                         SEQUENCE LISTING

<110>  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
 
<120>  ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF

<130>  6923-269-228

<140>  To Be Assigned
<141>  Herewith

<150>  US 62/483,262
<151>  2017-04-07

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH

<400>  1

Gln Val His Leu Gln Gln Ser Gly Pro Glu Val Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Lys Gln Arg Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile His Pro Gly Ser Thr Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ile Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Val Cys Trp 
            100                 105                 110         


Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL

<400>  2

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Val Thr Asn 
            20                  25                  30          


Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Cys Cys Gln Gln Tyr His Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
            100                 105         


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HCDR1 (IMGT)

<400>  3

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HCDR2 (IMGT)

<400>  4

Ile His Pro Gly Ser Thr Asn Thr 
1               5               


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 HCDR3 (IMGT)

<400>  5

Ala Ile Ser Leu Gly Asp Gly Tyr Tyr Val Tyr Ala Met Val Cys 
1               5                   10                  15  


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LCDR1 (IMGT)

<400>  6

Gln Asn Val Val Thr Asn 
1               5       


<210>  7
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LCDR2 (IMGT)

<400>  7

Ser Ala Ser 
1           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 LCDR3 (IMGT)

<400>  8

Gln Gln Tyr His Ser Tyr Pro Phe Thr 
1               5                   


<210>  9
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH FR1 (IMGT)

<400>  9

Gln Val His Leu Gln Gln Ser Gly Pro Glu Val Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH FR2 (IMGT)

<400>  10

Leu Asn Trp Val Lys Gln Arg Pro Arg Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gln 
    


<210>  11
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH FR3 (IMGT)

<400>  11

Tyr Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VH FR4 (IMGT)

<400>  12

Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
1               5                   10      


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL FR1 (IMGT)

<400>  13

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser 
            20                  25      


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL FR2 (IMGT)

<400>  14

Val Val Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  15
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL FR3 (IMGT)

<400>  15

Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala 
            20                  25                  30          


Glu Tyr Cys Cys 
        35      


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F2 VL FR4 (IMGT)

<400>  16

Phe Gly Ser Gly Thr Lys Leu Glu Val Lys 
1               5                   10  


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VH

<400>  17

Gln Val His Leu Gln Gln Ser Gly Ser Glu Leu Arg Ser Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Asp Phe Asp Ser Glu Val Phe Pro Ile 
            20                  25                  30          


Val Tyr Met Arg Trp Ile Arg Gln Lys Pro Gly His Gly Phe Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Leu Pro Ser Phe Gly Arg Thr Ile Tyr Gly Glu Lys 
    50                  55                  60                  


Phe Glu Asp Lys Ala Thr Leu Asp Ala Asp Thr Val Ser Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Asp His Gly Asn Trp Leu Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VL

<400>  18

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asn Arg Phe Thr Gly 
    50                  55                  60                  


Ile Ile Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Arg Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 HCDR1 (IMGT)

<400>  19

Asp Ser Glu Val Phe Pro Ile Val Tyr 
1               5                   


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 HCDR2 (IMGT)

<400>  20

Ile Leu Pro Ser Phe Gly Arg Thr 
1               5               


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 HCDR3 (IMGT)

<400>  21

Ala Arg Gly Asp His Gly Asn Trp Leu Ala Tyr 
1               5                   10      


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 LCDR1 (IMGT)

<400>  22

Gln Asp Val Ser Thr Asn 
1               5       


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 LCDR2 (IMGT)

<400>  23

Trp Ala Ser 
1           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 LCDR3 (IMGT)

<400>  24

Gln Gln His Tyr Ser Ala Pro Trp Thr 
1               5                   


<210>  25
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VH FR1 (IMGT)

<400>  25

Gln Val His Leu Gln Gln Ser Gly Ser Glu Leu Arg Ser Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Asp Phe 
            20                  25  


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VH FR2 (IMGT)

<400>  26

Met Arg Trp Ile Arg Gln Lys Pro Gly His Gly Phe Glu Trp Ile Gly 
1               5                   10                  15      


Asp 
    


<210>  27
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VH FR3 (IMGT)

<400>  27

Ile Tyr Gly Glu Lys Phe Glu Asp Lys Ala Thr Leu Asp Ala Asp Thr 
1               5                   10                  15      


