                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
 
<120>  RECOMBINATION ACTIVATING GENE (RAG) INDUCED V(D)J GENE TARGETING

<130>  2546709

<140>  US 62/487,799
<141>  2017-04-20

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  931
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  RAG-1 Accession number: AAH37344.1

<400>  1

Met Ala Ala Ser Phe Pro Pro Thr Leu Gly Leu Ser Ser Ala Pro Asp 
1               5                   10                  15      


Glu Ile Gln His Pro His Ile Lys Phe Ser Glu Trp Lys Phe Lys Leu 
            20                  25                  30          


Phe Arg Val Arg Ser Phe Glu Lys Thr Pro Glu Glu Ala Gln Lys Glu 
        35                  40                  45              


Lys Lys Asp Ser Phe Glu Gly Lys Pro Ser Leu Glu Gln Ser Pro Ala 
    50                  55                  60                  


Val Leu Asp Lys Ala Asp Gly Gln Lys Pro Val Pro Thr Gln Pro Leu 
65                  70                  75                  80  


Leu Lys Ala His Pro Lys Phe Ser Lys Lys Phe His Asp Asn Glu Lys 
                85                  90                  95      


Ala Arg Gly Lys Ala Ile His Gln Ala Asn Leu Arg His Leu Cys Arg 
            100                 105                 110         


Ile Cys Gly Asn Ser Phe Arg Ala Asp Glu His Asn Arg Arg Tyr Pro 
        115                 120                 125             


Val His Gly Pro Val Asp Gly Lys Thr Leu Gly Leu Leu Arg Lys Lys 
    130                 135                 140                 


Glu Lys Arg Ala Thr Ser Trp Pro Asp Leu Ile Ala Lys Val Phe Arg 
145                 150                 155                 160 


Ile Asp Val Lys Ala Asp Val Asp Ser Ile His Pro Thr Glu Phe Cys 
                165                 170                 175     


His Asn Cys Trp Ser Ile Met His Arg Lys Phe Ser Ser Ala Pro Cys 
            180                 185                 190         


Glu Val Tyr Phe Pro Arg Asn Val Thr Met Glu Trp His Pro His Thr 
        195                 200                 205             


Pro Ser Cys Asp Ile Cys Asn Thr Ala Arg Arg Gly Leu Lys Arg Lys 
    210                 215                 220                 


Ser Leu Gln Pro Asn Leu Gln Leu Ser Lys Lys Leu Lys Thr Val Leu 
225                 230                 235                 240 


Asp Gln Ala Arg Gln Ala Arg Gln Arg Lys Arg Arg Ala Gln Ala Arg 
                245                 250                 255     


Ile Ser Ser Lys Asp Val Met Lys Lys Ile Ala Asn Cys Ser Lys Ile 
            260                 265                 270         


His Leu Ser Thr Lys Leu Leu Ala Val Asp Phe Pro Glu His Phe Val 
        275                 280                 285             


Lys Ser Ile Ser Cys Gln Ile Cys Glu His Ile Leu Ala Asp Pro Val 
    290                 295                 300                 


Glu Thr Asn Cys Lys His Val Phe Cys Arg Val Cys Ile Leu Arg Cys 
305                 310                 315                 320 


Leu Lys Val Met Gly Ser Tyr Cys Pro Ser Cys Arg Tyr Pro Cys Phe 
                325                 330                 335     


Pro Thr Asp Leu Glu Ser Pro Val Lys Ser Phe Leu Ser Val Leu Asn 
            340                 345                 350         


Ser Leu Met Val Lys Cys Pro Ala Lys Glu Cys Asn Glu Glu Val Ser 
        355                 360                 365             


Leu Glu Lys Tyr Asn His His Ile Ser Ser His Lys Glu Ser Lys Glu 
    370                 375                 380                 


Ile Phe Val His Ile Asn Lys Gly Gly Arg Pro Arg Gln His Leu Leu 
385                 390                 395                 400 


Ser Leu Thr Arg Arg Ala Gln Lys His Arg Leu Arg Glu Leu Lys Leu 
                405                 410                 415     


Gln Val Lys Ala Phe Ala Asp Lys Glu Glu Gly Gly Asp Val Lys Ser 
            420                 425                 430         


Val Cys Met Thr Leu Phe Leu Leu Ala Leu Arg Ala Arg Asn Glu His 
        435                 440                 445             


Arg Gln Ala Asp Glu Leu Glu Ala Ile Met Gln Gly Lys Gly Ser Gly 
    450                 455                 460                 


Leu Gln Pro Ala Val Cys Leu Ala Ile Arg Val Asn Thr Phe Leu Ser 
465                 470                 475                 480 


Cys Ser Gln Tyr His Lys Met Tyr Arg Thr Val Lys Ala Ile Thr Gly 
                485                 490                 495     


Arg Gln Ile Phe Gln Pro Leu His Ala Leu Arg Asn Ala Glu Lys Val 
            500                 505                 510         


Leu Leu Pro Gly Tyr His His Phe Glu Trp Gln Pro Pro Leu Lys Asn 
        515                 520                 525             


Val Ser Ser Ser Thr Asp Val Gly Ile Ile Asp Gly Leu Ser Gly Leu 
    530                 535                 540                 


Ser Ser Ser Val Asp Asp Tyr Pro Val Asp Thr Ile Ala Lys Arg Phe 
545                 550                 555                 560 


Arg Tyr Asp Ser Ala Leu Val Ser Ala Leu Met Asp Met Glu Glu Asp 
                565                 570                 575     


Ile Leu Glu Gly Met Arg Ser Gln Asp Leu Asp Asp Tyr Leu Asn Gly 
            580                 585                 590         


Pro Phe Thr Val Val Val Lys Glu Ser Cys Asp Gly Met Gly Asp Val 
        595                 600                 605             


Ser Glu Lys His Gly Ser Gly Pro Val Val Pro Glu Lys Ala Val Arg 
    610                 615                 620                 


Phe Ser Phe Thr Ile Met Lys Ile Thr Ile Ala His Ser Ser Gln Asn 
625                 630                 635                 640 


Val Lys Val Phe Glu Glu Ala Lys Pro Asn Ser Glu Leu Cys Cys Lys 
                645                 650                 655     


Pro Leu Cys Leu Met Leu Ala Asp Glu Ser Asp His Glu Thr Leu Thr 
            660                 665                 670         


Ala Ile Leu Ser Pro Leu Ile Ala Glu Arg Glu Ala Met Lys Ser Ser 
        675                 680                 685             


Glu Leu Met Leu Glu Leu Gly Gly Ile Leu Arg Thr Phe Lys Phe Ile 
    690                 695                 700                 


Phe Arg Gly Thr Gly Tyr Asp Glu Lys Leu Val Arg Glu Val Glu Gly 
705                 710                 715                 720 


Leu Glu Ala Ser Gly Ser Val Tyr Ile Cys Thr Leu Cys Asp Ala Thr 
                725                 730                 735     


Arg Leu Glu Ala Ser Gln Asn Leu Val Phe His Ser Ile Thr Arg Ser 
            740                 745                 750         


His Ala Glu Asn Leu Glu Arg Tyr Glu Val Trp Arg Ser Asn Pro Tyr 
        755                 760                 765             


His Glu Ser Val Glu Glu Leu Arg Asp Arg Val Lys Gly Val Ser Ala 
    770                 775                 780                 


Lys Pro Phe Ile Glu Thr Val Pro Ser Ile Asp Ala Leu His Cys Asp 
785                 790                 795                 800 


Ile Gly Asn Ala Ala Glu Phe Tyr Lys Ile Phe Gln Leu Glu Ile Gly 
                805                 810                 815     


Glu Val Tyr Lys Asn Pro Asn Ala Ser Lys Glu Glu Arg Lys Arg Trp 
            820                 825                 830         


Gln Ala Thr Leu Asp Lys His Leu Arg Lys Lys Met Asn Leu Lys Pro 
        835                 840                 845             


Ile Met Arg Met Asn Gly Asn Phe Ala Arg Lys Leu Met Thr Lys Glu 
    850                 855                 860                 


Thr Val Asp Ala Val Cys Glu Leu Ile Pro Ser Glu Glu Arg His Glu 
865                 870                 875                 880 


Ala Leu Arg Glu Leu Met Asp Leu Tyr Leu Lys Met Lys Pro Val Trp 
                885                 890                 895     


Arg Ser Ser Cys Pro Ala Lys Glu Cys Pro Glu Ser Leu Cys Gln Tyr 
            900                 905                 910         


Ser Phe Asn Ser Gln Arg Phe Ala Glu Leu Leu Ser Thr Lys Phe Lys 
        915                 920                 925             


Tyr Arg Asn 
    930     


<210>  2
<211>  2796
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  RAG-1 Accession number: BC037344.2

<400>  2
atggcagcct ctttcccacc caccttggga ctcagttctg ccccagatga aattcagcac       60

