                         SEQUENCE LISTING

<110>  St. Jude Children's Research Hospital
 
<120>  TUMOR SUPPRESSION BY MODULATION OF NON-CANONICAL AUTOPHAGY (LAP) 
       IN MYELOID CELLS

<130>  S88435 1170WO (0040.5)

<150>  62/487,195
<151>  2017-04-19

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  941
<212>  PRT
<213>  Mus musculus


<220>
<221>  Murine Rubicon
<222>  (1)..(941)

<400>  1

Met Arg Pro Glu Gly Ala Gly Met Asp Leu Gly Gly Gly Asp Gly Glu 
1               5                   10                  15      


Arg Leu Leu Glu Lys Ser Arg Arg Glu His Trp Gln Leu Leu Gly Asn 
            20                  25                  30          


Leu Lys Thr Thr Val Glu Gly Leu Val Ser Ala Asn Cys Pro Asn Val 
        35                  40                  45              


Trp Ser Lys Tyr Gly Gly Leu Glu Arg Leu Cys Arg Asp Met Gln Asn 
    50                  55                  60                  


Ile Leu Tyr His Gly Leu Ile His Asp Gln Val Cys Cys Arg Gln Ala 
65                  70                  75                  80  


Asp Tyr Trp Gln Phe Val Lys Asp Ile Arg Trp Leu Ser Pro His Ser 
                85                  90                  95      


Ala Leu His Val Glu Lys Phe Ile Ser Leu His Glu Ser Asp Gln Ser 
            100                 105                 110         


Asp Thr Asp Ser Val Ser Glu Arg Ala Val Ala Glu Leu Trp Leu Gln 
        115                 120                 125             


His Ser Leu Gln Cys His Cys Leu Ser Ala Gln Leu Arg Pro Leu Leu 
    130                 135                 140                 


Gly Asp Arg Gln Tyr Ile Arg Lys Phe Tyr Thr Glu Thr Ala Phe Leu 
145                 150                 155                 160 


Leu Ser Asp Ala His Val Thr Ala Met Leu Gln Cys Leu Glu Ala Val 
                165                 170                 175     


Glu Gln Asn Asn Pro Arg Leu Leu Ala Gln Ile Asp Ala Ser Met Phe 
            180                 185                 190         


Ala Arg Lys Gln Glu Ser Pro Leu Leu Val Thr Lys Ser Gln Ser Leu 
        195                 200                 205             


Thr Ala Leu Pro Gly Ser Thr Tyr Thr Pro Pro Ala Ser Tyr Ala Gln 
    210                 215                 220                 


His Ser Tyr Phe Gly Ser Ser Ser Ser Leu Gln Ser Met Pro Gln Ser 
225                 230                 235                 240 


Ser His Ser Ser Glu Arg Arg Ser Thr Ser Phe Ser Leu Ser Gly Pro 
                245                 250                 255     


Ser Trp Gln Pro Gln Glu Asp Arg Glu Cys Leu Ser Pro Ala Glu Thr 
            260                 265                 270         


Gln Thr Thr Pro Ala Pro Leu Pro Ser Asp Ser Thr Leu Ala Gln Asp 
        275                 280                 285             


Ser Pro Leu Thr Ala Gln Glu Met Ser Asp Ser Thr Leu Thr Ser Pro 
    290                 295                 300                 


Leu Glu Ala Ser Trp Val Ser Ser Gln Asn Asp Ser Pro Ser Asp Val 
305                 310                 315                 320 


Ser Glu Gly Pro Glu Tyr Leu Ala Ile Gly Asn Pro Ala Pro His Gly 
                325                 330                 335     


Arg Thr Ala Ser Cys Glu Ser His Ser Ser Asn Gly Glu Ser Ser Ser 
            340                 345                 350         


Ser His Leu Phe Ser Ser Ser Ser Ser Gln Lys Leu Glu Ser Ala Ala 
        355                 360                 365             


Ser Ser Leu Gly Asp Gln Glu Glu Gly Arg Gln Ser Gln Ala Gly Ser 
    370                 375                 380                 


