                         SEQUENCE LISTING

<110>  Merrimack Pharmaceuticals, Inc.
 
<120>  Bispecific 4-1BB Agonist Molecules

<130>  239669-429088

<150>  62/480,904
<151>  2017-04-03

<150>  62/508,790
<151>  2017-05-19

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  256
<212>  PRT
<213>  Murine

<400>  1

Met Gly Asn Asn Cys Tyr Asn Val Val Val Ile Val Leu Leu Leu Val 
1               5                   10                  15      


Gly Cys Glu Lys Val Gly Ala Val Gln Asn Ser Cys Asp Asn Cys Gln 
            20                  25                  30          


Pro Gly Thr Phe Cys Arg Lys Tyr Asn Pro Val Cys Lys Ser Cys Pro 
        35                  40                  45              


Pro Ser Thr Phe Ser Ser Ile Gly Gly Gln Pro Asn Cys Asn Ile Cys 
    50                  55                  60                  


Arg Val Cys Ala Gly Tyr Phe Arg Phe Lys Lys Phe Cys Ser Ser Thr 
65                  70                  75                  80  


His Asn Ala Glu Cys Glu Cys Ile Glu Gly Phe His Cys Leu Gly Pro 
                85                  90                  95      


Gln Cys Thr Arg Cys Glu Lys Asp Cys Arg Pro Gly Gln Glu Leu Thr 
            100                 105                 110         


Lys Gln Gly Cys Lys Thr Cys Ser Leu Gly Thr Phe Asn Asp Gln Asn 
        115                 120                 125             


Gly Thr Gly Val Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Arg 
    130                 135                 140                 


Ser Val Leu Lys Thr Gly Thr Thr Glu Lys Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Pro Val Val Ser Phe Ser Pro Ser Thr Thr Ile Ser Val Thr Pro Glu 
                165                 170                 175     


Gly Gly Pro Gly Gly His Ser Leu Gln Val Leu Thr Leu Phe Leu Ala 
            180                 185                 190         


Leu Thr Ser Ala Leu Leu Leu Ala Leu Ile Phe Ile Thr Leu Leu Phe 
        195                 200                 205             


Ser Val Leu Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
    210                 215                 220                 


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
225                 230                 235                 240 


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
                245                 250                 255     


<210>  2
<211>  309
<212>  PRT
<213>  Murine

<400>  2

Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      


Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          


Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              


Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  


Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  


Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      


Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 


Asp Asn Pro Trp Glu 
305                 


<210>  3
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  4
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  5
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210>  6
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 


<210>  7
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
1               5                   10                  15      


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            20                  25                  30          


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        35                  40                  45              


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    50                  55                  60                  


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
65                  70                  75                  80  


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                85                  90                  95      


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            100                 105                 110         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        115                 120                 125             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    130                 135                 140                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
145                 150                 155                 160 


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170 


<210>  8
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapien

<400>  8

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                245                 250                 255     


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
            260                 265                 270         


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
        275                 280                 285             


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
    290                 295                 300                 


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
305                 310                 315                 320 


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
                325                 330                 335     


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
            340                 345                 350         


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
        355                 360                 365             


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
    370                 375                 380                 


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
385                 390                 395                 400 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
                405                 410                 415     


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu 
        435                 440                 445             


Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
    450                 455                 460                 


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
465                 470                 475                 480 


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
                485                 490                 495     


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
            500                 505                 510         


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
        515                 520                 525             


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
    530                 535                 540                 


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
545                 550                 555                 560 


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
                565                 570                 575     


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
            580                 585                 590         


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
        595                 600                 605             


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
    610                 615                 620                 


Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
                645                 650                 655     


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
            660                 665                 670         


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
        675                 680                 685             


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
    690                 695                 700                 


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
705                 710                 715                 720 


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                725                 730                 735     


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
            740                 745                 750         


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
        755                 760                 765             


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
    770                 775                 780                 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
785                 790                 795                 800 


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                805                 810                 815     


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            820                 825                 


<210>  9
<211>  895
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse

<400>  9

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Ala Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Arg Thr Glu Pro Arg Pro Ala Leu Thr 
                245                 250                 255     


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
            260                 265                 270         


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
        275                 280                 285             


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
    290                 295                 300                 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
305                 310                 315                 320 


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
                325                 330                 335     


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
            340                 345                 350         


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
        355                 360                 365             


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
    370                 375                 380                 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
385                 390                 395                 400 


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
                405                 410                 415     


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
            420                 425                 430         


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
        435                 440                 445             


Asp Asn Pro Trp Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr 
465                 470                 475                 480 


Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro 
                485                 490                 495     


Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val 
            500                 505                 510         


Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr 
        515                 520                 525             


Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln 
    530                 535                 540                 


Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro 
545                 550                 555                 560 


Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr 
                565                 570                 575     


Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala 
            580                 585                 590         


Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu 
        595                 600                 605             


Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln 
    610                 615                 620                 


Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala 
625                 630                 635                 640 


Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr 
                645                 650                 655     


Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro 
            660                 665                 670         


Trp Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn 
    690                 695                 700                 


Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser His 
705                 710                 715                 720 


Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys 
                725                 730                 735     


Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp 
            740                 745                 750         


His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg 
        755                 760                 765             


Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr 
    770                 775                 780                 


Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly 
785                 790                 795                 800 


His Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln 
                805                 810                 815     


Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys 
            820                 825                 830         


Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu 
        835                 840                 845             


Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His 
    850                 855                 860                 


Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr 
865                 870                 875                 880 


Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu 
                885                 890                 895 


<210>  10
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp 
        195                 200                 205             


Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
    210                 215                 220                 


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
225                 230                 235                 240 


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
                245                 250                 255     


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
            260                 265                 270         


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
        275                 280                 285             


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
    290                 295                 300                 


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
305                 310                 315                 320 


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
                325                 330                 335     


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
            340                 345                 350         


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
        355                 360                 365             


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu 
385                 390                 395                 400 


Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
                405                 410                 415     


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
            420                 425                 430         


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
        435                 440                 445             


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
    450                 455                 460                 


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
465                 470                 475                 480 


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
                485                 490                 495     


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
            500                 505                 510         


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
        515                 520                 525             


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
    530                 535                 540                 


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
545                 550                 555                 560 


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                565                 570                 575     


Pro Ser Pro Arg Ser Glu 
            580         


<210>  11
<211>  648
<212>  PRT
<213>  Murine

<400>  11

Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu 
1               5                   10                  15      


Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile 
            20                  25                  30          


Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu 
        35                  40                  45              


Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His 
    50                  55                  60                  


Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr 
65                  70                  75                  80  


Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr 
                85                  90                  95      


Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly His 
            100                 105                 110         


Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln Val 
        115                 120                 125             


Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys Ser 
    130                 135                 140                 


Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu 
145                 150                 155                 160 


Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His Gly 
                165                 170                 175     


Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr 
            180                 185                 190         


Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu Gly Gly 
        195                 200                 205             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Glu 
    210                 215                 220                 


Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg 
225                 230                 235                 240 


Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile Gly Cys Pro 
                245                 250                 255     


Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu Ala Lys 
            260                 265                 270         


Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser Gln Asp 
        275                 280                 285             


Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp 
    290                 295                 300                 


Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu 
305                 310                 315                 320 


Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly His Lys Val Gln 
                325                 330                 335     


Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln Val Asp Asp Phe 
            340                 345                 350         


Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys Ser Met Glu Asn 
        355                 360                 365             


Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly 
    370                 375                 380                 


His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His Gly Ala Gln Asp 
385                 390                 395                 400 


Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly 
                405                 410                 415     


Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Glu Pro Arg Pro 
        435                 440                 445             


Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn 
    450                 455                 460                 


Ala Asp Gln Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr 
465                 470                 475                 480 


Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala 
                485                 490                 495     


Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly 
            500                 505                 510         


Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu 
        515                 520                 525             


Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys 
    530                 535                 540                 


Leu Ser Pro Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val 
545                 550                 555                 560 


Ser Leu Val Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu 
                565                 570                 575     


Ala Leu Thr Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val 
            580                 585                 590         


Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu 
        595                 600                 605             


Ser Val Gly Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg 
    610                 615                 620                 


Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu 
625                 630                 635                 640 


Val Lys Pro Asp Asn Pro Trp Glu 
                645             


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Gly Gly Gly Ser 
1               5   


<210>  13
<211>  1130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly Val Gln 
1               5                   10                  15      


Cys Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Glu 
            20                  25                  30          


Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp 
        35                  40                  45              


Tyr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala His Ile Tyr Thr Lys Ser Tyr Asn Tyr Ala Thr Tyr Tyr Ser 
65                  70                  75                  80  


Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Ser 
                85                  90                  95      


Met Val Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Asp Gly Ser Gly Tyr Pro Ser Leu Asp Phe Trp 
        115                 120                 125             


Gly Gln Gly Thr Gln Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro 
225                 230                 235                 240 


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
            260                 265                 270         


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Ala Val Ser 
        275                 280                 285             


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
    290                 295                 300                 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Ala Ser Thr 
305                 310                 315                 320 


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
                325                 330                 335     


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
        355                 360                 365             


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
    370                 375                 380                 


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
385                 390                 395                 400 


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
            420                 425                 430         


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
        435                 440                 445             


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
    450                 455                 460                 


Thr Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
465                 470                 475                 480 


Gly Ser Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro 
                485                 490                 495     


Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser 
            500                 505                 510         


His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala 
        515                 520                 525             


Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn 
    530                 535                 540                 


Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu 
545                 550                 555                 560 


Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu 
                565                 570                 575     


Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr 
            580                 585                 590         


Gly His Lys Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro 
        595                 600                 605             


Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro 
    610                 615                 620                 


Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu 
625                 630                 635                 640 


Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu 
                645                 650                 655     


His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn 
            660                 665                 670         


Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu 
        675                 680                 685             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
    690                 695                 700                 


Thr Glu Pro Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly 
705                 710                 715                 720 


Thr Arg Glu Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile Gly 
                725                 730                 735     


Cys Pro Asn Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu 
            740                 745                 750         


Ala Lys Asn Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser 
        755                 760                 765             


Gln Asp Gly Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu 
    770                 775                 780                 


Glu Asp Lys Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr Val 
785                 790                 795                 800 


Phe Leu Glu Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly His Lys 
                805                 810                 815     


Val Gln Gly Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln Val Asp 
            820                 825                 830         


Asp Phe Asp Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys Ser Met 
        835                 840                 845             


Glu Asn Lys Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys 
    850                 855                 860                 


Ala Gly His Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His Gly Ala 
865                 870                 875                 880 


Gln Asp Ala Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser 
                885                 890                 895     


Phe Gly Leu Phe Leu Val Lys Pro Asp Asn Pro Trp Glu Gly Gly Gly 
            900                 905                 910         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Glu Pro 
        915                 920                 925             


Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu 
    930                 935                 940                 


Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile Gly Cys Pro Asn 
945                 950                 955                 960 


Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn 
                965                 970                 975     


Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly 
            980                 985                 990         


Ala Gly Ser Ser Tyr Leu Ser Gln  Gly Leu Arg Tyr Glu  Glu Asp Lys 
        995                 1000                 1005             


Lys Glu  Leu Val Val Asp Ser  Pro Gly Leu Tyr Tyr  Val Phe Leu 
    1010                 1015                 1020             


Glu Leu  Lys Leu Ser Pro Thr  Phe Thr Asn Thr Gly  His Lys Val 
    1025                 1030                 1035             


Gln Gly  Trp Val Ser Leu Val  Leu Gln Ala Lys Pro  Gln Val Asp 
    1040                 1045                 1050             


Asp Phe  Asp Asn Leu Ala Leu  Thr Val Glu Leu Phe  Pro Cys Ser 
    1055                 1060                 1065             


Met Glu  Asn Lys Leu Val Asp  Arg Ser Trp Ser Gln  Leu Leu Leu 
    1070                 1075                 1080             


Leu Lys  Ala Gly His Arg Leu  Ser Val Gly Leu Arg  Ala Tyr Leu 
    1085                 1090                 1095             


His Gly  Ala Gln Asp Ala Tyr  Arg Asp Trp Glu Leu  Ser Tyr Pro 
    1100                 1105                 1110             


Asn Thr  Thr Ser Phe Gly Leu  Phe Leu Val Lys Pro  Asp Asn Pro 
    1115                 1120                 1125             


Trp Glu  
    1130 


<210>  14
<211>  235
<212>  PRT
<213>  Murine

<400>  14

Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp Pro Met 
1               5                   10                  15      


