                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
       INSTITUT CURIE
       UNIVERSITE PARIS SUD 11
 
<120>  PEPTIDES, ESPECIALLY POLYPEPTIDES, PHAGE DISPLAY SCREENING METHOD
        AND ASSOCIATED MEANS, AND THEIR USES FOR RESEARCH AND BIOMEDICAL
        APPLICATIONS

<130>  B12691A JAZ-AFL-KN

<140>  PCT-EPXXXX-XXXXXX
<141>  2018-03-13

<150>  EP17305454.5
<151>  2017-04-20

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  69
<212>  PRT
<213>  Escherichia coli

<400>  1

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  2
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected among T, A or S

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is selected among D, E or N

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is selected among D, E or N

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is selected among D, E or N

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is selected among T, A or S

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is selected among D, E or N

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is selected among L, I or V

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is selected among F, Y, W or A

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is selected among T, A or S

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is selected among N, E or S

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa is selected among R, K or E

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa is selected among W, F, Y or A

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is selected among D, E or N

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa is selected among T, A or S

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa is selected among N, E, D or S

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa is selected among T, A or S

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  Xaa is selected among G, A or S

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Xaa is selected among G, A, S or T

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  Xaa is selected among F, L or Y

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Xaa is selected among T, A or S

<400>  2

Xaa Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Xaa 
1               5                   10                  15      


Xaa Xaa Thr Phe Xaa Val Lys Val Gly Asp Lys Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Xaa Xaa Xaa Cys His Asn Xaa Gly Xaa Xaa Xaa 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  3
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clones

<400>  3

Ser Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asn 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Trp Thr Glu 
            20                  25                  30          


Lys Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Ser Asn Ala Cys His Asn Gly Gly Ser Phe Ala 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  4
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA coding SEQ ID NO 3

<400>  4
tctcctgatt gtgtaactgg aaaggtggag tatacaaaat ataataacga cgacaccttt       60

actgttaaag tgggtgataa agaactgtgg actgaaaaat ggaaccttca gtctcttctt      120

ctcagtgcgc aaattacggg gatgactgta accattaaat ctaacgcatg tcataatggt      180

gggtcttttg cagaagttat ttttcgt                                          207


<210>  5
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  clones B12 - C03 - D12 - G05 - G11 - H11

<400>  5

Ser Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asn 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Trp Thr Glu 
            20                  25                  30          


Lys Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Ser Asn Ala Cys His Asn Gly Gly Ser Phe Ala 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  6
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding SEQ ID NO 5

<400>  6
gcacctgatt gtgtaactgg aaaggtggag tatacaaaat ataataacga cgacaccttt       60

tctgttaaag tgggtgataa agaactgtgg actgaaaaat ggaaccttca gtctcttctt      120

ctcagtgcgc aaattacggg gatgactgta accattaaaa ctaacgcatg tcataatggt      180

ggggcactgt ctgaagttat ttttcgt                                          207


<210>  7
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clones A06 - C06

<400>  7

Ser Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asn 
1               5                   10                  15      


Asp Asp Thr Phe Ser Val Lys Val Gly Asp Lys Glu Ile Tyr Thr Ser 
            20                  25                  30          


Lys Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Ser Asn Thr Cys His Asn Gly Gly Ala Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  8
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding SEQ ID NO 7

<400>  8
tctcctgatt gtgtaactgg aaaggtggag tatacaaaat ataataacga cgacaccttt       60

tctgttaaag tgggtgataa agaaatctac acttctaaat ggaaccttca gtctcttctt      120

ctcagtgcgc aaattacggg gatgactgta accattaaat ctaacacttg tcataatggt      180

ggggcatttt ctgaagttat ttttcgt                                          207


<210>  9
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  clone B02

<400>  9

Ser Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Glu Asp Thr Phe Ser Val Lys Val Gly Asp Lys Glu Val Trp Thr Asn 
            20                  25                  30          


Arg Cys Lys Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Ser Ser Cys His Asn Ala Gly Gly Leu Thr 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  10
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding SEQ ID NO 9

<400>  10
tctcctgatt gtgtaactgg aaaggtggag tatacaaaat ataatgacga agacaccttt       60

tctgttaaag tgggtgataa agaagtgtgg actaaccgtt gcaaacttca gtctcttctt      120

ctcagtgcgc aaattacggg gatgactgta accattaaaa cttcttcttg tcataatgca      180

gggggtttga ctgaagttat ttttcgt                                          207


<210>  11
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  clone B05

<400>  11

Ala Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asp Asn Thr Phe Ser Val Lys Val Gly Asp Lys Glu Leu Tyr Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ser Cys His Asn Gly Gly Gly Phe Ala 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  12
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding SEQ ID NO 11

<400>  12
gcacctgatt gtgtaactgg aaaggtggag tatacaaaat ataatgacga caacaccttt       60

tctgttaaag tgggtgataa agaactgtac actaaccgtt ggaaccttca gtctcttctt      120

ctcagtgcgc aaattacggg gatgactgta accattaaaa ctaactcttg tcataatggt      180

gggggttttg cagaagttat ttttcgt                                          207


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  13

Met Lys Lys Thr Leu Leu Ile Ala Ala Ser Leu Ser Phe Phe Ser Ala 
1               5                   10                  15      


Ser Ala Leu Ala 
            20  


<210>  14
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Concatenation of SEQ ID NO 1 and 13

<400>  14

Met Lys Lys Thr Leu Leu Ile Ala Ala Ser Leu Ser Phe Phe Ser Ala 
1               5                   10                  15      


Ser Ala Leu Ala Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr 
            20                  25                  30          


Lys Tyr Asn Asp Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu 
        35                  40                  45              


Leu Phe Thr Asn Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln 
    50                  55                  60                  


Ile Thr Gly Met Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly 
65                  70                  75                  80  


Gly Gly Phe Ser Glu Val Ile Phe Arg 
                85                  


<210>  15
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding SEQ ID NO 13

<400>  15
atgaaaaaaa cattattaat agctgcatcg ctttcatttt tttcagcaag tgcgctggcg       60


<210>  16
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary M13 pIII sequence

<400>  16

Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser Phe Thr 
1               5                   10                  15      


Asn Val Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr Ala Asn Tyr Glu 
            20                  25                  30          


Gly Cys Leu Trp Asn Ala Thr Gly Val Val Val Cys Thr Gly Asp Glu 
        35                  40                  45              


Thr Gln Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu Ala Ile Pro Glu 
    50                  55                  60                  


Asn Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
65                  70                  75                  80  


Glu Gly Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp Thr Pro Ile Pro 
                85                  90                  95      


Gly Tyr Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr Pro Pro Gly Thr 
            100                 105                 110         


Glu Gln Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu Glu Ser Gln Pro 
        115                 120                 125             


