                               SEQUENCE LISTING

<110> CDI LABORATORIES, INC.
      THE JOHNS HOPKINS UNIVERSITY
 
<120> SEROLOGICAL BIOMARKERS FOR EARLY DIAGNOSIS OF LUNG CANCER

<130> 38759-713.601

<140> PCT/US2018/025726
<141> 2018-04-02

<150> 62/480,906
<151> 2017-04-03

<160> 121   

<170> PatentIn version 3.5

<210> 1
<211> 254
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Glu Ala Val Leu Arg Val Ala Arg Arg Gln Leu Ser Gln Arg 
1               5                   10                  15      


Gly Gly Ser Gly Ala Pro Ile Leu Leu Arg Gln Met Phe Glu Pro Val 
            20                  25                  30          


Ser Cys Thr Phe Thr Tyr Leu Leu Gly Asp Arg Glu Ser Arg Glu Ala 
        35                  40                  45              


Val Leu Ile Asp Pro Val Leu Glu Thr Ala Pro Arg Asp Ala Gln Leu 
    50                  55                  60                  


Ile Lys Glu Leu Gly Leu Arg Leu Leu Tyr Ala Val Asn Thr His Cys 
65                  70                  75                  80  


His Ala Asp His Ile Thr Gly Ser Gly Leu Leu Arg Ser Leu Leu Pro 
                85                  90                  95      


Gly Cys Gln Ser Val Ile Ser Arg Leu Ser Gly Ala Gln Ala Asp Leu 
            100                 105                 110         


His Ile Glu Asp Gly Asp Ser Ile Arg Phe Gly Arg Phe Ala Leu Glu 
        115                 120                 125             


Thr Arg Ala Ser Pro Gly His Thr Pro Gly Cys Val Thr Phe Val Leu 
    130                 135                 140                 


Asn Asp His Ser Met Ala Phe Thr Gly Asp Ala Leu Leu Ile Arg Gly 
145                 150                 155                 160 


Cys Gly Arg Thr Asp Phe Gln Gln Gly Cys Ala Lys Thr Leu Tyr His 
                165                 170                 175     


Ser Val His Glu Lys Ile Phe Thr Leu Pro Gly Asp Cys Leu Ile Tyr 
            180                 185                 190         


Pro Ala His Asp Tyr His Gly Phe Thr Val Ser Thr Val Glu Glu Glu 
        195                 200                 205             


Arg Thr Leu Asn Pro Arg Leu Thr Leu Ser Cys Glu Glu Phe Val Lys 
    210                 215                 220                 


Ile Met Gly Asn Leu Asn Leu Pro Lys Pro Gln Gln Ile Asp Phe Ala 
225                 230                 235                 240 


Val Pro Ala Asn Met Arg Cys Gly Val Gln Thr Pro Thr Ala 
                245                 250                 


<210> 2
<211> 682
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Thr Pro Ala Val Pro Gln Asp Leu Gln Leu Pro Pro Ser Gln 
1               5                   10                  15      


Arg Ala Gln Ser Ala Phe Lys Glu Gln Arg Arg Gln Lys Leu Lys Glu 
            20                  25                  30          


His Leu Leu Arg Arg Lys Thr Leu Phe Ala Tyr Lys Gln Glu Asn Glu 
        35                  40                  45              


Met Leu Ser Ser Arg Asp Gln Arg Val Val Thr Ser Glu Asp Gln Val 
    50                  55                  60                  


Gln Glu Gly Thr Lys Val Leu Lys Leu Lys Thr Lys Met Ala Asp Lys 
65                  70                  75                  80  


Glu Asn Met Lys Arg Pro Ala Glu Ser Lys Asn Asn Thr Val Val Gly 
                85                  90                  95      


Lys His Cys Ile Pro Leu Lys Pro Ser Asn Glu Leu Thr Asn Ser Thr 
            100                 105                 110         


Val Val Ile Asp Thr His Lys Pro Lys Asp Ser Asn Gln Thr Pro His 
        115                 120                 125             


Leu Leu Leu Thr Glu Asp Asp Pro Gln Ser Gln His Met Thr Leu Ser 
    130                 135                 140                 


Gln Ala Phe His Leu Lys Asn Asn Ser Lys Lys Lys Gln Met Thr Thr 
145                 150                 155                 160 


Glu Lys Gln Lys Gln Asp Ala Asn Met Pro Lys Lys Pro Val Leu Gly 
                165                 170                 175     


Ser Tyr Arg Gly Gln Ile Val Gln Ser Lys Ile Asn Ser Phe Arg Lys 
            180                 185                 190         


Pro Leu Gln Val Lys Asp Glu Ser Ser Ala Ala Thr Lys Lys Leu Ser 
        195                 200                 205             


Ala Thr Ile Pro Lys Ala Thr Lys Pro Gln Pro Val Asn Thr Ser Ser 
    210                 215                 220                 


Val Thr Val Lys Ser Asn Arg Ser Ser Asn Met Thr Ala Thr Thr Lys 
225                 230                 235                 240 


Phe Val Ser Thr Thr Ser Gln Asn Thr Gln Leu Val Arg Pro Pro Ile 
                245                 250                 255     


Arg Ser His His Ser Asn Thr Arg Asp Thr Val Lys Gln Gly Ile Ser 
            260                 265                 270         


Arg Thr Ser Ala Asn Val Thr Ile Arg Lys Gly Pro His Glu Lys Glu 
        275                 280                 285             


Leu Leu Gln Ser Lys Thr Ala Leu Ser Ser Val Lys Thr Ser Ser Ser 
    290                 295                 300                 


Gln Gly Ile Ile Arg Asn Lys Thr Leu Ser Arg Ser Ile Ala Ser Glu 
305                 310                 315                 320 


Val Val Ala Arg Pro Ala Ser Leu Ser Asn Asp Lys Leu Met Glu Lys 
                325                 330                 335     


Ser Glu Pro Val Asp Gln Arg Arg His Thr Ala Gly Lys Ala Ile Val 
            340                 345                 350         


Asp Ser Arg Ser Ala Gln Pro Lys Glu Thr Ser Glu Glu Arg Lys Ala 
        355                 360                 365             


Arg Leu Ser Glu Trp Lys Ala Gly Lys Gly Arg Val Leu Lys Arg Pro 
    370                 375                 380                 


Pro Asn Ser Val Val Thr Gln His Glu Pro Ala Gly Gln Asn Glu Lys 
385                 390                 395                 400 


Pro Val Gly Ser Phe Trp Thr Thr Met Ala Glu Glu Asp Glu Gln Arg 
                405                 410                 415     


Leu Phe Thr Glu Lys Val Asn Asn Thr Phe Ser Glu Cys Leu Asn Leu 
            420                 425                 430         


Ile Asn Glu Gly Cys Pro Lys Glu Asp Ile Leu Val Thr Leu Asn Asp 
        435                 440                 445             


Leu Ile Lys Asn Ile Pro Asp Ala Lys Lys Leu Val Lys Tyr Trp Ile 
    450                 455                 460                 


Cys Leu Ala Leu Ile Glu Pro Ile Thr Ser Pro Ile Glu Asn Ile Ile 
465                 470                 475                 480 


Ala Ile Tyr Glu Lys Ala Ile Leu Ala Gly Ala Gln Pro Ile Glu Glu 
                485                 490                 495     


Met Arg His Thr Ile Val Asp Ile Leu Thr Met Lys Ser Gln Glu Lys 
            500                 505                 510         


Ala Asn Leu Gly Glu Asn Met Glu Lys Ser Cys Ala Ser Lys Glu Glu 
        515                 520                 525             


Val Lys Glu Val Ser Ile Glu Asp Thr Gly Val Asp Val Asp Pro Glu 
    530                 535                 540                 