ccacatatta aattttcaga atggaaattt aagctgttcc gggtgagatc ctttgaaaag      120

acacctgaag aagctcaaaa ggaaaagaag gattcctttg aggggaaacc ctctctggag      180

caatctccag cagtcctgga caaggctgat ggtcagaagc cagtcccaac tcagccattg      240

ttaaaagccc accctaagtt ttcaaagaaa tttcacgaca acgagaaagc aagaggcaaa      300

gcgatccatc aagccaacct tcgacatctc tgccgcatct gtgggaattc ttttagagct      360

gatgagcaca acaggagata tccagtccat ggtcctgtgg atggtaaaac cctaggcctt      420

ttacgaaaga aggaaaagag agctacttcc tggccggacc tcattgccaa ggttttccgg      480

atcgatgtga aggcagatgt tgactcgatc caccccactg agttctgcca taactgctgg      540

agcatcatgc acaggaagtt tagcagtgcc ccatgtgagg tttacttccc gaggaacgtg      600

accatggagt ggcaccccca cacaccatcc tgtgacatct gcaacactgc ccgtcgggga      660

ctcaagagga agagtcttca gccaaacttg cagctcagca aaaaactcaa aactgtgctt      720

gaccaagcaa gacaagcccg tcagcgcaag agaagagctc aggcaaggat cagcagcaag      780

gatgtcatga agaagatcgc caactgcagt aagatacatc ttagtaccaa gctccttgca      840

gtggacttcc cagagcactt tgtgaaatcc atctcctgcc agatctgtga acacattctg      900

gctgaccctg tggagaccaa ctgtaagcat gtcttttgcc gggtctgcat tctcagatgc      960

ctcaaagtca tgggcagcta ttgtccctct tgccgatatc catgcttccc tactgacctg     1020

gagagtccag tgaagtcctt tctgagcgtc ttgaattccc tgatggtgaa atgtccagca     1080

aaagagtgca atgaggaggt cagtttggaa aaatataatc accacatctc aagtcacaag     1140

gaatcaaaag agatttttgt gcacattaat aaagggggcc ggccccgcca acatcttctg     1200

tcgctgactc ggagagctca gaagcaccgg ctgagggagc tcaagctgca agtcaaagcc     1260

tttgctgaca aagaagaagg tggagatgtg aagtccgtgt gcatgacctt gttcctgctg     1320

gctctgaggg cgaggaatga gcacaggcaa gctgatgagc tggaggccat catgcaggga     1380

aagggctctg gcctgcagcc agctgtttgc ttggccatcc gtgtcaacac cttcctcagc     1440

tgcagtcagt accacaagat gtacaggact gtgaaagcca tcacagggag acagattttt     1500

cagcctttgc atgcccttcg gaatgctgag aaggtacttc tgccaggcta ccaccacttt     1560

gagtggcagc cacctctgaa gaatgtgtct tccagcactg atgttggcat tattgatggg     1620

ctgtctgggc tatcatcctc tgtggatgat tacccagtgg acaccattgc aaagaggttc     1680

cgctatgatt cagctttggt gtctgctttg atggacatgg aagaagacat cttggaaggc     1740

atgagatccc aagaccttga tgattacctg aatggcccct tcactgtggt ggtgaaggag     1800

tcttgtgatg gaatgggaga cgtgagtgag aagcatggga gtgggcctgt agttccagaa     1860

aaggcagtcc gtttttcatt cacaatcatg aaaattacta ttgcccacag ctctcagaat     1920

gtgaaagtat ttgaagaagc caaacctaac tctgaactgt gttgcaagcc attgtgcctt     1980

atgctggcag atgagtctga ccacgagacg ctgactgcca tcctgagtcc tctcattgct     2040

gagagggagg ccatgaagag cagtgaatta atgcttgagc tgggaggcat tctccggact     2100

ttcaagttca tcttcagggg caccggctat gatgaaaaac ttgtgcggga agtggaaggc     2160

ctcgaggctt ctggctcagt ctacatttgt actctttgtg atgccacccg tctggaagcc     2220

tctcaaaatc ttgtcttcca ctctataacc agaagccatg ctgagaacct ggaacgttat     2280

gaggtctggc gttccaaccc ttaccatgag tctgtggaag aactgcggga tcgggtgaaa     2340

ggggtctcag ctaaaccttt cattgagaca gtcccttcca tagatgcact ccactgtgac     2400

attggcaatg cagctgagtt ctacaagatc ttccagctag agatagggga agtgtataag     2460

aatcccaatg cttccaaaga ggaaaggaaa aggtggcagg ccacactgga caagcatctc     2520

cggaagaaga tgaacctcaa accaatcatg aggatgaatg gcaactttgc caggaagctc     2580

atgaccaaag agactgtgga tgcagtttgt gagttaattc cttccgagga gaggcacgag     2640

gctctgaggg agctgatgga tctttacctg aagatgaaac cagtatggcg atcatcatgc     2700

cctgctaaag agtgcccaga atccctctgc cagtacagtt tcaattcaca gcgttttgct     2760

gagctccttt ctacgaagtt caagtataga aattaa                               2796


<210>  3
<211>  1040
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  RAG-1 Accession number: NP_033045.2

<400>  3

Met Ala Ala Ser Leu Pro Ser Thr Leu Ser Phe Ser Ser Ala Pro Asp 
1               5                   10                  15      


Glu Ile Gln His Pro Gln Ile Lys Phe Ser Glu Trp Lys Phe Lys Leu 
            20                  25                  30          


Phe Arg Val Arg Ser Phe Glu Lys Ala Pro Glu Glu Ala Gln Lys Glu 
        35                  40                  45              


Lys Asp Ser Ser Glu Gly Lys Pro Tyr Leu Glu Gln Ser Pro Val Val 
    50                  55                  60                  


Pro Glu Lys Pro Gly Gly Gln Asn Ser Ile Leu Thr Gln Arg Ala Leu 
65                  70                  75                  80  


Lys Leu His Pro Lys Phe Ser Lys Lys Phe His Ala Asp Gly Lys Ser 
                85                  90                  95      


Ser Asp Lys Ala Val His Gln Ala Arg Leu Arg His Phe Cys Arg Ile 
            100                 105                 110         


Cys Gly Asn Arg Phe Lys Ser Asp Gly His Ser Arg Arg Tyr Pro Val 
        115                 120                 125             


His Gly Pro Val Asp Ala Lys Thr Gln Ser Leu Phe Arg Lys Lys Glu 
    130                 135                 140                 


Lys Arg Val Thr Ser Trp Pro Asp Leu Ile Ala Arg Ile Phe Arg Ile 
145                 150                 155                 160 


Asp Val Lys Ala Asp Val Asp Ser Ile His Pro Thr Glu Phe Cys His 
                165                 170                 175     


Asp Cys Trp Ser Ile Met His Arg Lys Phe Ser Ser Ser His Ser Gln 
            180                 185                 190         


Val Tyr Phe Pro Arg Lys Val Thr Val Glu Trp His Pro His Thr Pro 
        195                 200                 205             


Ser Cys Asp Ile Cys Phe Thr Ala His Arg Gly Leu Lys Arg Lys Arg 
    210                 215                 220                 


His Gln Pro Asn Val Gln Leu Ser Lys Lys Leu Lys Thr Val Leu Asn 
225                 230                 235                 240 


His Ala Arg Arg Asp Arg Arg Lys Arg Thr Gln Ala Arg Val Ser Ser 
                245                 250                 255     


Lys Glu Val Leu Lys Lys Ile Ser Asn Cys Ser Lys Ile His Leu Ser 
            260                 265                 270         


Thr Lys Leu Leu Ala Val Asp Phe Pro Ala His Phe Val Lys Ser Ile 
        275                 280                 285             


Ser Cys Gln Ile Cys Glu His Ile Leu Ala Asp Pro Val Glu Thr Ser 
    290                 295                 300                 


Cys Lys His Leu Phe Cys Arg Ile Cys Ile Leu Arg Cys Leu Lys Val 
305                 310                 315                 320 


Met Gly Ser Tyr Cys Pro Ser Cys Arg Tyr Pro Cys Phe Pro Thr Asp 
                325                 330                 335     


Leu Glu Ser Pro Val Lys Ser Phe Leu Asn Ile Leu Asn Ser Leu Met 
            340                 345                 350         


Val Lys Cys Pro Ala Gln Asp Cys Asn Glu Glu Val Ser Leu Glu Lys 
        355                 360                 365             


Tyr Asn His His Val Ser Ser His Lys Glu Ser Lys Glu Thr Leu Val 
    370                 375                 380                 


His Ile Asn Lys Gly Gly Arg Pro Arg Gln His Leu Leu Ser Leu Thr 
385                 390                 395                 400 


Arg Arg Ala Gln Lys His Arg Leu Arg Glu Leu Lys Ile Gln Val Lys 
                405                 410                 415     


Glu Phe Ala Asp Lys Glu Glu Gly Gly Asp Val Lys Ala Val Cys Leu 
            420                 425                 430         


Thr Leu Phe Leu Leu Ala Leu Arg Ala Arg Asn Glu His Arg Gln Ala 
        435                 440                 445             


Asp Glu Leu Glu Ala Ile Met Gln Gly Arg Gly Ser Gly Leu Gln Pro 
    450                 455                 460                 


Ala Val Cys Leu Ala Ile Arg Val Asn Thr Phe Leu Ser Cys Ser Gln 
465                 470                 475                 480 


Tyr His Lys Met Tyr Arg Thr Val Lys Ala Ile Thr Gly Arg Gln Ile 
                485                 490                 495     


Phe Gln Pro Leu His Ala Leu Arg Asn Ala Glu Lys Val Leu Leu Pro 
            500                 505                 510         


Gly Tyr His Pro Phe Glu Trp Gln Pro Pro Leu Lys Asn Val Ser Ser 
        515                 520                 525             


Arg Thr Asp Val Gly Ile Ile Asp Gly Leu Ser Gly Leu Ala Ser Ser 
    530                 535                 540                 


Val Asp Glu Tyr Pro Val Asp Thr Ile Ala Lys Arg Phe Arg Tyr Asp 
545                 550                 555                 560 


Ser Ala Leu Val Ser Ala Leu Met Asp Met Glu Glu Asp Ile Leu Glu 
                565                 570                 575     


Gly Met Arg Ser Gln Asp Leu Asp Asp Tyr Leu Asn Gly Pro Phe Thr 
            580                 585                 590         


Val Val Val Lys Glu Ser Cys Asp Gly Met Gly Asp Val Ser Glu Lys 
        595                 600                 605             


His Gly Ser Gly Pro Ala Val Pro Glu Lys Ala Val Arg Phe Ser Phe 
    610                 615                 620                 


Thr Val Met Arg Ile Thr Ile Glu His Gly Ser Gln Asn Val Lys Val 
625                 630                 635                 640 


Phe Glu Glu Pro Lys Pro Asn Ser Glu Leu Cys Cys Lys Pro Leu Cys 
                645                 650                 655     


Leu Met Leu Ala Asp Glu Ser Asp His Glu Thr Leu Thr Ala Ile Leu 
            660                 665                 670         


Ser Pro Leu Ile Ala Glu Arg Glu Ala Met Lys Ser Ser Glu Leu Thr 
        675                 680                 685             


Leu Glu Met Gly Gly Ile Pro Arg Thr Phe Lys Phe Ile Phe Arg Gly 
    690                 695                 700                 


Thr Gly Tyr Asp Glu Lys Leu Val Arg Glu Val Glu Gly Leu Glu Ala 
705                 710                 715                 720 


Ser Gly Ser Val Tyr Ile Cys Thr Leu Cys Asp Thr Thr Arg Leu Glu 
                725                 730                 735     


Ala Ser Gln Asn Leu Val Phe His Ser Ile Thr Arg Ser His Ala Glu 
            740                 745                 750         


