                         SEQUENCE LISTING

<110>  Xiao, Shouhua
       Zhu, Xiaodong
 
<120>  Biparatopic and Multiparatopic Antibodies with Common Light Chain
        and Method of Use

<130>  1403346-00002

<150>  US 62/483,456
<151>  2017-04-09

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pertuzumab light chain variable region

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  2
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pertuzumab light chain

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pertuzumab heavy chain variable region

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  4
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pertuzumab heavy chain

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  5
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trastuzumab light chain variable region

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  6
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trastuzumab light chain

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trastuzumab heavy chain variable region

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trastuzumab heavy chain

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  9
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asp Asn Trp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ala Lys Ala Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  10
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asp Asn Trp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ala Lys Ala Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Gly Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  11
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Thr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  12
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Thr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  13
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biparatopic antibody construct HC11

<400>  13

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ala Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
        275                 280                 285             


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    290                 295                 300                 


Trp Val Ala Arg Ile Tyr Pro Thr Thr Gly Tyr Thr Arg Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ser Arg Trp Gly Gly Ser Gly Phe Tyr Ala Met Asp Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
385                 390                 395                 400 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    450                 455                 460                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
465                 470                 475                 480 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                485                 490                 495     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            500                 505                 510         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        515                 520                 525             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    530                 535                 540                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
545                 550                 555                 560 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                565                 570                 575     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            580                 585                 590         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        595                 600                 605             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    610                 615                 620                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
625                 630                 635                 640 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                645                 650                 655     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            660                 665                 670         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        675                 680                 685             


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    690                 695                 700                 


Ser Pro Gly Lys 
705             


<210>  14
<211>  2146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Biparatopic antibody construct HC11

<400>  14
gaattcgcca ccatgaactt tggcctgagc ctgatttttc tcgtcctgat cctgaagggc       60

gtgcagtgtg aggtgcagct ggtggagagc ggcggcggcc tggtgcagcc cggcggcagc      120

ctgcgcctgt cctgcgccgc cagcggcttc acctttgccg actacaccat ggactgggtg      180

cgccaggctc ccggcaaggg cctggagtgg gtggccgacg tgaaccccaa cagcggcggc      240

agcatctaca accagcgctt caagggccgc ttcaccctga gcgtggaccg cagcaagaac      300

accctgtacc tgcagatgaa cagcctgcgc gccgaggaca ccgccgtgta ctactgcgcc      360

cgcaacctgg gccccagctt ctacttcgac tattgggggc agggcaccct ggtcaccgtg      420

agcagcgcta gcaccaaggg cccatccgtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagctgccct gggctgcctg gtcaaggact acttccccga accagtgacc      540

gtgtcctgga actcaggcgc cctgaccagc ggcgtgcaca ccttccctgc tgtcctgcag      600

tcctcaggac tctactccct cagcagcgtg gtgactgtgc cctctagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgacaa aggcggaggg agcggcggag gctccggagg cggcagcgga      780

ggcggagagg tgcagctggt ggagtctgga ggagggctgg tgcagccagg agggtccctg      840

agactgtctt gcgccgctag tggcttcaac atcaaggaca cctacatcca ctgggtgaga      900

caggcccccg gaaaaggcct ggagtgggtg gccaggatct accctaccac cggctacacc      960

aggtacgccg acagcgtgaa gggcaggttc accatcagcg ccgacaccag caagaacacc     1020

gcctacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcagcaga     1080

tggggcggca gcggcttcta cgccatggac tactggggac agggcacact ggtcactgtg     1140

tctagtgcct caacaaaggg gcctagcgtg tttccactgg ctccctcaag caaaagcact     1200

tccggaggca ccgctgcact gggatgtctg gtgaaggact acttcccaga gcccgtcacc     1260

gtgtcttgga acagtggggc tctgaccagc ggagtccaca catttcctgc agtgctgcag     1320

tcctctggcc tgtacagcct gagttcagtg gtcacagtcc caagctcctc tctggggacc     1380

cagacatata tctgcaacgt gaatcacaag ccaagcaata ctaaagtcga caagaaagtg     1440

gagcccaaga gctgtgataa aactcatacc tgcccccctt gtcctgcacc agaactgctg     1500

ggaggaccat ccgtgttcct gtttccaccc aagcctaaag acaccctgat gatttcccgc     1560

acacccgagg tcacttgcgt ggtcgtggac gtgtctcacg aggaccccga agtcaagttc     1620

aactggtacg tggatggcgt cgaagtgcat aatgctaaga ccaaaccaag ggaggaacag     1680

tacaactcca catatcgcgt cgtgtctgtc ctgactgtgc tgcaccagga ttggctgaac     1740

ggcaaagagt ataagtgcaa agtgagcaat aaggccctgc ccgctcctat cgagaaaact     1800

attagcaagg ctaaagggca gcctcgcgaa ccacaggtgt acaccctgcc tccatctcgg     1860

gacgaactga ctaagaacca agtcagtctg acctgtctgg tgaaagggtt ctatcctagc     1920

gacattgcag tggagtggga atccaatgga cagccagaga acaattacaa gaccacaccc     1980

cctgtgctgg actcagatgg aagcttcttt ctgtatagta agctgaccgt ggataaatca     2040

cgctggcagc agggcaacgt cttttcttgt agtgtgctgc atgaagccct gcacaatcat     2100

tacacacaga agtcactgag cctgtcccct ggcaaatgaa ggatcc                    2146


<210>  15
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biparatopic antibody construct HC12

