctagaatt tcccgtcata atccaccctt cccaggaaga 2940
tctcaatgtc tacttgcctt ccctctggct gcagctcttc ctttgggccc atgactgtca 3000
tgaggcagga aggaccaggt ctggctccaa gaccttgtgg ctacccctga ccagactcca 3060
ctgacccctg ctttcctctc ccagacgctg gccactgcag ttgttcagct gtacctggcg 3120
ctgccccctg gagctgagca ctggaccaag gagcattgtg gggctgtgtg cttcgtgaag 3180
gataaccccc agaagtccta cttcatccgc ctttacggcc ttcaggtgac ccccccaccc 3240
ccgactggac ttgcaagcca gttctcaacc cgcaaaccca gatctgtgtc catatgtgtc 3300
catagcttca agtctagagc atggctacgt agataagtag catggcgggt taatcattaa 3360
ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac 3420
tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag 3480
cgagcgagcg cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac 3540
agttgcgcag cctgaatggc gaatggcgat tccgttgcaa tggctggcgg taatattgtt 3600
ctggatatta ccagcaaggc cgatagtttg agttcttcta ctcaggcaag tgatgttatt 3660
actaatcaaa gaagtattgc gacaacggtt aatttgcgtg atggacagac tcttttactc 3720
ggtggcctca ctgattataa aaacacttct caggattctg gcgtaccgtt cctgtctaaa 3780
atccctttaa tcggcctcct gtttagctcc cgctctgatt ctaacgagga aagcacgtta 3840
tacgtgctcg tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg 3900
tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt 3960
cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg 4020
ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga 4080
ttagggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac 4140
gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc 4200
tatctcggtc tattcttttg atttataagg gattttgccg atttcggcct attggttaaa 4260
aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat 4320
ttaaatattt gcttatacaa tcttcctgtt tttggggctt ttctgattat caaccggggt 4380
acatatgatt gacatgctag ttttacgatt accgttcatc gattctcttg tttgctccag 4440
actctcaggc aatgacctga tagcctttgt agagacctct caaaaatagc taccctctcc 4500
ggcatgaatt tatcagctag aacggttgaa tatcatattg atggtgattt gactgtctcc 4560
ggcctttctc acccgtttga atctttacct acacattact caggcattgc atttaaaata 4620
tatgagggtt ctaaaaattt ttatccttgc gttgaaataa aggcttctcc cgcaaaagta 4680
ttacagggtc ataatgtttt tggtacaacc gatttagctt tatgctctga ggctttattg 4740
cttaattttg ctaattcttt gccttgcctg tatgatttat tggatgttgg aatcgcctga 4800
tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg tgcactctca 4860
gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg 4920
acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct 4980
ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg 5040
gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt 5100
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac 5160
attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa 5220
aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat 5280
tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc 5340
agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga 5400
gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg 5460
cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc 5520
agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag 5580
taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc 5640
tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg 5700
taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg 5760
acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac 5820
ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac 5880
cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg 5940
agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg 6000
tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg 6060
agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac 6120
tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg 6180
ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg 6240
tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc 6300
aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc 6360
tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt 6420
agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc 6480
taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact 6540
caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac 6600
agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag 6660
aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg 6720
gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg 6780
tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga 6840
gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt 6900
ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct 6960
ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg 7020
aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt 7080
aatg                                                              7084