Lys Leu Glu Met Glu Ser Lys Leu His Arg Asn Leu Leu Phe Gln Asp 
545                 550                 555                 560 


Cys Glu Lys Glu Gln Asp Asn Lys Thr Lys Asp Pro Thr His Asp Val 
                565                 570                 575     


Lys Thr Pro Asn Thr Glu Thr Arg Thr Ser Cys Leu Ile Lys Tyr Asn 
            580                 585                 590         


Val Ser Thr Thr Pro Tyr Leu Gln Ser Val Lys Lys Lys Val Gln Phe 
        595                 600                 605             


Asp Gly Thr Asn Ser Ala Phe Lys Glu Leu Lys Phe Leu Thr Pro Val 
    610                 615                 620                 


Arg Arg Ser Arg Arg Leu Gln Glu Lys Thr Ser Lys Leu Pro Asp Met 
625                 630                 635                 640 


Leu Lys Asp His Tyr Pro Cys Val Ser Ser Leu Glu Gln Leu Thr Glu 
                645                 650                 655     


Leu Gly Arg Glu Thr Asp Ala Phe Val Cys Arg Pro Asn Ala Ala Leu 
            660                 665                 670         


Cys Arg Val Tyr Tyr Glu Ala Asp Thr Thr 
        675                 680         


<210> 3
<211> 766
<212> PRT
<213> Homo sapiens

<400> 3
Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210> 4
<211> 341
<212> PRT
<213> Homo sapiens

<400> 4
Met Pro Phe Pro Phe Gly Lys Ser His Lys Ser Pro Ala Asp Ile Val 
1               5                   10                  15      


Lys Asn Leu Lys Glu Ser Met Ala Val Leu Glu Lys Gln Asp Ile Ser 
            20                  25                  30          


Asp Lys Lys Ala Glu Lys Ala Thr Glu Glu Val Ser Lys Asn Leu Val 
        35                  40                  45              


Ala Met Lys Glu Ile Leu Tyr Gly Thr Asn Glu Lys Glu Pro Gln Thr 
    50                  55                  60                  


Glu Ala Val Ala Gln Leu Ala Gln Glu Leu Tyr Asn Ser Gly Leu Leu 
65                  70                  75                  80  


Ser Thr Leu Val Ala Asp Leu Gln Leu Ile Asp Phe Glu Gly Lys Lys 
                85                  90                  95      


Asp Val Ala Gln Ile Phe Asn Asn Ile Leu Arg Arg Gln Ile Gly Thr 
            100                 105                 110         


Arg Thr Pro Thr Val Glu Tyr Ile Cys Thr Gln Gln Asn Ile Leu Phe 
        115                 120                 125             


Met Leu Leu Lys Gly Tyr Glu Ser Pro Glu Ile Ala Leu Asn Cys Gly 
    130                 135                 140                 


Ile Met Leu Arg Glu Cys Ile Arg His Glu Pro Leu Ala Lys Ile Ile 
145                 150                 155                 160 


Leu Trp Ser Glu Gln Phe Tyr Asp Phe Phe Arg Tyr Val Glu Met Ser 
                165                 170                 175     


Thr Phe Asp Ile Ala Ser Asp Ala Phe Ala Thr Phe Lys Asp Leu Leu 
            180                 185                 190         


Thr Arg His Lys Leu Leu Ser Ala Glu Phe Leu Glu Gln His Tyr Asp 
        195                 200                 205             


Arg Phe Phe Ser Glu Tyr Glu Lys Leu Leu His Ser Glu Asn Tyr Val 
    210                 215                 220                 


Thr Lys Arg Gln Ser Leu Lys Leu Leu Gly Glu Leu Leu Leu Asp Arg 
225                 230                 235                 240 


His Asn Phe Thr Ile Met Thr Lys Tyr Ile Ser Lys Pro Glu Asn Leu 
                245                 250                 255     


Lys Leu Met Met Asn Leu Leu Arg Asp Lys Ser Arg Asn Ile Gln Phe 
            260                 265                 270         


Glu Ala Phe His Val Phe Lys Val Phe Val Ala Asn Pro Asn Lys Thr 
        275                 280                 285             


Gln Pro Ile Leu Asp Ile Leu Leu Lys Asn Gln Ala Lys Leu Ile Glu 
    290                 295                 300                 


Phe Leu Ser Lys Phe Gln Asn Asp Arg Thr Glu Asp Glu Gln Phe Asn 
305                 310                 315                 320 


Asp Glu Lys Thr Tyr Leu Val Lys Gln Ile Arg Asp Leu Lys Arg Pro 
                325                 330                 335     


Ala Gln Gln Glu Ala 
            340     


<210> 5
<211> 63
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Gly Ala Gly Ala Gly Ser Gly Phe Arg Lys Glu Leu Val Ser 
1               5                   10                  15      


Arg Leu Leu His Leu His Phe Lys Asp Asp Lys Thr Lys Glu Ala Ala 
            20                  25                  30          


Val Arg Gly Val Arg Gln Ala Gln Ala Glu Asp Ala Leu Arg Ala Asp 
        35                  40                  45              


Val Asp Gln Leu Glu Lys Val Leu Pro Gln Leu Leu Leu Asp Phe 
    50                  55                  60              


<210> 6
<211> 393
<212> PRT
<213> Homo sapiens

<400> 6
Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Arg Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210> 7
<211> 180
<212> PRT
<213> Homo sapiens

<400> 7
Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210> 8
<211> 281
<212> PRT
<213> Homo sapiens

<400> 8
Met Gly Ser Arg Gly Gln Gly Leu Leu Leu Ala Tyr Cys Leu Leu Leu 
1               5                   10                  15      


Ala Phe Ala Ser Gly Leu Val Leu Ser Arg Val Pro His Val Gln Gly 
            20                  25                  30          


Glu Gln Gln Glu Trp Glu Gly Thr Glu Glu Leu Pro Ser Pro Pro Asp 
        35                  40                  45              


His Ala Glu Arg Ala Glu Glu Gln His Glu Lys Tyr Arg Pro Ser Gln 
    50                  55                  60                  


Asp Gln Gly Leu Pro Ala Ser Arg Cys Leu Arg Cys Cys Asp Pro Gly 
65                  70                  75                  80  


Thr Ser Met Tyr Pro Ala Thr Ala Val Pro Gln Ile Asn Ile Thr Ile 
                85                  90                  95      


Leu Lys Gly Glu Lys Gly Asp Arg Gly Asp Arg Gly Leu Gln Gly Lys 
            100                 105                 110         


Tyr Gly Lys Thr Gly Ser Ala Gly Ala Arg Gly His Thr Gly Pro Lys 
        115                 120                 125             


Gly Gln Lys Gly Ser Met Gly Ala Pro Gly Glu Arg Cys Lys Ser His 
    130                 135                 140                 


Tyr Ala Ala Phe Ser Val Gly Arg Lys Lys Pro Met His Ser Asn His 
145                 150                 155                 160 


Tyr Tyr Gln Thr Val Ile Phe Asp Thr Glu Phe Val Asn Leu Tyr Asp 
                165                 170                 175     


His Phe Asn Met Phe Thr Gly Lys Phe Tyr Cys Tyr Val Pro Gly Leu 
            180                 185                 190         


Tyr Phe Phe Ser Leu Asn Val His Thr Trp Asn Gln Lys Glu Thr Tyr 
        195                 200                 205             


Leu His Ile Met Lys Asn Glu Glu Glu Val Val Ile Leu Phe Ala Gln 
    210                 215                 220                 


Val Gly Asp Arg Ser Ile Met Gln Ser Gln Ser Leu Met Leu Glu Leu 
225                 230                 235                 240 


Arg Glu Gln Asp Gln Val Trp Val Arg Leu Tyr Lys Gly Glu Arg Glu 
                245                 250                 255     