<400>  15

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ala Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Ala Ser Ile Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
        275                 280                 285             


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    290                 295                 300                 


Trp Val Ala Arg Ile Tyr Pro Thr Thr Gly Tyr Thr Arg Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ser Arg Trp Gly Gly Ser Gly Phe Tyr Ala Met Asp Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
385                 390                 395                 400 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    450                 455                 460                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
465                 470                 475                 480 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                485                 490                 495     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            500                 505                 510         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        515                 520                 525             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    530                 535                 540                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
545                 550                 555                 560 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                565                 570                 575     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            580                 585                 590         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        595                 600                 605             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    610                 615                 620                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
625                 630                 635                 640 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                645                 650                 655     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            660                 665                 670         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        675                 680                 685             


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    690                 695                 700                 


Ser Pro Gly Lys 
705             


<210>  16
<211>  2146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Biparatopic antibody construct HC12

<400>  16
gaattcgcca ccatgaactt tggcctgagc ctgatttttc tcgtcctgat cctgaagggc       60

gtgcagtgtg aggtgcagct ggtggagagc ggcggcggcc tggtgcagcc cggcggcagc      120

ctgcgcctgt cctgcgccgc cagcggcttc acctttgccg actacaccat ggactgggtg      180

cgccaggctc ccggcaaggg cctggagtgg gtggccgacg tgaaccccaa cagcggcgcc      240

agcatctaca accagcgctt caagggccgc ttcaccctga gcgtggaccg cagcaagaac      300

accctgtacc tgcagatgaa cagcctgcgc gccgaggaca ccgccgtgta ctactgcgcc      360

cgcaacctgg gccccagctt ctacttcgac tattgggggc agggcaccct ggtcaccgtg      420

agcagcgcta gcaccaaggg cccatccgtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagctgccct gggctgcctg gtcaaggact acttccccga accagtgacc      540

gtgtcctgga actcaggcgc cctgaccagc ggcgtgcaca ccttccctgc tgtcctgcag      600

tcctcaggac tctactccct cagcagcgtg gtgactgtgc cctctagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgacaa aggcggaggg agcggcggag gctccggagg cggcagcgga      780

ggcggagagg tgcagctggt ggagtctgga ggagggctgg tgcagccagg agggtccctg      840

agactgtctt gcgccgctag tggcttcaac atcaaggaca cctacatcca ctgggtgaga      900

caggcccccg gaaaaggcct ggagtgggtg gccaggatct accctaccac cggctacacc      960

aggtacgccg acagcgtgaa gggcaggttc accatcagcg ccgacaccag caagaacacc     1020

gcctacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcagcaga     1080

tggggcggca gcggcttcta cgccatggac tactggggac agggcacact ggtcactgtg     1140

tctagtgcct caacaaaggg gcctagcgtg tttccactgg ctccctcaag caaaagcact     1200

tccggaggca ccgctgcact gggatgtctg gtgaaggact acttcccaga gcccgtcacc     1260

gtgtcttgga acagtggggc tctgaccagc ggagtccaca catttcctgc agtgctgcag     1320

tcctctggcc tgtacagcct gagttcagtg gtcacagtcc caagctcctc tctggggacc     1380

cagacatata tctgcaacgt gaatcacaag ccaagcaata ctaaagtcga caagaaagtg     1440

gagcccaaga gctgtgataa aactcatacc tgcccccctt gtcctgcacc agaactgctg     1500

ggaggaccat ccgtgttcct gtttccaccc aagcctaaag acaccctgat gatttcccgc     1560

acacccgagg tcacttgcgt ggtcgtggac gtgtctcacg aggaccccga agtcaagttc     1620

aactggtacg tggatggcgt cgaagtgcat aatgctaaga ccaaaccaag ggaggaacag     1680

tacaactcca catatcgcgt cgtgtctgtc ctgactgtgc tgcaccagga ttggctgaac     1740

ggcaaagagt ataagtgcaa agtgagcaat aaggccctgc ccgctcctat cgagaaaact     1800

attagcaagg ctaaagggca gcctcgcgaa ccacaggtgt acaccctgcc tccatctcgg     1860

gacgaactga ctaagaacca agtcagtctg acctgtctgg tgaaagggtt ctatcctagc     1920

gacattgcag tggagtggga atccaatgga cagccagaga acaattacaa gaccacaccc     1980

cctgtgctgg actcagatgg aagcttcttt ctgtatagta agctgaccgt ggataaatca     2040

cgctggcagc agggcaacgt cttttcttgt agtgtgctgc atgaagccct gcacaatcat     2100

tacacacaga agtcactgag cctgtcccct ggcaaatgaa ggatcc                    2146


<210>  17
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biparatopic antibody construct HC13