Val Trp Ala Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Val Asn 
            20                  25                  30          


Val Gly Glu Thr Val Lys Ile Thr Cys Ser Gly Asp Gln Leu Pro Lys 
        35                  40                  45              


Tyr Phe Ala Asp Trp Phe His Gln Arg Ser Asp Gln Thr Ile Leu Gln 
    50                  55                  60                  


Val Ile Tyr Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Ile 
65                  70                  75                  80  


Ser Gly Ser Ser Ser Gly Thr Thr Ala Thr Leu Thr Ile Arg Asp Val 
                85                  90                  95      


Arg Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Phe Ser Gly Tyr Val Asp 
            100                 105                 110         


Ser Asp Ser Lys Leu Tyr Val Phe Gly Ser Gly Thr Gln Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr 
                165                 170                 175     


Pro Val Thr Gln Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp 
        195                 200                 205             


Glu Arg His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr 
    210                 215                 220                 


Val Glu Lys Ser Leu Ser Arg Ala Asp Cys Ser 
225                 230                 235 


<210>  15
<211>  916
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse

<400>  15

Met Ala Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
            20                  25                  30          


Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
        35                  40                  45              


Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
    50                  55                  60                  


Ile Val Thr Cys Val Val Val Ala Val Ser Glu Asp Asp Pro Asp Val 
65                  70                  75                  80  


Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
                85                  90                  95      


Gln Thr His Arg Glu Asp Tyr Ala Ser Thr Leu Arg Val Val Ser Ala 
            100                 105                 110         


Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
        115                 120                 125             


Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
    130                 135                 140                 


Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
145                 150                 155                 160 


Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
                165                 170                 175     


Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
            180                 185                 190         


Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
        195                 200                 205             


Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
    210                 215                 220                 


Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
225                 230                 235                 240 


Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Glu Pro 
            260                 265                 270         


Arg Pro Ala Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu 
        275                 280                 285             


Asn Asn Ala Asp Gln Val Thr Pro Val Ser His Ile Gly Cys Pro Asn 
    290                 295                 300                 


Thr Thr Gln Gln Gly Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn 
305                 310                 315                 320 


Gln Ala Ser Leu Cys Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly 
                325                 330                 335     


Ala Gly Ser Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys 
            340                 345                 350         


Lys Glu Leu Val Val Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu 
        355                 360                 365             


Leu Lys Leu Ser Pro Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly 
    370                 375                 380                 


Trp Val Ser Leu Val Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp 
385                 390                 395                 400 


Asn Leu Ala Leu Thr Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys 
                405                 410                 415     


Leu Val Asp Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His 
            420                 425                 430         


Arg Leu Ser Val Gly Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala 
        435                 440                 445             


Tyr Arg Asp Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu 
    450                 455                 460                 


Phe Leu Val Lys Pro Asp Asn Pro Trp Glu Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Glu Pro Arg Pro Ala 
                485                 490                 495     


Leu Thr Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala 
            500                 505                 510         


Asp Gln Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln 
        515                 520                 525             


Gln Gly Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser 
    530                 535                 540                 


Leu Cys Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser 
545                 550                 555                 560 


Ser Tyr Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu 
                565                 570                 575     


Val Val Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu 
            580                 585                 590         


Ser Pro Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser 
        595                 600                 605             


Leu Val Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala 
    610                 615                 620                 


Leu Thr Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp 
625                 630                 635                 640 


Arg Ser Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser 
                645                 650                 655     


Val Gly Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp 
            660                 665                 670         


Trp Glu Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val 
        675                 680                 685             


Lys Pro Asp Asn Pro Trp Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    690                 695                 700                 


Ser Gly Gly Gly Gly Ser Arg Thr Glu Pro Arg Pro Ala Leu Thr Ile 
705                 710                 715                 720 


Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln Val 
                725                 730                 735     


Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly Ser 
            740                 745                 750         


Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys Asn 
        755                 760                 765             


Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr Leu 
    770                 775                 780                 


Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val Asp 
785                 790                 795                 800 


Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro Thr 
                805                 810                 815     


Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val Leu 
            820                 825                 830         


Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr Val 
        835                 840                 845             


Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser Trp 
    850                 855                 860                 


Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly Leu 
865                 870                 875                 880 


Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu Leu 
                885                 890                 895     


Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro Asp 
            900                 905                 910         


Asn Pro Trp Glu 
        915     


<210>  16
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Met Ser Pro Thr Val Ile Ile Leu Ala Cys Leu Gly Phe Phe 
1               5                   10                  15      


Leu Asp Gln Ser Val Trp Ala His Val Gly Gly Gln Asp Lys Pro Phe 
            20                  25                  30          


Cys Ser Ala Trp Pro Ser Ala Val Val Pro Gln Gly Gly His Val Thr 
        35                  40                  45              


Leu Arg Cys His Tyr Arg Arg Gly Phe Asn Ile Phe Thr Leu Tyr Lys 
    50                  55                  60                  


Lys Asp Gly Val Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Trp Asn 
65                  70                  75                  80  


Ser Phe Leu Ile Ser Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg 
                85                  90                  95      


Cys Arg Gly Phe His Pro His Ser Pro Thr Glu Trp Ser Ala Pro Ser 
            100                 105                 110         


Asn Pro Leu Val Ile Met Val Thr Gly Leu Tyr Glu Lys Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Pro Gly Pro Thr Val Arg Ala Gly Glu Asn Val Thr Leu 
    130                 135                 140                 


Ser Cys Ser Ser Gln Ser Ser Phe Asp Ile Tyr His Leu Ser Arg Glu 
145                 150                 155                 160 


Gly Glu Ala His Glu Leu Arg Leu Pro Ala Val Pro Ser Ile Asn Gly 
                165                 170                 175     


Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly Glu Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Phe His Gly Ser Pro Tyr Glu Trp Ser Asp 
        195                 200                 205             


Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Pro Ser Ser Ser 
    210                 215                 220                 


Trp Pro Ser Pro Thr Glu Pro Ser Phe Lys Thr Gly Ile Ala Arg His 
225                 230                 235                 240 


Leu His Ala Val Ile Arg Tyr Ser Val Ala Ile Ile Leu Phe Thr Ile 
                245                 250                 255     


Leu Pro Phe Phe Leu Leu His Arg Trp Cys Ser Lys Lys Lys Asn Ala 
            260                 265                 270         


Ala Val Met Asn Gln Glu Pro Ala Gly His Arg Thr Val Asn Arg Glu 
        275                 280                 285             


Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp 
    290                 295                 300                 


His Cys Ile Phe Thr Gln Arg Lys Ile Thr Gly Pro Ser Gln Arg Ser 
305                 310                 315                 320 


Lys Arg Pro Ser Thr Asp Thr Ser Val Cys Ile Glu Leu Pro Asn Ala 
                325                 330                 335     


Glu Pro Arg Ala Leu Ser Pro Ala His Glu His His Ser Gln Ala Leu 
            340                 345                 350         


Met Gly Ser Ser Arg Glu Thr Thr Ala Leu Ser Gln Thr Gln Leu Ala 
        355                 360                 365             


Ser Ser Asn Val Pro Ala Ala Gly Ile 
    370                 375         


<210>  17
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Trp Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Ser Ser Pro Asn Ala Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Gln Ala 
    130                 135                 140                 


Cys Ala Ser Lys Asn Ser Ser Ser Leu Leu Cys Ile Asp Asn Glu Glu 
145                 150                 155                 160 


Glu Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile Gly Val 
                165                 170                 175     


Phe Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala 
            180                 185                 190         


Phe Lys His Glu Ile Lys Asp Ser Asp His Ala Glu Arg Asn Cys Ala 
        195                 200                 205             


Met Leu His Val Arg Gly Leu Ile Ser Asp Gln Cys Gly Ser Ser Arg 
    210                 215                 220                 


Ile Ile Arg Arg Gly Phe Ile Met Leu Thr Arg Leu Val Leu Asn Ser 
225                 230                 235                 240 


<210>  18
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  19
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asn Lys Gln Arg Gly Thr Tyr Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Leu Lys Gly Asn Lys Ile Ser Ile Ser 
            20                  25                  30          


Gly Thr Lys Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Ala 
        35                  40                  45              


Ser Ser Asp His Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Cys 
                85                  90                  95      


Ile Gly Val Leu Glu Gln Asn Asn Phe Ser Leu Asn Arg Arg Met Gln 
            100                 105                 110         


Lys Ala Arg His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser 
        115                 120                 125             


Asn Ser Cys Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Arg 
    130                 135                 140                 


Val Cys Trp Pro Val Leu Arg Arg Thr Leu Ile Cys Phe Leu 
145                 150                 155             


<210>  20
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Phe Val Leu Ile Leu Val Leu Ser Phe Tyr Glu Leu Val Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Thr Gly Pro Gly Lys Phe Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Val Phe Ser Cys Ser Leu Phe Pro Glu Thr Ser Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Asn Gln Phe His Ala Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Glu Asp Trp Glu Ser Lys Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Arg Gly Arg Thr Glu Phe Val Lys Asp Ser Ile Ala Gly Gly Arg 
                85                  90                  95      


Val Ser Leu Arg Leu Lys Asn Ile Thr Pro Ser Asp Ile Gly Leu Tyr 
            100                 105                 110         


Gly Cys Trp Phe Ser Ser Gln Ile Tyr Asp Glu Glu Ala Thr Trp Glu 
        115                 120                 125             


Leu Arg Val Ala Ala Leu Gly Ser Leu Pro Leu Ile Ser Ile Val Gly 
    130                 135                 140                 


Tyr Val Asp Gly Gly Ile Gln Leu Leu Cys Leu Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Gln Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Ser Asp Ser Arg Ala Asn Ala Asp Gly Tyr Ser Leu Tyr Asp Val Glu 
            180                 185                 190         


Ile Ser Ile Ile Val Gln Glu Asn Ala Gly Ser Ile Leu Cys Ser Ile 
        195                 200                 205             


His Leu Ala Glu Gln Ser His Glu Val Glu Ser Lys Val Leu Ile Gly 
    210                 215                 220                 


Glu Thr Phe Phe Gln Pro Ser Pro Trp Arg Leu Ala Ser Ile Leu Leu 
225                 230                 235                 240 


Gly Leu Leu Cys Gly Ala Leu Cys Gly Val Val Met Gly Met Ile Ile 
                245                 250                 255     


Val Phe Phe Lys Ser Lys Gly Lys Ile Gln Ala Glu Leu Asp Trp Arg 
            260                 265                 270         


Arg Lys His Gly Gln Ala Glu Leu Arg Asp Ala Arg Lys His Ala Val 
        275                 280                 285             


Glu Val Thr Leu Asp Pro Glu Thr Ala His Pro Lys Leu Cys Val Ser 
    290                 295                 300                 


Asp Leu Lys Thr Val Thr His Arg Lys Ala Pro Gln Glu Val Pro His 
305                 310                 315                 320 


Ser Glu Lys Arg Phe Thr Arg Lys Ser Val Val Ala Ser Gln Gly Phe 
                325                 330                 335     


Gln Ala Gly Lys His Tyr Trp Glu Val Asp Val Gly Gln Asn Val Gly 
            340                 345                 350         


Trp Tyr Val Gly Val Cys Arg Asp Asp Val Asp Arg Gly Lys Asn Asn 
        355                 360                 365             


Val Thr Leu Ser Pro Asn Asn Gly Tyr Trp Val Leu Arg Leu Thr Thr 
    370                 375                 380                 


Glu His Leu Tyr Phe Thr Phe Asn Pro His Phe Ile Ser Leu Pro Pro 
385                 390                 395                 400 


Ser Thr Pro Pro Thr Arg Val Gly Val Phe Leu Asp Tyr Glu Gly Gly 
                405                 410                 415     


Thr Ile Ser Phe Phe Asn Thr Asn Asp Gln Ser Leu Ile Tyr Thr Leu 
            420                 425                 430         


Leu Thr Cys Gln Phe Glu Gly Leu Leu Arg Pro Tyr Ile Gln His Ala 
        435                 440                 445             


Met Tyr Asp Glu Glu Lys Gly Thr Pro Ile Phe Ile Cys Pro Val Ser 
    450                 455                 460                 


Trp Gly 
465     


<210>  21
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln Ser 
    50                  55                  60                  


Leu Thr Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val Phe 
65                  70                  75                  80  


Val Cys Thr Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val 
                85                  90                  95      


Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Thr Ile Asn 
            100                 105                 110         


Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys Ile Thr Val Asp Arg Phe 
        115                 120                 125             


Ile Val Val Val Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg 
    130                 135                 140                 


Met Thr Trp Gly Lys Val Thr Ser Leu Leu Ile Trp Val Ile Ser Leu 
145                 150                 155                 160 


Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu Asp 
                165                 170                 175     


Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Thr Val Val Leu 
            180                 185                 190         


Ala Thr Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Thr Met Ile 
        195                 200                 205             


Val Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly Phe 
    210                 215                 220                 


Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val Phe 
225                 230                 235                 240 


Leu Leu Thr Gln Met Pro Phe Asn Leu Met Lys Phe Ile Arg Ser Thr 
                245                 250                 255     


His Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Ile Met Val 
            260                 265                 270         


Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr 
        275                 280                 285             


Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys 
    290                 295                 300                 


Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser 
305                 310                 315                 320 


Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu Ala 
                325                 330                 335     


Thr Ser Met Phe Gln Leu 
            340         


<210>  22
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Leu Met Leu Ser Leu Val Leu Ser Leu Leu Lys Leu Gly Ser 
1               5                   10                  15      


Gly Gln Trp Gln Val Phe Gly Pro Asp Lys Pro Val Gln Ala Leu Val 
            20                  25                  30          


Gly Glu Asp Ala Ala Phe Ser Cys Phe Leu Ser Pro Lys Thr Asn Ala 
        35                  40                  45              


Glu Ala Met Glu Val Arg Phe Phe Arg Gly Gln Phe Ser Ser Val Val 
    50                  55                  60                  


His Leu Tyr Arg Asp Gly Lys Asp Gln Pro Phe Met Gln Met Pro Gln 
65                  70                  75                  80  


Tyr Gln Gly Arg Thr Lys Leu Val Lys Asp Ser Ile Ala Glu Gly Arg 
                85                  90                  95      


Ile Ser Leu Arg Leu Glu Asn Ile Thr Val Leu Asp Ala Gly Leu Tyr 
            100                 105                 110         


Gly Cys Arg Ile Ser Ser Gln Ser Tyr Tyr Gln Lys Ala Ile Trp Glu 
        115                 120                 125             


Leu Gln Val Ser Ala Leu Gly Ser Val Pro Leu Ile Ser Ile Thr Gly 
    130                 135                 140                 


Tyr Val Asp Arg Asp Ile Gln Leu Leu Cys Gln Ser Ser Gly Trp Phe 
145                 150                 155                 160 


Pro Arg Pro Thr Ala Lys Trp Lys Gly Pro Gln Gly Gln Asp Leu Ser 
                165                 170                 175     


Thr Asp Ser Arg Thr Asn Arg Asp Met His Gly Leu Phe Asp Val Glu 
            180                 185                 190         


Ile Ser Leu Thr Val Gln Glu Asn Ala Gly Ser Ile Ser Cys Ser Met 
        195                 200                 205             


Arg His Ala His Leu Ser Arg Glu Val Glu Ser Arg Val Gln Ile Gly 
    210                 215                 220                 


Asp Thr Phe Phe Glu Pro Ile Ser Trp His Leu Ala Thr Lys Val Leu 
225                 230                 235                 240 


Gly Ile Leu Cys Cys Gly Leu Phe Phe Gly Ile Val Gly Leu Lys Ile 
                245                 250                 255     


Phe Phe Ser Lys Phe Gln Trp Lys Ile Gln Ala Glu Leu Asp Trp Arg 
            260                 265                 270         


Arg Lys His Gly Gln Ala Glu Leu Arg Asp Ala Arg Lys His Ala Val 
        275                 280                 285             


Glu Val Thr Leu Asp Pro Glu Thr Ala His Pro Lys Leu Cys Val Ser 
    290                 295                 300                 


Asp Leu Lys Thr Val Thr His Arg Lys Ala Pro Gln Glu Val Pro His 
305                 310                 315                 320 


Ser Glu Lys Arg Phe Thr Arg Lys Ser Val Val Ala Ser Gln Ser Phe 
                325                 330                 335     


Gln Ala Gly Lys His Tyr Trp Glu Val Asp Gly Gly His Asn Lys Arg 
            340                 345                 350         


Trp Arg Val Gly Val Cys Arg Asp Asp Val Asp Arg Arg Lys Glu Tyr 
        355                 360                 365             


Val Thr Leu Ser Pro Asp His Gly Tyr Trp Val Leu Arg Leu Asn Gly 
    370                 375                 380                 


Glu His Leu Tyr Phe Thr Leu Asn Pro Arg Phe Ile Ser Val Phe Pro 
385                 390                 395                 400 


Arg Thr Pro Pro Thr Lys Ile Gly Val Phe Leu Asp Tyr Glu Cys Gly 
                405                 410                 415     


Thr Ile Ser Phe Phe Asn Ile Asn Asp Gln Ser Leu Ile Tyr Thr Leu 
            420                 425                 430         


Thr Cys Arg Phe Glu Gly Leu Leu Arg Pro Tyr Ile Glu Tyr Pro Ser 
        435                 440                 445             


Tyr Asn Glu Gln Asn Gly Thr Pro Ile Val Ile Cys Pro Val Thr Gln 
    450                 455                 460                 


Glu Ser Glu Lys Glu Ala Ser Trp Gln Arg Ala Ser Ala Ile Pro Glu 
465                 470                 475                 480 


Thr Ser Asn Ser Glu Ser Ser Ser Gln Ala Thr Thr Pro Phe Leu Pro 
                485                 490                 495     


Arg Gly Glu Met 
            500 


<210>  23
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  24
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  25
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Lys Gln Arg Gly Thr Phe Ser Glu Val Ser Leu Ala Gln Asp 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Ser Ser Ile Ser 
            20                  25                  30          


Gly Thr Glu Gln Glu Ile Phe Gln Val Glu Leu Asn Leu Gln Asn Pro 
        35                  40                  45              


Ser Leu Asn His Gln Gly Ile Asp Lys Ile Tyr Asp Cys Gln Gly Leu 
    50                  55                  60                  


Leu Pro Pro Pro Glu Lys Leu Thr Ala Glu Val Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Ile Val Leu Met Ala Thr Val Leu Lys Thr Ile Val Leu Ile Pro Phe 
                85                  90                  95      


Leu Glu Gln Asn Asn Ser Ser Pro Asn Thr Arg Thr Gln Lys Ala Arg 
            100                 105                 110         


His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn Ser Cys 
        115                 120                 125             


Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu Leu Ala 
    130                 135                 140                 


Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu Glu Glu 
145                 150                 155                 160 


Met Lys Phe Leu Ala Ser Ile Leu Pro Ser Ser Trp Ile Gly Val Phe 
                165                 170                 175     


Arg Asn Ser Ser His His Pro Trp Val Thr Ile Asn Gly Leu Ala Phe 
            180                 185                 190         


Lys His Lys Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys Ala Val 
        195                 200                 205             


Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser Met Ile 
    210                 215                 220                 


Tyr His Cys Lys His Lys Leu 
225                 230     


<210>  26
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  27
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  28
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Arg 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  29
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu 
        35                  40                  45              


Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys 
65                  70                  75                  80  


Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu 
                85                  90                  95      


Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg 
        115                 120                 125             


Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln 
    290                 295                 300                 


Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile 
305                 310                 315                 320 


Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala 
    370                 375                 380             


<210>  30
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe 
1               5                   10                  15      


Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu 
            20                  25                  30          


Met Val Leu Ser Gln Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu 
        35                  40                  45              


Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg 
    50                  55                  60                  


Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asn Val Leu Gly Ala Lys 
65                  70                  75                  80  


Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu 
                85                  90                  95      


Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His Ser 
            100                 105                 110         


Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr Arg 
        115                 120                 125             


Gly Ser Arg His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn 
    130                 135                 140                 


Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln Thr 
145                 150                 155                 160 


Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys Thr 
                165                 170                 175     


Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu Gln 
            180                 185                 190         


Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro Met 
        195                 200                 205             


Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr 
    210                 215                 220                 


Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg 
225                 230                 235                 240 


Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val 
                245                 250                 255     


Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile 
            260                 265                 270         


Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly 
        275                 280                 285             


Asn His Gly Thr His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln 
    290                 295                 300                 


Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe 
305                 310                 315                 320 


Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser 
                325                 330                 335     


Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His 
            340                 345                 350         


Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln 
        355                 360                 365             


Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Thr 
    370                 375                 380             


<210>  31
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Ala Ala Ala Ser Pro Ala Phe Leu Leu Cys Leu Pro Leu Leu 
1               5                   10                  15      


His Leu Leu Ser Gly Trp Ser Arg Ala Gly Trp Val Asp Thr His Cys 
            20                  25                  30          


Leu Cys Tyr Asp Phe Ile Ile Thr Pro Lys Ser Arg Pro Glu Pro Gln 
        35                  40                  45              


Trp Cys Glu Val Gln Gly Leu Val Asp Glu Arg Pro Phe Leu His Tyr 
    50                  55                  60                  


Asp Cys Val Asn His Lys Ala Lys Ala Phe Ala Ser Leu Gly Lys Lys 
65                  70                  75                  80  


Val Asn Val Thr Lys Thr Trp Glu Glu Gln Thr Glu Thr Leu Arg Asp 
                85                  90                  95      


Val Val Asp Phe Leu Lys Gly Gln Leu Leu Asp Ile Gln Val Glu Asn 
            100                 105                 110         


Leu Ile Pro Ile Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 
        115                 120                 125             


His Glu Ala His Gly His Gly Arg Gly Ser Trp Gln Phe Leu Phe Asn 
    130                 135                 140                 


Gly Gln Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg Lys Trp Thr Ala 
145                 150                 155                 160 


Leu His Pro Gly Ala Lys Lys Met Thr Glu Lys Trp Glu Lys Asn Arg 
                165                 170                 175     


Asp Val Thr Met Phe Phe Gln Lys Ile Ser Leu Gly Asp Cys Lys Met 
            180                 185                 190         


Trp Leu Glu Glu Phe Leu Met Tyr Trp Glu Gln Met Leu Asp Pro Thr 
        195                 200                 205             


Lys Pro Pro Ser Leu Ala Pro Gly Thr Thr Gln Pro Lys Ala Met Ala 
    210                 215                 220                 


Thr Thr Leu Ser Pro Trp Ser Leu Leu Ile Ile Phe Leu Cys Phe Ile 
225                 230                 235                 240 


Leu Ala Gly Arg 
                


<210>  32
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ala Ala Ala Ala Thr Lys Ile Leu Leu Cys Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Gly Trp Ser Arg Ala Gly Arg Ala Asp Pro His Ser 
            20                  25                  30          


Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg 
        35                  40                  45              


Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr 
    50                  55                  60                  


Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys 
65                  70                  75                  80  


Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu 
                85                  90                  95      


Val Val Asp Ile Leu Thr Glu Gln Leu Arg Asp Ile Gln Leu Glu Asn 
            100                 105                 110         


Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 
        115                 120                 125             


Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Phe Asp 
    130                 135                 140                 


Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr Thr 
145                 150                 155                 160 


Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys 
                165                 170                 175     


Val Val Ala Met Ser Phe His Tyr Phe Ser Met Gly Asp Cys Ile Gly 
            180                 185                 190         


Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser 
        195                 200                 205             


Ala Gly Ala Pro Leu Ala Met Ser Ser Gly Thr Thr Gln Leu Arg Ala 
    210                 215                 220                 


Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Ile Leu Pro Cys 
225                 230                 235                 240 


Phe Ile Leu Pro Gly Ile 
                245     


<210>  33
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Ala Ala Ala Ser Pro Ala Ile Leu Pro Arg Leu Ala Ile Leu 
1               5                   10                  15      


Pro Tyr Leu Leu Phe Asp Trp Ser Gly Thr Gly Arg Ala Asp Ala His 
            20                  25                  30          


Ser Leu Trp Tyr Asn Phe Thr Ile Ile His Leu Pro Arg His Gly Gln 
        35                  40                  45              


Gln Trp Cys Glu Val Gln Ser Gln Val Asp Gln Lys Asn Phe Leu Ser 
    50                  55                  60                  


Tyr Asp Cys Gly Ser Asp Lys Val Leu Ser Met Gly His Leu Glu Glu 
65                  70                  75                  80  


Gln Leu Tyr Ala Thr Asp Ala Trp Gly Lys Gln Leu Glu Met Leu Arg 
                85                  90                  95      