Asn Ala Ile Phe Ser Glu Glu Leu Asp Thr Tyr Ile Thr Phe Ser Gly 
            260                 265                 270         


Tyr Leu Val Lys His Ala Thr Glu Pro 
        275                 280     


<210> 9
<211> 313
<212> PRT
<213> Homo sapiens

<400> 9
Met Ser Asp Leu Leu Leu Leu Gly Leu Ile Gly Gly Leu Thr Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Leu Leu Ala Phe Ala Gly Tyr Ser Gly Leu Leu Ala 
            20                  25                  30          


Gly Val Glu Val Ser Ala Gly Ser Pro Pro Ile Arg Asn Val Thr Val 
        35                  40                  45              


Ala Tyr Lys Phe His Met Gly Leu Tyr Gly Glu Thr Gly Arg Leu Phe 
    50                  55                  60                  


Thr Glu Ser Cys Ser Ile Ser Pro Lys Leu Arg Ser Ile Ala Val Tyr 
65                  70                  75                  80  


Tyr Asp Asn Pro His Met Val Pro Pro Asp Lys Cys Arg Cys Ala Val 
                85                  90                  95      


Gly Ser Ile Leu Ser Glu Gly Glu Glu Ser Pro Ser Pro Glu Leu Ile 
            100                 105                 110         


Asp Leu Tyr Gln Lys Phe Gly Phe Lys Val Phe Ser Phe Pro Ala Pro 
        115                 120                 125             


Ser His Val Val Thr Ala Thr Phe Pro Tyr Thr Thr Ile Leu Ser Ile 
    130                 135                 140                 


Trp Leu Ala Thr Arg Arg Val His Pro Ala Leu Asp Thr Tyr Ile Lys 
145                 150                 155                 160 


Glu Arg Lys Leu Cys Ala Tyr Pro Arg Leu Glu Ile Tyr Gln Glu Asp 
                165                 170                 175     


Gln Ile His Phe Met Cys Pro Leu Ala Arg Gln Gly Asp Phe Tyr Val 
            180                 185                 190         


Pro Glu Met Lys Glu Thr Glu Trp Lys Trp Arg Gly Leu Val Glu Ala 
        195                 200                 205             


Ile Asp Thr Gln Val Asp Gly Thr Gly Ala Asp Thr Met Ser Asp Thr 
    210                 215                 220                 


Ser Ser Val Ser Leu Glu Val Ser Pro Gly Ser Arg Glu Thr Ser Ala 
225                 230                 235                 240 


Ala Thr Leu Ser Pro Gly Ala Ser Ser Arg Gly Trp Asp Asp Gly Asp 
                245                 250                 255     


Thr Arg Ser Glu His Ser Tyr Ser Glu Ser Gly Ala Ser Gly Ser Ser 
            260                 265                 270         


Phe Glu Glu Leu Asp Leu Glu Gly Glu Gly Pro Leu Gly Glu Ser Arg 
        275                 280                 285             


Leu Asp Pro Gly Thr Glu Pro Leu Gly Thr Thr Lys Trp Leu Trp Glu 
    290                 295                 300                 


Pro Thr Ala Pro Glu Lys Gly Lys Glu 
305                 310             


<210> 10
<211> 230
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Ser Leu Gly Leu Gln Leu Val Gly Tyr Ile Leu Gly Leu Leu 
1               5                   10                  15      


Gly Leu Leu Gly Thr Leu Val Ala Met Leu Leu Pro Ser Trp Lys Thr 
            20                  25                  30          


Ser Ser Tyr Val Gly Ala Ser Ile Val Thr Ala Val Gly Phe Ser Lys 
        35                  40                  45              


Gly Leu Trp Met Glu Cys Ala Thr His Ser Thr Gly Ile Thr Gln Cys 
    50                  55                  60                  


Asp Ile Tyr Ser Thr Leu Leu Gly Leu Pro Ala Asp Ile Gln Ala Ala 
65                  70                  75                  80  


Gln Ala Met Met Val Thr Ser Ser Ala Ile Ser Ser Leu Ala Cys Ile 
                85                  90                  95      


Ile Ser Val Val Gly Met Arg Cys Thr Val Phe Cys Gln Glu Ser Arg 
            100                 105                 110         


Ala Lys Asp Arg Val Ala Val Ala Gly Gly Val Phe Phe Ile Leu Gly 
        115                 120                 125             


Gly Leu Leu Gly Phe Ile Pro Val Ala Trp Asn Leu His Gly Ile Leu 
    130                 135                 140                 


Arg Asp Phe Tyr Ser Pro Leu Val Pro Asp Ser Met Lys Phe Glu Ile 
145                 150                 155                 160 


Gly Glu Ala Leu Tyr Leu Gly Ile Ile Ser Ser Leu Phe Ser Leu Ile 
                165                 170                 175     


Ala Gly Ile Ile Leu Cys Phe Ser Cys Ser Ser Gln Arg Asn Arg Ser 
            180                 185                 190         


Asn Tyr Tyr Asp Ala Tyr Gln Ala Gln Pro Leu Ala Thr Arg Ser Ser 
        195                 200                 205             


Pro Arg Pro Gly Gln Pro Pro Lys Val Lys Ser Glu Phe Asn Ser Tyr 
    210                 215                 220                 


Ser Leu Thr Gly Tyr Val 
225                 230 


<210> 11
<211> 185
<212> PRT
<213> Homo sapiens

<400> 11
Met Val Lys Leu Gly Asn Asn Phe Ala Glu Lys Gly Thr Lys Gln Pro 
1               5                   10                  15      


Leu Leu Glu Asp Gly Phe Asp Thr Ile Pro Leu Met Thr Pro Leu Asp 
            20                  25                  30          


Val Asn Gln Leu Gln Phe Pro Pro Pro Asp Lys Val Val Val Lys Thr 
        35                  40                  45              


Lys Thr Glu Tyr Glu Pro Asp Arg Lys Lys Gly Lys Ala Arg Pro Pro 
    50                  55                  60                  


Gln Ile Ala Glu Phe Thr Val Ser Ile Thr Glu Gly Val Thr Glu Arg 
65                  70                  75                  80  


Phe Lys Val Ser Val Leu Val Leu Phe Ala Leu Ala Phe Leu Thr Cys 
                85                  90                  95      


Val Val Phe Leu Val Val Tyr Lys Val Tyr Lys Tyr Asp Arg Ala Cys 
            100                 105                 110         


Pro Asp Gly Phe Val Leu Lys Asn Thr Gln Cys Ile Pro Glu Gly Leu 
        115                 120                 125             


Glu Ser Tyr Tyr Ala Glu Gln Asp Ser Ser Ala Arg Glu Lys Phe Tyr 
    130                 135                 140                 


Thr Val Ile Asn His Tyr Asn Leu Ala Lys Gln Ser Ile Thr Arg Ser 
145                 150                 155                 160 


Val Ser Pro Trp Met Ser Val Leu Ser Glu Glu Lys Leu Ser Glu Gln 
                165                 170                 175     


Glu Thr Glu Ala Ala Glu Lys Ser Ala 
            180                 185 


<210> 12
<211> 189
<212> PRT
<213> Homo sapiens

<400> 12
Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210> 13
<211> 325
<212> PRT
<213> Homo sapiens

<400> 13
Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Thr Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
                85                  90                  95      


Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys 
                165                 170                 175     


Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
            180                 185                 190         


Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met 
        195                 200                 205             


Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
    210                 215                 220                 


Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys 
225                 230                 235                 240 


Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn 
                245                 250                 255     


Arg Val Ile Glu Gly Gly Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
            260                 265                 270         


Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys 
        275                 280                 285             


Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr 
    290                 295                 300                 


Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu 
305                 310                 315                 320 


