               SEQUENCE LISTING

<110> Covagen AG

<120> FGFR3 binding molecules

<130> COV5008EP

<160> 22

<170> BiSSAP 1.3

<210> 1
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> Consensus sequence anti-FGFR3 Fynomers

<220> 
<221> VARIANT
<222> 32
<223> any amino acid

<220> 
<221> VARIANT
<222> 33
<223> any amino acid

<220> 
<221> VARIANT
<222> 34
<223> any amino acid

<220> 
<221> VARIANT
<222> 35
<223> any amino acid

<220> 
<221> VARIANT
<222> 45
<223> any amino acid

<220> 
<221> VARIANT
<222> 51
<223> any amino acid

<400> 1
Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Val Tyr Gly Pro 
1               5                   10                  15      
Thr Pro Met Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Xaa 
            20                  25                  30          
Xaa Xaa Xaa Gly Pro Tyr Trp Glu Ala Arg Ser Leu Xaa Thr Gly Glu 
        35                  40                  45              
Thr Gly Xaa Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  



<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> RT-loop sequence

<400> 2
Glu Val Tyr Gly Pro Thr Pro Met 
1               5               

<210> 3
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> FF2L4C3

<400> 3
Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Val Tyr Gly Pro 
1               5                   10                  15      
Thr Pro Met Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Asn 
            20                  25                  30          
Ser Ser Glu Gly Pro Tyr Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              
Thr Gly Leu Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  



<210> 4
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> FF44L65G12

<400> 4
Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Val Tyr Gly Pro 
1               5                   10                  15      
Thr Pro Met Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Arg 
            20                  25                  30          
Gly Gly Gln Gly Pro Tyr Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              
Thr Gly Leu Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  



<210> 5
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> FF44L65G7

<400> 5
Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Val Tyr Gly Pro 
1               5                   10                  15      
Thr Pro Met Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Arg 
            20                  25                  30          
Gly Gly Asp Gly Pro Tyr Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              
Thr Gly Leu Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  



<210> 6
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> FF48L66G7

<400> 6
Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Val Tyr Gly Pro 
1               5                   10                  15      
Thr Pro Met Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Lys 
            20                  25                  30          
Gly Gly Ser Gly Pro Tyr Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              
Thr Gly Leu Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  



<210> 7
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> FF43L65D5

<400> 7
Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Val Tyr Gly Pro 
1               5                   10                  15      
Thr Pro Met Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Arg 
            20                  25                  30          
Lys Gly Lys Gly Pro Tyr Trp Glu Ala Arg Ser Leu Ala Thr Gly Glu 
        35                  40                  45              
Thr Gly Leu Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  



<210> 8
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> FF44L65B7

<400> 8
Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Val Tyr Gly Pro 
1               5                   10                  15      
Thr Pro Met Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Arg 
            20                  25                  30          
Arg Gly Ser Gly Pro Tyr Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              
Thr Gly Leu Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  



<210> 9
<211> 357
<212> PRT
<213> Homo sapiens

<220> 
<223> FGFR3, isoform b

<400> 9
Ile Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala 
1               5                   10                  15      
Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly 
            20                  25                  30          
Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro 
        35                  40                  45              
Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser 
    50                  55                  60                  
Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser 
65                  70                  75                  80  
His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg 
                85                  90                  95      
Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly 
            100                 105                 110         
Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr 
        115                 120                 125             
Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu 
    130                 135                 140                 
Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly 
145                 150                 155                 160 
Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg 
                165                 170                 175     
Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser 
            180                 185                 190         
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys 
        195                 200                 205             
Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp 
    210                 215                 220                 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
225                 230                 235                 240 
Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys 
                245                 250                 255     
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu 
            260                 265                 270         
Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val 
        275                 280                 285             
Leu Lys Ser Trp Ile Ser Glu Ser Val Glu Ala Asp Val Arg Leu Arg 
    290                 295                 300                 
Leu Ala Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr Leu Cys Arg Ala 
305                 310                 315                 320 
Thr Asn Phe Ile Gly Val Ala Glu Lys Ala Phe Trp Leu Ser Val His 
                325                 330                 335     
Gly Pro Arg Ala Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly 
            340                 345                 350         
Ser Val Tyr Ala Gly 
        355         

<210> 10
<211> 355
<212> PRT
<213> Homo sapiens

<220> 
<223> FGFR3, isoform c

<400> 10
Ile Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala 
1               5                   10                  15      
Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly 
            20                  25                  30          
Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro 
        35                  40                  45              
Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser 
    50                  55                  60                  
Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser 
65                  70                  75                  80  
His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg 
                85                  90                  95      
Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly 
            100                 105                 110         
Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr 
        115                 120                 125             
Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu 
    130                 135                 140                 
Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly 
145                 150                 155                 160 
Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg 
                165                 170                 175     
Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser 
            180                 185                 190         
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys 
        195                 200                 205             
Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp 
    210                 215                 220                 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
225                 230                 235                 240 
Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys 
                245                 250                 255     
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu 
            260                 265                 270         
Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val 
        275                 280                 285             
Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu 
    290                 295                 300                 
Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu 
305                 310                 315                 320 
Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val 
                325                 330                 335     
Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val 
            340                 345                 350         
Tyr Ala Gly 
        355 