Leu Asn Thr Phe Met Phe Gln Asn Asn Arg Phe Arg Asn Arg Gln Gly 
    130                 135                 140                 


Ala Leu Thr Val Tyr Thr Gly Thr Val Thr Gln Gly Thr Asp Pro Val 
145                 150                 155                 160 


Lys Thr Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys Ala Met Tyr Asp 
                165                 170                 175     


Ala Tyr Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe His Ser Gly Phe 
            180                 185                 190         


Asn Glu Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln Ser Ser Asp Leu 
        195                 200                 205             


Pro Gln Pro Pro Val Asn Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly 
225                 230                 235                 240 


Gly Ser Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Asp Phe 
                245                 250                 255     


Asp Tyr Glu Lys Met Ala Asn Ala Asn Lys Gly Ala Met Thr Glu Asn 
            260                 265                 270         


Ala Asp Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly Lys Leu Asp Ser 
        275                 280                 285             


Val Ala Thr Asp Tyr Gly Ala Ala Asn Gly Asp Ala 
    290                 295                 300 


<210>  17
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Example of STxB - PIII fusion protein

<400>  17

Met Ala Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr 
1               5                   10                  15      


Asn Asp Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe 
            20                  25                  30          


Thr Asn Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr 
        35                  40                  45              


Gly Met Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly 
    50                  55                  60                  


Phe Ser Glu Val Ile Phe Arg Ala Ala Ala His His His His His His 
65                  70                  75                  80  


Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
                85                  90                  95      


Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Glu 
            100                 105                 110         


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Gln Thr Val 
        115                 120                 125             


Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser Phe Thr Asn Val 
    130                 135                 140                 


Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr Ala Asn Tyr Glu Gly Cys 
145                 150                 155                 160 


Leu Trp Asn Ala Thr Gly Val Val Val Cys Thr Gly Asp Glu Thr Gln 
                165                 170                 175     


Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu Ala Ile Pro Glu Asn Glu 
            180                 185                 190         


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
        195                 200                 205             


Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp Thr Pro Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr Pro Pro Gly Thr Glu Gln 
225                 230                 235                 240 


Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu Glu Ser Gln Pro Leu Asn 
                245                 250                 255     


Thr Phe Met Phe Gln Asn Asn Arg Phe Arg Asn Arg Gln Gly Ala Leu 
            260                 265                 270         


Thr Val Tyr Thr Gly Thr Val Thr Gln Gly Thr Asp Pro Val Lys Thr 
        275                 280                 285             


Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys Ala Met Tyr Asp Ala Tyr 
    290                 295                 300                 


Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe His Ser Gly Phe Asn Glu 
305                 310                 315                 320 


Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln Ser Ser Asp Leu Pro Gln 
                325                 330                 335     


Pro Pro Val Asn Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
        355                 360                 365             


Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Asp Phe Asp Tyr 
    370                 375                 380                 


Glu Lys Met Ala Asn Ala Asn Lys Gly Ala Met Thr Glu Asn Ala Asp 
385                 390                 395                 400 


Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly Lys Leu Asp Ser Val Ala 
                405                 410                 415     


Thr Asp Tyr Gly Ala Ala Asn Gly Asp Ala 
            420                 425     


<210>  18
<211>  1277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding SEQ ID NO 17

<400>  18
atggcgacgc ctgattgtgt aactggaaag gtggagtata caaaatataa tgatgacgat       60

acctttacgt taaagtgggt gataaagaat tatttaccaa cagatggaat cttcagtctc      120

ttcttctcag tgcgcaaatt acggggatga ctgtaaccat taaaactaat gcctgtcata      180

atggaggggg attcagcgaa gttatttttc gtgcggccgc acatcatcat caccatcacg      240

gggccgcgga acaaaaactc atctcagaag aggatctgaa tggggccgca gagcaaaagc      300

taatatctga agaagatctc aacggggccg cagaacagaa acttatcagt gaggaggact      360

tgaatggggc cgcatagact gttgaaagtt gtttagcaaa acctcataca gaaaattcat      420

ttactaacgt ctggaaagac gacaaaactc tagatcgtta cgctaactat gagggctgtc      480

tgtggaatgc tacaggcgtt gtggtttgta ctggtgacga aactcagtgt tacggtacat      540

gggttcctat tgggcttgct atccctgaaa atgagggtgg tggctctgag ggtggcggtt      600

ctgagggtgg cggttctgag ggtggcggta ctaaacctcc tgagtacggt gatacaccta      660

ttccgggcta tacttatatc aaccctctcg acggcactta tccgcctggt actgagcaaa      720

accccgctaa tcctaatcct tctcttgagg agtctcagcc tcttaatact ttcatgtttc      780

agaataatag gttccgaaat aggcagggtg cattaactgt ttatacgggc actgttactc      840

aaggcactga ccccgttaaa acttattacc agtacactcc tgtatcatca aaagccatgt      900

atgacgctta ctggaacggt aaattcagag actgcgcttt ccattctggc tttaatgagg      960

atccattcgt ttgtgaatat caaggccaat cgtctgacct gcctcaacct cctgtcaatg     1020

ctggcggcgg ctctggtggt ggttctggtg gcggctctga gggtggcggc tctgagggtg     1080

gcggttctga gggtggcggc tctgagggtg gcggttccgg tggcggctcc ggttccggtg     1140

attttgatta tgaaaaaatg gcaaacgcta ataagggggc tatgaccgaa aatgccgatg     1200

aaaacgcgct acagtctgac gctaaaggca aacttgattc tgtcgctact gattacggtg     1260

ctgctaatgg cgacgcc                                                    1277


<210>  19
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding pIII fragment

<400>  19
actgttgaaa gttgtttagc aaaacctcat acagaaaatt catttactaa cgtctggaaa       60

gacgacaaaa ctctagatcg ttacgctaac tatgagggct gtctgtggaa tgctacaggc      120

gttgtggttt gtactggtga cgaaactcag tgttacggta catgggttcc tattgggctt      180

gctatccctg aaaatgaggg tggtggctct gagggtggcg gttctgaggg tggcggttct      240

gagggtggcg gtactaaacc tcctgagtac ggtgatacac ctattccggg ctatacttat      300

atcaaccctc tcgacggcac ttatccgcct ggtactgagc aaaaccccgc taatcctaat      360

ccttctcttg aggagtctca gcctcttaat actttcatgt ttcagaataa taggttccga      420

aataggcagg gtgcattaac tgtttatacg ggcactgtta ctcaaggcac tgaccccgtt      480

aaaacttatt accagtacac tcctgtatca tcaaaagcca tgtatgacgc ttactggaac      540

ggtaaattca gagactgcgc tttccattct ggctttaatg aggatccatt cgtttgtgaa      600

tatcaaggcc aatcgtctga cctgcctcaa cctcctgtca atgctggcgg cggctctggt      660

ggtggttctg gtggcggctc tgagggtggc ggctctgagg gtggcggttc tgagggtggc      720

ggctctgagg gtggcggttc cggtggcggc tccggttccg gtgattttga ttatgaaaaa      780

atggcaaacg ctaataaggg ggctatgacc gaaaatgccg atgaaaacgc gctacagtct      840

gacgctaaag gcaaacttga ttctgtcgct actgattacg gtgctgctaa tggcgacgcc      900

tga                                                                    903


<210>  20
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A3 - D10 - H3 - pIII fusion