Val Leu Arg Arg Ser Ser Phe Ser Glu Gly Gln Thr Ala Pro Val Ala 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser His Ile Arg Ser His Ser Asp Thr Asn Ile 
                405                 410                 415     


Ala Ser Arg Gly Ala Ala Glu Gly Gly Gln Tyr Leu Cys Ser Gly Glu 
            420                 425                 430         


Gly Met Phe Arg Arg Pro Ser Glu Gly Gln Ser Leu Ile Ser Tyr Leu 
        435                 440                 445             


Ser Glu Gln Asp Phe Gly Ser Cys Ala Asp Leu Glu Lys Glu Asn Ala 
    450                 455                 460                 


His Phe Ser Ile Ser Glu Ser Leu Ile Ala Ala Ile Glu Leu Met Lys 
465                 470                 475                 480 


Cys Asn Met Met Ser Gln Cys Leu Glu Glu Glu Glu Val Glu Glu Glu 
                485                 490                 495     


Asp Ser Asp Arg Glu Ile Gln Glu Leu Lys Gln Lys Ile Arg Leu Arg 
            500                 505                 510         


Arg Gln Gln Ile Arg Thr Lys Asn Leu Leu Pro Ala Tyr Arg Glu Thr 
        515                 520                 525             


Glu Asn Gly Ser Phe Arg Val Thr Ser Ser Ser Ser Gln Phe Ser Ser 
    530                 535                 540                 


Arg Asp Ser Thr Gln Leu Ser Glu Ser Gly Ser Ala Glu Asp Ala Asp 
545                 550                 555                 560 


Asp Leu Glu Ile Gln Asp Ala Asp Ile Arg Arg Ser Ala Val Ser Asn 
                565                 570                 575     


Gly Lys Ser Ser Phe Ser Gln Asn Leu Ser His Cys Phe Leu His Ser 
            580                 585                 590         


Thr Ser Ala Glu Ala Val Ala Met Gly Leu Leu Lys Gln Phe Glu Gly 
        595                 600                 605             


Met Gln Leu Pro Ala Ala Ser Glu Leu Glu Trp Leu Val Pro Glu His 
    610                 615                 620                 


Asp Ala Pro Gln Lys Leu Leu Pro Ile Pro Asp Ser Leu Pro Ile Ser 
625                 630                 635                 640 


Pro Asp Asp Gly Gln His Ala Asp Ile Tyr Lys Leu Arg Ile Arg Val 
                645                 650                 655     


Arg Gly Asn Leu Glu Trp Ala Pro Pro Arg Pro Gln Ile Ile Phe Asn 
            660                 665                 670         


Val His Pro Ala Pro Thr Arg Lys Ile Ala Val Ala Lys Gln Asn Tyr 
        675                 680                 685             


Arg Cys Ala Gly Cys Gly Ile Arg Thr Asp Pro Asp Tyr Ile Lys Arg 
    690                 695                 700                 


Leu Arg Tyr Cys Glu Tyr Leu Gly Lys Tyr Phe Cys Gln Cys Cys His 
705                 710                 715                 720 


Glu Asn Ala Gln Met Val Val Pro Ser Arg Ile Leu Arg Lys Trp Asp 
                725                 730                 735     


Phe Ser Lys Tyr Tyr Val Ser Asn Phe Ser Lys Asp Leu Leu Leu Lys 
            740                 745                 750         


Ile Trp Asn Asp Pro Leu Phe Asn Val Gln Asp Ile Asn Ser Ala Leu 
        755                 760                 765             


Tyr Arg Lys Val Lys Leu Leu Asn Gln Val Arg Leu Leu Arg Val Gln 
    770                 775                 780                 


Leu Tyr His Met Lys Asn Met Phe Lys Thr Cys Arg Leu Ala Lys Glu 
785                 790                 795                 800 


Leu Leu Asp Ser Phe Asp Val Val Pro Gly His Leu Thr Glu Asp Leu 
                805                 810                 815     


His Leu Tyr Ser Leu Ser Asp Leu Thr Ala Thr Lys Lys Gly Glu Leu 
            820                 825                 830         


Gly Pro Arg Leu Ala Glu Leu Thr Arg Ala Gly Ala Ala His Val Glu 
        835                 840                 845             