Glu Val Gly Gln Arg Leu Arg Leu Glu Leu Ala Asp Thr Glu Leu Glu 
            100                 105                 110         


Asp Phe Thr Pro Ser Gly Pro Leu Thr Leu Gln Val Arg Met Ser Cys 
        115                 120                 125             


Glu Cys Glu Ala Asp Gly Tyr Ile Arg Gly Ser Trp Gln Phe Ser Phe 
    130                 135                 140                 


Asp Gly Arg Lys Phe Leu Leu Phe Asp Ser Asn Asn Arg Lys Trp Thr 
145                 150                 155                 160 


Val Val His Ala Gly Ala Arg Arg Met Lys Glu Lys Trp Glu Lys Asp 
                165                 170                 175     


Ser Gly Leu Thr Thr Phe Phe Lys Met Val Ser Met Arg Asp Cys Lys 
            180                 185                 190         


Ser Trp Leu Arg Asp Phe Leu Met His Arg Lys Lys Arg Leu Glu Pro 
        195                 200                 205             


Thr Ala Pro Pro Thr Met Ala Pro Gly Leu Ala Gln Pro Lys Ala Ile 
    210                 215                 220                 


Ala Thr Thr Leu Ser Pro Trp Ser Phe Leu Ile Ile Leu Cys Phe Ile 
225                 230                 235                 240 


Leu Pro Gly Ile 
                


<210>  34
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Arg Ile Ser Leu Thr Ser Ser Pro Val Arg Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ile Ala Leu Glu Ile Met Val Gly Gly His Ser 
            20                  25                  30          


Leu Cys Phe Asn Phe Thr Ile Lys Ser Leu Ser Arg Pro Gly Gln Pro 
        35                  40                  45              


Trp Cys Glu Ala Gln Val Phe Leu Asn Lys Asn Leu Phe Leu Gln Tyr 
    50                  55                  60                  


Asn Ser Asp Asn Asn Met Val Lys Pro Leu Gly Leu Leu Gly Lys Lys 
65                  70                  75                  80  


Val Tyr Ala Thr Ser Thr Trp Gly Glu Leu Thr Gln Thr Leu Gly Glu 
                85                  90                  95      


Val Gly Arg Asp Leu Arg Met Leu Leu Cys Asp Ile Lys Pro Gln Ile 
            100                 105                 110         


Lys Thr Ser Asp Pro Ser Thr Leu Gln Val Glu Met Phe Cys Gln Arg 
        115                 120                 125             


Glu Ala Glu Arg Cys Thr Gly Ala Ser Trp Gln Phe Ala Thr Asn Gly 
    130                 135                 140                 


Glu Lys Ser Leu Leu Phe Asp Ala Met Asn Met Thr Trp Thr Val Ile 
145                 150                 155                 160 


Asn His Glu Ala Ser Lys Ile Lys Glu Thr Trp Lys Lys Asp Arg Gly 
                165                 170                 175     


Leu Glu Lys Tyr Phe Arg Lys Leu Ser Lys Gly Asp Cys Asp His Trp 
            180                 185                 190         


Leu Arg Glu Phe Leu Gly His Trp Glu Ala Met Pro Glu Pro Thr Val 
        195                 200                 205             


Ser Pro Val Asn Ala Ser Asp Ile His Trp Ser Ser Ser Ser Leu Pro 
    210                 215                 220                 


Asp Arg Trp Ile Ile Leu Gly Ala Phe Ile Leu Leu Val Leu Met Gly 
225                 230                 235                 240 


Ile Val Leu Ile Cys Val Trp Trp Gln Asn Gly Glu Trp Gln Ala Gly 
                245                 250                 255     


Leu Trp Pro Leu Arg Thr Ser 
            260             


<210>  35
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Ala Ala Ala Ser Pro Ala Phe Leu Leu Arg Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Ser Trp Cys Arg Thr Gly Leu Ala Asp Pro His Ser 
            20                  25                  30          


Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg 
        35                  40                  45              


Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr 
    50                  55                  60                  


Asp Cys Gly Ser Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys 
65                  70                  75                  80  


Leu Asn Val Thr Thr Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu 
                85                  90                  95      


Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu Asn 
            100                 105                 110         


Tyr Ile Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 
        115                 120                 125             


Gln Lys Ala Glu Gly His Gly Ser Gly Ser Trp Gln Leu Ser Phe Asp 
    130                 135                 140                 


Gly Gln Ile Phe Leu Leu Phe Asp Ser Glu Asn Arg Met Trp Thr Thr 
145                 150                 155                 160 


Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys 
                165                 170                 175     


Asp Met Thr Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Thr Gly 
            180                 185                 190         


Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser 
        195                 200                 205             


Ala Gly Ala Pro Pro Thr Met Ser Ser Gly Thr Ala Gln Pro Arg Ala 
    210                 215                 220                 


Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Met Cys Leu Leu 
225                 230                 235                 240 


Ile Cys Ser Arg His Ser Leu Thr Gln Ser His Gly His His Pro Gln 
                245                 250                 255     


Ser Leu Gln Pro Pro Pro His Pro Pro Leu Leu His Pro Thr Trp Leu 
            260                 265                 270         


Leu Arg Arg Val Leu Trp Ser Asp Ser Tyr Gln Ile Ala Lys Arg Pro 
        275                 280                 285             


Leu Ser Gly Gly His Val Thr Arg Val Thr Leu Pro Ile Ile Gly Asp 
    290                 295                 300                 


Asp Ser His Ser Leu Pro Cys Pro Leu Ala Leu Tyr Thr Ile Asn Asn 
305                 310                 315                 320 


Gly Ala Ala Arg Tyr Ser Glu Pro Leu Gln Val Ser Ile Ser 
                325                 330                 


<210>  36
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Ala Ala Ala Ile Pro Ala Leu Leu Leu Cys Leu Pro Leu Leu 
1               5                   10                  15      


Phe Leu Leu Phe Gly Trp Ser Arg Ala Arg Arg Asp Asp Pro His Ser 
            20                  25                  30          


Leu Cys Tyr Asp Ile Thr Val Ile Pro Lys Phe Arg Pro Gly Pro Arg 
        35                  40                  45              


Trp Cys Ala Val Gln Gly Gln Val Asp Glu Lys Thr Phe Leu His Tyr 
    50                  55                  60                  


Asp Cys Gly Asn Lys Thr Val Thr Pro Val Ser Pro Leu Gly Lys Lys 
65                  70                  75                  80  


Leu Asn Val Thr Met Ala Trp Lys Ala Gln Asn Pro Val Leu Arg Glu 
                85                  90                  95      


Val Val Asp Ile Leu Thr Glu Gln Leu Leu Asp Ile Gln Leu Glu Asn 
            100                 105                 110         


Tyr Thr Pro Lys Glu Pro Leu Thr Leu Gln Ala Arg Met Ser Cys Glu 
        115                 120                 125             


Gln Lys Ala Glu Gly His Ser Ser Gly Ser Trp Gln Phe Ser Ile Asp 
    130                 135                 140                 


Gly Gln Thr Phe Leu Leu Phe Asp Ser Glu Lys Arg Met Trp Thr Thr 
145                 150                 155                 160 


Val His Pro Gly Ala Arg Lys Met Lys Glu Lys Trp Glu Asn Asp Lys 
                165                 170                 175     


Asp Val Ala Met Ser Phe His Tyr Ile Ser Met Gly Asp Cys Ile Gly 
            180                 185                 190         


Trp Leu Glu Asp Phe Leu Met Gly Met Asp Ser Thr Leu Glu Pro Ser 
        195                 200                 205             


Ala Gly Ala Pro Leu Ala Met Ser Ser Gly Thr Thr Gln Leu Arg Ala 
    210                 215                 220                 


Thr Ala Thr Thr Leu Ile Leu Cys Cys Leu Leu Ile Ile Leu Pro Cys 
225                 230                 235                 240 


Phe Ile Leu Pro Gly Ile 
                245     


<210>  37
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ser Gly Ser Gln Ser Glu Val Ala Pro Ser Pro Gln Ser Pro Arg 
1               5                   10                  15      


Ser Pro Glu Met Gly Arg Asp Leu Arg Pro Gly Ser Arg Val Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Leu Leu Val Tyr Leu Thr Gln Pro Gly Asn Gly 
        35                  40                  45              


Asn Glu Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser 
    50                  55                  60                  


Ser Asp Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His 
65                  70                  75                  80  


Leu Arg Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu 
                85                  90                  95      


Ser Trp Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu 
            100                 105                 110         


Met Ser Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile 
        115                 120                 125             


Val Ala His Gln Lys His Leu Leu Pro Thr Ser Pro Pro Ile Ser Gln 
    130                 135                 140                 


Ala Ser Glu Gly Ala Ser Ser Asp Ile His Thr Pro Ala Gln Met Leu 
145                 150                 155                 160 


Leu Ser Thr Leu Gln Ser Thr Gln Arg Pro Thr Leu Pro Val Gly Ser 
                165                 170                 175     


Leu Ser Ser Asp Lys Glu Leu Thr Arg Pro Asn Glu Thr Thr Ile His 
            180                 185                 190         


Thr Ala Gly His Ser Leu Ala Ala Gly Pro Glu Ala Gly Glu Asn Gln 
        195                 200                 205             


Lys Gln Pro Glu Lys Asn Ala Gly Pro Thr Ala Arg Thr Ser Ala Thr 
    210                 215                 220                 


Val Pro Val Leu Cys Leu Leu Ala Ile Ile Phe Ile Leu Thr Ala Ala 
225                 230                 235                 240 


Leu Ser Tyr Val Leu Cys Lys Arg Arg Arg Gly Gln Ser Pro Gln Ser 
                245                 250                 255     


Ser Pro Asp Leu Pro Val His Tyr Ile Pro Val Ala Pro Asp Ser Asn 
            260                 265                 270         


Thr 
    


<210>  38
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  39
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  40
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Met Ala Ala Thr 
1               5                   10                  15      


Phe Ser Pro Gln Gly Leu Ala Gln Pro Asp Ser Val Ser Ile Pro Ile 
            20                  25                  30          


Thr Cys Cys Phe Asn Val Ile Asn Arg Lys Ile Pro Ile Gln Arg Leu 
        35                  40                  45              


Glu Ser Tyr Thr Arg Ile Thr Asn Ile Gln Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Lys Arg Gly Lys Glu Val Cys Ala Asp Pro Lys Glu 
65                  70                  75                  80  


Arg Trp Val Arg Asp Ser Met Lys His Leu Asp Gln Ile Phe Gln Asn 
                85                  90                  95      


Leu Lys Pro 
            


<210>  41
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Phe Ser Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala 
            20                  25                  30          


Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala 
        35                  40                  45              


Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Gly Val Ile Phe 
    50                  55                  60                  


Leu Thr Lys Arg Ser Arg Gln Val Cys Ala Asp Pro Ser Glu Glu Trp 
65                  70                  75                  80  


Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90          


<210>  42
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Lys Leu Cys Val Thr Val Leu Ser Leu Leu Met Leu Val Ala Ala 
1               5                   10                  15      


Phe Cys Ser Pro Ala Leu Ser Ala Pro Met Gly Ser Asp Pro Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ala Arg Lys Leu Pro Arg Asn Phe Val 
        35                  40                  45              


Val Asp Tyr Tyr Glu Thr Ser Ser Leu Cys Ser Gln Pro Ala Val Val 
    50                  55                  60                  


Phe Gln Thr Lys Arg Ser Lys Gln Val Cys Ala Asp Pro Ser Glu Ser 
65                  70                  75                  80  


Trp Val Gln Glu Tyr Val Tyr Asp Leu Glu Leu Asn 
                85                  90          


<210>  43
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  44
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  45
<211>  1610
<212>  DNA
<213>  Homo sapiens

