                         SEQUENCE LISTING

<110>  University of Washington
       Institute for Research in Biomedicine
       KING, Neil P
       BAKER, David
       NICKERSON, Brooke
       STEWART, Lance J
       PEREZ, Laurent
       LANZAVECCHIA, Antonio
       MARCANDALLI, Jessica
 
<120>  Self-assembling protein nanostructures displaying paramyxovirus 
       and/or pneumovirus F proteins and their use

<130>  17-341-PCT

<150>  US 62/481,331
<151>  2017-04-01

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-34A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  1

Met Glu Gly Met Asp Pro Leu Ala Val Leu Ala Glu Ser Arg Leu Leu 
1               5                   10                  15      


Pro Leu Leu Thr Val Arg Gly Gly Glu Asp Leu Ala Gly Leu Ala Thr 
            20                  25                  30          


Val Leu Glu Leu Met Gly Val Gly Ala Leu Glu Ile Thr Leu Arg Thr 
        35                  40                  45              


Glu Lys Gly Leu Glu Ala Leu Lys Ala Leu Arg Lys Ser Gly Leu Leu 
    50                  55                  60                  


Leu Gly Ala Gly Thr Val Arg Ser Pro Lys Glu Ala Glu Ala Ala Leu 
65                  70                  75                  80  


Glu Ala Gly Ala Ala Phe Leu Val Ser Pro Gly Leu Leu Glu Glu Val 
                85                  90                  95      


Ala Ala Leu Ala Gln Ala Arg Gly Val Pro Tyr Leu Pro Gly Val Leu 
            100                 105                 110         


Thr Pro Thr Glu Val Glu Arg Ala Leu Ala Leu Gly Leu Ser Ala Leu 
        115                 120                 125             


Lys Phe Phe Pro Ala Glu Pro Phe Gln Gly Val Arg Val Leu Arg Ala 
    130                 135                 140                 


Tyr Ala Glu Val Phe Pro Glu Val Arg Phe Leu Pro Thr Gly Gly Ile 
145                 150                 155                 160 


Lys Glu Glu His Leu Pro His Tyr Ala Ala Leu Pro Asn Leu Leu Ala 
                165                 170                 175     


Val Gly Gly Ser Trp Leu Leu Gln Gly Asp Leu Ala Ala Val Met Lys 
            180                 185                 190         


Lys Val Lys Ala Ala Lys Ala Leu Leu Ser Pro Gln Ala Pro Gly 
        195                 200                 205         


<210>  2
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-34B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  2

Met Thr Lys Lys Val Gly Ile Val Asp Thr Thr Phe Ala Arg Val Asp 
1               5                   10                  15      


Met Ala Glu Ala Ala Ile Arg Thr Leu Lys Ala Leu Ser Pro Asn Ile 
            20                  25                  30          


Lys Ile Ile Arg Lys Thr Val Pro Gly Ile Lys Asp Leu Pro Val Ala 
        35                  40                  45              


Cys Lys Lys Leu Leu Glu Glu Glu Gly Cys Asp Ile Val Met Ala Leu 
    50                  55                  60                  


Gly Met Pro Gly Lys Ala Glu Lys Asp Lys Val Cys Ala His Glu Ala 
65                  70                  75                  80  


Ser Leu Gly Leu Met Leu Ala Gln Leu Met Thr Asn Lys His Ile Ile 
                85                  90                  95      


Glu Val Phe Val His Glu Asp Glu Ala Lys Asp Asp Asp Glu Leu Asp 
            100                 105                 110         


Ile Leu Ala Leu Val Arg Ala Ile Glu His Ala Ala Asn Val Tyr Tyr 
        115                 120                 125             


Leu Leu Phe Lys Pro Glu Tyr Leu Thr Arg Met Ala Gly Lys Gly Leu 
    130                 135                 140                 


Arg Gln Gly Arg Glu Asp Ala Gly Pro Ala Arg Glu 
145                 150                 155     


<210>  3
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-40A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  3

Met Thr Lys Lys Val Gly Ile Val Asp Thr Thr Phe Ala Arg Val Asp 
1               5                   10                  15      


Met Ala Ser Ala Ala Ile Leu Thr Leu Lys Met Glu Ser Pro Asn Ile 
            20                  25                  30          


Lys Ile Ile Arg Lys Thr Val Pro Gly Ile Lys Asp Leu Pro Val Ala 
        35                  40                  45              


Cys Lys Lys Leu Leu Glu Glu Glu Gly Cys Asp Ile Val Met Ala Leu 
    50                  55                  60                  


Gly Met Pro Gly Lys Ala Glu Lys Asp Lys Val Cys Ala His Glu Ala 
65                  70                  75                  80  


Ser Leu Gly Leu Met Leu Ala Gln Leu Met Thr Asn Lys His Ile Ile 
                85                  90                  95      


Glu Val Phe Val His Glu Asp Glu Ala Lys Asp Asp Ala Glu Leu Lys 
            100                 105                 110         


Ile Leu Ala Ala Arg Arg Ala Ile Glu His Ala Leu Asn Val Tyr Tyr 
        115                 120                 125             


Leu Leu Phe Lys Pro Glu Tyr Leu Thr Arg Met Ala Gly Lys Gly Leu 
    130                 135                 140                 


Arg Gln Gly Phe Glu Asp Ala Gly Pro Ala Arg Glu 
145                 150                 155     


<210>  4
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-40B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  4

Met Ser Thr Ile Asn Asn Gln Leu Lys Ala Leu Lys Val Ile Pro Val 
1               5                   10                  15      


Ile Ala Ile Asp Asn Ala Glu Asp Ile Ile Pro Leu Gly Lys Val Leu 
            20                  25                  30          


Ala Glu Asn Gly Leu Pro Ala Ala Glu Ile Thr Phe Arg Ser Ser Ala 
        35                  40                  45              


Ala Val Lys Ala Ile Met Leu Leu Arg Ser Ala Gln Pro Glu Met Leu 
    50                  55                  60                  


Ile Gly Ala Gly Thr Ile Leu Asn Gly Val Gln Ala Leu Ala Ala Lys 
65                  70                  75                  80  


Glu Ala Gly Ala Thr Phe Val Val Ser Pro Gly Phe Asn Pro Asn Thr 
                85                  90                  95      


Val Arg Ala Cys Gln Ile Ile Gly Ile Asp Ile Val Pro Gly Val Asn 
            100                 105                 110         


Asn Pro Ser Thr Val Glu Ala Ala Leu Glu Met Gly Leu Thr Thr Leu 
        115                 120                 125             


Lys Phe Phe Pro Ala Glu Ala Ser Gly Gly Ile Ser Met Val Lys Ser 
    130                 135                 140                 


Leu Val Gly Pro Tyr Gly Asp Ile Arg Leu Met Pro Thr Gly Gly Ile 
145                 150                 155                 160 


Thr Pro Ser Asn Ile Asp Asn Tyr Leu Ala Ile Pro Gln Val Leu Ala 
                165                 170                 175     


Cys Gly Gly Thr Trp Met Val Asp Lys Lys Leu Val Thr Asn Gly Glu 
            180                 185                 190         


Trp Asp Glu Ile Ala Arg Leu Thr Arg Glu Ile Val Glu Gln Val Asn 
        195                 200                 205             


Pro 
    


<210>  5
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-47A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  5

Met Pro Ile Phe Thr Leu Asn Thr Asn Ile Lys Ala Thr Asp Val Pro 
1               5                   10                  15      


Ser Asp Phe Leu Ser Leu Thr Ser Arg Leu Val Gly Leu Ile Leu Ser 
            20                  25                  30          


Lys Pro Gly Ser Tyr Val Ala Val His Ile Asn Thr Asp Gln Gln Leu 
        35                  40                  45              


Ser Phe Gly Gly Ser Thr Asn Pro Ala Ala Phe Gly Thr Leu Met Ser 
    50                  55                  60                  


Ile Gly Gly Ile Glu Pro Ser Lys Asn Arg Asp His Ser Ala Val Leu 
65                  70                  75                  80  


Phe Asp His Leu Asn Ala Met Leu Gly Ile Pro Lys Asn Arg Met Tyr 
                85                  90                  95      


Ile His Phe Val Asn Leu Asn Gly Asp Asp Val Gly Trp Asn Gly Thr 
            100                 105                 110         


Thr Phe 
        


<210>  6
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-47B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  6

Met Asn Gln His Ser His Lys Asp Tyr Glu Thr Val Arg Ile Ala Val 
1               5                   10                  15      


Val Arg Ala Arg Trp His Ala Asp Ile Val Asp Ala Cys Val Glu Ala 
            20                  25                  30          


Phe Glu Ile Ala Met Ala Ala Ile Gly Gly Asp Arg Phe Ala Val Asp 
        35                  40                  45              


Val Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr 
    50                  55                  60                  


Leu Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val 
65                  70                  75                  80  


Val Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile 
                85                  90                  95      


Asp Gly Met Met Asn Val Gln Leu Ser Thr Gly Val Pro Val Leu Ser 
            100                 105                 110         


Ala Val Leu Thr Pro His Arg Tyr Arg Asp Ser Ala Glu His His Arg 
        115                 120                 125             


Phe Phe Ala Ala His Phe Ala Val Lys Gly Val Glu Ala Ala Arg Ala 
    130                 135                 140                 


Cys Ile Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155         


<210>  7
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-50A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  7

Met Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu 
1               5                   10                  15      


Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe 
            20                  25                  30          


Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala 
        35                  40                  45              


Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile 
    50                  55                  60                  


Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val 
65                  70                  75                  80  


Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile 
                85                  90                  95      


Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met 
            100                 105                 110         


Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu 
        115                 120                 125             


Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met 
    130                 135                 140                 


Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn 
145                 150                 155                 160 


Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly 
                165                 170                 175     


Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys 
            180                 185                 190         


Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
        195                 200                 205 


<210>  8
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-50B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  8

Met Asn Gln His Ser His Lys Asp Tyr Glu Thr Val Arg Ile Ala Val 
1               5                   10                  15      


Val Arg Ala Arg Trp His Ala Glu Ile Val Asp Ala Cys Val Ser Ala 
            20                  25                  30          


Phe Glu Ala Ala Met Ala Asp Ile Gly Gly Asp Arg Phe Ala Val Asp 
        35                  40                  45              


Val Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr 
    50                  55                  60                  


Leu Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val 
65                  70                  75                  80  


Val Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile 
                85                  90                  95      


Asp Gly Met Met Asn Val Gln Leu Ser Thr Gly Val Pro Val Leu Ser 
            100                 105                 110         


Ala Val Leu Thr Pro His Arg Tyr Arg Asp Ser Asp Ala His Thr Leu 
        115                 120                 125             


Leu Phe Leu Ala Leu Phe Ala Val Lys Gly Met Glu Ala Ala Arg Ala 
    130                 135                 140                 


Cys Val Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155         


<210>  9
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-51A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  9

Met Phe Thr Lys Ser Gly Asp Asp Gly Asn Thr Asn Val Ile Asn Lys 
1               5                   10                  15      


Arg Val Gly Lys Asp Ser Pro Leu Val Asn Phe Leu Gly Asp Leu Asp 
            20                  25                  30          


Glu Leu Asn Ser Phe Ile Gly Phe Ala Ile Ser Lys Ile Pro Trp Glu 
        35                  40                  45              


Asp Met Lys Lys Asp Leu Glu Arg Val Gln Val Glu Leu Phe Glu Ile 
    50                  55                  60                  


Gly Glu Asp Leu Ser Thr Gln Ser Ser Lys Lys Lys Ile Asp Glu Ser 
65                  70                  75                  80  


Tyr Val Leu Trp Leu Leu Ala Ala Thr Ala Ile Tyr Arg Ile Glu Ser 
                85                  90                  95      


Gly Pro Val Lys Leu Phe Val Ile Pro Gly Gly Ser Glu Glu Ala Ser 
            100                 105                 110         


Val Leu His Val Thr Arg Ser Val Ala Arg Arg Val Glu Arg Asn Ala 
        115                 120                 125             


Val Lys Tyr Thr Lys Glu Leu Pro Glu Ile Asn Arg Met Ile Ile Val 
    130                 135                 140                 


Tyr Leu Asn Arg Leu Ser Ser Leu Leu Phe Ala Met Ala Leu Val Ala 
145                 150                 155                 160 


Asn Lys Arg Arg Asn Gln Ser Glu Lys Ile Tyr Glu Ile Gly Lys Ser 
                165                 170                 175     


Trp 
    


<210>  10
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-51B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  10

Met Asn Gln His Ser His Lys Asp Tyr Glu Thr Val Arg Ile Ala Val 
1               5                   10                  15      


Val Arg Ala Arg Trp His Ala Asp Ile Val Asp Gln Cys Val Arg Ala 
            20                  25                  30          


Phe Glu Glu Ala Met Ala Asp Ala Gly Gly Asp Arg Phe Ala Val Asp 
        35                  40                  45              


Val Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr 
    50                  55                  60                  


Leu Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val 
65                  70                  75                  80  


Val Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile 
                85                  90                  95      


Asp Gly Met Met Asn Val Gln Leu Ser Thr Gly Val Pro Val Leu Ser 
            100                 105                 110         


Ala Val Leu Thr Pro His Arg Tyr Arg Ser Ser Arg Glu His His Glu 
        115                 120                 125             


Phe Phe Arg Glu His Phe Met Val Lys Gly Val Glu Ala Ala Ala Ala 
    130                 135                 140                 


Cys Ile Thr Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155         


<210>  11
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I52-03A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  11

Met Gly His Thr Lys Gly Pro Thr Pro Gln Gln His Asp Gly Ser Ala 
1               5                   10                  15      


Leu Arg Ile Gly Ile Val His Ala Arg Trp Asn Lys Thr Ile Ile Met 
            20                  25                  30          


Pro Leu Leu Ile Gly Thr Ile Ala Lys Leu Leu Glu Cys Gly Val Lys 
        35                  40                  45              


Ala Ser Asn Ile Val Val Gln Ser Val Pro Gly Ser Trp Glu Leu Pro 
    50                  55                  60                  


Ile Ala Val Gln Arg Leu Tyr Ser Ala Ser Gln Leu Gln Thr Pro Ser 
65                  70                  75                  80  


Ser Gly Pro Ser Leu Ser Ala Gly Asp Leu Leu Gly Ser Ser Thr Thr 
                85                  90                  95      


Asp Leu Thr Ala Leu Pro Thr Thr Thr Ala Ser Ser Thr Gly Pro Phe 
            100                 105                 110         


Asp Ala Leu Ile Ala Ile Gly Val Leu Ile Lys Gly Glu Thr Met His 
        115                 120                 125             


Phe Glu Tyr Ile Ala Asp Ser Val Ser His Gly Leu Met Arg Val Gln 
    130                 135                 140                 


Leu Asp Thr Gly Val Pro Val Ile Phe Gly Val Leu Thr Val Leu Thr 
145                 150                 155                 160 


Asp Asp Gln Ala Lys Ala Arg Ala Gly Val Ile Glu Gly Ser His Asn 
                165                 170                 175     


His Gly Glu Asp Trp Gly Leu Ala Ala Val Glu Met Gly Val Arg Arg 
            180                 185                 190         


Arg Asp Trp Ala Ala Gly Lys Thr Glu 
        195                 200     


<210>  12
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I52-03B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  12

Met Tyr Glu Val Asp His Ala Asp Val Tyr Asp Leu Phe Tyr Leu Gly 
1               5                   10                  15      


Arg Gly Lys Asp Tyr Ala Ala Glu Ala Ser Asp Ile Ala Asp Leu Val 
            20                  25                  30          


