                         SEQUENCE LISTING

<110>  Bio-Path Holdings, Inc.
 
<120>  P-ETHOXY NUCLEIC ACIDS FOR BCL2 INHIBITION

<130>  BPHI.P0007WO

<140>  Unknown
<141>  2018-04-19

<150>  62/487,302
<151>  2017-04-19

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
cagcgtgcgc catccttccc                                                   20


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
gcgtgcgcca tccttccc                                                     18


<210>  3
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
tccttcc                                                                  7


<210>  4
<211>  6492
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (494)..(1213)

<400>  4
tttctgtgaa gcagaagtct gggaatcgat ctggaaatcc tcctaatttt tactccctct       60

ccccgcgact cctgattcat tgggaagttt caaatcagct ataactggag agtgctgaag      120

attgatggga tcgttgcctt atgcatttgt tttggtttta caaaaaggaa acttgacaga      180

ggatcatgct gtacttaaaa aatacaacat cacagaggaa gtagactgat attaacaata      240

cttactaata ataacgtgcc tcatgaaata aagatccgaa aggaattgga ataaaaattt      300

cctgcatctc atgccaaggg ggaaacacca gaatcaagtg ttccgcgtga ttgaagacac      360

cccctcgtcc aagaatgcaa agcacatcca ataaaatagc tggattataa ctcctcttct      420

ttctctgggg gccgtggggt gggagctggg gcgagaggtg ccgttggccc ccgttgcttt      480

tcctctggga agg atg gcg cac gct ggg aga aca ggg tac gat aac cgg         529
               Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg            
               1               5                   10                     

gag ata gtg atg aag tac atc cat tat aag ctg tcg cag agg ggc tac        577
Glu Ile Val Met Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr           
        15                  20                  25                        

gag tgg gat gcg gga gat gtg ggc gcc gcg ccc ccg ggg gcc gcc ccc        625
Glu Trp Asp Ala Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro           
    30                  35                  40                            

gca ccg ggc atc ttc tcc tcc cag ccc ggg cac acg ccc cat cca gcc        673
Ala Pro Gly Ile Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala           
45                  50                  55                  60            

gca tcc cgg gac ccg gtc gcc agg acc tcg ccg ctg cag acc ccg gct        721
Ala Ser Arg Asp Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala           
                65                  70                  75                

gcc ccc ggc gcc gcc gcg ggg cct gcg ctc agc ccg gtg cca cct gtg        769
Ala Pro Gly Ala Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val           
            80                  85                  90                    

gtc cac ctg acc ctc cgc cag gcc ggc gac gac ttc tcc cgc cgc tac        817
Val His Leu Thr Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr           
        95                  100                 105                       

cgc cgc gac ttc gcc gag atg tcc agc cag ctg cac ctg acg ccc ttc        865
Arg Arg Asp Phe Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe           
    110                 115                 120                           

acc gcg cgg gga cgc ttt gcc acg gtg gtg gag gag ctc ttc agg gac        913
Thr Ala Arg Gly Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp           
125                 130                 135                 140           

ggg gtg aac tgg ggg agg att gtg gcc ttc ttt gag ttc ggt ggg gtc        961
Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val           
                145                 150                 155               

atg tgt gtg gag agc gtc aac cgg gag atg tcg ccc ctg gtg gac aac       1009
Met Cys Val Glu Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn           
            160                 165                 170                   

atc gcc ctg tgg atg act gag tac ctg aac cgg cac ctg cac acc tgg       1057
Ile Ala Leu Trp Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp           
        175                 180                 185                       

atc cag gat aac gga ggc tgg gat gcc ttt gtg gaa ctg tac ggc ccc       1105
Ile Gln Asp Asn Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro           
    190                 195                 200                           

agc atg cgg cct ctg ttt gat ttc tcc tgg ctg tct ctg aag act ctg       1153
Ser Met Arg Pro Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu           
205                 210                 215                 220           

ctc agt ttg gcc ctg gtg gga gct tgc atc acc ctg ggt gcc tat ctg       1201
Leu Ser Leu Ala Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu           
                225                 230                 235               

ggc cac aag tga agtcaacatg cctgccccaa acaaatatgc aaaaggttca           1253
Gly His Lys                                                               
                                                                          