<400>  17

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ala Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                485                 490                 495     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
            500                 505                 510         


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        515                 520                 525             


Trp Val Ala Arg Ile Tyr Pro Thr Thr Gly Tyr Thr Arg Tyr Ala Asp 
    530                 535                 540                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
545                 550                 555                 560 


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                565                 570                 575     


Tyr Cys Ser Arg Trp Gly Gly Ser Gly Phe Tyr Ala Met Asp Tyr Trp 
            580                 585                 590         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        595                 600                 605             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    610                 615                 620                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
625                 630                 635                 640 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                645                 650                 655     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            660                 665                 670         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        675                 680                 685             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    690                 695                 700                 


Cys 
705 


<210>  18
<211>  2137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Biparatopic antibody construct HC13

<400>  18
gaattcgcca ccatgaactt tggcctgagc ctgatttttc tcgtcctgat cctgaagggc       60

gtgcagtgtg aggtgcagct ggtggagagc ggcggcggcc tggtgcagcc cggcggcagc      120

ctgcgcctgt cctgcgccgc cagcggcttc acctttgccg actacaccat ggactgggtg      180

cgccaggctc ccggcaaggg cctggagtgg gtggccgacg tgaaccccaa cagcggcggc      240

agcatctaca accagcgctt caagggccgc ttcaccctga gcgtggaccg cagcaagaac      300

accctgtacc tgcagatgaa cagcctgcgc gccgaggaca ccgccgtgta ctactgcgcc      360

cgcaacctgg gccccagctt ctacttcgac tattgggggc agggcaccct ggtcaccgtg      420

agcagcgcta gcaccaaggg cccatccgtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagctgccct gggctgcctg gtcaaggact acttccccga accagtgacc      540

gtgtcctgga actcaggcgc cctgaccagc ggcgtgcaca ccttccctgc tgtcctgcag      600

tcctcaggac tctactccct cagcagcgtg gtgactgtgc cctctagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgataa aactcatacc tgcccccctt gtcctgcacc agaactgctg      780

ggaggaccat ccgtgttcct gtttccaccc aagcctaaag acaccctgat gatttcccgc      840

acacccgagg tcacttgcgt ggtcgtggac gtgtctcacg aggaccccga agtcaagttc      900

aactggtacg tggatggcgt cgaagtgcat aatgctaaga ccaaaccaag ggaggaacag      960

tacaactcca catatcgcgt cgtgtctgtc ctgactgtgc tgcaccagga ttggctgaac     1020

ggcaaagagt ataagtgcaa agtgagcaat aaggccctgc ccgctcctat cgagaaaact     1080

attagcaagg ctaaagggca gcctcgcgaa ccacaggtgt acaccctgcc tccatctcgg     1140

gacgaactga ctaagaacca agtcagtctg acctgtctgg tgaaagggtt ctatcctagc     1200

gacattgcag tggagtggga atccaatgga cagccagaga acaattacaa gaccacaccc     1260

cctgtgctgg actcagatgg aagcttcttt ctgtatagta agctgaccgt ggataaatca     1320

cgctggcagc agggcaacgt cttttcttgt agtgtgctgc atgaagccct gcacaatcat     1380

tacacacaga agtcactgag cctgtcccct ggcggcggag ggagcggcgg aggctccgga     1440

ggcggcagcg gaggcggaga ggtgcagctg gtggagtctg gaggagggct ggtgcagcca     1500

ggagggtccc tgagactgtc ttgcgccgct agtggcttca acatcaagga cacctacatc     1560

cactgggtga gacaggcccc cggaaaaggc ctggagtggg tggccaggat ctaccctacc     1620

accggctaca ccaggtacgc cgacagcgtg aagggcaggt tcaccatcag cgccgacacc     1680

agcaagaaca ccgcctacct gcagatgaac agcctgaggg ccgaggacac cgccgtgtac     1740

tactgcagca gatggggcgg cagcggcttc tacgccatgg actactgggg acagggcaca     1800

ctggtcactg tgtctagtgc ctcaacaaag gggcctagcg tgtttccact ggctccctca     1860

agcaaaagca cttccggagg caccgctgca ctgggatgtc tggtgaagga ctacttccca     1920

gagcccgtca ccgtgtcttg gaacagtggg gctctgacca gcggagtcca cacatttcct     1980

gcagtgctgc agtcctctgg cctgtacagc ctgagttcag tggtcacagt cccaagctcc     2040

tctctgggga cccagacata tatctgcaac gtgaatcaca agccaagcaa tactaaagtc     2100

gacaagaaag tggagcccaa gagctgttga aggatcc                              2137


<210>  19
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biparatopic antibody construct HC14

<400>  19

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ala Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  20
<211>  1426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Biparatopic antibody construct HC14