Val Ser Asn Thr Ala Tyr Leu Glu Leu Asn Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Ile Tyr Tyr Cys 
        35              


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VH FR4 (IMGT)

<400>  28

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  29
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VL FR1 (IMGT)

<400>  29

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VL FR2 (IMGT)

<400>  30

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  31
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VL FR3 (IMGT)

<400>  31

Thr Arg His Thr Gly Val Pro Asn Arg Phe Thr Gly Ile Ile Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Arg Ala 
            20                  25                  30          


Leu Tyr Tyr Cys 
        35      


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1F4 VL FR4 (IMGT)

<400>  32

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  33
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VH

<400>  33

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Cys 
        35                  40                  45              


Gly Glu Ile Phe Pro Gly Ser Gly Ser Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Asp Tyr Tyr Gly Ser Ser Tyr Gly Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 
        115                 120             


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VL

<400>  34

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Glu Lys Pro Gly Arg Thr Asn Lys Val Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Ile Leu Ser Phe Gly Asn Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 HCDR1 (IMGT)

<400>  35

Gly Tyr Lys Phe Thr Ser Tyr Trp 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 HCDR2 (IMGT)

<400>  36

Ile Phe Pro Gly Ser Gly Ser Ile 
1               5               


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 HCDR3 (IMGT)

<400>  37

Ala Arg Gly Glu Asp Tyr Tyr Gly Ser Ser Tyr Gly Ala Met Asp Tyr 
1               5                   10                  15      


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 LCDR1 (IMGT)

<400>  38

Lys Ser Ile Ser Lys Tyr 
1               5       


<210>  39
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 LCDR2 (IMGT)

<400>  39

Ser Gly Ser 
1           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 LCDR3 (IMGT)

<400>  40

Gln Gln His Asn Glu Tyr Pro Trp Thr 
1               5                   


<210>  41
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VH FR1 (IMGT)

<400>  41

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr 
            20                  25  


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VH FR2 (IMGT)

<400>  42

Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Cys Gly 
1               5                   10                  15      


Glu 
    


<210>  43
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VH FR3 (IMGT)

<400>  43

Asn Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asn Thr Ala Tyr Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VH FR4 (IMGT)

<400>  44

Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 
1               5                   10      


<210>  45
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VL FR1 (IMGT)

<400>  45

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser 
            20                  25      


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VL FR2 (IMGT)

<400>  46

Val Ala Trp Tyr Gln Glu Lys Pro Gly Arg Thr Asn Lys Val Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  47
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VL FR3 (IMGT)

<400>  47

Ile Leu Ser Phe Gly Asn Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
            20                  25                  30          


Met Tyr Tyr Cys 
        35      


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G1 VL FR4 (IMGT)

<400>  48

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  49
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VH

<400>  49

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Pro Met His Trp Val Lys Gln Ala Pro Gly Lys Ser Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Glu Glu Pro Thr Tyr Ser Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Ser Pro Leu Ser Leu Glu Thr Ser Ala Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ser Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Ser Gly Tyr Tyr Tyr Gly Ser Thr Tyr Ala Trp Phe Gly Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120             


<210>  50
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VL

<400>  50

Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile His Thr 
            20                  25                  30          


Asn Gly Asp Thr Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Ala Leu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105                 110         


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 HCDR1 (IMGT)

<400>  51

Gly Phe Thr Phe Thr Asp Tyr Pro 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 HCDR2 (IMGT)

<400>  52

Ile Asn Thr Glu Thr Glu Glu Pro 
1               5               


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 HCDR3 (IMGT)

<400>  53

Val Arg Ser Gly Tyr Tyr Tyr Gly Ser Thr Tyr Ala Trp Phe Gly Tyr 
1               5                   10                  15      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 LCDR1 (IMGT)

<400>  54

Gln Ser Leu Ile His Thr Asn Gly Asp Thr Phe 
1               5                   10      


<210>  55
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 LCDR2 (IMGT)

<400>  55

Lys Val Ser 
1           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 LCDR3 (IMGT)

<400>  56

Ser Gln Ser Ala Leu Phe Pro Tyr Thr 
1               5                   


<210>  57
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VH FR1 (IMGT)

<400>  57

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VH FR2 (IMGT)

