                         SEQUENCE LISTING

<110>  University of Massachusetts
 
<120>  MINIGENE THERAPY

<130>  U0120.70089WO00

<140>  Not Yet Assigned
<141>  Concurrently herewith

<150>  US 62/481,727
<151>  2017-04-05

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  2479
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Asn Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu 
    610                 615                 620                 


Arg Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu 
625                 630                 635                 640 


Val Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln 
                645                 650                 655     


Ala Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr 
            660                 665                 670         


Ser Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser 
        675                 680                 685             


Lys Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln 
    690                 695                 700                 


Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg 
705                 710                 715                 720 


Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala 
                725                 730                 735     


Asn Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln 
            740                 745                 750         


Ser Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly 
        755                 760                 765             


Ile Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu 
    770                 775                 780                 


Ile His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg 
                805                 810                 815     


His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr 
            820                 825                 830         


Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu 
        835                 840                 845             


Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu 
    850                 855                 860                 


Leu Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu 
                885                 890                 895     


Ile Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys 
            900                 905                 910         


Glu Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val 
        915                 920                 925             


Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe 
    930                 935                 940                 


Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser 
945                 950                 955                 960 


Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr 
                965                 970                 975     


Arg Asp Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn 
            980                 985                 990         


Leu Glu His Leu Glu Cys Glu Asn  Ile Ser Leu Lys Glu  Gln Val Glu 
        995                 1000                 1005             


Ser Ile  Asn Lys Glu Leu Glu  Ile Thr Lys Glu Lys  Leu His Thr 
    1010                 1015                 1020             


Ile Glu  Gln Ala Trp Glu Gln  Glu Thr Lys Leu Gly  Asn Glu Ser 
    1025                 1030                 1035             


Ser Met  Asp Lys Ala Lys Lys  Ser Ile Thr Asn Ser  Asp Ile Val 
    1040                 1045                 1050             


Ser Ile  Ser Lys Lys Ile Thr  Met Leu Glu Met Lys  Glu Leu Asn 
    1055                 1060                 1065             


Glu Arg  Gln Arg Ala Glu His  Cys Gln Lys Met Tyr  Glu His Leu 
    1070                 1075                 1080             


Arg Thr  Ser Leu Lys Gln Met  Glu Glu Arg Asn Phe  Glu Leu Glu 
    1085                 1090                 1095             


Thr Lys  Phe Ala Glu Leu Thr  Lys Ile Asn Leu Asp  Ala Gln Lys 
    1100                 1105                 1110             


Val Glu  Gln Met Leu Arg Asp  Glu Leu Ala Asp Ser  Val Ser Lys 
    1115                 1120                 1125             


Ala Val  Ser Asp Ala Asp Arg  Gln Arg Ile Leu Glu  Leu Glu Lys 
    1130                 1135                 1140             


Asn Glu  Met Glu Leu Lys Val  Glu Val Ser Lys Leu  Arg Glu Ile 
    1145                 1150                 1155             


Ser Asp  Ile Ala Arg Arg Gln  Val Glu Ile Leu Asn  Ala Gln Gln 
    1160                 1165                 1170             


Gln Ser  Arg Asp Lys Glu Val  Glu Ser Leu Arg Met  Gln Leu Leu 
    1175                 1180                 1185             


Asp Tyr  Gln Ala Gln Ser Asp  Glu Lys Ser Leu Ile  Ala Lys Leu 
    1190                 1195                 1200             


His Gln  His Asn Val Ser Leu  Gln Leu Ser Glu Ala  Thr Ala Leu 
    1205                 1210                 1215             


Gly Lys  Leu Glu Ser Ile Thr  Ser Lys Leu Gln Lys  Met Glu Ala 
    1220                 1225                 1230             


Tyr Asn  Leu Arg Leu Glu Gln  Lys Leu Asp Glu Lys  Glu Gln Ala 
    1235                 1240                 1245             


Leu Tyr  Tyr Ala Arg Leu Glu  Gly Arg Asn Arg Ala  Lys His Leu 
    1250                 1255                 1260             


Arg Gln  Thr Ile Gln Ser Leu  Arg Arg Gln Phe Ser  Gly Ala Leu 
    1265                 1270                 1275             


Pro Leu  Ala Gln Gln Glu Lys  Phe Ser Lys Thr Met  Ile Gln Leu 
    1280                 1285                 1290             


Gln Asn  Asp Lys Leu Lys Ile  Met Gln Glu Met Lys  Asn Ser Gln 
    1295                 1300                 1305             


Gln Glu  His Arg Asn Met Glu  Asn Lys Thr Leu Glu  Met Glu Leu 
    1310                 1315                 1320             


Lys Leu  Lys Gly Leu Glu Glu  Leu Ile Ser Thr Leu  Lys Asp Thr 
    1325                 1330                 1335             


Lys Gly  Ala Gln Lys Val Ile  Asn Trp His Met Lys  Ile Glu Glu 
    1340                 1345                 1350             


Leu Arg  Leu Gln Glu Leu Lys  Leu Asn Arg Glu Leu  Val Lys Asp 
    1355                 1360                 1365             


Lys Glu  Glu Ile Lys Tyr Leu  Asn Asn Ile Ile Ser  Glu Tyr Glu 
    1370                 1375                 1380             


Arg Thr  Ile Ser Ser Leu Glu  Glu Glu Ile Val Gln  Gln Asn Lys 
    1385                 1390                 1395             


Phe His  Glu Glu Arg Gln Met  Ala Trp Asp Gln Arg  Glu Val Asp 
    1400                 1405                 1410             


Leu Glu  Arg Gln Leu Asp Ile  Phe Asp Arg Gln Gln  Asn Glu Ile 
    1415                 1420                 1425             


Leu Asn  Ala Ala Gln Lys Phe  Glu Glu Ala Thr Gly  Ser Ile Pro 
    1430                 1435                 1440             


Asp Pro  Ser Leu Pro Leu Pro  Asn Gln Leu Glu Ile  Ala Leu Arg 
    1445                 1450                 1455             


Lys Ile  Lys Glu Asn Ile Arg  Ile Ile Leu Glu Thr  Arg Ala Thr 
    1460                 1465                 1470             


Cys Lys  Ser Leu Glu Glu Lys  Leu Lys Glu Lys Glu  Ser Ala Leu 
    1475                 1480                 1485             


Arg Leu  Ala Glu Gln Asn Ile  Leu Ser Arg Asp Lys  Val Ile Asn 
    1490                 1495                 1500             


Glu Leu  Arg Leu Arg Leu Pro  Ala Thr Ala Glu Arg  Glu Lys Leu 
    1505                 1510                 1515             


Ile Ala  Glu Leu Gly Arg Lys  Glu Met Glu Pro Lys  Ser His His 
    1520                 1525                 1530             


Thr Leu  Lys Ile Ala His Gln  Thr Ile Ala Asn Met  Gln Ala Arg 
    1535                 1540                 1545             


Leu Asn  Gln Lys Glu Glu Val  Leu Lys Lys Tyr Gln  Arg Leu Leu 
    1550                 1555                 1560             


Glu Lys  Ala Arg Glu Glu Gln  Arg Glu Ile Val Lys  Lys His Glu 
    1565                 1570                 1575             


Glu Asp  Leu His Ile Leu His  His Arg Leu Glu Leu  Gln Ala Asp 
    1580                 1585                 1590             


Ser Ser  Leu Asn Lys Phe Lys  Gln Thr Ala Trp Asp  Leu Met Lys 
    1595                 1600                 1605             


