                         SEQUENCE LISTING

<110>  ASTUTE MEDICAL, INC.
 
<120>  ASSAYS FOR TIMP2 HAVING IMPROVED PERFORMANCE IN BIOLOGICAL 
       SAMPLES

<130>  AST(M)-005-PCT

<140>  PCT/US2018/026058
<141>  2018-04-04

<150>  US 62/482,089
<151>  2017-04-05

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Glu Ser Ile Ser Gly Trp 
1               5       


<210>  2
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Arg Ala Ser 
1           


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Gln Cys Ser Tyr Gly Ile Asn Gly Asn Ser Glu His Gly Asn Pro 
1               5                   10                  15  


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gly Phe Thr Ile Ser Ser Asn Tyr Tyr 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Ile Leu Gly Gly Ser Gly Thr Tyr Thr 
1               5                   


<210>  6
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ala Arg Gln Ala Pro Ala Asp Thr Tyr Leu Tyr Gly Gly Tyr Gly Pro 
1               5                   10                  15      


Phe Asn Leu 
            


<210>  7
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Ser Tyr Gly Ile Asn Gly 
                85                  90                  95      


Asn Ser Glu His Gly Asn Pro Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys 
    


<210>  8
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Glu Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Asn Tyr 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Cys Ile Leu Gly Gly Ser Gly Thr Tyr Thr Tyr Tyr Ala Thr Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Pro Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Ala Pro Ala Asp Thr Tyr Leu Tyr Gly Gly Tyr Gly Pro 
            100                 105                 110         


Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  9
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcgttggagg agtccggggg agacctggtc aagcctgagg gatccctgac actcacctgc      120

acagcctctg gattcaccat cagttctaac tactacatgt gctgggtccg ccaggctcca      180

gggaaggggc tggagtgggt cgcatgcatt ttgggtggta gtggtactta cacttactac      240

gcgacctggg cgaaaggccg attcaccatc tccaaaacct cgtcgaccac ggtgactctg      300

caaatgccca gtctgacagc cgcggacacg gccacctatt tctgtgcgag acaggcccct      360

gccgatactt atctttatgg tggttatggt ccctttaact tgtggggcca agggaccctc      420

gtcaccgtct cgagcggaca gccgaaagcc ccgtcggtgt ttccactggc gccctgctgt      480

ggcgatacgc cttcgtccac cgtgaccctt ggctgtcttg tgaagggtta ccttcccgag      540

ccggtcactg taacatggaa ttcagggaca ctcacgaacg gggtcaggac tttcccatca      600

gtcagacagt catccggtct gtattcactt agctcggtag tgtccgtaac ttcctccagc      660

cagccggtaa catgtaacgt agcgcacccc gccaccaata ccaaggtgga caagaccgtg      720

gccccctcaa catgctcgaa acctacgtgc cctccgcctg aacttctcgg gggtcccagc      780

gtctttatct tccctcctaa gcccaaagat acgctgatga tctcgcggac cccggaggtg      840

acttgtgtcg tggtcgatgt ctcccaagac gatcccgaag tacagttcac ctggtacatt      900

aacaacgagc aagtccgaac ggccaggcca ccgttgcgcg agcagcaatt caattcgacg      960

atccgggtgg tatcaacgtt gccgatcact catcaggact ggttgcaagg gaaggaattc     1020

aaatgcaagg tccacaacaa ggcccttccg gcaccaatcg agaaaacgat cagcaaggcg     1080

agggggcagc ccctggaacc caaggtctat acaatgggac cacccaggga agagttgtca     1140

tcccggtccg tatcgcttac atgcatgatt aacggtttct atccttcaga catttcagta     1200

gagtgggaga agaatggaaa agccgaagat aactacaaaa caacccccgc agtacttgac     1260

tccgacggat cgtacttctt gtacaacaag ctctcggtgc ccacgtcaga atggcaacga     1320

ggggatgtct ttacatgctc ggtgatgcat gaggcactcc acaatcatta cacgcagaaa     1380

agcatctccc gctcgccggg aaagtgatag                                      1410


<210>  10
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro 
            20                  25                  30          


Glu Gly Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser 
        35                  40                  45              


Ser Asn Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Cys Ile Leu Gly Gly Ser Gly Thr Tyr Thr Tyr Tyr 
65                  70                  75                  80  


Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr 
                85                  90                  95      


Thr Val Thr Leu Gln Met Pro Ser Leu Thr Ala Ala Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gln Ala Pro Ala Asp Thr Tyr Leu Tyr Gly Gly 
        115                 120                 125             