Asn Leu Gln Arg Tyr Glu Val Trp Arg Ser Asn Pro Tyr His Glu Ser 
        755                 760                 765             


Val Glu Glu Leu Arg Asp Arg Val Lys Gly Val Ser Ala Lys Pro Phe 
    770                 775                 780                 


Ile Glu Thr Val Pro Ser Ile Asp Ala Leu His Cys Asp Ile Gly Asn 
785                 790                 795                 800 


Ala Ala Glu Phe Tyr Lys Ile Phe Gln Leu Glu Ile Gly Glu Val Tyr 
                805                 810                 815     


Lys His Pro Asn Ala Ser Lys Glu Glu Arg Lys Arg Trp Gln Ala Thr 
            820                 825                 830         


Leu Asp Lys His Leu Arg Lys Arg Met Asn Leu Lys Pro Ile Met Arg 
        835                 840                 845             


Met Asn Gly Asn Phe Ala Arg Lys Leu Met Thr Gln Glu Thr Val Asp 
    850                 855                 860                 


Ala Val Cys Glu Leu Ile Pro Ser Glu Glu Arg His Glu Ala Leu Arg 
865                 870                 875                 880 


Glu Leu Met Asp Leu Tyr Leu Lys Met Lys Pro Val Trp Arg Ser Ser 
                885                 890                 895     


Cys Pro Ala Lys Glu Cys Pro Glu Ser Leu Cys Gln Tyr Ser Phe Asn 
            900                 905                 910         


Ser Gln Arg Phe Ala Glu Leu Leu Ser Thr Lys Phe Lys Tyr Arg Tyr 
        915                 920                 925             


Glu Gly Lys Ile Thr Asn Tyr Phe His Lys Thr Leu Ala His Val Pro 
    930                 935                 940                 


Glu Ile Ile Glu Arg Asp Gly Ser Ile Gly Ala Trp Ala Ser Glu Gly 
945                 950                 955                 960 


Asn Glu Ser Gly Asn Lys Leu Phe Arg Arg Phe Arg Lys Met Asn Ala 
                965                 970                 975     


Arg Gln Ser Lys Cys Tyr Glu Met Glu Asp Val Leu Lys His His Trp 
            980                 985                 990         


Leu Tyr Thr Ser Lys Tyr Leu Gln  Lys Phe Met Asn Ala  His Asn Ala 
        995                 1000                 1005             


Leu Lys  Ser Ser Gly Phe Thr  Met Asn Ser Lys Glu  Thr Leu Gly 
    1010                 1015                 1020             


Asp Pro  Leu Gly Ile Glu Asp  Ser Leu Glu Ser Gln  Asp Ser Met 
    1025                 1030                 1035             


Glu Phe  
    1040 


<210>  4
<211>  3123
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  RAG-1 Accession number: NM_009019.2

<400>  4
atggctgcct ccttgccgtc taccctgagc ttcagttctg cacccgatga aattcaacac       60

ccacaaatca aattttccga gtggaaattt aagctgttta gggtgagatc ctttgaaaag      120

gcacccgaag aagcacagaa ggagaaggat tcctcagagg ggaaacctta cctagaacag      180

tctccagtag ttccagagaa gcctggtggt cagaactcaa ttctgactca acgagcactg      240

aaactccatc ctaaattttc aaagaaattc catgctgatg ggaagtcaag cgacaaagca      300

gttcaccaag ccaggcttag acacttctgc cgcatctgtg ggaatcgttt caagagtgac      360

gggcacagcc ggagataccc agtccacggg cccgtggacg ctaaaaccca aagtcttttc      420

cgaaagaagg aaaaaagagt cacttcctgg ccagacctca ttgccaggat tttccggatc      480

gacgtgaagg cagatgttga ctccatccac ccgacggaat tctgccatga ctgttggagc      540

atcatgcaca gaaagttcag cagttcccac agtcaggtct acttcccaag gaaagtgacc      600

gtggagtggc acccccacac accgtcctgt gacatctgtt ttactgccca tcggggactc      660

aagaggaaga gacatcagcc caatgtgcag ctcagcaaga aactaaaaac tgtgctcaac      720

cacgcgagac gggaccgtcg caagagaact caggctaggg tcagcagcaa ggaagtcctg      780

aagaagatct ccaactgcag taagattcat ctcagtacca agcttcttgc cgtggacttc      840

ccagcacact ttgtgaaatc catctcctgc cagatatgcg aacacattct ggctgatccc      900

gtggagacca gctgcaagca tctattctgt aggatctgca ttctcagatg tctcaaagtc      960

atgggcagct attgtccctc ttgccgatat ccgtgcttcc ctactgacct ggagagccca     1020

gtgaagtcct ttctgaacat cttgaattct ctcatggtca agtgtcccgc gcaagattgc     1080

aatgaggaag tgagtctgga aaaatataac caccatgtgt caagccacaa agaatctaaa     1140

gagactttgg tgcatatcaa taaaggggga cggcctcgcc agcatctcct gtcactgacg     1200

agaagggcgc agaaacatcg gctgagggag ctcaagattc aagtcaaaga atttgctgac     1260

aaagaagaag gtggagatgt gaaggctgtc tgcttgacat tgtttctcct ggcactgagg     1320

gcgaggaatg agcacaggca agctgatgaa ttagaggcca tcatgcaagg caggggctcc     1380

gggcttcaac cagctgtttg cttggccatc cgtgtcaata ccttcctcag ctgtagccaa     1440

taccataaga tgtacaggac tgtgaaagct atcactggga ggcagatttt tcaacctttg     1500

catgctcttc ggaatgccga gaaagtcctt ctgccaggct accatccctt tgagtggcag     1560

cccccactga agaatgtgtc ctccagaact gatgttggaa ttattgatgg gctgtctgga     1620

cttgcctcct ctgtggatga gtacccagta gataccattg cgaagaggtt ccgctacgac     1680

tctgctttgg tgtctgcttt gatggacatg gaagaagaca tcttggaagg catgagatcc     1740

caagatcttg atgactacct gaatggtccc ttcacagtgg tggtaaagga gtcttgcgat     1800

ggaatggggg atgtgagtga gaagcacggg agtgggcccg cagttccaga aaaggccgtt     1860

cgtttctctt tcacagtcat gagaattacg atagagcatg gttcacagaa cgtgaaggtg     1920

tttgaggaac ccaagcccaa ttctgaactg tgttgcaagc cgttgtgtct tatgctggca     1980

gatgagtctg accatgagac ccttactgct attctaagcc ccctcattgc cgagagggag     2040

gccatgaaga gcagtgaatt aacgctggag atgggaggca tccccaggac ttttaaattc     2100

atcttcaggg gcactggata cgatgaaaaa cttgtccggg aagtagaagg cttggaagct     2160

tctggctcag tctacatctg tacactctgt gacaccaccc gtttggaagc ctctcagaat     2220

cttgtcttcc actccataac cagaagccac gccgagaacc tgcagcgcta tgaggtctgg     2280

cggtccaatc cgtatcatga gtccgtggaa gagctccggg accgggtgaa aggggtctct     2340

gccaaacctt tcatcgagac agtcccttcc atagatgcgc ttcactgtga cattggcaat     2400

gcagctgaat tctataagat tttccagctg gagatagggg aagtgtataa acatcccaat     2460

gcctctaaag aggaaaggaa gagatggcag gccacgctgg acaaacatct ccggaaaagg     2520

atgaacttaa aaccaatcat gaggatgaat ggcaactttg cccggaagct tatgacccaa     2580

gagactgtag acgcagtttg tgagttaatt ccttctgagg agaggcatga agctctcagg     2640

gagctcatgg acctttacct gaagatgaaa cccgtgtggc gctcttcatg tcccgctaaa     2700

gagtgtccag agtccctctg tcagtacagt ttcaactcac agcgtttcgc ggaactcctc     2760

tccaccaagt tcaaatatag atacgagggc aaaatcacca attactttca caaaaccttg     2820

gcacatgtcc ctgaaattat tgaaagggat ggctctatcg gggcctgggc aagtgaggga     2880

aatgaatcgg gtaacaagct gtttagacgg tttcggaaaa tgaatgccag gcagtccaag     2940

tgctatgaga tggaagatgt cctgaaacat cactggctgt atacttcaaa atacctccag     3000

aagtttatga atgctcataa cgcgttaaaa agctctgggt ttaccatgaa ctcaaaggag     3060

accttagggg accctttggg cattgaggac tctctggaaa gccaagattc aatggagttt     3120

taa                                                                   3123


<210>  5
<211>  527
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  RAG-2 Accession number: NP_001230715.1

<400>  5

Met Ser Leu Gln Met Val Thr Val Ser Asn Asn Ile Ala Leu Ile Gln 
1               5                   10                  15      


Pro Gly Phe Ser Leu Met Asn Phe Asp Gly Gln Val Phe Phe Phe Gly 
            20                  25                  30          


Gln Lys Gly Trp Pro Lys Arg Ser Cys Pro Thr Gly Val Phe His Leu 
        35                  40                  45              


Asp Val Lys His Asn His Val Lys Leu Lys Pro Thr Ile Phe Ser Lys 
    50                  55                  60                  


Asp Ser Cys Tyr Leu Pro Pro Leu Arg Tyr Pro Ala Thr Cys Thr Phe 
65                  70                  75                  80  


Lys Gly Ser Leu Glu Ser Glu Lys His Gln Tyr Ile Ile His Gly Gly 
                85                  90                  95      


Lys Thr Pro Asn Asn Glu Val Ser Asp Lys Ile Tyr Val Met Ser Ile 
            100                 105                 110         


Val Cys Lys Asn Asn Lys Lys Val Thr Phe Arg Cys Thr Glu Lys Asp 
        115                 120                 125             


Leu Val Gly Asp Val Pro Glu Ala Arg Tyr Gly His Ser Ile Asn Val 
    130                 135                 140                 


Val Tyr Ser Arg Gly Lys Ser Met Gly Val Leu Phe Gly Gly Arg Ser 
145                 150                 155                 160 


Tyr Met Pro Ser Thr His Arg Thr Thr Glu Lys Trp Asn Ser Val Ala 
                165                 170                 175     


Asp Cys Leu Pro Cys Val Phe Leu Val Asp Phe Glu Phe Gly Cys Ala 
            180                 185                 190         


