                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
 
<120>  OPTIMIZATION OF ENZYME REPLACEMENT THERAPY FOR THE TREATMENT OF HOMOCYSTINURIA

<130>  2089.1004PCT

<140>  PCT/US18/XXXXX
<141>  2018-04-17

<150>  US 62/486,246
<151>  2017-04-17

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  413
<212>  PRT
<213>  Homo sapiens


<400>  1

Met Pro Ser Glu Thr Pro Gln Ala Glu Val Gly Pro Thr Gly Cys Pro 
1               5                   10                  15      


His Arg Ser Gly Pro His Ser Ala Lys Gly Ser Leu Glu Lys Gly Ser 
            20                  25                  30          


Pro Glu Asp Lys Glu Ala Lys Glu Pro Leu Trp Ile Arg Pro Asp Ala 
        35                  40                  45              


Pro Ser Arg Cys Thr Trp Gln Leu Gly Arg Pro Ala Ser Glu Ser Pro 
    50                  55                  60                  


His His His Thr Ala Pro Ala Lys Ser Pro Lys Ile Leu Pro Asp Ile 
65                  70                  75                  80  


Leu Lys Lys Ile Gly Asp Thr Pro Met Val Arg Ile Asn Lys Ile Gly 
                85                  90                  95      


Lys Lys Phe Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe 
            100                 105                 110         


Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu 
        115                 120                 125             


Asp Ala Glu Arg Asp Gly Thr Leu Lys Pro Gly Asp Thr Ile Ile Glu 
    130                 135                 140                 


Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val 
145                 150                 155                 160 


Arg Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Ser Glu 
                165                 170                 175     


Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro 
            180                 185                 190         


Thr Asn Ala Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp 
        195                 200                 205             


Arg Leu Lys Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg 
    210                 215                 220                 


Asn Ala Ser Asn Pro Leu Ala His Tyr Asp Thr Thr Ala Asp Glu Ile 
225                 230                 235                 240 


Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Val Gly 
                245                 250                 255     


Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys 
            260                 265                 270         


Pro Gly Cys Arg Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala 
        275                 280                 285             


Glu Pro Glu Glu Leu Asn Gln Thr Glu Gln Thr Thr Tyr Glu Val Glu 
    290                 295                 300                 


Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Thr Val Val 
305                 310                 315                 320 


Asp Lys Trp Phe Lys Ser Asn Asp Glu Glu Ala Phe Thr Phe Ala Arg 
                325                 330                 335     


Met Leu Ile Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ala Gly Ser 
            340                 345                 350         


Thr Val Ala Val Ala Val Lys Ala Ala Gln Glu Leu Gln Glu Gly Gln 
        355                 360                 365             


Arg Cys Val Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Thr Lys 
    370                 375                 380                 


Phe Leu Ser Asp Arg Trp Met Leu Gln Lys Gly Phe Leu Lys Glu Glu 
385                 390                 395                 400 


Asp Leu Thr Glu Lys Lys Pro Trp Trp Trp His Leu Arg 
                405                 410             


<210>  2
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Ser Glu Thr Pro Gln Ala Glu Val Gly Pro Thr Gly Ser Pro His 
1               5                   10                  15      


Arg Ser Gly Pro His Ser Ala Lys Gly Ser Leu Glu Lys Gly Ser Pro 
            20                  25                  30          


Glu 
    


<210>  3
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Val Gly Pro Thr Gly Ser Pro His Arg Ser Gly Pro His Ser Ala 
1               5                   10                  15      


Lys Gly Ser Leu Glu Lys Gly Ser Pro Glu 
            20                  25      


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Lys Glu Ala Lys Glu Pro Leu Trp Ile Arg Pro 
1               5                   10          


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Pro Leu Trp Ile Arg Pro 
1               5           


<210>  6
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ala Pro Ser Arg Cys Thr Trp Gln Leu Gly Arg Pro Ala Ser Glu 
1               5                   10                  15      