<400>  58

Met His Trp Val Lys Gln Ala Pro Gly Lys Ser Leu Lys Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  59
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VH FR3 (IMGT)

<400>  59

Thr Tyr Ser Asp Asp Phe Lys Gly Arg Ser Pro Leu Ser Leu Glu Thr 
1               5                   10                  15      


Ser Ala Ser Thr Thr Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            20                  25                  30          


Thr Ser Thr Tyr Phe Cys 
        35              


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VH FR4 (IMGT)

<400>  60

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  61
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VL FR1 (IMGT)

<400>  61

Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  62
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VL FR2 (IMGT)

<400>  62

Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  63
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VL FR3 (IMGT)

<400>  63

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Thr Gly Gly Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            20                  25                  30          


Ile Tyr Phe Cys 
        35      


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4B2 VL FR4 (IMGT)

<400>  64

Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
1               5                   10  


<210>  65
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VH

<400>  65

Asp Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Thr Gly Gly Ser Phe Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Thr Arg Val Ser Asp Tyr Gly Asn Ser Ala Tyr Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Ile Val Phe Ala 
        115                 120     


<210>  66
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VL

<400>  66

Gln Val Val Leu Thr Gln Ser Pro Ala Leu Ile Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Asn Val Asn Tyr Met 
            20                  25                  30          


Ser Trp Tyr Gln Gln Arg Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Lys Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asp Pro Gln Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 HCDR1 (IMGT)

<400>  67

Gly Phe Thr Phe Ser Ala Tyr Ser 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 HCDR2 (IMGT)

<400>  68

Ile Asn Thr Gly Gly Ser Phe Thr 
1               5               


<210>  69
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 HCDR3 (IMGT)

<400>  69

Thr Arg Val Ser Asp Tyr Gly Asn Ser Ala Tyr Phe Pro Tyr 
1               5                   10                  


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 LCDR1 (IMGT)

<400>  70

Ser Asn Val Asn Tyr 
1               5   


<210>  71
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 LCDR2 (IMGT)

<400>  71

Leu Thr Ser 
1           


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 LCDR3 (IMGT)

<400>  72

Gln Gln Trp Ser Ser Asp Pro Gln Thr 
1               5                   


<210>  73
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VH FR1 (IMGT)

<400>  73

Asp Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  74
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VH FR2 (IMGT)

<400>  74

Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  75
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VH FR3 (IMGT)

<400>  75

Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            20                  25                  30          


Thr Ala Met Tyr Phe Cys 
        35              


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VH FR4 (IMGT)

<400>  76

Trp Gly Gln Gly Thr Leu Val Ile Val Phe Ala 
1               5                   10      


<210>  77
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VL FR1 (IMGT)

<400>  77

Gln Val Val Leu Thr Gln Ser Pro Ala Leu Ile Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VL FR2 (IMGT)

<400>  78

Met Ser Trp Tyr Gln Gln Arg Pro Arg Ser Ser Pro Lys Pro Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  79
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VL FR3 (IMGT)

<400>  79

Lys Leu Ala Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4F11 VL FR4 (IMGT)

<400>  80

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  81
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1F2 VH

<400>  81
caggttcacc tgcagcagtc tggacctgag gtggcgaggc ccggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcact gactactatc ttaactgggt gaagcagagg      120

cctagacagg gccttgagtg gattggacag attcatcctg gaagtactaa tacttactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atttgaggac tctgcagtct atttctgtgc aatatccctt      300

ggtgatggtt actacgtcta tgctatggtc tgctggggtc agggaaccgc agtcaccgtc      360

tcctca                                                                 366


<210>  82
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1F2 VL

<400>  82
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtggtt actaatgtag tctggtatca acagaaacca      120

ggtcagtctc ctaaaccact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtactg ctgtcagcaa tatcacagct atccattcac gttcggctcg      300

gggacaaagt tggaagtaaa a                                                321


<210>  83
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1F4 VH

<400>  83
caggttcacc tacaacagtc tggttctgaa ctgaggagtc ctgggtcttc agtaaagctt       60

tcatgcaagg attttgattc agaagtcttc cctattgttt atatgagatg gattaggcag      120

aagcctggcc atggatttga atggattgga gacatactcc caagttttgg tagaacaatc      180

tatggagaga agtttgagga caaagccaca ctagatgcag acacagtgtc caacacagcc      240

tacttggagc tcaacagtct gacatctgag gactctgcta tctactactg tgcaaggggg      300

gaccatggta actggcttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  84
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1F4 VL