Arg Cys Met Leu Cys Gln Ala Lys Gly Phe Ile Cys Glu Phe Cys Gln 
    850                 855                 860                 


Asn Glu Glu Asp Val Ile Phe Pro Phe Glu Leu His Lys Cys Arg Thr 
865                 870                 875                 880 


Cys Glu Glu Cys Lys Ala Cys Tyr His Lys Thr Cys Phe Lys Ser Gly 
                885                 890                 895     


Arg Cys Pro Arg Cys Glu Arg Leu Gln Ala Arg Arg Glu Leu Leu Ala 
            900                 905                 910         


Lys Gln Ser Leu Glu Ser Tyr Leu Ser Asp Tyr Glu Glu Glu Pro Thr 
        915                 920                 925             


Glu Ala Leu Ala Leu Glu Ala Thr Val Leu Glu Thr Thr 
    930                 935                 940     


<210>  2
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Pro Glu Gly Ala Gly Met Glu Leu Gly Gly Gly Glu Glu Arg 
1               5                   10                  15      


Leu Pro Glu Glu Ser Arg Arg Glu His Trp Gln Leu Leu Gly Asn Leu 
            20                  25                  30          


Lys Thr Thr Val Glu Gly Leu Val Ser Thr Asn Ser Pro Asn Val Trp 
        35                  40                  45              


Ser Lys Tyr Gly Gly Leu Glu Arg Leu Cys Arg Asp Met Gln Ser Ile 
    50                  55                  60                  


Leu Tyr His Gly Leu Ile Arg Asp Gln Ala Cys Arg Arg Gln Thr Asp 
65                  70                  75                  80  


Tyr Trp Gln Phe Val Lys Asp Ile Arg Trp Leu Ser Pro His Ser Ala 
                85                  90                  95      


Leu His Val Glu Lys Phe Ile Ser Val His Glu Asn Asp Gln Ser Ser 
            100                 105                 110         


Ala Asp Gly Ala Ser Glu Arg Ala Val Ala Glu Leu Trp Leu Gln His 
        115                 120                 125             


Ser Leu Gln Tyr His Cys Leu Ser Ala Gln Leu Arg Pro Leu Leu Gly 
    130                 135                 140                 


Asp Arg Gln Tyr Ile Arg Lys Phe Tyr Thr Asp Ala Ala Phe Leu Leu 
145                 150                 155                 160 


Ser Asp Ala His Val Thr Ala Met Leu Gln Cys Leu Glu Ala Val Glu 
                165                 170                 175     


Gln Asn Asn Pro Arg Leu Leu Ala Gln Ile Asp Ala Ser Met Phe Ala 
            180                 185                 190         


Arg Lys His Glu Ser Pro Leu Leu Val Thr Lys Ser Gln Ser Leu Thr 
        195                 200                 205             


Ala Leu Pro Ser Ser Thr Tyr Thr Pro Pro Asn Ser Tyr Ala Gln His 
    210                 215                 220                 


Ser Tyr Phe Gly Ser Phe Ser Ser Leu His Gln Ser Val Pro Asn Asn 
225                 230                 235                 240 


Gly Ser Glu Arg Arg Ser Thr Ser Phe Pro Leu Ser Gly Pro Pro Arg 
                245                 250                 255     


Lys Pro Gln Glu Ser Arg Gly His Val Ser Pro Ala Glu Asp Gln Thr 
            260                 265                 270         


Ile Gln Ala Pro Pro Val Ser Val Ser Ala Leu Ala Arg Asp Ser Pro 
        275                 280                 285             


Leu Thr Pro Asn Glu Met Ser Ser Ser Thr Leu Thr Ser Pro Ile Glu 
    290                 295                 300                 


Ala Ser Trp Val Ser Ser Gln Asn Asp Ser Pro Gly Asp Ala Ser Glu 
305                 310                 315                 320 


Gly Pro Glu Tyr Leu Ala Ile Gly Asn Leu Asp Pro Arg Gly Arg Thr 
                325                 330                 335     


Ala Ser Cys Gln Ser His Ser Ser Asn Ala Glu Ser Ser Ser Ser Asn 
            340                 345                 350         