Thr Leu Gly Arg Lys 
                325 


<210> 14
<211> 499
<212> PRT
<213> Homo sapiens

<400> 14
Met Asp His Thr Glu Gly Ser Pro Ala Glu Glu Pro Pro Ala His Ala 
1               5                   10                  15      


Pro Ser Pro Gly Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg Leu Thr 
            20                  25                  30          


Arg Glu Ala Met Arg Asn Tyr Lys Glu Arg Gly Asp Gln Thr Val Leu 
        35                  40                  45              


Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn Glu Lys Arg 
    50                  55                  60                  


Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly Ser Gly Trp Lys 
65                  70                  75                  80  


Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser Glu Gln Glu Ser 
                85                  90                  95      


Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp Gln Glu Met Gln 
            100                 105                 110         


Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala Lys Thr Leu Tyr 
        115                 120                 125             


Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu Ser Val Lys Met 
    130                 135                 140                 


Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu Ser Lys Arg Ile 
145                 150                 155                 160 


Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser Leu Lys Asn Ala 
                165                 170                 175     


Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu Phe Asn Arg Leu 
            180                 185                 190         


Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val Glu Gly Gly Asn 
        195                 200                 205             


Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe Ile His Leu Leu 
    210                 215                 220                 


Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg Asp Gly Tyr 
225                 230                 235                 240 


Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser Val Thr Gly Met 
                245                 250                 255     


Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys Gln Thr Ala Leu 
            260                 265                 270         


Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys Ala Phe Tyr 
        275                 280                 285             


Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln Glu Arg Ile 
    290                 295                 300                 


Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn Lys Glu Met 
305                 310                 315                 320 


Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp Lys Ala Glu 
                325                 330                 335     


Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro Val Thr Pro 
            340                 345                 350         


Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly Asp Val Ala 
        355                 360                 365             


Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu Arg Val Trp 
    370                 375                 380                 


Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly Glu Ser Met 
385                 390                 395                 400 


Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly Trp Arg Trp 
                405                 410                 415     


Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg Asn Asp Gly 
            420                 425                 430         


Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro Glu Pro Gly 
        435                 440                 445             


Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu Arg Ala Asn Ser 
    450                 455                 460                 


Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu Gly Ser Tyr 
465                 470                 475                 480 


Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser Thr Ala Thr 
                485                 490                 495     


Val Val Ser 
            


<210> 15
<211> 487
<212> PRT
<213> Homo sapiens

<400> 15
Met Ala Pro Val Val Thr Gly Lys Phe Gly Glu Arg Pro Pro Pro Lys 
1               5                   10                  15      


Arg Leu Thr Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp 
            20                  25                  30          


Gln Thr Val Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly 
        35                  40                  45              


Asn Glu Lys Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly 
    50                  55                  60                  


Ser Gly Trp Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser 
65                  70                  75                  80  


Glu Gln Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp 
                85                  90                  95      


Gln Glu Met Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala 
            100                 105                 110         


Lys Thr Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu 
        115                 120                 125             


Ser Val Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu 
    130                 135                 140                 


Ser Lys Arg Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser 
145                 150                 155                 160 


Leu Lys Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu 
                165                 170                 175     


Phe Asn Arg Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val 
            180                 185                 190         


Glu Gly Gly Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe 
        195                 200                 205             


Ile His Leu Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val 
    210                 215                 220                 


Arg Asp Gly Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser 
225                 230                 235                 240 


Val Thr Gly Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys 
                245                 250                 255     


Gln Thr Ala Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys 
            260                 265                 270         


Cys Ala Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser 
        275                 280                 285             


Gln Glu Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro 
    290                 295                 300                 


Asn Lys Glu Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr 
305                 310                 315                 320 


Asp Lys Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala 
                325                 330                 335     


Pro Val Thr Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly 
            340                 345                 350         


Gly Asp Val Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn 
        355                 360                 365             


Leu Arg Val Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys 
    370                 375                 380                 


Gly Glu Ser Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu 
385                 390                 395                 400 


Gly Trp Arg Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val 
                405                 410                 415     


Arg Asn Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr 
            420                 425                 430         


Pro Glu Pro Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu 
        435                 440                 445             


Arg Ala Asn Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser 
    450                 455                 460                 


Glu Gly Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser 
465                 470                 475                 480 


Ser Thr Ala Thr Val Val Ser 
                485         


<210> 16
<211> 485
<212> PRT
<213> Homo sapiens

<400> 16
Met Gly Gly Cys Arg Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg Leu 
1               5                   10                  15      


Thr Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp Gln Thr 
            20                  25                  30          


Val Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn Glu 
        35                  40                  45              


Lys Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly Ser Gly 
    50                  55                  60                  


Trp Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser Glu Gln 
65                  70                  75                  80  


Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp Gln Glu 
                85                  90                  95      


Met Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala Lys Thr 
            100                 105                 110         


Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu Ser Val 
        115                 120                 125             


Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu Ser Lys 
    130                 135                 140                 


Arg Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser Leu Lys 
145                 150                 155                 160 


Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu Phe Asn 
                165                 170                 175     


Arg Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val Glu Gly 
            180                 185                 190         


Gly Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe Ile His 
        195                 200                 205             


Leu Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg Asp 
    210                 215                 220                 


Gly Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser Val Thr 
225                 230                 235                 240 


Gly Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys Gln Thr 
                245                 250                 255     


Ala Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys Ala 
            260                 265                 270         


Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln Glu 
        275                 280                 285             


Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn Lys 
    290                 295                 300                 


Glu Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp Lys 
305                 310                 315                 320 


Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro Val 
                325                 330                 335     


Thr Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly Asp 
            340                 345                 350         


Val Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu Arg 
        355                 360                 365             


Val Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly Glu 
    370                 375                 380                 


Ser Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly Trp 
385                 390                 395                 400 


Arg Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg Asn 
                405                 410                 415     


Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro Glu 
            420                 425                 430         


Pro Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu Arg Ala 
        435                 440                 445             


Asn Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu Gly 
    450                 455                 460                 


Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser Thr 
465                 470                 475                 480 


Ala Thr Val Val Ser 
                485 


<210> 17
<211> 300
<212> PRT
<213> Homo sapiens

<400> 17
Met Gln Ser Asp Asp Val Ile Trp Asp Thr Leu Gly Asn Lys Gln Phe 
1               5                   10                  15      


Cys Ser Phe Lys Ile Arg Thr Lys Thr Gln Ser Phe Cys Arg Asn Glu 
            20                  25                  30          


Tyr Ser Leu Thr Gly Leu Cys Asn Arg Ser Ser Cys Pro Leu Ala Asn 
        35                  40                  45              


Ser Gln Tyr Ala Thr Ile Lys Glu Glu Lys Gly Gln Cys Tyr Leu Tyr 
    50                  55                  60                  


Met Lys Val Ile Glu Arg Ala Ala Phe Pro Arg Arg Leu Trp Glu Arg 
65                  70                  75                  80  


Val Arg Leu Ser Lys Asn Tyr Glu Lys Ala Leu Glu Gln Ile Asp Glu 
                85                  90                  95      


Asn Leu Ile Tyr Trp Pro Arg Phe Ile Arg His Lys Cys Lys Gln Arg 
            100                 105                 110         


Phe Thr Lys Ile Thr Gln Tyr Leu Ile Arg Ile Arg Lys Leu Thr Leu 
        115                 120                 125             


Lys Arg Gln Arg Lys Leu Val Pro Leu Ser Lys Lys Val Glu Arg Arg 
    130                 135                 140                 


Glu Lys Arg Arg Glu Glu Lys Ala Leu Ile Ala Ala Gln Leu Asp Asn 
145                 150                 155                 160 


Ala Ile Glu Lys Glu Leu Leu Glu Arg Leu Lys Gln Asp Thr Tyr Gly 
                165                 170                 175     


Asp Ile Tyr Asn Phe Pro Ile His Ala Phe Asp Lys Ala Leu Glu Gln 
            180                 185                 190         


