                         SEQUENCE LISTING

<110>  Universitt Stuttgart
 
<120>  Tumor Necrosis Factor Receptor (TNFR) Binding Protein Complex With 
       Improved Binding and Bioactivity

<130>  762-6 PCT

<160>  100   

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can be S, T. or V

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  can be F, Y, or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can be A, L, V, or I

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  can be F, V, Q, A, I, L, or Y

<400>  1

Xaa Xaa Phe Gly Xaa Xaa 
1               5       


<210>  2
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can  be P, K, V, I, or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  can  be V, A, or F

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can  be V, L, I, Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can  be V, L, I, or Y

<400>  2

Xaa Xaa Ala His Xaa 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can be D, S, M, or I

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  can be V, W, F or C

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  can be A or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  can be E, Y, Q, or H

<400>  3

Xaa Xaa Xaa Xaa Leu 
1               5   


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  4

Gly Gly Gly Gly 
1               


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  5

Gly Gly Gly Gly Gly 
1               5   


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  6

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  7

Ser Gly Gly Gly 
1               


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  8

Gly Ser Gly Gly 
1               


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  9

Gly Gly Ser Gly 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  10

Gly Gly Gly Ser 
1               


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  11

Ser Gly Gly Gly Gly 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  12

Gly Ser Gly Gly Gly 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  13

Gly Gly Ser Gly Gly 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  14

Gly Gly Gly Ser Gly 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  15

Gly Gly Gly Gly Ser 
1               5   


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  16

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  17

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  18

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  19

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210>  20
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  20

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  21
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  21

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser 
            20      


<210>  22
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  22

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser 
            20                  


<210>  23
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  23

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            20                  25          


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  24

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  25

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  26

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  27

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  28
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  28

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  


<210>  29
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  29

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25              


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  30

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  31

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  32

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  33
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  33

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  34

Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser 
1               5                   10  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  35

Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser 
1               5                   10                  15  


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  36

Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210>  37
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  37

Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Ser Gly Gly Ser Gly Ser 
            20                  25  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  38

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  39

Gly Gly Ser Gly Gly Gly Ser Ser Gly Gly 
1               5                   10  


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  40

Gly Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Ile Arg 
            20                  25                  


<210>  41
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  41

Gly Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Glu Phe Leu Ala 
            20                  25                  30  


<210>  42
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  42

Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp 
1               5                   10                  15      


Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg 
            20                  25                  30          


Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser 
        35                  40                  45              


Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu 
    50                  55                  60                  


Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn 
65                  70                  75                  80  


Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly 
                85                  90                  95      


Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe 
            100                 105                 110         


Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp 
        115                 120                 125             


Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala 
    130                 135                 140                 


Leu 
145 


<210>  43
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  43

Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
1               5                   10                  15      


Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala 
            20                  25                  30          


Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro 
        35                  40                  45              


Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln 
    50                  55                  60                  


Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile 
65                  70                  75                  80  


Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser 
                85                  90                  95      


Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
            100                 105                 110         


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
        115                 120                 125             


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser 
    130                 135                 140                 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 


<210>  44
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
1               5                   10                  15      


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
            20                  25                  30          


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
        35                  40                  45              


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
    50                  55                  60                  


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
65                  70                  75                  80  


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
                85                  90                  95      


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
            100                 105                 110         


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
        115                 120                 125             


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
    130                 135                 140                 


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
145                 150                 155                 160 


Val Gly 
        


<210>  45
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
1               5                   10                  15      


Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
            20                  25                  30          


Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
        35                  40                  45              


Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
    50                  55                  60                  


Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
65                  70                  75                  80  


Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
                85                  90                  95      


Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
            100                 105                 110         


Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
        115                 120                 125             


Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
    130                 135                 140                 


Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
145                 150                 155                 160 


Phe Leu Val Gly 
                


<210>  46
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 
1               5                   10                  15      


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
            20                  25                  30          


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
        35                  40                  45              


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
    50                  55                  60                  


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
65                  70                  75                  80  


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
                85                  90                  95      


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
            100                 105                 110         


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
        115                 120                 125             


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
    130                 135                 140                 


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
145                 150                 155                 160 


Gly Ala Phe Leu Val Gly 
                165     


<210>  47
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  47

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly 
                165             


<210>  48
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  48

Thr Ser Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile 
1               5                   10                  15      


Ser Pro Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        35                  40                  45              


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            100                 105                 110         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        115                 120                 125             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    130                 135                 140                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
145                 150                 155                 160 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                165                 170                 175     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            180                 185         


<210>  49
<211>  193
<212>  PRT
<213>  Mus musculus

<400>  49

Thr Phe Gln Asp Thr Ile Ser Thr Val Pro Glu Lys Gln Leu Ser Thr 
1               5                   10                  15      


Pro Pro Leu Pro Arg Gly Gly Arg Pro Gln Lys Val Ala Ala His Ile 
            20                  25                  30          


Thr Gly Ile Thr Arg Arg Ser Asn Ser Ala Leu Ile Pro Ile Ser Lys 
        35                  40                  45              


Asp Gly Lys Thr Leu Gly Gln Lys Ile Glu Ser Trp Glu Ser Ser Arg 
    50                  55                  60                  


Lys Gly His Ser Phe Leu Asn His Val Leu Phe Arg Asn Gly Glu Leu 
65                  70                  75                  80  


Val Ile Glu Gln Glu Gly Leu Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                85                  90                  95      


Arg Phe Gln Glu Ala Glu Asp Ala Ser Lys Met Val Ser Lys Asp Lys 
            100                 105                 110         


Val Arg Thr Lys Gln Leu Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Val Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Arg Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Leu Phe 
145                 150                 155                 160 


Glu Leu Lys Lys Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Met Asp Leu Asp Gln Glu Ala Ser Phe Phe Gly Ala Phe Leu Ile 
            180                 185                 190         


Asn 
    


<210>  50
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  50

Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro 
1               5                   10                  15      


Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys 
            20                  25                  30          


Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val 
        35                  40                  45              


Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu 
    50                  55                  60                  


Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val 
65                  70                  75                  80  


Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp 
                85                  90                  95      


Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp 
            100                 105                 110         


His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu 
        115                 120                 125             


Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
    130                 135             


<210>  51
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  51

Glu Leu Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser 
1               5                   10                  15      


Met Pro Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly 
            20                  25                  30          


Val Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr 
        35                  40                  45              


Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu 
    50                  55                  60                  


Pro Leu Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp 
65                  70                  75                  80  


Leu Val Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln 
                85                  90                  95      


Met Trp Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser 
            100                 105                 110         


Ala Asp His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe 
        115                 120                 125             


Glu Glu Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
    130                 135                 140 


<210>  52
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  52

Pro Pro Glu Lys Lys Glu Leu Arg Lys Val Ala His Leu Thr Gly Lys 
1               5                   10                  15      


Ser Asn Ser Arg Ser Met Pro Leu Glu Trp Glu Asp Thr Tyr Gly Ile 
            20                  25                  30          


Val Leu Leu Ser Gly Val Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn 
        35                  40                  45              


Glu Thr Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln 
    50                  55                  60                  


Ser Cys Asn Asn Leu Pro Leu Ser His Lys Val Tyr Met Arg Asn Ser 
65                  70                  75                  80  


Lys Tyr Pro Gln Asp Leu Val Met Met Glu Gly Lys Met Met Ser Tyr 
                85                  90                  95      


Cys Thr Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr Leu Gly Ala Val 
            100                 105                 110         


Phe Asn Leu Thr Ser Ala Asp His Leu Tyr Val Asn Val Ser Glu Leu 
        115                 120                 125             


Ser Leu Val Asn Phe Glu Glu Ser Gln Thr Phe Phe Gly Leu Tyr Lys 
    130                 135                 140                 


Leu 
145 


<210>  53
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  53

Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg Lys 
1               5                   10                  15      


Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu Glu 
            20                  25                  30          


Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr Lys 
        35                  40                  45              


Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr Ser 
    50                  55                  60                  


Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser His 
65                  70                  75                  80  


Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met Met 
                85                  90                  95      


Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala Arg 
            100                 105                 110         


Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His Leu 
        115                 120                 125             


Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser Gln 
    130                 135                 140                 


Thr Phe Phe Gly Leu Tyr Lys Leu 
145                 150         


<210>  54
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Met His Thr Ala Ser Ser Leu Glu Lys Gln Ile Gly His Pro Ser 
1               5                   10                  15      


Pro Pro Pro Glu Lys Lys Glu Leu Arg Lys Val Ala His Leu Thr Gly 
            20                  25                  30          


Lys Ser Asn Ser Arg Ser Met Pro Leu Glu Trp Glu Asp Thr Tyr Gly 
        35                  40                  45              


Ile Val Leu Leu Ser Gly Val Lys Tyr Lys Lys Gly Gly Leu Val Ile 
    50                  55                  60                  


Asn Glu Thr Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly 
65                  70                  75                  80  


Gln Ser Cys Asn Asn Leu Pro Leu Ser His Lys Val Tyr Met Arg Asn 
                85                  90                  95      


Ser Lys Tyr Pro Gln Asp Leu Val Met Met Glu Gly Lys Met Met Ser 
            100                 105                 110         


Tyr Cys Thr Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr Leu Gly Ala 
        115                 120                 125             


Val Phe Asn Leu Thr Ser Ala Asp His Leu Tyr Val Asn Val Ser Glu 
    130                 135                 140                 


Leu Ser Leu Val Asn Phe Glu Glu Ser Gln Thr Phe Phe Gly Leu Tyr 
145                 150                 155                 160 


Lys Leu 
        


<210>  55
<211>  143
<212>  PRT
<213>  Mus musculus

<400>  55

Glu Lys Lys Glu Pro Arg Ser Val Ala His Leu Thr Gly Asn Pro His 
1               5                   10                  15      


Ser Arg Ser Ile Pro Leu Glu Trp Glu Asp Thr Tyr Gly Thr Ala Leu 
            20                  25                  30          


Ile Ser Gly Val Lys Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr 
        35                  40                  45              


Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys 
    50                  55                  60                  


Asn Asn Gln Pro Leu Asn His Lys Val Tyr Met Arg Asn Ser Lys Tyr 
65                  70                  75                  80  


Pro Glu Asp Leu Val Leu Met Glu Glu Lys Arg Leu Asn Tyr Cys Thr 
                85                  90                  95      


Thr Gly Gln Ile Trp Ala His Ser Ser Tyr Leu Gly Ala Val Phe Asn 
            100                 105                 110         


Leu Thr Ser Ala Asp His Leu Tyr Val Asn Ile Ser Gln Leu Ser Leu 
        115                 120                 125             


Ile Asn Phe Glu Glu Ser Lys Thr Phe Phe Gly Leu Tyr Lys Leu 
    130                 135                 140             


<210>  56
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  56

Ser Asn Leu Lys Pro Ala Ala His Leu Ile Gly Asp Pro Ser Lys Gln 
1               5                   10                  15      


Asn Ser Leu Leu Trp Arg Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp 
            20                  25                  30          


Gly Phe Ser Leu Ser Asn Asn Ser Leu Leu Val Pro Thr Ser Gly Ile 
        35                  40                  45              


Tyr Phe Val Tyr Ser Gln Val Val Phe Ser Gly Lys Ala Tyr Ser Pro 
    50                  55                  60                  


Lys Ala Thr Ser Ser Pro Leu Tyr Leu Ala His Glu Val Gln Leu Phe 
65                  70                  75                  80  


Ser Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser Ser Gln Lys Met 
                85                  90                  95      


Val Tyr Pro Gly Leu Gln Glu Pro Trp Leu His Ser Met Tyr His Gly 
            100                 105                 110         


Ala Ala Phe Gln Leu Thr Gln Gly Asp Gln Leu Ser Thr His Thr Asp 
        115                 120                 125             


Gly Ile Pro His Leu Val Leu Ser Pro Ser Thr Val Phe Phe Gly Ala 
    130                 135                 140                 


Phe Ala Leu 
145         


<210>  57
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  57

Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro Leu 
1               5                   10                  15      


Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe Leu 
            20                  25                  30          


Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro Gln 
        35                  40                  45              


Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg Ala 
    50                  55                  60                  


Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg Ser 
65                  70                  75                  80  


Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu Leu 
                85                  90                  95      


Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala Arg 
            100                 105                 110         


Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly 
        115                 120                 125             


Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser His 
    130                 135                 140                 


Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala Val 
145                 150                 155                 160 


Met Val Gly 
            


<210>  58
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  58

Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro Leu Lys Gly Gln Gly 
1               5                   10                  15      


Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe Leu Thr Ser Gly Thr 
            20                  25                  30          


Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro Gln Asp Gly Leu Tyr 
        35                  40                  45              


Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg Ala Pro Pro Gly Gly 
    50                  55                  60                  


Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg Ser Ser Leu Tyr Arg 
65                  70                  75                  80  


Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu Leu Leu Leu Glu Gly 
                85                  90                  95      


Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala Arg Arg Gln Gly Tyr 
            100                 105                 110         


Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Val Gln Leu 
        115                 120                 125             


Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val 
    130                 135                 140                 


Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly 
145                 150                 155                 


<210>  59
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  59

Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
1               5                   10                  15      


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
            20                  25                  30          


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
        35                  40                  45              


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
    50                  55                  60                  


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
65                  70                  75                  80  


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
                85                  90                  95      


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
            100                 105                 110         


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
        115                 120                 125             


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
    130                 135             


<210>  60
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  60

Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys Leu Ser Trp Asn Lys 
1               5                   10                  15      


Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp Gly Asn Leu Val Ile 
            20                  25                  30          


Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln Leu Gln Phe Leu Val 
        35                  40                  45              


Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu Glu Leu Leu Ile Asn 
    50                  55                  60                  


Lys His Ile Lys Lys Gln Ala Leu Val Thr Val Cys Glu Ser Gly Met 
65                  70                  75                  80  


Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln Phe Leu Leu Asp Tyr 
                85                  90                  95      


Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val Asp Thr Phe Gln Tyr 
            100                 105                 110         


Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val Leu Ser Ile Phe Leu 
        115                 120                 125             


Tyr Ser Asn Ser Asp 
    130             


<210>  61
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser 
1               5                   10                  15      


Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr 
            20                  25                  30          


Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val 
        35                  40                  45              


Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser 
    50                  55                  60                  


Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu 
65                  70                  75                  80  


Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr 
                85                  90                  95      


His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly 
            100                 105                 110         


Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp 
        115                 120                 125             


Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu 
    130                 135                 140                 


Lys Leu 
145     


<210>  62
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
1               5                   10                  15      


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
        35                  40                  45              


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
    50                  55                  60                  


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
65                  70                  75                  80  


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
                85                  90                  95      


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
            100                 105                 110         


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
        115                 120                 125             


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
    130                 135                 140                 


Gly Leu Leu Lys Leu 
145                 


<210>  63
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  63

Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr 
1               5                   10                  15      


Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
            20                  25                  30          


Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly 
        35                  40                  45              


Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile 
    50                  55                  60                  


Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
65                  70                  75                  80  


Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                85                  90                  95      


Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe 
            100                 105                 110         


His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu 
        115                 120                 125             


Phe Cys Val Leu 
    130         


<210>  64
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  64

Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys 
1               5                   10                  15      


Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met 
            20                  25                  30          


Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu 
        35                  40                  45              


Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His 
    50                  55                  60                  


Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser 
65                  70                  75                  80  


Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr 
                85                  90                  95      


Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn 
            100                 105                 110         


Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val 
        115                 120                 125             


Leu 
    


<210>  65
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile Pro 
1               5                   10                  15      


Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His Asp Arg Gly 
            20                  25                  30          


Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Ile Val 
        35                  40                  45              


Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His 
    50                  55                  60                  


His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 
65                  70                  75                  80  


Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 
                85                  90                  95      


Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 
            100                 105                 110         


Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 
        115                 120                 125             


Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp 
    130                 135                 140                 


Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp 
145                 150                 155         


<210>  66
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  66

Ile Arg Ala Glu Lys Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala 
1               5                   10                  15      


Lys Arg Ser Lys Leu Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn 
            20                  25                  30          


Ala Thr Asp Ile Pro Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp 
        35                  40                  45              


Tyr His Asp Arg Gly Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn 
    50                  55                  60                  


Gly Lys Leu Ile Val Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn 
65                  70                  75                  80  


Ile Cys Phe Arg His His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr 
                85                  90                  95      


Leu Gln Leu Met Val Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser 
            100                 105                 110         


Ser His Thr Leu Met Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn 
        115                 120                 125             


Ser Glu Phe His Phe Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu 
    130                 135                 140                 


Arg Ser Gly Glu Glu Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu 
145                 150                 155                 160 


Asp Pro Asp Gln Asp Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp 
                165                 170                 175     


Ile Asp 
        


<210>  67
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  67

Ser Ala Pro Lys Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala 
1               5                   10                  15      


His Tyr Glu Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly 
            20                  25                  30          


Val Asp Gly Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser 
        35                  40                  45              


Ser Pro Leu Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg 
    50                  55                  60                  


Ala Gly Leu Tyr Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys 
65                  70                  75                  80  


Ala Val Tyr Leu Lys Leu Asp Leu Leu Val Asp Gly Val Leu Ala Leu 
                85                  90                  95      


Arg Cys Leu Glu Glu Phe Ser Ala Thr Ala Ala Ser Ser Leu Gly Pro 
            100                 105                 110         


Gln Leu Arg Leu Cys Gln Val Ser Gly Leu Leu Ala Leu Arg Pro Gly 
        115                 120                 125             


Ser Ser Leu Arg Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala 
    130                 135                 140                 


Pro Phe Leu Thr Tyr Phe Gly Leu Phe Gln Val His 
145                 150                 155     


<210>  68
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  68

Arg Ala Ile Ala Ala His Tyr Glu Val His Pro Arg Pro Gly Gln Asp 
1               5                   10                  15      


Gly Ala Gln Ala Gly Val Asp Gly Thr Val Ser Gly Trp Glu Glu Ala 
            20                  25                  30          


Arg Ile Asn Ser Ser Ser Pro Leu Arg Tyr Asn Arg Gln Ile Gly Glu 
        35                  40                  45              