Gln Ser  Pro Thr Pro Val Pro  Thr Asn Lys His Phe  Ile Arg Leu 
    1610                 1615                 1620             


Ala Glu  Met Glu Gln Thr Val  Ala Glu Gln Asp Asp  Ser Leu Ser 
    1625                 1630                 1635             


Ser Leu  Leu Val Lys Leu Lys  Lys Val Ser Gln Asp  Leu Glu Arg 
    1640                 1645                 1650             


Gln Arg  Glu Ile Thr Glu Leu  Lys Val Lys Glu Phe  Glu Asn Ile 
    1655                 1660                 1665             


Lys Leu  Gln Leu Gln Glu Asn  His Glu Asp Glu Val  Lys Lys Val 
    1670                 1675                 1680             


Lys Ala  Glu Val Glu Asp Leu  Lys Tyr Leu Leu Asp  Gln Ser Gln 
    1685                 1690                 1695             


Lys Glu  Ser Gln Cys Leu Lys  Ser Glu Leu Gln Ala  Gln Lys Glu 
    1700                 1705                 1710             


Ala Asn  Ser Arg Ala Pro Thr  Thr Thr Met Arg Asn  Leu Val Glu 
    1715                 1720                 1725             


Arg Leu  Lys Ser Gln Leu Ala  Leu Lys Glu Lys Gln  Gln Lys Ala 
    1730                 1735                 1740             


Leu Ser  Arg Ala Leu Leu Glu  Leu Arg Ala Glu Met  Thr Ala Ala 
    1745                 1750                 1755             


Ala Glu  Glu Arg Ile Ile Ser  Ala Thr Ser Gln Lys  Glu Ala His 
    1760                 1765                 1770             


Leu Asn  Val Gln Gln Ile Val  Asp Arg His Thr Arg  Glu Leu Lys 
    1775                 1780                 1785             


Thr Gln  Val Glu Asp Leu Asn  Glu Asn Leu Leu Lys  Leu Lys Glu 
    1790                 1795                 1800             


Ala Leu  Lys Thr Ser Lys Asn  Arg Glu Asn Ser Leu  Thr Asp Asn 
    1805                 1810                 1815             


Leu Asn  Asp Leu Asn Asn Glu  Leu Gln Lys Lys Gln  Lys Ala Tyr 
    1820                 1825                 1830             


Asn Lys  Ile Leu Arg Glu Lys  Glu Glu Ile Asp Gln  Glu Asn Asp 
    1835                 1840                 1845             


Glu Leu  Lys Arg Gln Ile Lys  Arg Leu Thr Ser Gly  Leu Gln Gly 
    1850                 1855                 1860             


Lys Pro  Leu Thr Asp Asn Lys  Gln Ser Leu Ile Glu  Glu Leu Gln 
    1865                 1870                 1875             


Arg Lys  Val Lys Lys Leu Glu  Asn Gln Leu Glu Gly  Lys Val Glu 
    1880                 1885                 1890             


Glu Val  Asp Leu Lys Pro Met  Lys Glu Lys Asn Ala  Lys Glu Glu 
    1895                 1900                 1905             


Leu Ile  Arg Trp Glu Glu Gly  Lys Lys Trp Gln Ala  Lys Ile Glu 
    1910                 1915                 1920             


Gly Ile  Arg Asn Lys Leu Lys  Glu Lys Glu Gly Glu  Val Phe Thr 
    1925                 1930                 1935             


Leu Thr  Lys Gln Leu Asn Thr  Leu Lys Asp Leu Phe  Ala Lys Ala 
    1940                 1945                 1950             


Asp Lys  Glu Lys Leu Thr Leu  Gln Arg Lys Leu Lys  Thr Thr Gly 
    1955                 1960                 1965             


Met Thr  Val Asp Gln Val Leu  Gly Ile Arg Ala Leu  Glu Ser Glu 
    1970                 1975                 1980             


Lys Glu  Leu Glu Glu Leu Lys  Lys Arg Asn Leu Asp  Leu Glu Asn 
    1985                 1990                 1995             


Asp Ile  Leu Tyr Met Arg Ala  His Gln Ala Leu Pro  Arg Asp Ser 
    2000                 2005                 2010             


Val Val  Glu Asp Leu His Leu  Gln Asn Arg Tyr Leu  Gln Glu Lys 
    2015                 2020                 2025             


Leu His  Ala Leu Glu Lys Gln  Phe Ser Lys Asp Thr  Tyr Ser Lys 
    2030                 2035                 2040             


Pro Ser  Ile Ser Gly Ile Glu  Ser Asp Asp His Cys  Gln Arg Glu 
    2045                 2050                 2055             


Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu Ser Ser  Glu Asn Ile 
    2060                 2065                 2070             


Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn Lys Asp  Leu Pro Arg 
    2075                 2080                 2085             


Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu Met Cys  Glu Phe Leu 
    2090                 2095                 2100             


Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys Leu Gly  His Val Arg 
    2105                 2110                 2115             


Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro Glu Leu  Glu Lys Thr 
    2120                 2125                 2130             


Ile Gly  Leu Met Lys Lys Val  Val Glu Lys Val Gln  Arg Glu Asn 
    2135                 2140                 2145             


Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu Thr Ser  Glu Lys Met 
    2150                 2155                 2160             


Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu Lys Ala  Glu Leu Glu 
    2165                 2170                 2175             


Lys Leu  Lys Ala His Leu Gly  His Gln Leu Ser Met  His Tyr Glu 
    2180                 2185                 2190             


Ser Lys  Thr Lys Gly Thr Glu  Lys Ile Ile Ala Glu  Asn Glu Arg 
    2195                 2200                 2205             


Leu Arg  Lys Glu Leu Lys Lys  Glu Thr Asp Ala Ala  Glu Lys Leu 
    2210                 2215                 2220             


Arg Ile  Ala Lys Asn Asn Leu  Glu Ile Leu Asn Glu  Lys Met Thr 
    2225                 2230                 2235             


Val Gln  Leu Glu Glu Thr Gly  Lys Arg Leu Gln Phe  Ala Glu Ser 
    2240                 2245                 2250             


Arg Gly  Pro Gln Leu Glu Gly  Ala Asp Ser Lys Ser  Trp Lys Ser 
    2255                 2260                 2265             


Ile Val  Val Thr Arg Met Tyr  Glu Thr Lys Leu Lys  Glu Leu Glu 
    2270                 2275                 2280             


Thr Asp  Ile Ala Lys Lys Asn  Gln Ser Ile Thr Asp  Leu Lys Gln 
    2285                 2290                 2295             


Leu Val  Lys Glu Ala Thr Glu  Arg Glu Gln Lys Val  Asn Lys Tyr 
    2300                 2305                 2310             


Asn Glu  Asp Leu Glu Gln Gln  Ile Lys Ile Leu Lys  His Val Pro 
    2315                 2320                 2325             


Glu Gly  Ala Glu Thr Glu Gln  Gly Leu Lys Arg Glu  Leu Gln Val 
    2330                 2335                 2340             


Leu Arg  Leu Ala Asn His Gln  Leu Asp Lys Glu Lys  Ala Glu Leu 
    2345                 2350                 2355             


Ile His  Gln Ile Glu Ala Asn  Lys Asp Gln Ser Gly  Ala Glu Ser 
    2360                 2365                 2370             


Thr Ile  Pro Asp Ala Asp Gln  Leu Lys Glu Lys Ile  Lys Asp Leu 
    2375                 2380                 2385             


