                         SEQUENCE LISTING

<110>  Bio-Path Holdings, Inc.
 
<120>  P-ETHOXY NUCLEIC ACIDS FOR IGF-1R INHIBITION

<130>  BPHI.P0006WO

<140>  Unknown
>141>  2018-04-19

<150>  62/487,420
<151>  2017-04-19

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
tcctccggag ccagactt                                                     18


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
ggaccctcct ccggagcc                                                     18


<210>  3
<211>  12262
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1044)..(5147)

<400>  3
agtgtgtggc agcggcggcg gcggcgcggc gaggctgggg ctcttgttta ccagcattaa       60

ctccgctgag cggaaaaaaa aagggaaaaa acccgaggag gagcgagcgc accaggcgaa      120

ctcgagagag gcgggagagc gagagggacg ccgccagcga gcctgcccac ggccggcgct      180

cgcagaccct cggccccgct ccccggatcc ccccgcgccc tccacgcccc tcccgcgcgg      240

gggcagctcc acggcgcgcc tcgcctcggc tgtgaccttc agcgagccgg agcccccgcg      300

cagagcaggc ggcggcgggc gggggccggg cgggggccgg cgcggggcgg gcggcggcgc      360

agagccgggc ggcgcggcgg gagtgctgag cgcggcgcgg ccggcccgcc gctttgtgtg      420

tgtcctggat ttgggaagga gctcgccgcg gcggcggcgg cgctgaggga ggaggcggcg      480

gcgagcggag ccaggaggag gaggaggagg gggagccgct cattcatttt gactccgcgt      540

ttctgcccct cgccggcctc gcctgtgacc cggacttcgg ggcgatcttg cgaactgcgt      600

cgcgccctcc cgcggcggaa gctcgggcgt ccggccgcct cccgcgcggc cagggccggg      660

cttgtttttc ctcgcctagg cagatttggg ctttgccccc tttctttgca gttttccccc      720

cttcctgcct ctccgggttt gaaaatggag gccgacgacg ccgacagccc gccccggcgc      780

gcctcgggtt cccgactccg ccgagccctg ggccgctgct gccggcgctg aggggccgcc      840

ccgcgccgcc cgccccgtcc gcgcacccgg agggccccgg cggcgccgcc ttcggagtat      900

tgtttccttc gcccttgttt ttggaggggg agcgaagact gagtttgaga cttgtttcct      960

ttcatttcct ttttttcttt tcttttcttt tttttttttt tttttttttt tgagaaaggg     1020

gaatttcatc ccaaataaaa gga atg aag tct ggc tcc gga gga ggg tcc ccg     1073
                          Met Lys Ser Gly Ser Gly Gly Gly Ser Pro         
                          1               5                   10          

acc tcg ctg tgg ggg ctc ctg ttt ctc tcc gcc gcg ctc tcg ctc tgg       1121
Thr Ser Leu Trp Gly Leu Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp           
                15                  20                  25                

ccg acg agt gga gaa atc tgc ggg cca ggc atc gac atc cgc aac gac       1169
Pro Thr Ser Gly Glu Ile Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp           
            30                  35                  40                    

tat cag cag ctg aag cgc ctg gag aac tgc acg gtg atc gag ggc tac       1217
Tyr Gln Gln Leu Lys Arg Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr           
        45                  50                  55                        

ctc cac atc ctg ctc atc tcc aag gcc gag gac tac cgc agc tac cgc       1265
Leu His Ile Leu Leu Ile Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg           
    60                  65                  70                            

ttc ccc aag ctc acg gtc att acc gag tac ttg ctg ctg ttc cga gtg       1313
Phe Pro Lys Leu Thr Val Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val           
75                  80                  85                  90            

gct ggc ctc gag agc ctc gga gac ctc ttc ccc aac ctc acg gtc atc       1361
Ala Gly Leu Glu Ser Leu Gly Asp Leu Phe Pro Asn Leu Thr Val Ile           
                95                  100                 105               

cgc ggc tgg aaa ctc ttc tac aac tac gcc ctg gtc atc ttc gag atg       1409
Arg Gly Trp Lys Leu Phe Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met           
            110                 115                 120                   

acc aat ctc aag gat att ggg ctt tac aac ctg agg aac att act cgg       1457
Thr Asn Leu Lys Asp Ile Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg           
        125                 130                 135                       

ggg gcc atc agg att gag aaa aat gct gac ctc tgt tac ctc tcc act       1505
Gly Ala Ile Arg Ile Glu Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr           
    140                 145                 150                           

gtg gac tgg tcc ctg atc ctg gat gcg gtg tcc aat aac tac att gtg       1553
Val Asp Trp Ser Leu Ile Leu Asp Ala Val Ser Asn Asn Tyr Ile Val           
155                 160                 165                 170           

ggg aat aag ccc cca aag gaa tgt ggg gac ctg tgt cca ggg acc atg       1601
Gly Asn Lys Pro Pro Lys Glu Cys Gly Asp Leu Cys Pro Gly Thr Met           
                175                 180                 185               