Arg Ser Arg Thr Pro Glu Ala Ser Ser Leu Leu Asp Val Ala Cys Gly 
        35                  40                  45              


Thr Gly Thr His Leu Glu His Phe Thr Lys Glu Phe Gly Asp Thr Ala 
    50                  55                  60                  


Gly Leu Glu Leu Ser Glu Asp Met Leu Thr His Ala Arg Lys Arg Leu 
65                  70                  75                  80  


Pro Asp Ala Thr Leu His Gln Gly Asp Met Arg Asp Phe Gln Leu Gly 
                85                  90                  95      


Arg Lys Phe Ser Ala Val Val Ser Met Phe Ser Ser Val Gly Tyr Leu 
            100                 105                 110         


Lys Thr Val Ala Glu Leu Gly Ala Ala Val Ala Ser Phe Ala Glu His 
        115                 120                 125             


Leu Glu Pro Gly Gly Val Val Val Val Glu Pro Trp Trp Phe Pro Glu 
    130                 135                 140                 


Thr Phe Ala Asp Gly Trp Val Ser Ala Asp Val Val Arg Arg Asp Gly 
145                 150                 155                 160 


Arg Thr Val Ala Arg Val Ser His Ser Val Arg Glu Gly Asn Ala Thr 
                165                 170                 175     


Arg Met Glu Val His Phe Thr Val Ala Asp Pro Gly Lys Gly Val Arg 
            180                 185                 190         


His Phe Ser Asp Val His Leu Ile Thr Leu Phe His Gln Arg Glu Tyr 
        195                 200                 205             


Glu Ala Ala Phe Met Ala Ala Gly Leu Arg Val Glu Tyr Leu Glu Gly 
    210                 215                 220                 


Gly Pro Ser Gly Arg Gly Leu Phe Val Gly Val Pro Ala 
225                 230                 235         


<210>  13
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I52-32A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  13

Met Gly Met Lys Glu Lys Phe Val Leu Ile Ile Thr His Gly Asp Phe 
1               5                   10                  15      


Gly Lys Gly Leu Leu Ser Gly Ala Glu Val Ile Ile Gly Lys Gln Glu 
            20                  25                  30          


Asn Val His Thr Val Gly Leu Asn Leu Gly Asp Asn Ile Glu Lys Val 
        35                  40                  45              


Ala Lys Glu Val Met Arg Ile Ile Ile Ala Lys Leu Ala Glu Asp Lys 
    50                  55                  60                  


Glu Ile Ile Ile Val Val Asp Leu Phe Gly Gly Ser Pro Phe Asn Ile 
65                  70                  75                  80  


Ala Leu Glu Met Met Lys Thr Phe Asp Val Lys Val Ile Thr Gly Ile 
                85                  90                  95      


Asn Met Pro Met Leu Val Glu Leu Leu Thr Ser Ile Asn Val Tyr Asp 
            100                 105                 110         


Thr Thr Glu Leu Leu Glu Asn Ile Ser Lys Ile Gly Lys Asp Gly Ile 
        115                 120                 125             


Lys Val Ile Glu Lys Ser Ser Leu Lys Met 
    130                 135             


<210>  14
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I52-32B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  14

Met Lys Tyr Asp Gly Ser Lys Leu Arg Ile Gly Ile Leu His Ala Arg 
1               5                   10                  15      


Trp Asn Leu Glu Ile Ile Ala Ala Leu Val Ala Gly Ala Ile Lys Arg 
            20                  25                  30          


Leu Gln Glu Phe Gly Val Lys Ala Glu Asn Ile Ile Ile Glu Thr Val 
        35                  40                  45              


Pro Gly Ser Phe Glu Leu Pro Tyr Gly Ser Lys Leu Phe Val Glu Lys 
    50                  55                  60                  


Gln Lys Arg Leu Gly Lys Pro Leu Asp Ala Ile Ile Pro Ile Gly Val 
65                  70                  75                  80  


Leu Ile Lys Gly Ser Thr Met His Phe Glu Tyr Ile Cys Asp Ser Thr 
                85                  90                  95      


Thr His Gln Leu Met Lys Leu Asn Phe Glu Leu Gly Ile Pro Val Ile 
            100                 105                 110         


Phe Gly Val Leu Thr Cys Leu Thr Asp Glu Gln Ala Glu Ala Arg Ala 
        115                 120                 125             


Gly Leu Ile Glu Gly Lys Met His Asn His Gly Glu Asp Trp Gly Ala 
    130                 135                 140                 


Ala Ala Val Glu Met Ala Thr Lys Phe Asn 
145                 150                 


<210>  15
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I52-33A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  15

Met Ala Val Lys Gly Leu Gly Glu Val Asp Gln Lys Tyr Asp Gly Ser 
1               5                   10                  15      


Lys Leu Arg Ile Gly Ile Leu His Ala Arg Trp Asn Arg Lys Ile Ile 
            20                  25                  30          


Leu Ala Leu Val Ala Gly Ala Val Leu Arg Leu Leu Glu Phe Gly Val 
        35                  40                  45              


Lys Ala Glu Asn Ile Ile Ile Glu Thr Val Pro Gly Ser Phe Glu Leu 
    50                  55                  60                  


Pro Tyr Gly Ser Lys Leu Phe Val Glu Lys Gln Lys Arg Leu Gly Lys 
65                  70                  75                  80  


Pro Leu Asp Ala Ile Ile Pro Ile Gly Val Leu Ile Lys Gly Ser Thr 
                85                  90                  95      


Met His Phe Glu Tyr Ile Cys Asp Ser Thr Thr His Gln Leu Met Lys 
            100                 105                 110         


Leu Asn Phe Glu Leu Gly Ile Pro Val Ile Phe Gly Val Leu Thr Cys 
        115                 120                 125             


Leu Thr Asp Glu Gln Ala Glu Ala Arg Ala Gly Leu Ile Glu Gly Lys 
    130                 135                 140                 


Met His Asn His Gly Glu Asp Trp Gly Ala Ala Ala Val Glu Met Ala 
145                 150                 155                 160 


Thr Lys Phe Asn 
                


<210>  16
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I52-33B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  16

Met Gly Ala Asn Trp Tyr Leu Asp Asn Glu Ser Ser Arg Leu Ser Phe 
1               5                   10                  15      


Thr Ser Thr Lys Asn Ala Asp Ile Ala Glu Val His Arg Phe Leu Val 
            20                  25                  30          


Leu His Gly Lys Val Asp Pro Lys Gly Leu Ala Glu Val Glu Val Glu 
        35                  40                  45              


Thr Glu Ser Ile Ser Thr Gly Ile Pro Leu Arg Asp Met Leu Leu Arg 
    50                  55                  60                  


Val Leu Val Phe Gln Val Ser Lys Phe Pro Val Ala Gln Ile Asn Ala 
65                  70                  75                  80  


Gln Leu Asp Met Arg Pro Ile Asn Asn Leu Ala Pro Gly Ala Gln Leu 
                85                  90                  95      


Glu Leu Arg Leu Pro Leu Thr Val Ser Leu Arg Gly Lys Ser His Ser 
            100                 105                 110         


Tyr Asn Ala Glu Leu Leu Ala Thr Arg Leu Asp Glu Arg Arg Phe Gln 
        115                 120                 125             


Val Val Thr Leu Glu Pro Leu Val Ile His Ala Gln Asp Phe Asp Met 
    130                 135                 140                 


Val Arg Ala Phe Asn Ala Leu Arg Leu Val Ala Gly Leu Ser Ala Val 
145                 150                 155                 160 


Ser Leu Ser Val Pro Val Gly Ala Val Leu Ile Phe Thr Ala Arg 
                165                 170                 175 


<210>  17
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I32-06A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  17

Met Thr Asp Tyr Ile Arg Asp Gly Ser Ala Ile Lys Ala Leu Ser Phe 
1               5                   10                  15      


Ala Ile Ile Leu Ala Glu Ala Asp Leu Arg His Ile Pro Gln Asp Leu 
            20                  25                  30          


Gln Arg Leu Ala Val Arg Val Ile His Ala Cys Gly Met Val Asp Val 
        35                  40                  45              


Ala Asn Asp Leu Ala Phe Ser Glu Gly Ala Gly Lys Ala Gly Arg Asn 
    50                  55                  60                  


Ala Leu Leu Ala Gly Ala Pro Ile Leu Cys Asp Ala Arg Met Val Ala 
65                  70                  75                  80  


Glu Gly Ile Thr Arg Ser Arg Leu Pro Ala Asp Asn Arg Val Ile Tyr 
                85                  90                  95      


Thr Leu Ser Asp Pro Ser Val Pro Glu Leu Ala Lys Lys Ile Gly Asn 
            100                 105                 110         


Thr Arg Ser Ala Ala Ala Leu Asp Leu Trp Leu Pro His Ile Glu Gly 
        115                 120                 125             


Ser Ile Val Ala Ile Gly Asn Ala Pro Thr Ala Leu Phe Arg Leu Phe 
    130                 135                 140                 


Glu Leu Leu Asp Ala Gly Ala Pro Lys Pro Ala Leu Ile Ile Gly Met 
145                 150                 155                 160 


Pro Val Gly Phe Val Gly Ala Ala Glu Ser Lys Asp Glu Leu Ala Ala 
                165                 170                 175     


Asn Ser Arg Gly Val Pro Tyr Val Ile Val Arg Gly Arg Arg Gly Gly 
            180                 185                 190         


Ser Ala Met Thr Ala Ala Ala Val Asn Ala Leu Ala Ser Glu Arg Glu 
        195                 200                 205             


<210>  18
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I32-06B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  18

Met Ile Thr Val Phe Gly Leu Lys Ser Lys Leu Ala Pro Arg Arg Glu 
1               5                   10                  15      


Lys Leu Ala Glu Val Ile Tyr Ser Ser Leu His Leu Gly Leu Asp Ile 
            20                  25                  30          


Pro Lys Gly Lys His Ala Ile Arg Phe Leu Cys Leu Glu Lys Glu Asp 
        35                  40                  45              


Phe Tyr Tyr Pro Phe Asp Arg Ser Asp Asp Tyr Thr Val Ile Glu Ile 
    50                  55                  60                  


Asn Leu Met Ala Gly Arg Ser Glu Glu Thr Lys Met Leu Leu Ile Phe 
65                  70                  75                  80  


Leu Leu Phe Ile Ala Leu Glu Arg Lys Leu Gly Ile Arg Ala His Asp 
                85                  90                  95      


Val Glu Ile Thr Ile Lys Glu Gln Pro Ala His Cys Trp Gly Phe Arg 
            100                 105                 110         


Gly Arg Thr Gly Asp Ser Ala Arg Asp Leu Asp Tyr Asp Ile Tyr Val 
        115                 120                 125             


<210>  19
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I32-19A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  19

Met Gly Ser Asp Leu Gln Lys Leu Gln Arg Phe Ser Thr Cys Asp Ile 
1               5                   10                  15      


Ser Asp Gly Leu Leu Asn Val Tyr Asn Ile Pro Thr Gly Gly Tyr Phe 
            20                  25                  30          


Pro Asn Leu Thr Ala Ile Ser Pro Pro Gln Asn Ser Ser Ile Val Gly 
        35                  40                  45              


Thr Ala Tyr Thr Val Leu Phe Ala Pro Ile Asp Asp Pro Arg Pro Ala 
    50                  55                  60                  


Val Asn Tyr Ile Asp Ser Val Pro Pro Asn Ser Ile Leu Val Leu Ala 
65                  70                  75                  80  


Leu Glu Pro His Leu Gln Ser Gln Phe His Pro Phe Ile Lys Ile Thr 
                85                  90                  95      


Gln Ala Met Tyr Gly Gly Leu Met Ser Thr Arg Ala Gln Tyr Leu Lys 
            100                 105                 110         


Ser Asn Gly Thr Val Val Phe Gly Arg Ile Arg Asp Val Asp Glu His 
        115                 120                 125             


Arg Thr Leu Asn His Pro Val Phe Ala Tyr Gly Val Gly Ser Cys Ala 
    130                 135                 140                 


Pro Lys Ala Val Val Lys Ala Val Gly Thr Asn Val Gln Leu Lys Ile 
145                 150                 155                 160 


Leu Thr Ser Asp Gly Val Thr Gln Thr Ile Cys Pro Gly Asp Tyr Ile 
                165                 170                 175     


Ala Gly Asp Asn Asn Gly Ile Val Arg Ile Pro Val Gln Glu Thr Asp 
            180                 185                 190         


Ile Ser Lys Leu Val Thr Tyr Ile Glu Lys Ser Ile Glu Val Asp Arg 
        195                 200                 205             


Leu Val Ser Glu Ala Ile Lys Asn Gly Leu Pro Ala Lys Ala Ala Gln 
    210                 215                 220                 


Thr Ala Arg Arg Met Val Leu Lys Asp Tyr Ile 
225                 230                 235 


<210>  20
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I32-19B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  20

Met Ser Gly Met Arg Val Tyr Leu Gly Ala Asp His Ala Gly Tyr Glu 
1               5                   10                  15      


Leu Lys Gln Ala Ile Ile Ala Phe Leu Lys Met Thr Gly His Glu Pro 
            20                  25                  30          


Ile Asp Cys Gly Ala Leu Arg Tyr Asp Ala Asp Asp Asp Tyr Pro Ala 
        35                  40                  45              


Phe Cys Ile Ala Ala Ala Thr Arg Thr Val Ala Asp Pro Gly Ser Leu 
    50                  55                  60                  


Gly Ile Val Leu Gly Gly Ser Gly Asn Gly Glu Gln Ile Ala Ala Asn 
65                  70                  75                  80  


Lys Val Pro Gly Ala Arg Cys Ala Leu Ala Trp Ser Val Gln Thr Ala 
                85                  90                  95      


Ala Leu Ala Arg Glu His Asn Asn Ala Gln Leu Ile Gly Ile Gly Gly 
            100                 105                 110         


Arg Met His Thr Leu Glu Glu Ala Leu Arg Ile Val Lys Ala Phe Val 
        115                 120                 125             


Thr Thr Pro Trp Ser Lys Ala Gln Arg His Gln Arg Arg Ile Asp Ile 
    130                 135                 140                 


Leu Ala Glu Tyr Glu Arg Thr His Glu Ala Pro Pro Val Pro Gly Ala 
145                 150                 155                 160 


Pro Ala 
        


<210>  21
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I32-28A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  21

Met Gly Asp Asp Ala Arg Ile Ala Ala Ile Gly Asp Val Asp Glu Leu 
1               5                   10                  15      


Asn Ser Gln Ile Gly Val Leu Leu Ala Glu Pro Leu Pro Asp Asp Val 
            20                  25                  30          


Arg Ala Ala Leu Ser Ala Ile Gln His Asp Leu Phe Asp Leu Gly Gly 
        35                  40                  45              


Glu Leu Cys Ile Pro Gly His Ala Ala Ile Thr Glu Asp His Leu Leu 
    50                  55                  60                  


Arg Leu Ala Leu Trp Leu Val His Tyr Asn Gly Gln Leu Pro Pro Leu 
65                  70                  75                  80  


Glu Glu Phe Ile Leu Pro Gly Gly Ala Arg Gly Ala Ala Leu Ala His 
                85                  90                  95      


Val Cys Arg Thr Val Cys Arg Arg Ala Glu Arg Ser Ile Lys Ala Leu 
            100                 105                 110         


Gly Ala Ser Glu Pro Leu Asn Ile Ala Pro Ala Ala Tyr Val Asn Leu 
        115                 120                 125             