Thr Ser Tyr Ile Leu Pro Glu Leu Gln Asp Gly Leu Ser Phe His Val 
        195                 200                 205             


Ser Ile Ala Lys Asn Asp Thr Ile Tyr Ile Leu Gly Gly His Ser Leu 
    210                 215                 220                 


Ala Asn Asn Ile Arg Pro Ala Asn Leu Tyr Arg Ile Arg Val Asp Leu 
225                 230                 235                 240 


Pro Leu Gly Ser Pro Ala Val Asn Cys Thr Val Leu Pro Gly Gly Ile 
                245                 250                 255     


Ser Val Ser Ser Ala Ile Leu Thr Gln Thr Asn Asn Asp Glu Phe Val 
            260                 265                 270         


Ile Val Gly Gly Tyr Gln Leu Glu Asn Gln Lys Arg Met Ile Cys Asn 
        275                 280                 285             


Ile Ile Ser Leu Glu Asp Asn Lys Ile Glu Ile Arg Glu Met Glu Thr 
    290                 295                 300                 


Pro Asp Trp Thr Pro Asp Ile Lys His Ser Lys Ile Trp Phe Gly Ser 
305                 310                 315                 320 


Asn Met Gly Asn Gly Thr Val Phe Leu Gly Ile Pro Gly Asp Asn Lys 
                325                 330                 335     


Gln Val Val Ser Glu Gly Phe Tyr Phe Tyr Met Leu Lys Cys Ala Glu 
            340                 345                 350         


Asp Asp Thr Asn Glu Glu Gln Thr Thr Phe Thr Asn Ser Gln Thr Ser 
        355                 360                 365             


Thr Glu Asp Pro Gly Asp Ser Thr Pro Phe Glu Asp Ser Glu Glu Phe 
    370                 375                 380                 


Cys Phe Ser Ala Glu Ala Asn Ser Phe Asp Gly Asp Asp Glu Phe Asp 
385                 390                 395                 400 


Thr Tyr Asn Glu Asp Asp Glu Glu Asp Glu Ser Glu Thr Gly Tyr Trp 
                405                 410                 415     


Ile Thr Cys Cys Pro Thr Cys Asp Val Asp Ile Asn Thr Trp Val Pro 
            420                 425                 430         


Phe Tyr Ser Thr Glu Leu Asn Lys Pro Ala Met Ile Tyr Cys Ser His 
        435                 440                 445             


Gly Asp Gly His Trp Val His Ala Gln Cys Met Asp Leu Ala Glu Arg 
    450                 455                 460                 


Thr Leu Ile His Leu Ser Ala Gly Ser Asn Lys Tyr Tyr Cys Asn Glu 
465                 470                 475                 480 


His Val Glu Ile Ala Arg Ala Leu His Thr Pro Gln Arg Val Leu Pro 
                485                 490                 495     


Leu Lys Lys Pro Pro Met Lys Ser Leu Arg Lys Lys Gly Ser Gly Lys 
            500                 505                 510         


Ile Leu Thr Pro Ala Lys Lys Ser Phe Leu Arg Arg Leu Phe Asp 
        515                 520                 525         


<210>  6
<211>  1584
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  RAG-2 Accession number: NM_001243786.1

<400>  6
atgtctctgc agatggtaac agtcagtaat aacatagcct taattcagcc aggcttctca       60

ctgatgaatt ttgatggaca agttttcttc tttggacaaa aaggctggcc caaaagatcc      120

tgccccactg gagttttcca tctggatgta aagcataacc atgtcaaact gaagcctaca      180

attttctcta aggattcctg ctacctccct cctcttcgct acccagccac ttgcacattc      240

aaaggcagct tggagtctga aaagcatcaa tacatcatcc atggagggaa aacaccaaac      300

aatgaggttt cagataagat ttatgtcatg tctattgttt gcaagaacaa caaaaaggtt      360

acttttcgct gcacagagaa agacttggta ggagatgttc ctgaagccag atatggtcat      420

tccattaatg tggtgtacag ccgagggaaa agtatgggtg ttctctttgg aggacgctca      480

tacatgcctt ctacccacag aaccacagaa aaatggaata gtgtagctga ctgcctgccc      540

tgtgttttcc tggtggattt tgaatttggg tgtgctacat catacattct tccagaactt      600

caggatgggc tatcttttca tgtctctatt gccaaaaatg acaccatcta tattttagga      660

ggacattcac ttgccaataa tatccggcct gccaacctgt acagaataag ggttgatctt      720

cccctgggta gcccagctgt gaattgcaca gtcttgccag gaggaatctc tgtctccagt      780

gcaatcctga ctcaaactaa caatgatgaa tttgttattg ttggtggcta tcagcttgaa      840

aatcaaaaaa gaatgatctg caacatcatc tctttagagg acaacaagat agaaattcgt      900

gagatggaga ccccagattg gaccccagac attaagcaca gcaagatatg gtttggaagc      960

aacatgggaa atggaactgt ttttcttggc ataccaggag acaataaaca agttgtttca     1020

gaaggattct atttctatat gttgaaatgt gctgaagatg atactaatga agagcagaca     1080

acattcacaa acagtcaaac atcaacagaa gatccagggg attccactcc ctttgaagac     1140

tctgaagaat tttgtttcag tgcagaagca aatagttttg atggtgatga tgaatttgac     1200

acctataatg aagatgatga agaagatgag tctgagacag gctactggat tacatgctgc     1260

cctacttgtg atgtggatat caacacttgg gtaccattct attcaactga gctcaacaaa     1320

cccgccatga tctactgctc tcatggggat gggcactggg tccatgctca gtgcatggat     1380

ctggcagaac gcacactcat ccatctgtca gcaggaagca acaagtatta ctgcaatgag     1440

catgtggaga tagcaagagc tctacacact ccccaaagag tcctaccctt aaaaaagcct     1500

ccaatgaaat ccctccgtaa aaaaggttct ggaaaaatct tgactcctgc caagaaatcc     1560

tttcttagaa ggttgtttga ttag                                            1584


<210>  7
<211>  527
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  RAG-2 Accession number: NP_033046.1

<400>  7

Met Ser Leu Gln Met Val Thr Val Gly His Asn Ile Ala Leu Ile Gln 
1               5                   10                  15      


Pro Gly Phe Ser Leu Met Asn Phe Asp Gly Gln Val Phe Phe Phe Gly 
            20                  25                  30          


Gln Lys Gly Trp Pro Lys Arg Ser Cys Pro Thr Gly Val Phe His Phe 
        35                  40                  45              


Asp Ile Lys Gln Asn His Leu Lys Leu Lys Pro Ala Ile Phe Ser Lys 
    50                  55                  60                  


Asp Ser Cys Tyr Leu Pro Pro Leu Arg Tyr Pro Ala Thr Cys Ser Tyr 
65                  70                  75                  80  


Lys Gly Ser Ile Asp Ser Asp Lys His Gln Tyr Ile Ile His Gly Gly 
                85                  90                  95      


Lys Thr Pro Asn Asn Glu Leu Ser Asp Lys Ile Tyr Ile Met Ser Val 
            100                 105                 110         


Ala Cys Lys Asn Asn Lys Lys Val Thr Phe Arg Cys Thr Glu Lys Asp 
        115                 120                 125             


Leu Val Gly Asp Val Pro Glu Pro Arg Tyr Gly His Ser Ile Asp Val 
    130                 135                 140                 


Val Tyr Ser Arg Gly Lys Ser Met Gly Val Leu Phe Gly Gly Arg Ser 
145                 150                 155                 160 


Tyr Met Pro Ser Thr Gln Arg Thr Thr Glu Lys Trp Asn Ser Val Ala 
                165                 170                 175     


Asp Cys Leu Pro His Val Phe Leu Ile Asp Phe Glu Phe Gly Cys Ala 
            180                 185                 190         


Thr Ser Tyr Ile Leu Pro Glu Leu Gln Asp Gly Leu Ser Phe His Val 
        195                 200                 205             


Ser Ile Ala Arg Asn Asp Thr Val Tyr Ile Leu Gly Gly His Ser Leu 
    210                 215                 220                 


Ala Ser Asn Ile Arg Pro Ala Asn Leu Tyr Arg Ile Arg Val Asp Leu 
225                 230                 235                 240 


Pro Leu Gly Thr Pro Ala Val Asn Cys Thr Val Leu Pro Gly Gly Ile 
                245                 250                 255     


Ser Val Ser Ser Ala Ile Leu Thr Gln Thr Asn Asn Asp Glu Phe Val 
            260                 265                 270         


Ile Val Gly Gly Tyr Gln Leu Glu Asn Gln Lys Arg Met Val Cys Ser 
        275                 280                 285             


Leu Val Ser Leu Gly Asp Asn Thr Ile Glu Ile Ser Glu Met Glu Thr 
    290                 295                 300                 


Pro Asp Trp Thr Ser Asp Ile Lys His Ser Lys Ile Trp Phe Gly Ser 
305                 310                 315                 320 


Asn Met Gly Asn Gly Thr Ile Phe Leu Gly Ile Pro Gly Asp Asn Lys 
                325                 330                 335     


Gln Ala Met Ser Glu Ala Phe Tyr Phe Tyr Thr Leu Arg Cys Ser Glu 
            340                 345                 350         


Glu Asp Leu Ser Glu Asp Gln Lys Ile Val Ser Asn Ser Gln Thr Ser 
        355                 360                 365             


Thr Glu Asp Pro Gly Asp Ser Thr Pro Phe Glu Asp Ser Glu Glu Phe 
    370                 375                 380                 


Cys Phe Ser Ala Glu Ala Thr Ser Phe Asp Gly Asp Asp Glu Phe Asp 
385                 390                 395                 400 


Thr Tyr Asn Glu Asp Asp Glu Asp Asp Glu Ser Val Thr Gly Tyr Trp 
                405                 410                 415     


Ile Thr Cys Cys Pro Thr Cys Asp Val Asp Ile Asn Thr Trp Val Pro 
            420                 425                 430         


Phe Tyr Ser Thr Glu Leu Asn Lys Pro Ala Met Ile Tyr Cys Ser His 
        435                 440                 445             


Gly Asp Gly His Trp Val His Ala Gln Cys Met Asp Leu Glu Glu Arg 
    450                 455                 460                 


Thr Leu Ile His Leu Ser Glu Gly Ser Asn Lys Tyr Tyr Cys Asn Glu 
465                 470                 475                 480 