gag gag aag ccg atg tgt gag aag acc acc atc aac aat gag tac aac       1649
Glu Glu Lys Pro Met Cys Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn           
            190                 195                 200                   

tac cgc tgc tgg acc aca aac cgc tgc cag aaa atg tgc cca agc acg       1697
Tyr Arg Cys Trp Thr Thr Asn Arg Cys Gln Lys Met Cys Pro Ser Thr           
        205                 210                 215                       

tgt ggg aag cgg gcg tgc acc gag aac aat gag tgc tgc cac ccc gag       1745
Cys Gly Lys Arg Ala Cys Thr Glu Asn Asn Glu Cys Cys His Pro Glu           
    220                 225                 230                           

tgc ctg ggc agc tgc agc gcg cct gac aac gac acg gcc tgt gta gct       1793
Cys Leu Gly Ser Cys Ser Ala Pro Asp Asn Asp Thr Ala Cys Val Ala           
235                 240                 245                 250           

tgc cgc cac tac tac tat gcc ggt gtc tgt gtg cct gcc tgc ccg ccc       1841
Cys Arg His Tyr Tyr Tyr Ala Gly Val Cys Val Pro Ala Cys Pro Pro           
                255                 260                 265               

aac acc tac agg ttt gag ggc tgg cgc tgt gtg gac cgt gac ttc tgc       1889
Asn Thr Tyr Arg Phe Glu Gly Trp Arg Cys Val Asp Arg Asp Phe Cys           
            270                 275                 280                   

gcc aac atc ctc agc gcc gag agc agc gac tcc gag ggg ttt gtg atc       1937
Ala Asn Ile Leu Ser Ala Glu Ser Ser Asp Ser Glu Gly Phe Val Ile           
        285                 290                 295                       

cac gac ggc gag tgc atg cag gag tgc ccc tcg ggc ttc atc cgc aac       1985
His Asp Gly Glu Cys Met Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn           
    300                 305                 310                           

ggc agc cag agc atg tac tgc atc cct tgt gaa ggt cct tgc ccg aag       2033
Gly Ser Gln Ser Met Tyr Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys           
315                 320                 325                 330           

gtc tgt gag gaa gaa aag aaa aca aag acc att gat tct gtt act tct       2081
Val Cys Glu Glu Glu Lys Lys Thr Lys Thr Ile Asp Ser Val Thr Ser           
                335                 340                 345               

gct cag atg ctc caa gga tgc acc atc ttc aag ggc aat ttg ctc att       2129
Ala Gln Met Leu Gln Gly Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile           
            350                 355                 360                   

aac atc cga cgg ggg aat aac att gct tca gag ctg gag aac ttc atg       2177
Asn Ile Arg Arg Gly Asn Asn Ile Ala Ser Glu Leu Glu Asn Phe Met           
        365                 370                 375                       

ggg ctc atc gag gtg gtg acg ggc tac gtg aag atc cgc cat tct cat       2225
Gly Leu Ile Glu Val Val Thr Gly Tyr Val Lys Ile Arg His Ser His           
    380                 385                 390                           

gcc ttg gtc tcc ttg tcc ttc cta aaa aac ctt cgc ctc atc cta gga       2273
Ala Leu Val Ser Leu Ser Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly           
395                 400                 405                 410           

gag gag cag cta gaa ggg aat tac tcc ttc tac gtc ctc gac aac cag       2321
Glu Glu Gln Leu Glu Gly Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln           
                415                 420                 425               

aac ttg cag caa ctg tgg gac tgg gac cac cgc aac ctg acc atc aaa       2369
Asn Leu Gln Gln Leu Trp Asp Trp Asp His Arg Asn Leu Thr Ile Lys           
            430                 435                 440                   

gca ggg aaa atg tac ttt gct ttc aat ccc aaa tta tgt gtt tcc gaa       2417
Ala Gly Lys Met Tyr Phe Ala Phe Asn Pro Lys Leu Cys Val Ser Glu           
        445                 450                 455                       

att tac cgc atg gag gaa gtg acg ggg act aaa ggg cgc caa agc aaa       2465
Ile Tyr Arg Met Glu Glu Val Thr Gly Thr Lys Gly Arg Gln Ser Lys           
    460                 465                 470                           

ggg gac ata aac acc agg aac aac ggg gag aga gcc tcc tgt gaa agt       2513
Gly Asp Ile Asn Thr Arg Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser           
475                 480                 485                 490           

gac gtc ctg cat ttc acc tcc acc acc acg tcg aag aat cgc atc atc       2561
Asp Val Leu His Phe Thr Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile           
                495                 500                 505               

ata acc tgg cac cgg tac cgg ccc cct gac tac agg gat ctc atc agc       2609
Ile Thr Trp His Arg Tyr Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser           
            510                 515                 520                   

ttc acc gtt tac tac aag gaa gca ccc ttt aag aat gtc aca gag tat       2657
Phe Thr Val Tyr Tyr Lys Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr           
        525                 530                 535                       