<400>  45
tcgagccgag tcactgcgtc ctggcagcag aagctgcacc atgtccatgt cacccacggt       60

catcatcctg gcatgtcttg ggttcttctt ggaccagagt gtgtgggcac acgtgggtgg      120

tcaggacaag cccttctgct ctgcctggcc cagcgctgtg gtgcctcaag gaggacacgt      180

gactcttcgg tgtcactatc gtcgtgggtt taacatcttc acgctgtaca agaaagatgg      240

ggtccctgtc cctgagctct acaacagaat attctggaac agtttcctca ttagccctgt      300

gaccccagca cacgcaggga cctacagatg tcgaggtttt cacccgcact cccccactga      360

gtggtcggca cccagcaacc ccctggtgat catggtcaca ggtctatatg agaaaccttc      420

gcttacagcc cggccgggcc ccacggttcg cgcaggagag aacgtgacct tgtcctgcag      480

ctcccagagc tcctttgaca tctaccatct atccagggag ggggaagccc atgaacttag      540

gctccctgca gtgcccagca tcaatggaac attccaggcc gacttccctc tgggtcctgc      600

cacccacgga gagacctaca gatgcttcgg ctctttccat ggatctccct acgagtggtc      660

agacccgagt gacccactgc ctgtttctgt cacaggaaac ccttctagta gttggccttc      720

acccactgaa ccaagcttca aaactggtat cgccagacac ctgcatgctg tgattaggta      780

ctcagtggcc atcatcctct ttaccatcct tcccttcttt ctccttcatc gctggtgctc      840

caaaaaaaaa aatgctgctg taatgaacca agagcctgcg ggacacagaa cagtgaacag      900

ggaggactct gatgaacaag accctcagga ggtgacatac gcacagttgg atcactgcat      960

tttcacacag agaaaaatca ctggcccttc tcagaggagc aagagaccct caacagatac     1020

cagcgtgtgt atagaacttc caaatgctga gcccagagcg ttgtctcctg cccatgagca     1080

ccacagtcag gccttgatgg gatcttctag ggagacaaca gccctgtctc aaacccagct     1140

tgccagctct aatgtaccag cagctggaat ctgaaggcgt gagtctccat cttagagcat     1200

cactcttcct cacaccacaa atctggtgcc tgtctcttgc ttaccaatgt ctaaggtccc     1260

cactgcctgc tgcagagaaa acacactcct ttgcttagcc cacaattctc tatttcactt     1320

gacccctgcc cacctctcca acctaactgg cttacttcct agtctacttg aggctgcaat     1380

cacactgagg aactcacaat tccaaacata caagaggctc tctcttaaca cggcacttag     1440

acacgtgctg ttccaccttc cctcgtgctg ttccaccttt cctcagacta tttttcagcc     1500

ttctggcatc agcaaacctt ataaaatttt tttgatttca gtgtagttct ctcctcttca     1560

aataaacatg tctgccttca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                1610


<210>  46
<211>  843
<212>  DNA
<213>  Homo sapiens

<400>  46
gcagttatca tagagcacag tccctcacat cacacagctg cagagatgag taaacaaaga       60

ggaaccttct cagaagtgag tctggcccag gacccaaagt ggcagcaaag gaaacctaaa      120

ggcaataaaa gctccatttc aggaaccgaa caggaaatat tccaagtaga attaaacctt      180

caaaatgctt ctctgaatca tcaagggatt gataaaatat atgactgcca aggtttactg      240

ccacctccag aaaagctcac tgccgaggtc ctaggaatca tttgcattgt cctgatggcc      300

actgtgttaa aaacaatagt tcttattcct ttcctggagc agaacaattc ttccccgaat      360

gcaagaaccc agaaagcacg tcattgtggc cattgtcctg aggagtggat tacatattcc      420

aacagttgtt attacattgg taaggaaaga agaacttggg aagagagttt gcaggcctgt      480

gcttcaaaga actcttctag tctgctttgt atagataatg aagaagaaat gaaatttctg      540

gccagcattt taccttcctc atggattggt gtgtttcgta acagcagtca tcatccatgg      600

gtgacaataa atggtttggc tttcaaacat gagataaaag actcagatca tgctgaacgt      660

aactgtgcaa tgctacatgt acgtggactt atatcagacc agtgtggatc ttcaagaatc      720

attgtgagca taagctttag aattaaagcg cttgagcttg cagtgcatca gataaaattt      780

tatatttgtt caaacagaaa tgatattatg attgcataag ccttaaaatg aattgtgtta      840

ttt                                                                    843


<210>  47
<211>  1606
<212>  DNA
<213>  Homo sapiens

<400>  47
actaagtatc tccactttca attctagatc aggaactgag gacatatcta aattttctag       60

ttttatagaa ggcttttatc cacaagaatc aagatcttcc ctctctgagc aggaatcctt      120

tgtgcattga agactttaga ttcctctctg cggtagacgt gcacttataa gtatttgatg      180

gggtggattc gtggtcggag gtctcgacac agctgggaga tgagtgaatt tcataattat      240

aacttggatc tgaagaagag tgatttttca acacgatggc aaaagcaaag atgtccagta      300

gtcaaaagca aatgtagaga aaatgcatct ccattttttt tctgctgctt catcgctgta      360

gccatgggaa tccgtttcat tattatggta acaatatgga gtgctgtatt cctaaactca      420

ttattcaacc aagaagttca aattcccttg accgaaagtt actgtggccc atgtcctaaa      480

aactggatat gttacaaaaa taactgctac caattttttg atgagagtaa aaactggtat      540

gagagccagg cttcttgtat gtctcaaaat gccagccttc tgaaagtata cagcaaagag      600

gaccaggatt tacttaaact ggtgaagtca tatcattgga tgggactagt acacattcca      660

acaaatggat cttggcagtg ggaagatggc tccattctct cacccaacct actaacaata      720

attgaaatgc agaagggaga ctgtgcactc tatgcctcga gctttaaagg ctatatagaa      780

aactgttcaa ctccaaatac gtacatctgc atgcaaagga ctgtgtaaag atgatcaacc      840

atctcaataa aagccaggaa cagagaagag attacaccag cggtaacact gccaactgag      900

actaaaggaa acaaacaaaa acaggacaaa atgaccaaag actgtcagat ttcttagact      960

ccacaggacc aaaccataga acaatttcac tgcaaacatg catgattctc caagacaaaa     1020

gaagagagat cctaaaggca attcagatat ccccaaggct gcctctccca ccacaagccc     1080

agagtggatg ggctggggga ggggtgctgt tttaatttct aaaggtagga ccaacaccca     1140

ggggatcagt gaaggaagag aaggccagca gatcactgag agtgcaaccc caccctccac     1200

aggaaattgc ctcatgggca gggccacagc agagagacac agcatgggca gtgccttccc     1260

tgcctgtggg ggtcatgctg ccacttttaa tgggtcctcc acccaacggg gtcagggagg     1320

tggtgctgcc ccagtgggcc atgattatct taaaggcatt attctccagc cttaagtaag     1380

atcttaggac gtttcctttg ctatgatttg tacttgcttg agtcccatga ctgtttctct     1440

tcctctcttt cttccttttg gaatagtaat atccatccta tgtttgtccc actattgtat     1500

tttggaagca cataacttgt ttggtttcac aggttcacag ttaagaagga attttgcctc     1560

tgaataaata gaatcttgag tctcatgcaa aaaaaaaaaa aaaaaa                    1606


<210>  48
<211>  928
<212>  DNA
<213>  Homo sapiens

<400>  48
taaaacttta ggaaattagt accagacttt tatattggtc aacagcaaaa tgaacattac       60

tactcagcct ccaacacatg cagtttgcct ataccaggga tcctgtcaaa atatacacca      120

cttatagctt cttaagtgca gttatcatag agcacagtcc ctgacatcac acagctgcag      180

agatgaataa acaaagagga acctactcag aagtgagtct ggcccaggac ccaaagaggc      240

agcaaaggaa acttaagggc aataaaatct ccatttcagg aaccaaacag gaaatattcc      300

aagtagaatt aaaccttcaa aatgcttctt cggatcatca agggaatgac aagacatatc      360

actgcaaagg tttactgcca cctccagaga agctcactgc tgaggtccta ggaatcattt      420

gcattgtcct gatggccact gtgttaaaaa caatagttct tattccttgt attggagtac      480

tggagcagaa caatttttcc ctgaatagaa gaatgcagaa agcacgtcat tgtggccatt      540

gtcctgagga gtggattaca tattccaaca gttgttatta cattggtaag gaaagaagaa      600

cttgggaaga aagagtttgc tggcctgtgc ttcgaagaac tctgatctgc tttctataga      660

taatgaggaa gaaatggtaa gacgtaaatg tttcaacact ttactaaaag cttatttctg      720

tcaatatcat atttgtagaa atcatccata tgtttataca tatatttact tcatatattt      780

ttaagtctgt gtagtattca actgacttca taatattttt atattcatat actgttaatg      840

cacatttggt tatttccagt tttgcttttc atggaaaccc atgcttctat aaatgttttt      900

atcacaaaat aaatataaag aaaactaa                                         928


<210>  49
<211>  2454
<212>  DNA
<213>  Homo sapiens

<400>  49
catactcctc attcatacag ccatgtttag ggaggctcta gggagaaatg cacagtttga       60

catcgttcat gaagagcctc tccacggctc ctgcgcctga gacagctggc ctgacctcca      120

aatcatccat ccacccctgc tgtcatctgt tttcatagtg tgagatcaac ccacaggaat      180

atccatggct tttgtgctca ttttggttct cagtttctac gagctggtgt caggacagtg      240

gcaagtcact ggaccgggca agtttgtcca ggccttggtg ggggaggacg ccgtgttctc      300

ctgctccctc tttcctgaga ccagtgcaga ggctatggaa gtgcggttct tcaggaatca      360

gttccatgct gtggtccacc tctacagaga tggggaagac tgggaatcta agcagatgcc      420

acagtatcga gggagaactg agtttgtgaa ggactccatt gcaggggggc gtgtctctct      480

aaggctaaaa aacatcactc cctcggacat cggcctgtat gggtgctggt tcagttccca      540

gatttacgat gaggaggcca cctgggagct gcgggtggca gcactgggct cacttcctct      600

catttccatc gtgggatatg ttgacggagg tatccagtta ctctgcctgt cctcaggctg      660

gttcccccag cccacagcca agtggaaagg tccacaagga caggatttgt cttcagactc      720

cagagcaaat gcagatgggt acagcctgta tgatgtggag atctccatta tagtccagga      780

aaatgctggg agcatattgt gttccatcca ccttgctgag cagagtcatg aggtggaatc      840

caaggtattg ataggagaga cgtttttcca gccctcacct tggcgcctgg cttctatttt      900

actcgggtta ctctgtggtg ccctgtgtgg tgttgtcatg gggatgataa ttgttttctt      960

caaatccaaa gggaaaatcc aggcggaact ggactggaga agaaagcacg gacaggcaga     1020

attgagagac gcccggaaac acgcagtgga ggtgactctg gatccagaga cggctcaccc     1080

gaagctctgc gtttctgatc tgaaaactgt aacccataga aaagctcccc aggaggtgcc     1140

tcactctgag aagagattta caaggaagag tgtggtggct tctcagggtt tccaagcagg     1200

gaaacattac tgggaggtgg acgtgggaca aaatgtaggg tggtatgtgg gagtgtgtcg     1260

ggatgacgta gacaggggga agaacaatgt gactttgtct cccaacaatg ggtattgggt     1320

cctcagactg acaacagaac atttgtattt cacattcaat ccccatttta tcagcctccc     1380

ccccagcacc cctcctacac gagtaggggt cttcctggac tatgagggtg ggaccatctc     1440

cttcttcaat acaaatgacc agtcccttat ttataccctg ctgacatgtc agtttgaagg     1500

cttgttgaga ccctatatcc agcatgcgat gtatgacgag gaaaagggga ctcccatatt     1560

catatgtcca gtgtcctggg gatgagacag agaagaccct gcttaaaggg ccccacacca     1620

cagacccaga cacagccaag ggagagtgct cccgacaggt ggccccagct tcctctccgg     1680

agcctgcgca cagagagtca cgccccccac tctcctttag ggagctgagg ttcttctgcc     1740

ctgagccctg cagcagcggc agtcacagct tccagatgag gggggattgg cctgaccctg     1800

tgggagtcag aagccatggc tgccctgaag tggggacgga atagactcac attaggttta     1860

gtttgtgaaa actccatcca gctaagcgat cttgaacaag tcacaacctc ccaggctcct     1920

catttgctag tcacggacag tgattcctgc ctcacaggtg aagattaaag agacaacgaa     1980

tgtgaatcat gcttgcaggt ttgagggcac agtgtttgct aatgatgtgt ttttatatta     2040

tacattttcc caccataaac tctgtttgct tattccacat taatttactt ttctctatac     2100

caaatcaccc atggaatagt tattgaacac ctgctttgtg aggctcaaag aataaagagg     2160

aggtaggatt tttcactgat tctataagcc cagcattacc tgataccaaa accaggcaaa     2220

gaaaacagaa gaagaggaag gaaaactaca ggtccatatc cctcattaac acagacacaa     2280

aaattctaaa taaaatttta acaaattaaa ctaaacaata tatttaaaga tgatatataa     2340

ctactcagtg tggtttgtcc cacaaatgca gagttggttt aatatttaaa tatcaaccag     2400

tgtaattcag cacattaata aagtaaaaaa gaaaaccata aaaaaaaaaa aaaa           2454


<210>  50
<211>  1953
<212>  DNA
<213>  Homo sapiens

<400>  50
gcagaccttg cttcatgagc aagctcatct ctggaacaaa ctggcaaagc atctctgctg       60