ctaaagcagt agaaataata tgcattgtca gtgatgtacc atgaaacaaa gctgcaggct     1313

gtttaagaaa aaataacaca catataaaca tcacacacac agacagacac acacacacac     1373

aacaattaac agtcttcagg caaaacgtcg aatcagctat ttactgccaa agggaaatat     1433

catttatttt ttacattatt aagaaaaaaa gatttattta tttaagacag tcccatcaaa     1493

actcctgtct ttggaaatcc gaccactaat tgccaagcac cgcttcgtgt ggctccacct     1553

ggatgttctg tgcctgtaaa catagattcg ctttccatgt tgttggccgg atcaccatct     1613

gaagagcaga cggatggaaa aaggacctga tcattgggga agctggcttt ctggctgctg     1673

gaggctgggg agaaggtgtt cattcacttg catttctttg ccctgggggc tgtgatatta     1733

acagagggag ggttcctgtg gggggaagtc catgcctccc tggcctgaag aagagactct     1793

ttgcatatga ctcacatgat gcatacctgg tgggaggaaa agagttggga acttcagatg     1853

gacctagtac ccactgagat ttccacgccg aaggacagcg atgggaaaaa tgcccttaaa     1913

tcataggaaa gtattttttt aagctaccaa ttgtgccgag aaaagcattt tagcaattta     1973

tacaatatca tccagtacct taagccctga ttgtgtatat tcatatattt tggatacgca     2033

ccccccaact cccaatactg gctctgtctg agtaagaaac agaatcctct ggaacttgag     2093

gaagtgaaca tttcggtgac ttccgcatca ggaaggctag agttacccag agcatcaggc     2153

cgccacaagt gcctgctttt aggagaccga agtccgcaga acctgcctgt gtcccagctt     2213

ggaggcctgg tcctggaact gagccggggc cctcactggc ctcctccagg gatgatcaac     2273

agggcagtgt ggtctccgaa tgtctggaag ctgatggagc tcagaattcc actgtcaaga     2333

aagagcagta gaggggtgtg gctgggcctg tcaccctggg gccctccagg taggcccgtt     2393

ttcacgtgga gcatgggagc cacgaccctt cttaagacat gtatcactgt agagggaagg     2453

aacagaggcc ctgggccctt cctatcagaa ggacatggtg aaggctggga acgtgaggag     2513

aggcaatggc cacggcccat tttggctgta gcacatggca cgttggctgt gtggccttgg     2573

cccacctgtg agtttaaagc aaggctttaa atgactttgg agagggtcac aaatcctaaa     2633

agaagcattg aagtgaggtg tcatggatta attgacccct gtctatggaa ttacatgtaa     2693

aacattatct tgtcactgta gtttggtttt atttgaaaac ctgacaaaaa aaaagttcca     2753

ggtgtggaat atgggggtta tctgtacatc ctggggcatt aaaaaaaaaa tcaatggtgg     2813

ggaactataa agaagtaaca aaagaagtga catcttcagc aaataaacta ggaaattttt     2873

ttttcttcca gtttagaatc agccttgaaa cattgatgga ataactctgt ggcattattg     2933

cattatatac catttatctg tattaacttt ggaatgtact ctgttcaatg tttaatgctg     2993

tggttgatat ttcgaaagct gctttaaaaa aatacatgca tctcagcgtt tttttgtttt     3053

taattgtatt tagttatggc ctatacacta tttgtgagca aaggtgatcg ttttctgttt     3113

gagattttta tctcttgatt cttcaaaagc attctgagaa ggtgagataa gccctgagtc     3173

tcagctacct aagaaaaacc tggatgtcac tggccactga ggagctttgt ttcaaccaag     3233

tcatgtgcat ttccacgtca acagaattgt ttattgtgac agttatatct gttgtccctt     3293

tgaccttgtt tcttgaaggt ttcctcgtcc ctgggcaatt ccgcatttaa ttcatggtat     3353

tcaggattac atgcatgttt ggttaaaccc atgagattca ttcagttaaa aatccagatg     3413

gcaaatgacc agcagattca aatctatggt ggtttgacct ttagagagtt gctttacgtg     3473

gcctgtttca acacagaccc acccagagcc ctcctgccct ccttccgcgg gggctttctc     3533

atggctgtcc ttcagggtct tcctgaaatg cagtggtgct tacgctccac caagaaagca     3593

ggaaacctgt ggtatgaagc cagacctccc cggcgggcct cagggaacag aatgatcaga     3653

cctttgaatg attctaattt ttaagcaaaa tattatttta tgaaaggttt acattgtcaa     3713

agtgatgaat atggaatatc caatcctgtg ctgctatcct gccaaaatca ttttaatgga     3773

gtcagtttgc agtatgctcc acgtggtaag atcctccaag ctgctttaga agtaacaatg     3833

aagaacgtgg acgtttttaa tataaagcct gttttgtctt ttgttgttgt tcaaacggga     3893

ttcacagagt atttgaaaaa tgtatatata ttaagaggtc acgggggcta attgctggct     3953

ggctgccttt tgctgtgggg ttttgttacc tggttttaat aacagtaaat gtgcccagcc     4013

tcttggcccc agaactgtac agtattgtgg ctgcacttgc tctaagagta gttgatgttg     4073

cattttcctt attgttaaaa acatgttaga agcaatgaat gtatataaaa gcctcaacta     4133