gat ggg cag gat gcc tgc ggc tcc aac agc tgg aac atg gtg gac gtg       2705
Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Asn Met Val Asp Val           
    540                 545                 550                           

gac ctc ccg ccc aac aag gac gtg gag ccc ggc atc tta cta cat ggg       2753
Asp Leu Pro Pro Asn Lys Asp Val Glu Pro Gly Ile Leu Leu His Gly           
555                 560                 565                 570           

ctg aag ccc tgg act cag tac gcc gtt tac gtc aag gct gtg acc ctc       2801
Leu Lys Pro Trp Thr Gln Tyr Ala Val Tyr Val Lys Ala Val Thr Leu           
                575                 580                 585               

acc atg gtg gag aac gac cat atc cgt ggg gcc aag agt gag atc ttg       2849
Thr Met Val Glu Asn Asp His Ile Arg Gly Ala Lys Ser Glu Ile Leu           
            590                 595                 600                   

tac att cgc acc aat gct tca gtt cct tcc att ccc ttg gac gtt ctt       2897
Tyr Ile Arg Thr Asn Ala Ser Val Pro Ser Ile Pro Leu Asp Val Leu           
        605                 610                 615                       

tca gca tcg aac tcc tct tct cag tta atc gtg aag tgg aac cct ccc       2945
Ser Ala Ser Asn Ser Ser Ser Gln Leu Ile Val Lys Trp Asn Pro Pro           
    620                 625                 630                           

tct ctg ccc aac ggc aac ctg agt tac tac att gtg cgc tgg cag cgg       2993
Ser Leu Pro Asn Gly Asn Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg           
635                 640                 645                 650           

cag cct cag gac ggc tac ctt tac cgg cac aat tac tgc tcc aaa gac       3041
Gln Pro Gln Asp Gly Tyr Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp           
                655                 660                 665               

aaa atc ccc atc agg aag tat gcc gac ggc acc atc gac att gag gag       3089
Lys Ile Pro Ile Arg Lys Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu           
            670                 675                 680                   

gtc aca gag aac ccc aag act gag gtg tgt ggt ggg gag aaa ggg cct       3137
Val Thr Glu Asn Pro Lys Thr Glu Val Cys Gly Gly Glu Lys Gly Pro           
        685                 690                 695                       

tgc tgc gcc tgc ccc aaa act gaa gcc gag aag cag gcc gag aag gag       3185
Cys Cys Ala Cys Pro Lys Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu           
    700                 705                 710                           

gag gct gaa tac cgc aaa gtc ttt gag aat ttc ctg cac aac tcc atc       3233
Glu Ala Glu Tyr Arg Lys Val Phe Glu Asn Phe Leu His Asn Ser Ile           
715                 720                 725                 730           

ttc gtg ccc aga cct gaa agg aag cgg aga gat gtc atg caa gtg gcc       3281
Phe Val Pro Arg Pro Glu Arg Lys Arg Arg Asp Val Met Gln Val Ala           
                735                 740                 745               

aac acc acc atg tcc agc cga agc agg aac acc acg gcc gca gac acc       3329
Asn Thr Thr Met Ser Ser Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr           
            750                 755                 760                   

tac aac atc acc gac ccg gaa gag ctg gag aca gag tac cct ttc ttt       3377
Tyr Asn Ile Thr Asp Pro Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe           
        765                 770                 775                       

gag agc aga gtg gat aac aag gag aga act gtc att tct aac ctt cgg       3425
Glu Ser Arg Val Asp Asn Lys Glu Arg Thr Val Ile Ser Asn Leu Arg           
    780                 785                 790                           

cct ttc aca ttg tac cgc atc gat atc cac agc tgc aac cac gag gct       3473
Pro Phe Thr Leu Tyr Arg Ile Asp Ile His Ser Cys Asn His Glu Ala           
795                 800                 805                 810           

gag aag ctg ggc tgc agc gcc tcc aac ttc gtc ttt gca agg act atg       3521
Glu Lys Leu Gly Cys Ser Ala Ser Asn Phe Val Phe Ala Arg Thr Met           
                815                 820                 825               

ccc gca gaa gga gca gat gac att cct ggg cca gtg acc tgg gag cca       3569
Pro Ala Glu Gly Ala Asp Asp Ile Pro Gly Pro Val Thr Trp Glu Pro           
            830                 835                 840                   

agg cct gaa aac tcc atc ttt tta aag tgg ccg gaa cct gag aat ccc       3617
Arg Pro Glu Asn Ser Ile Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro           
        845                 850                 855                       

aat gga ttg att cta atg tat gaa ata aaa tac gga tca caa gtt gag       3665
Asn Gly Leu Ile Leu Met Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu           
    860                 865                 870                           

gat cag cga gaa tgt gtg tcc aga cag gaa tac agg aag tat gga ggg       3713
Asp Gln Arg Glu Cys Val Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly           
875                 880                 885                 890           