Phe Ile Val Thr Arg Ala Gly Leu Tyr Tyr Leu Tyr Cys Gln Val His 
    50                  55                  60                  


Phe Asp Glu Gly Lys Ala Val Tyr Leu Lys Leu Asp Leu Leu Val Asp 
65                  70                  75                  80  


Gly Val Leu Ala Leu Arg Cys Leu Glu Glu Phe Ser Ala Thr Ala Ala 
                85                  90                  95      


Ser Ser Leu Gly Pro Gln Leu Arg Leu Cys Gln Val Ser Gly Leu Leu 
            100                 105                 110         


Ala Leu Arg Pro Gly Ser Ser Leu Arg Ile Arg Thr Leu Pro Trp Ala 
        115                 120                 125             


His Leu Lys Ala Ala Pro Phe Leu Thr Tyr Phe Gly Leu Phe Gln Val 
    130                 135                 140                 


His 
145 


<210>  69
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  69

Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala His Leu 
1               5                   10                  15      


Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp 
            20                  25                  30          


Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr His Asp 
        35                  40                  45              


Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys 
    50                  55                  60                  


Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile 
65                  70                  75                  80  


Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu 
                85                  90                  95      


Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser 
            100                 105                 110         


Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu 
        115                 120                 125             


Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu Val Arg 
    130                 135                 140                 


Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
145                 150                 155             


<210>  70
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  70

Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly 
1               5                   10                  15      


Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly 
            20                  25                  30          


Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile 
        35                  40                  45              


His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile 
    50                  55                  60                  


Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val 
65                  70                  75                  80  


Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser 
                85                  90                  95      


Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala 
            100                 105                 110         


Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser 
        115                 120                 125             


Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
    130                 135                 140             


<210>  71
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  71

Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro 
1               5                   10                  15      


Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His 
            20                  25                  30          


Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile 
        35                  40                  45              


Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr Thr 
    50                  55                  60                  


Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser Pro 
65                  70                  75                  80  


Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly Cys 
                85                  90                  95      


Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr Leu 
            100                 105                 110         


Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu 
        115                 120                 125             


Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
    130                 135             


<210>  72
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  72

Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
1               5                   10                  15      


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            20                  25                  30          


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        35                  40                  45              


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    50                  55                  60                  


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
65                  70                  75                  80  


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                85                  90                  95      


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            100                 105                 110         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        115                 120                 125             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    130                 135                 140                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
145                 150                 155                 160 


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170 


<210>  73
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  73

Gln Leu Glu Thr Ala Lys Glu Pro Cys Met Ala Lys Phe Gly Pro Leu 
1               5                   10                  15      


Pro Ser Lys Trp Gln Met Ala Ser Ser Glu Pro Pro Cys Val Asn Lys 
            20                  25                  30          


Val Ser Asp Trp Lys Leu Glu Ile Leu Gln Asn Gly Leu Tyr Leu Ile 
        35                  40                  45              


Tyr Gly Gln Val Ala Pro Asn Ala Asn Tyr Asn Asp Val Ala Pro Phe 
    50                  55                  60                  


Glu Val Arg Leu Tyr Lys Asn Lys Asp Met Ile Gln Thr Leu Thr Asn 
65                  70                  75                  80  


Lys Ser Lys Ile Gln Asn Val Gly Gly Thr Tyr Glu Leu His Val Gly 
                85                  90                  95      


Asp Thr Ile Asp Leu Ile Phe Asn Ser Glu His Gln Val Leu Lys Asn 
            100                 105                 110         


Asn Thr Tyr Trp Gly Ile Ile Leu Leu Ala Asn Pro Gln Phe Ile Ser 
        115                 120                 125             


<210>  74
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  74

Lys Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser 
1               5                   10                  15      


Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg 
            20                  25                  30          


Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp 
        35                  40                  45              


Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr 
    50                  55                  60                  


Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu 
65                  70                  75                  80  


Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala 
                85                  90                  95      


Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp 
            100                 105                 110         


Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser 
        115                 120                 125             


Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu 
    130                 135                 


<210>  75
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  75

Glu Asn Gln Pro Ala Val Val His Leu Gln Gly Gln Gly Ser Ala Ile 
1               5                   10                  15      


Gln Val Lys Asn Asp Leu Ser Gly Gly Val Leu Asn Asp Trp Ser Arg 
            20                  25                  30          


Ile Thr Met Asn Pro Lys Val Phe Lys Leu His Pro Arg Ser Gly Glu 
        35                  40                  45              


Leu Glu Val Leu Val Asp Gly Thr Tyr Phe Ile Tyr Ser Gln Val Glu 
    50                  55                  60                  


Val Tyr Tyr Ile Asn Phe Thr Asp Phe Ala Ser Tyr Glu Val Val Val 
65                  70                  75                  80  


Asp Glu Lys Pro Phe Leu Gln Cys Thr Arg Ser Ile Glu Thr Gly Lys 
                85                  90                  95      


Thr Asn Tyr Asn Thr Cys Tyr Thr Ala Gly Val Cys Leu Leu Lys Ala 
            100                 105                 110         


Arg Gln Lys Ile Ala Val Lys Met Val His Ala Asp Ile Ser Ile Asn 
        115                 120                 125             


Met Ser Lys His Thr Thr Phe Phe Gly Ala Ile Arg Leu Gly Glu Ala 
    130                 135                 140                 


Pro Ala Ser 
145         


<210>  76
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  76

Glu Asn Gln Pro Ala Val Val His Leu Gln Gly Gln Gly Ser Ala Ile 
1               5                   10                  15      


Gln Val Lys Asn Asp Leu Ser Gly Gly Val Leu Asn Asp Trp Ser Arg 
            20                  25                  30          


Ile Thr Met Asn Pro Lys Val Phe Lys Leu His Pro Arg Ser Gly Glu 
        35                  40                  45              


Leu Glu Val Leu Val Asp Gly Thr Tyr Phe Ile Tyr Ser Gln Val Tyr 
    50                  55                  60                  


Tyr Ile Asn Phe Thr Asp Phe Ala Ser Tyr Glu Val Val Val Asp Glu 
65                  70                  75                  80  