Glu Thr  Gln Leu Lys Met Ser  Asp Leu Glu Lys Gln  His Leu Lys 
    2390                 2395                 2400             


Glu Glu  Ile Lys Lys Leu Lys  Lys Glu Leu Glu Asn  Phe Asp Pro 
    2405                 2410                 2415             


Ser Phe  Phe Glu Glu Ile Glu  Asp Leu Lys Tyr Asn  Tyr Lys Glu 
    2420                 2425                 2430             


Glu Val  Lys Lys Asn Ile Leu  Leu Glu Glu Lys Val  Lys Lys Leu 
    2435                 2440                 2445             


Ser Glu  Gln Leu Gly Val Glu  Leu Thr Ser Pro Val  Ala Ala Ser 
    2450                 2455                 2460             


Glu Glu  Phe Glu Asp Glu Glu  Glu Ser Pro Val Asn  Phe Pro Ile 
    2465                 2470                 2475             


Tyr 
    


<210>  2
<211>  1116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg Lys Leu Asp 
1               5                   10                  15      


Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys Asn Glu Phe 
            20                  25                  30          


Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg Ser Arg 
        35                  40                  45              


Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val Glu Glu 
    50                  55                  60                  


Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala Ile Lys 
65                  70                  75                  80  


Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser Leu Ile 
                85                  90                  95      


Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys Asn Ala 
            100                 105                 110         


Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val Asp Gln 
        115                 120                 125             


Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg Glu Ser Arg 
    130                 135                 140                 


Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala Asn Leu Lys 
145                 150                 155                 160 


Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln Ser Glu Gly 
                165                 170                 175     


Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly Ile Ala Pro 
            180                 185                 190         


Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu Ile His Leu 
        195                 200                 205             


Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn Leu Glu Asp 
    210                 215                 220                 


Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg His Gln Gln 
225                 230                 235                 240 


Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr Trp Lys Thr 
                245                 250                 255     


Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu Asp Gln Val 
            260                 265                 270         


Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu Leu Asn Ala 
        275                 280                 285             


Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala Glu Asn Ser 
    290                 295                 300                 


Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu Ile Arg Gln 
305                 310                 315                 320 


Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys Glu Asn Glu 
                325                 330                 335     


Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val Cys Glu Lys 
            340                 345                 350         


Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe Lys Ile Ala 
        355                 360                 365             


Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser Glu Leu Glu 
    370                 375                 380                 


Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr Arg Asp Ile 
385                 390                 395                 400 


Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn Leu Glu His 
                405                 410                 415     


Leu Glu Cys Glu Asn Ile Ser Leu Lys Glu Gln Val Glu Ser Ile Asn 
            420                 425                 430         


Lys Glu Leu Glu Ile Thr Lys Glu Lys Leu His Thr Ile Glu Gln Ala 
        435                 440                 445             


Trp Glu Gln Glu Thr Lys Leu Gly Asn Glu Ser Ser Met Asp Lys Ala 
    450                 455                 460                 


Lys Lys Ser Ile Thr Asn Ser Asp Ile Val Ser Ile Ser Lys Lys Ile 
465                 470                 475                 480 


Thr Met Leu Glu Met Lys Glu Leu Asn Glu Arg Gln Arg Ala Glu His 
                485                 490                 495     


Cys Gln Lys Met Tyr Glu His Leu Arg Thr Ser Leu Lys Gln Met Glu 
            500                 505                 510         


Glu Arg Asn Phe Glu Leu Glu Thr Lys Phe Ala Glu Leu Thr Lys Ile 
        515                 520                 525             


Asn Leu Asp Ala Gln Lys Val Glu Gln Met Leu Arg Asp Glu Leu Ala 
    530                 535                 540                 


Asp Ser Val Ser Lys Ala Val Ser Asp Ala Asp Arg Gln Arg Ile Leu 
545                 550                 555                 560 


Glu Leu Glu Lys Asn Glu Met Glu Leu Lys Val Glu Val Ser Lys Leu 
                565                 570                 575     


Arg Glu Ile Ser Asp Ile Ala Arg Arg Gln Val Glu Ile Leu Asn Ala 
            580                 585                 590         


Gln Gln Gln Ser Arg Asp Lys Glu Val Glu Ser Leu Arg Met Gln Leu 
        595                 600                 605             


Leu Asp Tyr Gln Ala Gln Ser Asp Glu Lys Ser Leu Ile Ala Lys Leu 
    610                 615                 620                 


His Gln His Asn Val Ser Leu Gln Leu Ser Glu Ala Thr Ala Leu Gly 
625                 630                 635                 640 


Lys Leu Glu Ser Ile Thr Ser Lys Leu Gln Lys Met Glu Ala Tyr Asn 
                645                 650                 655     


Leu Arg Leu Glu Gln Lys Leu Asp Glu Lys Glu Gln Ala Leu Tyr Tyr 
            660                 665                 670         


Ala Arg Leu Glu Gly Arg Asn Arg Ala Lys His Leu Arg Gln Thr Ile 
        675                 680                 685             


Gln Ser Leu Arg Arg Gln Phe Ser Gly Ala Leu Pro Leu Ala Gln Gln 
    690                 695                 700                 


Glu Lys Phe Ser Lys Thr Met Ile Gln Leu Gln Asn Asp Lys Leu Lys 
705                 710                 715                 720 


Ile Met Gln Glu Met Lys Asn Ser Gln Gln Glu His Arg Asn Met Glu 
                725                 730                 735     


Asn Lys Thr Leu Glu Met Glu Leu Lys Leu Lys Gly Leu Glu Glu Leu 
            740                 745                 750         


Ile Ser Thr Leu Lys Asp Thr Lys Gly Ala Gln Lys Val Ile Asn Trp 
        755                 760                 765             


His Met Lys Ile Glu Glu Leu Arg Leu Gln Glu Leu Lys Leu Asn Arg 
    770                 775                 780                 


Glu Leu Val Lys Asp Lys Glu Glu Ile Lys Tyr Leu Asn Asn Ile Ile 
785                 790                 795                 800 


Ser Glu Tyr Glu Arg Thr Ile Ser Ser Leu Glu Glu Glu Ile Val Gln 
                805                 810                 815     


Gln Asn Lys Phe His Glu Glu Arg Gln Met Ala Trp Asp Gln Arg Glu 
            820                 825                 830         


Val Asp Leu Glu Arg Gln Leu Asp Ile Phe Asp Arg Gln Gln Asn Glu 
        835                 840                 845             


Ile Leu Asn Ala Ala Gln Lys Phe Glu Glu Ala Thr Gly Ser Ile Pro 
    850                 855                 860                 


Asp Pro Ser Leu Pro Leu Pro Asn Gln Leu Glu Ile Ala Leu Arg Lys 
865                 870                 875                 880 


Ile Lys Glu Asn Ile Arg Ile Ile Leu Glu Thr Arg Ala Thr Cys Lys 
                885                 890                 895     


Ser Leu Glu Glu Lys Leu Lys Glu Lys Glu Ser Ala Leu Arg Leu Ala 
            900                 905                 910         


Glu Gln Asn Ile Leu Ser Arg Asp Lys Val Ile Asn Glu Leu Arg Leu 
        915                 920                 925             


Arg Leu Pro Ala Thr Ala Glu Arg Glu Lys Leu Ile Ala Glu Leu Gly 
    930                 935                 940                 


Arg Lys Glu Met Glu Pro Lys Ser His His Thr Leu Lys Ile Ala His 
945                 950                 955                 960 