<400>  20

Met Ala Ser Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr 
1               5                   10                  15      


Asn Asn Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Trp 
            20                  25                  30          


Thr Glu Lys Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr 
        35                  40                  45              


Gly Met Thr Val Thr Ile Lys Ser Asn Ala Cys His Asn Gly Gly Ser 
    50                  55                  60                  


Phe Ala Glu Val Ile Phe Arg Ala Ala Ala His His His His His His 
65                  70                  75                  80  


Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
                85                  90                  95      


Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Glu 
            100                 105                 110         


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Gln Thr Val 
        115                 120                 125             


Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser Phe Thr Asn Val 
    130                 135                 140                 


Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr Ala Asn Tyr Glu Gly Cys 
145                 150                 155                 160 


Leu Trp Asn Ala Thr Gly Val Val Val Cys Thr Gly Asp Glu Thr Gln 
                165                 170                 175     


Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu Ala Ile Pro Glu Asn Glu 
            180                 185                 190         


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
        195                 200                 205             


Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp Thr Pro Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr Pro Pro Gly Thr Glu Gln 
225                 230                 235                 240 


Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu Glu Ser Gln Pro Leu Asn 
                245                 250                 255     


Thr Phe Met Phe Gln Asn Asn Arg Phe Arg Asn Arg Gln Gly Ala Leu 
            260                 265                 270         


Thr Val Tyr Thr Gly Thr Val Thr Gln Gly Thr Asp Pro Val Lys Thr 
        275                 280                 285             


Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys Ala Met Tyr Asp Ala Tyr 
    290                 295                 300                 


Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe His Ser Gly Phe Asn Glu 
305                 310                 315                 320 


Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln Ser Ser Asp Leu Pro Gln 
                325                 330                 335     


Pro Pro Val Asn Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
        355                 360                 365             


Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Asp Phe Asp Tyr 
    370                 375                 380                 


Glu Lys Met Ala Asn Ala Asn Lys Gly Ala Met Thr Glu Asn Ala Asp 
385                 390                 395                 400 


Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly Lys Leu Asp Ser Val Ala 
                405                 410                 415     


Thr Asp Tyr Gly Ala Ala Asn Gly Asp Ala 
            420                 425     


<210>  21
<211>  1281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding A3 - D10 - H3 - pIII fusion

<400>  21
atggcgtctc ctgattgtgt aactggaaag gtggagtata caaaatataa taacgacgac       60

acctttactg ttaaagtggg tgataaagaa ctgtggactg aaaaatggaa ccttcagtct      120

cttcttctca gtgcgcaaat tacggggatg actgtaacca ttaaatctaa cgcatgtcat      180

aatggtgggt cttttgcaga agttattttt cgtgcggccg cacatcatca tcaccatcac      240

ggggccgcgg aacaaaaact catctcagaa gaggatctga atggggccgc agagcaaaag      300

ctaatatctg aagaagatct caacggggcc gcagaacaga aacttatcag tgaggaggac      360

ttgaatgggg ccgcatagac tgttgaaagt tgtttagcaa aacctcatac agaaaattca      420

tttactaacg tctggaaaga cgacaaaact ctagatcgtt acgctaacta tgagggctgt      480

ctgtggaatg ctacaggcgt tgtggtttgt actggtgacg aaactcagtg ttacggtaca      540

tgggttccta ttgggcttgc tatccctgaa aatgagggtg gtggctctga gggtggcggt      600

tctgagggtg gcggttctga gggtggcggt actaaacctc ctgagtacgg tgatacacct      660

attccgggct atacttatat caaccctctc gacggcactt atccgcctgg tactgagcaa      720

aaccccgcta atcctaatcc ttctcttgag gagtctcagc ctcttaatac tttcatgttt      780

cagaataata ggttccgaaa taggcagggt gcattaactg tttatacggg cactgttact      840

caaggcactg accccgttaa aacttattac cagtacactc ctgtatcatc aaaagccatg      900

tatgacgctt actggaacgg taaattcaga gactgcgctt tccattctgg ctttaatgag      960

gatccattcg tttgtgaata tcaaggccaa tcgtctgacc tgcctcaacc tcctgtcaat     1020

gctggcggcg gctctggtgg tggttctggt ggcggctctg agggtggcgg ctctgagggt     1080

ggcggttctg agggtggcgg ctctgagggt ggcggttccg gtggcggctc cggttccggt     1140

gattttgatt atgaaaaaat ggcaaacgct aataaggggg ctatgaccga aaatgccgat     1200

gaaaacgcgc tacagtctga cgctaaaggc aaacttgatt ctgtcgctac tgattacggt     1260

gctgctaatg gcgacgcctg a                                               1281


<210>  22
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B12 - C03 - D12 - G05 - G11 - H11 - pIII fusion

<400>  22

Met Ala Ala Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr 
1               5                   10                  15      


Asn Asn Asp Asp Thr Phe Ser Val Lys Val Gly Asp Lys Glu Leu Trp 
            20                  25                  30          


Thr Glu Lys Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr 
        35                  40                  45              


Gly Met Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Ala 
    50                  55                  60                  


Leu Ser Glu Val Ile Phe Arg Ala Ala Ala His His His His His His 
65                  70                  75                  80  


Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
                85                  90                  95      


Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Glu 
            100                 105                 110         


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Gln Thr Val 
        115                 120                 125             


Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser Phe Thr Asn Val 
    130                 135                 140                 


Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr Ala Asn Tyr Glu Gly Cys 
145                 150                 155                 160 


Leu Trp Asn Ala Thr Gly Val Val Val Cys Thr Gly Asp Glu Thr Gln 
                165                 170                 175     


Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu Ala Ile Pro Glu Asn Glu 
            180                 185                 190         


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
        195                 200                 205             


Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp Thr Pro Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr Pro Pro Gly Thr Glu Gln 
225                 230                 235                 240 


Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu Glu Ser Gln Pro Leu Asn 
                245                 250                 255     


Thr Phe Met Phe Gln Asn Asn Arg Phe Arg Asn Arg Gln Gly Ala Leu 
            260                 265                 270         


Thr Val Tyr Thr Gly Thr Val Thr Gln Gly Thr Asp Pro Val Lys Thr 
        275                 280                 285             


Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys Ala Met Tyr Asp Ala Tyr 
    290                 295                 300                 


Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe His Ser Gly Phe Asn Glu 
305                 310                 315                 320 


Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln Ser Ser Asp Leu Pro Gln 
                325                 330                 335     


Pro Pro Val Asn Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
        355                 360                 365             


Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Asp Phe Asp Tyr 
    370                 375                 380                 


Glu Lys Met Ala Asn Ala Asn Lys Gly Ala Met Thr Glu Asn Ala Asp 
385                 390                 395                 400 


Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly Lys Leu Asp Ser Val Ala 
                405                 410                 415     


Thr Asp Tyr Gly Ala Ala Asn Gly Asp Ala 
            420                 425     


<210>  23
<211>  1281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding B12 - C03 - D12 - G05 - G11 - H11 - pIII fusion

<400>  23
atggcggcac ctgattgtgt aactggaaag gtggagtata caaaatataa taacgacgac       60

accttttctg ttaaagtggg tgataaagaa ctgtggactg aaaaatggaa ccttcagtct      120

cttcttctca gtgcgcaaat tacggggatg actgtaacca ttaaaactaa cgcatgtcat      180

aatggtgggg cactgtctga agttattttt cgtgcggccg cacatcatca tcaccatcac      240

ggggccgcgg aacaaaaact catctcagaa gaggatctga atggggccgc agagcaaaag      300

ctaatatctg aagaagatct caacggggcc gcagaacaga aacttatcag tgaggaggac      360

ttgaatgggg ccgcatagac tgttgaaagt tgtttagcaa aacctcatac agaaaattca      420

tttactaacg tctggaaaga cgacaaaact ctagatcgtt acgctaacta tgagggctgt      480

ctgtggaatg ctacaggcgt tgtggtttgt actggtgacg aaactcagtg ttacggtaca      540

tgggttccta ttgggcttgc tatccctgaa aatgagggtg gtggctctga gggtggcggt      600

tctgagggtg gcggttctga gggtggcggt actaaacctc ctgagtacgg tgatacacct      660

attccgggct atacttatat caaccctctc gacggcactt atccgcctgg tactgagcaa      720

aaccccgcta atcctaatcc ttctcttgag gagtctcagc ctcttaatac tttcatgttt      780

cagaataata ggttccgaaa taggcagggt gcattaactg tttatacggg cactgttact      840

caaggcactg accccgttaa aacttattac cagtacactc ctgtatcatc aaaagccatg      900

tatgacgctt actggaacgg taaattcaga gactgcgctt tccattctgg ctttaatgag      960

gatccattcg tttgtgaata tcaaggccaa tcgtctgacc tgcctcaacc tcctgtcaat     1020

gctggcggcg gctctggtgg tggttctggt ggcggctctg agggtggcgg ctctgagggt     1080

ggcggttctg agggtggcgg ctctgagggt ggcggttccg gtggcggctc cggttccggt     1140

gattttgatt atgaaaaaat ggcaaacgct aataaggggg ctatgaccga aaatgccgat     1200

gaaaacgcgc tacagtctga cgctaaaggc aaacttgatt ctgtcgctac tgattacggt     1260

gctgctaatg gcgacgcctg a                                               1281


<210>  24
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A06 - C06 - pIII fusion

<400>  24

Met Ala Ser Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr 
1               5                   10                  15      


Asn Asn Asp Asp Thr Phe Ser Val Lys Val Gly Asp Lys Glu Ile Tyr 
            20                  25                  30          


Thr Ser Lys Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr 
        35                  40                  45              


Gly Met Thr Val Thr Ile Lys Ser Asn Thr Cys His Asn Gly Gly Ala 
    50                  55                  60                  


Phe Ser Glu Val Ile Phe Arg Ala Ala Ala His His His His His His 
65                  70                  75                  80  


Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
                85                  90                  95      


Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Glu 
            100                 105                 110         


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Gln Thr Val 
        115                 120                 125             


Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser Phe Thr Asn Val 
    130                 135                 140                 


Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr Ala Asn Tyr Glu Gly Cys 
145                 150                 155                 160 


Leu Trp Asn Ala Thr Gly Val Val Val Cys Thr Gly Asp Glu Thr Gln 
                165                 170                 175     


Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu Ala Ile Pro Glu Asn Glu 
            180                 185                 190         


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
        195                 200                 205             


Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp Thr Pro Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr Pro Pro Gly Thr Glu Gln 
225                 230                 235                 240 


Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu Glu Ser Gln Pro Leu Asn 
                245                 250                 255     


Thr Phe Met Phe Gln Asn Asn Arg Phe Arg Asn Arg Gln Gly Ala Leu 
            260                 265                 270         


Thr Val Tyr Thr Gly Thr Val Thr Gln Gly Thr Asp Pro Val Lys Thr 
        275                 280                 285             


Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys Ala Met Tyr Asp Ala Tyr 
    290                 295                 300                 


Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe His Ser Gly Phe Asn Glu 
305                 310                 315                 320 


Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln Ser Ser Asp Leu Pro Gln 
                325                 330                 335     


Pro Pro Val Asn Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
        355                 360                 365             


Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Asp Phe Asp Tyr 
    370                 375                 380                 


Glu Lys Met Ala Asn Ala Asn Lys Gly Ala Met Thr Glu Asn Ala Asp 
385                 390                 395                 400 


Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly Lys Leu Asp Ser Val Ala 
                405                 410                 415     


Thr Asp Tyr Gly Ala Ala Asn Gly Asp Ala 
            420                 425     


<210>  25
<211>  1281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding A06 - C06 - pIII fusion

<400>  25
atggcgtctc ctgattgtgt aactggaaag gtggagtata caaaatataa taacgacgac       60