His Val Gln Ile Ala Arg Ala Leu Gln Thr Pro Lys Arg Asn Pro Pro 
                485                 490                 495     


Leu Gln Lys Pro Pro Met Lys Ser Leu His Lys Lys Gly Ser Gly Lys 
            500                 505                 510         


Val Leu Thr Pro Ala Lys Lys Ser Phe Leu Arg Arg Leu Phe Asp 
        515                 520                 525         


<210>  8
<211>  1584
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  RAG-2 Accession number: NM_009020.3

<400>  8
atgtccctgc agatggtaac agtgggtcat aacatagcct taattcaacc aggcttctca       60

cttatgaatt ttgatggcca agttttcttc tttggccaga aaggctggcc taagagatcc      120

tgtcctactg gagtctttca ttttgatata aaacaaaatc atctcaaact gaagcctgca      180

atcttctcta aagattcctg ctacctccca cctcttcgtt atccagctac ttgctcatac      240

aaaggcagca tagactctga caagcatcaa tatatcattc acggagggaa aacaccaaac      300

aatgagcttt ccgataagat ttatatcatg tctgtcgctt gcaagaataa caaaaaagtt      360

actttccgtt gcacagagaa agacttagta ggagatgtcc ctgaacccag atacggccat      420

tccattgacg tggtgtatag tcgagggaaa agcatgggtg ttctctttgg aggacgttca      480

tacatgcctt ctacccagag aaccacagaa aaatggaata gtgtagctga ctgcctaccc      540

catgttttct tgatagattt tgaatttggg tgtgctacat catatattct cccagaactt      600

caggatgggc tgtcttttca tgtttctatt gccagaaacg ataccgttta tattttggga      660

ggacactcac ttgccagtaa tatacgccct gctaacttgt atagaataag agtggacctt      720

cccctgggta ccccagcagt gaattgcaca gtcttgccag gaggaatctc tgtctccagt      780

gcaatcctca ctcaaacaaa caatgatgaa tttgttattg tgggtggtta tcagctggaa      840

aatcagaaaa ggatggtctg cagccttgtc tctctagggg acaacacgat tgaaatcagt      900

gagatggaga ctcctgactg gacctcagat attaagcata gcaaaatatg gtttggaagc      960

aacatgggaa acgggactat tttccttggc ataccaggag acaataagca ggctatgtca     1020

gaagcattct atttctatac tttgagatgc tctgaagagg atttgagtga agatcagaaa     1080

attgtctcca acagtcagac atcaacagaa gatcctgggg actccactcc ctttgaagac     1140

tcagaggaat tttgtttcag tgctgaagca accagttttg atggtgacga tgaatttgac     1200

acctacaatg aagatgatga agatgacgag tctgtaaccg gctactggat aacatgttgc     1260

cctacttgtg atgttgacat caatacctgg gttccgttct attcaacgga gctcaataaa     1320

cccgccatga tctattgttc tcatggggat gggcactggg tacatgccca gtgcatggat     1380

ttggaagaac gcacactcat ccacttgtca gaaggaagca acaagtatta ttgcaatgaa     1440

catgtacaga tagcaagagc attgcaaact cccaaaagaa accccccctt acaaaaacct     1500

ccaatgaaat ccctccacaa aaaaggctct gggaaagtct tgactcctgc caagaaatcc     1560

ttccttagaa gactgtttga ttaa                                            1584


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein stabilizing sequence

<400>  9

Met Lys Lys Leu Lys Leu Arg Leu Thr His Leu Trp Tyr Lys Leu Leu 
1               5                   10                  15      


Met Lys Leu Gly Leu Lys Ser Asp Glu Val Tyr Tyr Ile 
            20                  25                  


<210>  10
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti CAR-CD19

<400>  10

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Ile Glu 
            260                 265                 270         


Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr 
        275                 280                 285             


Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
    290                 295                 300                 


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
305                 310                 315                 320 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
                325                 330                 335     


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
            340                 345                 350         


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
        355                 360                 365             


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  11
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti Tn-MUC1 CAR

<400>  11
atggaatggt cttgggtgtt cctgttcttc ctgagcgtga ccaccggcgt gcacagccag       60

gtgcagctgc agcagtctga tgccgagctc gtgaagcctg gcagcagcgt gaagatcagc      120

tgcaaggcca gcggctacac cttcaccgac cacgccatcc actgggtcaa gcagaagcct      180

gagcagggcc tggaatggat cggccacttc agccccggca acaccgacat caagtacaac      240

gacaagttca agggcaaggc caccctgacc gtggacagaa gcagcagcac cgcctacatg      300

cagctgaaca gcctgaccag cgaggacagc gccgtgtact tctgcaagac cagcaccttc      360

tttttcgact actggggcca gggcacaacc ctgacagtgt ctagcggcgg aggcggatct      420

ggcggcggag gatctggggg aggcggctct gaactcgtga tgacccagag ccccagctct      480

ctgacagtga cagccggcga gaaagtgacc atgatctgca agtcctccca gagcctgctg      540

aactccggcg accagaagaa ctacctgacc tggtatcagc agaaacccgg ccagcccccc      600

aagctgctga tcttttgggc cagcacccgg gaaagcggcg tgcccgatag attcacaggc      660

agcggctccg gcaccgactt taccctgacc atcagctccg tgcaggccga ggacctggcc      720

gtgtattact gccagaacga ctacagctac cccctgacct tcggagccgg caccaagctg      780

gaactgaag                                                              789


<210>  12
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1-specific TCR

<400>  12

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Ser Ser Gly Gly Gly Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Glu Leu Leu Pro Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220 


<210>  13
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3BNC117 (anti-HIV Antibody)

<400>  13

Gln Val Gln Leu Leu Gln Ser Gly Ala Ala Val Thr Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Ala Ser Gly Tyr Asn Ile Arg Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Trp Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Pro Lys Thr Gly Gln Pro Asn Asn Pro Arg Gln Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Leu Thr Arg His Ala Ser Trp Asp Phe Asp Thr 
65                  70                  75                  80  


Tyr Ser Phe Tyr Met Asp Leu Lys Ala Leu Arg Ser Asp Asp Thr Ala 
                85                  90                  95      


Val Tyr Phe Cys Ala Arg Gln Arg Ser Asp Tyr Trp Asp Phe Asp Val 
            100                 105                 110         


Trp Gly Ser Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys 
225     


<210>  14
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adalimumab (Humira) an anti-TNF? Antibody

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210>  15
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PankoMab-GEX an anti MUC1 glycoform Antibody heavy chain

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Leu Ser Cys Val Ala Ser Gly Phe Pro Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Lys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  16
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PankoMab-GEX an anti MUC1 glycoform Antibody light chain

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Asn Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ala 
            20                  25                  30          


Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Ala 
        


<210>  17
<211>  1200
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  iCasp9

<400>  17
atgctcgagg gagtgcaggt ggaaaccatc tccccaggag acgggcgcac cttccccaag       60

cgcggccaga cctgcgtggt gcactacacc gggatgcttg aagatggaaa gaaagttgat      120

tcctcccggg acagaaacaa gccctttaag tttatgctag gcaagcagga ggtgatccga      180

ggctgggaag aaggggttgc ccagatgagt gtgggtcaga gagccaaact gactatatct      240

ccagattatg cctatggtgc cactgggcac ccaggcatca tcccaccaca tgccactctc      300

gtcttcgatg tggagcttct aaaactggaa tctggcggtg gatccggagt cgacggattt      360

ggtgatgtcg gtgctcttga gagtttgagg ggaaatgcag atttggctta catcctgagc      420

atggagccct gtggccactg cctcattatc aacaatgtga acttctgccg tgagtccggg      480

ctccgcaccc gcactggctc caacatcgac tgtgagaagt tgcggcgtcg cttctcctcg      540

ctgcatttca tggtggaggt gaagggcgac ctgactgcca agaaaatggt gctggctttg      600

ctggagctgg cgcagcagga ccacggtgct ctggactgct gcgtggtggt cattctctct      660

cacggctgtc aggccagcca cctgcagttc ccaggggctg tctacggcac agatggatgc      720

cctgtgtcgg tcgagaagat tgtgaacatc ttcaatggga ccagctgccc cagcctggga      780

gggaagccca agctcttttt catccaggcc tgtggtgggg agcagaaaga ccatgggttt      840

gaggtggcct ccacttcccc tgaagacgag tcccctggca gtaaccccga gccagatgcc      900

accccgttcc aggaaggttt gaggaccttc gaccagctgg acgccatatc tagtttgccc      960

acacccagtg acatctttgt gtcctactct actttcccag gttttgtttc ctggagggac     1020

cccaagagtg gctcctggta cgttgagacc ctggacgaca tctttgagca gtgggctcac     1080

tctgaagacc tgcagtccct cctgcttagg gtcgctaatg ctgtttcggt gaaagggatt     1140

tataaacaga tgcctggttg ctttaatttc ctccggaaaa aacttttctt taaaacatca     1200


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-181a recognition element

<400>  18
actcaccgac agcgttgaat gtt                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ECMV IRES R1

<400>  19
catatagaca aacgcacacc ggc                                               23


<210>  20
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgKVm-rec-F1

<400>  20
gtccctgcca ggttyagtgg cagtggrtcw rggac                                  35


<210>  21
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mHA-SbfI-F1 primer

<400>  21
cttaccccta tgatgtgcct gactacgctt gca                                    33


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgKCm-rec-Rev2 primer

<400>  22
ggatggtgga agatggatac                                                   20


<210>  23
<211>  2529
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-polio BCR