Gln Thr Ile Ala Asn Met Gln Ala Arg Leu Asn Gln Lys Glu Glu Val 
                965                 970                 975     


Leu Lys Lys Tyr Gln Arg Leu Leu Glu Lys Ala Arg Glu Glu Gln Arg 
            980                 985                 990         


Glu Ile Val Lys Lys His Glu Glu  Asp Leu His Ile Leu  His His Arg 
        995                 1000                 1005             


Leu Glu  Leu Gln Ala Asp Ser  Ser Leu Asn Lys Phe  Lys Gln Thr 
    1010                 1015                 1020             


Ala Trp  Asp Leu Met Lys Gln  Ser Pro Thr Pro Val  Pro Thr Asn 
    1025                 1030                 1035             


Lys His  Phe Ile Arg Leu Ala  Glu Met Glu Gln Thr  Val Ala Glu 
    1040                 1045                 1050             


Gln Asp  Asp Ser Leu Ser Ser  Leu Leu Val Lys Leu  Lys Lys Val 
    1055                 1060                 1065             


Ser Gln  Asp Leu Glu Arg Gln  Arg Glu Ile Thr Glu  Leu Lys Val 
    1070                 1075                 1080             


Lys Glu  Phe Glu Asn Ile Lys  Leu Gln Leu Gln Glu  Asn His Glu 
    1085                 1090                 1095             


Asp Glu  Val Lys Lys Val Lys  Ala Glu Val Glu Asp  Leu Lys Tyr 
    1100                 1105                 1110             


Leu Leu  Asp 
    1115     


<210>  3
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg Lys Leu Asp 
1               5                   10                  15      


Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys Asn Glu Phe 
            20                  25                  30          


Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu Arg Ser Arg 
        35                  40                  45              


Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu Val Glu Glu 
    50                  55                  60                  


Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln Ala Ile Lys 
65                  70                  75                  80  


Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr Ser Leu Ile 
                85                  90                  95      


Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser Lys Asn Ala 
            100                 105                 110         


Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln Val Asp Gln 
        115                 120                 125             


Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg Glu Ser Arg 
    130                 135                 140                 


Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala Asn Leu Lys 
145                 150                 155                 160 


Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln Ser Glu Gly 
                165                 170                 175     


Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly Ile Ala Pro 
            180                 185                 190         


Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu Ile His Leu 
        195                 200                 205             


Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn Leu Glu Asp 
    210                 215                 220                 


Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg His Gln Gln 
225                 230                 235                 240 


Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr Trp Lys Thr 
                245                 250                 255     


Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu Asp Gln Val 
            260                 265                 270         


Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu Leu Asn Ala 
        275                 280                 285             


Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala Glu Asn Ser 
    290                 295                 300                 


Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu Ile Arg Gln 
305                 310                 315                 320 


Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys Glu Asn Glu 
                325                 330                 335     


Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val Cys Glu Lys 
            340                 345                 350         


Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe Lys Ile Ala 
        355                 360                 365             


Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser Glu Leu Glu 
    370                 375                 380                 


Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr Arg Asp Ile 
385                 390                 395                 400 


Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn Leu Glu His 
                405                 410                 415     


Leu Glu Cys Glu Asn Ile Ser Leu Lys Glu Gln Val Glu Ser Ile Asn 
            420                 425                 430         


Lys Glu Leu Glu Ile Thr Lys Glu Lys Leu His Thr Ile Glu Gln Ala 
        435                 440                 445             


Trp Glu Gln Glu Thr Lys Leu Gly Asn Glu Ser Ser Met Asp Lys Ala 
    450                 455                 460                 


Lys Lys Ser Ile Thr Asn Ser Asp Ile Val Ser Ile Ser Lys Lys Ile 
465                 470                 475                 480 


Thr Met Leu Glu Met Lys Glu Leu Asn Glu Arg Gln Arg Ala Glu His 
                485                 490                 495     


Cys Gln Lys Met Tyr Glu His Leu Arg Thr Ser Leu Lys Gln Met Glu 
            500                 505                 510         


Glu Arg Asn Phe Glu Leu Glu Thr Lys Phe Ala Glu Leu Thr Lys Ile 
        515                 520                 525             


Asn Leu Asp Ala Gln Lys Val Glu Gln Met Leu Arg Asp Glu Leu Ala 
    530                 535                 540                 


Asp Ser Val Ser Lys Ala Val Ser Asp Ala Asp Arg Gln Arg Ile Leu 
545                 550                 555                 560 


Glu Leu Glu Lys Asn Glu Met Glu Leu Lys Val Glu Val Ser Lys Leu 
                565                 570                 575     


Arg Glu Ile Ser Asp Ile Ala Arg Arg Gln Val Glu Ile Leu Asn Ala 
            580                 585                 590         


Gln Gln Gln Ser Arg Asp Lys Glu Val 
        595                 600     


<210>  4
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Glu Ser Leu Arg Met Gln Leu Leu Asp Tyr Gln Ala Gln Ser Asp Glu 
1               5                   10                  15      


Lys Ser Leu Ile Ala Lys Leu His Gln His Asn Val Ser Leu Gln Leu 
            20                  25                  30          


Ser Glu Ala Thr Ala Leu Gly Lys Leu Glu Ser Ile Thr Ser Lys Leu 
        35                  40                  45              


Gln Lys Met Glu Ala Tyr Asn Leu Arg Leu Glu Gln Lys Leu Asp Glu 
    50                  55                  60                  


Lys Glu Gln Ala Leu Tyr Tyr Ala Arg Leu Glu Gly Arg Asn Arg Ala 
65                  70                  75                  80  


Lys His Leu Arg Gln Thr Ile Gln Ser Leu Arg Arg Gln Phe Ser Gly 
                85                  90                  95      


Ala Leu Pro Leu Ala Gln Gln Glu Lys Phe Ser Lys Thr Met Ile Gln 
            100                 105                 110         


Leu Gln Asn Asp Lys Leu Lys Ile Met Gln Glu Met Lys Asn Ser Gln 
        115                 120                 125             


Gln Glu His Arg Asn Met Glu Asn Lys Thr Leu Glu Met Glu Leu Lys 
    130                 135                 140                 


Leu Lys Gly Leu Glu Glu Leu Ile Ser Thr Leu Lys Asp Thr Lys Gly 
145                 150                 155                 160 


Ala Gln Lys Val Ile Asn Trp His Met Lys Ile Glu Glu Leu Arg Leu 
                165                 170                 175     


Gln Glu Leu Lys Leu Asn Arg Glu Leu Val Lys Asp Lys Glu Glu Ile 
            180                 185                 190         


Lys Tyr Leu Asn Asn Ile Ile Ser Glu Tyr Glu Arg Thr Ile Ser Ser 
        195                 200                 205             


Leu Glu Glu Glu Ile Val Gln Gln Asn Lys Phe His Glu Glu Arg Gln 
    210                 215                 220                 


Met Ala Trp Asp Gln Arg Glu Val Asp Leu Glu Arg Gln Leu Asp Ile 
225                 230                 235                 240 


Phe Asp Arg Gln Gln Asn Glu Ile Leu Asn Ala Ala Gln Lys Phe Glu 
                245                 250                 255     


Glu Ala Thr Gly Ser Ile Pro Asp Pro Ser Leu Pro Leu Pro Asn Gln 
            260                 265                 270         


Leu Glu Ile Ala Leu Arg Lys Ile Lys Glu Asn Ile Arg Ile Ile Leu 
        275                 280                 285             