Leu Phe Ser Ser Ser Ser Ser Gln Lys Pro Asp Ser Ala Ala Ser Ser 
        355                 360                 365             


Leu Gly Asp Gln Glu Gly Gly Gly Glu Ser Gln Leu Ser Ser Val Leu 
    370                 375                 380                 


Arg Arg Ser Ser Phe Ser Glu Gly Gln Thr Leu Thr Val Thr Ser Gly 
385                 390                 395                 400 


Ala Lys Lys Ser His Ile Arg Ser His Ser Asp Thr Ser Ile Ala Ser 
                405                 410                 415     


Arg Gly Ala Pro Glu Ser Cys Asn Asp Lys Ala Lys Leu Arg Gly Pro 
            420                 425                 430         


Leu Pro Tyr Ser Gly Gln Ser Ser Glu Val Ser Thr Pro Ser Ser Leu 
        435                 440                 445             


Tyr Met Glu Tyr Glu Gly Gly Arg Tyr Leu Cys Ser Gly Glu Gly Met 
    450                 455                 460                 


Phe Arg Arg Pro Ser Glu Gly Gln Ser Leu Ile Ser Tyr Leu Ser Glu 
465                 470                 475                 480 


Gln Asp Phe Gly Ser Cys Ala Asp Leu Glu Lys Glu Asn Ala His Phe 
                485                 490                 495     


Ser Ile Ser Glu Ser Leu Ile Ala Ala Ile Glu Leu Met Lys Cys Asn 
            500                 505                 510         


Met Met Ser Gln Cys Leu Glu Glu Glu Glu Val Glu Glu Glu Asp Ser 
        515                 520                 525             


Asp Arg Glu Ile Gln Glu Leu Lys Gln Lys Ile Arg Leu Arg Arg Gln 
    530                 535                 540                 


Gln Ile Arg Thr Lys Asn Leu Leu Pro Met Tyr Gln Glu Ala Glu His 
545                 550                 555                 560 


Gly Ser Phe Arg Val Thr Ser Ser Ser Ser Gln Phe Ser Ser Arg Asp 
                565                 570                 575     


Ser Ala Gln Leu Ser Asp Ser Gly Ser Ala Asp Glu Val Asp Glu Phe 
            580                 585                 590         


Glu Ile Gln Asp Ala Asp Ile Arg Arg Asn Thr Ala Ser Ser Ser Lys 
        595                 600                 605             


Ser Phe Val Ser Ser Gln Ser Phe Ser His Cys Phe Leu His Ser Thr 
    610                 615                 620                 


Ser Ala Glu Ala Val Ala Met Gly Leu Leu Lys Gln Phe Glu Gly Met 
625                 630                 635                 640 


Gln Leu Pro Ala Ala Ser Glu Leu Glu Trp Leu Val Pro Glu His Asp 
                645                 650                 655     


Ala Pro Gln Lys Leu Leu Pro Ile Pro Asp Ser Leu Pro Ile Ser Pro 
            660                 665                 670         


Asp Asp Gly Gln His Ala Asp Ile Tyr Lys Leu Arg Ile Arg Val Arg 
        675                 680                 685             


Gly Asn Leu Glu Trp Ala Pro Pro Arg Pro Gln Ile Ile Phe Asn Val 
    690                 695                 700                 


His Pro Ala Pro Thr Arg Lys Ile Ala Val Ala Lys Gln Asn Tyr Arg 
705                 710                 715                 720 


Cys Ala Gly Cys Gly Ile Arg Thr Asp Pro Asp Tyr Ile Lys Arg Leu 
                725                 730                 735     


Arg Tyr Cys Glu Tyr Leu Gly Lys Tyr Phe Cys Gln Cys Cys His Glu 
            740                 745                 750         


Asn Ala Gln Met Ala Ile Pro Ser Arg Val Leu Arg Lys Trp Asp Phe 
        755                 760                 765             


Ser Lys Tyr Tyr Val Ser Asn Phe Ser Lys Asp Leu Leu Ile Lys Ile 
    770                 775                 780                 