Leu Ser Asp Leu Leu Phe Val Leu Ala Arg Val Leu Asn Arg Ala Ala 
    130                 135                 140                 


Gly Gly Ala Asp Val Leu Trp Asp Arg Thr Arg Ala His 
145                 150                 155         


<210>  22
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I32-28B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  22

Met Ile Leu Ser Ala Glu Gln Ser Phe Thr Leu Arg His Pro His Gly 
1               5                   10                  15      


Gln Ala Ala Ala Leu Ala Phe Val Arg Glu Pro Ala Ala Ala Leu Ala 
            20                  25                  30          


Gly Val Gln Arg Leu Arg Gly Leu Asp Ser Asp Gly Glu Gln Val Trp 
        35                  40                  45              


Gly Glu Leu Leu Val Arg Val Pro Leu Leu Gly Glu Val Asp Leu Pro 
    50                  55                  60                  


Phe Arg Ser Glu Ile Val Arg Thr Pro Gln Gly Ala Glu Leu Arg Pro 
65                  70                  75                  80  


Leu Thr Leu Thr Gly Glu Arg Ala Trp Val Ala Val Ser Gly Gln Ala 
                85                  90                  95      


Thr Ala Ala Glu Gly Gly Glu Met Ala Phe Ala Phe Gln Phe Gln Ala 
            100                 105                 110         


His Leu Ala Thr Pro Glu Ala Glu Gly Glu Gly Gly Ala Ala Phe Glu 
        115                 120                 125             


Val Met Val Gln Ala Ala Ala Gly Val Thr Leu Leu Leu Val Ala Met 
    130                 135                 140                 


Ala Leu Pro Gln Gly Leu Ala Ala Gly Leu Pro Pro Ala 
145                 150                 155         


<210>  23
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-40A.1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  23

Met Thr Lys Lys Val Gly Ile Val Asp Thr Thr Phe Ala Arg Val Asp 
1               5                   10                  15      


Met Ala Ser Ala Ala Ile Leu Thr Leu Lys Met Glu Ser Pro Asn Ile 
            20                  25                  30          


Lys Ile Ile Arg Lys Thr Val Pro Gly Ile Lys Asp Leu Pro Val Ala 
        35                  40                  45              


Cys Lys Lys Leu Leu Glu Glu Glu Gly Cys Asp Ile Val Met Ala Leu 
    50                  55                  60                  


Gly Met Pro Gly Lys Lys Glu Lys Asp Lys Val Cys Ala His Glu Ala 
65                  70                  75                  80  


Ser Leu Gly Leu Met Leu Ala Gln Leu Met Thr Asn Lys His Ile Ile 
                85                  90                  95      


Glu Val Phe Val His Glu Asp Glu Ala Lys Asp Asp Ala Glu Leu Lys 
            100                 105                 110         


Ile Leu Ala Ala Arg Arg Ala Ile Glu His Ala Leu Asn Val Tyr Tyr 
        115                 120                 125             


Leu Leu Phe Lys Pro Glu Tyr Leu Thr Arg Met Ala Gly Lys Gly Leu 
    130                 135                 140                 


Arg Gln Gly Phe Glu Asp Ala Gly Pro Ala Arg Glu 
145                 150                 155     


<210>  24
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-40B.1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  24

Met Asp Asp Ile Asn Asn Gln Leu Lys Arg Leu Lys Val Ile Pro Val 
1               5                   10                  15      


Ile Ala Ile Asp Asn Ala Glu Asp Ile Ile Pro Leu Gly Lys Val Leu 
            20                  25                  30          


Ala Glu Asn Gly Leu Pro Ala Ala Glu Ile Thr Phe Arg Ser Ser Ala 
        35                  40                  45              


Ala Val Lys Ala Ile Met Leu Leu Arg Ser Ala Gln Pro Glu Met Leu 
    50                  55                  60                  


Ile Gly Ala Gly Thr Ile Leu Asn Gly Val Gln Ala Leu Ala Ala Lys 
65                  70                  75                  80  


Glu Ala Gly Ala Asp Phe Val Val Ser Pro Gly Phe Asn Pro Asn Thr 
                85                  90                  95      


Val Arg Ala Cys Gln Ile Ile Gly Ile Asp Ile Val Pro Gly Val Asn 
            100                 105                 110         


Asn Pro Ser Thr Val Glu Gln Ala Leu Glu Met Gly Leu Thr Thr Leu 
        115                 120                 125             


Lys Phe Phe Pro Ala Glu Ala Ser Gly Gly Ile Ser Met Val Lys Ser 
    130                 135                 140                 


Leu Val Gly Pro Tyr Gly Asp Ile Arg Leu Met Pro Thr Gly Gly Ile 
145                 150                 155                 160 


Thr Pro Asp Asn Ile Asp Asn Tyr Leu Ala Ile Pro Gln Val Leu Ala 
                165                 170                 175     


Cys Gly Gly Thr Trp Met Val Asp Lys Lys Leu Val Arg Asn Gly Glu 
            180                 185                 190         


Trp Asp Glu Ile Ala Arg Leu Thr Arg Glu Ile Val Glu Gln Val Asn 
        195                 200                 205             


Pro 
    


<210>  25
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-47A.1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  25

Met Pro Ile Phe Thr Leu Asn Thr Asn Ile Lys Ala Asp Asp Val Pro 
1               5                   10                  15      


Ser Asp Phe Leu Ser Leu Thr Ser Arg Leu Val Gly Leu Ile Leu Ser 
            20                  25                  30          


Lys Pro Gly Ser Tyr Val Ala Val His Ile Asn Thr Asp Gln Gln Leu 
        35                  40                  45              


Ser Phe Gly Gly Ser Thr Asn Pro Ala Ala Phe Gly Thr Leu Met Ser 
    50                  55                  60                  


Ile Gly Gly Ile Glu Pro Asp Lys Asn Arg Asp His Ser Ala Val Leu 
65                  70                  75                  80  


Phe Asp His Leu Asn Ala Met Leu Gly Ile Pro Lys Asn Arg Met Tyr 
                85                  90                  95      


Ile His Phe Val Asn Leu Asn Gly Asp Asp Val Gly Trp Asn Gly Thr 
            100                 105                 110         


Thr Phe 
        


<210>  26
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-47A.1NegT2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  26

Met Pro Ile Phe Thr Leu Asn Thr Asn Ile Lys Ala Asp Asp Val Pro 
1               5                   10                  15      


Ser Asp Phe Leu Ser Leu Thr Ser Arg Leu Val Gly Leu Ile Leu Ser 
            20                  25                  30          


Glu Pro Gly Ser Tyr Val Ala Val His Ile Asn Thr Asp Gln Gln Leu 
        35                  40                  45              


Ser Phe Gly Gly Ser Thr Asn Pro Ala Ala Phe Gly Thr Leu Met Ser 
    50                  55                  60                  


Ile Gly Gly Ile Glu Pro Asp Lys Asn Glu Asp His Ser Ala Val Leu 
65                  70                  75                  80  


Phe Asp His Leu Asn Ala Met Leu Gly Ile Pro Lys Asn Arg Met Tyr 
                85                  90                  95      


Ile His Phe Val Asp Leu Asp Gly Asp Asp Val Gly Trp Asn Gly Thr 
            100                 105                 110         


Thr Phe 
        


<210>  27
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-47B.1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  27

Met Asn Gln His Ser His Lys Asp His Glu Thr Val Arg Ile Ala Val 
1               5                   10                  15      


Val Arg Ala Arg Trp His Ala Asp Ile Val Asp Ala Cys Val Glu Ala 
            20                  25                  30          


Phe Glu Ile Ala Met Ala Ala Ile Gly Gly Asp Arg Phe Ala Val Asp 
        35                  40                  45              


Val Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr 
    50                  55                  60                  


Leu Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val 
65                  70                  75                  80  


Val Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile 
                85                  90                  95      


Asp Gly Met Met Asn Val Gln Leu Asp Thr Gly Val Pro Val Leu Ser 
            100                 105                 110         


Ala Val Leu Thr Pro His Arg Tyr Arg Asp Ser Asp Glu His His Arg 
        115                 120                 125             


Phe Phe Ala Ala His Phe Ala Val Lys Gly Val Glu Ala Ala Arg Ala 
    130                 135                 140                 


Cys Ile Glu Ile Leu Asn Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155         


<210>  28
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-47B.1NegT2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  28

Met Asn Gln His Ser His Lys Asp His Glu Thr Val Arg Ile Ala Val 
1               5                   10                  15      


Val Arg Ala Arg Trp His Ala Asp Ile Val Asp Ala Cys Val Glu Ala 
            20                  25                  30          


Phe Glu Ile Ala Met Ala Ala Ile Gly Gly Asp Arg Phe Ala Val Asp 
        35                  40                  45              


Val Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr 
    50                  55                  60                  


Leu Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val 
65                  70                  75                  80  


Val Asp Gly Gly Ile Tyr Asp His Glu Phe Val Ala Ser Ala Val Ile 
                85                  90                  95      


Asp Gly Met Met Asn Val Gln Leu Asp Thr Gly Val Pro Val Leu Ser 
            100                 105                 110         


Ala Val Leu Thr Pro His Glu Tyr Glu Asp Ser Asp Glu Asp His Glu 
        115                 120                 125             


Phe Phe Ala Ala His Phe Ala Val Lys Gly Val Glu Ala Ala Arg Ala 
    130                 135                 140                 


Cys Ile Glu Ile Leu Asn Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155         


<210>  29
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-50A.1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  29

Met Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu 
1               5                   10                  15      


Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe 
            20                  25                  30          


Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala 
        35                  40                  45              


Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile 
    50                  55                  60                  


Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val 
65                  70                  75                  80  


Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile 
                85                  90                  95      


Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met 
            100                 105                 110         


Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Asp Ile Leu 
        115                 120                 125             


Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met 
    130                 135                 140                 


Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn 
145                 150                 155                 160 


Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly 
                165                 170                 175     


Val Gly Asp Ala Leu Val Lys Gly Asp Pro Asp Glu Val Arg Glu Lys 
            180                 185                 190         


Ala Lys Lys Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
        195                 200                 205 


<210>  30
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-50A.1NegT2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  30

Met Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu 
1               5                   10                  15      


Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe 
            20                  25                  30          


Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala 
        35                  40                  45              


Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile 
    50                  55                  60                  


Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val 
65                  70                  75                  80  


Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile 
                85                  90                  95      


Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met 
            100                 105                 110         


Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Asp Ile Leu 
        115                 120                 125             


Lys Leu Phe Pro Gly Glu Val Val Gly Pro Glu Phe Val Glu Ala Met 
    130                 135                 140                 


Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asp 
145                 150                 155                 160 


Leu Asp Asp Val Cys Glu Trp Phe Asp Ala Gly Val Leu Ala Val Gly 
                165                 170                 175     


Val Gly Asp Ala Leu Val Glu Gly Asp Pro Asp Glu Val Arg Glu Asp 
            180                 185                 190         


Ala Lys Glu Phe Val Glu Glu Ile Arg Gly Cys Thr Glu 
        195                 200                 205 


<210>  31
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-50A.1PosT1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  31

Met Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu 
1               5                   10                  15      


Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe 
            20                  25                  30          


Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala 
        35                  40                  45              


Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile 
    50                  55                  60                  


Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val 
65                  70                  75                  80  


Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile 
                85                  90                  95      


Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met 
            100                 105                 110         


Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Asp Ile Leu 
        115                 120                 125             


Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met 
    130                 135                 140                 


Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn 
145                 150                 155                 160 


Leu Asp Asn Val Cys Lys Trp Phe Lys Ala Gly Val Leu Ala Val Gly 
                165                 170                 175     


Val Gly Lys Ala Leu Val Lys Gly Lys Pro Asp Glu Val Arg Glu Lys 
            180                 185                 190         


Ala Lys Lys Phe Val Lys Lys Ile Arg Gly Cys Thr Glu 
        195                 200                 205 


<210>  32
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-50B.1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  32

Met Asn Gln His Ser His Lys Asp His Glu Thr Val Arg Ile Ala Val 
1               5                   10                  15      


Val Arg Ala Arg Trp His Ala Glu Ile Val Asp Ala Cys Val Ser Ala 
            20                  25                  30          


Phe Glu Ala Ala Met Arg Asp Ile Gly Gly Asp Arg Phe Ala Val Asp 
        35                  40                  45              


Val Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr 
    50                  55                  60                  


Leu Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val 
65                  70                  75                  80  


Val Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile 
                85                  90                  95      


Asp Gly Met Met Asn Val Gln Leu Asp Thr Gly Val Pro Val Leu Ser 
            100                 105                 110         


Ala Val Leu Thr Pro His Arg Tyr Arg Asp Ser Asp Ala His Thr Leu 
        115                 120                 125             


Leu Phe Leu Ala Leu Phe Ala Val Lys Gly Met Glu Ala Ala Arg Ala 
    130                 135                 140                 


Cys Val Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155         


<210>  33
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-50B.1NegT2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  33

Met Asn Gln His Ser His Lys Asp His Glu Thr Val Arg Ile Ala Val 
1               5                   10                  15      


Val Arg Ala Arg Trp His Ala Glu Ile Val Asp Ala Cys Val Ser Ala 
            20                  25                  30          


Phe Glu Ala Ala Met Arg Asp Ile Gly Gly Asp Arg Phe Ala Val Asp 
        35                  40                  45              


Val Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr 
    50                  55                  60                  


Leu Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val 
65                  70                  75                  80  


Val Asp Gly Gly Ile Tyr Asp His Glu Phe Val Ala Ser Ala Val Ile 
                85                  90                  95      


Asp Gly Met Met Asn Val Gln Leu Asp Thr Gly Val Pro Val Leu Ser 
            100                 105                 110         


Ala Val Leu Thr Pro His Glu Tyr Glu Asp Ser Asp Ala Asp Thr Leu 
        115                 120                 125             


Leu Phe Leu Ala Leu Phe Ala Val Lys Gly Met Glu Ala Ala Arg Ala 
    130                 135                 140                 


Cys Val Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155         


<210>  34
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-50B.4PosT1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  34

Met Asn Gln His Ser His Lys Asp His Glu Thr Val Arg Ile Ala Val 
1               5                   10                  15      


Val Arg Ala Arg Trp His Ala Glu Ile Val Asp Ala Cys Val Ser Ala 
            20                  25                  30          


Phe Glu Ala Ala Met Arg Asp Ile Gly Gly Asp Arg Phe Ala Val Asp 
        35                  40                  45              


Val Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr 
    50                  55                  60                  


Leu Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val 
65                  70                  75                  80  


Val Asn Gly Gly Ile Tyr Arg His Glu Phe Val Ala Ser Ala Val Ile 
                85                  90                  95      


Asn Gly Met Met Asn Val Gln Leu Asn Thr Gly Val Pro Val Leu Ser 
            100                 105                 110         


Ala Val Leu Thr Pro His Asn Tyr Asp Lys Ser Lys Ala His Thr Leu 
        115                 120                 125             


Leu Phe Leu Ala Leu Phe Ala Val Lys Gly Met Glu Ala Ala Arg Ala 
    130                 135                 140                 


Cys Val Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155         


<210>  35
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-40 A genus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa is A or K

<400>  35

Met Thr Lys Lys Val Gly Ile Val Asp Thr Thr Phe Ala Arg Val Asp 
1               5                   10                  15      


Met Ala Ser Ala Ala Ile Leu Thr Leu Lys Met Glu Ser Pro Asn Ile 
            20                  25                  30          


Lys Ile Ile Arg Lys Thr Val Pro Gly Ile Lys Asp Leu Pro Val Ala 
        35                  40                  45              