Tyr Gly Pro Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys 
145                 150                 155                 160 


Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly 
                165                 170                 175     


Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr 
            180                 185                 190         


Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr 
    210                 215                 220                 


Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val 
225                 230                 235                 240 


Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln 
    290                 295                 300                 


Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Ile Arg Val Val Ser Thr Leu Pro Ile Thr His Gln Asp Trp Leu Gln 
                325                 330                 335     


Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys 
        355                 360                 365             


Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val 
    370                 375                 380                 


Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val 
385                 390                 395                 400 


Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser 
            420                 425                 430         


Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  11
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Glu Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser 
            20                  


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Cys 
    


<210>  13
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Tyr Tyr Ala Thr Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser 
1               5                   10                  15      


Ser Thr Thr Val Thr Leu Gln Met Pro Ser Leu Thr Ala Ala Asp Thr 
            20                  25                  30          


Ala Thr Tyr Phe Cys 
        35          


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

agatgtgccg acatcgtgat gacccagact ccatcctccg tggaggcagc tgtgggaggc      120

acagtcacca tcaagtgcca ggccagtgag agcattagcg gttggttggc ctggtatcag      180

cagaaaccag ggcagcctcc caagctcctg atctacaggg catccactct ggaatctggg      240

gtcccatcgc ggttcaaagg cagtggatct gggacagagt tcactctcac catcagcgac      300

ctggagtgtg ccgatgctgc cacttattat tgtcaatgca gttatggtat taatggtaat      360

agtgagcatg gtaatccttt cggcggaggg accgaggtgg tggtcaaacg tacgcccgtg      420

gcacccactg tactcctgtt tccgccttcc tcggatgagg tggcgacggg cacggtcaca      480

atcgtctgcg tggcgaataa gtactttccg gatgtcacag tgacgtggga ggtggacggg      540

acaacacaga ccacaggtat tgaaaacagc aaaacaccgc agaattcggc tgactgtacg      600

tataacttgt cctccactct tacgttgaca tcaacacagt acaattcgca caaggagtat      660

acgtgcaagg taacccaggg tacgacaagc gtagtccagt ccttcagcag gaagaactgc      720

tgataa                                                                 726


<210>  16
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Asp Ile Val Met Thr Gln Thr Pro Ser 
            20                  25                  30          


Ser Val Glu Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
        35                  40                  45              


Ser Glu Ser Ile Ser Gly Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Cys Ser Tyr Gly Ile Asn Gly Asn Ser Glu His Gly Asn Pro Phe Gly 
        115                 120                 125             


Gly Gly Thr Glu Val Val Val Lys Arg Thr Pro Val Ala Pro Thr Val 
    130                 135                 140                 


Leu Leu Phe Pro Pro Ser Ser Asp Glu Val Ala Thr Gly Thr Val Thr 
145                 150                 155                 160 


Ile Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp 
                165                 170                 175     


Glu Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr 
            180                 185                 190         


Pro Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr 
        195                 200                 205             


Leu Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val 
    210                 215                 220                 


Thr Gln Gly Thr Thr Ser Val Val Gln Ser Phe Ser Arg Lys Asn Cys 
225                 230                 235                 240 


<210>  17
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser 
            20                  25      


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  19
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Asn His Arg Tyr Gln Met Gly Cys Glu Cys Lys Ile 
1               5                   10          


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

His Pro Gln Gln Ala Phe Cys Asn Ala 
1               5                   


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Arg Ser Asp Gly Ser Cys Ala Trp Tyr Arg 
1               5                   10  


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Asp His Ile Asn Asn Trp 
1               5       


<210>  25
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Ser Gly Ala 
1           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Gln Gln Tyr Trp Ser Thr Pro Phe Thr 
1               5                   


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Ile Asp Pro Ser Asp Ser Glu Thr 
1               5               


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Ala Arg Arg Asp Tyr Gly Ser Arg Tyr Asp Ala Met Asp Tyr 
1               5                   10                  


