                         SEQUENCE LISTING

<110>  Jounce Therapeutics, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

<130>  01140-0007-00PCT

<150>  US 62/481,025
<151>  2017-04-03

<150>  US 62/514,591
<151>  2017-06-02

<160>  216   

<170>  PatentIn version 3.5

<210>  1
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  2
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys 
            20                  25                  30          


Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His 
    50                  55                  60                  


Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp 
65                  70                  75                  80  


His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu 
            100                 105                 110         


Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro Ile Gly Cys Ala 
        115                 120                 125             


Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu 
    130                 135                 140                 


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
145                 150                 155                 160 


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
                165                 170                 175     


Val Thr Leu 
            


<210>  3
<211>  200
<212>  PRT
<213>  Mus musculus

<400>  3

Met Lys Pro Tyr Phe Cys Arg Val Phe Val Phe Cys Phe Leu Ile Arg 
1               5                   10                  15      


Leu Leu Thr Gly Glu Ile Asn Gly Ser Ala Asp His Arg Met Phe Ser 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Ser Cys Lys Tyr Pro Glu Thr Val 
        35                  40                  45              


Gln Gln Leu Lys Met Arg Leu Phe Arg Glu Arg Glu Val Leu Cys Glu 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Ala Val Ser Ile Lys Asn Pro 
65                  70                  75                  80  


Met Leu Cys Leu Tyr His Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Asn Asn Pro Asp Ser Ser Gln Gly Ser Tyr Tyr Phe Cys Ser Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Gln Glu Arg Asn Leu Ser Gly Gly Tyr 
        115                 120                 125             


Leu His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Trp Leu 
    130                 135                 140                 


Pro Val Gly Cys Ala Ala Phe Val Val Val Leu Leu Phe Gly Cys Ile 
145                 150                 155                 160 


Leu Ile Ile Trp Phe Ser Lys Lys Lys Tyr Gly Ser Ser Val His Asp 
                165                 170                 175     


Pro Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr Asn Lys Lys 
            180                 185                 190         


Ser Arg Leu Ala Gly Val Thr Ser 
        195                 200 


<210>  4
<211>  180
<212>  PRT
<213>  Mus musculus

<400>  4

Glu Ile Asn Gly Ser Ala Asp His Arg Met Phe Ser Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Ser Cys Lys Tyr Pro Glu Thr Val Gln Gln Leu Lys 
            20                  25                  30          


Met Arg Leu Phe Arg Glu Arg Glu Val Leu Cys Glu Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Ala Val Ser Ile Lys Asn Pro Met Leu Cys Leu 
    50                  55                  60                  


Tyr His Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Asn Asn Pro Asp 
65                  70                  75                  80  


Ser Ser Gln Gly Ser Tyr Tyr Phe Cys Ser Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Gln Glu Arg Asn Leu Ser Gly Gly Tyr Leu His Ile Tyr 
            100                 105                 110         


Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Trp Leu Pro Val Gly Cys 
        115                 120                 125             


Ala Ala Phe Val Val Val Leu Leu Phe Gly Cys Ile Leu Ile Ile Trp 
    130                 135                 140                 


Phe Ser Lys Lys Lys Tyr Gly Ser Ser Val His Asp Pro Asn Ser Glu 
145                 150                 155                 160 


Tyr Met Phe Met Ala Ala Val Asn Thr Asn Lys Lys Ser Arg Leu Ala 
                165                 170                 175     


Gly Val Thr Ser 
            180 


<210>  5
<211>  199
<212>  PRT
<213>  Macaca fascicularis

<400>  5

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu His Met Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Lys Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp Arg Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Thr Phe Val Val Val Cys Ile Phe Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Thr Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Gly Thr Thr Pro 
        195                 


<210>  6
<211>  179
<212>  PRT
<213>  Macaca fascicularis

<400>  6

Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys 
            20                  25                  30          


Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Lys Val Ser Ile Lys Ser Leu Lys Phe Cys His 
    50                  55                  60                  


Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp 
65                  70                  75                  80  


Arg Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu 
            100                 105                 110         


Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro Ile Gly Cys Ala 
        115                 120                 125             


Thr Phe Val Val Val Cys Ile Phe Gly Cys Ile Leu Ile Cys Trp Leu 
    130                 135                 140                 