Cys Lys Lys Leu Leu Glu Glu Glu Gly Cys Asp Ile Val Met Ala Leu 
    50                  55                  60                  


Gly Met Pro Gly Lys Xaa Glu Lys Asp Lys Val Cys Ala His Glu Ala 
65                  70                  75                  80  


Ser Leu Gly Leu Met Leu Ala Gln Leu Met Thr Asn Lys His Ile Ile 
                85                  90                  95      


Glu Val Phe Val His Glu Asp Glu Ala Lys Asp Asp Ala Glu Leu Lys 
            100                 105                 110         


Ile Leu Ala Ala Arg Arg Ala Ile Glu His Ala Leu Asn Val Tyr Tyr 
        115                 120                 125             


Leu Leu Phe Lys Pro Glu Tyr Leu Thr Arg Met Ala Gly Lys Gly Leu 
    130                 135                 140                 


Arg Gln Gly Phe Glu Asp Ala Gly Pro Ala Arg Glu 
145                 150                 155     


<210>  36
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-40 B genus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is S or D

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is T or D

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is A or R

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Xaa is T or D

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  Xaa is A or Q

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  Xaa is S or D

<220>
<221>  MISC_FEATURE
<222>  (189)..(189)
<223>  Xaa is T or R

<400>  36

Met Xaa Xaa Ile Asn Asn Gln Leu Lys Xaa Leu Lys Val Ile Pro Val 
1               5                   10                  15      


Ile Ala Ile Asp Asn Ala Glu Asp Ile Ile Pro Leu Gly Lys Val Leu 
            20                  25                  30          


Ala Glu Asn Gly Leu Pro Ala Ala Glu Ile Thr Phe Arg Ser Ser Ala 
        35                  40                  45              


Ala Val Lys Ala Ile Met Leu Leu Arg Ser Ala Gln Pro Glu Met Leu 
    50                  55                  60                  


Ile Gly Ala Gly Thr Ile Leu Asn Gly Val Gln Ala Leu Ala Ala Lys 
65                  70                  75                  80  


Glu Ala Gly Ala Xaa Phe Val Val Ser Pro Gly Phe Asn Pro Asn Thr 
                85                  90                  95      


Val Arg Ala Cys Gln Ile Ile Gly Ile Asp Ile Val Pro Gly Val Asn 
            100                 105                 110         


Asn Pro Ser Thr Val Glu Xaa Ala Leu Glu Met Gly Leu Thr Thr Leu 
        115                 120                 125             


Lys Phe Phe Pro Ala Glu Ala Ser Gly Gly Ile Ser Met Val Lys Ser 
    130                 135                 140                 


Leu Val Gly Pro Tyr Gly Asp Ile Arg Leu Met Pro Thr Gly Gly Ile 
145                 150                 155                 160 


Thr Pro Xaa Asn Ile Asp Asn Tyr Leu Ala Ile Pro Gln Val Leu Ala 
                165                 170                 175     


Cys Gly Gly Thr Trp Met Val Asp Lys Lys Leu Val Xaa Asn Gly Glu 
            180                 185                 190         


Trp Asp Glu Ile Ala Arg Leu Thr Arg Glu Ile Val Glu Gln Val Asn 
        195                 200                 205             


Pro 
    


<210>  37
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-47A genus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is T or D

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa is K or E

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  Xaa is S or D

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa is R or E

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa is N or D

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  Xaa is N or D

<400>  37

Met Pro Ile Phe Thr Leu Asn Thr Asn Ile Lys Ala Xaa Asp Val Pro 
1               5                   10                  15      


Ser Asp Phe Leu Ser Leu Thr Ser Arg Leu Val Gly Leu Ile Leu Ser 
            20                  25                  30          


Xaa Pro Gly Ser Tyr Val Ala Val His Ile Asn Thr Asp Gln Gln Leu 
        35                  40                  45              


Ser Phe Gly Gly Ser Thr Asn Pro Ala Ala Phe Gly Thr Leu Met Ser 
    50                  55                  60                  


Ile Gly Gly Ile Glu Pro Xaa Lys Asn Xaa Asp His Ser Ala Val Leu 
65                  70                  75                  80  


Phe Asp His Leu Asn Ala Met Leu Gly Ile Pro Lys Asn Arg Met Tyr 
                85                  90                  95      


Ile His Phe Val Xaa Leu Xaa Gly Asp Asp Val Gly Trp Asn Gly Thr 
            100                 105                 110         


Thr Phe 
        


<210>  38
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-47B genus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Y or H

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa is N or D

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  Xaa is R or D

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is S or D

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  Xaa is R or E

<220>
<221>  MISC_FEATURE
<222>  (121)..(121)
<223>  Xaa is R or E

<220>
<221>  MISC_FEATURE
<222>  (124)..(124)
<223>  Xaa is A or D

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  Xaa is H or D

<220>
<221>  MISC_FEATURE
<222>  (128)..(128)
<223>  Xaa is R or E

<220>
<221>  MISC_FEATURE
<222>  (150)..(150)
<223>  Xaa is A or N

<400>  38

Met Asn Gln His Ser His Lys Asp Xaa Glu Thr Val Arg Ile Ala Val 
1               5                   10                  15      


Val Arg Ala Arg Trp His Ala Asp Ile Val Asp Ala Cys Val Glu Ala 
            20                  25                  30          


Phe Glu Ile Ala Met Ala Ala Ile Gly Gly Asp Arg Phe Ala Val Asp 
        35                  40                  45              


Val Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr 
    50                  55                  60                  


Leu Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val 
65                  70                  75                  80  


Val Xaa Gly Gly Ile Tyr Xaa His Glu Phe Val Ala Ser Ala Val Ile 
                85                  90                  95      


Asp Gly Met Met Asn Val Gln Leu Xaa Thr Gly Val Pro Val Leu Ser 
            100                 105                 110         


Ala Val Leu Thr Pro His Xaa Tyr Xaa Asp Ser Xaa Glu Xaa His Xaa 
        115                 120                 125             


Phe Phe Ala Ala His Phe Ala Val Lys Gly Val Glu Ala Ala Arg Ala 
    130                 135                 140                 


Cys Ile Glu Ile Leu Xaa Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155         


<210>  39
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-50A genus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  Xaa is T or D

<220>
<221>  MISC_FEATURE
<222>  (139)..(139)
<223>  Xaa is Q or E

<220>
<221>  MISC_FEATURE
<222>  (142)..(142)
<223>  Xaa is K or E

<220>
<221>  MISC_FEATURE
<222>  (160)..(160)
<223>  Xaa is N or D

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  Xaa is N or D

<220>
<221>  MISC_FEATURE
<222>  (166)..(166)
<223>  Xaa is E or K

<220>
<221>  MISC_FEATURE
<222>  (169)..(169)
<223>  Xaa is D or K

<220>
<221>  MISC_FEATURE
<222>  (179)..(179)
<223>  Xaa is S, D or K

<220>
<221>  MISC_FEATURE
<222>  (183)..(183)
<223>  Xaa is K or E

<220>
<221>  MISC_FEATURE
<222>  (185)..(185)
<223>  Xaa is T, D, or K

<220>
<221>  MISC_FEATURE
<222>  (192)..(192)
<223>  Xaa is D or K

<220>
<221>  MISC_FEATURE
<222>  (195)..(195)
<223>  Xaa is A, E, or K

<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  Xaa is E or K

<220>
<221>  MISC_FEATURE
<222>  (199)..(199)
<223>  Xaa is E or K

<400>  39

Met Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu 
1               5                   10                  15      


Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe 
            20                  25                  30          


Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala 
        35                  40                  45              


Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile 
    50                  55                  60                  


Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val 
65                  70                  75                  80  


Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile 
                85                  90                  95      


Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met 
            100                 105                 110         


Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Xaa Ile Leu 
        115                 120                 125             


Lys Leu Phe Pro Gly Glu Val Val Gly Pro Xaa Phe Val Xaa Ala Met 
    130                 135                 140                 


Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Xaa 
145                 150                 155                 160 


Leu Asp Xaa Val Cys Xaa Trp Phe Xaa Ala Gly Val Leu Ala Val Gly 
                165                 170                 175     


Val Gly Xaa Ala Leu Val Xaa Gly Xaa Pro Asp Glu Val Arg Glu Xaa 
            180                 185                 190         


Ala Lys Xaa Phe Val Xaa Xaa Ile Arg Gly Cys Thr Glu 
        195                 200                 205 


<210>  40
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I53-50B genus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Y or H

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa is A or R

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa is N or D

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  Xaa is R or D

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  Xaa is N or D

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is S, N, or D

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  Xaa is R, E, or N

<220>
<221>  MISC_FEATURE
<222>  (121)..(121)
<223>  Xaa is R, E, or D

<220>
<221>  MISC_FEATURE
<222>  (122)..(122)
<223>  Xaa is K or D

<220>
<221>  MISC_FEATURE
<222>  (124)..(124)
<223>  Xaa is K or D

<220>
<221>  MISC_FEATURE
<222>  (126)..(126)
<223>  Xaa is H or D

<400>  40

Met Asn Gln His Ser His Lys Asp Xaa Glu Thr Val Arg Ile Ala Val 
1               5                   10                  15      


Val Arg Ala Arg Trp His Ala Glu Ile Val Asp Ala Cys Val Ser Ala 
            20                  25                  30          


Phe Glu Ala Ala Met Xaa Asp Ile Gly Gly Asp Arg Phe Ala Val Asp 
        35                  40                  45              


Val Phe Asp Val Pro Gly Ala Tyr Glu Ile Pro Leu His Ala Arg Thr 
    50                  55                  60                  


Leu Ala Glu Thr Gly Arg Tyr Gly Ala Val Leu Gly Thr Ala Phe Val 
65                  70                  75                  80  


Val Xaa Gly Gly Ile Tyr Xaa His Glu Phe Val Ala Ser Ala Val Ile 
                85                  90                  95      


Xaa Gly Met Met Asn Val Gln Leu Xaa Thr Gly Val Pro Val Leu Ser 
            100                 105                 110         


Ala Val Leu Thr Pro His Xaa Tyr Xaa Xaa Ser Xaa Ala Xaa Thr Leu 
        115                 120                 125             


Leu Phe Leu Ala Leu Phe Ala Val Lys Gly Met Glu Ala Ala Arg Ala 
    130                 135                 140                 


Cys Val Glu Ile Leu Ala Ala Arg Glu Lys Ile Ala Ala 
145                 150                 155         


<210>  41
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T32-28A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  41

Met Gly Glu Val Pro Ile Gly Asp Pro Lys Glu Leu Asn Gly Met Glu 
1               5                   10                  15      


Ile Ala Ala Val Tyr Leu Gln Pro Ile Glu Met Glu Pro Arg Gly Ile 
            20                  25                  30          


Asp Leu Ala Ala Ser Leu Ala Asp Ile His Leu Glu Ala Asp Ile His 
        35                  40                  45              


Ala Leu Lys Asn Asn Pro Asn Gly Phe Pro Glu Gly Phe Trp Met Pro 
    50                  55                  60                  


Tyr Leu Thr Ile Ala Tyr Ala Leu Ala Asn Ala Asp Thr Gly Ala Ile 
65                  70                  75                  80  


Lys Thr Gly Thr Leu Met Pro Met Val Ala Asp Asp Gly Pro His Tyr 
                85                  90                  95      


Gly Ala Asn Ile Ala Met Glu Lys Asp Lys Lys Gly Gly Phe Gly Val 
            100                 105                 110         


Gly Thr Tyr Ala Leu Thr Phe Leu Ile Ser Asn Pro Glu Lys Gln Gly 
        115                 120                 125             


Phe Gly Arg His Val Asp Glu Glu Thr Gly Val Gly Lys Trp Phe Glu 
    130                 135                 140                 


Pro Phe Val Val Thr Tyr Phe Phe Lys Tyr Thr Gly Thr Pro Lys 
145                 150                 155                 


<210>  42
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T32-28B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  42

Met Ser Gln Ala Ile Gly Ile Leu Glu Leu Thr Ser Ile Ala Lys Gly 
1               5                   10                  15      


Met Glu Leu Gly Asp Ala Met Leu Lys Ser Ala Asn Val Asp Leu Leu 
            20                  25                  30          


Val Ser Lys Thr Ile Ser Pro Gly Lys Phe Leu Leu Met Leu Gly Gly 
        35                  40                  45              


Asp Ile Gly Ala Ile Gln Gln Ala Ile Glu Thr Gly Thr Ser Gln Ala 
    50                  55                  60                  


Gly Glu Met Leu Val Asp Ser Leu Val Leu Ala Asn Ile His Pro Ser 
65                  70                  75                  80  


Val Leu Pro Ala Ile Ser Gly Leu Asn Ser Val Asp Lys Arg Gln Ala 
                85                  90                  95      


Val Gly Ile Val Glu Thr Trp Ser Val Ala Ala Cys Ile Ser Ala Ala 
            100                 105                 110         


Asp Leu Ala Val Lys Gly Ser Asn Val Thr Leu Val Arg Val His Met 
        115                 120                 125             


Ala Phe Gly Ile Gly Gly Lys Cys Tyr Met Val Val Ala Gly Asp Val 
    130                 135                 140                 


Leu Asp Val Ala Ala Ala Val Ala Thr Ala Ser Leu Ala Ala Gly Ala 
145                 150                 155                 160 


Lys Gly Leu Leu Val Tyr Ala Ser Ile Ile Pro Arg Pro His Glu Ala 
                165                 170                 175     


Met Trp Arg Gln Met Val Glu Gly 
            180                 


<210>  43
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T33-09A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  43

Met Glu Glu Val Val Leu Ile Thr Val Pro Ser Ala Leu Val Ala Val 
1               5                   10                  15      


Lys Ile Ala His Ala Leu Val Glu Glu Arg Leu Ala Ala Cys Val Asn 
            20                  25                  30          


Ile Val Pro Gly Leu Thr Ser Ile Tyr Arg Trp Gln Gly Ser Val Val 
        35                  40                  45              


Ser Asp His Glu Leu Leu Leu Leu Val Lys Thr Thr Thr His Ala Phe 
    50                  55                  60                  


Pro Lys Leu Lys Glu Arg Val Lys Ala Leu His Pro Tyr Thr Val Pro 
65                  70                  75                  80  


Glu Ile Val Ala Leu Pro Ile Ala Glu Gly Asn Arg Glu Tyr Leu Asp 
                85                  90                  95      


Trp Leu Arg Glu Asn Thr Gly 
            100             


<210>  44
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T33-09B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  44

Met Val Arg Gly Ile Arg Gly Ala Ile Thr Val Glu Glu Asp Thr Pro 
1               5                   10                  15      


Ala Ala Ile Leu Ala Ala Thr Ile Glu Leu Leu Leu Lys Met Leu Glu 
            20                  25                  30          


Ala Asn Gly Ile Gln Ser Tyr Glu Glu Leu Ala Ala Val Ile Phe Thr 
        35                  40                  45              


Val Thr Glu Asp Leu Thr Ser Ala Phe Pro Ala Glu Ala Ala Arg Leu 
    50                  55                  60                  


Ile Gly Met His Arg Val Pro Leu Leu Ser Ala Arg Glu Val Pro Val 
65                  70                  75                  80  


Pro Gly Ser Leu Pro Arg Val Ile Arg Val Leu Ala Leu Trp Asn Thr 
                85                  90                  95      


Asp Thr Pro Gln Asp Arg Val Arg His Val Tyr Leu Asn Glu Ala Val 
            100                 105                 110         


Arg Leu Arg Pro Asp Leu Glu Ser Ala Gln 
        115                 120         


<210>  45
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T33-15A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  45