Glu Thr Arg Ala Thr Cys Lys Ser Leu Glu Glu Lys Leu Lys Glu Lys 
    290                 295                 300                 


Glu Ser Ala Leu Arg Leu Ala Glu Gln Asn Ile Leu Ser Arg Asp Lys 
305                 310                 315                 320 


Val Ile Asn Glu Leu Arg Leu Arg Leu Pro Ala Thr Ala Glu Arg Glu 
                325                 330                 335     


Lys Leu Ile Ala Glu Leu Gly Arg Lys Glu Met Glu Pro Lys Ser His 
            340                 345                 350         


His Thr Leu Lys Ile Ala His Gln Thr Ile Ala Asn Met Gln Ala Arg 
        355                 360                 365             


Leu Asn Gln Lys Glu Glu Val Leu Lys Lys Tyr Gln Arg Leu Leu Glu 
    370                 375                 380                 


Lys Ala Arg Glu Glu Gln Arg Glu Ile Val Lys Lys His Glu Glu Asp 
385                 390                 395                 400 


Leu His Ile Leu His His Arg Leu Glu Leu Gln Ala Asp Ser Ser Leu 
                405                 410                 415     


Asn Lys Phe Lys Gln Thr Ala Trp Asp Leu Met Lys Gln Ser Pro Thr 
            420                 425                 430         


Pro Val Pro Thr Asn Lys His Phe Ile Arg Leu Ala Glu Met Glu Gln 
        435                 440                 445             


Thr Val Ala Glu Gln Asp Asp Ser Leu Ser Ser Leu Leu Val Lys Leu 
    450                 455                 460                 


Lys Lys Val Ser Gln Asp Leu Glu Arg Gln Arg Glu Ile Thr Glu Leu 
465                 470                 475                 480 


Lys Val Lys Glu Phe Glu Asn Ile Lys Leu Gln Leu Gln Glu Asn His 
                485                 490                 495     


Glu Asp Glu Val Lys Lys Val Lys Ala Glu Val Glu Asp Leu Lys Tyr 
            500                 505                 510         


Leu Leu Asp 
        515 


<210>  5
<211>  3606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
actgaaaaca tttctcaagg agatagaata agtgaaagaa aattggattt attgagcctc       60