accttttctg ttaaagtggg tgataaagaa atctacactt ctaaatggaa ccttcagtct      120

cttcttctca gtgcgcaaat tacggggatg actgtaacca ttaaatctaa cacttgtcat      180

aatggtgggg cattttctga agttattttt cgtgcggccg cacatcatca tcaccatcac      240

ggggccgcgg aacaaaaact catctcagaa gaggatctga atggggccgc agagcaaaag      300

ctaatatctg aagaagatct caacggggcc gcagaacaga aacttatcag tgaggaggac      360

ttgaatgggg ccgcatagac tgttgaaagt tgtttagcaa aacctcatac agaaaattca      420

tttactaacg tctggaaaga cgacaaaact ctagatcgtt acgctaacta tgagggctgt      480

ctgtggaatg ctacaggcgt tgtggtttgt actggtgacg aaactcagtg ttacggtaca      540

tgggttccta ttgggcttgc tatccctgaa aatgagggtg gtggctctga gggtggcggt      600

tctgagggtg gcggttctga gggtggcggt actaaacctc ctgagtacgg tgatacacct      660

attccgggct atacttatat caaccctctc gacggcactt atccgcctgg tactgagcaa      720

aaccccgcta atcctaatcc ttctcttgag gagtctcagc ctcttaatac tttcatgttt      780

cagaataata ggttccgaaa taggcagggt gcattaactg tttatacggg cactgttact      840

caaggcactg accccgttaa aacttattac cagtacactc ctgtatcatc aaaagccatg      900

tatgacgctt actggaacgg taaattcaga gactgcgctt tccattctgg ctttaatgag      960

gatccattcg tttgtgaata tcaaggccaa tcgtctgacc tgcctcaacc tcctgtcaat     1020

gctggcggcg gctctggtgg tggttctggt ggcggctctg agggtggcgg ctctgagggt     1080

ggcggttctg agggtggcgg ctctgagggt ggcggttccg gtggcggctc cggttccggt     1140

gattttgatt atgaaaaaat ggcaaacgct aataaggggg ctatgaccga aaatgccgat     1200

gaaaacgcgc tacagtctga cgctaaaggc aaacttgatt ctgtcgctac tgattacggt     1260

gctgctaatg gcgacgcctg a                                               1281


<210>  26
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B02 - pIII fusion

<400>  26

Met Ala Ser Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr 
1               5                   10                  15      


Asn Asp Glu Asp Thr Phe Ser Val Lys Val Gly Asp Lys Glu Val Trp 
            20                  25                  30          


Thr Asn Arg Cys Lys Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr 
        35                  40                  45              


Gly Met Thr Val Thr Ile Lys Thr Ser Ser Cys His Asn Ala Gly Gly 
    50                  55                  60                  


Leu Thr Glu Val Ile Phe Arg Ala Ala Ala His His His His His His 
65                  70                  75                  80  


Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
                85                  90                  95      


Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Glu 
            100                 105                 110         


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Gln Thr Val 
        115                 120                 125             


Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser Phe Thr Asn Val 
    130                 135                 140                 


Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr Ala Asn Tyr Glu Gly Cys 
145                 150                 155                 160 


Leu Trp Asn Ala Thr Gly Val Val Val Cys Thr Gly Asp Glu Thr Gln 
                165                 170                 175     


Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu Ala Ile Pro Glu Asn Glu 
            180                 185                 190         


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
        195                 200                 205             


Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp Thr Pro Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr Pro Pro Gly Thr Glu Gln 
225                 230                 235                 240 


Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu Glu Ser Gln Pro Leu Asn 
                245                 250                 255     


Thr Phe Met Phe Gln Asn Asn Arg Phe Arg Asn Arg Gln Gly Ala Leu 
            260                 265                 270         


Thr Val Tyr Thr Gly Thr Val Thr Gln Gly Thr Asp Pro Val Lys Thr 
        275                 280                 285             


Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys Ala Met Tyr Asp Ala Tyr 
    290                 295                 300                 


Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe His Ser Gly Phe Asn Glu 
305                 310                 315                 320 


Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln Ser Ser Asp Leu Pro Gln 
                325                 330                 335     


Pro Pro Val Asn Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
        355                 360                 365             


Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Asp Phe Asp Tyr 
    370                 375                 380                 


Glu Lys Met Ala Asn Ala Asn Lys Gly Ala Met Thr Glu Asn Ala Asp 
385                 390                 395                 400 


Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly Lys Leu Asp Ser Val Ala 
                405                 410                 415     


Thr Asp Tyr Gly Ala Ala Asn Gly Asp Ala 
            420                 425     


<210>  27
<211>  1281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding B02 - pIII fusion

<400>  27
atggcgtctc ctgattgtgt aactggaaag gtggagtata caaaatataa tgacgaagac       60

accttttctg ttaaagtggg tgataaagaa gtgtggacta accgttgcaa acttcagtct      120

cttcttctca gtgcgcaaat tacggggatg actgtaacca ttaaaacttc ttcttgtcat      180

aatgcagggg gtttgactga agttattttt cgtgcggccg cacatcatca tcaccatcac      240

ggggccgcgg aacaaaaact catctcagaa gaggatctga atggggccgc agagcaaaag      300

ctaatatctg aagaagatct caacggggcc gcagaacaga aacttatcag tgaggaggac      360

ttgaatgggg ccgcatagac tgttgaaagt tgtttagcaa aacctcatac agaaaattca      420

tttactaacg tctggaaaga cgacaaaact ctagatcgtt acgctaacta tgagggctgt      480

ctgtggaatg ctacaggcgt tgtggtttgt actggtgacg aaactcagtg ttacggtaca      540

tgggttccta ttgggcttgc tatccctgaa aatgagggtg gtggctctga gggtggcggt      600

tctgagggtg gcggttctga gggtggcggt actaaacctc ctgagtacgg tgatacacct      660

attccgggct atacttatat caaccctctc gacggcactt atccgcctgg tactgagcaa      720

aaccccgcta atcctaatcc ttctcttgag gagtctcagc ctcttaatac tttcatgttt      780

cagaataata ggttccgaaa taggcagggt gcattaactg tttatacggg cactgttact      840

caaggcactg accccgttaa aacttattac cagtacactc ctgtatcatc aaaagccatg      900

tatgacgctt actggaacgg taaattcaga gactgcgctt tccattctgg ctttaatgag      960

gatccattcg tttgtgaata tcaaggccaa tcgtctgacc tgcctcaacc tcctgtcaat     1020

gctggcggcg gctctggtgg tggttctggt ggcggctctg agggtggcgg ctctgagggt     1080

ggcggttctg agggtggcgg ctctgagggt ggcggttccg gtggcggctc cggttccggt     1140

gattttgatt atgaaaaaat ggcaaacgct aataaggggg ctatgaccga aaatgccgat     1200

gaaaacgcgc tacagtctga cgctaaaggc aaacttgatt ctgtcgctac tgattacggt     1260

gctgctaatg gcgacgcctg a                                               1281


<210>  28
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B05 - pIII fusion

<400>  28

Met Ala Ala Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr 
1               5                   10                  15      


Asn Asp Asp Asn Thr Phe Ser Val Lys Val Gly Asp Lys Glu Leu Tyr 
            20                  25                  30          


Thr Asn Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr 
        35                  40                  45              


Gly Met Thr Val Thr Ile Lys Thr Asn Ser Cys His Asn Gly Gly Gly 
    50                  55                  60                  


Phe Ala Glu Val Ile Phe Arg Ala Ala Ala His His His His His His 
65                  70                  75                  80  


Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
                85                  90                  95      


Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Glu 
            100                 105                 110         


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Gln Thr Val 
        115                 120                 125             


Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser Phe Thr Asn Val 
    130                 135                 140                 


Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr Ala Asn Tyr Glu Gly Cys 
145                 150                 155                 160 