gcc aag cta aac cgg cta aac ccg ggg aac tac aca gcc cgg att cag       3761
Ala Lys Leu Asn Arg Leu Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln           
                895                 900                 905               

gcc aca tct ctc tct ggg aat ggg tcg tgg aca gat cct gtg ttc ttc       3809
Ala Thr Ser Leu Ser Gly Asn Gly Ser Trp Thr Asp Pro Val Phe Phe           
            910                 915                 920                   

tat gtc cag gcc aaa aca gga tat gaa aac ttc atc cat ctg atc atc       3857
Tyr Val Gln Ala Lys Thr Gly Tyr Glu Asn Phe Ile His Leu Ile Ile           
        925                 930                 935                       

gct ctg ccc gtc gct gtc ctg ttg atc gtg gga ggg ttg gtg att atg       3905
Ala Leu Pro Val Ala Val Leu Leu Ile Val Gly Gly Leu Val Ile Met           
    940                 945                 950                           

ctg tac gtc ttc cat aga aag aga aat aac agc agg ctg ggg aat gga       3953
Leu Tyr Val Phe His Arg Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly           
955                 960                 965                 970           

gtg ctg tat gcc tct gtg aac ccg gag tac ttc agc gct gct gat gtg       4001
Val Leu Tyr Ala Ser Val Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val           
                975                 980                 985               

tac gtt cct gat gag tgg gag gtg gct cgg gag aag atc acc  atg agc      4049
Tyr Val Pro Asp Glu Trp Glu Val Ala Arg Glu Lys Ile Thr  Met Ser          
            990                 995                 1000                  

cgg gaa ctt  ggg cag ggg tcg ttt  ggg atg gtc tat gaa  gga gtt        4094
Arg Glu Leu  Gly Gln Gly Ser Phe  Gly Met Val Tyr Glu  Gly Val            
        1005                 1010                 1015                    

gcc aag ggt  gtg gtg aaa gat gaa  cct gaa acc aga gtg  gcc att        4139
Ala Lys Gly  Val Val Lys Asp Glu  Pro Glu Thr Arg Val  Ala Ile            
        1020                 1025                 1030                    

aaa aca gtg  aac gag gcc gca agc  atg cgt gag agg att  gag ttt        4184
Lys Thr Val  Asn Glu Ala Ala Ser  Met Arg Glu Arg Ile  Glu Phe            
        1035                 1040                 1045                    

ctc aac gaa  gct tct gtg atg aag  gag ttc aat tgt cac  cat gtg        4229
Leu Asn Glu  Ala Ser Val Met Lys  Glu Phe Asn Cys His  His Val            
        1050                 1055                 1060                    

gtg cga ttg  ctg ggt gtg gtg tcc  caa ggc cag cca aca  ctg gtc        4274
Val Arg Leu  Leu Gly Val Val Ser  Gln Gly Gln Pro Thr  Leu Val            
        1065                 1070                 1075                    

atc atg gaa  ctg atg aca cgg ggc  gat ctc aaa agt tat  ctc cgg        4319
Ile Met Glu  Leu Met Thr Arg Gly  Asp Leu Lys Ser Tyr  Leu Arg            
        1080                 1085                 1090                    

tct ctg agg  cca gaa atg gag aat  aat cca gtc cta gca  cct cca        4364
Ser Leu Arg  Pro Glu Met Glu Asn  Asn Pro Val Leu Ala  Pro Pro            
        1095                 1100                 1105                    

agc ctg agc  aag atg att cag atg  gcc gga gag att gca  gac ggc        4409
Ser Leu Ser  Lys Met Ile Gln Met  Ala Gly Glu Ile Ala  Asp Gly            
        1110                 1115                 1120                    

atg gca tac  ctc aac gcc aat aag  ttc gtc cac aga gac  ctt gct        4454
Met Ala Tyr  Leu Asn Ala Asn Lys  Phe Val His Arg Asp  Leu Ala            
        1125                 1130                 1135                    

gcc cgg aat  tgc atg gta gcc gaa  gat ttc aca gtc aaa  atc gga        4499
Ala Arg Asn  Cys Met Val Ala Glu  Asp Phe Thr Val Lys  Ile Gly            
        1140                 1145                 1150                    

gat ttt ggt  atg acg cga gat atc  tat gag aca gac tat  tac cgg        4544
Asp Phe Gly  Met Thr Arg Asp Ile  Tyr Glu Thr Asp Tyr  Tyr Arg            
        1155                 1160                 1165                    

aaa gga ggg  aaa ggg ctg ctg ccc  gtg cgc tgg atg tct  cct gag        4589
Lys Gly Gly  Lys Gly Leu Leu Pro  Val Arg Trp Met Ser  Pro Glu            
        1170                 1175                 1180                    

tcc ctc aag  gat gga gtc ttc acc  act tac tcg gac gtc  tgg tcc        4634
Ser Leu Lys  Asp Gly Val Phe Thr  Thr Tyr Ser Asp Val  Trp Ser            
        1185                 1190                 1195                    