<400>  20
gaattcgcca ccatgaactt tggcctgagc ctgatttttc tcgtcctgat cctgaagggc       60

gtgcagtgtg aggtgcagct ggtggagagc ggcggcggcc tggtgcagcc cggcggcagc      120

ctgcgcctgt cctgcgccgc cagcggcttc acctttgccg actacaccat ggactgggtg      180

cgccaggctc ccggcaaggg cctggagtgg gtggccgacg tgaaccccaa cagcggcggc      240

agcatctaca accagcgctt caagggccgc ttcaccctga gcgtggaccg cagcaagaac      300

accctgtacc tgcagatgaa cagcctgcgc gccgaggaca ccgccgtgta ctactgcgcc      360

cgcaacctgg gccccagctt ctacttcgac tattgggggc agggcaccct ggtcaccgtg      420

agcagcgcta gcaccaaggg cccatccgtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagctgccct gggctgcctg gtcaaggact acttccccga accagtgacc      540

gtgtcctgga actcaggcgc cctgaccagc ggcgtgcaca ccttccctgc tgtcctgcag      600

tcctcaggac tctactccct cagcagcgtg gtgactgtgc cctctagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgataa aactcatacc tgcccccctt gtcctgcacc agaactgctg      780

ggaggaccat ccgtgttcct gtttccaccc aagcctaaag acaccctgat gatttcccgc      840

acacccgagg tcacttgcgt ggtcgtggac gtgtctcacg aggaccccga agtcaagttc      900

aactggtacg tggatggcgt cgaagtgcat aatgctaaga ccaaaccaag ggaggaacag      960

tacaactcca catatcgcgt cgtgtctgtc ctgactgtgc tgcaccagga ttggctgaac     1020

ggcaaagagt ataagtgcaa agtgagcaat aaggccctgc ccgctcctat cgagaaaact     1080

attagcaagg ctaaagggca gcctcgcgaa ccacaggtgt acaccctgcc tccatctcgg     1140

gacgaactga ctaagaacca agtcagtctg tggtgtctgg tgaaagggtt ctatcctagc     1200

gacattgcag tggagtggga atccaatgga cagccagaga acaattacaa gaccacaccc     1260

cctgtgctgg actcagatgg aagcttcttt ctgtatagta agctgaccgt ggataaatca     1320

cgctggcagc agggcaacgt cttttcttgt agtgtgctgc atgaagccct gcacaatcat     1380

tacacacaga agtcactgag cctgtcccct ggcaaatgaa ggatcc                    1426


<210>  21
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Biparatopic antibody construct HC15

<400>  21

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Tyr Pro Thr Thr Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Trp Gly Gly Ser Gly Phe Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  22
<211>  1429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Biparatopic antibody construct HC15

<400>  22
gaattcgcca ccatgaactt tggcctgagc ctgatttttc tcgtcctgat cctgaagggc       60

gtgcagtgtg aggtgcagct ggtggagtct ggaggagggc tggtgcagcc aggagggtcc      120

ctgagactgt cttgcgccgc tagtggcttc aacatcaagg acacctacat ccactgggtg      180

agacaggccc ccggaaaagg cctggagtgg gtggccagga tctaccctac caccggctac      240

accaggtacg ccgacagcgt gaagggcagg ttcaccatca gcgccgacac cagcaagaac      300

accgcctacc tgcagatgaa cagcctgagg gccgaggaca ccgccgtgta ctactgcagc      360

agatggggcg gcagcggctt ctacgccatg gactactggg gacagggcac actggtcact      420

gtgtctagtg cctcaacaaa ggggcctagc gtgtttccac tggctccctc aagcaaaagc      480

acttccggag gcaccgctgc actgggatgt ctggtgaagg actacttccc agagcccgtc      540

accgtgtctt ggaacagtgg ggctctgacc agcggagtcc acacatttcc tgcagtgctg      600

cagtcctctg gcctgtacag cctgagttca gtggtcacag tcccaagctc ctctctgggg      660

acccagacat atatctgcaa cgtgaatcac aagccaagca atactaaagt cgacaagaaa      720

gtggagccca agagctgtga taaaactcat acctgccccc cttgtcctgc accagaactg      780

ctgggaggac catccgtgtt cctgtttcca cccaagccta aagacaccct gatgatttcc      840

cgcacacccg aggtcacttg cgtggtcgtg gacgtgtctc acgaggaccc cgaagtcaag      900

ttcaactggt acgtggatgg cgtcgaagtg cataatgcta agaccaaacc aagggaggaa      960

cagtacaact ccacatatcg cgtcgtgtct gtcctgactg tgctgcacca ggattggctg     1020

aacggcaaag agtataagtg caaagtgagc aataaggccc tgcccgctcc tatcgagaaa     1080

actattagca aggctaaagg gcagcctcgc gaaccacagg tgtacaccct gcctccatct     1140

cgggacgaac tgactaagaa ccaagtcagt ctgagctgtg ccgtgaaagg gttctatcct     1200

agcgacattg cagtggagtg ggaatccaat ggacagccag agaacaatta caagaccaca     1260

ccccctgtgc tggactcaga tggaagcttc tttctggtga gtaagctgac cgtggataaa     1320

tcacgctggc agcagggcaa cgtcttttct tgtagtgtgc tgcatgaagc cctgcacaat     1380

cattacacac agaagtcact gagcctgtcc cctggcaaat gaaggatcc                 1429


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  23

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15  


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence

<400>  24

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  25
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence

<400>  25

Gly Gly Cys Gly Gly Ala Gly Gly Gly Ala Gly Cys Gly Gly Cys Gly 
1               5                   10                  15      


Gly Ala Gly Gly Cys Thr Cys Cys Gly Gly Ala Gly Gly Cys Gly Gly 
            20                  25                  30          


Cys Ala Gly Cys Gly Gly Ala Gly Gly Cys Gly Gly Ala 
        35                  40                  45  


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EcoRI/Kozak sequence

<400>  26

Gly Ala Ala Thr Thr Cys Gly Cys Cys Ala Cys Cys 
1               5                   10          


<210>  27
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BamHI cloning site

<400>  27
aggatcc                                                                  7


<210>  28
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal sequence

<400>  28
atgaactttg gcctgagcct gatttttctc gtcctgatcc tgaagggcgt gcagtgt          57


<210>  29
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pert_VH_V16xCH1FcML

<400>  29

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys 
            


<210>  30
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tra_VH-VNT_DSCH1

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Thr Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Ser Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  31
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pert_VH_V16xCH1FcML-linker-Tra_VH-VNT_DSCH1

<400>  31

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
        275                 280                 285             


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    290                 295                 300                 


Trp Val Ala Arg Ile Tyr Pro Thr Thr Gly Tyr Thr Arg Tyr Ala Asp 
305                 310                 315                 320 


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
                325                 330                 335     


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            340                 345                 350         


Tyr Cys Ser Arg Trp Gly Gly Ser Gly Phe Tyr Ala Met Asp Tyr Trp 
        355                 360                 365             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
385                 390                 395                 400 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    450                 455                 460                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
465                 470                 475                 480 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                485                 490                 495     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            500                 505                 510         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        515                 520                 525             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    530                 535                 540                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
545                 550                 555                 560 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                565                 570                 575     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            580                 585                 590         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        595                 600                 605             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    610                 615                 620                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
625                 630                 635                 640 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                645                 650                 655     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            660                 665                 670         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        675                 680                 685             


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    690                 695                 700                 


Ser Pro Gly Lys 
705             


<210>  32
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pert_Fab+Fc

<400>  32

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly 
465         


<210>  33
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tras_Fab

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Thr Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Ser Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  34
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pert_HC_v2x-Tra_HC_vNT_DS_ML

<400>  34

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                485                 490                 495     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
            500                 505                 510         


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        515                 520                 525             


Trp Val Ala Arg Ile Tyr Pro Thr Thr Gly Tyr Thr Arg Tyr Ala Asp 
    530                 535                 540                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
545                 550                 555                 560 


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                565                 570                 575     


Tyr Cys Ser Arg Trp Gly Gly Ser Gly Phe Tyr Ala Met Asp Tyr Trp 
            580                 585                 590         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        595                 600                 605             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    610                 615                 620                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
625                 630                 635                 640 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                645                 650                 655     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            660                 665                 670         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        675                 680                 685             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    690                 695                 700                 


Cys 
705 


<210>  35
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pert_HC_v16x Knob

<400>  35

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn 
65                  70                  75                  80  


Gln Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Leu His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  36
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tras_HC_hole

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Thr Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Ser Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  37
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gTra_HC_vNT_DT_ML

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Thr Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Thr Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  38
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EcoRI-Kozak-Pert_VH_V16xCH1FcML

<400>  38
gaattcgcca ccatgaactt tggcctgagc ctgatttttc tcgtcctgat cctgaagggc       60

gtgcagtgtg aggtgcagct ggtggagagc ggcggcggcc tggtgcagcc cggcggcagc      120

ctgcgcctgt cctgcgccgc cagcggcttc acctttaccg actacaccat ggactgggtg      180

cgccaggctc ccggcaaggg cctggagtgg gtggccgacg tgaaccccaa cagcggcggc      240

agcatctaca accagcgctt caagggccgc ttcaccctga gcgtggaccg cagcaagaac      300

accctgtacc tgcagatgaa cagcctgcgc gccgaggaca ccgccgtgta ctactgcgcc      360

cgcaacctgg gccccagctt ctacttcgac tattgggggc agggcaccct ggtcaccgtg      420

agcagcgcta gcaccaaggg cccatccgtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagctgccct gggctgcctg gtcaaggact acttccccga accagtgacc      540

gtgtcctgga actcaggcgc cctgaccagc ggcgtgcaca ccttccctgc tgtcctgcag      600

tcctcaggac tctactccct cagcagcgtg gtgactgtgc cctctagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgacaa a                                                741


<210>  39
<211>  1360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tra_VH-VNT_DSCH1