gtgttcatca gaacagacac catggcagag catgattacc atgaagacta tgggttcagc      120

agtttcaatg acagcagcca ggaggagcat caagacttcc tgcagttcag caaggtcttt      180

ctgccctgca tgtacctggt ggtgtttgtc tgtggtctgg tggggaactc tctggtgctg      240

gtcatatcca tcttctacca taagttgcag agcctgacgg atgtgttcct ggtgaaccta      300

cccctggctg acctggtgtt tgtctgcact ctgcccttct gggcctatgc aggcatccat      360

gaatgggtgt ttggccaggt catgtgcaag agcctactgg gcatctacac tattaacttc      420

tacacgtcca tgctcatcct cacctgcatc actgtggatc gtttcattgt agtggttaag      480

gccaccaagg cctacaacca gcaagccaag aggatgacct ggggcaaggt caccagcttg      540

ctcatctggg tgatatccct gctggtttcc ttgccccaaa ttatctatgg caatgtcttt      600

aatctcgaca agctcatatg tggttaccat gacgaggcaa tttccactgt ggttcttgcc      660

acccagatga cactggggtt cttcttgcca ctgctcacca tgattgtctg ctattcagtc      720

ataatcaaaa cactgcttca tgctggaggc ttccagaagc acagatctct aaagatcatc      780

ttcctggtga tggctgtgtt cctgctgacc cagatgccct tcaacctcat gaagttcatc      840

cgcagcacac actgggaata ctatgccatg accagctttc actacaccat catggtgaca      900

gaggccatcg catacctgag ggcctgcctt aaccctgtgc tctatgcctt tgtcagcctg      960

aagtttcgaa agaacttctg gaaacttgtg aaggacattg gttgcctccc ttaccttggg     1020

gtctcacatc aatggaaatc ttctgaggac aattccaaga ctttttctgc ctcccacaat     1080

gtggaggcca ccagcatgtt ccagttatag gccttgccag ggtttcgaga agctgctctg     1140

gaatttgcaa gtcatggctg tgccctcttg atgtggtgag gcaggctttg tttatagctt     1200

gcgcattctc atggagaagt tatcagacac tctggctggt ttggaatgct tcttctcagg     1260

catgaacatg tactgttctc ttcttgaaca ctcatgctga aagcccaagt agggggtcta     1320

aaatttttaa ggactttcct tcctccatct ccaagaatgc tgaaaccaag ggggatgaca     1380

tgtgactcct atgatctcag gttctccttg attgggactg gggctgaagg ttgaagaggt     1440

gagcacggcc aacaaagctg ttgatggtag gtggcacact gggtgcccaa gctcagaagg     1500

ctcttctgac tactgggcaa agagtgtaga tcagagcagc agtgaaaaca agtgctggca     1560

ccaccaggca cctcacagaa atgagatcag gctctgcctc accttggggc ttgacttttg     1620

tataggtaga tgttcagatt gctttgatta atccagaata actagcacca gggactatga     1680

atgggcaaaa ctgaattata agaggctgat aattccagtg gtccatggaa tgcttgaaaa     1740

atgtgcaaaa cagcgtttaa gactgtaatg aatctaagca gcatttctga agtggactct     1800

ttggtggctt tgcattttaa aaatgaaatt ttccaatgtc tgccacacaa acgtatgtaa     1860

atgtatatac ccacacacat acacacatat gtcatatatt actagcatat gagtttcata     1920

gctaagaaat aaaactgtta aagtctccaa act                                  1953


<210>  51
<211>  2109
<212>  DNA
<213>  Homo sapiens

<400>  51
tagacattta tgcagtggtt caaagtctag agtccctaca cttctggtac atgacagctg       60

tgtctcgatg gagtagactc tcagaacagc gcagtttgcc ctccgctcac gcagagcctc      120

tccgtggctt ccgcaccttg agcattaggc cagttctcct cttctctcta atccatccgt      180

cacctctcct gtcatccgtt tccatgccgt gaggtccatt cacagaacac atccatggct      240

ctcatgctca gtttggttct gagtctcctc aagctgggat cagggcagtg gcaggtgttt      300

gggccagaca agcctgtcca ggccttggtg ggggaggacg cagcattctc ctgtttcctg      360

tctcctaaga ccaatgcaga ggccatggaa gtgcggttct tcaggggcca gttctctagc      420

gtggtccacc tctacaggga cgggaaggac cagccattta tgcagatgcc acagtatcaa      480

ggcaggacaa aactggtgaa ggattctatt gcggaggggc gcatctctct gaggctggaa      540

aacattactg tgttggatgc tggcctctat gggtgcagga ttagttccca gtcttactac      600

cagaaggcca tctgggagct acaggtgtca gcactgggct cagttcctct catttccatc      660

acgggatatg ttgatagaga catccagcta ctctgtcagt cctcgggctg gttcccccgg      720

cccacagcga agtggaaagg tccacaagga caggatttgt ccacagactc caggacaaac      780

agagacatgc atggcctgtt tgatgtggag atctctctga ccgtccaaga gaacgccggg      840

agcatatcct gttccatgcg gcatgctcat ctgagccgag aggtggaatc cagggtacag      900

ataggagata cctttttcga gcctatatcg tggcacctgg ctaccaaagt actgggaata      960

ctctgctgtg gcctattttt tggcattgtt ggactgaaga ttttcttctc caaattccag     1020

tggaaaatcc aggcggaact ggactggaga agaaagcacg gacaggcaga attgagagac     1080

gcccggaaac acgcagtgga ggtgactctg gatccagaga cggctcaccc gaagctctgc     1140

gtttctgatc tgaaaactgt aacccataga aaagctcccc aggaggtgcc tcactctgag     1200

aagagattta caaggaagag tgtggtggct tctcagagtt tccaagcagg gaaacattac     1260

tgggaggtgg acggaggaca caataaaagg tggcgcgtgg gagtgtgccg ggatgatgtg     1320

gacaggagga aggagtacgt gactttgtct cccgatcatg ggtactgggt cctcagactg     1380

aatggagaac atttgtattt cacattaaat ccccgtttta tcagcgtctt ccccaggacc     1440

ccacctacaa aaataggggt cttcctggac tatgagtgtg ggaccatctc cttcttcaac     1500

ataaatgacc agtcccttat ttataccctg acatgtcggt ttgaaggctt attgaggccc     1560

tacattgagt atccgtccta taatgagcaa aatggaactc ccatagtcat ctgcccagtc     1620

acccaggaat cagagaaaga ggcctcttgg caaagggcct ctgcaatccc agagacaagc     1680

aacagtgagt cctcctcaca ggcaaccacg cccttcctcc ccaggggtga aatgtaggat     1740

gaatcacatc ccacattctt ctttagggat attaaggtct ctctcccaga tccaaagtcc     1800

cgcagcagcc ggccaaggtg gcttccagat gaagggggac tggcctgtcc acatgggagt     1860

caggtgtcat ggctgccctg agctgggagg gaagaaggct gacattacat ttagtttgct     1920

ctcactccat ctggctaagt gatcttgaaa taccacctct caggtgaaga accgtcagga     1980

attcccatct cacaggctgt ggtgtagatt aagtagacaa ggaatgtgaa taatgcttag     2040

atcttattga tgacagagtg tatcctaatg gtttgttcat tatattacac tttcagtaaa     2100

aaaaaaaaa                                                             2109


<210>  52
<211>  2115
<212>  DNA
<213>  Homo sapiens

<400>  52
agtttccctt ccgctcacct ccgcctgagc agtggagaag gcggcactct ggtggggctg       60

ctccaggcat gcagatccca caggcgccct ggccagtcgt ctgggcggtg ctacaactgg      120

gctggcggcc aggatggttc ttagactccc cagacaggcc ctggaacccc cccaccttct      180

ccccagccct gctcgtggtg accgaagggg acaacgccac cttcacctgc agcttctcca      240

acacatcgga gagcttcgtg ctaaactggt accgcatgag ccccagcaac cagacggaca      300

agctggccgc cttccccgag gaccgcagcc agcccggcca ggactgccgc ttccgtgtca      360

cacaactgcc caacgggcgt gacttccaca tgagcgtggt cagggcccgg cgcaatgaca      420

gcggcaccta cctctgtggg gccatctccc tggcccccaa ggcgcagatc aaagagagcc      480

tgcgggcaga gctcagggtg acagagagaa gggcagaagt gcccacagcc caccccagcc      540

cctcacccag gccagccggc cagttccaaa ccctggtggt tggtgtcgtg ggcggcctgc      600

tgggcagcct ggtgctgcta gtctgggtcc tggccgtcat ctgctcccgg gccgcacgag      660

ggacaatagg agccaggcgc accggccagc ccctgaagga ggacccctca gccgtgcctg      720

tgttctctgt ggactatggg gagctggatt tccagtggcg agagaagacc ccggagcccc      780

ccgtgccctg tgtccctgag cagacggagt atgccaccat tgtctttcct agcggaatgg      840

gcacctcatc ccccgcccgc aggggctcag ctgacggccc tcggagtgcc cagccactga      900

ggcctgagga tggacactgc tcttggcccc tctgaccggc ttccttggcc accagtgttc      960

tgcagaccct ccaccatgag cccgggtcag cgcatttcct caggagaagc aggcagggtg     1020

caggccattg caggccgtcc aggggctgag ctgcctgggg gcgaccgggg ctccagcctg     1080

cacctgcacc aggcacagcc ccaccacagg actcatgtct caatgcccac agtgagccca     1140

ggcagcaggt gtcaccgtcc cctacaggga gggccagatg cagtcactgc ttcaggtcct     1200

gccagcacag agctgcctgc gtccagctcc ctgaatctct gctgctgctg ctgctgctgc     1260

tgctgctgcc tgcggcccgg ggctgaaggc gccgtggccc tgcctgacgc cccggagcct     1320

cctgcctgaa cttgggggct ggttggagat ggccttggag cagccaaggt gcccctggca     1380

gtggcatccc gaaacgccct ggacgcaggg cccaagactg ggcacaggag tgggaggtac     1440

atggggctgg ggactcccca ggagttatct gctccctgca ggcctagaga agtttcaggg     1500

aaggtcagaa gagctcctgg ctgtggtggg cagggcagga aacccctcca cctttacaca     1560

tgcccaggca gcacctcagg ccctttgtgg ggcagggaag ctgaggcagt aagcgggcag     1620

gcagagctgg aggcctttca ggcccagcca gcactctggc ctcctgccgc cgcattccac     1680

cccagcccct cacaccactc gggagaggga catcctacgg tcccaaggtc aggagggcag     1740

ggctggggtt gactcaggcc cctcccagct gtggccacct gggtgttggg agggcagaag     1800

tgcaggcacc tagggccccc catgtgccca ccctgggagc tctccttgga acccattcct     1860

gaaattattt aaaggggttg gccgggctcc caccagggcc tgggtgggaa ggtacaggcg     1920

ttcccccggg gcctagtacc cccgccgtgg cctatccact cctcacatcc acacactgca     1980

cccccactcc tggggcaggg ccaccagcat ccaggcggcc agcaggcacc tgagtggctg     2040

ggacaaggga tcccccttcc ctgtggttct attatattat aattataatt aaatatgaga     2100

gcatgctaag gaaaa                                                      2115


<210>  53
<211>  3451
<212>  DNA
<213>  Homo sapiens

<400>  53
cttcagatag attatatctg gagtgaagaa tcctgccacc tatgtatctg gcatagtctc       60