Gln Glu Ala Glu Ser Asp Ser Ser Asp Thr Glu Glu Lys Asp Asp Asp 
        195                 200                 205             


Asp Asp Asp Glu Glu Asp Val Gly Lys Arg Glu Phe Val Glu Asp Gly 
    210                 215                 220                 


Glu Val Asp Glu Ser Asp Ile Ser Asp Phe Glu Asp Met Asp Lys Leu 
225                 230                 235                 240 


Asp Ala Ser Ser Asp Glu Asp Gln Asp Gly Lys Ser Ser Ser Glu Glu 
                245                 250                 255     


Glu Glu Glu Lys Ala Leu Ser Ala Lys His Lys Gly Lys Met Pro Leu 
            260                 265                 270         


Arg Gly Pro Leu Gln Arg Lys Arg Ala Tyr Val Glu Ile Glu Tyr Glu 
        275                 280                 285             


Gln Glu Thr Glu Pro Val Ala Lys Ala Lys Thr Thr 
    290                 295                 300 


<210> 18
<211> 446
<212> PRT
<213> Homo sapiens

<400> 18
Met Glu Glu Thr Ile Lys Asp Pro Pro Thr Ser Ala Val Leu Leu Asp 
1               5                   10                  15      


His Cys His Phe Ser Gln Val Ile Phe Asn Ser Val Glu Lys Phe Tyr 
            20                  25                  30          


Ile Pro Gly Gly Asp Val Thr Cys His Tyr Thr Phe Thr Gln His Phe 
        35                  40                  45              


Ile Pro Arg Arg Lys Asp Trp Ile Gly Ile Phe Arg Val Gly Trp Lys 
    50                  55                  60                  


Thr Thr Arg Glu Tyr Tyr Thr Phe Met Trp Val Thr Leu Pro Ile Asp 
65                  70                  75                  80  


Leu Asn Asn Lys Ser Ala Lys Gln Gln Glu Val Gln Phe Lys Ala Tyr 
                85                  90                  95      


Tyr Leu Pro Lys Asp Asp Glu Tyr Tyr Gln Phe Cys Tyr Val Asp Glu 
            100                 105                 110         


Asp Gly Val Val Arg Gly Ala Ser Ile Pro Phe Gln Phe Arg Pro Glu 
        115                 120                 125             


Asn Glu Glu Asp Ile Leu Val Val Thr Thr Gln Gly Glu Val Glu Glu 
    130                 135                 140                 


Ile Glu Gln His Asn Lys Glu Leu Cys Lys Glu Asn Gln Glu Leu Lys 
145                 150                 155                 160 


Asp Ser Cys Ile Ser Leu Gln Lys Gln Asn Ser Asp Met Gln Ala Glu 
                165                 170                 175     


Leu Gln Lys Lys Gln Glu Glu Leu Glu Thr Leu Gln Ser Ile Asn Lys 
            180                 185                 190         


Lys Leu Glu Leu Lys Val Lys Glu Gln Lys Asp Tyr Trp Glu Thr Glu 
        195                 200                 205             


Leu Leu Gln Leu Lys Glu Gln Asn Gln Lys Met Ser Ser Glu Asn Glu 
    210                 215                 220                 


Lys Met Gly Ile Arg Val Asp Gln Leu Gln Ala Gln Leu Ser Thr Gln 
225                 230                 235                 240 


Glu Lys Glu Met Glu Lys Leu Val Gln Gly Asp Gln Asp Lys Thr Glu 
                245                 250                 255     


Gln Leu Glu Gln Leu Lys Lys Glu Asn Asp His Leu Phe Leu Ser Leu 
            260                 265                 270         


Thr Glu Gln Arg Lys Asp Gln Lys Lys Leu Glu Gln Thr Val Glu Gln 
        275                 280                 285             


Met Lys Gln Asn Glu Thr Thr Ala Met Lys Lys Gln Gln Glu Leu Met 
    290                 295                 300                 


Asp Glu Asn Phe Asp Leu Ser Lys Arg Leu Ser Glu Asn Glu Ile Ile 
305                 310                 315                 320 


Cys Asn Ala Leu Gln Arg Gln Lys Glu Arg Leu Glu Gly Glu Asn Asp 
                325                 330                 335     


Leu Leu Lys Arg Glu Asn Ser Arg Leu Leu Ser Tyr Met Gly Leu Asp 
            340                 345                 350         


Phe Asn Ser Leu Pro Tyr Gln Val Pro Thr Ser Asp Glu Gly Gly Ala 
        355                 360                 365             


Arg Gln Asn Pro Gly Leu Ala Tyr Gly Asn Pro Tyr Ser Gly Ile Gln 
    370                 375                 380                 


Glu Ser Ser Ser Ala Ser Pro Leu Ser Ile Lys Lys Cys Pro Ile Cys 
385                 390                 395                 400 


Lys Ala Asp Asp Ile Cys Asp His Thr Leu Glu Gln Gln Gln Met Gln 
                405                 410                 415     


Pro Leu Cys Phe Asn Cys Pro Ile Cys Asp Lys Ile Phe Pro Ala Thr 
            420                 425                 430         


Glu Lys Gln Ile Phe Glu Asp His Val Phe Cys His Ser Leu 
        435                 440                 445     


<210> 19
<211> 298
<212> PRT
<213> Homo sapiens

<400> 19
Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys Val Asp Lys Val Ile 
1               5                   10                  15      


Gln Ala Gln Thr Ala Phe Ser Ala Asn Pro Ala Asn Pro Ala Ile Leu 
            20                  25                  30          


Ser Glu Ala Ser Ala Pro Ile Pro His Asp Gly Asn Leu Tyr Pro Arg 
        35                  40                  45              


Leu Tyr Pro Glu Leu Ser Gln Tyr Met Gly Leu Ser Leu Asn Glu Glu 
    50                  55                  60                  


Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro Leu Gln Gly 
65                  70                  75                  80  


Gln Leu Val Ala Arg Pro Ser Ser Ile Asn Tyr Met Val Ala Pro Val 
                85                  90                  95      


Thr Gly Asn Asp Val Gly Ile Arg Arg Ala Glu Ile Lys Gln Gly Ile 
            100                 105                 110         


Arg Glu Val Ile Leu Cys Lys Asp Gln Asp Gly Lys Ile Gly Leu Arg 
        115                 120                 125             


Leu Lys Ser Ile Asp Asn Gly Ile Phe Val Gln Leu Val Gln Ala Asn 
    130                 135                 140                 


Ser Pro Ala Ser Leu Val Gly Leu Arg Phe Gly Asp Gln Val Leu Gln 
145                 150                 155                 160 


Ile Asn Gly Glu Asn Cys Ala Gly Trp Ser Ser Asp Lys Ala His Lys 
                165                 170                 175     


Val Leu Lys Gln Ala Phe Gly Glu Lys Ile Thr Met Thr Ile Arg Asp 
            180                 185                 190         


Arg Pro Phe Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His 
        195                 200                 205             


Val Gly Phe Ile Phe Lys Asn Gly Lys Ile Thr Ser Ile Val Lys Asp 
    210                 215                 220                 


Ser Ser Ala Ala Arg Asn Gly Leu Leu Thr Glu His Asn Ile Cys Glu 
225                 230                 235                 240 


Ile Asn Gly Gln Asn Val Ile Gly Leu Lys Asp Ser Gln Ile Ala Asp 
                245                 250                 255     


Ile Leu Ser Thr Ser Gly Thr Val Val Thr Ile Thr Ile Met Pro Ala 
            260                 265                 270         


Phe Ile Phe Glu His Ile Ile Lys Arg Met Ala Pro Ser Ile Met Lys 
        275                 280                 285             