Lys Pro Phe Leu Gln Cys Thr Arg Ser Ile Glu Thr Gly Lys Thr Asn 
                85                  90                  95      


Tyr Asn Thr Cys Tyr Thr Ala Gly Val Cys Leu Leu Lys Ala Arg Gln 
            100                 105                 110         


Lys Ile Ala Val Lys Met Val His Ala Asp Ile Ser Ile Asn Met Ser 
        115                 120                 125             


Lys His Thr Thr Phe Phe Gly Ala Ile Arg Leu Gly Glu Ala Pro Ala 
    130                 135                 140                 


Ser 
145 


<210>  77
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  77

Leu Lys Gly Gln Glu Phe Ala Pro Ser His Gln Gln Val Tyr Ala Pro 
1               5                   10                  15      


Leu Arg Ala Asp Gly Asp Lys Pro Arg Ala His Leu Thr Val Val Arg 
            20                  25                  30          


Gln Thr Pro Thr Gln His Phe Lys Asn Gln Phe Pro Ala Leu His Trp 
        35                  40                  45              


Glu His Glu Leu Gly Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr 
    50                  55                  60                  


Asn Lys Phe Leu Leu Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser 
65                  70                  75                  80  


Gln Val Thr Phe Arg Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln 
                85                  90                  95      


Ala Gly Arg Pro Asn Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys 
            100                 105                 110         


Val Thr Asp Ser Tyr Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys 
        115                 120                 125             


Ser Val Cys Glu Val Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly 
    130                 135                 140                 


Ala Met Phe Ser Leu Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser 
145                 150                 155                 160 


Asp Ile Ser Leu Val Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly 
                165                 170                 175     


Ala Phe Leu Leu 
            180 


<210>  78
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  78

Asp Lys Pro Arg Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln 
1               5                   10                  15      


His Phe Lys Asn Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly 
            20                  25                  30          


Leu Ala Phe Thr Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu 
        35                  40                  45              


Ile Pro Glu Ser Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg 
    50                  55                  60                  


Gly Met Thr Ser Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn 
65                  70                  75                  80  


Lys Pro Asp Ser Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr 
                85                  90                  95      


Pro Glu Pro Thr Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val 
            100                 105                 110         


Gly Ser Asn Trp Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu 
        115                 120                 125             


Gln Glu Gly Asp Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val 
    130                 135                 140                 


Asp Tyr Thr Lys Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
145                 150                 155                 


<210>  79
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu 
1               5                   10                  15      


Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe 
            20                  25                  30          


Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys 
        35                  40                  45              


Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly 
    50                  55                  60                  


Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln 
65                  70                  75                  80  


Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu 
                85                  90                  95      


Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys 
            100                 105                 110         


Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu 
        115                 120                 125             


Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr 
    130                 135                 140                 


Phe Phe Gly Ala Leu Lys Leu Leu 
145                 150         


<210>  80
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  80

Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
1               5                   10                  15      


Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala 
            20                  25                  30          


Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro 
        35                  40                  45              


Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln 
    50                  55                  60                  


Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile 
65                  70                  75                  80  


Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser 
                85                  90                  95      


Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
            100                 105                 110         


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
        115                 120                 125             


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser 
    130                 135                 140                 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 


<210>  81
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTNFR2

<400>  81

Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
1               5                   10                  15      


Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala 
            20                  25                  30          


Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro 
        35                  40                  45              


Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln 
    50                  55                  60                  


Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile 
65                  70                  75                  80  


Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser 
                85                  90                  95      


Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
            100                 105                 110         


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
        115                 120                 125             


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser 
    130                 135                 140                 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser 
145                 150                 155                 160 


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                165                 170                 175     


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            180                 185                 190         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        195                 200                 205             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    210                 215                 220                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
225                 230                 235                 240 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                245                 250                 255     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            260                 265                 270         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        275                 280                 285             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly 
    290                 295                 300                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser 
305                 310                 315                 320 


Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
                325                 330                 335     


Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
            340                 345                 350         


Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
        355                 360                 365             


Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
    370                 375                 380                 


Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
385                 390                 395                 400 


Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
                405                 410                 415     


Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
            420                 425                 430         


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
        435                 440                 445             


Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly Gln 
    450                 455                 460                 


Val Tyr Phe Gly Ile Ile Ala Leu 
465                 470         


<210>  82
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  82

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  83
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  83

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
1               5                   10                  15      


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            20                  25                  30          


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        35                  40                  45              


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    50                  55                  60                  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
65                  70                  75                  80  


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                85                  90                  95      


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            100                 105                 110         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        115                 120                 125             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    130                 135                 140                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
145                 150                 155                 160 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                165                 170                 175     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            180                 185                 190         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        195                 200                 205             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    210                 215                 220                 


Gly Gly 
225     


<210>  84
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  84

Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
1               5                   10                  15      


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
            20                  25                  30          


Asp Ala Gln Ala Gly Lys Glu Pro 
        35                  40  


<210>  85
<211>  33
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  85

Arg Leu Lys Gln Ile Glu Asp Lys Leu Glu Glu Ile Leu Ser Lys Leu 
1               5                   10                  15      


Tyr His Ile Glu Asn Glu Leu Ala Arg Ile Lys Lys Leu Leu Gly Glu 
            20                  25                  30          


Arg 
    


<210>  86
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  86

Pro Ser Ser Ser Asp Tyr Ser Asp Leu Gln Arg Val Lys Gln Glu Leu 
1               5                   10                  15      


Leu Glu Glu Val Lys Lys Glu Leu Gln Lys Val Lys Glu Glu Ile Ile 
            20                  25                  30          


Glu Ala Phe Val Gln Glu Leu Arg Lys Arg Gly Ser Pro 
        35                  40                  45  


<210>  87
<211>  1190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTNFR2-Fc-scTNFR2

<400>  87

Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
1               5                   10                  15      


Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala 
            20                  25                  30          


Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro 
        35                  40                  45              


Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln 
    50                  55                  60                  


Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile 
65                  70                  75                  80  


Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser 
                85                  90                  95      


Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr 
            100                 105                 110         


Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg 
        115                 120                 125             


Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser 
    130                 135                 140                 


Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser 
145                 150                 155                 160 