aaaaatatga gtgaagcaca atcaaagaat gaatttcttt caagagaact aattgaaaaa      120

gaaagagatt tagaaaggag taggacagtg atagccaaat ttcagaataa attaaaagaa      180

ttagttgaag aaaataagca acttgaagaa ggtatgaaag aaatattgca agcaattaag      240

gaaatgcaga aagatcctga tgttaaagga ggagaaacat ctctaattat ccctagcctt      300

gaaagactag ttaatgctat agaatcaaag aatgcagaag gaatctttga tgcgagtctg      360

catttgaaag cccaagttga tcagcttacc ggaagaaatg aagaattaag acaggagctc      420

agggaatctc ggaaagaggc tataaattat tcacagcagt tggcaaaagc taatttaaag      480

atagaccatc ttgaaaaaga aactagtctt ttacgacaat cagaaggatc gaatgttgtt      540

tttaaaggaa ttgacttacc tgatgggata gcaccatcta gtgccagtat cattaattct      600

cagaatgaat atttaataca tttgttacag gaactagaaa ataaagaaaa aaagttaaag      660

aatttagaag attctcttga agattacaac agaaaatttg ctgtaattcg tcatcaacaa      720

agtttgttgt ataaagaata cctaagtgaa aaggagacct ggaaaacaga atctaaaaca      780

ataaaagagg aaaagagaaa acttgaggat caagtccaac aagatgctat aaaagtaaaa      840

gaatataata atttgctcaa tgctcttcag atggattcgg atgaaatgaa aaaaatactt      900

gcagaaaata gtaggaaaat tactgttttg caagtgaatg aaaaatcact tataaggcaa      960

tatacaacct tagtagaatt ggagcgacaa cttagaaaag aaaatgagaa gcaaaagaat     1020

gaattgttgt caatggaggc tgaagtttgt gaaaaaattg ggtgtttgca aagatttaag     1080

gaaatggcca ttttcaagat tgcagctctc caaaaagttg tagataatag tgtttctttg     1140

tctgaactag aactggctaa taaacagtac aatgaactga ctgctaagta cagggacatc     1200

ttgcaaaaag ataatatgct tgttcaaaga acaagtaact tggaacacct ggagtgtgaa     1260

aacatctcct taaaagaaca agtggagtct ataaataaag aactggagat taccaaggaa     1320

aaacttcaca ctattgaaca agcctgggaa caggaaacta aattaggtaa tgaatctagc     1380

atggataagg caaagaaatc aataaccaac agtgacattg tttccatttc aaaaaaaata     1440

actatgctgg aaatgaagga attaaatgaa aggcagcggg ctgaacattg tcaaaaaatg     1500

tatgaacact tacggacttc gttaaagcaa atggaggaac gtaattttga attggaaacc     1560

aaatttgctg agcttaccaa aatcaatttg gatgcacaga aggtggaaca gatgttaaga     1620

gatgaattag ctgatagtgt gagcaaggca gtaagtgatg ctgataggca acggattcta     1680

gaattagaga agaatgaaat ggaactaaaa gttgaagtgt caaaactgag agagatttct     1740

gatattgcca gaagacaagt tgaaattttg aatgcacaac aacaatctag ggacaaggaa     1800

gtaactgaaa acatttctca aggagataga ataagtgaaa gaaaattgga tttattgagc     1860

ctcaaaaata tgagtgaagc acaatcaaag aatgaatttc tttcaagaga actaattgaa     1920

aaagaaagag atttagaaag gagtaggaca gtgatagcca aatttcagaa taaattaaaa     1980

gaattagttg aagaaaataa gcaacttgaa gaaggtatga aagaaatatt gcaagcaatt     2040

aaggaaatgc agaaagatcc tgatgttaaa ggaggagaaa catctctaat tatccctagc     2100

cttgaaagac tagttaatgc tatagaatca aagaatgcag aaggaatctt tgatgcgagt     2160

ctgcatttga aagcccaagt tgatcagctt accggaagaa atgaagaatt aagacaggag     2220

ctcagggaat ctcggaaaga ggctataaat tattcacagc agttggcaaa agctaattta     2280

aagatagacc atcttgaaaa agaaactagt cttttacgac aatcagaagg atcgaatgtt     2340

gtttttaaag gaattgactt acctgatggg atagcaccat ctagtgccag tatcattaat     2400

tctcagaatg aatatttaat acatttgtta caggaactag aaaataaaga aaaaaagtta     2460

aagaatttag aagattctct tgaagattac aacagaaaat ttgctgtaat tcgtcatcaa     2520

caaagtttgt tgtataaaga atacctaagt gaaaaggaga cctggaaaac agaatctaaa     2580

acaataaaag aggaaaagag aaaacttgag gatcaagtcc aacaagatgc tataaaagta     2640

aaagaatata ataatttgct caatgctctt cagatggatt cggatgaaat gaaaaaaata     2700

cttgcagaaa atagtaggaa aattactgtt ttgcaagtga atgaaaaatc acttataagg     2760

caatatacaa ccttagtaga attggagcga caacttagaa aagaaaatga gaagcaaaag     2820

aatgaattgt tgtcaatgga ggctgaagtt tgtgaaaaaa ttgggtgttt gcaaagattt     2880

aaggaaatgg ccattttcaa gattgcagct ctccaaaaag ttgtagataa tagtgtttct     2940

ttgtctgaac tagaactggc taataaacag tacaatgaac tgactgctaa gtacagggac     3000

atcttgcaaa aagataatat gcttgttcaa agaacaagta acttggaaca cctggagtgt     3060

gaaaacatct ccttaaaaga acaagtggag tctataaata aagaactgga gattaccaag     3120

gaaaaacttc acactattga acaagcctgg gaacaggaaa ctaaattagg taatgaatct     3180

agcatggata aggcaaagaa atcaataacc aacagtgaca ttgtttccat ttcaaaaaaa     3240

ataactatgc tggaaatgaa ggaattaaat gaaaggcagc gggctgaaca ttgtcaaaaa     3300

atgtatgaac acttacggac ttcgttaaag caaatggagg aacgtaattt tgaattggaa     3360

accaaatttg ctgagcttac caaaatcaat ttggatgcac agaaggtgga acagatgtta     3420

agagatgaat tagctgatag tgtgagcaag gcagtaagtg atgctgatag gcaacggatt     3480

ctagaattag agaagaatga aatggaacta aaagttgaag tgtcaaaact gagagagatt     3540

tctgatattg ccagaagaca agttgaaatt ttgaatgcac aacaacaatc tagggacaag     3600

gaagta                                                                3606


<210>  6
<211>  1803
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
actgaaaaca tttctcaagg agatagaata agtgaaagaa aattggattt attgagcctc       60

aaaaatatga gtgaagcaca atcaaagaat gaatttcttt caagagaact aattgaaaaa      120

gaaagagatt tagaaaggag taggacagtg atagccaaat ttcagaataa attaaaagaa      180

ttagttgaag aaaataagca acttgaagaa ggtatgaaag aaatattgca agcaattaag      240

gaaatgcaga aagatcctga tgttaaagga ggagaaacat ctctaattat ccctagcctt      300

gaaagactag ttaatgctat agaatcaaag aatgcagaag gaatctttga tgcgagtctg      360

catttgaaag cccaagttga tcagcttacc ggaagaaatg aagaattaag acaggagctc      420

agggaatctc ggaaagaggc tataaattat tcacagcagt tggcaaaagc taatttaaag      480

atagaccatc ttgaaaaaga aactagtctt ttacgacaat cagaaggatc gaatgttgtt      540

tttaaaggaa ttgacttacc tgatgggata gcaccatcta gtgccagtat cattaattct      600

cagaatgaat atttaataca tttgttacag gaactagaaa ataaagaaaa aaagttaaag      660

aatttagaag attctcttga agattacaac agaaaatttg ctgtaattcg tcatcaacaa      720

agtttgttgt ataaagaata cctaagtgaa aaggagacct ggaaaacaga atctaaaaca      780

ataaaagagg aaaagagaaa acttgaggat caagtccaac aagatgctat aaaagtaaaa      840

gaatataata atttgctcaa tgctcttcag atggattcgg atgaaatgaa aaaaatactt      900

gcagaaaata gtaggaaaat tactgttttg caagtgaatg aaaaatcact tataaggcaa      960

tatacaacct tagtagaatt ggagcgacaa cttagaaaag aaaatgagaa gcaaaagaat     1020

gaattgttgt caatggaggc tgaagtttgt gaaaaaattg ggtgtttgca aagatttaag     1080

gaaatggcca ttttcaagat tgcagctctc caaaaagttg tagataatag tgtttctttg     1140

tctgaactag aactggctaa taaacagtac aatgaactga ctgctaagta cagggacatc     1200

ttgcaaaaag ataatatgct tgttcaaaga acaagtaact tggaacacct ggagtgtgaa     1260

aacatctcct taaaagaaca agtggagtct ataaataaag aactggagat taccaaggaa     1320

aaacttcaca ctattgaaca agcctgggaa caggaaacta aattaggtaa tgaatctagc     1380

atggataagg caaagaaatc aataaccaac agtgacattg tttccatttc aaaaaaaata     1440

actatgctgg aaatgaagga attaaatgaa aggcagcggg ctgaacattg tcaaaaaatg     1500

tatgaacact tacggacttc gttaaagcaa atggaggaac gtaattttga attggaaacc     1560

aaatttgctg agcttaccaa aatcaatttg gatgcacaga aggtggaaca gatgttaaga     1620

gatgaattag ctgatagtgt gagcaaggca gtaagtgatg ctgataggca acggattcta     1680

gaattagaga agaatgaaat ggaactaaaa gttgaagtgt caaaactgag agagatttct     1740

gatattgcca gaagacaagt tgaaattttg aatgcacaac aacaatctag ggacaaggaa     1800

gta                                                                   1803


<210>  7
<211>  1545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
gagtccctca gaatgcaact gctagactat caggcacagt ctgatgaaaa gtcgctcatt       60

gccaagttgc accaacataa tgtctctctt caactgagtg aggctactgc tcttggtaag      120

ttggagtcaa ttacatctaa actgcagaag atggaggcct acaacttgcg cttagagcag      180

aaacttgatg aaaaagaaca ggctctctat tatgctcgtt tggagggaag aaacagagca      240

aaacatctgc gccaaacaat tcagtctcta cgacgacagt ttagtggagc tttacccttg      300

gcacaacagg aaaagttctc caaaacaatg attcaactac aaaatgacaa acttaagata      360

atgcaagaaa tgaaaaattc tcaacaagaa catagaaata tggagaacaa aacattggag      420

atggaattaa aattaaaggg cctggaagag ttaataagca ctttaaagga taccaaagga      480

gcccaaaagg taatcaactg gcatatgaaa atagaagaac ttcgtcttca agaacttaaa      540

ctaaatcggg aattagtcaa ggataaagaa gaaataaaat atttgaataa cataatttct      600

gaatatgaac gtacaatcag cagtcttgaa gaagaaattg tgcaacagaa caagtttcat      660

gaagaaagac aaatggcctg ggatcaaaga gaagttgacc tggaacgcca actagacatt      720

tttgaccgtc agcaaaatga aatactaaat gcggcacaaa agtttgaaga agctacagga      780

tcaatccctg accctagttt gccccttcca aatcaacttg agatcgctct aaggaaaatt      840

aaggagaaca ttcgaataat tctagaaaca cgggcaactt gcaaatcact agaagagaaa      900

ctaaaagaga aagaatctgc tttaaggtta gcagaacaaa atatactgtc aagagacaaa      960

gtaatcaatg aactgaggct tcgattgcct gccactgcag aaagagaaaa gctcatagct     1020

gagctaggca gaaaagagat ggaaccaaaa tctcaccaca cattgaaaat tgctcatcaa     1080

accattgcaa acatgcaagc aaggttaaat caaaaagaag aagtattaaa gaagtatcaa     1140

cgtcttctag aaaaagccag agaggagcaa agagaaattg tgaagaaaca tgaggaagac     1200

cttcatattc ttcatcacag attagaacta caggctgata gttcactaaa taaattcaaa     1260

caaacggctt gggatttaat gaaacagtct cccactccag ttcctaccaa caagcatttt     1320

attcgtctgg ctgagatgga acagacagta gcagaacaag atgactctct ttcctcactc     1380

ttggtcaaac taaagaaagt atcacaagat ttggagagac aaagagaaat cactgaatta     1440

aaagtaaaag aatttgaaaa tatcaaatta cagcttcaag aaaaccatga agatgaagtg     1500

aaaaaagtaa aagcggaagt agaggattta aagtatcttc tggac                     1545


<210>  8
<211>  7972
<212>  DNA
<213>  Homo sapiens

<400>  8
atttgaagtc ctcgttccac gccttctcat catcctgaac accgagctct gggactccgg       60