gtcatttttt tctcctcttc ttttttttca ttatatctaa ttattttgca gttgggcaac     4193

agagaaccat ccctattttg tattgaagag ggattcacat ctgcatctta actgctcttt     4253

atgaatgaaa aaacagtcct ctgtatgtac tcctctttac actggccagg gtcagagtta     4313

aatagagtat atgcactttc caaattgggg acaagggctc taaaaaaagc cccaaaagga     4373

gaagaacatc tgagaacctc ctcggccctc ccagtccctc gctgcacaaa tactccgcaa     4433

gagaggccag aatgacagct gacagggtct atggccatcg ggtcgtctcc gaagatttgg     4493

caggggcaga aaactctggc aggcttaaga tttggaataa agtcacagaa ttaaggaagc     4553

acctcaattt agttcaaaca agacgccaac attctctcca cagctcactt acctctctgt     4613

gttcagatgt ggccttccat ttatatgtga tctttgtttt attagtaaat gcttatcatc     4673

taaagatgta gctctggccc agtgggaaaa attaggaagt gattataaat cgagaggagt     4733

tataataatc aagattaaat gtaaataatc agggcaatcc caacacatgt ctagctttca     4793

cctccaggat ctattgagtg aacagaattg caaatagtct ctatttgtaa ttgaacttat     4853

cctaaaacaa atagtttata aatgtgaact taaactctaa ttaattccaa ctgtactttt     4913

aaggcagtgg ctgtttttag actttcttat cacttatagt tagtaatgta cacctactct     4973

atcagagaaa aacaggaaag gctcgaaata caagccattc taaggaaatt agggagtcag     5033

ttgaaattct attctgatct tattctgtgg tgtcttttgc agcccagaca aatgtggtta     5093

cacacttttt aagaaataca attctacatt gtcaagctta tgaaggttcc aatcagatct     5153

ttattgttat tcaatttgga tctttcaggg attttttttt taaattatta tgggacaaag     5213

gacatttgtt ggaggggtgg gagggaggaa gaatttttaa atgtaaaaca ttcccaagtt     5273

tggatcaggg agttggaagt tttcagaata accagaacta agggtatgaa ggacctgtat     5333

tggggtcgat gtgatgcctc tgcgaagaac cttgtgtgac aaatgagaaa cattttgaag     5393

tttgtggtac gacctttaga ttccagagac atcagcatgg ctcaaagtgc agctccgttt     5453

ggcagtgcaa tggtataaat ttcaagctgg atatgtctaa tgggtattta aacaataaat     5513

gtgcagtttt aactaacagg atatttaatg acaaccttct ggttggtagg gacatctgtt     5573

tctaaatgtt tattatgtac aatacagaaa aaaattttat aaaattaagc aatgtgaaac     5633

tgaattggag agtgataata caagtccttt agtcttaccc agtgaatcat tctgttccat     5693

gtctttggac aaccatgacc ttggacaatc atgaaatatg catctcactg gatgcaaaga     5753

aaatcagatg gagcatgaat ggtactgtac cggttcatct ggactgcccc agaaaaataa     5813

cttcaagcaa acatcctatc aacaacaagg ttgttctgca taccaagctg agcacagaag     5873

atgggaacac tggtggagga tggaaaggct cgctcaatca agaaaattct gagactatta     5933

ataaataaga ctgtagtgta gatactgagt aaatccatgc acctaaacct tttggaaaat     5993

ctgccgtggg ccctccagat agctcatttc attaagtttt tccctccaag gtagaatttg     6053

caagagtgac agtggattgc atttcttttg gggaagcttt cttttggtgg ttttgtttat     6113

tataccttct taagttttca accaaggttt gcttttgttt tgagttactg gggttatttt     6173

tgttttaaat aaaaataagt gtacaataag tgtttttgta ttgaaagctt ttgttatcaa     6233

gattttcata cttttacctt ccatggctct ttttaagatt gatactttta agaggtggct     6293

gatattctgc aacactgtac acataaaaaa tacggtaagg atactttaca tggttaaggt     6353

aaagtaagtc tccagttggc caccattagc tataatggca ctttgtttgt gttgttggaa     6413

aaagtcacat tgccattaaa ctttccttgt ctgtctagtt aatattgtga agaaaaataa     6473

agtacagtgt gagatactg                                                  6492


<210>  5
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  6
<211>  1207
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (494)..(1111)

<400>  6
tttctgtgaa gcagaagtct gggaatcgat ctggaaatcc tcctaatttt tactccctct       60

ccccgcgact cctgattcat tgggaagttt caaatcagct ataactggag agtgctgaag      120

attgatggga tcgttgcctt atgcatttgt tttggtttta caaaaaggaa acttgacaga      180

ggatcatgct gtacttaaaa aatacaacat cacagaggaa gtagactgat attaacaata      240

cttactaata ataacgtgcc tcatgaaata aagatccgaa aggaattgga ataaaaattt      300

cctgcatctc atgccaaggg ggaaacacca gaatcaagtg ttccgcgtga ttgaagacac      360