ttc ggg gtc  gtc ctc tgg gag atc  gcc aca ctg gcc gag  cag ccc        4679
Phe Gly Val  Val Leu Trp Glu Ile  Ala Thr Leu Ala Glu  Gln Pro            
        1200                 1205                 1210                    

tac cag ggc  ttg tcc aac gag caa  gtc ctt cgc ttc gtc  atg gag        4724
Tyr Gln Gly  Leu Ser Asn Glu Gln  Val Leu Arg Phe Val  Met Glu            
        1215                 1220                 1225                    

ggc ggc ctt  ctg gac aag cca gac  aac tgt cct gac atg  ctg ttt        4769
Gly Gly Leu  Leu Asp Lys Pro Asp  Asn Cys Pro Asp Met  Leu Phe            
        1230                 1235                 1240                    

gaa ctg atg  cgc atg tgc tgg cag  tat aac ccc aag atg  agg cct        4814
Glu Leu Met  Arg Met Cys Trp Gln  Tyr Asn Pro Lys Met  Arg Pro            
        1245                 1250                 1255                    

tcc ttc ctg  gag atc atc agc agc  atc aaa gag gag atg  gag cct        4859
Ser Phe Leu  Glu Ile Ile Ser Ser  Ile Lys Glu Glu Met  Glu Pro            
        1260                 1265                 1270                    

ggc ttc cgg  gag gtc tcc ttc tac  tac agc gag gag aac  aag ctg        4904
Gly Phe Arg  Glu Val Ser Phe Tyr  Tyr Ser Glu Glu Asn  Lys Leu            
        1275                 1280                 1285                    

ccc gag ccg  gag gag ctg gac ctg  gag cca gag aac atg  gag agc        4949
Pro Glu Pro  Glu Glu Leu Asp Leu  Glu Pro Glu Asn Met  Glu Ser            
        1290                 1295                 1300                    

gtc ccc ctg  gac ccc tcg gcc tcc  tcg tcc tcc ctg cca  ctg ccc        4994
Val Pro Leu  Asp Pro Ser Ala Ser  Ser Ser Ser Leu Pro  Leu Pro            
        1305                 1310                 1315                    

gac aga cac  tca gga cac aag gcc  gag aac ggc ccc ggc  cct ggg        5039
Asp Arg His  Ser Gly His Lys Ala  Glu Asn Gly Pro Gly  Pro Gly            
        1320                 1325                 1330                    

gtg ctg gtc  ctc cgc gcc agc ttc  gac gag aga cag cct  tac gcc        5084
Val Leu Val  Leu Arg Ala Ser Phe  Asp Glu Arg Gln Pro  Tyr Ala            
        1335                 1340                 1345                    

cac atg aac  ggg ggc cgc aag aac  gag cgg gcc ttg ccg  ctg ccc        5129
His Met Asn  Gly Gly Arg Lys Asn  Glu Arg Ala Leu Pro  Leu Pro            
        1350                 1355                 1360                    

cag tct tcg  acc tgc tga tccttggatc ctgaatctgt gcaaacagta             5177
Gln Ser Ser  Thr Cys                                                      
        1365                                                              