Thr Lys Lys Lys Tyr Ser Ser Thr Val His Asp Pro Asn Gly Glu Tyr 
145                 150                 155                 160 


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Gly 
                165                 170                 175     


Thr Thr Pro 
            


<210>  7

<400>  7
000

<210>  8

<400>  8
000

<210>  9

<400>  9
000

<210>  10

<400>  10
000

<210>  11

<400>  11
000

<210>  12

<400>  12
000

<210>  13

<400>  13
000

<210>  14

<400>  14
000

<210>  15

<400>  15
000

<210>  16

<400>  16
000

<210>  17

<400>  17
000

<210>  18

<400>  18
000

<210>  19

<400>  19
000

<210>  20
<211>  117
<212>  PRT
<213>  Mesocricetus auratus

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Val Lys Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Arg Phe Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  21
<211>  111
<212>  PRT
<213>  Mesocricetus auratus

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Gly 
            20                  25                  30          


Ser Phe Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Thr Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Tyr Ala Ser Thr Arg His Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Met Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Ser Phe Gln Thr Glu Asp Leu Gly Asp Tyr Tyr Cys His His His Tyr 
                85                  90                  95      


Asn Ala Pro Pro Thr Phe Gly Pro Gly Thr Lys Leu Glu Leu Arg 
            100                 105                 110     


<210>  22
<211>  10
<212>  PRT
<213>  Mesocricetus auratus

<400>  22

Gly Phe Thr Phe Ser Asp Tyr Trp Met Asp 
1               5                   10  


<210>  23
<211>  17
<212>  PRT
<213>  Mesocricetus auratus

<400>  23

Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  8
<212>  PRT
<213>  Mesocricetus auratus

<400>  24

Trp Gly Arg Phe Gly Phe Asp Ser 
1               5               


<210>  25
<211>  15
<212>  PRT
<213>  Mesocricetus auratus

<400>  25

Lys Ser Ser Gln Ser Leu Leu Ser Gly Ser Phe Asn Tyr Leu Thr 
1               5                   10                  15  


<210>  26
<211>  7
<212>  PRT
<213>  Mesocricetus auratus

<400>  26

Tyr Ala Ser Thr Arg His Thr 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  Mesocricetus auratus

<400>  27

His His His Tyr Asn Ala Pro Pro Thr 
1               5                   


<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35

<400>  35
000

<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38

<400>  38
000

<210>  39

<400>  39
000

<210>  40

<400>  40
000

<210>  41

<400>  41
000

<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45

<400>  45
000

<210>  46

<400>  46
000

<210>  47

<400>  47
000

<210>  48

<400>  48
000

<210>  49

<400>  49
000

<210>  50

<400>  50
000

<210>  51

<400>  51
000

<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55

<400>  55
000

<210>  56

<400>  56
000

<210>  57

<400>  57
000

<210>  58

<400>  58
000

<210>  59

<400>  59
000

<210>  60
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S713 heavy chain variable region

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Arg Phe Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  61
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S713 light chain variable region

<400>  61

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Gly 
            20                  25                  30          


Ser Phe Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Tyr Ala Ser Thr Arg His Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His His His Tyr 
                85                  90                  95      


Asn Ala Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S713 VH CDR1

<400>  62

Gly Phe Thr Phe Ser Asp Tyr Trp Met Asp 
1               5                   10  


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S713 VH CDR2

<400>  63

Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S713 VH CDR3

<400>  64

Trp Gly Arg Phe Gly Phe Asp Ser 
1               5               


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S713 VL CDR1

<400>  65

Lys Ser Ser Gln Ser Leu Leu Ser Gly Ser Phe Asn Tyr Leu Thr 
1               5                   10                  15  


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S713 VL CDR2

<400>  66

Tyr Ala Ser Thr Arg His Thr 
1               5           


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S713 VL CDR3

<400>  67

His His His Tyr Asn Ala Pro Pro Thr 
1               5                   


<210>  68

<400>  68
000

<210>  69

<400>  69
000

<210>  70
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S714 heavy chain variable region

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Arg Phe Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  71
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S714 light chain variable region

<400>  71

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Gly 
            20                  25                  30          


Ser Phe Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Tyr Ala Ser Thr Arg Glu Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His His His Tyr 
                85                  90                  95      