atctggccag aagagctgag acatccgttc ccctacaaga aactctcccc gggtggaaca      120

agatggatta tcaagtgtca agtccaatct atgacatcaa ttattataca tcggagccct      180

gccaaaaaat caatgtgaag caaatcgcag cccgcctcct gcctccgctc tactcactgg      240

tgttcatctt tggttttgtg ggcaacatgc tggtcatcct catcctgata aactgcaaaa      300

ggctgaagag catgactgac atctacctgc tcaacctggc catctctgac ctgtttttcc      360

ttcttactgt ccccttctgg gctcactatg ctgccgccca gtgggacttt ggaaatacaa      420

tgtgtcaact cttgacaggg ctctatttta taggcttctt ctctggaatc ttcttcatca      480

tcctcctgac aatcgatagg tacctggctg tcgtccatgc tgtgtttgct ttaaaagcca      540

ggacggtcac ctttggggtg gtgacaagtg tgatcacttg ggtggtggct gtgtttgcgt      600

ctctcccagg aatcatcttt accagatctc aaaaagaagg tcttcattac acctgcagct      660

ctcattttcc atacagtcag tatcaattct ggaagaattt ccagacatta aagatagtca      720

tcttggggct ggtcctgccg ctgcttgtca tggtcatctg ctactcggga atcctaaaaa      780

ctctgcttcg gtgtcgaaat gagaagaaga ggcacagggc tgtgaggctt atcttcacca      840

tcatgattgt ttattttctc ttctgggctc cctacaacat tgtccttctc ctgaacacct      900

tccaggaatt ctttggcctg aataattgca gtagctctaa caggttggac caagctatgc      960

aggtgacaga gactcttggg atgacgcact gctgcatcaa ccccatcatc tatgcctttg     1020

tcggggagaa gttcagaaac tacctcttag tcttcttcca aaagcacatt gccaaacgct     1080

tctgcaaatg ctgttctatt ttccagcaag aggctcccga gcgagcaagc tcagtttaca     1140

cccgatccac tggggagcag gaaatatctg tgggcttgtg acacggactc aagtgggctg     1200

gtgacccagt cagagttgtg cacatggctt agttttcata cacagcctgg gctgggggtg     1260

gggtgggaga ggtctttttt aaaaggaagt tactgttata gagggtctaa gattcatcca     1320

tttatttggc atctgtttaa agtagattag atcttttaag cccatcaatt atagaaagcc     1380

aaatcaaaat atgttgatga aaaatagcaa cctttttatc tccccttcac atgcatcaag     1440

ttattgacaa actctccctt cactccgaaa gttccttatg tatatttaaa agaaagcctc     1500

agagaattgc tgattcttga gtttagtgat ctgaacagaa ataccaaaat tatttcagaa     1560

atgtacaact ttttacctag tacaaggcaa catataggtt gtaaatgtgt ttaaaacagg     1620

tctttgtctt gctatgggga gaaaagacat gaatatgatt agtaaagaaa tgacactttt     1680

catgtgtgat ttcccctcca aggtatggtt aataagtttc actgacttag aaccaggcga     1740

gagacttgtg gcctgggaga gctggggaag cttcttaaat gagaaggaat ttgagttgga     1800

tcatctattg ctggcaaaga cagaagcctc actgcaagca ctgcatgggc aagcttggct     1860

gtagaaggag acagagctgg ttgggaagac atggggagga aggacaaggc tagatcatga     1920

agaaccttga cggcattgct ccgtctaagt catgagctga gcagggagat cctggttggt     1980

gttgcagaag gtttactctg tggccaaagg agggtcagga aggatgagca tttagggcaa     2040

ggagaccacc aacagccctc aggtcagggt gaggatggcc tctgctaagc tcaaggcgtg     2100

aggatgggaa ggagggaggt attcgtaagg atgggaagga gggaggtatt cgtgcagcat     2160

atgaggatgc agagtcagca gaactggggt ggatttgggt tggaagtgag ggtcagagag     2220

gagtcagaga gaatccctag tcttcaagca gattggagaa acccttgaaa agacatcaag     2280

cacagaagga ggaggaggag gtttaggtca agaagaagat ggattggtgt aaaaggatgg     2340

gtctggtttg cagagcttga acacagtctc acccagactc caggctgtct ttcactgaat     2400

gcttctgact tcatagattt ccttcccatc ccagctgaaa tactgagggg tctccaggag     2460

gagactagat ttatgaatac acgaggtatg aggtctagga acatacttca gctcacacat     2520

gagatctagg tgaggattga ttacctagta gtcatttcat gggttgttgg gaggattcta     2580

tgaggcaacc acaggcagca tttagcacat actacacatt caataagcat caaactctta     2640

gttactcatt cagggatagc actgagcaaa gcattgagca aaggggtccc atagaggtga     2700

gggaagcctg aaaaactaag atgctgcctg cccagtgcac acaagtgtag gtatcatttt     2760

ctgcatttaa ccgtcaatag gcaaaggggg gaagggacat attcatttgg aaataagctg     2820

ccttgagcct taaaacccac aaaagtacaa tttaccagcc tccgtatttc agactgaatg     2880

ggggtggggg gggcgcctta ggtacttatt ccagatgcct tctccagaca aaccagaagc     2940

aacagaaaaa atcgtctctc cctccctttg aaatgaatat accccttagt gtttgggtat     3000

attcatttca aagggagaga gagaggtttt tttctgttct gtctcatatg attgtgcaca     3060

tacttgagac tgttttgaat ttgggggatg gctaaaacca tcatagtaca ggtaaggtga     3120

gggaatagta agtggtgaga actactcagg gaatgaaggt gtcagaataa taagaggtgc     3180

tactgacttt ctcagcctct gaatatgaac ggtgagcatt gtggctgtca gcaggaagca     3240

acgaagggaa atgtctttcc ttttgctctt aagttgtgga gagtgcaaca gtagcatagg     3300

accctaccct ctgggccaag tcaaagacat tctgacatct tagtatttgc atattcttat     3360

gtatgtgaaa gttacaaatt gcttgaaaga aaatatgcat ctaataaaaa acaccttcta     3420

aaataaaaaa aaaaaaaaaa aaaaaaaaaa a                                    3451


<210>  54
<211>  1223
<212>  DNA
<213>  Homo sapiens

<400>  54
tgcagagatg aataaacaaa gaggaacctt ctcagaagtg agtctggccc aggacccaaa       60

gcggcagcaa aggaaaccta aaggcaataa aagctccatt tcaggaaccg aacaggaaat      120

attccaagta gaattaaatc ttcaaaatcc ttccctgaat catcaaggga ttgataaaat      180

atatgactgc caaggtttac tgccacctcc agagaagctc actgccgagg tcctaggaat      240

catttgcatt gtcctgatgg ccactgtgtt aaaaacaata gttcttattc ctttcctgga      300

gcagaacaat ttttccccga atacaagaac gcagaaagca cgtcattgtg gccattgtcc      360

tgaggagtgg attacatatt ccaacagttg ttattacatt ggtaaggaaa gaagaacttg      420

ggaagagagt ttgctggcct gtacttcgaa gaactccagt ctgctttcta tagataatga      480

agaagaaatg aaatttctgg ccagcatttt accttcctca tggattggtg tgtttcgtaa      540

cagcagtcat catccatggg tgacaataaa tggtttggct ttcaaacata agataaaaga      600

ctcagataat gctgaactta actgtgcagt gctacaagta aatcgactta aatcagccca      660

gtgtggatct tcaatgatat atcattgtaa gcataagctt tagaagtaaa gcatttgcgt      720

ttgcagtgca tcagatacat tttatatttc ttaaaataga aatattatga ttgcataaat      780

ctgaaaatga attatgttat ttgctctgat acaaaaattc taaatcaatt attgaaatag      840

gatgcacaca attactaaag tacagacatc ctagcatttg tgtcgggctc attttgctca      900

acatggtatt tgtggttttc agcctttcta aaagttgcat gttatgtgag tcagcttata      960

ggaagtacca agaacagtca aacccatgga gacagaaagt agaatagtgg ttgccaatgt     1020

ctcagggagg ttgaaatagg agatgaccac taattgatag aacgtttctt tgtgtcgtga     1080

tgaaaacttt ctaaatttca gtagtggtga tggttgtaac tctgcgaata tactaaacat     1140

cattgatttt taatcatttt aagtgcatga aatgtatgct ttgtacatga cacttcaata     1200

aagctatcca gaaaaaaaaa aaa                                             1223


<210>  55
<211>  3177
<212>  DNA
<213>  Homo sapiens

<400>  55
ctctgtaaaa taaatgcgct gggccggatc ttttctgagt tctcttctcc cctacgaatt       60

ctagatccct cctctgtcct ccctgcgcca gggaccttcg ggcgaccctt ccctgtaccc      120

ccaccccacc ctctctggac cccgtttctg cctcagtacg gcgcgctgag ctctgccccc      180

tgcccaggcc ctgaccccct caggagccgc ggtttcctgg ggtaacagtg ggaaacgtgt      240

cggccgtctc cgctcaggcg cttgctgtgt acagaaaggc tgattcaggc acaccggctc      300

tcgtcgcctt ggtggccctc cccagccctc ctccgcgcct gctccgggtg gcgctccgct      360

gggctcctcg tgcgcctgtc cgcgaccgca cccacctcat cctggcaccc ccatcgtggc      420

atcacgtgtt ccctcatctg tcctcatggc tggcgtgccc ctctgcggtg agacctgcag      480

aacaggaatt ggtgccgggt cagcagccgg cgatgaagcc ggacgaagcc tgcaaacccc      540

acccatacgc cagcttcaca tagctcctat ccattgcaca gcagcgtggg gaagcaccgt      600

tctctaccct ccaaacaaaa gcatgaacca ggtgcagtgg ctcacgtctg taatcccagc      660

attttggagg ccaaggtgga tggatggatt ccttgagtcc aggagttcaa gaccagcctg      720

ggcaacatgg tgaaccccca tctctacaaa aatttagcca gttttcagct gcccccagtt      780

gcctggccag gctgcctcga cggccctatt cacgggcccc agcctcctcg ccgggctgga      840

aggcgacaac cgcgaaaagg agggtgactc tcctcggcgg gggcttcggg tgacatcaca      900

tcctccaaat gcgaaatcag gctccgggcc ggccgaaggg cgcaactttc ccccctcggc      960

gccccaccgg ctcccgcgcg cctcccctcg cgcccgagct tcgagccaag cagcgtcctg     1020

gggagcgcgt catggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc     1080

acgccgccag gccgagccag ttccgggtgt cgccgctgga tcggacctgg aacctgggcg     1140

agacagtgga gctgaagtgc caggtgctgc tgtccaaccc gacgtcgggc tgctcgtggc     1200

tcttccagcc gcgcggcgcc gccgccagtc ccaccttcct cctatacctc tcccaaaaca     1260

agcccaaggc ggccgagggg ctggacaccc agcggttctc gggcaagagg ttgggggaca     1320

ccttcgtcct caccctgagc gacttccgcc gagagaacga gggctactat ttctgctcgg     1380

ccctgagcaa ctccatcatg tacttcagcc acttcgtgcc ggtcttcctg ccagcgaagc     1440

ccaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc     1500

tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac acgagggggc     1560

tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt ggggtccttc     1620

tcctgtcact ggttatcacc ctttactgca accacaggaa ccgaagacgt gtttgcaaat     1680

gtccccggcc tgtggtcaaa tcgggagaca agcccagcct ttcggcgaga tacgtctaac     1740

cctgtgcaac agccactaca ttacttcaaa ctgagatcct tccttttgag ggagcaagtc     1800

cttccctttc attttttcca gtcttcctcc ctgtgtattc attctcatga ttattatttt     1860

agtgggggcg gggtgggaaa gattactttt tctttatgtg tttgacggga aacaaaacta     1920

ggtaaaatct acagtacacc acaagggtca caatactgtt gtgcgcacat cgcggtaggg     1980

cgtggaaagg ggcaggccag agctacccgc agagttctca gaatcatgct gagagagctg     2040

gaggcaccca tgccatctca acctcttccc cgcccgtttt acaaaggggg aggctaaagc     2100

ccagagacag cttgatcaaa ggcacacagc aagtcagggt tggagcagta gctggaggga     2160

ccttgtctcc cagctcaggg ctctttcctc cacaccattc aggtctttct ttccgaggcc     2220

cctgtctcag ggtgaggtgc ttgagtctcc aacggcaagg gaacaagtac ttcttgatac     2280

ctgggatact gtgcccagag cctcgaggag gtaatgaatt aaagaagaga actgcctttg     2340

gcagagttct ataatgtaaa caatatcaga cttttttttt ttataatcaa gcctaaaatt     2400

gtatagacct aaaataaaat gaagtggtga gcttaaccct ggaaaatgaa tccctctatc     2460

tctaaagaaa atctctgtga aacccctatg tggaggcgga attgctctcc cagcccttgc     2520

attgcagagg ggcccatgaa agaggacagg ctaccccttt acaaatagaa tttgagcatc     2580

agtgaggtta aactaaggcc ctcttgaatc tctgaatttg agatacaaac atgttcctgg     2640

gatcactgat gactttttat actttgtaaa gacaattgtt ggagagcccc tcacacagcc     2700

ctggcctctg ctcaactagc agatacaggg atgaggcaga cctgactctc ttaaggaggc     2760

tgagagccca aactgctgtc ccaaacatgc acttccttgc ttaaggtatg gtacaagcaa     2820

tgcctgccca ttggagagaa aaaacttaag tagataagga aataagaacc actcataatt     2880

cttcacctta ggaataatct cctgttaata tggtgtacat tcttcctgat tattttctac     2940

acatacatgt aaaatatgtc tttctttttt aaatagggtt gtactatgct gttatgagtg     3000

gctttaatga ataaacattt gtagcatcct ctttaatggg taaacagcat ccgaaaaaaa     3060

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa        3177


<210>  56
<211>  6001
<212>  DNA
<213>  Homo sapiens

<400>  56
caaggaggga tcccacagat gtcacagggc tgtcacagag ctgtggtggg aatttcccat       60