acgtgtgcgc acgcgcagcg gggtgggggg ggagagagag ttttaacaat ccattcacaa     5237

gcctcctgta cctcagtgga tcttcagaac tgcccttgct gcccgcggga gacagcttct     5297

ctgcagtaaa acacatttgg gatgttcctt ttttcaatat gcaagcagct ttttattccc     5357

tgcccaaacc cttaactgac atgggccttt aagaacctta atgacaacac ttaatagcaa     5417

cagagcactt gagaaccagt ctcctcactc tgtccctgtc cttccctgtt ctccctttct     5477

ctctcctctc tgcttcataa cggaaaaata attgccacaa gtccagctgg gaagcccttt     5537

ttatcagttt gaggaagtgg ctgtccctgt ggccccatcc aaccactgta cacacccgcc     5597

tgacaccgtg ggtcattaca aaaaaacacg tggagatgga aatttttacc tttatctttc     5657

acctttctag ggacatgaaa tttacaaagg gccatcgttc atccaaggct gttaccattt     5717

taacgctgcc taattttgcc aaaatcctga actttctccc tcatcggccc ggcgctgatt     5777

cctcgtgtcc ggaggcatgg gtgagcatgg cagctggttg ctccatttga gagacacgct     5837

ggcgacacac tccgtccatc cgactgcccc tgctgtgctg ctcaaggcca caggcacaca     5897

ggtctcattg cttctgacta gattattatt tgggggaact ggacacaata ggtctttctc     5957

tcagtgaagg tggggagaag ctgaaccggc ttccctgccc tgcctcccca gccccctgcc     6017

caacccccaa gaatctggtg gccatgggcc ccgaagcagc ctggcggaca ggcttggagt     6077

caaggggccc catgcctgct tctctcccag ccccagctcc cccgcccgcc cccaaggaca     6137

cagatgggaa ggggtttcca gggactcagc cccactgttg atgcaggttt gcaaggaaag     6197

aaattcaaac accacaacag cagtaagaag aaaagcagtc aatggattca agcattctaa     6257

gctttgttga cattttctct gttcctagga cttcttcatg ggtcttacag ttctatgtta     6317

gaccatgaaa catttgcata cacatcgtct ttaatgtcac ttttataact tttttacggt     6377

tcagatattc atctatacgt ctgtacagaa aaaaaaaagc tgctattttt tttgttcttg     6437

atctttgtgg atttaatcta tgaaaacctt caggtccacc ctctcccctt tctgctcact     6497

ccaagaaact tcttatgctt tgtactagag tgcgtgactt tcttcctctt ttcccggtaa     6557

tggatacttc tatcacataa tttgccatga actgttggat gcctttttat aaatacatcc     6617

cccatccctg ctcccacctg cccctttagt tgttttctaa cccgtaggct ctctgggcac     6677

gaggcagaaa gcaggccggg cacccatcct gagagggccg cgctcctctc cccagcctgc     6737

cctcacagca ttggagcctg ttacagtgca agacatgata caaactcagg tcagaaaaac     6797

aaaggttaaa tatttcacac gtctttgttc agtgtttcca ctcaccgtgg ttgagaagcc     6857

tcaccctctc tttcccttgc ctttgcttag gttgtgacac acatatatat atattttttt     6917

aattcttggg tacaacagca gtgttaaccg cagacactag gcatttggat tactattttt     6977

cttaatggct atttaatcct tccatcccac gaaaaacagc tgctgagtcc aagggagcag     7037

cagagcgtgg tccggcaggg cctgttgtgg ccctcgccac ccccctcacc ggaccgactg     7097

acctgtcttt ggaaccagaa catcccaagg gaactccttc gcactggcgt tgagtgggac     7157

cccgggatcc aggctggccc agggcggcac cctcagggct gtgcccgctg gagtgctagg     7217

tggaggcagc acagacgcca cggtggccca agagcccctt tgcttcttgc tgggggacca     7277

gggctgtggt gctggcccac tttccctcgg ccaggaatcc aggtccttgg ggcccagggg     7337

tcttgtcttg tttcattttt agcacttctc accagagaga tgacagcaca agagttgctt     7397

ctgggataga aatgtttagg agtaagaaca aagctgggat acggtgattg ctagttgtga     7457

ctgaagattc aacacagaaa agaaagttta tacggctttt ttgctggtca gcagtttgtc     7517

ccactgcttt ctctagtctc tatcccatag cgtgttccct ttaaaaaaaa aaaaaaggta     7577

ttatatgtag gagttttctt ttaatttatt ttgtgataaa ttaccagttt caatcactgt     7637

agaaaagccc cattatgaat ttaaatttca aggaaagggt gtgtgtgtgt gtatgtgtgg     7697

ggtgtgtgtg tgtgagagtg atgggacagt tcttgatttt ttgggttttt tttcccccaa     7757

acatttatct acctcactct tattttttat atgtgtatat agacaaaaga atacatctca     7817

cctttctcag cacctgacaa taggccgttg atactggtaa cctcatccac gccacaggcg     7877

ccacacccag gtgatgcagg gggaagccag gctgtattcc ggggtcaaag caacactaac     7937

tcacctctct gctcatttca gacagcttgc ctttttctga gatgtcctgt tttgtgttgc     7997

tttttttgtt ttgttttcta tcttggtttc caccaaggtg ttagatttct cctcctccta     8057

gccaggtggc cctgtgaggc caacgagggc accagagcac acctggggga gccaccaggc     8117

tgtccctggc tggttgtctt tggaacaaac tgcttctgtg cagatggaat gaccaacaca     8177

tttcgtcctt aagagagcag tggttcctca ggttctgagg agaggaaggt gtccaggcag     8237

caccatctct gtgcgaatcc ccagggtaaa ggcgtggggc attgggtttg ctccccttgc     8297

tgctgctcca tccctgcagg aggctcgcgc tgaggcagga ccgtgcggcc atggctgctg     8357

cattcattga gcacaaaggt gcagctgcag cagcagctgg agagcaagag tcacccagcc     8417

tgtgcgccag aatgcagagg ctcctgacct cacagccagt ccctgataga acacacgcag     8477

gagcagagtc ccctccccct ccaggctgcc ctctcaactt ctccctcacc tccttcccta     8537