<400>  23
atgaagctga gagtgggcca gacactgggc acaatcccta gacagtgcga ggtgctgctg       60

ctcctgctgc ttctgggact tgtggatgga gtgtcactgt ccccaggaca gacagccaac      120

atcgcctgct ctggagataa attggcggat aaatatatta actggtatca gcagaagtca      180

ggccagtccc ctgttctggt catctatgaa gatgcgaagc ggccctcagg gatccctgag      240

cgattctctg gctccagctc tgggaacaca gccactctaa ccatcagcgg gacccaggct      300

atggatgagg ctgactacta ctgtcaggcg tgggacaaca gcgctggata tgtattcgga      360

actgggacca aagtcaccgt cggtcagccc aagtccactc ccacactcac catgtttcca      420

ccttcccctg aggagctcca ggaaaacaaa gccacactcg tgtgtctgat ttccaatttt      480

tccccaagtg gtgtgacagt ggcctggaag gcaaatggta cacctatcac ccagggtgtg      540

gacacttcaa atcccaccaa agaggacaac aagtacatgg ccagcagctt cttacatttg      600

acatcggacc agtggagatc tcacaacagt tttacctgcc aagttacaca tgaaggggac      660

actgtggaga agagtctgtc tcctgcagaa tgtctcggca gcggcgccac aaacttctct      720

ctgctaaagc aagcaggtga tgttgaagaa aaccccgggc ctatggagtt tgggctgagc      780

tgggttttcc tcgttgctct ttttagaggt gtccagtgtc tcgagtcggg cccaggactg      840

gtgaagcctt cggagaccct gtccctcacc tgcagtgtct ctagtggctt catcagtctt      900

tattcgtgga gttggatccg ccaggcacca gggacgggac tggagtggat tgggtccatc      960

cgctatagtg agaccgccta ttacaacccg tccctcaggg gtcgagtctt catatcacta     1020

gacacgtcca agaatcactt ctccctgaag atgagttctc tgaccgccac agatacggcc     1080

gtttattatt gtgcgcgaga ctacagtaag agtggctacg atcgttcggg gcggttcgac     1140

ccctggggcc agggtacccc agtcatcgtc tccatgggct gcctggcccg ggacttcctg     1200

cccagcacca tttccttcac ctggaactac cagaacaaca ctgaagtcat ccagggtatc     1260

agaaccttcc caacactgag gacagggggc aagtacctag ccacctcgca ggtgttgctg     1320

tctcccaaga gcatccttga aggttcagat gaatacctgg tatgcaaaat ccactacgga     1380

ggcaaaaaca aagatctgca tgtgcccatt ccagctgtcg cagagatgaa ccccaatgta     1440

aatgtgttcg tcccaccacg ggatggcttc tctggccctg caccacgcaa gtctaaactc     1500

atctgcgagg ccacgaactt cactccaaaa ccgatcacag tatcctggct aaaggatggg     1560

aagctcgtgg aatctggctt caccacagat ccggtgacca tcgagaacaa aggatccaca     1620

ccccaaacct acaaggtcat aagcacactt accatctctg aaatcgactg gctgaacctg     1680

aatgtgtaca cctgccgtgt ggatcacagg ggtctcacct tcttgaagaa cgtgtcctcc     1740

acatgtgctg ccagtccctc cacagacatc ctaaccttca ccatcccccc ctcctttgcc     1800

gacatcttcc tcagcaagtc cgctaacctg acctgtctgg tctcaaacct ggcaacctat     1860

gaaaccctga atatctcctg ggcttctcaa agtggtgaac cactggaaac caaaattaaa     1920

atcatggaaa gccatcccaa tggcaccttc agtgctaagg gtgtggctag tgtttgtgtg     1980

gaagactgga ataacaggaa ggaatttgtg tgtactgtga ctcacaggga tctgccttca     2040

ccacagaaga aattcatctc aaaacccaat gaggtgcaca aacatccacc tgctgtgtac     2100

ctgctgccac cagctcgtga gcaactgaac ctgagggagt cagccacagt cacctgcctg     2160

gtgaagggct tctctcctgc agacatcagt gtgcagtggc ttcagagagg gcaactcttg     2220

ccccaagaga aatatgtgac cagtgccccg atgccagagc ctggggcccc aggcttctac     2280

tttacccaca gcatcctgac tgtgacagag gaggaatgga actccggaga gacctatacc     2340

tgtgttgtag gccacgaggc cctgccacac ctggtgaccg agaggaccgt ggacaagtcc     2400

actgaggggg aggtgaatgc tgaggaggaa ggctttgaga acctgtggac cactgcctcc     2460

accttcatcg tcctcttcct cctgagcctc ttctacagca ccaccgtcac cctgttcaag     2520

gtgaaatga                                                             2529


<210>  24
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-RSV BCR

<400>  24
atggcgacgg gttcaagaac ttccctactt cttgcatttg gcctgctttg tttgccgtgg       60

ttacaggagg gctcggcaga catccagatg acacagagcc cctctacact gagcgccagc      120

gtgggagaca gagtgaccat cacatgcaag tgccagctga gcgtgggcta catgcactgg      180

tatcagcaga agcctggcaa ggcccctaag ctgctgatct acgacacaag caagctggcc      240

tctggcgtgc cctctagatt ttctggcagc ggctctggca ccgagttcac cctgacaatc      300

tctagcctgc agcctgacga cttcgccacc tactactgct tccaaggctc tggctacccc      360

ttcacattcg gcggaggcac caagctggaa atcaaggtgg ccgctcccag cgtgttcatc      420

ttccctccct ctgatgaaca gctgaaaagc ggaacagcca gcgtggtgtg tctgctgaac      480

aacttctacc ccagagaagc caaagtgcag tggaaggtgg acaacgccct gcagagcgga      540

aacagccagg aaagcgtgac agagcaggat tccaaggatt ccacatacag cctgagcagc      600

acactgacac tgtccaaggc cgactacgag aagcacaagg tgtacgcctg cgaagtgaca      660

caccagggac tgtcctcccc tgtgacaaag agcttcaaca gaggagaatg ccgcgcgaaa      720

cgcggaagcg gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac      780

cctggaccta tggcgacggg ttcaagaact tccctacttc ttgcatttgg cctgctttgt      840

ttgccgtggt tacaggaggg ctcggcacaa gtgaccctga gagagtctgg ccccgctctg      900

gttaagccca cacagaccct gacactgacc tgcaccttca gcggcttcag cctgagcaca      960

agcggcatgt ctgtcggctg gatcagacag cctcctggca aggctctgga atggctggcc     1020

gacatttggt gggacgacaa gaaggactac aaccccagcc tgaagtccag actgaccatc     1080

agcaaggaca ccagcaagaa ccaggtggtg ctgaaagtga ccaacatgga ccctgccgac     1140

accgccacct actactgcgc cagatccatg atcaccaact ggtacttcga cgtctggggc     1200

gccggcacca cagtgacagt ttcttctagc accaagggcc catcggtctt ccccctggca     1260

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac     1320

ttccccgaac cggtgacggt gtcgtggaac tcaggcgctc tgaccagcgg cgtgcacacc     1380

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc     1440

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc     1500

aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc     1560

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     1620

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1680

gaccctgagg tcaagttcaa ctggtatgtt gacggcgtgg aggtgcataa tgccaagaca     1740

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1800

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1860

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1920

accctgcccc catcccggga tgagctgacc aagaatcaag tcagcctgac ctgcctggtc     1980

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     2040

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctactcaaaa     2100

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     2160

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg ttaa           2214


<210>  25
<211>  976
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V kappa  3-15 segment of the human IgK variable region and an HA 
       tag

<400>  25
ggcttgtgcc aaacatcttc tgggtggatt taggtgattg aggagaagaa agacacagga       60

gcgaaattct ctgagcacaa gggaggagtt ctacactcag actgagccaa cagacttttc      120

tggcctgaca accagggcgg cgcaggatgc tcagtgcaga gaggaagaaa caggtggtct      180

ctgcagctgg aagctcagct cccaccccag ctgctttgca tgtccctccc agctgcccta      240

ccttccagag cccatatcaa tgcctgggtc agagctctgg ggaggaactg ctcagttagg      300

acccagacgg aaccatggaa gccccagcgc agcttctctt cctcctgcta ctctggctcc      360

caggtgaggg gaatatgagg tgtctttgca catcagtgaa aactcctgcc acctctgctc      420

agcaagaaat ataattaaaa ttcaatgtag atcaacaatt ttggctctac ttaaagacag      480

tgggtttgat tttgattaca tgagtgcatt tctgttttat ttccaatttc agataccact      540

ggagaaatag tgatgacgca gtctccagcc accctgtctg tgtctccagg ggaaagagcc      600

accctctcct gcacttaccc ctatgatgtg cctgactacg cttgcactta cccctatgat      660

gtgcctgact acgcttgcag ggccagtcag agtgttagca gcaacttagc ctggtaccag      720

cagaaacctg gccaggctcc caggctcctc atctatggtg catccaccag ggccactggt      780

atcccagcca ggttcagtgg cagtgggtct gggacagagt tcactctcac catcagcagc      840

ctgcagtctg aagattttgc agtttattac tgtcagcagt ataataactg gcctcccaca      900

gtgattcaac atgaaacaaa aacctcaaga agaccatcag tgtttactag attataccag      960

ctgcttcctt tacaga                                                      976


<210>  26
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SA 97.66 splice acceptor

<400>  26
ttcctttttt tttcaggtgt cgtgaaaact acccct                                 36


<210>  27
<211>  575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ECMV IRES

<400>  27
cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg       60

tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg      120

gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg      180

aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca      240

aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct      300

ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca      360

cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa      420

ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggtg      480

cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc cgaaccacgg      540

ggacgtggtt ttcctttgaa aaacacgatg ataat                                 575


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A picornia Virus 2A peptide

<400>  28

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  29
<211>  4683
<212>  DNA
<213>  adeno-associated virus 6, complete genome


