                         SEQUENCE LISTING

<110>  The Regents of the University of Colorado, a body corporate
       Hodges, Robert S.
       Jiang, Ziqing
       Gera, Lajos
       Mant, Colin T.
 
<120>  ANTIMICROBIAL PEPTIDES AND METHODS OF TREATING GRAM-NEGATIVE 
       PATHOGENS: POLAR AND NON-POLAR FACE ANALOGS

<130>  2848-239-PCT

<140>  Not yet assigned
<141>  2018-04-19

<150>  62/487,361
<151>  2017-04-19

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide of Formula (I)


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X1 in Formula (I).  Xaa is selected from Ala, Ser, Thr, Lys, Arg,
       Orn, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X2 in Formula (I).  Xaa is selected from Ala, Ser, Lys, Arg, Orn,
       Dpr and Dbu

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X3 in Formula (I).  Xaa is selected from Ser, Lys, Arg, Orn, Dpr 
       and Dbu

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X4 in Formula (I).  Xaa is selected from Ala, Ser, Lys, Arg, Orn,
       Dpr and Dbu

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X5 in Formula (I).  Xaa is selected from Ser, Thr, Lys, Arg, Orn,
       Dpr and Dbu

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X6 in Formula (I).  Xaa is selected from Ala, Ser, Lys, Arg, Orn,
       Dpr and Dbu

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  X7 in Formula (I).  Xaa is selected from Ala, Lys, Arg, Orn, Dpr 
       and Dbu

<220>
<221>  VARIANT
<222>  (14)..(15)
<223>  X8 and X9 in Formula (I).  Xaa is selected from Ala, Ser, Lys, 
       Arg, Orn, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  X10 in Formula (I).  Xaa is selected from Ala, Lys, Arg, Orn, Dpr
       and Dbu

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  X11 in Formula (I).  Xaa is selected from Ala, Ser, Lys, Arg, 
       Orn, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  X12 in Formula (I).  Xaa is selected from Ala, Ser, Lys, Arg, 
       Orn, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (25)..(25)
<223>  X13 in Formula (I).  Xaa is selected from Ser, Lys, Arg, Orn, Dpr
       and Dbu

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  X14 in Formula (I).  Xaa is selected from Ala, Ser, Thr, Lys, 
       Arg, Orn, Dpr and Dbu

<400>  1

Xaa Leu Xaa Xaa Leu Leu Xaa Xaa Leu Ser Xaa Ala Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Leu Xaa Thr Leu Leu Xaa Ala Leu Xaa Xaa 
            20                  25      


<210>  2
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  2

Ala Leu Lys Ser Leu Leu Lys Thr Leu Ser Lys Ala Ala Ala Ala Ala 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  3
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  3

Ala Leu Lys Ser Leu Leu Lys Thr Leu Ser Ala Ala Ala Lys Lys Ala 
1               5                   10                  15      


Leu Ala Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  4
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  4

Ala Leu Lys Ser Leu Leu Ala Thr Leu Ser Lys Ala Ala Lys Lys Ala 
1               5                   10                  15      


Leu Lys Thr Leu Leu Ala Ala Leu Ser Lys 
            20                  25      


<210>  5
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  5

Ala Leu Ala Ser Leu Leu Lys Thr Leu Ser Lys Ala Ala Lys Lys Ala 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Ala 
            20                  25      


<210>  6
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  6

Ala Leu Lys Ser Leu Leu Lys Thr Leu Ser Lys Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  7
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Ala Leu Lys Ser Leu Leu Lys Thr Leu Ser Ala Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Ala Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  8
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  8

Ala Leu Lys Ser Leu Leu Ala Thr Leu Ser Lys Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Lys Thr Leu Leu Ala Ala Leu Ser Lys 
            20                  25      


<210>  9
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Ala Leu Ala Ser Leu Leu Lys Thr Leu Ser Lys Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Ala 
            20                  25      


<210>  10
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  10

Ala Leu Lys Lys Leu Leu Lys Thr Leu Ser Lys Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  11
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  11

Ala Leu Lys Ser Leu Leu Lys Lys Leu Ser Lys Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  12
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  12

Ala Leu Lys Ser Leu Leu Lys Thr Leu Ser Lys Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Lys Lys 
            20                  25      


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  13

Ala Leu Lys Lys Leu Leu Lys Thr Leu Ser Lys Ala Ala Ala Ala Ala 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  14
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  14

Ala Leu Lys Ser Leu Leu Lys Lys Leu Ser Lys Ala Ala Ala Ala Ala 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  15
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  15

Ala Leu Lys Ser Leu Leu Lys Thr Leu Ser Lys Ala Ala Ala Ala Ala 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Lys Lys 
            20                  25      


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  16

Glu Leu Glu Lys Gly Gly Leu Glu Gly Glu Lys Gly Gly Lys Glu Leu 
1               5                   10                  15      


Glu Lys 
        


<210>  17
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is selected from Lys, Arg, Orn, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Xaa is selected from Lys, Arg, Orn, Dpr and Dbu

<400>  17

Ala Leu Lys Lys Leu Leu Lys Thr Leu Ser Lys Ala Xaa Ala Ala Xaa 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  18
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  18