ggggtagaca gagatgtacc aaaccttccg gctggaaagc ccagtggccg gcgccgaggc     8597

tcgtggcgtc acgccccccc cgccagggct gtacctccgt ctccctggtc ctgctgctca     8657

caggacagac ggctcgctcc cctcttccag cagctgctct tacaggcact gatgatttcg     8717

ctgggaagtg tggcgggcag ctttgcctaa gcgtggatgg ctcctcggca attccagcct     8777

aagtgaaggc gctcaggagc ctcctgctgg aacgcgaccc atctctccca ggaccccggg     8837

gatcttaagg tcattgagaa atactgttgg atcagggttt tgttcttcca cactgtaggt     8897

gaccccttgg aataacggcc tctcctctcg tgcacatacc taccggtttc cacaactgga     8957

tttctacaga tcattcagct ggttataagg gttttgttta aactgtccga gttactgatg     9017

tcattttgtt tttgttttat gtaggtagct tttaagtaga aaacactaac agtgtagtgc     9077

ccatcatagc aaatgcttca gaaacacctc aataaaagag aaaacttggc ttgtgtgatg     9137

gtgcagtcac tttactggac caacccaccc accttgacta taccaaggca tcatctatcc     9197

acagttctag cctaacttca tgctgatttc tctgcctctt gatttttctc tgtgtgttcc     9257

aaataatctt aagctgagtt gtggcatttt ccatgcaacc tccttctgcc agcagctcac     9317

actgcttgaa gtcatatgaa ccactgaggc acatcatgga attgatgtga gcattaagac     9377

gttctcccac acagcccttc cctgaggcag caggagctgg tgtgtactgg agacactgtt     9437

gaacttgatc aagacccaga ccaccccagg tctccttcgt gggatgtcat gacgtttgac     9497

atacctttgg aacgagcctc ctccttggaa gatggaagac cgtgttcgtg gccgacctgg     9557

cctctcctgg cctgtttctt aagatgcgga gtcacatttc aatggtacga aaagtggctt     9617

cgtaaaatag aagagcagtc actgtggaac taccaaatgg cgagatgctc ggtgcacatt     9677

ggggtgcttt gggataaaag atttatgagc caactattct ctggcaccag attctaggcc     9737

agtttgttcc actgaagctt ttcccacagc agtccacctc tgcaggctgg cagccgaatg     9797

gcttgccagt ggctctgtgg caagatcaca ctgagatcga tgggtgagaa ggctaggatg     9857

cttgtctagt gttcttagct gtcacgttgg ctccttccag ggtggccaga cggtgttggc     9917

cactcccttc taaaacacag gcgccctcct ggtgacagtg acccgccgtg gtatgccttg     9977

gcccattcca gcagtcccag ttatgcattt caagtttggg gtttgttctt ttcgttaatg    10037

ttcctctgtg ttgtcagctg tcttcatttc ctgggctaag cagcattggg agatgtggac    10097

cagagatcca ctccttaaga accagtggcg aaagacactt tctttcttca ctctgaagta    10157

gctggtggta caaatgagaa cttcaagaga ggatgttatt tagactgaac ctctgttgcc    10217

agagatgctg aagatacaga ccttggacag gtcagagggt ttcatttttg gccttcatct    10277

tagatgactg gttgcgtcat ttggagaagt gagtgctcct tgatggtgga atgaccgggt    10337

ggtgggtaca gaaccattgt cacagggatc ctggcacaga gaagagttac gagcagcagg    10397

gtgcagggct tggaaggaat gtgggcaagg ttttgaactt gattgttctt gaagctatca    10457

gaccacatcg aggctcagca gtcatccgtg ggcatttggt ttcaacaaag aaacctaaca    10517

tcctactctg gaaactgatc tcggagttaa ggcgaattgt tcaagaacac aaactacatc    10577

gcactcgtca gttgtcagtt ctggggcatg actttagcgt tttgtttctg cgagaacata    10637

acgatcactc atttttatgt cccacgtgtg tgtgtccgca tctttctggt caacattgtt    10697

ttaactagtc actcattagc gttttcaata gggctcttaa gtccagtaga ttacgggtag    10757

tcagttgacg aagatctggt ttacaagaac taattaaatg tttcattgca tttttgtaag    10817

aacagaataa ttttataaaa tgtttgtagt ttataattgc cgaaaataat ttaaagacac    10877

tttttttttc tctgtgtgtg caaatgtgtg tttgtgatcc attttttttt ttttttttta    10937

ggacacctgt ttactagcta gctttacaat atgccaaaaa aggatttctc cctgacccca    10997

tccgtggttc accctctttt ccccccatgc tttttgccct agtttataac aaaggaatga    11057

tgatgattta aaaagtagtt ctgtatcttc agtatcttgg tcttccagaa ccctctggtt    11117

gggaagggga tcatttttta ctggtcattt ccctttggag tgtagctact ttaacagatg    11177

gaaagaacct cattggccat ggaaacagcc gaggtgttgg agcccagcag tgcatggcac    11237

cgttcggcat ctggcttgat tggtctggct gccgtcattg tcagcacagt gccatggaca    11297

tgggaagact tgactgcaca gccaatggtt ttcatgatga ttacagcata cacagtgatc    11357

acataaacga tgacagctat ggggcacaca ggccatttgc ttacatgcct cgtatcatga    11417

ctgattactg ctttgttaga acacagaaga gaccctattt tatttaaggc agaaccccga    11477

agatacgtat ttccaataca gaaaagaatt tttaataaaa actataacat acacaaaaat    11537

tggttttaaa gttgactcca cttcctctaa ctccagtgga ttgttggcca tgtctcccca    11597

actccacaat atctctatca tgggaaacac ctggggtttt tgcgctacat aggagaaaga    11657

tctggaaact atttgggttt tgttttcaac ttttcatttg gatgtttggc gttgcacaca    11717

cacatccacc ggtggaagag acgcccggtg aaaacacctg tctgctttct aagccagtga    11777

ggttgaggtg agaggtttgc cagagtttgt ctacctctgg gtatcccttt gtctgggata    11837

aaaaaaatca aaccagaagg cgggatggaa tggatgcacc gcaaataatg cattttctga    11897

gttttcttgt taaaaaaaaa tttttttaag taagaaaaaa aaaggtaata acatggccaa    11957