<220>
<221>  misc_feature
<223>  GenBank: AF028704.1

<400>  29
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagcgcca tgccggggtt ttacgagatt gtgattaagg tccccagcga      360

ccttgacgag catctgcccg gcatttctga cagctttgtg aactgggtgg ccgagaagga      420

atgggagttg ccgccagatt ctgacatgga tctgaatctg attgagcagg cacccctgac      480

cgtggccgag aagctgcagc gcgacttcct ggtccagtgg cgccgcgtga gtaaggcccc      540

ggaggccctc ttctttgttc agttcgagaa gggcgagtcc tacttccacc tccatattct      600

ggtggagacc acgggggtca aatccatggt gctgggccgc ttcctgagtc agattaggga      660

caagctggtg cagaccatct accgcgggat cgagccgacc ctgcccaact ggttcgcggt      720

gaccaagacg cgtaatggcg ccggaggggg gaacaaggtg gtggacgagt gctacatccc      780

caactacctc ctgcccaaga ctcagcccga gctgcagtgg gcgtggacta acatggagga      840

gtatataagc gcgtgtttaa acctggccga gcgcaaacgg ctcgtggcgc acgacctgac      900

ccacgtcagc cagacccagg agcagaacaa ggagaatctg aaccccaatt ctgacgcgcc      960

tgtcatccgg tcaaaaacct ccgcacgcta catggagctg gtcgggtggc tggtggaccg     1020

gggcatcacc tccgagaagc agtggatcca ggaggaccag gcctcgtaca tctccttcaa     1080

cgccgcctcc aactcgcggt cccagatcaa ggccgctctg gacaatgccg gcaagatcat     1140

ggcgctgacc aaatccgcgc ccgactacct ggtaggcccc gctccgcccg ccgacattaa     1200

aaccaaccgc atttaccgca tcctggagct gaacggctac gaccctgcct acgccggctc     1260

cgtctttctc ggctgggccc agaaaaggtt cggaaaacgc aacaccatct ggctgtttgg     1320

gccggccacc acgggcaaga ccaacatcgc ggaagccatc gcccacgccg tgcccttcta     1380

cggctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg acaagatggt     1440

gatctggtgg gaggagggca agatgacggc caaggtcgtg gagtccgcca aggccattct     1500

cggcggcagc aaggtgcgcg tggaccaaaa gtgcaagtcg tccgcccaga tcgatcccac     1560

ccccgtgatc gtcacctcca acaccaacat gtgcgccgtg attgacggga acagcaccac     1620

cttcgagcac cagcagccgt tgcaggaccg gatgttcaaa tttgaactca cccgccgtct     1680

ggagcatgac tttggcaagg tgacaaagca ggaagtcaaa gagttcttcc gctgggcgca     1740

ggatcacgtg accgaggtgg cgcatgagtt ctacgtcaga aagggtggag ccaacaagag     1800

acccgccccc gatgacgcgg ataaaagcga gcccaagcgg gcctgcccct cagtcgcgga     1860

tccatcgacg tcagacgcgg aaggagctcc ggtggacttt gccgacaggt accaaaacaa     1920

atgttctcgt cacgcgggca tgcttcagat gctgtttccc tgcaaaacat gcgagagaat     1980

gaatcagaat ttcaacattt gcttcacgca cgggaccaga gactgttcag aatgtttccc     2040

cggcgtgtca gaatctcaac cggtcgtcag aaagaggacg tatcggaaac tctgtgccat     2100

tcatcatctg ctggggcggg ctcccgagat tgcttgctcg gcctgcgatc tggtcaacgt     2160

ggatctggat gactgtgttt ctgagcaata aatgacttaa accaggtatg gctgccgatg     2220

gttatcttcc agattggctc gaggacaacc tctctgaggg cattcgcgag tggtgggact     2280

tgaaacctgg agccccgaaa cccaaagcca accagcaaaa gcaggacgac ggccggggtc     2340

tggtgcttcc tggctacaag tacctcggac ccttcaacgg actcgacaag ggggagcccg     2400

tcaacgcggc ggatgcagcg gccctcgagc acgacaaggc ctacgaccag cagctcaaag     2460

cgggtgacaa tccgtacctg cggtataacc acgccgacgc cgagtttcag gagcgtctgc     2520

aagaagatac gtcttttggg ggcaacctcg ggcgagcagt cttccaggcc aagaagaggg     2580

ttctcgaacc ttttggtctg gttgaggaag gtgctaagac ggctcctgga aagaaacgtc     2640

cggtagagca gtcgccacaa gagccagact cctcctcggg cattggcaag acaggccagc     2700

agcccgctaa aaagagactc aattttggtc agactggcga ctcagagtca gtccccgacc     2760

cacaacctct cggagaacct ccagcaaccc ccgctgctgt gggacctact acaatggctt     2820

caggcggtgg cgcaccaatg gcagacaata acgaaggcgc cgacggagtg ggtaatgcct     2880

caggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc accagcaccc     2940

gaacatgggc cttgcccacc tataacaacc acctctacaa gcaaatctcc agtgcttcaa     3000

cgggggccag caacgacaac cactacttcg gctacagcac cccctggggg tattttgatt     3060

tcaacagatt ccactgccat ttctcaccac gtgactggca gcgactcatc aacaacaatt     3120

ggggattccg gcccaagaga ctcaacttca agctcttcaa catccaagtc aaggaggtca     3180

cgacgaatga tggcgtcacg accatcgcta ataaccttac cagcacggtt caagtcttct     3240

cggactcgga gtaccagttg ccgtacgtcc tcggctctgc gcaccagggc tgcctccctc     3300

cgttcccggc ggacgtgttc atgattccgc agtacggcta cctaacgctc aacaatggca     3360

gccaggcagt gggacggtca tccttttact gcctggaata tttcccatcg cagatgctga     3420

gaacgggcaa taactttacc ttcagctaca ccttcgagga cgtgcctttc cacagcagct     3480

acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccag tacctgtatt     3540

acctgaacag aactcagaat cagtccggaa gtgcccaaaa caaggacttg ctgtttagcc     3600

gggggtctcc agctggcatg tctgttcagc ccaaaaactg gctacctgga ccctgttacc     3660

ggcagcagcg cgtttctaaa acaaaaacag acaacaacaa cagcaacttt acctggactg     3720

gtgcttcaaa atataacctt aatgggcgtg aatctataat caaccctggc actgctatgg     3780

cctcacacaa agacgacaaa gacaagttct ttcccatgag cggtgtcatg atttttggaa     3840

aggagagcgc cggagcttca aacactgcat tggacaatgt catgatcaca gacgaagagg     3900

aaatcaaagc cactaacccc gtggccaccg aaagatttgg gactgtggca gtcaatctcc     3960

agagcagcag cacagaccct gcgaccggag atgtgcatgt tatgggagcc ttacctggaa     4020

tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa attcctcaca     4080

cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag cacccgcctc     4140

ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag ttttcggcta     4200

caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg gagattgaat     4260

gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat acatctaact     4320

atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat actgagcctc     4380

gccccattgg cacccgttac ctcacccgtc ccctgtaatt gtgtgttaat caataaaccg     4440

gttaattcgt gtcagttgaa ctttggtctc atgtcgttat tatcttatct ggtcaccata     4500

gcaaccggtt acacattaac tgcttagttg cgcttcgcga atacccctag tgatggagtt     4560

gcccactccc tctatgcgcg ctcgctcgct cggtggggcc ggcagagcag agctctgccg     4620

tctgcggacc tttggtccgc aggccccacc gagcgagcga gcgcgcatag agggagtggg     4680

caa                                                                   4683


<210>  30
<211>  4393
<212>  DNA
<213>  adeno-associated virus 8, complete genome


<220>
<221>  misc_feature
<223>  NC_006261.1

<400>  30
cagagaggga gtggccaact ccatcactag gggtagcgcg aagcgcctcc cacgctgccg       60