Met Ser Lys Ala Lys Ile Gly Ile Val Thr Val Ser Asp Arg Ala Ser 
1               5                   10                  15      


Ala Gly Ile Thr Ala Asp Ile Ser Gly Lys Ala Ile Ile Leu Ala Leu 
            20                  25                  30          


Asn Leu Tyr Leu Thr Ser Glu Trp Glu Pro Ile Tyr Gln Val Ile Pro 
        35                  40                  45              


Asp Glu Gln Asp Val Ile Glu Thr Thr Leu Ile Lys Met Ala Asp Glu 
    50                  55                  60                  


Gln Asp Cys Cys Leu Ile Val Thr Thr Gly Gly Thr Gly Pro Ala Lys 
65                  70                  75                  80  


Arg Asp Val Thr Pro Glu Ala Thr Glu Ala Val Cys Asp Arg Met Met 
                85                  90                  95      


Pro Gly Phe Gly Glu Leu Met Arg Ala Glu Ser Leu Lys Glu Val Pro 
            100                 105                 110         


Thr Ala Ile Leu Ser Arg Gln Thr Ala Gly Leu Arg Gly Asp Ser Leu 
        115                 120                 125             


Ile Val Asn Leu Pro Gly Asp Pro Ala Ser Ile Ser Asp Cys Leu Leu 
    130                 135                 140                 


Ala Val Phe Pro Ala Ile Pro Tyr Cys Ile Asp Leu Met Glu Gly Pro 
145                 150                 155                 160 


Tyr Leu Glu Cys Asn Glu Ala Met Ile Lys Pro Phe Arg Pro Lys Ala 
                165                 170                 175     


Lys 
    


<210>  46
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T33-15B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  46

Met Val Arg Gly Ile Arg Gly Ala Ile Thr Val Asn Ser Asp Thr Pro 
1               5                   10                  15      


Thr Ser Ile Ile Ile Ala Thr Ile Leu Leu Leu Glu Lys Met Leu Glu 
            20                  25                  30          


Ala Asn Gly Ile Gln Ser Tyr Glu Glu Leu Ala Ala Val Ile Phe Thr 
        35                  40                  45              


Val Thr Glu Asp Leu Thr Ser Ala Phe Pro Ala Glu Ala Ala Arg Gln 
    50                  55                  60                  


Ile Gly Met His Arg Val Pro Leu Leu Ser Ala Arg Glu Val Pro Val 
65                  70                  75                  80  


Pro Gly Ser Leu Pro Arg Val Ile Arg Val Leu Ala Leu Trp Asn Thr 
                85                  90                  95      


Asp Thr Pro Gln Asp Arg Val Arg His Val Tyr Leu Ser Glu Ala Val 
            100                 105                 110         


Arg Leu Arg Pro Asp Leu Glu Ser Ala Gln 
        115                 120         


<210>  47
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T33-21A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  47

Met Arg Ile Thr Thr Lys Val Gly Asp Lys Gly Ser Thr Arg Leu Phe 
1               5                   10                  15      


Gly Gly Glu Glu Val Trp Lys Asp Ser Pro Ile Ile Glu Ala Asn Gly 
            20                  25                  30          


Thr Leu Asp Glu Leu Thr Ser Phe Ile Gly Glu Ala Lys His Tyr Val 
        35                  40                  45              


Asp Glu Glu Met Lys Gly Ile Leu Glu Glu Ile Gln Asn Asp Ile Tyr 
    50                  55                  60                  


Lys Ile Met Gly Glu Ile Gly Ser Lys Gly Lys Ile Glu Gly Ile Ser 
65                  70                  75                  80  


Glu Glu Arg Ile Ala Trp Leu Leu Lys Leu Ile Leu Arg Tyr Met Glu 
                85                  90                  95      


Met Val Asn Leu Lys Ser Phe Val Leu Pro Gly Gly Thr Leu Glu Ser 
            100                 105                 110         


Ala Lys Leu Asp Val Cys Arg Thr Ile Ala Arg Arg Ala Leu Arg Lys 
        115                 120                 125             


Val Leu Thr Val Thr Arg Glu Phe Gly Ile Gly Ala Glu Ala Ala Ala 
    130                 135                 140                 


Tyr Leu Leu Ala Leu Ser Asp Leu Leu Phe Leu Leu Ala Arg Val Ile 
145                 150                 155                 160 


Glu Ile Glu Lys Asn Lys Leu Lys Glu Val Arg Ser 
                165                 170         


<210>  48
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T33-21B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  48

Met Pro His Leu Val Ile Glu Ala Thr Ala Asn Leu Arg Leu Glu Thr 
1               5                   10                  15      


Ser Pro Gly Glu Leu Leu Glu Gln Ala Asn Lys Ala Leu Phe Ala Ser 
            20                  25                  30          


Gly Gln Phe Gly Glu Ala Asp Ile Lys Ser Arg Phe Val Thr Leu Glu 
        35                  40                  45              


Ala Tyr Arg Gln Gly Thr Ala Ala Val Glu Arg Ala Tyr Leu His Ala 
    50                  55                  60                  


Cys Leu Ser Ile Leu Asp Gly Arg Asp Ile Ala Thr Arg Thr Leu Leu 
65                  70                  75                  80  


Gly Ala Ser Leu Cys Ala Val Leu Ala Glu Ala Val Ala Gly Gly Gly 
                85                  90                  95      


Glu Glu Gly Val Gln Val Ser Val Glu Val Arg Glu Met Glu Arg Leu 
            100                 105                 110         


Ser Tyr Ala Lys Arg Val Val Ala Arg Gln Arg 
        115                 120             


<210>  49
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T33-28A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  49

Met Glu Ser Val Asn Thr Ser Phe Leu Ser Pro Ser Leu Val Thr Ile 
1               5                   10                  15      


Arg Asp Phe Asp Asn Gly Gln Phe Ala Val Leu Arg Ile Gly Arg Thr 
            20                  25                  30          


Gly Phe Pro Ala Asp Lys Gly Asp Ile Asp Leu Cys Leu Asp Lys Met 
        35                  40                  45              


Ile Gly Val Arg Ala Ala Gln Ile Phe Leu Gly Asp Asp Thr Glu Asp 
    50                  55                  60                  


Gly Phe Lys Gly Pro His Ile Arg Ile Arg Cys Val Asp Ile Asp Asp 
65                  70                  75                  80  


Lys His Thr Tyr Asn Ala Met Val Tyr Val Asp Leu Ile Val Gly Thr 
                85                  90                  95      


Gly Ala Ser Glu Val Glu Arg Glu Thr Ala Glu Glu Glu Ala Lys Leu 
            100                 105                 110         


Ala Leu Arg Val Ala Leu Gln Val Asp Ile Ala Asp Glu His Ser Cys 
        115                 120                 125             


Val Thr Gln Phe Glu Met Lys Leu Arg Glu Glu Leu Leu Ser Ser Asp 
    130                 135                 140                 


Ser Phe His Pro Asp Lys Asp Glu Tyr Tyr Lys Asp Phe Leu 
145                 150                 155             


<210>  50
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T33-28B


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  50

Met Pro Val Ile Gln Thr Phe Val Ser Thr Pro Leu Asp His His Lys 
1               5                   10                  15      


Arg Leu Leu Leu Ala Ile Ile Tyr Arg Ile Val Thr Arg Val Val Leu 
            20                  25                  30          


Gly Lys Pro Glu Asp Leu Val Met Met Thr Phe His Asp Ser Thr Pro 
        35                  40                  45              


Met His Phe Phe Gly Ser Thr Asp Pro Val Ala Cys Val Arg Val Glu 
    50                  55                  60                  


Ala Leu Gly Gly Tyr Gly Pro Ser Glu Pro Glu Lys Val Thr Ser Ile 
65                  70                  75                  80  


Val Thr Ala Ala Ile Thr Ala Val Cys Gly Ile Val Ala Asp Arg Ile 
                85                  90                  95      


Phe Val Leu Tyr Phe Ser Pro Leu His Cys Gly Trp Asn Gly Thr Asn 
            100                 105                 110         


Phe 
    


<210>  51
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T33-31A


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  optionally absent

<400>  51

Met Glu Glu Val Val Leu Ile Thr Val Pro Ser Ala Leu Val Ala Val 
1               5                   10                  15      


Lys Ile Ala His Ala Leu Val Glu Glu Arg Leu Ala Ala Cys Val Asn 
            20                  25                  30          


Ile Val Pro Gly Leu Thr Ser Ile Tyr Arg Glu Glu Gly Ser Val Val 
        35                  40                  45              


Ser Asp His Glu Leu Leu Leu Leu Val Lys Thr Thr Thr Asp Ala Phe 
    50                  55                  60                  


Pro Lys Leu Lys Glu Arg Val Lys Glu Leu His Pro Tyr Glu Val Pro 
65                  70                  75                  80  


Glu Ile Val Ala Leu Pro Ile Ala Glu Gly Asn Arg Glu Tyr Leu Asp 
                85                  90                  95      


Trp Leu Arg Glu Asn Thr Gly 
            100             


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  52

Gln Asn Ile Thr Glu Glu Phe 
1               5           


<210>  53
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (508)..(513)
<223>  optionally absent

<400>  53

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu 
    


<210>  54
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4 fibritin foldon domain

<400>  54

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  55

Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
1               5                   10                  15  


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  56

Gly Gly Ser Gly Gly Ser Gly Ser 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  57

Gly Ser Gly Gly Ser Gly Ser Gly 
1               5               


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Helical extension

<400>  58

Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg 
1               5                   10      


<210>  59
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  59

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly 
            20                  25  


<210>  60
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-foldon


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  60

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
        515                 520                 525             


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
    530                 535                 540 


<210>  61
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sc9-10 DS-Cav1 A149C Y458C


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (468)..(474)
<223>  optionally absent

<400>  61

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Gly Ser Gly Ser Ala Ile Cys Ser Gly 
            100                 105                 110         


Val Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile 
        115                 120                 125             


Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn 
    130                 135                 140                 


Gly Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile 
145                 150                 155                 160 


Asp Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser 
                165                 170                 175     


Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu 
            180                 185                 190         


Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val 
        195                 200                 205             


Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp 
    210                 215                 220                 


Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln 
225                 230                 235                 240 


Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu 
                245                 250                 255     


Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr 
            260                 265                 270         


Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys 
        275                 280                 285             


Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys 
    290                 295                 300                 


Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys 
305                 310                 315                 320 


Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu 
                325                 330                 335     


Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr 
            340                 345                 350         


Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile 
        355                 360                 365             


Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr 
    370                 375                 380                 


Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys 
385                 390                 395                 400 


Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr 
                405                 410                 415     


Leu Tyr Cys Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly 
            420                 425                 430         


Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu 
        435                 440                 445             


Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 
    450                 455                 460                 


Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 
465                 470                 


<210>  62
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sc9-10 DS-Cav1 A149C Y458C S46G K465Q S215P E92D


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (468)..(474)
<223>  optionally absent

<400>  62

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Gly Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Asp Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Gly Ser Gly Ser Ala Ile Cys Ser Gly 
            100                 105                 110         


Val Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile 
        115                 120                 125             


Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn 
    130                 135                 140                 


Gly Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile 
145                 150                 155                 160 


Asp Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Pro 
                165                 170                 175     


Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu 
            180                 185                 190         


Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val 
        195                 200                 205             


Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp 
    210                 215                 220                 


Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln 
225                 230                 235                 240 


Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu 
                245                 250                 255     


Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr 
            260                 265                 270         


Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys 
        275                 280                 285             


Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys 
    290                 295                 300                 


Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys 
305                 310                 315                 320 


Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu 
                325                 330                 335     


Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr 
            340                 345                 350         


Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile 
        355                 360                 365             


Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr 
    370                 375                 380                 


Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys 
385                 390                 395                 400 


Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr 
                405                 410                 415     


Leu Tyr Cys Val Asn Lys Gln Glu Gly Gln Ser Leu Tyr Val Lys Gly 
            420                 425                 430         


Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu 
        435                 440                 445             


Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 
    450                 455                 460                 


Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu 
465                 470                 


<210>  63
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC-DM (N67I, S215P)


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (486)..(522)
<223>  optionally absent

<400>  63

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Lys Ile Lys Cys Asn Gly Thr Asp Ala Lys Ile Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Gln Ala Arg Gly Ser Gly Ser 
            100                 105                 110         


Gly Arg Ser Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser 
        115                 120                 125             


Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 
    130                 135                 140                 


Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 
145                 150                 155                 160 


Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 
                165                 170                 175     


Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile 
            180                 185                 190         


Pro Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 
        195                 200                 205             


Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro 
    210                 215                 220                 


Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn 
225                 230                 235                 240 


Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val 
                245                 250                 255     


Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu 
            260                 265                 270         


Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp 
        275                 280                 285             


Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr 
    290                 295                 300                 


Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr 
305                 310                 315                 320 


Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys 
                325                 330                 335     


Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr 
            340                 345                 350         


Leu Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys 
        355                 360                 365             


Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val 
    370                 375                 380                 


Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys 
385                 390                 395                 400 


Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
                405                 410                 415     


Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn 
            420                 425                 430         


Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys 
        435                 440                 445             


Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 
465                 470                 475                 480 


Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Ala Ile Gly Gly 
                485                 490                 495     


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
            500                 505                 510         


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
        515                 520         


<210>  64
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC-TM (N67I, S215P, and E487Q)


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (486)..(522)
<223>  optionally absent

<400>  64

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Lys Ile Lys Cys Asn Gly Thr Asp Ala Lys Ile Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Gln Ala Arg Gly Ser Gly Ser 
            100                 105                 110         


Gly Arg Ser Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser 
        115                 120                 125             


Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 
    130                 135                 140                 


Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 
145                 150                 155                 160 


Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 
                165                 170                 175     


Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile 
            180                 185                 190         


Pro Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 
        195                 200                 205             


Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro 
    210                 215                 220                 


Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn 
225                 230                 235                 240 


Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val 
                245                 250                 255     


Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu 
            260                 265                 270         


Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp 
        275                 280                 285             


Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr 
    290                 295                 300                 


Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr 
305                 310                 315                 320 


Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys 
                325                 330                 335     


Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr 
            340                 345                 350         


Leu Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys 
        355                 360                 365             


Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val 
    370                 375                 380                 


Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys 
385                 390                 395                 400 


Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
                405                 410                 415     


Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn 
            420                 425                 430         


Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys 
        435                 440                 445             


Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


Gln Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 
465                 470                 475                 480 


Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Ser Ala Ile Gly Gly 
                485                 490                 495     


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
            500                 505                 510         


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
        515                 520         


<210>  65
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV F protein, strain CAN97-83 (A2)


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  65

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly 
                485                 490 


<210>  66
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPVF with A113C, A339C, T160F, I177L


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  66

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly 
                485                 490 


<210>  67
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV- F with A113C, A120C, A339C, T160F, I177L, and Q426C


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  67

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Cys Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Cys Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly 
                485                 490 


<210>  68
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  115-BV (A185P)


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (490)..(542)
<223>  optionally absent

<400>  68

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Ser Gly Arg Glu Asn Leu Tyr 
                485                 490                 495     


Phe Gln Gly Gly Gly Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp 
            500                 505                 510         


Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr 
        515                 520                 525             


Phe Leu Gly Gly Ile Glu Gly Arg His His His His His His 
    530                 535                 540         


<210>  69
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-foldon-T33-31A


<220>
<221>  MISC_FEATURE
<222>  (1)..(26)
<223>  optionally absent

<400>  69

Met Glu Leu Leu Ile Leu Lys Ala Asn Val Ile Ala Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
        515                 520                 525             


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Gly Ser Met 
    530                 535                 540                 