tttgttacat aaaatgactt tctgtgtata aattattcct aaaaaatcct gtttatataa    12017

aaaatcagta gatgaaaaaa atttcaaaat gtttttgtat attctgttgt aagaatttat    12077

tcctgttatt gcgatatact ctggattctt tacataatgg aaaaaagaaa ctgtctattt    12137

tgaatggctg aagctaaggc aacgttagtt tctcttactc tgcttttttc tagtaaagta    12197

ctacatggtt taagttaaat aaaataattc tgtatgcaaa aaaaaaaaaa aaaaaaaaaa    12257

aaaaa                                                                12262


<210>  4
<211>  1367
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val 
    930                 935                 940                 


Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg 
945                 950                 955                 960 


Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val 
                965                 970                 975     


Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp 
            980                 985                 990         


Glu Val Ala Arg Glu Lys Ile Thr  Met Ser Arg Glu Leu  Gly Gln Gly 
        995                 1000                 1005             


Ser Phe  Gly Met Val Tyr Glu  Gly Val Ala Lys Gly  Val Val Lys 
    1010                 1015                 1020             


Asp Glu  Pro Glu Thr Arg Val  Ala Ile Lys Thr Val  Asn Glu Ala 
    1025                 1030                 1035             


Ala Ser  Met Arg Glu Arg Ile  Glu Phe Leu Asn Glu  Ala Ser Val 
    1040                 1045                 1050             


Met Lys  Glu Phe Asn Cys His  His Val Val Arg Leu  Leu Gly Val 
    1055                 1060                 1065             


Val Ser  Gln Gly Gln Pro Thr  Leu Val Ile Met Glu  Leu Met Thr 
    1070                 1075                 1080             


Arg Gly  Asp Leu Lys Ser Tyr  Leu Arg Ser Leu Arg  Pro Glu Met 
    1085                 1090                 1095             


Glu Asn  Asn Pro Val Leu Ala  Pro Pro Ser Leu Ser  Lys Met Ile 
    1100                 1105                 1110             


Gln Met  Ala Gly Glu Ile Ala  Asp Gly Met Ala Tyr  Leu Asn Ala 
    1115                 1120                 1125             


Asn Lys  Phe Val His Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val 
    1130                 1135                 1140             


Ala Glu  Asp Phe Thr Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg 
    1145                 1150                 1155             


Asp Ile  Tyr Glu Thr Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu 
    1160                 1165                 1170             


Leu Pro  Val Arg Trp Met Ser  Pro Glu Ser Leu Lys  Asp Gly Val 
    1175                 1180                 1185             


Phe Thr  Thr Tyr Ser Asp Val  Trp Ser Phe Gly Val  Val Leu Trp 
    1190                 1195                 1200             


Glu Ile  Ala Thr Leu Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn 
    1205                 1210                 1215             


Glu Gln  Val Leu Arg Phe Val  Met Glu Gly Gly Leu  Leu Asp Lys 
    1220                 1225                 1230             


Pro Asp  Asn Cys Pro Asp Met  Leu Phe Glu Leu Met  Arg Met Cys 
    1235                 1240                 1245             


Trp Gln  Tyr Asn Pro Lys Met  Arg Pro Ser Phe Leu  Glu Ile Ile 
    1250                 1255                 1260             


Ser Ser  Ile Lys Glu Glu Met  Glu Pro Gly Phe Arg  Glu Val Ser 
    1265                 1270                 1275             


Phe Tyr  Tyr Ser Glu Glu Asn  Lys Leu Pro Glu Pro  Glu Glu Leu 
    1280                 1285                 1290             


Asp Leu  Glu Pro Glu Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser 
    1295                 1300                 1305             


Ala Ser  Ser Ser Ser Leu Pro  Leu Pro Asp Arg His  Ser Gly His 
    1310                 1315                 1320             


Lys Ala  Glu Asn Gly Pro Gly  Pro Gly Val Leu Val  Leu Arg Ala 
    1325                 1330                 1335             


Ser Phe  Asp Glu Arg Gln Pro  Tyr Ala His Met Asn  Gly Gly Arg 
    1340                 1345                 1350             


Lys Asn  Glu Arg Ala Leu Pro  Leu Pro Gln Ser Ser  Thr Cys 
    1355                 1360                 1365         