Asn Ala Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S714 VH CDR1

<400>  72

Gly Phe Thr Phe Ser Asp Tyr Trp Met Asp 
1               5                   10  


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S714 VH CDR2

<400>  73

Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S714 VH CDR3

<400>  74

Trp Gly Arg Phe Gly Phe Asp Ser 
1               5               


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S714 VL CDR1

<400>  75

Lys Ser Ser Gln Ser Leu Leu Ser Gly Ser Phe Asn Tyr Leu Thr 
1               5                   10                  15  


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S714 VL CDR2

<400>  76

Tyr Ala Ser Thr Arg Glu Thr 
1               5           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S714 VL CDR3

<400>  77

His His His Tyr Asn Ala Pro Pro Thr 
1               5                   


<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S715 heavy chain variable region

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Arg Phe Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  81
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S715 light chain variable region

<400>  81

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Gly 
            20                  25                  30          


Ser Phe Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Tyr Ala Ser Thr Arg Gln Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His His His Tyr 
                85                  90                  95      


Asn Ala Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S715 VH CDR1

<400>  82

Gly Phe Thr Phe Ser Asp Tyr Trp Met Asp 
1               5                   10  


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S715 VH CDR2

<400>  83

Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S715 VH CDR3

<400>  84

Trp Gly Arg Phe Gly Phe Asp Ser 
1               5               


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S715 VL CDR1

<400>  85

Lys Ser Ser Gln Ser Leu Leu Ser Gly Ser Phe Asn Tyr Leu Thr 
1               5                   10                  15  


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S715 VL CDR2

<400>  86

Tyr Ala Ser Thr Arg Gln Thr 
1               5           


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S715 VL CDR3

<400>  87

His His His Tyr Asn Ala Pro Pro Thr 
1               5                   


<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S716 heavy chain variable region

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asn Ile Asp Glu Ser Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Arg Phe Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  91
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S716 light chain variable region

<400>  91

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Gly 
            20                  25                  30          


Ser Phe Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Tyr Ala Ser Thr Arg His Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His His His Tyr 
                85                  90                  95      


Asn Ala Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S716 VH CDR1

<400>  92

Gly Phe Thr Phe Ser Asp Tyr Trp Met Asp 
1               5                   10  


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S716 VH CDR2

<400>  93

Asn Ile Asp Glu Ser Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S716 VH CDR3

<400>  94

Trp Gly Arg Phe Gly Phe Asp Ser 
1               5               


<210>  95
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S716 VL CDR1

<400>  95

Lys Ser Ser Gln Ser Leu Leu Ser Gly Ser Phe Asn Tyr Leu Thr 
1               5                   10                  15  


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S716 VL CDR2

<400>  96

Tyr Ala Ser Thr Arg His Thr 
1               5           


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S716 VL CDR3

<400>  97

His His His Tyr Asn Ala Pro Pro Thr 
1               5                   


<210>  98

<400>  98
000

<210>  99

<400>  99
000

<210>  100
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S717 heavy chain variable region

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asn Ile Asp Glu Ser Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Arg Phe Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  101
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S717 light chain variable region

<400>  101

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Gly 
            20                  25                  30          


Ser Phe Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Tyr Ala Ser Thr Arg Glu Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His His His Tyr 
                85                  90                  95      


Asn Ala Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S717 VH CDR1

<400>  102

Gly Phe Thr Phe Ser Asp Tyr Trp Met Asp 
1               5                   10  


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S717 VH CDR2

<400>  103

Asn Ile Asp Glu Ser Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S717 VH CDR3

<400>  104

Trp Gly Arg Phe Gly Phe Asp Ser 
1               5               


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S717 VL CDR1

<400>  105

Lys Ser Ser Gln Ser Leu Leu Ser Gly Ser Phe Asn Tyr Leu Thr 
1               5                   10                  15  


<210>  106
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S717 VL CDR2

<400>  106

Tyr Ala Ser Thr Arg Glu Thr 
1               5           


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S717 VL CDR3

<400>  107

His His His Tyr Asn Ala Pro Pro Thr 
1               5                   


<210>  108

<400>  108
000

<210>  109

<400>  109
000

<210>  110
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S718 heavy chain variable region

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asn Ile Asp Glu Ser Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Arg Phe Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  111
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S718 light chain variable region