cccctcgtcc aagaatgcaa agcacatcca ataaaatagc tggattataa ctcctcttct      420

ttctctgggg gccgtggggt gggagctggg gcgagaggtg ccgttggccc ccgttgcttt      480

tcctctggga agg atg gcg cac gct ggg aga aca ggg tac gat aac cgg         529
               Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg            
               1               5                   10                     

gag ata gtg atg aag tac atc cat tat aag ctg tcg cag agg ggc tac        577
Glu Ile Val Met Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr           
        15                  20                  25                        

gag tgg gat gcg gga gat gtg ggc gcc gcg ccc ccg ggg gcc gcc ccc        625
Glu Trp Asp Ala Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro           
    30                  35                  40                            

gca ccg ggc atc ttc tcc tcc cag ccc ggg cac acg ccc cat cca gcc        673
Ala Pro Gly Ile Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala           
45                  50                  55                  60            

gca tcc cgg gac ccg gtc gcc agg acc tcg ccg ctg cag acc ccg gct        721
Ala Ser Arg Asp Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala           
                65                  70                  75                

gcc ccc ggc gcc gcc gcg ggg cct gcg ctc agc ccg gtg cca cct gtg        769
Ala Pro Gly Ala Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val           
            80                  85                  90                    

gtc cac ctg acc ctc cgc cag gcc ggc gac gac ttc tcc cgc cgc tac        817
Val His Leu Thr Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr           
        95                  100                 105                       

cgc cgc gac ttc gcc gag atg tcc agc cag ctg cac ctg acg ccc ttc        865
Arg Arg Asp Phe Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe           
    110                 115                 120                           

acc gcg cgg gga cgc ttt gcc acg gtg gtg gag gag ctc ttc agg gac        913
Thr Ala Arg Gly Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp           
125                 130                 135                 140           

ggg gtg aac tgg ggg agg att gtg gcc ttc ttt gag ttc ggt ggg gtc        961
Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val           
                145                 150                 155               

atg tgt gtg gag agc gtc aac cgg gag atg tcg ccc ctg gtg gac aac       1009
Met Cys Val Glu Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn           
            160                 165                 170                   

atc gcc ctg tgg atg act gag tac ctg aac cgg cac ctg cac acc tgg       1057
Ile Ala Leu Trp Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp           
        175                 180                 185                       

atc cag gat aac gga ggc tgg gta ggt gca ctt ggt gat gtg agt ctg       1105
Ile Gln Asp Asn Gly Gly Trp Val Gly Ala Leu Gly Asp Val Ser Leu           
    190                 195                 200                           

ggc tga ggccacaggt ccgagatgcg ggggttggag tgcgggtggg ctcctggggc        1161
Gly                                                                       
205                                                                       

aatgggaggc tgtggagccg gcgaaataaa atcagagttg ttgcta                    1207


<210>  7
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Val Gly Ala Leu Gly Asp Val Ser Leu Gly 
        195                 200                 205 