Leu Trp Asn Ala Thr Gly Val Val Val Cys Thr Gly Asp Glu Thr Gln 
                165                 170                 175     


Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu Ala Ile Pro Glu Asn Glu 
            180                 185                 190         


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
        195                 200                 205             


Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp Thr Pro Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr Pro Pro Gly Thr Glu Gln 
225                 230                 235                 240 


Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu Glu Ser Gln Pro Leu Asn 
                245                 250                 255     


Thr Phe Met Phe Gln Asn Asn Arg Phe Arg Asn Arg Gln Gly Ala Leu 
            260                 265                 270         


Thr Val Tyr Thr Gly Thr Val Thr Gln Gly Thr Asp Pro Val Lys Thr 
        275                 280                 285             


Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys Ala Met Tyr Asp Ala Tyr 
    290                 295                 300                 


Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe His Ser Gly Phe Asn Glu 
305                 310                 315                 320 


Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln Ser Ser Asp Leu Pro Gln 
                325                 330                 335     


Pro Pro Val Asn Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
        355                 360                 365             


Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Asp Phe Asp Tyr 
    370                 375                 380                 


Glu Lys Met Ala Asn Ala Asn Lys Gly Ala Met Thr Glu Asn Ala Asp 
385                 390                 395                 400 


Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly Lys Leu Asp Ser Val Ala 
                405                 410                 415     


Thr Asp Tyr Gly Ala Ala Asn Gly Asp Ala 
            420                 425     


<210>  29
<211>  1281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding B05 - pIII fusion

<400>  29
atggcggcac ctgattgtgt aactggaaag gtggagtata caaaatataa tgacgacaac       60

accttttctg ttaaagtggg tgataaagaa ctgtacacta accgttggaa ccttcagtct      120

cttcttctca gtgcgcaaat tacggggatg actgtaacca ttaaaactaa ctcttgtcat      180

aatggtgggg gttttgcaga agttattttt cgtgcggccg cacatcatca tcaccatcac      240

ggggccgcgg aacaaaaact catctcagaa gaggatctga atggggccgc agagcaaaag      300

ctaatatctg aagaagatct caacggggcc gcagaacaga aacttatcag tgaggaggac      360

ttgaatgggg ccgcatagac tgttgaaagt tgtttagcaa aacctcatac agaaaattca      420

tttactaacg tctggaaaga cgacaaaact ctagatcgtt acgctaacta tgagggctgt      480

ctgtggaatg ctacaggcgt tgtggtttgt actggtgacg aaactcagtg ttacggtaca      540

tgggttccta ttgggcttgc tatccctgaa aatgagggtg gtggctctga gggtggcggt      600

tctgagggtg gcggttctga gggtggcggt actaaacctc ctgagtacgg tgatacacct      660

attccgggct atacttatat caaccctctc gacggcactt atccgcctgg tactgagcaa      720

aaccccgcta atcctaatcc ttctcttgag gagtctcagc ctcttaatac tttcatgttt      780

cagaataata ggttccgaaa taggcagggt gcattaactg tttatacggg cactgttact      840

caaggcactg accccgttaa aacttattac cagtacactc ctgtatcatc aaaagccatg      900

tatgacgctt actggaacgg taaattcaga gactgcgctt tccattctgg ctttaatgag      960

gatccattcg tttgtgaata tcaaggccaa tcgtctgacc tgcctcaacc tcctgtcaat     1020

gctggcggcg gctctggtgg tggttctggt ggcggctctg agggtggcgg ctctgagggt     1080

ggcggttctg agggtggcgg ctctgagggt ggcggttccg gtggcggctc cggttccggt     1140

gattttgatt atgaaaaaat ggcaaacgct aataaggggg ctatgaccga aaatgccgat     1200

gaaaacgcgc tacagtctga cgctaaaggc aaacttgatt ctgtcgctac tgattacggt     1260

gctgctaatg gcgacgcctg a                                               1281


<210>  30
<211>  207
<212>  DNA
<213>  Escherichia coli

<400>  30
acgcctgatt gtgtaactgg aaaggtggag tatacaaaat ataatgatga cgataccttt       60

acagttaaag tgggtgataa agaattattt accaacagat ggaatcttca gtctcttctt      120

ctcagtgcgc aaattacggg gatgactgta accattaaaa ctaatgcctg tcataatgga      180

gggggattca gcgaagttat ttttcgt                                          207


<210>  31
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding STxB D18E, G62T mutant of SEQ ID 
       NO 32

<400>  31
acgcctgatt gtgtaactgg aaaggtggag tatacaaaat ataatgatga agataccttt       60

acagttaaag tgggtgataa agaattattt accaacagat ggaatcttca gtctcttctt      120

ctcagtgcgc aaattacggg gatgactgta accattaaaa ctaatgcctg tcataatgga      180

gggacattca gcgaagttat ttttcgt                                          207


<210>  32
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STxB D18E, G62T mutant sequence

<400>  32

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Glu Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Thr Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  33
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STxB mutant of SEQ ID NO 31 fused to pIII

<400>  33

Met Ala Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr 
1               5                   10                  15      


Asn Asp Glu Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe 
            20                  25                  30          


Thr Asn Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr 
        35                  40                  45              


Gly Met Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Thr 
    50                  55                  60                  


Phe Ser Glu Val Ile Phe Arg Ala Ala Ala His His His His His His 
65                  70                  75                  80  


Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
                85                  90                  95      


Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Glu 
            100                 105                 110         


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala Gln Thr Val 
        115                 120                 125             


Glu Ser Cys Leu Ala Lys Pro His Thr Glu Asn Ser Phe Thr Asn Val 
    130                 135                 140                 


Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr Ala Asn Tyr Glu Gly Cys 
145                 150                 155                 160 


Leu Trp Asn Ala Thr Gly Val Val Val Cys Thr Gly Asp Glu Thr Gln 
                165                 170                 175     


Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu Ala Ile Pro Glu Asn Glu 
            180                 185                 190         


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
        195                 200                 205             


Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp Thr Pro Ile Pro Gly Tyr 
    210                 215                 220                 


Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr Pro Pro Gly Thr Glu Gln 
225                 230                 235                 240 


Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu Glu Ser Gln Pro Leu Asn 
                245                 250                 255     


Thr Phe Met Phe Gln Asn Asn Arg Phe Arg Asn Arg Gln Gly Ala Leu 
            260                 265                 270         


Thr Val Tyr Thr Gly Thr Val Thr Gln Gly Thr Asp Pro Val Lys Thr 
        275                 280                 285             


Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys Ala Met Tyr Asp Ala Tyr 
    290                 295                 300                 


Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe His Ser Gly Phe Asn Glu 
305                 310                 315                 320 


Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln Ser Ser Asp Leu Pro Gln 
                325                 330                 335     


Pro Pro Val Asn Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
        355                 360                 365             


Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Asp Phe Asp Tyr 
    370                 375                 380                 


Glu Lys Met Ala Asn Ala Asn Lys Gly Ala Met Thr Glu Asn Ala Asp 
385                 390                 395                 400 


Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly Lys Leu Asp Ser Val Ala 
                405                 410                 415     


Thr Asp Tyr Gly Ala Ala Asn Gly Asp Ala 
            420                 425     


<210>  34
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding SEQ ID NO 33

<400>  34
atggcgacgc ctgattgtgt aactggaaag gtggagtata caaaatataa tgatgaagat       60

acctttacag ttaaagtggg tgataaagaa ttatttacca acagatggaa tcttcagtct      120

cttcttctca gtgcgcaaat tacggggatg actgtaacca ttaaaactaa tgcctgtcat      180

aatggaggga cattcagcga agttattttt cgtgcggccg cacatcatca tcaccatcac      240

ggggccgcgg aacaaaaact catctcagaa gaggatctga atggggccgc agagcaaaag      300

ctaatatctg aagaagatct caacggggcc gcagaacaga aacttatcag tgaggaggac      360

ttgaatgggg ccgcatagac tgttgaaagt tgtttagcaa aacctcatac agaaaattca      420

tttactaacg tctggaaaga cgacaaaact ctagatcgtt acgctaacta tgagggctgt      480

ctgtggaatg ctacaggcgt tgtggtttgt actggtgacg aaactcagtg ttacggtaca      540

tgggttccta ttgggcttgc tatccctgaa aatgagggtg gtggctctga gggtggcggt      600

tctgagggtg gcggttctga gggtggcggt actaaacctc ctgagtacgg tgatacacct      660

attccgggct atacttatat caaccctctc gacggcactt atccgcctgg tactgagcaa      720

aaccccgcta atcctaatcc ttctcttgag gagtctcagc ctcttaatac tttcatgttt      780

cagaataata ggttccgaaa taggcagggt gcattaactg tttatacggg cactgttact      840

caaggcactg accccgttaa aacttattac cagtacactc ctgtatcatc aaaagccatg      900

tatgacgctt actggaacgg taaattcaga gactgcgctt tccattctgg ctttaatgag      960

gatccattcg tttgtgaata tcaaggccaa tcgtctgacc tgcctcaacc tcctgtcaat     1020

gctggcggcg gctctggtgg tggttctggt ggcggctctg agggtggcgg ctctgagggt     1080

ggcggttctg agggtggcgg ctctgagggt ggcggttccg gtggcggctc cggttccggt     1140

gattttgatt atgaaaaaat ggcaaacgct aataaggggg ctatgaccga aaatgccgat     1200

gaaaacgcgc tacagtctga cgctaaaggc aaacttgatt ctgtcgctac tgattacggt     1260

gctgctaatg gcgacgcc                                                   1278


<210>  35
<211>  4804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pHEN2_STxB phagemid