<400>  111

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser Gly 
            20                  25                  30          


Ser Phe Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Tyr Ala Ser Thr Arg Gln Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His His His Tyr 
                85                  90                  95      


Asn Ala Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S718 VH CDR1

<400>  112

Gly Phe Thr Phe Ser Asp Tyr Trp Met Asp 
1               5                   10  


<210>  113
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S718 VH CDR2

<400>  113

Asn Ile Asp Glu Ser Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S718 VH CDR3

<400>  114

Trp Gly Arg Phe Gly Phe Asp Ser 
1               5               


<210>  115
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S718 VL CDR1

<400>  115

Lys Ser Ser Gln Ser Leu Leu Ser Gly Ser Phe Asn Tyr Leu Thr 
1               5                   10                  15  


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S718 VL CDR2

<400>  116

Tyr Ala Ser Thr Arg Gln Thr 
1               5           


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S718 VL CDR3

<400>  117

His His His Tyr Asn Ala Pro Pro Thr 
1               5                   


<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121

<400>  121
000

<210>  122

<400>  122
000

<210>  123

<400>  123
000

<210>  124

<400>  124
000

<210>  125

<400>  125
000

<210>  126

<400>  126
000

<210>  127

<400>  127
000

<210>  128

<400>  128
000

<210>  129

<400>  129
000

<210>  130

<400>  130
000

<210>  131

<400>  131
000

<210>  132

<400>  132
000

<210>  133

<400>  133
000

<210>  134

<400>  134
000

<210>  135

<400>  135
000

<210>  136

<400>  136
000

<210>  137

<400>  137
000

<210>  138

<400>  138
000

<210>  139

<400>  139
000

<210>  140

<400>  140
000

<210>  141

<400>  141
000

<210>  142

<400>  142
000

<210>  143

<400>  143
000

<210>  144

<400>  144
000

<210>  145

<400>  145
000

<210>  146

<400>  146
000

<210>  147

<400>  147
000

<210>  148

<400>  148
000

<210>  149

<400>  149
000

<210>  150

<400>  150
000

<210>  151

<400>  151
000

<210>  152

<400>  152
000

<210>  153

<400>  153
000

<210>  154

<400>  154
000

<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173

<400>  173
000

<210>  174

<400>  174
000

<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S713 human IgG1 heavy chain

<400>  188

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Arg Phe Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  189
<211>  219
<212>  PRT
<213>  Artificial Sequenc

<220>
<223>  37A10S713 human kappa light chain

<400>  189

Glu Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Ser 
            20                  25                  30          


Gly Ser Phe Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Phe Tyr Ala Ser Thr Arg His Thr Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His His His 
                85                  90                  95      


Tyr Asn Ala Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  190
<211>  200
<212>  PRT
<213>  Rattus norvegicus

<400>  190

Met Lys Pro Tyr Phe Ser Cys Val Phe Val Phe Cys Phe Leu Ile Lys 
1               5                   10                  15      


Leu Leu Thr Gly Glu Leu Asn Asp Leu Ala Asn His Arg Met Phe Ser 
            20                  25                  30          


Phe His Asp Gly Gly Val Gln Ile Ser Cys Asn Tyr Pro Glu Thr Val 
        35                  40                  45              


Gln Gln Leu Lys Met Gln Leu Phe Lys Asp Arg Glu Val Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Asn Pro 
65                  70                  75                  80  


Met Ser Cys Pro Tyr Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Asp Asn Ala Asp Ser Ser Gln Gly Ser Tyr Phe Leu Cys Ser Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Gln Glu Lys Asn Leu Ser Gly Gly Tyr 
        115                 120                 125             


Leu Leu Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Trp Leu 
    130                 135                 140                 


Pro Val Gly Cys Ala Ala Phe Val Ala Ala Leu Leu Phe Gly Cys Ile 
145                 150                 155                 160 


Phe Ile Val Trp Phe Ala Lys Lys Lys Tyr Arg Ser Ser Val His Asp 
                165                 170                 175     


Pro Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr Asn Lys Lys 
            180                 185                 190         


Ser Arg Leu Ala Gly Met Thr Ser 
        195                 200 


<210>  191
<211>  180
<212>  PRT
<213>  Rattus norvegicus

<400>  191

Glu Leu Asn Asp Leu Ala Asn His Arg Met Phe Ser Phe His Asp Gly 
1               5                   10                  15      