gagaccccgc ccctggctga gtcaccgcac tcctgtgttt gacctgaagt cctctcgagc      120

tgcagaagcc tgaagaccaa ggagtggaaa gttctccggc agccctgaga tctcaagagt      180

gacatttgtg agaccagcta atttgattaa aattctcttg gaatcagctt tgctagtatc      240

atacctgtgc cagatttcat catgggaaac agctgttaca acatagtagc cactctgttg      300

ctggtcctca actttgagag gacaagatca ttgcaggatc cttgtagtaa ctgcccagct      360

ggtacattct gtgataataa caggaatcag atttgcagtc cctgtcctcc aaatagtttc      420

tccagcgcag gtggacaaag gacctgtgac atatgcaggc agtgtaaagg tgttttcagg      480

accaggaagg agtgttcctc caccagcaat gcagagtgtg actgcactcc agggtttcac      540

tgcctggggg caggatgcag catgtgtgaa caggattgta aacaaggtca agaactgaca      600

aaaaaaggtt gtaaagactg ttgctttggg acatttaacg atcagaaacg tggcatctgt      660

cgaccctgga caaactgttc tttggatgga aagtctgtgc ttgtgaatgg gacgaaggag      720

agggacgtgg tctgtggacc atctccagcc gacctctctc cgggagcatc ctctgtgacc      780

ccgcctgccc ctgcgagaga gccaggacac tctccgcaga tcatctcctt ctttcttgcg      840

ctgacgtcga ctgcgttgct cttcctgctg ttcttcctca cgctccgttt ctctgttgtt      900

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa      960

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     1020

gaactgtgaa atggaagtca atagggctgt tgggactttc ttgaaaagaa gcaaggaaat     1080

atgagtcatc cgctatcaca gctttcaaaa gcaagaacac catcctacat aatacccagg     1140

attcccccaa cacacgttct tttctaaatg ccaatgagtt ggcctttaaa aatgcaccac     1200

tttttttttt tttttgacag ggtctcactc tgtcacccag gctggagtgc agtggcacca     1260

ccatggctct ctgcagcctt gacctctggg agctcaagtg atcctcctgc ctcagtctcc     1320

tgagtagctg gaactacaag gaagggccac cacacctgac taactttttt gttttttgtt     1380

tggtaaagat ggcatttcac catgttgtac aggctggtct caaactccta ggttcacttt     1440

ggcctcccaa agtgctggga ttacagacat gaactgccag gcccggccaa aataatgcac     1500

cacttttaac agaacagaca gatgaggaca gagctggtga taaaaaaaaa aaaaaaaaag     1560

cattttctag ataccactta acaggtttga gctagttttt ttgaaatcca aagaaaatta     1620

tagtttaaat tcaattacat agtccagtgg tccaactata attataatca aaatcaatgc     1680

aggtttgttt tttggtgcta atatgacata tgacaataag ccacgaggtg cagtaagtac     1740

ccgactaaag tttccgtggg ttctgtcatg taacacgaca tgctccaccg tcagggggga     1800

gtatgagcag agtgcctgag tttagggtca aggacaaaaa acctcaggcc tggaggaagt     1860

tttggaaaga gttcaagtgt ctgtatatcc tatggtcttc tccatcctca caccttctgc     1920

ctttgtcctg ctccctttta agccaggtta cattctaaaa attcttaact tttaacataa     1980

tattttatac caaagccaat aaatgaactg catatgatag gtatgaagta cagtgagaaa     2040

attaacacct gtgagctcat tgtcctacca cagcactaga gtgggggccg ccaaactccc     2100

atggccaaac ctggtgcacc atttgccttt gtttgtctgt tggtttgctt gagacagtct     2160

tgctctgttg cccaggctgg aatggagtgg ctattcacag gcacaatcat agcacacttt     2220

agccttaaac tcctgggctc aagtgatcca cccgcctcag tctcccaagt agctgggatt     2280

acaggtgcaa acctggcatg cctgccattg tttggcttat gatctaagga tagcttttta     2340

aattttattc attttatttt tttttgagac agtgtctcac tctgtctccc aggctggagt     2400

acagtggtac aatcttggat caccgcctcc cagtttcaag tgatctccct gcctcagcct     2460

cctaagtagc tgggactaca ggtatgtgcc accacgcctg gctaattttt atatttttag     2520

tagagacggg gtttcaccat gttgtccagg ctggtctcaa actcctgacc tcaggtgatc     2580

tgcccacctc tgcctcccaa agtgctggga ttacaggcat gagccaccat gcctggccat     2640

ttcttacact tttgtatgac atgcctattg caagcttgcg tgcctctgtc ccatgttatt     2700

ttactctggg atttaggtgg agggagcagc ttctatttgg aacattggcc atcgcatggc     2760

aaatgggtat ctgtcacttc tgctcctatt tagttggttc tactataacc tttagagcaa     2820

atcctgcagc caagccaggc atcaataggg cagaaaagta tattctgtaa ataggggtga     2880

ggagaagata tttctgaaca atagtctact gcagtaccaa attgcttttc aaagtggctg     2940

ttctaatgta ctcccgtcag tcatataagt gtcatgtaag tatcccattg atccacatcc     3000

ttgctaccct ctggtactat caggtgccct taattttgcc aagccagtgg gtatagaatg     3060

agatctcact gtggtcttag tttgcatttg cttggttact gatgagcacc ttgtcaaata     3120

tttatatacc atttgtgttt atttttttaa ataaaatgct tgctcatgct tttttgccca     3180

tttgcaaaaa aacttggggc cgggtgcagt ggctcatgcc tgtagtccca gctctttggg     3240

aggccaaggt gggcagatcg cttgagccca ggagttcgag accagccttg gcaacatggc     3300

gaaaccctgt ctttacaaaa aatacaaaaa ttagccgggt gtggtggtgt gcacctgaag     3360

tcccagctac tcagtaggtt cgctttgagc ctgggaggca gaggttgcag tgagctggga     3420

ccgcatcact acacttcagc ctgggcaaca gagaaaaacc ttttctcaga aacaaacaaa     3480

cccaaatgtg gttgtttgtc ctgattccta aaaggtcttt atgtattcta gataataatc     3540

tttggtcagt tatatgtgtt aaaaaatatc ttctttgtgg ccaggcacgg tagctcacac     3600

ctgtaatccc agcactttgc ggggctgagg tgggtggatc atctgaggtc aagagttcaa     3660

gatcagcctg gccaacacag tgaaacccca tctctactaa acatgtacaa aacttagctg     3720

ggtatggtgg cgggtgcctg taaccccagc tgctccagag gctgtggcag aagaatcgct     3780

tgaacccagg aggcagaggt tgcagcgagc caagattgtg ccattgcact ccagactggg     3840

tgacaagagt gaaattctgc ctatctatct atctatctat ctatatctat atatatatat     3900

atatatatcc tttgtaattt atttttccct ttttaaaatt ttttataaaa ttctttttta     3960

tttttatttt tagcagaggt gaggtttctg aggtttcatt atgttgccca ggctggtctt     4020

gaactcctga gctcaagtga tcctcccacc tcagccttcc aaagtgctgg aattgcagac     4080

atgagccacc gcgcccctcc tgtttttctc taattaatgg tgtctttctt tgtctttctg     4140

gtaataagca aaaagttctt catttgattt ggttaaattt ataactgttt tctcatatgg     4200

ttaacatttt ttcttgcctg gctaaagaaa tccttttctg cccaatacta taaagaggtt     4260

tgcccacatt ttattccaaa agttttaagt tttgtctttc atcttgaagt ctaatgtatc     4320

aggaactggc ttttgtgcct gttgggaggt agtgatccaa ttccatgtct tgcatgtagg     4380

taaccactgg tccctgcgcc atgtattcaa tacgtcgtct ttctcctgcg ggtctgcaat     4440

ctcacctacc atccatcaag tttccatagg gccatgggtc tgcttctggg ctccctgttc     4500

tgttccattg tcaatttgtc tatcctgtgc cagtatcaca ctgtgtttat tacaatagct     4560

ttgtaacagc tctcgatatc cggtaggaca tctccctcca ccttcttttt ctacttcaga     4620

agtgtcttag ctaggtcagg cacggtggct cacgcctgta atcccagcac tttgggaggc     4680

cgacgcggat ggatcacctg aggtcaggag ttttgagaca gcctggccaa catggtgaaa     4740

ccccatctct actaaaaaat acaaaaatta gtcaggcatg gtggcatgtg cctgtaatcc     4800

cagctatttg ggaggctgag gccggagaat tgcttgaacc cggggggcgg aggttgcagt     4860

gagccgagat cgtaccattg cactccagcc tgggtgacag agcgaaactc tgtctcagga     4920

aaaaaaagaa aagagatgtc ttggttattc ttggttcttt attattcaat ataaatttta     4980

gaagctgaat ttgaaaagat ttggattgga atttcattaa atctacaggt caatttaggg     5040

agagttgata attttacaga attgagtcat ctggtgttcc aataagaata agagaacaat     5100

tattggctgt acaattcttg ccaaatagta ggcaaagcaa agcttaggaa gtatactggt     5160

gccatttcag gaacaaagct aggtgcgaat atttttgtct ttctgaatca tgatgctgta     5220

agttctaaag tgatttctcc tcttggcttt ggacacatgg tgtttaatta cctactgctg     5280

actatccaca aacagaaaga gactggtcat gccccacagg gttggggtat ccaagataat     5340

ggagcgaggc tctcatgtgt cctaggttac acaccgaaaa tccacagttt attctgtgaa     5400

gaaaggaggc tatgtttatg atacagactg tgatattttt atcatagcct attctggtat     5460

catgtgcaaa agctataaat gaaaaacaca ggaacttggc atgtgagtca ttgctccccc     5520

taaatgacaa ttaataagga aggaacattg agacagaata aaatgatccc cttctgggtt     5580

taatttagaa agttccataa ttaggtttaa tagaaataaa tgtaaatttc tatgattaaa     5640

aataaattag cacatttagg gatacacaaa ttataaatca ttttctaaat gctaaaaaca     5700

agctcaggtt tttttcagaa gaaagtttta attttttttc tttagtggaa gatatcactc     5760

tgacggaaag ttttgatgtg aggggcggat gactataaag tgggcatctt cccccacagg     5820

aagatgtttc catctgtggg tgagaggtgc ccaccgcagc tagggcaggt tacatgtgcc     5880

ctgtgtgtgg taggacttgg agagtgatct ttatcaacgt ttttatttaa aagactatct     5940

aataaaacac aaaactatga tgttcacagg aaaaaaagaa taagaaaaaa agaaaaaaaa     6000

a                                                                     6001