<400>  84
gacattgtga tgacccagtc tcacaaattc atgtccacat cagttggaga cagggtcacc       60

atcacctgca aggccagtca ggatgtgagt actaatgtag cctggtatca acaaaaacca      120

ggccaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctaat      180

cgcttcacag gcattatatc tgggacagat tacactctca ctatcagcag tgtgcaggct      240

gaagaccggg cactttatta ctgtcagcaa cattatagcg ctccgtggac gttcggagga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  85
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3G1 VH

<400>  85
caggttcagc tgcagcagtc tggagctgaa ttgatgaagc ctggggcctc agtgaagatt       60

tcctgcaagg ctactgggta caaattcact agttattgga tagggtgggt aaagcagagg      120

ccgggacatg gccttgagtg gtgtggagag atttttcctg gaagtggcag tattaactat      180

aatgagaaat ttaagggcaa ggccacattc actgcagata catcctccaa cacagcctac      240

ttgcaactga ccagcctgac atctgaggac tctgccgtct attactgtgc aagaggggag      300

gattattacg gtagtagtta cggtgctatg gactactggg gtcaaggaac ctcactcacc      360

gtctcctca                                                              369


<210>  86
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3G1 VL

<400>  86
gatgtccaga taacccagtc tccatcttat cttgctgcat ctcctggaga aaccattact       60

attaattgca gggcaagtaa gagcatcagc aaatatgtag cctggtatca agagaaacct      120

gggagaacta acaaggttct tatatattct ggatcaatct tgtcatttgg aaatccatca      180

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      240

gaagattttg caatgtatta ctgtcaacag cataatgaat acccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  87
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B2 VH

<400>  87
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggttt taccttcaca gactatccaa tgcactgggt gaagcaggct      120

ccaggaaaga gtttaaagtg gatgggttgg ataaacactg agactgaaga gccaacatat      180

tcagatgact tcaagggacg gtctcccttg tctttggaaa cctctgccag cacaacttat      240

ttgcagatca acaatctcaa aaatgaggac acgtctacat atttctgtgt tagatcaggt      300

tattactatg gtagtaccta cgcctggttt ggttactggg gccaagggac tctggtcact      360

gtctctgca                                                              369


<210>  88
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4B2 VL

<400>  88
gatgttgtga tgacccaaat tccactctcc ctgcctgtca gtctcggaga tcaggcctcc       60

atctcttgca gatctagtca gagccttata cacactaatg gagacacctt tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cactggcggt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggaatt tatttctgct ctcaaagtgc actttttccg      300

tacacgttcg gaggggggac caacctggaa ataaaa                                336


<210>  89
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4F11 VH

<400>  89
gacgtgaaac tggtggaatc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt gcctattcca tgtcttgggt tcgccagact      120

ccggagagga ggctggagtg ggtcgcaacc attaatactg gtggtagttt cacctactat      180

ccagacagtg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt atttctgtac aagagtttcc      300

gactacggta atagcgccta ctttccttac tggggccaag ggactctggt cattgtcttt      360

gca                                                                    363


<210>  90
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4F11 VL

<400>  90
caagttgttc tcacccagtc tccagcactc atatctgcgt ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aaatgtaaat tacatgtcct ggtaccagca gaggccaaga      120

tcctccccca aaccctggat ttatctcaca tccaaactgg cttctggagt ccctcctcgt      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgttgcca cttattactg ccagcagtgg agcagtgacc cccagacgtt cggagggggg      300

accaaggtgg aaataaaa                                                    318


<210>  91
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' consensus anchor primer


<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  where n is c, u or a

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  where n is c, u or a

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  where n is c, u or a

<400>  91
ggccacgcgt cgactagtac gggnngggnn gggnng                                 36


<210>  92
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Constant region specific reverse primer IgG2a

<400>  92
ccttgaccag gcatcctaga gtc                                               23


<210>  93
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Constant region specific reverse primer IgG2b

<400>  93
ggaggtgtgc acactgctgg acag                                              24