Ala Leu Lys Lys Leu Leu Lys Thr Leu Ser Lys Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  19
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Orn

<400>  19

Ala Leu Lys Lys Leu Leu Lys Thr Leu Ser Lys Ala Xaa Ala Ala Xaa 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  20
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Dbu

<400>  20

Ala Leu Lys Lys Leu Leu Lys Thr Leu Ser Lys Ala Xaa Ala Ala Xaa 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  21
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  21

Ala Leu Lys Lys Leu Leu Lys Thr Leu Ser Lys Ala Arg Ala Ala Arg 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  22
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Dpr

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Dpr

<400>  22

Ala Leu Lys Lys Leu Leu Lys Thr Leu Ser Lys Ala Xaa Ala Ala Xaa 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  23
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is selected from Lys, Arg, Orn, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is selected from Lys, Arg, Orn, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is selected from Lys, Arg, Orn, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa is selected from Lys, Arg, Orn, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Xaa is selected from Lys, Arg, Orn, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  Xaa is selected from Lys, Arg, Orn, Dpr and Dbu

<400>  23

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Xaa Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Xaa Thr Leu Leu Xaa Ala Leu Ser Xaa 
            20                  25      


<210>  24
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  24

Lys Leu Lys Ser Leu Leu Lys Thr Leu Ser Lys Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  25
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Orn

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Orn

<400>  25

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Xaa Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Xaa Thr Leu Leu Xaa Ala Leu Ser Xaa 
            20                  25      


<210>  26
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Dbu

<400>  26

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Xaa Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Xaa Thr Leu Leu Xaa Ala Leu Ser Xaa 
            20                  25      


<210>  27
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  27

Lys Leu Arg Ser Leu Leu Arg Thr Leu Ser Arg Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Arg Thr Leu Leu Arg Ala Leu Ser Arg 
            20                  25      


<210>  28
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Dpr

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Dpr

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Dpr

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Dpr

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Dpr

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Dpr

<400>  28

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Xaa Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Xaa Thr Leu Leu Xaa Ala Leu Ser Xaa 
            20                  25      


<210>  29
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is selected from Lys, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is selected from Lys, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (14)..(15)
<223>  Xaa is selected from Lys, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Xaa is selected from Lys, Dpr and Dbu

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  Xaa is selected from Lys, Dpr and Dbu

<400>  29

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Ala Ala Lys Xaa Xaa Lys 
1               5                   10                  15      


Leu Ala Thr Leu Leu Xaa Ala Leu Ser Xaa 
            20                  25      


<210>  30
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  30

Lys Leu Lys Ser Leu Leu Lys Thr Leu Ser Ala Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Ala Thr Leu Leu Lys Ala Leu Ser Lys 
            20                  25      


<210>  31
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (14)..(15)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Dbu

<400>  31

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Ala Ala Lys Xaa Xaa Lys 
1               5                   10                  15      


Leu Ala Thr Leu Leu Xaa Ala Leu Ser Xaa 
            20                  25      


<210>  32
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Dpr

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Dpr

<220>
<221>  MOD_RES
<222>  (14)..(15)
<223>  Dpr

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Dpr

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Dpr

<400>  32

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Ala Ala Lys Xaa Xaa Lys 
1               5                   10                  15      


Leu Ala Thr Leu Leu Xaa Ala Leu Ser Xaa 
            20                  25      


<210>  33
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is selected from Lys and Dbu

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is selected from Lys and Dbu

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is selected from Lys and Dbu

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa is selected from Lys and Dbu

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Xaa is selected from Lys and Dbu

<400>  33

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Xaa Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Xaa Thr Leu Leu Xaa Ala Leu Ser Ser 
            20                  25      


<210>  34
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  34

Lys Leu Lys Ser Leu Leu Lys Thr Leu Ser Lys Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Lys Thr Leu Leu Lys Ala Leu Ser Ser 
            20                  25      


<210>  35
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  Dbu

<400>  35

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Xaa Ala Lys Ala Ala Lys 
1               5                   10                  15      


Leu Xaa Thr Leu Leu Xaa Ala Leu Ser Ser 
            20                  25      


<210>  36
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is selected from Lys and Dbu

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is selected from Lys and Dbu

<220>
<221>  VARIANT
<222>  (14)..(15)
<223>  Xaa is selected from Lys and Dbu

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Xaa is selected from Lys and Dbu

<400>  36

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Ala Ala Lys Xaa Xaa Lys 
1               5                   10                  15      


Leu Ala Thr Leu Leu Xaa Ala Leu Ser Ser 
            20                  25      


<210>  37
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  37

Lys Leu Lys Ser Leu Leu Lys Thr Leu Ser Ala Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Ala Thr Leu Leu Lys Ala Leu Ser Ser 
            20                  25      


<210>  38
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Dbu

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Dbu

<400>  38

Lys Leu Xaa Ser Leu Leu Xaa Thr Leu Ser Ala Ala Lys Xaa Lys Leu 
1               5                   10                  15      


Ala Thr Leu Leu Xaa Ala Leu Ser Ser 
            20                  25  