Ser Leu Met Asp His Thr Ile Pro Glu Val 
    290                 295             


<210> 20
<211> 359
<212> PRT
<213> Homo sapiens

<400> 20
Met Met Leu Ser Leu Asn Asn Leu Gln Asn Ile Ile Tyr Asn Pro Val 
1               5                   10                  15      


Ile Pro Phe Val Gly Thr Ile Pro Asp Gln Leu Asp Pro Gly Thr Leu 
            20                  25                  30          


Ile Val Ile Arg Gly His Val Pro Ser Asp Ala Asp Arg Phe Gln Val 
        35                  40                  45              


Asp Leu Gln Asn Gly Ser Ser Met Lys Pro Arg Ala Asp Val Ala Phe 
    50                  55                  60                  


His Phe Asn Pro Arg Phe Lys Arg Ala Gly Cys Ile Val Cys Asn Thr 
65                  70                  75                  80  


Leu Ile Asn Glu Lys Trp Gly Arg Glu Glu Ile Thr Tyr Asp Thr Pro 
                85                  90                  95      


Phe Lys Arg Glu Lys Ser Phe Glu Ile Val Ile Met Val Leu Lys Asp 
            100                 105                 110         


Lys Phe Gln Val Ala Val Asn Gly Lys His Thr Leu Leu Tyr Gly His 
        115                 120                 125             


Arg Ile Gly Pro Glu Lys Ile Asp Thr Leu Gly Ile Tyr Gly Lys Val 
    130                 135                 140                 


Asn Ile His Ser Ile Gly Phe Ser Phe Ser Ser Asp Leu Gln Ser Thr 
145                 150                 155                 160 


Gln Ala Ser Ser Leu Glu Leu Thr Glu Ile Ser Arg Glu Asn Val Pro 
                165                 170                 175     


Lys Ser Gly Thr Pro Gln Leu Pro Ser Asn Arg Gly Gly Asp Ile Ser 
            180                 185                 190         


Lys Ile Ala Pro Arg Thr Val Tyr Thr Lys Ser Lys Asp Ser Thr Val 
        195                 200                 205             


Asn His Thr Leu Thr Cys Thr Lys Ile Pro Pro Met Asn Tyr Val Ser 
    210                 215                 220                 


Lys Arg Leu Pro Phe Ala Ala Arg Leu Asn Thr Pro Met Gly Pro Gly 
225                 230                 235                 240 


Arg Thr Val Val Val Lys Gly Glu Val Asn Ala Asn Ala Lys Ser Phe 
                245                 250                 255     


Asn Val Asp Leu Leu Ala Gly Lys Ser Lys Asp Ile Ala Leu His Leu 
            260                 265                 270         


Asn Pro Arg Leu Asn Ile Lys Ala Phe Val Arg Asn Ser Phe Leu Gln 
        275                 280                 285             


Glu Ser Trp Gly Glu Glu Glu Arg Asn Ile Thr Ser Phe Pro Phe Ser 
    290                 295                 300                 


Pro Gly Met Tyr Phe Glu Met Ile Ile Tyr Cys Asp Val Arg Glu Phe 
305                 310                 315                 320 


Lys Val Ala Val Asn Gly Val His Ser Leu Glu Tyr Lys His Arg Phe 
                325                 330                 335     


Lys Glu Leu Ser Ser Ile Asp Thr Leu Glu Ile Asn Gly Asp Ile His 
            340                 345                 350         


Leu Leu Glu Val Arg Ser Trp 
        355                 


<210> 21
<211> 226
<212> PRT
<213> Homo sapiens

<400> 21
Met Ala Asp Pro Gln Ala Gly Ser Ala Ala Gly Asp Trp Glu Ile Asp 
1               5                   10                  15      


Val Glu Ser Leu Glu Leu Glu Glu Asp Val Cys Gly Ala Pro Arg Ser 
            20                  25                  30          


Thr Pro Pro Gly Pro Ser Pro Pro Pro Ala Asp Gly Asp Cys Glu Asp 
        35                  40                  45              


Asp Glu Asp Asp Asp Gly Val Asp Glu Asp Ala Glu Glu Glu Gly Asp 
    50                  55                  60                  


Gly Glu Glu Ala Gly Ala Ser Pro Gly Met Pro Gly Gln Pro Glu Gln 
65                  70                  75                  80  


Arg Gly Gly Pro Gln Pro Arg Pro Pro Leu Ala Pro Gln Ala Ser Pro 
                85                  90                  95      


Ala Gly Thr Gly Pro Arg Glu Arg Cys Thr Pro Ala Gly Gly Gly Ala 
            100                 105                 110         


Glu Pro Arg Lys Leu Ser Arg Thr Pro Lys Cys Ala Arg Cys Arg Asn 
        115                 120                 125             


His Gly Val Val Ser Cys Leu Lys Gly His Lys Arg Phe Cys Arg Trp 
    130                 135                 140                 


Arg Asp Cys Gln Cys Ala Asn Cys Leu Leu Val Val Glu Arg Gln Arg 
145                 150                 155                 160 


Val Met Ala Ala Gln Val Ala Leu Arg Arg Gln Gln Ala Thr Glu Asp 
                165                 170                 175     


Lys Lys Gly Leu Ser Gly Lys Gln Asn Asn Phe Glu Arg Lys Ala Val 
            180                 185                 190         


Tyr Gln Arg Gln Val Arg Ala Pro Ser Leu Leu Ala Lys Ser Ile Leu 
        195                 200                 205             


Glu Val Leu Leu Gly Leu Phe Tyr Ser Tyr Tyr Val Tyr Ile Met Asn 
    210                 215                 220                 


His Leu 
225     


<210> 22
<211> 8
<212> PRT
<213> Homo sapiens

<400> 22
Ala Val Leu Arg Val Ala Arg Arg 
1               5               


<210> 23
<211> 7
<212> PRT
<213> Homo sapiens

<400> 23
Gly Ala Pro Ile Leu Leu Arg 
1               5           


<210> 24
<211> 13
<212> PRT
<213> Homo sapiens

<400> 24
Met Phe Glu Pro Val Ser Cys Thr Phe Thr Tyr Leu Leu 
1               5                   10              


<210> 25
<211> 11
<212> PRT
<213> Homo sapiens

<400> 25
Arg Glu Ala Val Leu Ile Asp Pro Val Leu Glu 
1               5                   10      


<210> 26
<211> 11
<212> PRT
<213> Homo sapiens

<400> 26
His Thr Pro Gly Cys Val Thr Phe Val Leu Asn 
1               5                   10      


<210> 27
<211> 8
<212> PRT
<213> Homo sapiens

<400> 27
Thr Gly Asp Ala Leu Leu Ile Arg 
1               5               


<210> 28
<211> 14
<212> PRT
<213> Homo sapiens

<400> 28
Asn Pro Arg Leu Thr Leu Ser Cys Glu Glu Phe Val Lys Ile 
1               5                   10                  


<210> 29
<211> 14
<212> PRT
<213> Homo sapiens

<400> 29
Asn Leu Pro Lys Pro Gln Gln Ile Asp Phe Ala Val Pro Ala 
1               5                   10                  


<210> 30
<211> 17
<212> PRT
<213> Homo sapiens

<400> 30
Pro Ala Val Pro Gln Asp Leu Gln Leu Pro Pro Ser Gln Arg Ala Gln 
1               5                   10                  15      


Ser 
    


<210> 31
<211> 8
<212> PRT
<213> Homo sapiens

<400> 31
Leu Lys Glu His Leu Leu Arg Arg 
1               5               


<210> 32
<211> 9
<212> PRT
<213> Homo sapiens

<400> 32
Arg Asp Gln Arg Val Val Thr Ser Glu 
1               5                   


<210> 33
<211> 8
<212> PRT
<213> Homo sapiens

<400> 33
Glu Gly Thr Lys Val Leu Lys Leu 
1               5               


<210> 34
<211> 12
<212> PRT
<213> Homo sapiens

<400> 34
Asn Asn Thr Val Val Gly Lys His Cys Ile Pro Leu 
1               5                   10          