Glu Glu Val Val Leu Ile Thr Val Pro Ser Ala Leu Val Ala Val Lys 
545                 550                 555                 560 


Ile Ala His Ala Leu Val Glu Glu Arg Leu Ala Ala Cys Val Asn Ile 
                565                 570                 575     


Val Pro Gly Leu Thr Ser Ile Tyr Arg Glu Glu Gly Ser Val Val Ser 
            580                 585                 590         


Asp His Glu Leu Leu Leu Leu Val Lys Thr Thr Thr Asp Ala Phe Pro 
        595                 600                 605             


Lys Leu Lys Glu Arg Val Lys Glu Leu His Pro Tyr Glu Val Pro Glu 
    610                 615                 620                 


Ile Val Ala Leu Pro Ile Ala Glu Gly Asn Arg Glu Tyr Leu Asp Trp 
625                 630                 635                 640 


Leu Arg Glu Asn Thr Gly 
                645     


<210>  70
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-T33-31A


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  70

Met Glu Leu Leu Ile Leu Lys Ala Asn Val Ile Ala Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu Gly Gly Ser Met Glu Glu Val Val Leu Ile Thr Val Pro Ser Ala 
        515                 520                 525             


Leu Val Ala Val Lys Ile Ala His Ala Leu Val Glu Glu Arg Leu Ala 
    530                 535                 540                 


Ala Cys Val Asn Ile Val Pro Gly Leu Thr Ser Ile Tyr Arg Glu Glu 
545                 550                 555                 560 


Gly Ser Val Val Ser Asp His Glu Leu Leu Leu Leu Val Lys Thr Thr 
                565                 570                 575     


Thr Asp Ala Phe Pro Lys Leu Lys Glu Arg Val Lys Glu Leu His Pro 
            580                 585                 590         


Tyr Glu Val Pro Glu Ile Val Ala Leu Pro Ile Ala Glu Gly Asn Arg 
        595                 600                 605             


Glu Tyr Leu Asp Trp Leu Arg Glu Asn Thr Gly 
    610                 615                 


<210>  71
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-foldon-T33-15B


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  71

Met Glu Leu Leu Ile Leu Lys Ala Asn Val Ile Ala Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg 
        515                 520                 525             


Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Gly Ser Met 
    530                 535                 540                 


Val Arg Gly Ile Arg Gly Ala Ile Thr Val Asn Ser Asp Thr Pro Thr 
545                 550                 555                 560 


Ser Ile Ile Ile Ala Thr Ile Leu Leu Leu Glu Lys Met Leu Glu Ala 
                565                 570                 575     


Asn Gly Ile Gln Ser Tyr Glu Glu Leu Ala Ala Val Ile Phe Thr Val 
            580                 585                 590         


Thr Glu Asp Leu Thr Ser Ala Phe Pro Ala Glu Ala Ala Arg Gln Ile 
        595                 600                 605             


Gly Met His Arg Val Pro Leu Leu Ser Ala Arg Glu Val Pro Val Pro 
    610                 615                 620                 


Gly Ser Leu Pro Arg Val Ile Arg Val Leu Ala Leu Trp Asn Thr Asp 
625                 630                 635                 640 


Thr Pro Gln Asp Arg Val Arg His Val Tyr Leu Ser Glu Ala Val Arg 
                645                 650                 655     


Leu Arg Pro Asp Leu Glu Ser Ala Gln 
            660                 665 


<210>  72
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-T33-15B


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  72

Met Glu Leu Leu Ile Leu Lys Ala Asn Val Ile Ala Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu Gly Gly Ser Met Val Arg Gly Ile Arg Gly Ala Ile Thr Val Asn 
        515                 520                 525             


Ser Asp Thr Pro Thr Ser Ile Ile Ile Ala Thr Ile Leu Leu Leu Glu 
    530                 535                 540                 


Lys Met Leu Glu Ala Asn Gly Ile Gln Ser Tyr Glu Glu Leu Ala Ala 
545                 550                 555                 560 


Val Ile Phe Thr Val Thr Glu Asp Leu Thr Ser Ala Phe Pro Ala Glu 
                565                 570                 575     


Ala Ala Arg Gln Ile Gly Met His Arg Val Pro Leu Leu Ser Ala Arg 
            580                 585                 590         


Glu Val Pro Val Pro Gly Ser Leu Pro Arg Val Ile Arg Val Leu Ala 
        595                 600                 605             


Leu Trp Asn Thr Asp Thr Pro Gln Asp Arg Val Arg His Val Tyr Leu 
    610                 615                 620                 


Ser Glu Ala Val Arg Leu Arg Pro Asp Leu Glu Ser Ala Gln 
625                 630                 635             


<210>  73
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-foldon-I53-50A


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  73

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Gly Tyr Ile Pro Glu 
            500                 505                 510         


Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val 
        515                 520                 525             


Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser His His His His His His 
    530                 535                 540                 


His His Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys Ala Ala Lys Ala 
545                 550                 555                 560 


Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile 
                565                 570                 575     


Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala 
            580                 585                 590         


Val Ala Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr 
        595                 600                 605             


Val Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu 
    610                 615                 620                 


Lys Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys 
625                 630                 635                 640 


Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu 
                645                 650                 655     


Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met 
            660                 665                 670         


Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly 
        675                 680                 685             


His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe 
    690                 695                 700                 


Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr 
705                 710                 715                 720 


Gly Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val 
                725                 730                 735     


Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu 
            740                 745                 750         


Val Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr 
        755                 760                 765             


Glu 
    


<210>  74
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-I53-50A


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  74

Met Glu Leu Leu Ile Leu Lys Ala Asn Val Ile Ala Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Gly Gly Ser Gly Gly 
            500                 505                 510         


Ser Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met 
        515                 520                 525             


Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
    530                 535                 540                 


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
545                 550                 555                 560 


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
                565                 570                 575     


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
            580                 585                 590         


Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly 
        595                 600                 605             


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
    610                 615                 620                 


Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
625                 630                 635                 640 


Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe 
                645                 650                 655     


Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro 
            660                 665                 670         


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn 
        675                 680                 685             


Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser 
    690                 695                 700                 


Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala 
705                 710                 715                 720 


Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
                725                 730 


<210>  75
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-I32-28A


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  75

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         


Leu Gly Gly Ser Gly Gly Ser Gly Ser Asp Asp Ala Arg Ile Ala Ala 
        515                 520                 525             


Ile Gly Asp Val Asp Glu Leu Asn Ser Gln Ile Gly Val Leu Leu Ala 
    530                 535                 540                 


Glu Pro Leu Pro Asp Asp Val Arg Ala Ala Leu Ser Ala Ile Gln His 
545                 550                 555                 560 


Asp Leu Phe Asp Leu Gly Gly Glu Leu Cys Ile Pro Gly His Ala Ala 
                565                 570                 575     


Ile Thr Glu Asp His Leu Leu Arg Leu Ala Leu Trp Leu Val His Tyr 
            580                 585                 590         


Asn Gly Gln Leu Pro Pro Leu Glu Glu Phe Ile Leu Pro Gly Gly Ala 
        595                 600                 605             


Arg Gly Ala Ala Leu Ala His Val Cys Arg Thr Val Cys Arg Arg Ala 
    610                 615                 620                 


Glu Arg Ser Ile Lys Ala Leu Gly Ala Ser Glu Pro Leu Asn Ile Ala 
625                 630                 635                 640 


Pro Ala Ala Tyr Val Asn Leu Leu Ser Asp Leu Leu Phe Val Leu Ala 
                645                 650                 655     


Arg Val Leu Asn Arg Ala Ala Gly Gly Ala Asp Val Leu Trp Asp Arg 
            660                 665                 670         


Thr Arg Ala His 
        675     


<210>  76
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-8GS-HelExt-I53-50A (F10)


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  76

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Gly Ser Gly Gly Ser 
            500                 505                 510         


Gly Ser Gly Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met 
        515                 520                 525             


Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
    530                 535                 540                 


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
545                 550                 555                 560 


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
                565                 570                 575     


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
            580                 585                 590         


Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly 
        595                 600                 605             


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
    610                 615                 620                 


Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
625                 630                 635                 640 


Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe 
                645                 650                 655     


Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro 
            660                 665                 670         


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn 
        675                 680                 685             


Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser 
    690                 695                 700                 


Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala 
705                 710                 715                 720 


Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
                725                 730 


<210>  77
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-foldon-15GS-HelExt-I53-50A (F14)


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  77

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Gly Tyr Ile Pro Glu 
            500                 505                 510         


Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val 
        515                 520                 525             


Leu Leu Ser Thr Phe Leu Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly 
    530                 535                 540                 


Gly Ser Gly Ser Gly Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg 
545                 550                 555                 560 


Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg 
                565                 570                 575     


Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala 
            580                 585                 590         


Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp 
        595                 600                 605             


Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile 
    610                 615                 620                 


Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu 
625                 630                 635                 640 


Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser 
                645                 650                 655     


Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr 
            660                 665                 670         


Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys 
        675                 680                 685             


Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys 
    690                 695                 700                 


Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu 
705                 710                 715                 720 


Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val 
                725                 730                 735     


Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala 
            740                 745                 750         


Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
        755                 760                 


<210>  78
<211>  774
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV F wt_CAN97-83 strain-I53-50A


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  78

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Phe Ile Ile Val Ile Ile 
                485                 490                 495     


Leu Ile Ala Val Leu Gly Ser Ser Met Ile Leu Val Ser Ile Phe Ile 
            500                 505                 510         


Ile Ile Lys Lys Thr Lys Lys Pro Thr Gly Ala Pro Pro Glu Leu Ser 
        515                 520                 525             


Gly Val Thr Asn Asn Gly Phe Ile Pro His Ser Gly Ser Gly Ser His 
    530                 535                 540                 


His His His His His His His Gly Gly Ser Gly Gly Ser Gly Ser Glu 
545                 550                 555                 560 


Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe 
                565                 570                 575     


Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu 
            580                 585                 590         


Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val His Leu Ile 
        595                 600                 605             


Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile Lys Ala Leu 
    610                 615                 620                 


Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly Thr Val Thr 
625                 630                 635                 640 


Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile 
                645                 650                 655     


Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys 
            660                 665                 670         


Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys 
        675                 680                 685             


Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val 
    690                 695                 700                 


Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val 
705                 710                 715                 720 


Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val Cys Glu Trp 
                725                 730                 735     


Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys 
            740                 745                 750         


Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe Val Glu Lys 
        755                 760                 765             


Ile Arg Gly Cys Thr Glu 
    770                 


<210>  79
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV F A113C_A339C_T160F_I177L-I53-50A


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  79

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Gly Ser Gly Ser His His 
                485                 490                 495     


His His His His His His Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys 
            500                 505                 510         


Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys 
        515                 520                 525             


Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala 
    530                 535                 540                 


Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val His Leu Ile Glu 
545                 550                 555                 560 


Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser 
                565                 570                 575     


Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser 
            580                 585                 590         


Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val 
        595                 600                 605             


Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly 
    610                 615                 620                 


Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala 
625                 630                 635                 640 


Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val 
                645                 650                 655     


Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys 
            660                 665                 670         


Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe 
        675                 680                 685             


Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly 
    690                 695                 700                 


Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile 
705                 710                 715                 720 


Arg Gly Cys Thr Glu 
                725 


<210>  80
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV F A113C_A339C_T160F_I177L_A120C, Q426C - I53-50A


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  80

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Cys Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Cys Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Gly Ser Gly Ser His His 
                485                 490                 495     


His His His His His His Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys 
            500                 505                 510         


Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys 
        515                 520                 525             


Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala 
    530                 535                 540                 


Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val His Leu Ile Glu 
545                 550                 555                 560 


Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser 
                565                 570                 575     


Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser 
            580                 585                 590         


Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val 
        595                 600                 605             


Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly 
    610                 615                 620                 


Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala 
625                 630                 635                 640 


Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val 
                645                 650                 655     


Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys 
            660                 665                 670         


Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe 
        675                 680                 685             


Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly 
    690                 695                 700                 


Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile 
705                 710                 715                 720 


Arg Gly Cys Thr Glu 
                725 


<210>  81
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sc-DS2-I53-50A


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  81

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Gly Ser Gly Ser Cys Ile Ala Ser Gly 
            100                 105                 110         


Val Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile 
        115                 120                 125             


Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn 
    130                 135                 140                 


Gly Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile 
145                 150                 155                 160 


Asp Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser 
                165                 170                 175     


Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu 
            180                 185                 190         


Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val 
        195                 200                 205             


Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp 
    210                 215                 220                 


Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln 
225                 230                 235                 240 


Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu 
                245                 250                 255     


Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr 
            260                 265                 270         


Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys 
        275                 280                 285             


Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys 
    290                 295                 300                 


Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys 
305                 310                 315                 320 


Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr Leu 
                325                 330                 335     


Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr 
            340                 345                 350         


Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile 
        355                 360                 365             


Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr 
    370                 375                 380                 


Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys 
385                 390                 395                 400 


Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr 
                405                 410                 415     


Leu Tyr Cys Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly 
            420                 425                 430         


Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu 
        435                 440                 445             


Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 
    450                 455                 460                 


Ala Phe Ile Arg Gly Ser Gly Ser His His His His His His His His 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu 
                485                 490                 495     


Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala 
            500                 505                 510         


Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala 
        515                 520                 525             


Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro 
    530                 535                 540                 


Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly 
545                 550                 555                 560 


Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys 
                565                 570                 575     


Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu 
            580                 585                 590         


Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly 
        595                 600                 605             


Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr 
    610                 615                 620                 


Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys 
625                 630                 635                 640 


Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly 
                645                 650                 655     


Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala 
            660                 665                 670         


Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg 
        675                 680                 685             


Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
    690                 695                 700             


<210>  82
<211>  742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tc-DS2-I53-50A


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  82

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Cys Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Cys Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Gly Ser Gly Ser His 
            500                 505                 510         


His His His His His His His Gly Gly Ser Gly Gly Ser Gly Ser Glu 
        515                 520                 525             


Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe 
    530                 535                 540                 


Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu 
545                 550                 555                 560 


Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val His Leu Ile 
                565                 570                 575     


Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile Lys Ala Leu 
            580                 585                 590         


Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly Thr Val Thr 
        595                 600                 605             


Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile 
    610                 615                 620                 


Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys 
625                 630                 635                 640 


Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys 
                645                 650                 655     


Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val 
            660                 665                 670         


Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val 
        675                 680                 685             


Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val Cys Glu Trp 
    690                 695                 700                 


Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys 
705                 710                 715                 720 


Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe Val Glu Lys 
                725                 730                 735     


Ile Arg Gly Cys Thr Glu 
            740         


<210>  83
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-12GS-HelExt-I53-50A (F11)


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  83

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Gly Ser Gly Gly Ser 
            500                 505                 510         


Gly Ser Gly Ser Gly Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu Ala 
        515                 520                 525             


Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val 
    530                 535                 540                 


Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val 
545                 550                 555                 560 


Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp 
                565                 570                 575     


Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala 
            580                 585                 590         


Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala 
        595                 600                 605             


Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu 
    610                 615                 620                 


Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val 
625                 630                 635                 640 


Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile 
                645                 650                 655     


Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala 
            660                 665                 670         


Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val 
        675                 680                 685             


Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val 
    690                 695                 700                 


Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu 
705                 710                 715                 720 


Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
                725                 730                 


<210>  84
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-16GS-HelExt-I53-50A (F12)


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  84

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Gly Ser Gly Gly Ser 
            500                 505                 510         


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Glu Lys Ala Ala Lys 
        515                 520                 525             


Ala Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys 
    530                 535                 540                 


Ile Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys 
545                 550                 555                 560 


Ala Val Ala Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe 
                565                 570                 575     


Thr Val Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys 
            580                 585                 590         