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  31
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Gly Ser Arg Tyr Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  32
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
atgggctgga gctgcattat tctgtttctg gtgagcaccg cgaccggcgt gcatagccag       60

gtgcagctgc agcagagcgg cccgcagctg gtgcgcccgg gcgcgagcgt gaaaattagc      120

tgcaaagcga gcggctatag ctttaccagc tattggatgc attgggtgaa acagcgcccg      180

ggccagggcc tggaatggat tggcgtgatt gatccgagcg atagcgaaac ccgcctgaac      240

cagaaattta aagataaagc gaccctgacc gtggataaaa gcagcagcac cgcgtatatg      300

cagctgaaca gcccgaccag cgaagatagc gcggtgtatt attgcgcgcg ccgcgattat      360

ggcagccgct atgatgcgat ggattattgg ggccagggca ccagcgtgac cgtgagcagc      420

gcgaaaacca ccccgccgag cgtgtatccg ctggcgccgg gcagcgcggc gcagaccaac      480

agcatggtga ccctgggctg cctggtgaaa ggctattttc cggaaccggt gaccgtgacc      540

tggaac                                                                 546


<210>  33
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ser Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Asn Ser Pro Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Arg Asp Tyr Gly Ser Arg Tyr Asp Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn 
            180         


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala Ser Val Lys Ile Ser 
1               5                   10                  15      


Cys Lys Ala Ser 
            20  


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Val 
    


<210>  36
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Arg Leu Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Pro Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  38
<211>  441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
atgaaatttc cgagccagct gctgctgttt ctgctgtttc gcattaccgg cattatttgc       60

gatattcaga tgacccagag cagcagctat ctgagcgtga gcctgggcgg ccgcgtgacc      120

attacctgca aagcgagcga tcatattaac aactggctgg cgtggtatca gcagaaaccg      180

ggcaacgcgc cgcgcctgct gattagcggc gcgaccagcc tggaaaccgg cgtgccgagc      240

cgctttagcg gcagcggcag cggcaaagat tataccctga gcattaccag cctgcagacc      300

gaagatgtgg cgacctatta ttgccagcag tattggagca ccccgtttac ctttggcagc      360

ggcaccaaac tggaaattaa acgcgcggat gcggcgccga ccgtgagcat ttttccgccg      420

agcagcgaac agctgagcaa c                                                441


<210>  39
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Met Lys Phe Pro Ser Gln Leu Leu Leu Phe Leu Leu Phe Arg Ile Thr 
1               5                   10                  15      


Gly Ile Ile Cys Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser 
            20                  25                  30          


Val Ser Leu Gly Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His 
        35                  40                  45              


Ile Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr 
                85                  90                  95      


Ser Leu Gln Thr Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp 
            100                 105                 110         


Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Ser Asn 
145         


<210>  40
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
1               5                   10                  15      


<210>  42
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Val 
            20                  25                  30          


Ala Thr Tyr Tyr Cys 
        35          


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Pro Trp Asp Thr Leu Ser Thr Thr Gln Lys Lys 
1               5                   10      


<210>  45
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Cys Ser Cys Ser Pro Val 
            20                  25                  30          


His Pro Gln Gln Ala Phe Cys Asn Ala Asp Val Val Ile Arg Ala Lys 
        35                  40                  45              


Ala Val Ser Glu Lys Glu Val Asp Ser Gly Asn Asp Ile Tyr Gly Asn 
    50                  55                  60                  


Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys Gln Ile Lys Met Phe Lys 
65                  70                  75                  80  


Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr Thr Ala Pro Ser Ser Ala 
                85                  90                  95      


Val Cys Gly Val Ser Leu Asp Val Gly Gly Lys Lys Glu Tyr Leu Ile 
            100                 105                 110         


Ala Gly Lys Ala Glu Gly Asp Gly Lys Met His Ile Thr Leu Cys Asp 
        115                 120                 125             


Phe Ile Val Pro Trp Asp Thr Leu Ser Thr Thr Gln Lys Lys Ser Leu 
    130                 135                 140                 


Asn His Arg Tyr Gln Met Gly Cys Glu Cys Lys Ile Thr Arg Cys Pro 
145                 150                 155                 160 


Met Ile Pro Cys Tyr Ile Ser Ser Pro Asp Glu Cys Leu Trp Met Asp 
                165                 170                 175     


Trp Val Thr Glu Lys Asn Ile Asn Gly His Gln Ala Lys Phe Phe Ala 
            180                 185                 190         


Cys Ile Lys Arg Ser Asp Gly Ser Cys Ala Trp Tyr Arg Gly Ala Ala 
        195                 200                 205             


Pro Pro Lys Gln Glu Phe Leu Asp Ile Glu Asp Pro 
    210                 215                 220 


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu Leu 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Gly Ala Gly Leu Leu 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Ala Ala Leu Leu Leu 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Ala Ala Leu Leu Leu 
1               5                   10                  15  