<210> 35
<211> 8
<212> PRT
<213> Homo sapiens

<400> 35
Thr Asn Ser Thr Val Val Ile Asp 
1               5               


<210> 36
<211> 8
<212> PRT
<213> Homo sapiens

<400> 36
Gln Thr Pro His Leu Leu Leu Thr 
1               5               


<210> 37
<211> 9
<212> PRT
<213> Homo sapiens

<400> 37
Gln His Met Thr Leu Ser Gln Ala Phe 
1               5                   


<210> 38
<211> 7
<212> PRT
<213> Homo sapiens

<400> 38
Lys Lys Pro Val Leu Gly Ser 
1               5           


<210> 39
<211> 7
<212> PRT
<213> Homo sapiens

<400> 39
Arg Gly Gln Ile Val Gln Ser 
1               5           


<210> 40
<211> 8
<212> PRT
<213> Homo sapiens

<400> 40
Arg Lys Pro Leu Gln Val Lys Asp 
1               5               


<210> 41
<211> 9
<212> PRT
<213> Homo sapiens

<400> 41
Ala Thr Lys Lys Leu Ser Ala Thr Ile 
1               5                   


<210> 42
<211> 12
<212> PRT
<213> Homo sapiens

<400> 42
Lys Pro Gln Pro Val Asn Thr Ser Ser Val Thr Val 
1               5                   10          


<210> 43
<211> 7
<212> PRT
<213> Homo sapiens

<400> 43
Thr Thr Lys Phe Val Ser Thr 
1               5           


<210> 44
<211> 11
<212> PRT
<213> Homo sapiens

<400> 44
Asn Thr Gln Leu Val Arg Pro Pro Ile Arg Ser 
1               5                   10      


<210> 45
<211> 16
<212> PRT
<213> Homo sapiens

<400> 45
Glu Lys Glu Leu Leu Gln Ser Lys Thr Ala Leu Ser Ser Val Lys Thr 
1               5                   10                  15      


<210> 46
<211> 11
<212> PRT
<213> Homo sapiens

<400> 46
Ile Ala Ser Glu Val Val Ala Arg Pro Ala Ser 
1               5                   10      


<210> 47
<211> 8
<212> PRT
<213> Homo sapiens

<400> 47
Ala Gly Lys Ala Ile Val Asp Ser 
1               5               


<210> 48
<211> 8
<212> PRT
<213> Homo sapiens

<400> 48
Pro Pro Asn Ser Val Val Thr Gln 
1               5               


<210> 49
<211> 10
<212> PRT
<213> Homo sapiens

<400> 49
Pro Lys Glu Asp Ile Leu Val Thr Leu Asn 
1               5                   10  


<210> 50
<211> 19
<212> PRT
<213> Homo sapiens

<400> 50
Asp Ala Lys Lys Leu Val Lys Tyr Trp Ile Cys Leu Ala Leu Ile Glu 
1               5                   10                  15      


Pro Ile Thr 
            


<210> 51
<211> 16
<212> PRT
<213> Homo sapiens

<400> 51
Ile Glu Asn Ile Ile Ala Ile Tyr Glu Lys Ala Ile Leu Ala Gly Ala 
1               5                   10                  15      


<210> 52
<211> 7
<212> PRT
<213> Homo sapiens

<400> 52
Arg His Thr Ile Val Asp Ile 
1               5           


<210> 53
<211> 8
<212> PRT
<213> Homo sapiens

<400> 53
Glu Val Lys Glu Val Ser Ile Glu 
1               5               


<210> 54
<211> 7
<212> PRT
<213> Homo sapiens

<400> 54
Thr Gly Val Asp Val Asp Pro 
1               5           


<210> 55
<211> 9
<212> PRT
<213> Homo sapiens

<400> 55
Leu His Arg Asn Leu Leu Phe Gln Asp 
1               5                   


<210> 56
<211> 9
<212> PRT
<213> Homo sapiens

<400> 56
Phe Lys Glu Leu Lys Phe Leu Thr Pro 
1               5                   


<210> 57
<211> 13
<212> PRT
<213> Homo sapiens

<400> 57
Leu Lys Asp His Tyr Pro Cys Val Ser Ser Leu Glu Gln 
1               5                   10              


<210> 58
<211> 17
<212> PRT
<213> Homo sapiens

<400> 58
Thr Asp Ala Phe Val Cys Arg Pro Asn Ala Ala Leu Cys Arg Val Tyr 
1               5                   10                  15      


Tyr 
    


<210> 59
<211> 10
<212> PRT
<213> Homo sapiens

<400> 59
Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp 
1               5                   10  


<210> 60
<211> 7
<212> PRT
<213> Homo sapiens

<400> 60
Ser Asp His Glu Tyr Leu Tyr 
1               5           


<210> 61
<211> 7
<212> PRT
<213> Homo sapiens

<400> 61
Asn Asn Ile Leu Val Phe Asn 
1               5           


<210> 62
<211> 7
<212> PRT
<213> Homo sapiens

<400> 62
Gly Asn Ser Ser Val Phe Leu 
1               5           


<210> 63
<211> 15
<212> PRT
<213> Homo sapiens

<400> 63
Pro Asp Gly Gln Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln 
1               5                   10                  15  


<210> 64
<211> 13
<212> PRT
<213> Homo sapiens

<400> 64
Trp Val Thr Trp Ser Pro Val Gly His Lys Leu Ala Tyr 
1               5                   10              


<210> 65
<211> 16
<212> PRT
<213> Homo sapiens

<400> 65
Trp Asn Asn Asp Ile Tyr Val Lys Ile Glu Pro Asn Leu Pro Ser Tyr 
1               5                   10                  15      


<210> 66
<211> 12
<212> PRT
<213> Homo sapiens

<400> 66
Tyr Glu Glu Glu Val Phe Ser Ala Tyr Ser Ala Leu 
1               5                   10          


<210> 67
<211> 7
<212> PRT
<213> Homo sapiens

<400> 67
Gly Thr Phe Leu Ala Tyr Ala 
1               5           


<210> 68
<211> 7
<212> PRT
<213> Homo sapiens

<400> 68
Ser Leu Ser Ser Val Thr Asn 
1               5           


<210> 69
<211> 8
<212> PRT
<213> Homo sapiens

<400> 69
Glu Arg Ile Ser Leu Gln Trp Leu 
1               5               


<210> 70
<211> 11
<212> PRT
<213> Homo sapiens

<400> 70
Gln Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr 
1               5                   10      


<210> 71
<211> 8
<212> PRT
<213> Homo sapiens

<400> 71
Arg Trp Asn Cys Leu Val Ala Arg 
1               5               


<210> 72
<211> 8
<212> PRT
<213> Homo sapiens

<400> 72
Tyr Arg His Ile Cys Tyr Phe Gln 
1               5               


<210> 73
<211> 7
<212> PRT
<213> Homo sapiens

<400> 73
Asp Lys Lys Asp Cys Thr Phe 
1               5           


<210> 74
<211> 17
<212> PRT
<213> Homo sapiens

<400> 74
Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr Tyr Ile 
1               5                   10                  15      