Glu Lys Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln 
        595                 600                 605             


Cys Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His 
    610                 615                 620                 


Leu Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr 
625                 630                 635                 640 


Met Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu 
                645                 650                 655     


Gly His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln 
            660                 665                 670         


Phe Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro 
        675                 680                 685             


Thr Gly Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly 
    690                 695                 700                 


Val Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp 
705                 710                 715                 720 


Glu Val Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys 
                725                 730                 735     


Thr Glu 
        


<210>  85
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-foldon-10GS-HelExt-I53-50A (F13)


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  85

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Gly Tyr Ile Pro Glu 
            500                 505                 510         


Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val 
        515                 520                 525             


Leu Leu Ser Thr Phe Leu Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly 
    530                 535                 540                 


Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu Glu Leu 
545                 550                 555                 560 


Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser Val Glu 
                565                 570                 575     


Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val His Leu 
            580                 585                 590         


Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile Lys Ala 
        595                 600                 605             


Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly Thr Val 
    610                 615                 620                 


Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala Glu Phe 
625                 630                 635                 640 


Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu 
                645                 650                 655     


Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu Leu Val 
            660                 665                 670         


Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro Gly Glu 
        675                 680                 685             


Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe Pro Asn 
    690                 695                 700                 


Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val Cys Glu 
705                 710                 715                 720 


Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala Leu Val 
                725                 730                 735     


Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe Val Glu 
            740                 745                 750         


Lys Ile Arg Gly Cys Thr Glu 
        755                 


<210>  86
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS-Cav1-foldon-20GS-HelExt-I53-50A (F15)


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<400>  86

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         


Arg Phe Met Asn Tyr Thr Leu Asn Asn Ala Lys Lys Thr Asn Val Thr 
        115                 120                 125             


Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 


Gly Ser Ala Ile Ala Ser Gly Val Ala Val Cys Lys Val Leu His Leu 
145                 150                 155                 160 


Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     


Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Phe Lys Val 
            180                 185                 190         


Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Leu Asn 
        195                 200                 205             


Lys Gln Ser Cys Ser Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 


Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 


Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     


Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         


Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             


Met Cys Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 


Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 


Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     


Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         


Pro Gln Ala Glu Thr Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             


Thr Met Asn Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 


Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 


Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     


Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         


Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             


Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 


Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 


Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     


Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Gly Tyr Ile Pro Glu 
            500                 505                 510         


Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val 
        515                 520                 525             


Leu Leu Ser Thr Phe Leu Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly 
    530                 535                 540                 


Gly Ser Gly Ser Gly Gly Ser Ser Gly Ser Glu Lys Ala Ala Lys Ala 
545                 550                 555                 560 


Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile 
                565                 570                 575     


Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala 
            580                 585                 590         


Val Ala Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr 
        595                 600                 605             


Val Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu 
    610                 615                 620                 


Lys Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys 
625                 630                 635                 640 


Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu 
                645                 650                 655     


Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met 
            660                 665                 670         


Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly 
        675                 680                 685             


His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe 
    690                 695                 700                 


Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr 
705                 710                 715                 720 


Gly Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val 
                725                 730                 735     


Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu 
            740                 745                 750         


Val Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr 
        755                 760                 765             


Glu 
    


<210>  87
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sc9-10 DS-Cav1 A149C Y458C-foldon-I53-50A embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (469)..(474)
<223>  optionally absent

<400>  87

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Gly Ser Gly Ser Ala Ile Cys Ser Gly 
            100                 105                 110         


Val Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile 
        115                 120                 125             


Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn 
    130                 135                 140                 


Gly Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile 
145                 150                 155                 160 


Asp Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser 
                165                 170                 175     


Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu 
            180                 185                 190         


Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val 
        195                 200                 205             


Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp 
    210                 215                 220                 


Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln 
225                 230                 235                 240 


Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu 
                245                 250                 255     


Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr 
            260                 265                 270         


Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys 
        275                 280                 285             


Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys 
    290                 295                 300                 


Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys 
305                 310                 315                 320 


Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu 
                325                 330                 335     


Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr 
            340                 345                 350         


Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile 
        355                 360                 365             


Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr 
    370                 375                 380                 


Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys 
385                 390                 395                 400 


Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr 
                405                 410                 415     


Leu Tyr Cys Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly 
            420                 425                 430         


Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu 
        435                 440                 445             


Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 
    450                 455                 460                 


Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Tyr Ile Pro Glu Ala 
465                 470                 475                 480 


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
                485                 490                 495     


Leu Ser Thr Phe Leu Gly Ser Gly Ser His His His His His His His 
            500                 505                 510         


His Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys Ala Ala Lys Ala Glu 
        515                 520                 525             


Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val 
    530                 535                 540                 


Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val 
545                 550                 555                 560 


Ala Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val 
                565                 570                 575     


Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys 
            580                 585                 590         


Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg 
        595                 600                 605             


Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp 
    610                 615                 620                 


Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro 
625                 630                 635                 640 


Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His 
                645                 650                 655     


Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val 
            660                 665                 670         


Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly 
        675                 680                 685             


Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu 
    690                 695                 700                 


Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val 
705                 710                 715                 720 


Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
                725                 730                 735     


<210>  88
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sc9-10 DS-Cav1 A149C Y458C - F10 embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (469)..(474)
<223>  optionally absent

<400>  88

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Gly Ser Gly Ser Ala Ile Cys Ser Gly 
            100                 105                 110         


Val Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile 
        115                 120                 125             


Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn 
    130                 135                 140                 


Gly Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile 
145                 150                 155                 160 


Asp Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Ser 
                165                 170                 175     


Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu 
            180                 185                 190         


Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val 
        195                 200                 205             


Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp 
    210                 215                 220                 


Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln 
225                 230                 235                 240 


Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu 
                245                 250                 255     


Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr 
            260                 265                 270         


Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys 
        275                 280                 285             


Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys 
    290                 295                 300                 


Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys 
305                 310                 315                 320 


Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu 
                325                 330                 335     


Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr 
            340                 345                 350         


Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile 
        355                 360                 365             


Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr 
    370                 375                 380                 


Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys 
385                 390                 395                 400 


Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr 
                405                 410                 415     


Leu Tyr Cys Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys Gly 
            420                 425                 430         


Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu 
        435                 440                 445             


Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 
    450                 455                 460                 


Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Ser Gly Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu 
                485                 490                 495     


Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser 
            500                 505                 510         


Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val 
        515                 520                 525             


His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile 
    530                 535                 540                 


Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly 
545                 550                 555                 560 


Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala 
                565                 570                 575     


Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys 
            580                 585                 590         


Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu 
        595                 600                 605             


Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro 
    610                 615                 620                 


Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe 
625                 630                 635                 640 


Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val 
                645                 650                 655     


Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala 
            660                 665                 670         


Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe 
        675                 680                 685             


Val Glu Lys Ile Arg Gly Cys Thr Glu 
    690                 695         


<210>  89
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sc9-10 DS-Cav1 A149C Y458C S46G K465Q S215P E92D -foldon-I53-50A 
       embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (469)..(474)
<223>  optionally absent

<400>  89

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Gly Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Asp Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Gly Ser Gly Ser Ala Ile Cys Ser Gly 
            100                 105                 110         


Val Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile 
        115                 120                 125             


Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn 
    130                 135                 140                 


Gly Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile 
145                 150                 155                 160 


Asp Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Pro 
                165                 170                 175     


Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu 
            180                 185                 190         


Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val 
        195                 200                 205             


Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp 
    210                 215                 220                 


Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln 
225                 230                 235                 240 


Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu 
                245                 250                 255     


Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr 
            260                 265                 270         


Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys 
        275                 280                 285             


Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys 
    290                 295                 300                 


Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys 
305                 310                 315                 320 


Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu 
                325                 330                 335     


Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr 
            340                 345                 350         


Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile 
        355                 360                 365             


Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr 
    370                 375                 380                 


Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys 
385                 390                 395                 400 


Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr 
                405                 410                 415     


Leu Tyr Cys Val Asn Lys Gln Glu Gly Gln Ser Leu Tyr Val Lys Gly 
            420                 425                 430         


Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu 
        435                 440                 445             


Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 
    450                 455                 460                 


Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Tyr Ile Pro Glu Ala 
465                 470                 475                 480 


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
                485                 490                 495     


Leu Ser Thr Phe Leu Gly Ser Gly Ser His His His His His His His 
            500                 505                 510         


His Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys Ala Ala Lys Ala Glu 
        515                 520                 525             


Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val 
    530                 535                 540                 


Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val 
545                 550                 555                 560 


Ala Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val 
                565                 570                 575     


Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys 
            580                 585                 590         


Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg 
        595                 600                 605             


Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp 
    610                 615                 620                 


Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro 
625                 630                 635                 640 


Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His 
                645                 650                 655     


Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val 
            660                 665                 670         


Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly 
        675                 680                 685             


Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu 
    690                 695                 700                 


Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val 
705                 710                 715                 720 


Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
                725                 730                 735     


<210>  90
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sc9-10 DS-Cav1 A149C Y458C S46G K465Q S215P E92D - F10 embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (469)..(474)
<223>  optionally absent

<400>  90

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Gly Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Asp Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Gly Ser Gly Ser Ala Ile Cys Ser Gly 
            100                 105                 110         


Val Ala Val Cys Lys Val Leu His Leu Glu Gly Glu Val Asn Lys Ile 
        115                 120                 125             


Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser Asn 
    130                 135                 140                 


Gly Val Ser Val Leu Thr Phe Lys Val Leu Asp Leu Lys Asn Tyr Ile 
145                 150                 155                 160 


Asp Lys Gln Leu Leu Pro Ile Leu Asn Lys Gln Ser Cys Ser Ile Pro 
                165                 170                 175     


Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu Leu 
            180                 185                 190         


Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro Val 
        195                 200                 205             


Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp 
    210                 215                 220                 


Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val Gln 
225                 230                 235                 240 


Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Cys Ile Ile Lys Glu Glu 
                245                 250                 255     


Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp Thr 
            260                 265                 270         


Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr Lys 
        275                 280                 285             


Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr Cys 
    290                 295                 300                 


Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys Lys 
305                 310                 315                 320 


Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Arg Thr Leu 
                325                 330                 335     


Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys Tyr 
            340                 345                 350         


Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val Ile 
        355                 360                 365             


Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys Thr 
    370                 375                 380                 


Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly Cys 
385                 390                 395                 400 


Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn Thr 
                405                 410                 415     


Leu Tyr Cys Val Asn Lys Gln Glu Gly Gln Ser Leu Tyr Val Lys Gly 
            420                 425                 430         


Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp Glu 
        435                 440                 445             


Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser Leu 
    450                 455                 460                 


Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Ser Gly Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu 
                485                 490                 495     


Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser 
            500                 505                 510         


Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val 
        515                 520                 525             


His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile 
    530                 535                 540                 


Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly 
545                 550                 555                 560 


Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala 
                565                 570                 575     


Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys 
            580                 585                 590         


Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu 
        595                 600                 605             


Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro 
    610                 615                 620                 


Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe 
625                 630                 635                 640 


Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val 
                645                 650                 655     


Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala 
            660                 665                 670         


Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe 
        675                 680                 685             


Val Glu Lys Ile Arg Gly Cys Thr Glu 
    690                 695         


<210>  91
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC-DM (N67I, S215P) - foldon-I53-50A embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (486)..(491)
<223>  optionally absent

<400>  91

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Lys Ile Lys Cys Asn Gly Thr Asp Ala Lys Ile Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Gln Ala Arg Gly Ser Gly Ser 
            100                 105                 110         


Gly Arg Ser Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser 
        115                 120                 125             


Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 
    130                 135                 140                 


Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 
145                 150                 155                 160 


Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 
                165                 170                 175     


Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile 
            180                 185                 190         


Pro Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 
        195                 200                 205             


Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro 
    210                 215                 220                 


Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn 
225                 230                 235                 240 


Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val 
                245                 250                 255     


Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu 
            260                 265                 270         


Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp 
        275                 280                 285             


Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr 
    290                 295                 300                 


Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr 
305                 310                 315                 320 


Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys 
                325                 330                 335     


Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr 
            340                 345                 350         


Leu Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys 
        355                 360                 365             


Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val 
    370                 375                 380                 


Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys 
385                 390                 395                 400 


Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
                405                 410                 415     


Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn 
            420                 425                 430         


Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys 
        435                 440                 445             


Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 
465                 470                 475                 480 


Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Tyr Ile Pro Glu 
                485                 490                 495     


Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val 
            500                 505                 510         


Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser His His His His His His 
        515                 520                 525             


His His Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys Ala Ala Lys Ala 
    530                 535                 540                 


Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile 
545                 550                 555                 560 


Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala 
                565                 570                 575     


Val Ala Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr 
            580                 585                 590         


Val Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu 
        595                 600                 605             


Lys Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys 
    610                 615                 620                 


Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu 
625                 630                 635                 640 


Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met 
                645                 650                 655     


Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly 
            660                 665                 670         


His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe 
        675                 680                 685             


Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr 
    690                 695                 700                 


Gly Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val 
705                 710                 715                 720 


Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu 
                725                 730                 735     


Val Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr 
            740                 745                 750         


Glu 
    


<210>  92
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC-DM (N67I, S215P) - F10 embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (486)..(491)
<223>  optionally absent

<400>  92

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Lys Ile Lys Cys Asn Gly Thr Asp Ala Lys Ile Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Gln Ala Arg Gly Ser Gly Ser 
            100                 105                 110         


Gly Arg Ser Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser 
        115                 120                 125             


Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 
    130                 135                 140                 


Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 
145                 150                 155                 160 


Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 
                165                 170                 175     


Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile 
            180                 185                 190         


Pro Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 
        195                 200                 205             


Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro 
    210                 215                 220                 


Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn 
225                 230                 235                 240 


Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val 
                245                 250                 255     


Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu 
            260                 265                 270         


Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp 
        275                 280                 285             


Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr 
    290                 295                 300                 


Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr 
305                 310                 315                 320 


Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys 
                325                 330                 335     


Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr 
            340                 345                 350         


Leu Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys 
        355                 360                 365             


Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val 
    370                 375                 380                 


Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys 
385                 390                 395                 400 


Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
                405                 410                 415     


Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn 
            420                 425                 430         


Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys 
        435                 440                 445             


Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 
465                 470                 475                 480 


Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Ser Gly Gly Ser 
                485                 490                 495     


Gly Ser Gly Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met 
            500                 505                 510         


Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
        515                 520                 525             


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
    530                 535                 540                 


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
545                 550                 555                 560 


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
                565                 570                 575     


Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly 
            580                 585                 590         


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
        595                 600                 605             


Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
    610                 615                 620                 


Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe 
625                 630                 635                 640 


Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro 
                645                 650                 655     


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn 
            660                 665                 670         


Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser 
        675                 680                 685             


Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala 
    690                 695                 700                 


Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
705                 710                 


<210>  93
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC-TM (N67I, S215P, and E487Q) - foldon-I53-50A embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (486)..(491)
<223>  optionally absent

<400>  93

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Lys Ile Lys Cys Asn Gly Thr Asp Ala Lys Ile Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Gln Ala Arg Gly Ser Gly Ser 
            100                 105                 110         


Gly Arg Ser Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser 
        115                 120                 125             


Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 
    130                 135                 140                 


Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 
145                 150                 155                 160 


Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 
                165                 170                 175     


Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile 
            180                 185                 190         


Pro Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 
        195                 200                 205             


Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro 
    210                 215                 220                 


Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn 
225                 230                 235                 240 


Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val 
                245                 250                 255     


Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu 
            260                 265                 270         


Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp 
        275                 280                 285             


Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr 
    290                 295                 300                 


Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr 
305                 310                 315                 320 


Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys 
                325                 330                 335     


Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr 
            340                 345                 350         


Leu Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys 
        355                 360                 365             


Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val 
    370                 375                 380                 


Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys 
385                 390                 395                 400 


Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
                405                 410                 415     


Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn 
            420                 425                 430         


Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys 
        435                 440                 445             


Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


Gln Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 
465                 470                 475                 480 


Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Tyr Ile Pro Glu 
                485                 490                 495     


Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val 
            500                 505                 510         


Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser His His His His His His 
        515                 520                 525             


His His Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys Ala Ala Lys Ala 
    530                 535                 540                 


Glu Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile 
545                 550                 555                 560 


Val Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala 
                565                 570                 575     


Val Ala Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr 
            580                 585                 590         


Val Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu 
        595                 600                 605             


Lys Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys 
    610                 615                 620                 


Arg Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu 
625                 630                 635                 640 


Asp Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met 
                645                 650                 655     


Pro Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly 
            660                 665                 670         


His Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe 
        675                 680                 685             


Val Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr 
    690                 695                 700                 


Gly Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val 
705                 710                 715                 720 


Leu Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu 
                725                 730                 735     


Val Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr 
            740                 745                 750         


Glu 
    


<210>  94
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SC-TM (N67I, S215P, and E487Q)-I53-50A - F10 embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(25)
<223>  optionally absent

<220>
<221>  MISC_FEATURE
<222>  (486)..(491)
<223>  optionally absent

<400>  94

Met Glu Leu Leu Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Thr 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Gly Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Lys Ile Lys Cys Asn Gly Thr Asp Ala Lys Ile Lys Leu Ile Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Thr Asn Asn Gln Ala Arg Gly Ser Gly Ser 
            100                 105                 110         


Gly Arg Ser Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser 
        115                 120                 125             


Gly Val Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 
    130                 135                 140                 


Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 
145                 150                 155                 160 


Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 
                165                 170                 175     


Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Ser Ile 
            180                 185                 190         


Pro Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 
        195                 200                 205             


Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Ala Gly Val Thr Thr Pro 
    210                 215                 220                 


Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn 
225                 230                 235                 240 


Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val 
                245                 250                 255     


Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu 
            260                 265                 270         


Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp 
        275                 280                 285             


Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr 
    290                 295                 300                 


Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr 
305                 310                 315                 320 


Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys 
                325                 330                 335     


Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr 
            340                 345                 350         


Leu Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys 
        355                 360                 365             


Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val 
    370                 375                 380                 


Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys 
385                 390                 395                 400 


Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
                405                 410                 415     


Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn 
            420                 425                 430         


Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys 
        435                 440                 445             


Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


Gln Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 
465                 470                 475                 480 


Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Ser Gly Gly Ser 
                485                 490                 495     


Gly Ser Gly Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met 
            500                 505                 510         


Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn 
        515                 520                 525             


Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly 
    530                 535                 540                 


Val His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val 
545                 550                 555                 560 


Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala 
                565                 570                 575     


Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly 
            580                 585                 590         


Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe 
        595                 600                 605             


Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr 
    610                 615                 620                 


Glu Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe 
625                 630                 635                 640 


Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro 
                645                 650                 655     


Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn 
            660                 665                 670         


Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser 
        675                 680                 685             


Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala 
    690                 695                 700                 


Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
705                 710                 


<210>  95
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV-F with A113C, A339C, T160F, I177L - foldon-I53-50A 
       embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  95

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Gly Tyr Ile Pro Glu Ala 
                485                 490                 495     


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
            500                 505                 510         


Leu Ser Thr Phe Leu Gly Ser Gly Ser His His His His His His His 
        515                 520                 525             


His Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys Ala Ala Lys Ala Glu 
    530                 535                 540                 


Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val 
545                 550                 555                 560 


Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val 
                565                 570                 575     


Ala Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val 
            580                 585                 590         


Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys 
        595                 600                 605             


Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg 
    610                 615                 620                 


Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp 
625                 630                 635                 640 


Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro 
                645                 650                 655     


Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His 
            660                 665                 670         


Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val 
        675                 680                 685             


Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly 
    690                 695                 700                 


Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu 
705                 710                 715                 720 


Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val 
                725                 730                 735     


Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
            740                 745                 750         


<210>  96
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV-F with A113C, A339C, T160F, I177L-I53-50A  F10 embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  96

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Gly Ser Gly Gly Ser Gly 
                485                 490                 495     


Ser Gly Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu 
            500                 505                 510         


Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser 
        515                 520                 525             


Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val 
    530                 535                 540                 


His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile 
545                 550                 555                 560 


Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly 
                565                 570                 575     


Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala 
            580                 585                 590         


Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys 
        595                 600                 605             


Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu 
    610                 615                 620                 


Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro 
625                 630                 635                 640 


Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe 
                645                 650                 655     


Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val 
            660                 665                 670         


Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala 
        675                 680                 685             


Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe 
    690                 695                 700                 


Val Glu Lys Ile Arg Gly Cys Thr Glu 
705                 710             


<210>  97
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV-F with A113C, A120C, A339C, T160F, I177L, and Q426C - 
       foldon-I53-50A embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  97

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Cys Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Cys Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Gly Tyr Ile Pro Glu Ala 
                485                 490                 495     


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
            500                 505                 510         


Leu Ser Thr Phe Leu Gly Ser Gly Ser His His His His His His His 
        515                 520                 525             


His Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys Ala Ala Lys Ala Glu 
    530                 535                 540                 


Glu Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val 
545                 550                 555                 560 


Ala Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val 
                565                 570                 575     


Ala Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val 
            580                 585                 590         


Pro Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys 
        595                 600                 605             


Gly Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg 
    610                 615                 620                 


Lys Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp 
625                 630                 635                 640 


Glu Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro 
                645                 650                 655     


Gly Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His 
            660                 665                 670         


Thr Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val 
        675                 680                 685             


Lys Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly 
    690                 695                 700                 


Gly Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu 
705                 710                 715                 720 


Ala Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val 
                725                 730                 735     


Arg Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
            740                 745                 750         


<210>  98
<211>  713
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV-F with A113C, A120C, A339C, T160F, I177L, and Q426C - F10 
       embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  98

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ser Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Cys Thr Ala Ala Ala Val Thr Cys Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Thr Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Phe 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Leu Asn Lys Asn Lys Cys Asp Ile Asp Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Cys Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Cys Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Ile Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Asn Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Gly Ser Gly Gly Ser Gly 
                485                 490                 495     


Ser Gly Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu 
            500                 505                 510         


Glu Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser 
        515                 520                 525             


Val Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val 
    530                 535                 540                 


His Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile 
545                 550                 555                 560 


Lys Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly 
                565                 570                 575     


Thr Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala 
            580                 585                 590         


Glu Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys 
        595                 600                 605             


Lys Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu 
    610                 615                 620                 


Leu Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro 
625                 630                 635                 640 


Gly Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe 
                645                 650                 655     


Pro Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val 
            660                 665                 670         


Cys Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala 
        675                 680                 685             


Leu Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe 
    690                 695                 700                 


Val Glu Lys Ile Arg Gly Cys Thr Glu 
705                 710             


<210>  99
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV-F 115-BV (A185P) -foldon-I53-50A embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  99

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Tyr Ile Pro Glu Ala Pro 
                485                 490                 495     


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
            500                 505                 510         


Ser Thr Phe Leu Gly Ser Gly Ser His His His His His His His His 
        515                 520                 525             


Gly Gly Ser Gly Gly Ser Gly Ser Glu Lys Ala Ala Lys Ala Glu Glu 
    530                 535                 540                 


Ala Ala Arg Lys Met Glu Glu Leu Phe Lys Lys His Lys Ile Val Ala 
545                 550                 555                 560 


Val Leu Arg Ala Asn Ser Val Glu Glu Ala Ile Glu Lys Ala Val Ala 
                565                 570                 575     


Val Phe Ala Gly Gly Val His Leu Ile Glu Ile Thr Phe Thr Val Pro 
            580                 585                 590         


Asp Ala Asp Thr Val Ile Lys Ala Leu Ser Val Leu Lys Glu Lys Gly 
        595                 600                 605             


Ala Ile Ile Gly Ala Gly Thr Val Thr Ser Val Glu Gln Cys Arg Lys 
    610                 615                 620                 


Ala Val Glu Ser Gly Ala Glu Phe Ile Val Ser Pro His Leu Asp Glu 
625                 630                 635                 640 


Glu Ile Ser Gln Phe Cys Lys Glu Lys Gly Val Phe Tyr Met Pro Gly 
                645                 650                 655     


Val Met Thr Pro Thr Glu Leu Val Lys Ala Met Lys Leu Gly His Thr 
            660                 665                 670         


Ile Leu Lys Leu Phe Pro Gly Glu Val Val Gly Pro Gln Phe Val Lys 
        675                 680                 685             


Ala Met Lys Gly Pro Phe Pro Asn Val Lys Phe Val Pro Thr Gly Gly 
    690                 695                 700                 


Val Asn Leu Asp Asn Val Cys Glu Trp Phe Lys Ala Gly Val Leu Ala 
705                 710                 715                 720 


Val Gly Val Gly Ser Ala Leu Val Lys Gly Thr Pro Asp Glu Val Arg 
                725                 730                 735     


Glu Lys Ala Lys Ala Phe Val Glu Lys Ile Arg Gly Cys Thr Glu 
            740                 745                 750     


<210>  100
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV-F 115-BV (A185P)-I53-50A - F10 embodiment


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  100

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Arg Arg Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Pro Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Ile Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Glu Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly Ser Gly Gly Ser Gly Ser 
                485                 490                 495     


Gly Glu Lys Ala Ala Lys Ala Glu Glu Ala Ala Arg Lys Met Glu Glu 
            500                 505                 510         


Leu Phe Lys Lys His Lys Ile Val Ala Val Leu Arg Ala Asn Ser Val 
        515                 520                 525             


Glu Glu Ala Ile Glu Lys Ala Val Ala Val Phe Ala Gly Gly Val His 
    530                 535                 540                 


Leu Ile Glu Ile Thr Phe Thr Val Pro Asp Ala Asp Thr Val Ile Lys 
545                 550                 555                 560 


Ala Leu Ser Val Leu Lys Glu Lys Gly Ala Ile Ile Gly Ala Gly Thr 
                565                 570                 575     


Val Thr Ser Val Glu Gln Cys Arg Lys Ala Val Glu Ser Gly Ala Glu 
            580                 585                 590         


Phe Ile Val Ser Pro His Leu Asp Glu Glu Ile Ser Gln Phe Cys Lys 
        595                 600                 605             


Glu Lys Gly Val Phe Tyr Met Pro Gly Val Met Thr Pro Thr Glu Leu 
    610                 615                 620                 


Val Lys Ala Met Lys Leu Gly His Thr Ile Leu Lys Leu Phe Pro Gly 
625                 630                 635                 640 


Glu Val Val Gly Pro Gln Phe Val Lys Ala Met Lys Gly Pro Phe Pro 
                645                 650                 655     


Asn Val Lys Phe Val Pro Thr Gly Gly Val Asn Leu Asp Asn Val Cys 
            660                 665                 670         


Glu Trp Phe Lys Ala Gly Val Leu Ala Val Gly Val Gly Ser Ala Leu 
        675                 680                 685             


Val Lys Gly Thr Pro Asp Glu Val Arg Glu Lys Ala Lys Ala Phe Val 
    690                 695                 700                 


Glu Lys Ile Arg Gly Cys Thr Glu 
705                 710         


<210>  101
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMPV F >AAK62968.2 fusion protein [Human metapneumovirus]


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  optionally absent

<400>  101

Met Ser Trp Lys Val Val Ile Ile Phe Ser Leu Leu Ile Thr Pro Gln 
1               5                   10                  15      


His Gly Leu Lys Glu Ser Tyr Leu Glu Glu Ser Cys Ser Thr Ile Thr 
            20                  25                  30          


Glu Gly Tyr Leu Ser Val Leu Arg Thr Gly Trp Tyr Thr Asn Val Phe 
        35                  40                  45              


Thr Leu Glu Val Gly Asp Val Glu Asn Leu Thr Cys Ala Asp Gly Pro 
    50                  55                  60                  


Ser Leu Ile Lys Thr Glu Leu Asp Leu Thr Lys Ser Ala Leu Arg Glu 
65                  70                  75                  80  


Leu Arg Thr Val Ser Ala Asp Gln Leu Ala Arg Glu Glu Gln Ile Glu 
                85                  90                  95      


Asn Pro Arg Gln Ser Arg Phe Val Leu Gly Ala Ile Ala Leu Gly Val 
            100                 105                 110         


Ala Thr Ala Ala Ala Val Thr Ala Gly Val Ala Ile Ala Lys Thr Ile 
        115                 120                 125             


Arg Leu Glu Ser Glu Val Thr Ala Ile Lys Asn Ala Leu Lys Lys Thr 
    130                 135                 140                 


Asn Glu Ala Val Ser Thr Leu Gly Asn Gly Val Arg Val Leu Ala Thr 
145                 150                 155                 160 


Ala Val Arg Glu Leu Lys Asp Phe Val Ser Lys Asn Leu Thr Arg Ala 
                165                 170                 175     


Ile Asn Lys Asn Lys Cys Asp Ile Ala Asp Leu Lys Met Ala Val Ser 
            180                 185                 190         


Phe Ser Gln Phe Asn Arg Arg Phe Leu Asn Val Val Arg Gln Phe Ser 
        195                 200                 205             


Asp Asn Ala Gly Ile Thr Pro Ala Ile Ser Leu Asp Leu Met Thr Asp 
    210                 215                 220                 


Ala Glu Leu Ala Arg Ala Val Ser Asn Met Pro Thr Ser Ala Gly Gln 
225                 230                 235                 240 


Ile Lys Leu Met Leu Glu Asn Arg Ala Met Val Arg Arg Lys Gly Phe 
                245                 250                 255     


Gly Phe Leu Ile Gly Val Tyr Gly Ser Ser Val Ile Tyr Met Val Gln 
            260                 265                 270         


Leu Pro Ile Phe Gly Val Ile Asp Thr Pro Cys Trp Ile Val Lys Ala 
        275                 280                 285             


Ala Pro Ser Cys Ser Gly Lys Lys Gly Asn Tyr Ala Cys Leu Leu Arg 
    290                 295                 300                 


Glu Asp Gln Gly Trp Tyr Cys Gln Asn Ala Gly Ser Thr Val Tyr Tyr 
305                 310                 315                 320 


Pro Asn Glu Lys Asp Cys Glu Thr Arg Gly Asp His Val Phe Cys Asp 
                325                 330                 335     


Thr Ala Ala Gly Ile Asn Val Ala Glu Gln Ser Lys Glu Cys Asn Ile 
            340                 345                 350         


Asn Ile Ser Thr Thr Asn Tyr Pro Cys Lys Val Ser Thr Gly Arg His 
        355                 360                 365             


Pro Ile Ser Met Val Ala Leu Ser Pro Leu Gly Ala Leu Val Ala Cys 
    370                 375                 380                 


Tyr Lys Gly Val Ser Cys Ser Ile Gly Ser Asn Arg Val Gly Ile Ile 
385                 390                 395                 400 


Lys Gln Leu Asn Lys Gly Cys Ser Tyr Ile Thr Asn Gln Asp Ala Asp 
                405                 410                 415     


Thr Val Thr Ile Asp Asn Thr Val Tyr Gln Leu Ser Lys Val Glu Gly 
            420                 425                 430         


Glu Gln His Val Ile Lys Gly Arg Pro Val Ser Ser Ser Phe Asp Pro 
        435                 440                 445             


Val Lys Phe Pro Glu Asp Gln Phe Asn Val Ala Leu Asp Gln Val Phe 
    450                 455                 460                 


Glu Ser Ile Glu Asn Ser Gln Ala Leu Val Asp Gln Ser Asn Arg Ile 
465                 470                 475                 480 


Leu Ser Ser Ala Glu Lys Gly Asn Thr Gly 
                485                 490 