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                165                 170                 175     


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            180                 185                 190         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        195                 200                 205             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    210                 215                 220                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
225                 230                 235                 240 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                245                 250                 255     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            260                 265                 270         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        275                 280                 285             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly 
    290                 295                 300                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser 
305                 310                 315                 320 


Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
                325                 330                 335     


Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
            340                 345                 350         


Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
        355                 360                 365             


Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
    370                 375                 380                 


Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
385                 390                 395                 400 


Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
                405                 410                 415     


Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
            420                 425                 430         


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
        435                 440                 445             


Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly Gln 
    450                 455                 460                 


Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
                485                 490                 495     


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            500                 505                 510         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        515                 520                 525             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    530                 535                 540                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
545                 550                 555                 560 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                565                 570                 575     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            580                 585                 590         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        595                 600                 605             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    610                 615                 620                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
625                 630                 635                 640 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                645                 650                 655     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            660                 665                 670         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        675                 680                 685             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    690                 695                 700                 


Ser Pro Gly Gly Gly Gly Ser Gly Gly Gly Ser Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
                725                 730                 735     


Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
            740                 745                 750         


Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
        755                 760                 765             


Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
    770                 775                 780                 


Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
785                 790                 795                 800 


Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
                805                 810                 815     


Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
            820                 825                 830         


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
        835                 840                 845             


Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly Gln 
    850                 855                 860                 


Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser Arg 
865                 870                 875                 880 


Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala 
                885                 890                 895     


Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala 
            900                 905                 910         


Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly 
        915                 920                 925             


Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro 
    930                 935                 940                 


Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser 
945                 950                 955                 960 


Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln 
                965                 970                 975     


Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile 
            980                 985                 990         


Tyr Leu Gly Gly Val Phe Gln Leu  Glu Lys Gly Asp Arg  Leu Ser Ala 
        995                 1000                 1005             


Glu Ile  Asn Arg Pro Asp Tyr  Leu Asn Phe Arg Glu  Ser Gly Gln 
    1010                 1015                 1020             


Val Tyr  Phe Gly Ile Ile Ala  Leu Gly Gly Gly Gly  Ser Ser Ser 
    1025                 1030                 1035             


Arg Thr  Pro Ser Asp Lys Pro  Val Ala His Val Val  Ala Asn Pro 
    1040                 1045                 1050             


Gln Ala  Glu Gly Gln Leu Gln  Trp Leu Asn Arg Arg  Ala Asn Ala 
    1055                 1060                 1065             


Leu Leu  Ala Asn Gly Val Glu  Leu Arg Asp Asn Gln  Leu Val Val 
    1070                 1075                 1080             


Pro Ser  Glu Gly Leu Tyr Leu  Ile Tyr Ser Gln Val  Leu Phe Lys 
    1085                 1090                 1095             


Gly Gln  Gly Cys Pro Ser Thr  His Val Leu Leu Thr  His Thr Ile 
    1100                 1105                 1110             


Ser Arg  Ile Ala Val Ser Tyr  Gln Thr Lys Val Asn  Leu Leu Ser 
    1115                 1120                 1125             


Ala Ile  Lys Ser Pro Cys Gln  Arg Glu Thr Pro Glu  Gly Ala Glu 
    1130                 1135                 1140             


Ala Lys  Pro Trp Tyr Glu Pro  Ile Tyr Leu Gly Gly  Val Phe Gln 
    1145                 1150                 1155             


Leu Glu  Lys Gly Asp Arg Leu  Ser Ala Glu Ile Asn  Arg Pro Asp 
    1160                 1165                 1170             


Tyr Leu  Asn Phe Arg Glu Ser  Gly Gln Val Tyr Phe  Gly Ile Ile 
    1175                 1180                 1185             


Ala Leu  
    1190 


<210>  88
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p53-scTNFR2

<400>  88

Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
1               5                   10                  15      


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
            20                  25                  30          


Asp Ala Gln Ala Gly Lys Glu Pro Gly Ala Pro Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Glu Phe Leu Ala Ser Ser Arg Thr Pro Ser Asp Lys Pro Val 
65                  70                  75                  80  


Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu 
                85                  90                  95      


Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp 
            100                 105                 110         


Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln 
        115                 120                 125             


Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr 
    130                 135                 140                 


His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu 
145                 150                 155                 160 


Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala 
                165                 170                 175     


Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln 
            180                 185                 190         


Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr 
        195                 200                 205             


Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
    210                 215                 220                 


Gly Gly Gly Gly Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala 
225                 230                 235                 240 


His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn 
                245                 250                 255     


Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn 
            260                 265                 270         


Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val 
        275                 280                 285             


Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His 
    290                 295                 300                 


Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu 
305                 310                 315                 320 


Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu 
                325                 330                 335     


Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu 
            340                 345                 350         


Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu 
        355                 360                 365             


Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly 
    370                 375                 380                 


Gly Gly Gly Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
385                 390                 395                 400 


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
                405                 410                 415     


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
            420                 425                 430         


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
        435                 440                 445             


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
    450                 455                 460                 


Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser 
465                 470                 475                 480 


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala 
                485                 490                 495     


Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu 
            500                 505                 510         


Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn 
        515                 520                 525             


Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
    530                 535                 540         


<210>  89
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4-sc-TNFR2

<400>  89

Arg Leu Lys Gln Ile Glu Asp Lys Leu Glu Glu Ile Leu Ser Lys Leu 
1               5                   10                  15      


Tyr His Ile Glu Asn Glu Leu Ala Arg Ile Lys Lys Leu Leu Gly Glu 
            20                  25                  30          


Arg Gly Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Glu Phe Leu Ala Ser 
    50                  55                  60                  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
65                  70                  75                  80  


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
                85                  90                  95      


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
            100                 105                 110         


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
        115                 120                 125             


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
    130                 135                 140                 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
145                 150                 155                 160 


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
                165                 170                 175     


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
            180                 185                 190         


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly 
        195                 200                 205             


Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser 
    210                 215                 220                 


Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
225                 230                 235                 240 


Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
                245                 250                 255     


Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
            260                 265                 270         


Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
        275                 280                 285             


Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
    290                 295                 300                 


Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
305                 310                 315                 320 


Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
                325                 330                 335     


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
            340                 345                 350         


Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly Gln 
        355                 360                 365             


Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser Arg 
    370                 375                 380                 


Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala 
385                 390                 395                 400 


Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala 
                405                 410                 415     


Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly 
            420                 425                 430         


Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro 
        435                 440                 445             


Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser 
    450                 455                 460                 


Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln 
465                 470                 475                 480 


Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile 
                485                 490                 495     


Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala 
            500                 505                 510         


Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val 
        515                 520                 525             


Tyr Phe Gly Ile Ile Ala Leu 
    530                 535 


<210>  90
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VASP-scTNFR2

<400>  90

Pro Ser Ser Ser Asp Tyr Ser Asp Leu Gln Arg Val Lys Gln Glu Leu 
1               5                   10                  15      


Leu Glu Glu Val Lys Lys Glu Leu Gln Lys Val Lys Glu Glu Ile Ile 
            20                  25                  30          


Glu Ala Phe Val Gln Glu Leu Arg Lys Arg Gly Ser Pro Gly Ala Pro 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Ser Glu Phe Leu Ala Ser Ser Arg Thr Pro 
65                  70                  75                  80  


Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly 
                85                  90                  95      


Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly 
            100                 105                 110         


Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr 
        115                 120                 125             


Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr 
    130                 135                 140                 


His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln 
145                 150                 155                 160 


Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu 
                165                 170                 175     


Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu 
            180                 185                 190         


Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile 
        195                 200                 205             


Asn Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe 
    210                 215                 220                 


Gly Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser Arg Thr Pro Ser 
225                 230                 235                 240 


Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln 
                245                 250                 255     


Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val 
            260                 265                 270         


Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu 
        275                 280                 285             


Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His 
    290                 295                 300                 


Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr 
305                 310                 315                 320 


Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr 
                325                 330                 335     


Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly 
            340                 345                 350         


Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn 
        355                 360                 365             


Arg Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly 
    370                 375                 380                 


Ile Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser Arg Thr Pro Ser Asp 
385                 390                 395                 400 


Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu 
                405                 410                 415     


Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu 
            420                 425                 430         


Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile 
        435                 440                 445             


Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val 
    450                 455                 460                 


Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys 
465                 470                 475                 480 


Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro 
                485                 490                 495     


Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly 
            500                 505                 510         


Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg 
        515                 520                 525             


Pro Asp Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Ile 
    530                 535                 540                 


Ile Ala Leu 
545         


<210>  91
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p53-sc-mTNFR2

<400>  91

Lys Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg 
1               5                   10                  15      


Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys 
            20                  25                  30          


Asp Ala Gln Ala Gly Lys Glu Pro Gly Ala Pro Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Gly Ile Arg Ser Asp Lys Pro Val Ala His Val Val Ala Asn 
65                  70                  75                  80  


His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala 
                85                  90                  95      


Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val Val Pro 
            100                 105                 110         


Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys Gly Gln 
        115                 120                 125             


Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg Phe Ala 
    130                 135                 140                 


Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys Ser Pro 
145                 150                 155                 160 


Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu 
                165                 170                 175     


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Gln Leu 
            180                 185                 190         


Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly 
        195                 200                 205             


Gln Val Tyr Phe Gly Val Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser 
    210                 215                 220                 


Asp Lys Pro Val Ala His Val Val Ala Asn His Gln Val Glu Glu Gln 
225                 230                 235                 240 


Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly Met 
                245                 250                 255     


Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu 
            260                 265                 270         


Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val 
        275                 280                 285             


Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys 
    290                 295                 300                 


Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys Pro Lys Asp Thr Pro 
305                 310                 315                 320 


Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly 
                325                 330                 335     


Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu Val Asn Leu 
            340                 345                 350         


Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Val 
        355                 360                 365             


Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser Asp Lys Pro Val Ala His 
    370                 375                 380                 


Val Val Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln 
385                 390                 395                 400 


Arg Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln 
                405                 410                 415     


Leu Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu 
            420                 425                 430         


Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val 
        435                 440                 445             


Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala 
    450                 455                 460                 


Val Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys 
465                 470                 475                 480 


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
                485                 490                 495     


Gly Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe 
            500                 505                 510         


Arg Glu Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
        515                 520                 525 


<210>  92
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4-sc-mTNFR2

<400>  92

Arg Leu Lys Gln Ile Glu Asp Lys Leu Glu Glu Ile Leu Ser Lys Leu 
1               5                   10                  15      


Tyr His Ile Glu Asn Glu Leu Ala Arg Ile Lys Lys Leu Leu Gly Glu 
            20                  25                  30          


Arg Gly Ala Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Ile Arg Ser Asp 
    50                  55                  60                  


Lys Pro Val Ala His Val Val Ala Asn His Gln Val Glu Glu Gln Leu 
65                  70                  75                  80  


Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly Met Asp 
                85                  90                  95      


Leu Lys Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu Val 
            100                 105                 110         


Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu 
        115                 120                 125             


Leu Thr His Thr Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val 
    130                 135                 140                 


Asn Leu Leu Ser Ala Val Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu 
145                 150                 155                 160 


Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val 
                165                 170                 175     


Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu Val Asn Leu Pro 
            180                 185                 190         


Lys Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Val Ile 
        195                 200                 205             


Ala Leu Gly Gly Gly Gly Ser Ser Ser Asp Lys Pro Val Ala His Val 
    210                 215                 220                 


Val Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg 
225                 230                 235                 240 


Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu 
                245                 250                 255     


Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe 
            260                 265                 270         


Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser 
        275                 280                 285             


Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val 
    290                 295                 300                 


Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro 
305                 310                 315                 320 


Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly 
                325                 330                 335     


Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg 
            340                 345                 350         


Glu Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu Gly Gly Gly Gly 
        355                 360                 365             


Ser Ser Ser Asp Lys Pro Val Ala His Val Val Ala Asn His Gln Val 
    370                 375                 380                 


Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala 
385                 390                 395                 400 


Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala Asp Gly 
                405                 410                 415     


Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro 
            420                 425                 430         


Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile Ser Tyr 
        435                 440                 445             


Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys Pro Lys 
    450                 455                 460                 


Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr 
465                 470                 475                 480 


Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu 
                485                 490                 495     


Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr 
            500                 505                 510         


Phe Gly Val Ile Ala Leu 
        515             


<210>  93
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sc-mTNFR2

<400>  93

Ser Asp Lys Pro Val Ala His Val Val Ala Asn His Gln Val Glu Glu 
1               5                   10                  15      


Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly 
            20                  25                  30          


Met Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr 
        35                  40                  45              


Leu Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr 
    50                  55                  60                  


Val Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu 
65                  70                  75                  80  


Lys Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys Pro Lys Asp Thr 
                85                  90                  95      


Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly 
            100                 105                 110         


Gly Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu Val Asn 
        115                 120                 125             


Leu Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly 
    130                 135                 140                 


Val Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser Asp Lys Pro Val Ala 
145                 150                 155                 160 


His Val Val Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser 
                165                 170                 175     


Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn 
            180                 185                 190         


Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val 
        195                 200                 205             


Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr 
    210                 215                 220                 


Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser 
225                 230                 235                 240 


Ala Val Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu 
                245                 250                 255     


Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu 
            260                 265                 270         


Lys Gly Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn 
        275                 280                 285             


Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu Gly Gly 
    290                 295                 300                 


Gly Gly Ser Ser Ser Asp Lys Pro Val Ala His Val Val Ala Asn His 
305                 310                 315                 320 


Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu 
                325                 330                 335     


Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala 
            340                 345                 350         


Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
        355                 360                 365             


Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile 
    370                 375                 380                 


Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys 
385                 390                 395                 400 


Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro 
                405                 410                 415     


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser 
            420                 425                 430         


Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly Gln 
        435                 440                 445             


Val Tyr Phe Gly Val Ile Ala Leu 
    450                 455     


<210>  94
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  94

Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly 
1               5                   10                  15      


Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val 
        35                  40                  45              


Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu 
    50                  55                  60                  


Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser 
65                  70                  75                  80  


Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu 
                85                  90                  95      


Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn 
            100                 105     


<210>  95
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  95

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Ser Glu Phe Leu Ala 
            20                  25          


<210>  96
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  96

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Ser Gly Ile Arg 
            20                  25      


<210>  97
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHD2-scTNFR2

<400>  97

Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly 
1               5                   10                  15      


Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val 
        35                  40                  45              


Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu 
    50                  55                  60                  


Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser 
65                  70                  75                  80  


Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu 
                85                  90                  95      


Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Glu Phe Leu Ala Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala 
    130                 135                 140                 


His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn 
145                 150                 155                 160 


Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn 
                165                 170                 175     


Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val 
            180                 185                 190         


Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His 
        195                 200                 205             


Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu 
    210                 215                 220                 


Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu 
225                 230                 235                 240 


Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu 
                245                 250                 255     


Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu 
            260                 265                 270         


Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly 
        275                 280                 285             


Gly Gly Gly Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His 
    290                 295                 300                 


Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg 
305                 310                 315                 320 


Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln 
                325                 330                 335     


Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu 
            340                 345                 350         


Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr 
        355                 360                 365             


Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser 
    370                 375                 380                 


Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala 
385                 390                 395                 400 


Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu 
                405                 410                 415     


Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn 
            420                 425                 430         


Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu Gly Gly 
        435                 440                 445             


Gly Gly Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
    450                 455                 460                 


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
465                 470                 475                 480 


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
                485                 490                 495     


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
            500                 505                 510         


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
        515                 520                 525             


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
    530                 535                 540                 


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
545                 550                 555                 560 


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
                565                 570                 575     


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asn Phe 
            580                 585                 590         


Arg Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
        595                 600                 605 


<210>  98
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EHD2-sc-mTNFR2

<400>  98

Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly 
1               5                   10                  15      


Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val 
        35                  40                  45              


Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu 
    50                  55                  60                  


Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser 
65                  70                  75                  80  


Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu 
                85                  90                  95      


Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Ile Arg Ser Asp Lys Pro Val Ala His Val Val Ala Asn His 
    130                 135                 140                 


Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu 
145                 150                 155                 160 


Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu Val Val Pro Ala 
                165                 170                 175     


Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
            180                 185                 190         


Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser Arg Phe Ala Ile 
        195                 200                 205             


Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val Lys Ser Pro Cys 
    210                 215                 220                 


Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro 
225                 230                 235                 240 


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser 
                245                 250                 255     


Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg Glu Ser Gly Gln 
            260                 265                 270         


Val Tyr Phe Gly Val Ile Ala Leu Gly Gly Gly Gly Ser Ser Ser Asp 
        275                 280                 285             


Lys Pro Val Ala His Val Val Ala Asn His Gln Val Glu Glu Gln Leu 
    290                 295                 300                 


Glu Trp Leu Ser Gln Arg Ala Asn Ala Leu Leu Ala Asn Gly Met Asp 
305                 310                 315                 320 


Leu Lys Asp Asn Gln Leu Val Val Pro Ala Asp Gly Leu Tyr Leu Val 
                325                 330                 335     


Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu 
            340                 345                 350         


Leu Thr His Thr Val Ser Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val 
        355                 360                 365             


Asn Leu Leu Ser Ala Val Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu 
    370                 375                 380                 


Gly Ala Glu Leu Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val 
385                 390                 395                 400 


Phe Gln Leu Glu Lys Gly Asp Gln Leu Ser Ala Glu Val Asn Leu Pro 
                405                 410                 415     


Lys Tyr Leu Asn Phe Arg Glu Ser Gly Gln Val Tyr Phe Gly Val Ile 
            420                 425                 430         


Ala Leu Gly Gly Gly Gly Ser Ser Ser Asp Lys Pro Val Ala His Val 
        435                 440                 445             


Val Ala Asn His Gln Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg 
    450                 455                 460                 


Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu 
465                 470                 475                 480 


Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe 
                485                 490                 495     


Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser 
            500                 505                 510         


Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val 
        515                 520                 525             


Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro 
    530                 535                 540                 


Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly 
545                 550                 555                 560 


Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asn Phe Arg 
                565                 570                 575     


Glu Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
            580                 585             


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  99

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10  


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker

<400>  100

Gly Gly Ser Gly Gly Gly Ser Ser Gly Gly 
1               5                   10  