cgtcagcgct gacgtaaatt acgtcatagg ggagtggtcc tgtattagct gtcacgtgag      120

tgcttttgcg gcattttgcg acaccacgtg gccatttgag gtatatatgg ccgagtgagc      180

gagcaggatc tccattttga ccgcgaaatt tgaacgagca gcagccatgc cgggcttcta      240

cgagatcgtg atcaaggtgc cgagcgacct ggacgagcac ctgccgggca tttctgactc      300

gtttgtgaac tgggtggccg agaaggaatg ggagctgccc ccggattctg acatggatcg      360

gaatctgatc gagcaggcac ccctgaccgt ggccgagaag ctgcagcgcg acttcctggt      420

ccaatggcgc cgcgtgagta aggccccgga ggccctcttc tttgttcagt tcgagaaggg      480

cgagagctac tttcacctgc acgttctggt cgagaccacg ggggtcaagt ccatggtgct      540

aggccgcttc ctgagtcaga ttcgggaaaa gcttggtcca gaccatctac ccgcggggtc      600

gagccccacc ttgcccaact ggttcgcggt gaccaaagac gcggtaatgg cgccggcggg      660

ggggaacaag gtggtggacg agtgctacat ccccaactac ctcctgccca agactcagcc      720

cgagctgcag tgggcgtgga ctaacatgga ggagtatata agcgcgtgct tgaacctggc      780

cgagcgcaaa cggctcgtgg cgcagcacct gacccacgtc agccagacgc aggagcagaa      840

caaggagaat ctgaacccca attctgacgc gcccgtgatc aggtcaaaaa cctccgcgcg      900

ctatatggag ctggtcgggt ggctggtgga ccggggcatc acctccgaga agcagtggat      960

ccaggaggac caggcctcgt acatctcctt caacgccgcc tccaactcgc ggtcccagat     1020

caaggccgcg ctggacaatg ccggcaagat catggcgctg accaaatccg cgcccgacta     1080

cctggtgggg ccctcgctgc ccgcggacat tacccagaac cgcatctacc gcatcctcgc     1140

tctcaacggc tacgaccctg cctacgccgg ctccgtcttt ctcggctggg ctcagaaaaa     1200

gttcgggaaa cgcaacacca tctggctgtt tggacccgcc accaccggca agaccaacat     1260

tgcggaagcc atcgcccacg ccgtgccctt ctacggctgc gtcaactgga ccaatgagaa     1320

ctttcccttc aatgattgcg tcgacaagat ggtgatctgg tgggaggagg gcaagatgac     1380

ggccaaggtc gtggagtccg ccaaggccat tctcggcggc agcaaggtgc gcgtggacca     1440

aaagtgcaag tcgtccgccc agatcgaccc cacccccgtg atcgtcacct ccaacaccaa     1500

catgtgcgcc gtgattgacg ggaacagcac caccttcgag caccagcagc ctctccagga     1560

ccggatgttt aagttcgaac tcacccgccg tctggagcac gactttggca aggtgacaaa     1620

gcaggaagtc aaagagttct tccgctgggc cagtgatcac gtgaccgagg tggcgcatga     1680

gttttacgtc agaaagggcg gagccagcaa aagacccgcc cccgatgacg cggataaaag     1740

cgagcccaag cgggcctgcc cctcagtcgc ggatccatcg acgtcagacg cggaaggagc     1800

tccggtggac tttgccgaca ggtaccaaaa caaatgttct cgtcacgcgg gcatgcttca     1860

gatgctgttt ccctgcaaaa cgtgcgagag aatgaatcag aatttcaaca tttgcttcac     1920

acacggggtc agagactgct cagagtgttt ccccggcgtg tcagaatctc aaccggtcgt     1980

cagaaagagg acgtatcgga aactctgtgc gattcatcat ctgctggggc gggctcccga     2040

gattgcttgc tcggcctgcg atctggtcaa cgtggacctg gatgactgtg tttctgagca     2100

ataaatgact taaaccaggt atggctgccg atggttatct tccagattgg ctcgaggaca     2160

acctctctga gggcattcgc gagtggtggg cgctgaaacc tggagccccg aagcccaaag     2220

ccaaccagca aaagcaggac gacggccggg gtctggtgct tcctggctac aagtacctcg     2280

gacccttcaa cggactcgac aagggggagc ccgtcaacgc ggcggacgca gcggccctcg     2340

agcacgacaa ggcctacgac cagcagctgc aggcgggtga caatccgtac ctgcggtata     2400

accacgccga cgccgagttt caggagcgtc tgcaagaaga tacgtctttt gggggcaacc     2460

tcgggcgagc agtcttccag gccaagaagc gggttctcga acctctcggt ctggttgagg     2520

aaggcgctaa gacggctcct ggaaagaaga gaccggtaga gccatcaccc cagcgttctc     2580

cagactcctc tacgggcatc ggcaagaaag gccaacagcc cgccagaaaa agactcaatt     2640

ttggtcagac tggcgactca gagtcagttc cagaccctca acctctcgga gaacctccag     2700

cagcgccctc tggtgtggga cctaatacaa tggctgcagg cggtggcgca ccaatggcag     2760

acaataacga aggcgccgac ggagtgggta gttcctcggg aaattggcat tgcgattcca     2820

catggctggg cgacagagtc atcaccacca gcacccgaac ctgggccctg cccacctaca     2880

acaaccacct ctacaagcaa atctccaacg ggacatcggg aggagccacc aacgacaaca     2940

cctacttcgg ctacagcacc ccctgggggt attttgactt taacagattc cactgccact     3000

tttcaccacg tgactggcag cgactcatca acaacaactg gggattccgg cccaagagac     3060

tcagcttcaa gctcttcaac atccaggtca aggaggtcac gcagaatgaa ggcaccaaga     3120

ccatcgccaa taacctcacc agcaccatcc aggtgtttac ggactcggag taccagctgc     3180

cgtacgttct cggctctgcc caccagggct gcctgcctcc gttcccggcg gacgtgttca     3240

tgattcccca gtacggctac ctaacactca acaacggtag tcaggccgtg ggacgctcct     3300

ccttctactg cctggaatac tttccttcgc agatgctgag aaccggcaac aacttccagt     3360

ttacttacac cttcgaggac gtgcctttcc acagcagcta cgcccacagc cagagcttgg     3420

accggctgat gaatcctctg attgaccagt acctgtacta cttgtctcgg actcaaacaa     3480

caggaggcac ggcaaatacg cagactctgg gcttcagcca aggtgggcct aatacaatgg     3540

ccaatcaggc aaagaactgg ctgccaggac cctgttaccg ccaacaacgc gtctcaacga     3600

caaccgggca aaacaacaat agcaactttg cctggactgc tgggaccaaa taccatctga     3660

atggaagaaa ttcattggct aatcctggca tcgctatggc aacacacaaa gacgacgagg     3720

agcgtttttt tcccagtaac gggatcctga tttttggcaa acaaaatgct gccagagaca     3780

atgcggatta cagcgatgtc atgctcacca gcgaggaaga aatcaaaacc actaaccctg     3840

tggctacaga ggaatacggt atcgtggcag ataacttgca gcagcaaaac acggctcctc     3900

aaattggaac tgtcaacagc cagggggcct tacccggtat ggtctggcag aaccgggacg     3960

tgtacctgca gggtcccatc tgggccaaga ttcctcacac ggacggcaac ttccacccgt     4020

ctccgctgat gggcggcttt ggcctgaaac atcctccgcc tcagatcctg atcaagaaca     4080

cgcctgtacc tgcggatcct ccgaccacct tcaaccagtc aaagctgaac tctttcatca     4140

cgcaatacag caccggacag gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca     4200

gcaagcgctg gaaccccgag atccagtaca cctccaacta ctacaaatct acaagtgtgg     4260

actttgctgt taatacagaa ggcgtgtact ctgaaccccg ccccattggc acccgttacc     4320

tcacccgtaa tctgtaattg cctgttaatc aataaaccgg ttgattcgtt tcagttgaac     4380

tttggtctct gcg                                                        4393


<210>  31
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SA EF1a splice acceptor

<400>  31
agtttttttc ttccatttca ggtgtcgtga aaactacccc t                           41


<210>  32
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SD mIGHJ1/J4 splice donor

<400>  32
ctcctcaggt aag                                                          13


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgHJ3 SD 98.84 splice donor

<400>  33
tgtctctgca ggtgagtcct aac                                               23


<210>  34
<211>  155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of IGH minimal promoter

<400>  34
ggtacctttt cattccttcc tctccagttc ttctctagat ggactaggtc cttaactagc       60

gaattcggat ccctgtctca tgaatatgca aatcaggtga gtccatggtg gtaaatatag      120

ggatgtcgac acacctcaca aacttaagat ctaga                                 155


<210>  35
<211>  314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgK Minimal Promoter

<400>  35
ggcttgtgcc aaacatcttc tgggtggatt taggtgattg aggagaagaa agacacagga       60

gcgaaattct ctgagcacaa gggaggagtt ctacactcag actgagccaa cagacttttc      120

tggcctgaca accagggcgg cgcaggatgc tcagtgcaga gaggaagaag caggtggtct      180

ttgcagctga aagctcagct cccaccccag ctgctttgca tgtccctccc agctgcccta      240

ccttccagag cccatatcaa tgcctgggtc agagctctgg ggaggaactg ctcagttagg      300

acccagacgg aacc                                                        314


<210>  36
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12-RSS


<220>
<221>  misc_feature
<222>  (8)..(19)
<223>  n is a, c, g, or t

<400>  36
cacagtgnnn nnnnnnnnna caaaaacc                                          28


<210>  37
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  23-RSS


<220>
<221>  misc_feature
<222>  (8)..(30)
<223>  n is a, c, g, or t

<400>  37
cacagtgnnn nnnnnnnnnn nnnnnnnnnn acaaaaacc                              39


<210>  38
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  22-RSS


<220>
<221>  misc_feature
<222>  (8)..(29)
<223>  n is a, c, g, or t

<400>  38
cacagtgnnn nnnnnnnnnn nnnnnnnnna caaaaacc                               38


<210>  39
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11-RSS


<220>
<221>  misc_feature
<222>  (8)..(18)
<223>  n is a, c, g, or t

<400>  39
cacagtgnnn nnnnnnnnac aaaaacc                                           27


<210>  40
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  13-RSS


<220>
<221>  misc_feature
<222>  (8)..(20)
<223>  n is a, c, g, or t

<400>  40
cacagtgnnn nnnnnnnnnn acaaaaacc                                         29


<210>  41
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  24-RSS


<220>
<221>  misc_feature
<222>  (8)..(31)
<223>  n is a, c, g, or t

<400>  41
cacagtgnnn nnnnnnnnnn nnnnnnnnnn nacaaaaacc                             40


<210>  42
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Line 1 of Fig 17A: IgK-V3-15 Sense strand, the Mouse IgK-J (any 
       of J1, J2, J4, J5, that may be any sequence denoted herein as N 
       for any nucleotide, in the middle block of line 1) and Mouse 
       IgK-Constant Sense strand


<220>
<221>  misc_feature
<222>  (38)..(76)
<223>  n is a, c, g, or t

<400>  42
cagtttatta ctgtcagcag tataataact ggcctccnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnngggc tgatgctgca ccaactgtat ccatcttc                   108


<210>  43
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Line 2 of Fig 17A: IgK-V3-15 anti-Sense strand, the Mouse IgK-J 
       (any of J1, J2, J4, J5, that may be any sequence denoted herein 
       as N for any nucleotide, in the middle block of line 1) and Mouse
       IgK-Constant Sense strand


<220>
<221>  misc_feature
<222>  (38)..(76)
<223>  n is a, c, g, or t

<400>  43
gtcaaataat gacagtcgtc atattattga ccggaggnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnncccg actacgacgt ggttgacata ggtagaag                   108


<210>  44
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Line 3 of Fig 17A: putative encoded amino acid sequence of the 
       IgK-V3-15, the Mouse IgK-J (any of J1, J2, J4, J5, that may be 
       any sequence denoted herein as X for any amino acid residue, in 
       the middle block of line 1) and Mouse IgK-Constant Sense strand


<220>
<221>  MISC_FEATURE
<222>  (14)..(26)
<223>  x is any amino acid residue

<400>  44

Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly 
            20                  25          


<210>  45
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Line 4 of Fig 17A: IgK-V3-15 Sense strand at the left block of 
       the figure

<400>  45
cagtttatta ctgtcagcag tataataact ggcct                                  35


<210>  46
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Line 4 of Fig 17A: Mouse IgK-Constant Sense strand at the right 
       block of the figure. also the left part of lines 5 and 6

<400>  46
gggctgatgc tgcaccaact gtatccatct tc                                     32


<210>  47
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Line 5 of Fig 17A: Left part of coding joint #1

<400>  47
cagtttatta ctgtcagcag tataataact ggcc                                   34


<210>  48
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Line 5 of Fig 17A: Middle part of coding joint #1

<400>  48
gctcacgttc ggtgctggga ccaagctgga gctgaaac                               38


<210>  49
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Line 6 of Fig 17A: Left part of coding joint #2

<400>  49
cagtttatta ctgtcagcag tataataact ggcctc                                 36


<210>  50
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Line 6 of Fig 17A: Middle part of coding joint #2

<400>  50
gcacgttcgg ctcggggaca aagttggaaa taaaac                                 36


<210>  51
<211>  314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgK "Minimal Promoter

<400>  51
ggcttgtgcc aaacatcttc tgggtggatt taggtgattg aggagaagaa agacacagga       60

gcgaaattct ctgagcacaa gggaggagtt ctacactcag actgagccaa cagacttttc      120

tggcctgaca accagggcgg cgcaggatgc tcagtgcaga gaggaagaag caggtggtct      180

ttgcagctga aagctcagct cccaccccag ctgctttgca tgtccctccc agctgcccta      240

ccttccagag cccatatcaa tgcctgggtc agagctctgg ggaggaactg ctcagttagg      300

acccagacgg aacc                                                        314


