                         SEQUENCE LISTING

<110>  Implicit Bioscience Pty Ltd
 
<120>  AGENTS FOR TREATING DISEASE AND USES THEREFOR

<130>  35283585/VPA/TKU

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised VL domain

<400>  1

Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
1               5                   10                  15      


Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser Phe Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Ser Ser Ile Tyr 
        35                  40                  45              


Arg Ala Ala Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Glu Asp Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Gly Asn Gln 
            100                 105     


<210>  2
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised VH domain

<400>  2

Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly 
1               5                   10                  15      


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu 
            20                  25                  30          


Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Ser Gly Gly Thr Thr Tyr 
        35                  40                  45              


Tyr Pro Asp Asn Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    50                  55                  60                  


Arg Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
65                  70                  75                  80  


Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Tyr Asp Tyr His Tyr Trp Gly 
                85                  90                  95      


Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105 


<210>  3
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised VL domain

<400>  3

Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
1               5                   10                  15      


Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Val Asn Ser Phe Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Arg Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asp 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Cys Cys Gln Gln Ser Asn Glu Asp Pro Thr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  4
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised VH domain

<400>  4

Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser Leu Ser 
1               5                   10                  15      


Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Ser Ala Trp 
            20                  25                  30          


Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu Glu Trp Met Gly Tyr 
        35                  40                  45              


Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys Ser Arg 
    50                  55                  60                  


Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Gln Leu 
65                  70                  75                  80  


Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Val Arg Gly 
                85                  90                  95      


Leu Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


<210>  5
<211>  101
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised VL domain

<400>  5

Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile 
1               5                   10                  15      


Ser Cys Arg Ala Ser Gln Asp Ile Lys Asn Tyr Leu Asn Trp Tyr Gln 
            20                  25                  30          


Gln Pro Gly Gly Thr Val Lys Val Leu Ile Tyr Tyr Thr Ser Arg Leu 
        35                  40                  45              


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    50                  55                  60                  


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Phe Ala Thr Tyr 
65                  70                  75                  80  


Phe Cys Gln Arg Gly Asp Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Leu Glu Ile Lys 
            100     


<210>  6
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised VH domain

<400>  6

Leu Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile 
1               5                   10                  15      


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Asp Ile Ser Trp 
            20                  25                  30          


Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
        35                  40                  45              


Thr Ser Gly Gly Thr Asn Tyr Asn Ser Ala Phe Met Ser Arg Leu Ser 
    50                  55                  60                  


Ile Thr Lys Asp Asn Ser Glu Ser Gln Val Phe Leu Lys Met Asn Gly 
65                  70                  75                  80  


Leu Gln Thr Asp Asp Thr Gly Ile Tyr Tyr Cys Val Arg Gly Asp Gly 
                85                  90                  95      


Asn Phe Tyr Leu Tyr Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  7
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised CDR1

<400>  7

Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  8
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised L-CDR2

<400>  8

Arg Ala Ala Asn Leu Glu Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised L-CDR3

<400>  9

Gln Gln Ser Tyr Glu Asp Pro Trp Thr 
1               5                   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised H-CDR1

<400>  10

Ser Tyr Ala Met Ser 
1               5   


<210>  11
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised H-CDR2

<400>  11

Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Asn Val Lys Gly 
1               5                   10                  15      


<210>  12
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised H-CDR3

<400>  12

Gly Tyr Tyr Asp Tyr His Tyr 
1               5           


<210>  13
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised L-CDR1

<400>  13

Arg Ala Ser Glu Ser Val Asp Ser Tyr Val Asn Ser Phe Leu His 
1               5                   10                  15  


<210>  14
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised L-CDR2

<400>  14

Arg Ala Ser Asn Leu Gln Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised L-CDR3

<400>  15

Gln Gln Ser Asn Glu Asp Pro Thr Thr 
1               5                   


<210>  16
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised H-CDR1

<400>  16

Ser Asp Ser Ala Trp Asn 
1               5       


<210>  17
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised H-CDR2

<400>  17

Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  18
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised H-CDR3

<400>  18

Gly Leu Arg Phe Ala Tyr 
1               5       


<210>  19
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised L-CDR1

<400>  19

Arg Ala Ser Gln Asp Ile Lys Asn Tyr Leu Asn 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised L-CDR2

<400>  20

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised L-CDR3

<400>  21

Gln Arg Gly Asp Thr Leu Pro Trp Thr 
1               5                   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised H-CDR1

<400>  22

Asn Tyr Asp Ile Ser 
1               5   


<210>  23
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised H-CDR2

<400>  23

Val Ile Trp Thr Ser Gly Gly Thr Asn Tyr Asn Ser Ala Phe Met Ser 
1               5                   10                  15      


<210>  24
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised H-CDR3

<400>  24

Gly Asp Gly Asn Phe Tyr Leu Tyr Asn Phe Asp Tyr 
1               5                   10          


<210>  25
<211>  238
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised VL domain

<400>  25

Met Glu Thr Asp Thr Ile Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Ser Tyr Val Asn Ser Phe Leu His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Gln Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Ser Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  26
<211>  460
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanised VH domain

<400>  26

Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Asp Ser Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Val Arg Gly Leu Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
225                 230                 235                 240 


Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460 




Document11-20/04/2018




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