Ser 
    


<210> 75
<211> 7
<212> PRT
<213> Homo sapiens

<400> 75
Gly Leu Arg Val Leu Glu Asp 
1               5           


<210> 76
<211> 8
<212> PRT
<213> Homo sapiens

<400> 76
Met Leu Gln Asn Val Gln Met Pro 
1               5               


<210> 77
<211> 8
<212> PRT
<213> Homo sapiens

<400> 77
Lys Lys Leu Asp Phe Ile Ile Leu 
1               5               


<210> 78
<211> 9
<212> PRT
<213> Homo sapiens

<400> 78
Trp Tyr Gln Met Ile Leu Pro Pro His 
1               5                   


<210> 79
<211> 7
<212> PRT
<213> Homo sapiens

<400> 79
Trp Ala Thr Tyr Leu Ala Ser 
1               5           


<210> 80
<211> 7
<212> PRT
<213> Homo sapiens

<400> 80
Glu Asn Ile Ile Val Ala Ser 
1               5           


<210> 81
<211> 7
<212> PRT
<213> Homo sapiens

<400> 81
Tyr Tyr Asp Ser Val Tyr Thr 
1               5           


<210> 82
<211> 9
<212> PRT
<213> Homo sapiens

<400> 82
Lys Gln Val Glu Tyr Leu Leu Ile His 
1               5                   


<210> 83
<211> 10
<212> PRT
<213> Homo sapiens

<400> 83
His Lys Ser Pro Ala Asp Ile Val Lys Asn 
1               5                   10  


<210> 84
<211> 8
<212> PRT
<213> Homo sapiens

<400> 84
Glu Ser Met Ala Val Leu Glu Lys 
1               5               


<210> 85
<211> 11
<212> PRT
<213> Homo sapiens

<400> 85
Val Ser Lys Asn Leu Val Ala Met Lys Glu Ile 
1               5                   10      


<210> 86
<211> 11
<212> PRT
<213> Homo sapiens

<400> 86
Gln Thr Glu Ala Val Ala Gln Leu Ala Gln Glu 
1               5                   10      


<210> 87
<211> 17
<212> PRT
<213> Homo sapiens

<400> 87
Tyr Asn Ser Gly Leu Leu Ser Thr Leu Val Ala Asp Leu Gln Leu Ile 
1               5                   10                  15      


Asp 
    


<210> 88
<211> 8
<212> PRT
<213> Homo sapiens

<400> 88
Lys Asp Val Ala Gln Ile Phe Asn 
1               5               


<210> 89
<211> 19
<212> PRT
<213> Homo sapiens

<400> 89
Pro Thr Val Glu Tyr Ile Cys Thr Gln Gln Asn Ile Leu Phe Met Leu 
1               5                   10                  15      


Leu Lys Gly 
            


<210> 90
<211> 10
<212> PRT
<213> Homo sapiens

<400> 90
Gln Phe Tyr Asp Phe Phe Arg Tyr Val Glu 
1               5                   10  


<210> 91
<211> 10
<212> PRT
<213> Homo sapiens

<400> 91
Glu Tyr Glu Lys Leu Leu His Ser Glu Asn 
1               5                   10  


<210> 92
<211> 12
<212> PRT
<213> Homo sapiens

<400> 92
Gln Ser Leu Lys Leu Leu Gly Glu Leu Leu Leu Asp 
1               5                   10          


<210> 93
<211> 13
<212> PRT
<213> Homo sapiens

<400> 93
Gln Phe Glu Ala Phe His Val Phe Lys Val Phe Val Ala 
1               5                   10              


<210> 94
<211> 20
<212> PRT
<213> Homo sapiens

<400> 94
Thr Gln Pro Ile Leu Asp Ile Leu Leu Lys Asn Gln Ala Lys Leu Ile 
1               5                   10                  15      


Glu Phe Leu Ser 
            20  


<210> 95
<211> 8
<212> PRT
<213> Homo sapiens

<400> 95
Lys Thr Tyr Leu Val Lys Gln Ile 
1               5               


<210> 96
<211> 13
<212> PRT
<213> Homo sapiens

<400> 96
Arg Lys Glu Leu Val Ser Arg Leu Leu His Leu His Phe 
1               5                   10              


<210> 97
<211> 10
<212> PRT
<213> Homo sapiens

<400> 97
Lys Glu Ala Ala Val Arg Gly Val Arg Gln 
1               5                   10  


<210> 98
<211> 15
<212> PRT
<213> Homo sapiens

<400> 98
Leu Arg Ala Asp Val Asp Gln Leu Glu Lys Val Leu Pro Gln Leu 
1               5                   10                  15  


<210> 99
<211> 11
<212> PRT
<213> Homo sapiens

<400> 99
Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10      


<210> 100
<211> 11
<212> PRT
<213> Homo sapiens

<400> 100
His Ser Tyr Thr Ala Ser Tyr Asp Ile Tyr Asp 
1               5                   10      


<210> 101
<211> 11
<212> PRT
<213> Homo sapiens

<400> 101
Pro Glu Asn Asn Val Leu Ser Pro Leu Pro Ser 
1               5                   10      


<210> 102
<211> 10
<212> PRT
<213> Homo sapiens

<400> 102
Tyr Gly Phe Arg Leu Gly Phe Leu His Ser 
1               5                   10  


<210> 103
<211> 11
<212> PRT
<213> Homo sapiens

<400> 103
Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
1               5                   10      


<210> 104
<211> 20
<212> PRT
<213> Homo sapiens

<400> 104
Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu 
1               5                   10                  15      


Trp Val Asp Ser 
            20  


<210> 105
<211> 8
<212> PRT
<213> Homo sapiens

<400> 105
Arg Ala Met Ala Ile Tyr Lys Gln 
1               5               


<210> 106
<211> 14
<212> PRT
<213> Homo sapiens

<400> 106
His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg 
1               5                   10                  


<210> 107
<211> 11
<212> PRT
<213> Homo sapiens

<400> 107
Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val 
1               5                   10      


<210> 108
<211> 8
<212> PRT
<213> Homo sapiens

<400> 108
Pro Ile Leu Thr Ile Ile Thr Leu 
1               5               


<210> 109
<211> 9
<212> PRT
<213> Homo sapiens

<400> 109
Phe Glu Val Arg Val Cys Ala Cys Pro 
1               5                   


<210> 110
<211> 7
<212> PRT
<213> Homo sapiens

<400> 110
Pro His His Glu Leu Pro Pro 
1               5           


<210> 111
<211> 7
<212> PRT
<213> Homo sapiens

<400> 111
Asp Gly Glu Tyr Phe Thr Leu 
1               5           


<210> 112
<211> 7
<212> PRT
<213> Homo sapiens

<400> 112
Ala His Ser Ser His Leu Lys 
1               5           


<210> 113
<211> 8
<212> PRT
<213> Homo sapiens

<400> 113
Tyr Lys Leu Val Val Val Gly Ala 
1               5               


<210> 114
<211> 19
<212> PRT
<213> Homo sapiens

<400> 114
Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe 
1               5                   10                  15      


Val Asp Glu 
            


<210> 115
<211> 16
<212> PRT
<213> Homo sapiens

<400> 115
Tyr Arg Lys Gln Val Val Ile Asp Gly Glu Thr Cys Leu Leu Asp Ile 
1               5                   10                  15      


<210> 116
<211> 8
<212> PRT
<213> Homo sapiens

<400> 116
Glu Gly Phe Leu Cys Val Phe Ala 
1               5               


<210> 117
<211> 7
<212> PRT
<213> Homo sapiens

<400> 117
Phe Glu Asp Ile His Gln Tyr 
1               5           


<210> 118
<211> 16
<212> PRT
<213> Homo sapiens

<400> 118
Asp Val Pro Met Val Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg 
1               5                   10                  15      


<210> 119
<211> 15
<212> PRT
<213> Homo sapiens

<400> 119
Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu 
1               5                   10                  15  


<210> 120
<211> 11
<212> PRT
<213> Homo sapiens

<400> 120
Val Glu Asp Ala Phe Tyr Thr Leu Val Arg Glu 
1               5                   10      


<210> 121
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MISC_FEATURE
<222> (1)..(10)
<223> This sequence may encompass 5-10 residues

<400> 121
His His His His His His His His His His 
1               5                   10  