<400>  39
gaggtgcagc tggtggagtc tggaggaggg ctggtgcagc caggagggtc cctgagactg       60

tcttgcgccg ctagtggctt caacatcaag gacacctaca tccactgggt gagacaggcc      120

cccggaaaag gcctggagtg ggtggccagg atctacccta ccaccggcta caccaggtac      180

gccgacagcg tgaagggcag gttcaccatc agcgccgaca ccagcaagaa caccgcctac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcag cagatggggc      300

ggcagcggct tctacgccat ggactactgg ggacagggca cactggtcac tgtgtctagt      360

gcctcaacaa aggggcctag cgtgtttcca ctggctccct caagcaaaag cacttccgga      420

ggcaccgctg cactgggatg tctggtgaag gactacttcc cagagcccgt caccgtgtct      480

tggaacagtg gggctctgac cagcggagtc cacacatttc ctgcagtgct gcagtcctct      540

ggcctgtaca gcctgagttc agtggtcaca gtcccaagct cctctctggg gacccagaca      600

tatatctgca acgtgaatca caagccaagc aatactaaag tcgacaagaa agtggagccc      660

aagagctgtg ataaaactca tacctgcccc ccttgtcctg caccagaact gctgggagga      720

ccatccgtgt tcctgtttcc acccaagcct aaagacaccc tgatgatttc ccgcacaccc      780

gaggtcactt gcgtggtcgt ggacgtgtct cacgaggacc ccgaagtcaa gttcaactgg      840

tacgtggatg gcgtcgaagt gcataatgct aagaccaaac caagggagga acagtacaac      900

tccacatatc gcgtcgtgtc tgtcctgact gtgctgcacc aggattggct gaacggcaaa      960

gagtataagt gcaaagtgag caataaggcc ctgcccgctc ctatcgagaa aactattagc     1020

aaggctaaag ggcagcctcg cgaaccacag gtgtacaccc tgcctccatc tcgggaggaa     1080

atgactaaga accaagtcag tctgacctgt ctggtgaaag ggttctatcc tagcgacatt     1140

gcagtggagt gggaatccaa tggacagcca gagaacaatt acaagaccac accccctgtg     1200

ctggactcag atggaagctt ctttctgtat agtaagctga ccgtggataa atcacgctgg     1260

cagcagggca acgtcttttc ttgtagtgtg ctgcatgaag ccctgcacaa tcattacaca     1320

cagaagtcac tgagcctgtc ccctggcaaa tgaaggatcc                           1360


<210>  40
<211>  2127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pert_HC_v2x_Tra_HC_vNT_DS_ML

<400>  40
gaattcgcca ccatgaactt tggcctgagc ctgatttttc tcgtcctgat cctgaagggc       60

gtgcagtgtg aggtgcagct ggtggagagc ggcggcggcc tggtgcagcc cggcggcagc      120

ctgcgcctgt cctgcgccgc cagcggcttc acctttaccg actacaccat ggactgggtg      180

cgccaggctc ccggcaaggg cctggagtgg gtggccgacg tgaaccccaa cagcggcggc      240

agcatctaca accagcgctt caagggccgc ttcaccctga gcgtggaccg cagcaagaac      300

accctgtacc tgcagatgaa cagcctgcgc gccgaggaca ccgccgtgta ctactgcgcc      360

cgcaacctgg gccccagctt ctacttcgac tattgggggc agggcaccct ggtcaccgtg      420

agcagcgcta gcaccaaggg cccatccgtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagctgccct gggctgcctg gtcaaggact acttccccga accagtgacc      540

gtgtcctgga actcaggcgc cctgaccagc ggcgtgcaca ccttccctgc tgtcctgcag      600

tcctcaggac tctactccct cagcagcgtg gtgactgtgc cctctagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgataa aactcatacc tgcccccctt gtcctgcacc agaactgctg      780