Trp Asn Asp Pro Leu Phe Asn Val Gln Asp Ile Asn Ser Ala Leu Tyr 
785                 790                 795                 800 


Arg Lys Val Lys Leu Leu Asn Gln Val Arg Leu Leu Arg Val Gln Leu 
                805                 810                 815     


Cys His Met Lys Asn Met Phe Lys Thr Cys Arg Leu Ala Lys Glu Leu 
            820                 825                 830         


Leu Asp Ser Phe Asp Thr Val Pro Gly His Leu Thr Glu Asp Leu His 
        835                 840                 845             


Leu Tyr Ser Leu Asn Asp Leu Thr Ala Thr Arg Lys Gly Glu Leu Gly 
    850                 855                 860                 


Pro Arg Leu Ala Glu Leu Thr Arg Ala Gly Ala Thr His Val Glu Arg 
865                 870                 875                 880 


Cys Met Leu Cys Gln Ala Lys Gly Phe Ile Cys Glu Phe Cys Gln Asn 
                885                 890                 895     


Glu Asp Asp Ile Ile Phe Pro Phe Glu Leu His Lys Cys Arg Thr Cys 
            900                 905                 910         


Glu Glu Cys Lys Ala Cys Tyr His Lys Ala Cys Phe Lys Ser Gly Ser 
        915                 920                 925             


Cys Pro Arg Cys Glu Arg Leu Gln Ala Arg Arg Glu Ala Leu Ala Arg 
    930                 935                 940                 


Gln Ser Leu Glu Ser Tyr Leu Ser Asp Tyr Glu Glu Glu Pro Ala Glu 
945                 950                 955                 960 


Ala Leu Ala Leu Glu Ala Ala Val Leu Glu Ala Thr 
                965                 970         


<210>  3
<211>  570
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Human Nox2
<222>  (1)..(570)

<400>  3

Met Gly Asn Trp Ala Val Asn Glu Gly Leu Ser Ile Phe Val Ile Leu 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Trp Tyr Tyr Arg Val 
            20                  25                  30          


Tyr Asp Ile Pro Pro Lys Phe Phe Tyr Thr Arg Lys Leu Leu Gly Ser 
        35                  40                  45              


Ala Leu Ala Leu Ala Arg Ala Pro Ala Ala Cys Leu Asn Phe Asn Cys 
    50                  55                  60                  


Met Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Ser Ser Ala Cys Cys Ser Thr Arg Val Arg Arg Gln Leu Asp Arg 
                85                  90                  95      


Asn Leu Thr Phe His Lys Met Val Ala Trp Met Ile Ala Leu His Ser 
            100                 105                 110         


Ala Ile His Thr Ile Ala His Leu Phe Asn Val Glu Trp Cys Val Asn 
        115                 120                 125             


Ala Arg Val Asn Asn Ser Asp Pro Tyr Ser Val Ala Leu Ser Glu Leu 
    130                 135                 140                 


Gly Asp Arg Gln Asn Glu Ser Tyr Leu Asn Phe Ala Arg Lys Arg Ile 
145                 150                 155                 160 


Lys Asn Pro Glu Gly Gly Leu Tyr Leu Ala Val Thr Leu Leu Ala Gly 
                165                 170                 175     


Ile Thr Gly Val Val Ile Thr Leu Cys Leu Ile Leu Ile Ile Thr Ser 
            180                 185                 190         


Ser Thr Lys Thr Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr 
        195                 200                 205             


His His Leu Phe Val Ile Phe Phe Ile Gly Leu Ala Ile His Gly Ala 
    210                 215                 220                 


Glu Arg Ile Val Arg Gly Gln Thr Ala Glu Ser Leu Ala Val His Asn 
225                 230                 235                 240 


Ile Thr Val Cys Glu Gln Lys Ile Ser Glu Trp Gly Lys Ile Lys Glu 
                245                 250                 255     


Cys Pro Ile Pro Gln Phe Ala Gly Asn Pro Pro Met Thr Trp Lys Trp 
            260                 265                 270         


Ile Val Gly Pro Met Phe Leu Tyr Leu Cys Glu Arg Leu Val Arg Phe 
        275                 280                 285             