Ser Pro His His His Thr Ala Pro Ala Lys Ser Pro Lys Ile Leu Pro 
            20                  25                  30          


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Ile Leu Lys Lys Ile Gly 
1               5           


<210>  8
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Thr Pro Met Val Arg Ile Asn Lys Ile Gly Lys Lys Phe Gly Leu 
1               5                   10                  15      


Lys Cys Glu Leu Leu 
            20      


<210>  9
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Lys Cys Glu Phe Phe Asn Ala Gly Gly Ser Val Lys 
1               5                   10              


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Arg Ile Ser Leu Arg Met Ile Glu 
1               5                   


<210>  11
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Gly Thr Leu Lys Pro Gly 
1               5           


<210>  12
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Thr Ile Ile Glu Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala 
1               5                   10                  15      


Leu Ala Ala Ala Val Arg Gly Tyr Arg Cys Ile Ile Val Met Pro Glu 
            20                  25                  30          


Lys Met Ser Ser Glu Lys Val 
        35                  


<210>  13
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro Thr Asn 
1               5                   10                  15      


Ala Arg Phe 
            


<210>  14
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Ser Pro Glu Ser His Val Gly Val Ala Trp Arg Leu Lys Asn Glu 
1               5                   10                  15      


Ile Pro Asn Ser His Ile Leu 
            20              


<210>  15
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Gln Tyr Arg Asn Ala Ser Asn Pro Leu Ala His Tyr 
1               5                   10              


<210>  16
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Glu Ile Leu Gln Gln Cys 
1               5           


<210>  17
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Gly Lys Leu 
1               


<210>  18
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Met Leu Val Ala Ser Val Gly Thr Gly Gly Thr Ile Thr Gly Ile 
1               5                   10                  15      


Ala Arg Lys Leu Lys 
            20      


<210>  19
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Lys Cys Pro Gly Cys Arg Ile Ile Gly Val Asp Pro Glu Gly Ser 
1               5                   10                  15      


Ile Leu Ala Glu Pro Glu Glu Leu Asn Gln Thr Glu Gln Thr Thr Tyr 
            20                  25                  30          


<210>  20
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Val Glu Gly Ile Gly Tyr 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Phe Ile Pro Thr Val Leu 
1               5           


<210>  22
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Arg Thr Val Val 
1               5   


<210>  23
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Lys Trp Phe Lys Ser Asn 
1               5           


<210>  24
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Glu Glu Ala Phe Thr Phe Ala Arg Met Leu Ile Ala Gln Glu Gly 
1               5                   10                  15      


Leu Leu Cys Gly Gly Ser Ala Gly Ser Thr Val Ala Val Ala Val Lys 
            20                  25                  30          


Ala Ala Gln Glu Leu Gln 
        35              


<210>  25
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  25

Thr Phe Ala Arg Met Leu Ile Ala Gln Glu Gly Leu 
1               5                   10          


<210>  26
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Leu Gln Glu Gly Gln Arg Cys Val Val Ile Leu Pro 
1               5                   10              


<210>  27
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Gly Gln Arg Cys Val Val Ile Leu Pro 
1               5                   10  


<210>  28
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  28

Asp Ser Val Arg Asn Tyr Met Thr Lys Phe Leu Ser 
1               5                   10          


<210>  29
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Arg Trp Met Leu Gln Lys Gly Phe Leu Lys Glu Glu 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  30

Asp Leu Thr Glu Lys Lys Pro Trp Trp Trp His Leu Arg 
1               5                   10              


<210>  31
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  31

Cys Pro Gly Cys Arg Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu 
1               5                   10                  15      


Ala Glu Pro Glu Glu Leu Asn Gln Thr Glu Gln Thr Thr Tyr Glu Val 
            20                  25                  30          


Glu Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Thr Val 
        35                  40                  45              


Val Asp Lys 
    50      


<210>  32
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  32

Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Val Gly Thr Gly Gly 
1               5                   10                  15      


Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu 
            20                  25          