ggaggaccat ccgtgttcct gtttccaccc aagcctaaag acaccctgat gatttcccgc      840

acacccgagg tcacttgcgt ggtcgtggac gtgtctcacg aggaccccga agtcaagttc      900

aactggtacg tggatggcgt cgaagtgcat aatgctaaga ccaaaccaag ggaggaacag      960

tacaactcca catatcgcgt cgtgtctgtc ctgactgtgc tgcaccagga ttggctgaac     1020

ggcaaagagt ataagtgcaa agtgagcaat aaggccctgc ccgctcctat cgagaaaact     1080

attagcaagg ctaaagggca gcctcgcgaa ccacaggtgt acaccctgcc tccatctcgg     1140

gaggaaatga ctaagaacca agtcagtctg acctgtctgg tgaaagggtt ctatcctagc     1200

gacattgcag tggagtggga atccaatgga cagccagaga acaattacaa gaccacaccc     1260

cctgtgctgg actcagatgg aagcttcttt ctgtatagta agctgaccgt ggataaatca     1320

cgctggcagc agggcaacgt cttttcttgt agtgtgctgc atgaagccct gcacaatcat     1380

tacacacaga agtcactgag cctgtcccct ggcggcggag ggagcggcgg aggctccgga     1440

ggcggcagcg gaggcggaga ggtgcagctg gtggagtctg gaggagggct ggtgcagcca     1500

ggagggtccc tgagactgtc ttgcgccgct agtggcttca acatcaagga cacctacatc     1560

cactgggtga gacaggcccc cggaaaaggc ctggagtggg tggccaggat ctaccctacc     1620

accggctaca ccaggtacgc cgacagcgtg aagggcaggt tcaccatcag cgccgacacc     1680

agcaagaaca ccgcctacct gcagatgaac agcctgaggg ccgaggacac cgccgtgtac     1740

tactgcagca gatggggcgg cagcggcttc tacgccatgg actactgggg acagggcaca     1800

ctggtcactg tgtctagtgc ctcaacaaag gggcctagcg tgtttccact ggctccctca     1860

agcaaaagca cttccggagg caccgctgca ctgggatgtc tggtgaagga ctacttccca     1920

gagcccgtca ccgtgtcttg gaacagtggg gctctgacca gcggagtcca cacatttcct     1980

gcagtgctgc agtcctctgg cctgtacagc ctgagttcag tggtcacagt cccaagctcc     2040

tctctgggga cccagacata tatctgcaac gtgaatcaca agccaagcaa tactaaagtc     2100

gacaagaaag tggagcccaa gagctgt                                         2127


<210>  41
<211>  1426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pert_HC_v16x Knob

<400>  41
gaattcgcca ccatgaactt tggcctgagc ctgatttttc tcgtcctgat cctgaagggc       60

gtgcagtgtg aggtgcagct ggtggagagc ggcggcggcc tggtgcagcc cggcggcagc      120

ctgcgcctgt cctgcgccgc cagcggcttc acctttaccg actacaccat ggactgggtg      180

cgccaggctc ccggcaaggg cctggagtgg gtggccgacg tgaaccccaa cagcggcggc      240

agcatctaca accagcgctt caagggccgc ttcaccctga gcgtggaccg cagcaagaac      300

accctgtacc tgcagatgaa cagcctgcgc gccgaggaca ccgccgtgta ctactgcgcc      360

cgcaacctgg gccccagctt ctacttcgac tattgggggc agggcaccct ggtcaccgtg      420

agcagcgcta gcaccaaggg cccatccgtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagctgccct gggctgcctg gtcaaggact acttccccga accagtgacc      540

gtgtcctgga actcaggcgc cctgaccagc ggcgtgcaca ccttccctgc tgtcctgcag      600

tcctcaggac tctactccct cagcagcgtg gtgactgtgc cctctagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgataa aactcatacc tgcccccctt gtcctgcacc agaactgctg      780

ggaggaccat ccgtgttcct gtttccaccc aagcctaaag acaccctgat gatttcccgc      840

acacccgagg tcacttgcgt ggtcgtggac gtgtctcacg aggaccccga agtcaagttc      900

aactggtacg tggatggcgt cgaagtgcat aatgctaaga ccaaaccaag ggaggaacag      960

tacaactcca catatcgcgt cgtgtctgtc ctgactgtgc tgcaccagga ttggctgaac     1020

ggcaaagagt ataagtgcaa agtgagcaat aaggccctgc ccgctcctat cgagaaaact     1080

attagcaagg ctaaagggca gcctcgcgaa ccacaggtgt acaccctgcc tccatctcgg     1140

gaggaaatga ctaagaacca agtcagtctg tggtgtctgg tgaaagggtt ctatcctagc     1200

gacattgcag tggagtggga atccaatgga cagccagaga acaattacaa gaccacaccc     1260

cctgtgctgg actcagatgg aagcttcttt ctgtatagta agctgaccgt ggataaatca     1320

cgctggcagc agggcaacgt cttttcttgt agtgtgctgc atgaagccct gcacaatcat     1380

tacacacaga agtcactgag cctgtcccct ggcaaatgaa ggatcc                    1426


<210>  42
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tras-optimized Fc

<400>  42
atgaactttg gcctgagcct gatttttctc gtcctgatcc tgaagggcgt gcagtgtgag       60

gtgcagctgg tggagagcgg cggcggcctg gtgcagcccg gcggcagcct gcgcctgtcc      120

tgcgccgcca gcggcttcac ctttgccgac tacaccatgg actgggtgcg ccaggctccc      180

ggcaagggcc tggagtgggt ggccgacgtg aaccccaaca gcggcgccag catctacaac      240

cagcgcttca agggccgctt caccctgagc gtggaccgca gcaagaacac cctgtacctg      300

cagatgaaca gcctgcgcgc cgaggacacc gccgtgtact actgcgcccg caacctgggc      360

cccagcttct acttcgacta ttgggggcag ggcaccctgg tcaccgtgag cagcgctagc      420

accaagggcc catccgtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gctgccctgg gctgcctggt caaggactac ttccccgaac cagtgaccgt gtcctggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttccctgctg tcctgcagtc ctcaggactc      600

tactccctca gcagcgtggt gactgtgccc tctagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaag gcggagggag cggcggaggc tccggaggcg gcagcggagg cgga            774


<210>  43
<211>  1429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tras_HC_hole