Trp Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Thr His Pro 
    290                 295                 300                 


Phe Lys Thr Ile Glu Leu Gln Met Lys Lys Lys Gly Phe Lys Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Lys Cys Pro Lys Val Ser Lys Leu Glu 
                325                 330                 335     


Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ile Val Gly Asp Trp Thr Glu Gly Leu Phe Asn Ala 
        355                 360                 365             


Cys Gly Cys Asp Lys Gln Glu Phe Gln Asp Ala Trp Lys Leu Pro Lys 
    370                 375                 380                 


Ile Ala Val Asp Gly Pro Phe Gly Thr Ala Ser Glu Asp Val Phe Ser 
385                 390                 395                 400 


Tyr Glu Val Val Met Leu Val Gly Ala Gly Ile Gly Val Thr Pro Phe 
                405                 410                 415     


Ala Ser Ile Leu Lys Ser Val Trp Tyr Lys Tyr Cys Asn Asn Ala Thr 
            420                 425                 430         


Asn Leu Lys Leu Lys Lys Ile Tyr Phe Tyr Trp Leu Cys Arg Asp Thr 
        435                 440                 445             


His Ala Phe Glu Trp Phe Ala Asp Leu Leu Gln Leu Leu Glu Ser Gln 
    450                 455                 460                 


Met Gln Glu Arg Asn Asn Ala Gly Phe Leu Ser Tyr Asn Ile Tyr Leu 
465                 470                 475                 480 


Thr Gly Trp Asp Glu Ser Gln Ala Asn His Phe Ala Val His His Asp 
                485                 490                 495     


Glu Glu Lys Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Leu Tyr Gly 
            500                 505                 510         


Arg Pro Asn Trp Asp Asn Glu Phe Lys Thr Ile Ala Ser Gln His Pro 
        515                 520                 525             


Asn Thr Arg Ile Gly Val Phe Leu Cys Gly Pro Glu Ala Leu Ala Glu 
    530                 535                 540                 


Thr Leu Ser Lys Gln Ser Ile Ser Asn Ser Glu Ser Gly Pro Arg Gly 
545                 550                 555                 560 


Val His Phe Ile Phe Asn Lys Glu Asn Phe 
                565                 570 


<210>  4
<211>  570
<212>  PRT
<213>  Mus musculus


<220>
<221>  Murine Nox2
<222>  (1)..(570)

<400>  4

Met Gly Asn Trp Ala Val Asn Glu Gly Leu Ser Ile Phe Val Ile Leu 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Ile Asn Tyr Tyr Lys Val 
            20                  25                  30          


Tyr Asp Asp Gly Pro Lys Tyr Asn Tyr Thr Arg Lys Leu Leu Gly Ser 
        35                  40                  45              


Ala Leu Ala Leu Ala Arg Ala Pro Ala Ala Cys Leu Asn Phe Asn Cys 
    50                  55                  60                  


Met Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Ser Ser Ala Cys Cys Ser Thr Arg Ile Arg Arg Gln Leu Asp Arg 
                85                  90                  95      


Asn Leu Thr Phe His Lys Met Val Ala Trp Met Ile Ala Leu His Thr 
            100                 105                 110         


Ala Ile His Thr Ile Ala His Leu Phe Asn Val Glu Trp Cys Val Asn 
        115                 120                 125             


Ala Arg Val Gly Ile Ser Asp Arg Tyr Ser Ile Ala Leu Ser Asp Ile 
    130                 135                 140                 


Gly Asp Asn Glu Asn Glu Glu Tyr Leu Asn Phe Ala Arg Glu Lys Ile 
145                 150                 155                 160 


Lys Asn Pro Glu Gly Gly Leu Tyr Val Ala Val Thr Arg Leu Ala Gly 
                165                 170                 175     


Ile Thr Gly Ile Val Ile Thr Leu Cys Leu Ile Leu Ile Ile Thr Ser 
            180                 185                 190         


Ser Thr Lys Thr Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr 
        195                 200                 205             


His His Leu Phe Val Ile Phe Phe Ile Gly Leu Ala Ile His Gly Ala 
    210                 215                 220                 