cggagaatct aaacgtaaag catcacccac ggtcgtgaac tgtaggctct cctggcatcc      120

gggatcttat tctggccttg gcggagttgg ggatggtgtc gcctagcagc cgctgccgct      180

ttggcttgct cgggaccatt tggctggacc cagagtccgc gtggaaccgc gatagggatc      240

tgtcagggcc cgcggccggg tccagcttgg tggttgcggt agtgagaggc ctccgctggt      300

tgccaggctt ggtctagagg tggagcacag tgaaagaatt caagatgcca cctaatataa      360

actggaaaga aataatgaaa gttgacccag atgacctgcc ccgtcaagaa gaactggcag      420

ataatttatt gatttcctta tccaaggtgg aagtaaatga gctaaaaagt gaaaagcaag      480

aaaatgtgat acaccttttc agaattactc agtcactaat gaagatgaaa gctcaagaag      540

tggagctggc tttggaagaa gtagaaaaag ctggagaaga acaagcaaaa tttgaaaatc      600

aattaaaaac taaagtaatg aaactggaaa atgaactgga gatggctcag cagtctgcag      660

gtggacgaga tactcggttt ttacgtaatg aaatttgcca acttgaaaaa caattagaac      720

aaaaagatag agaattggag gacatggaaa aggagttgga gaaagagaag aaagttaatg      780

agcaattggc tcttcgaaat gaggaggcag aaaatgaaaa cagcaaatta agaagagaga      840

acaaacgtct aaagaaaaag aatgaacaac tttgtcagga tattattgac taccagaaac      900

aaatagattc acagaaagaa acacttttat caagaagagg ggaagacagt gactaccgat      960

cacagttgtc taaaaaaaac tatgagctta tccaatatct tgatgaaatt cagactttaa     1020

cagaagctaa tgagaaaatt gaagttcaga atcaagaaat gagaaaaaat ttagaagagt     1080

ctgtacagga aatggagaag atgactgatg aatataatag aatgaaagct attgtgcatc     1140

agacagataa tgtaatagat cagttaaaaa aagaaaacga tcattatcaa cttcaagtgc     1200

aggagcttac agatcttctg aaatcaaaaa atgaagaaga tgatccaatt atggtagctg     1260

tcaatgcaaa agtagaagaa tggaagctaa ttttgtcttc taaagatgat gaaattattg     1320

agtatcagca aatgttacat aacctaaggg agaaacttaa gaatgctcag cttgatgctg     1380

ataaaagtaa tgttatggct ctacagcagg gtatacagga acgagacagt caaattaaga     1440

tgctcaccga acaagtagaa caatatacaa aagaaatgga aaagaatact tgtattattg     1500

aagatttgaa aaatgagctc caaagaaaca aaggtgcttc aaccctttct caacagactc     1560

atatgaaaat tcagtcaacg ttagacattt taaaagagaa aactaaagag gctgagagaa     1620

cagctgaact ggctgaggct gatgctaggg aaaaggataa agaattagtt gaggctctga     1680

agaggttaaa agattatgaa tcgggagtat atggtttaga agatgctgtc gttgaaataa     1740

agaattgtaa aaaccaaatt aaaataagag atcgagagat tgaaatatta acaaaggaaa     1800

tcaataaact tgaattgaag atcagtgatt tccttgatga aaatgaggca cttagagagc     1860

gtgtgggcct tgaaccaaag acaatgattg atttaactga atttagaaat agcaaacact     1920

taaaacagca gcagtacaga gctgaaaacc agattctttt gaaagagatt gaaagtctag     1980

aggaagaacg acttgatctg aaaaaaaaaa ttcgtcaaat ggctcaagaa agaggaaaaa     2040

gaagtgcaac ttcaggatta accactgagg acctgaacct aactgaaaac atttctcaag     2100

gagatagaat aagtgaaaga aaattggatt tattgagcct caaaaatatg agtgaagcac     2160

aatcaaagaa tgaatttctt tcaagagaac taattgaaaa agaaagagat ttagaaagga     2220

gtaggacagt gatagccaaa tttcagaata aattaaaaga attagttgaa gaaaataagc     2280

aacttgaaga aggtatgaaa gaaatattgc aagcaattaa ggaaatgcag aaagatcctg     2340

atgttaaagg aggagaaaca tctctaatta tccctagcct tgaaagacta gttaatgcta     2400

tagaatcaaa gaatgcagaa ggaatctttg atgcgagtct gcatttgaaa gcccaagttg     2460

atcagcttac cggaagaaat gaagaattaa gacaggagct cagggaatct cggaaagagg     2520

ctataaatta ttcacagcag ttggcaaaag ctaatttaaa gatagaccat cttgaaaaag     2580

aaactagtct tttacgacaa tcagaaggat cgaatgttgt ttttaaagga attgacttac     2640

ctgatgggat agcaccatct agtgccagta tcattaattc tcagaatgaa tatttaatac     2700

atttgttaca ggaactagaa aataaagaaa aaaagttaaa gaatttagaa gattctcttg     2760

aagattacaa cagaaaattt gctgtaattc gtcatcaaca aagtttgttg tataaagaat     2820

acctaagtga aaaggagacc tggaaaacag aatctaaaac aataaaagag gaaaagagaa     2880

aacttgagga tcaagtccaa caagatgcta taaaagtaaa agaatataat aatttgctca     2940

atgctcttca gatggattcg gatgaaatga aaaaaatact tgcagaaaat agtaggaaaa     3000

ttactgtttt gcaagtgaat gaaaaatcac ttataaggca atatacaacc ttagtagaat     3060

tggagcgaca acttagaaaa gaaaatgaga agcaaaagaa tgaattgttg tcaatggagg     3120

ctgaagtttg tgaaaaaatt gggtgtttgc aaagatttaa ggaaatggcc attttcaaga     3180

ttgcagctct ccaaaaagtt gtagataata gtgtttcttt gtctgaacta gaactggcta     3240

ataaacagta caatgaactg actgctaagt acagggacat cttgcaaaaa gataatatgc     3300

ttgttcaaag aacaagtaac ttggaacacc tggagtgtga aaacatctcc ttaaaagaac     3360

aagtggagtc tataaataaa gaactggaga ttaccaagga aaaacttcac actattgaac     3420

aagcctggga acaggaaact aaattaggta atgaatctag catggataag gcaaagaaat     3480

caataaccaa cagtgacatt gtttccattt caaaaaaaat aactatgctg gaaatgaagg     3540

aattaaatga aaggcagcgg gctgaacatt gtcaaaaaat gtatgaacac ttacggactt     3600

cgttaaagca aatggaggaa cgtaattttg aattggaaac caaatttgct gagcttacca     3660

aaatcaattt ggatgcacag aaggtggaac agatgttaag agatgaatta gctgatagtg     3720

tgagcaaggc agtaagtgat gctgataggc aacggattct agaattagag aagaatgaaa     3780

tggaactaaa agttgaagtg tcaaaactga gagagatttc tgatattgcc agaagacaag     3840

ttgaaatttt gaatgcacaa caacaatcta gggacaagga agtagagtcc ctcagaatgc     3900

aactgctaga ctatcaggca cagtctgatg aaaagtcgct cattgccaag ttgcaccaac     3960

ataatgtctc tcttcaactg agtgaggcta ctgctcttgg taagttggag tcaattacat     4020