<400>  35
gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt       60

cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt      120

tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat      180

aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt      240

ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg      300

ctgaagatca gttgggtcca cgagtgggtt acatcgaact ggatctcaac agcggtaaga      360

tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc      420

tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt cgccgcatac      480

actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg      540

gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca      600

acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg      660

gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg      720

acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg      780

gcgaactact tactctagct tcccggcaac aattaataga ctggatggag gcggataaag      840

ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg      900

gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct      960

cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac     1020

agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact     1080

catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga     1140

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     1200

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     1260

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     1320

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc     1380

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     1440

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     1500

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     1560

cgtccacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     1620

agcattgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     1680

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     1740

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     1800

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt     1860

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     1920

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     1980

cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc     2040

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca     2100

acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac tttatgcttc     2160

cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga aacagctatg     2220

accatgatta cgccaagctt gcatgcaaat tctatttcaa ggagacagtc ataatgaaat     2280

acctattgcc tacggcagcc gctggattgt tattactcgc ggcccagccg gccatggcga     2340

cgcctgattg tgtaactgga aaggtggagt atacaaaata taatgatgac gataccttta     2400

cagttaaagt gggtgataaa gaattattta ccaacagatg gaatcttcag tctcttcttc     2460

tcagtgcgca aattacgggg atgactgtaa ccattaaaac taatgcctgt cataatggag     2520

ggggattcag cgaagttatt tttcgtgcgg ccgcacatca tcatcaccat cacggggccg     2580

cggaacaaaa actcatctca gaagaggatc tgaatggggc cgcagagcaa aagctaatat     2640

ctgaagaaga tctcaacggg gccgcagaac agaaacttat cagtgaggag gacttgaatg     2700

gggccgcata gactgttgaa agttgtttag caaaacctca tacagaaaat tcatttacta     2760

acgtctggaa agacgacaaa actctagatc gttacgctaa ctatgagggc tgtctgtgga     2820

atgctacagg cgttgtggtt tgtactggtg acgaaactca gtgttacggt acatgggttc     2880

ctattgggct tgctatccct gaaaatgagg gtggtggctc tgagggtggc ggttctgagg     2940

gtggcggttc tgagggtggc ggtactaaac ctcctgagta cggtgataca cctattccgg     3000

gctatactta tatcaaccct ctcgacggca cttatccgcc tggtactgag caaaaccccg     3060

ctaatcctaa tccttctctt gaggagtctc agcctcttaa tactttcatg tttcagaata     3120

ataggttccg aaataggcag ggtgcattaa ctgtttatac gggcactgtt actcaaggca     3180

ctgaccccgt taaaacttat taccagtaca ctcctgtatc atcaaaagcc atgtatgacg     3240

cttactggaa cggtaaattc agagactgcg ctttccattc tggctttaat gaggatccat     3300

tcgtttgtga atatcaaggc caatcgtctg acctgcctca acctcctgtc aatgctggcg     3360

gcggctctgg tggtggttct ggtggcggct ctgagggtgg cggctctgag ggtggcggtt     3420

ctgagggtgg cggctctgag ggtggcggtt ccggtggcgg ctccggttcc ggtgattttg     3480

attatgaaaa aatggcaaac gctaataagg gggctatgac cgaaaatgcc gatgaaaacg     3540

cgctacagtc tgacgctaaa ggcaaacttg attctgtcgc tactgattac ggtgctgcta     3600

tcgatggttt cattggtgac gtttccggcc ttgctaatgg taatggtgct actggtgatt     3660

ttgctggctc taattcccaa atggctcaag tcggtgacgg tgataattca cctttaatga     3720

ataatttccg tcaatattta ccttctttgc ctcagtcggt tgaatgtcgc ccttatgtct     3780

ttggcgctgg taaaccatat gaattttcta ttgattgtga caaaataaac ttattccgtg     3840

gtgtctttgc gtttctttta tatgttgcca cctttatgta tgtattttcg acgtttgcta     3900

acatactgcg taataaggag tcttaataag aattcactgg ccgtcgtttt acaacgtcgt     3960

gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc     4020

agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg     4080

aatggcgaat ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac     4140

cgcatataaa ttgtaaacgt taatattttg ttaaaattcg cgttaaattt ttgttaaatc     4200

agctcatttt ttaaccaata ggccgaaatc ggcaaaatcc cttataaatc aaaagaatag     4260

cccgagatag ggttgagtgt tgttccagtt tggaacaaga gtccactatt aaagaacgtg     4320

gactccaacg tcaaagggcg aaaaaccgtc tatcagggcg atggcccact acgtgaacca     4380

tcacccaaat caagtttttt ggggtcgagg tgccgtaaag cactaaatcg gaaccctaaa     4440

gggagccccc gatttagagc ttgacgggga aagccggcga acgtggcgag aaaggaaggg     4500

aagaaagcga aaggagcggg cgctagggcg ctggcaagtg tagcggtcac gctgcgcgta     4560

accaccacac ccgccgcgct taatgcgccg ctacagggcg cgtactatgg ttgctttgac     4620

gggtccactc tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg     4680

ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa     4740

gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc     4800

gcga                                                                  4804


<210>  36
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO 1 with the first amino-acid residue being A

<400>  36

Ala Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  37
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected among T, A or S

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is selected among D, E or N

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is selected among T, A or S

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is selected among L, I or V

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is selected among F, Y, W or A

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is selected among N, E or S

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa is selected among R, K or E

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa is selected among T, A or S

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa is selected among T, A or S

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Xaa is selected among G, A, S or T

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  Xaa is selected among F, L or Y

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Xaa is selected among T, A or S

<400>  37

Xaa Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Xaa 
1               5                   10                  15      


Asp Asp Thr Phe Xaa Val Lys Val Gly Asp Lys Glu Xaa Xaa Thr Xaa 
            20                  25                  30          


Xaa Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Xaa Asn Xaa Cys His Asn Gly Gly Xaa Xaa Xaa 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1

<400>  38

Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn 
1               5                   10                  


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S3

<400>  39

Val Lys Val Gly Asp Lys 
1               5       


<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S4

<400>  40

Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met Thr Val Thr 
1               5                   10                  15      


Ile Lys 
        


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S7

<400>  41

Glu Val Ile Phe Arg 
1               5   


<210>  42
<211>  424
<212>  PRT
<213>  Unknown

<220>
<223>  wild-type pIII protein having 424 amino-acids residues

<400>  42

Met Lys Lys Leu Leu Phe Ala Ile Pro Leu Val Val Pro Phe Tyr Ser 
1               5                   10                  15      


His Ser Ala Glu Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu 
            20                  25                  30          


Asn Ser Phe Thr Asn Val Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr 
        35                  40                  45              


Ala Asn Tyr Glu Gly Cys Leu Trp Asn Ala Thr Gly Val Val Val Cys 
    50                  55                  60                  


Thr Gly Asp Glu Thr Gln Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu 
65                  70                  75                  80  


Ala Ile Pro Glu Asn Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu 
                85                  90                  95      


Gly Gly Gly Ser Glu Gly Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp 
            100                 105                 110         


Thr Pro Ile Pro Gly Tyr Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr 
        115                 120                 125             


Pro Pro Gly Thr Glu Gln Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu 
    130                 135                 140                 


Glu Ser Gln Pro Leu Asn Thr Phe Met Phe Gln Asn Asn Arg Phe Arg 
145                 150                 155                 160 


Asn Arg Gln Gly Ala Leu Thr Val Tyr Thr Gly Thr Val Thr Gln Gly 
                165                 170                 175     


Thr Asp Pro Val Lys Thr Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys 
            180                 185                 190         


Ala Met Tyr Asp Ala Tyr Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe 
        195                 200                 205             


His Ser Gly Phe Asn Glu Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln 
    210                 215                 220                 


Ser Ser Asp Leu Pro Gln Pro Pro Val Asn Ala Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly 
                245                 250                 255     


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            260                 265                 270         


Ser Gly Asp Phe Asp Tyr Glu Lys Met Ala Asn Ala Asn Lys Gly Ala 
        275                 280                 285             


Met Thr Glu Asn Ala Asp Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly 
    290                 295                 300                 


Lys Leu Asp Ser Val Ala Thr Asp Tyr Gly Ala Ala Ile Asp Gly Phe 
305                 310                 315                 320 


Ile Gly Asp Val Ser Gly Leu Ala Asn Gly Asn Gly Ala Thr Gly Asp 
                325                 330                 335     


Phe Ala Gly Ser Asn Ser Gln Met Ala Gln Val Gly Asp Gly Asp Asn 
            340                 345                 350         


Ser Pro Leu Met Asn Asn Phe Arg Gln Tyr Leu Pro Ser Leu Pro Gln 
        355                 360                 365             


Ser Val Glu Cys Arg Pro Phe Val Phe Ser Ala Gly Lys Pro Tyr Glu 
    370                 375                 380                 


Phe Ser Ile Asp Cys Asp Lys Ile Asn Leu Phe Arg Gly Val Phe Ala 
385                 390                 395                 400 


Phe Leu Leu Tyr Val Ala Thr Phe Met Tyr Val Phe Ser Thr Phe Ala 
                405                 410                 415     


Asn Ile Leu Arg Asn Lys Glu Ser 
            420                 


<210>  43
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D16N mutant

<400>  43

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asn 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  44
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D17N mutant

<400>  44

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asn Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  45
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D17E mutant

<400>  45

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Glu Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  46
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D16N D17N mutant

<400>  46

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asn 
1               5                   10                  15      


Asn Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  47
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D18N mutant

<400>  47

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asp Asn Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  48
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F30A mutant

<400>  48

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Ala Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  49
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R33D mutant

<400>  49

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Asp Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  50
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  W34G mutant

<400>  50

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Gly Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  51
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  W34A mutant

<400>  51

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Ala Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Gly Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  52
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G62T mutant

<400>  52

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Asp Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Thr Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


<210>  53
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D17E G62T mutant

<400>  53

Thr Pro Asp Cys Val Thr Gly Lys Val Glu Tyr Thr Lys Tyr Asn Asp 
1               5                   10                  15      


Glu Asp Thr Phe Thr Val Lys Val Gly Asp Lys Glu Leu Phe Thr Asn 
            20                  25                  30          


Arg Trp Asn Leu Gln Ser Leu Leu Leu Ser Ala Gln Ile Thr Gly Met 
        35                  40                  45              


Thr Val Thr Ile Lys Thr Asn Ala Cys His Asn Gly Gly Thr Phe Ser 
    50                  55                  60                  


Glu Val Ile Phe Arg 
65                  