<400>  43
gaattcgcca ccatgaactt tggcctgagc ctgatttttc tcgtcctgat cctgaagggc       60

gtgcagtgtg aggtgcagct ggtggagtct ggaggagggc tggtgcagcc aggagggtcc      120

ctgagactgt cttgcgccgc tagtggcttc aacatcaagg acacctacat ccactgggtg      180

agacaggccc ccggaaaagg cctggagtgg gtggccagga tctaccctac caccggctac      240

accaggtacg ccgacagcgt gaagggcagg ttcaccatca gcgccgacac cagcaagaac      300

accgcctacc tgcagatgaa cagcctgagg gccgaggaca ccgccgtgta ctactgcagc      360

agatggggcg gcagcggctt ctacgccatg gactactggg gacagggcac actggtcact      420

gtgtctagtg cctcaacaaa ggggcctagc gtgtttccac tggctccctc aagcaaaagc      480

acttccggag gcaccgctgc actgggatgt ctggtgaagg actacttccc agagcccgtc      540

accgtgtctt ggaacagtgg ggctctgacc agcggagtcc acacatttcc tgcagtgctg      600

cagtcctctg gcctgtacag cctgagttca gtggtcacag tcccaagctc ctctctgggg      660

acccagacat atatctgcaa cgtgaatcac aagccaagca atactaaagt cgacaagaaa      720

gtggagccca agagctgtga taaaactcat acctgccccc cttgtcctgc accagaactg      780

ctgggaggac catccgtgtt cctgtttcca cccaagccta aagacaccct gatgatttcc      840

cgcacacccg aggtcacttg cgtggtcgtg gacgtgtctc acgaggaccc cgaagtcaag      900

ttcaactggt acgtggatgg cgtcgaagtg cataatgcta agaccaaacc aagggaggaa      960

cagtacaact ccacatatcg cgtcgtgtct gtcctgactg tgctgcacca ggattggctg     1020

aacggcaaag agtataagtg caaagtgagc aataaggccc tgcccgctcc tatcgagaaa     1080

actattagca aggctaaagg gcagcctcgc gaaccacagg tgtacaccct gcctccatct     1140

cgggaggaaa tgactaagaa ccaagtcagt ctgagctgtg ccgtgaaagg gttctatcct     1200

agcgacattg cagtggagtg ggaatccaat ggacagccag agaacaatta caagaccaca     1260

ccccctgtgc tggactcaga tggaagcttc tttctggtga gtaagctgac cgtggataaa     1320

tcacgctggc agcagggcaa cgtcttttct tgtagtgtgc tgcatgaagc cctgcacaat     1380

cattacacac agaagtcact gagcctgtcc cctggcaaat gaaggatcc                 1429


<210>  44
<211>  1360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gTra_HC_vNT_DT_ML minus signal peptide

<400>  44
gaggtgcagc tggtggagtc tggaggaggg ctggtgcagc caggagggtc cctgagactg       60

tcttgcgccg ctagtggctt caacatcaag gacacctaca tccactgggt gagacaggcc      120

cccggaaaag gcctggagtg ggtggccagg atctacccta ccaccggcta caccaggtac      180

gccgacagcg tgaagggcag gttcaccatc agcgccgaca ccagcaagaa caccgcctac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcag cagatggggc      300

ggcaccggct tctacgccat ggactactgg ggacagggca cactggtcac tgtgtctagt      360

gcctcaacaa aggggcctag cgtgtttcca ctggctccct caagcaaaag cacttccgga      420

ggcaccgctg cactgggatg tctggtgaag gactacttcc cagagcccgt caccgtgtct      480

tggaacagtg gggctctgac cagcggagtc cacacatttc ctgcagtgct gcagtcctct      540

ggcctgtaca gcctgagttc agtggtcaca gtcccaagct cctctctggg gacccagaca      600

tatatctgca acgtgaatca caagccaagc aatactaaag tcgacaagaa agtggagccc      660

aagagctgtg ataaaactca tacctgcccc ccttgtcctg caccagaact gctgggagga      720

ccatccgtgt tcctgtttcc acccaagcct aaagacaccc tgatgatttc ccgcacaccc      780

gaggtcactt gcgtggtcgt ggacgtgtct cacgaggacc ccgaagtcaa gttcaactgg      840

tacgtggatg gcgtcgaagt gcataatgct aagaccaaac caagggagga acagtacaac      900

tccacatatc gcgtcgtgtc tgtcctgact gtgctgcacc aggattggct gaacggcaaa      960

gagtataagt gcaaagtgag caataaggcc ctgcccgctc ctatcgagaa aactattagc     1020

aaggctaaag ggcagcctcg cgaaccacag gtgtacaccc tgcctccatc tcgggaggaa     1080

atgactaaga accaagtcag tctgacctgt ctggtgaaag ggttctatcc tagcgacatt     1140

gcagtggagt gggaatccaa tggacagcca gagaacaatt acaagaccac accccctgtg     1200

ctggactcag atggaagctt ctttctgtat agtaagctga ccgtggataa atcacgctgg     1260

cagcagggca acgtcttttc ttgtagtgtg ctgcatgaag ccctgcacaa tcattacaca     1320

cagaagtcac tgagcctgtc ccctggcaaa tgaaggatcc                           1360