ctaaactgca gaagatggag gcctacaact tgcgcttaga gcagaaactt gatgaaaaag     4080

aacaggctct ctattatgct cgtttggagg gaagaaacag agcaaaacat ctgcgccaaa     4140

caattcagtc tctacgacga cagtttagtg gagctttacc cttggcacaa caggaaaagt     4200

tctccaaaac aatgattcaa ctacaaaatg acaaacttaa gataatgcaa gaaatgaaaa     4260

attctcaaca agaacataga aatatggaga acaaaacatt ggagatggaa ttaaaattaa     4320

agggcctgga agagttaata agcactttaa aggataccaa aggagcccaa aaggtaatca     4380

actggcatat gaaaatagaa gaacttcgtc ttcaagaact taaactaaat cgggaattag     4440

tcaaggataa agaagaaata aaatatttga ataacataat ttctgaatat gaacgtacaa     4500

tcagcagtct tgaagaagaa attgtgcaac agaacaagtt tcatgaagaa agacaaatgg     4560

cctgggatca aagagaagtt gacctggaac gccaactaga catttttgac cgtcagcaaa     4620

atgaaatact aaatgcggca caaaagtttg aagaagctac aggatcaatc cctgacccta     4680

gtttgcccct tccaaatcaa cttgagatcg ctctaaggaa aattaaggag aacattcgaa     4740

taattctaga aacacgggca acttgcaaat cactagaaga gaaactaaaa gagaaagaat     4800

ctgctttaag gttagcagaa caaaatatac tgtcaagaga caaagtaatc aatgaactga     4860

ggcttcgatt gcctgccact gcagaaagag aaaagctcat agctgagcta ggcagaaaag     4920

agatggaacc aaaatctcac cacacattga aaattgctca tcaaaccatt gcaaacatgc     4980

aagcaaggtt aaatcaaaaa gaagaagtat taaagaagta tcaacgtctt ctagaaaaag     5040

ccagagagga gcaaagagaa attgtgaaga aacatgagga agaccttcat attcttcatc     5100

acagattaga actacaggct gatagttcac taaataaatt caaacaaacg gcttgggatt     5160

taatgaaaca gtctcccact ccagttccta ccaacaagca ttttattcgt ctggctgaga     5220

tggaacagac agtagcagaa caagatgact ctctttcctc actcttggtc aaactaaaga     5280

aagtatcaca agatttggag agacaaagag aaatcactga attaaaagta aaagaatttg     5340

aaaatatcaa attacagctt caagaaaacc atgaagatga agtgaaaaaa gtaaaagcgg     5400

aagtagagga tttaaagtat cttctggacc agtcacaaaa ggagtcacag tgtttaaaat     5460

ctgaacttca ggctcaaaaa gaagcaaatt caagagctcc aacaactaca atgagaaatc     5520

tagtagaacg gctaaagagc caattagcct tgaaggagaa acaacagaaa gcacttagtc     5580

gggcactttt agaactccgg gcagaaatga cagcagctgc tgaagaacgt attatttctg     5640

caacttctca aaaagaggcc catctcaatg ttcaacaaat cgttgatcga catactagag     5700

agctaaagac acaagttgaa gatttaaatg aaaatctttt aaaattgaaa gaagcactta     5760

aaacaagtaa aaacagagaa aactcactaa ctgataattt gaatgactta aataatgaac     5820

tgcaaaagaa acaaaaagcc tataataaaa tacttagaga gaaagaggaa attgatcaag     5880

agaatgatga actgaaaagg caaattaaaa gactaaccag tggattacag ggcaaacccc     5940

tgacagataa taaacaaagt ctaattgaag aactccaaag gaaagttaaa aaactagaga     6000

accaattaga gggaaaggtg gaggaagtag acctaaaacc tatgaaagaa aagaatgcta     6060

aagaagaatt aattaggtgg gaagaaggta aaaagtggca agccaaaata gaaggaattc     6120

gaaacaagtt aaaagagaaa gagggggaag tctttacttt aacaaagcag ttgaatactt     6180

tgaaggatct ttttgccaaa gccgataaag agaaacttac tttgcagagg aaactaaaaa     6240

caactggcat gactgttgat caggttttgg gaatacgagc tttggagtca gaaaaagaat     6300

tggaagaatt aaaaaagaga aatcttgact tagaaaatga tatattgtat atgagggccc     6360

accaagctct tcctcgagat tctgttgtag aagatttaca tttacaaaat agatacctcc     6420

aagaaaaact tcatgcttta gaaaaacagt tttcaaagga tacatattct aagccttcaa     6480

tttcaggaat agagtcagat gatcattgtc agagagaaca ggagcttcag aaggaaaact     6540

tgaagttgtc atctgaaaat attgaactga aatttcagct tgaacaagca aataaagatt     6600

tgccaagatt aaagaatcaa gtcagagatt tgaaggaaat gtgtgaattt cttaagaaag     6660

aaaaagcaga agttcagcgg aaacttggcc atgttagagg gtctggtaga agtggaaaga     6720

caatcccaga actggaaaaa accattggtt taatgaaaaa agtagttgaa aaagtccaga     6780

gagaaaatga acagttgaaa aaagcatcag gaatattgac tagtgaaaaa atggctaata     6840

ttgagcagga aaatgaaaaa ttgaaggctg aattagaaaa acttaaagct catcttgggc     6900

atcagttgag catgcactat gaatccaaga ccaaaggcac agaaaaaatt attgctgaaa     6960

atgaaaggct tcgtaaagaa cttaaaaaag aaactgatgc tgcagagaaa ttacggatag     7020

caaagaataa tttagagata ttaaatgaga agatgacagt tcaactagaa gagactggta     7080

agagattgca gtttgcagaa agcagaggtc cacagcttga aggtgctgac agtaagagct     7140

ggaaatccat tgtggttaca agaatgtatg aaaccaagtt aaaagaattg gaaactgata     7200

ttgccaaaaa aaatcaaagc attactgacc ttaaacagct tgtaaaagaa gcaacagaga     7260

gagaacaaaa agttaacaaa tacaatgaag accttgaaca acagattaag attcttaaac     7320

atgttcctga aggtgctgag acagagcaag gccttaaacg ggagcttcaa gttcttagat     7380

tagctaatca tcagctggat aaagagaaag cagaattaat ccatcagata gaagctaaca     7440

aggaccaaag tggagctgaa agcaccatac ctgatgctga tcaactaaag gaaaaaataa     7500

aagatctaga gacacagctc aaaatgtcag atctagaaaa gcagcatttg aaggaggaaa     7560

taaagaagct gaaaaaagaa ctggaaaatt ttgatccttc attttttgaa gaaattgaag     7620

atcttaagta taattacaag gaagaagtga agaagaatat tctcttagaa gagaaggtaa     7680

aaaaactttc agaacaattg ggagttgaat taactagccc tgttgctgct tctgaagagt     7740

ttgaagatga agaagaaagt cctgttaatt tccccattta ctaaaggtca cctataaact     7800

ttgtttcatt taactattta ttaactttat aagttaaata tacttggaaa taagcagttc     7860

tccgaactgt agtatttcct tctcactacc ttgtaccttt atacttagat tggaattctt     7920

aataaataaa attatatgaa attttcaact tattaaaaaa aaaaaaaaaa aa             7972


<210>  9
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