Gly Val Gln Ile Ser Cys Asn Tyr Pro Glu Thr Val Gln Gln Leu Lys 
            20                  25                  30          


Met Gln Leu Phe Lys Asp Arg Glu Val Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Asn Pro Met Ser Cys Pro 
    50                  55                  60                  


Tyr Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Asp Asn Ala Asp 
65                  70                  75                  80  


Ser Ser Gln Gly Ser Tyr Phe Leu Cys Ser Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Gln Glu Lys Asn Leu Ser Gly Gly Tyr Leu Leu Ile Tyr 
            100                 105                 110         


Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Trp Leu Pro Val Gly Cys 
        115                 120                 125             


Ala Ala Phe Val Ala Ala Leu Leu Phe Gly Cys Ile Phe Ile Val Trp 
    130                 135                 140                 


Phe Ala Lys Lys Lys Tyr Arg Ser Ser Val His Asp Pro Asn Ser Glu 
145                 150                 155                 160 


Tyr Met Phe Met Ala Ala Val Asn Thr Asn Lys Lys Ser Arg Leu Ala 
                165                 170                 175     


Gly Met Thr Ser 
            180 


<210>  192
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M13 heavy chain variable region

<400>  192

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Val Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asp Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Gln Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asn Ala Val Tyr Asp Pro Gln Phe 
    50                  55                  60                  


Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asp Tyr Tyr Gly Ser Lys Gly Tyr Leu Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  193
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M13 light chain variable region

<400>  193

Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Gly Gly Ser 
    50                  55                  60                  


Arg Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  194
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M13 VH CDR1

<400>  194

Asp Tyr Tyr Met His 
1               5   


<210>  195
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M13 VH CDR2

<400>  195

Trp Ile Asp Pro Glu Asn Gly Asn Ala Val Tyr Asp Pro Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  196
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M13 VH CDR3

<400>  196

Asp Tyr Tyr Gly Ser Lys Gly Tyr Leu Asp Val 
1               5                   10      


<210>  197
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M13 VL CDR1

<400>  197

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M13 VL CDR2

<400>  198

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  199
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M13 VL CDR3

<400>  199

Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  200
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M19 heavy chain variable region

<400>  200

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Thr Ser Ala Phe Asn Ile Ile Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Ile Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Asp Pro Glu Asn Gly Asp Pro Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Met Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Trp Arg Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  201
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M19 light chain variable region

<400>  201

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Ile His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  202
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M19 VH CDR1

<400>  202

Asp Tyr Tyr Met His 
1               5   


<210>  203
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M19 VH CDR2

<400>  203

Trp Ile Asp Pro Glu Asn Gly Asp Pro Glu Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  204
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M19 VH CDR3

<400>  204

Trp Arg Gly Phe Ala Tyr 
1               5       


<210>  205
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M19 VL CDR1

<400>  205

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  206
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M19 VL CDR2

<400>  206

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M19 VL CDR3

<400>  207

Ser Gln Ser Ile His Val Pro Pro Thr 
1               5                   


<210>  208
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M24 heavy chain variable region

<400>  208

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Arg Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Ile Asp Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Phe 
                85                  90                  95      


Thr Ala Trp Lys Gly Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  209
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M24 light chain variable region

<400>  209

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Met Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  210
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M24 VH CDR1

<400>  210

Asp Tyr Tyr Met His 
1               5   


<210>  211
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M24 VH CDR2

<400>  211

Trp Ile Asp Pro Glu Asn Gly Asp Ile Asp Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  212
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M24 VH CDR3

<400>  212

Trp Lys Gly Leu Ala Tyr 
1               5       


<210>  213
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M24 VL CDR1

<400>  213

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu Gln 
1               5                   10                  15      


<210>  214
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M24 VL CDR2

<400>  214

Lys Val Phe Asn Arg Phe Ser 
1               5           


<210>  215
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2M24 VL CDR3

<400>  215

Ser Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  216
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A10S713 human IgG1 heavy chain V2

<400>  216

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Asn Ile Asp Glu Asp Gly Ser Ile Thr Glu Tyr Ser Pro Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Gly Arg Phe Gly Phe Asp Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