Glu Arg Ile Val Arg Gly Gln Thr Ala Glu Ser Leu Glu Glu His Asn 
225                 230                 235                 240 


Leu Asp Ile Cys Ala Asp Lys Ile Glu Glu Trp Gly Lys Ile Lys Glu 
                245                 250                 255     


Cys Pro Val Pro Lys Phe Ala Gly Asn Pro Pro Met Thr Trp Lys Trp 
            260                 265                 270         


Ile Val Gly Pro Met Phe Leu Tyr Leu Cys Glu Arg Leu Val Arg Phe 
        275                 280                 285             


Trp Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Thr His Pro 
    290                 295                 300                 


Phe Lys Thr Ile Glu Leu Gln Met Lys Lys Lys Gly Phe Lys Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Lys Cys Pro Lys Val Ser Lys Leu Glu 
                325                 330                 335     


Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ile Val Gly Asp Trp Thr Glu Gly Leu Phe Asn Ala 
        355                 360                 365             


Cys Gly Cys Asp Lys Gln Glu Phe Gln Asp Ala Trp Lys Leu Pro Lys 
    370                 375                 380                 


Ile Ala Val Asp Gly Pro Phe Gly Thr Ala Ser Glu Asp Val Phe Ser 
385                 390                 395                 400 


Tyr Glu Val Val Met Leu Val Gly Ala Gly Ile Gly Val Thr Pro Phe 
                405                 410                 415     


Ala Ser Ile Leu Lys Ser Val Trp Tyr Lys Tyr Cys Asp Asn Ala Thr 
            420                 425                 430         


Ser Leu Lys Leu Lys Lys Ile Tyr Phe Tyr Trp Leu Cys Arg Asp Thr 
        435                 440                 445             


His Ala Phe Glu Trp Phe Ala Asp Leu Leu Gln Leu Leu Glu Thr Gln 
    450                 455                 460                 


Met Gln Glu Arg Asn Asn Ala Asn Phe Leu Ser Tyr Asn Ile Tyr Leu 
465                 470                 475                 480 


Thr Gly Trp Asp Glu Ser Gln Ala Asn His Phe Ala Val His His Asp 
                485                 490                 495     


Glu Glu Lys Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Leu Tyr Gly 
            500                 505                 510         


Arg Pro Asn Trp Asp Asn Glu Phe Lys Thr Ile Ala Ser Glu His Pro 
        515                 520                 525             


Asn Thr Thr Ile Gly Val Phe Leu Cys Gly Pro Glu Ala Leu Ala Glu 
    530                 535                 540                 


Thr Leu Ser Lys Gln Ser Ile Ser Asn Ser Glu Ser Gly Pro Arg Gly 
545                 550                 555                 560 


Val His Phe Ile Phe Asn Lys Glu Asn Phe 
                565                 570 


<210>  5
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  GAPDH-F-primer
<222>  (1)..(21)

<400>  5
aggtcggtgt gaacggattt g                                                 21


<210>  6
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  GAPDH-R-primer
<222>  (1)..(23)

<400>  6
tgtagaccat gtagttgagg tca                                               23


<210>  7
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  IL-1beta-F-primer
<222>  (1)..(22)

<400>  7
gcaactgttc ctgaactcaa ct                                                22


<210>  8
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  IL-1beta-R-primer
<222>  (1)..(21)

<400>  8
atcttttggg gtccgtcaac t                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  TNF-alpha-F-primer
<222>  (1)..(21)

<400>  9
aggaggagtc tgcgaagaag a                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  TNF-alpha-R-primer
<222>  (1)..(21)

<400>  10
ggcagtggac catctaactc g                                                 21


<210>  11
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  TGF-beta-F-primer
<222>  (1)..(19)

<400>  11
ctcccgtggc ttctagtgc                                                    19


<210>  12
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  TGF-beta-R-primer
<222>  (1)..(22)

<400>  12
gccttagttt ggacaggatc tg                                                22


<210>  13
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  IL-10-F-primer
<222>  (1)..(21)

<400>  13
gctcttactg actggcatga g                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic


<220>
<221>  IL-10-R-primer
<222>  (1)..(20)

<400>  14
cgcagctcta ggagcatgtg                                                   20