<210> 11
<211> 63
<212> PRT
<213> Homo sapiens

<220> 
<223> Fyn kinase SH3 domain

<400> 11
Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Glu 
1               5                   10                  15      
Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Asn Ser 
            20                  25                  30          
Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu Thr 
        35                  40                  45              
Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60              

<210> 12
<211> 586
<212> PRT
<213> Artificial Sequence

<220> 
<223> huFGFR3b-Fc

<400> 12
Ile Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala 
1               5                   10                  15      
Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly 
            20                  25                  30          
Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro 
        35                  40                  45              
Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser 
    50                  55                  60                  
Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser 
65                  70                  75                  80  
His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg 
                85                  90                  95      
Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly 
            100                 105                 110         
Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr 
        115                 120                 125             
Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu 
    130                 135                 140                 
Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly 
145                 150                 155                 160 
Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg 
                165                 170                 175     
Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser 
            180                 185                 190         
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys 
        195                 200                 205             
Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp 
    210                 215                 220                 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
225                 230                 235                 240 
Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys 
                245                 250                 255     
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu 
            260                 265                 270         
Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val 
        275                 280                 285             
Leu Lys Ser Trp Ile Ser Glu Ser Val Glu Ala Asp Val Arg Leu Arg 
    290                 295                 300                 
Leu Ala Asn Val Ser Glu Arg Asp Gly Gly Glu Tyr Leu Cys Arg Ala 
305                 310                 315                 320 
Thr Asn Phe Ile Gly Val Ala Glu Lys Ala Phe Trp Leu Ser Val His 
                325                 330                 335     
Gly Pro Arg Ala Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly 
            340                 345                 350         
Ser Val Tyr Ala Gly Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
        355                 360                 365             
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    370                 375                 380                 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
385                 390                 395                 400 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                405                 410                 415     
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            420                 425                 430         
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        435                 440                 445             
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    450                 455                 460                 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
465                 470                 475                 480 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
                485                 490                 495     
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            500                 505                 510         
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        515                 520                 525             
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    530                 535                 540                 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
545                 550                 555                 560 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                565                 570                 575     
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585     

<210> 13
<211> 584
<212> PRT
<213> Artificial Sequence

<220> 
<223> huFGFR3c-Fc

<400> 13
Ile Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala 
1               5                   10                  15      
Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly 
            20                  25                  30          
Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro 
        35                  40                  45              
Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser 
    50                  55                  60                  
Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser 
65                  70                  75                  80  
His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg 
                85                  90                  95      
Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly 
            100                 105                 110         
Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr 
        115                 120                 125             
Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu 
    130                 135                 140                 
Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly 
145                 150                 155                 160 
Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg 
                165                 170                 175     
Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser 
            180                 185                 190         
Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys 
        195                 200                 205             
Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp 
    210                 215                 220                 
Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
225                 230                 235                 240 
Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys 
                245                 250                 255     
Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu 
            260                 265                 270         
Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val 
        275                 280                 285             
Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu 
    290                 295                 300                 
Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu 
305                 310                 315                 320 
Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val 
                325                 330                 335     
Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val 
            340                 345                 350         
Tyr Ala Gly Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        355                 360                 365             
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    370                 375                 380                 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
385                 390                 395                 400 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                405                 410                 415     
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            420                 425                 430         
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        435                 440                 445             
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    450                 455                 460                 
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
465                 470                 475                 480 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                485                 490                 495     
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            500                 505                 510         
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        515                 520                 525             
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    530                 535                 540                 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
545                 550                 555                 560 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                565                 570                 575     
Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 

<210> 14
<211> 583
<212> PRT
<213> Artificial Sequence

<220> 
<223> cyFGFR3c-Fc

<400> 14
Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Val Ala Glu 
1               5                   10                  15      
Val Ser Gly Pro Glu Pro Ser Gln Gln Glu Gln Leu Val Phe Gly Ser 
            20                  25                  30          
Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met 
        35                  40                  45              
Gly Pro Thr Val Trp Val Lys Asp Gly Ala Gly Leu Val Pro Ser Glu 
    50                  55                  60                  
Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His 
65                  70                  75                  80  
Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Leu Val 
                85                  90                  95      
Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp 
            100                 105                 110         
Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly 
        115                 120                 125             
Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala 
    130                 135                 140                 
Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn 
145                 150                 155                 160 
Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly 
                165                 170                 175     
Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu 
            180                 185                 190         
Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val 
        195                 200                 205             
Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val 
    210                 215                 220                 
Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala 
225                 230                 235                 240 
Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val 
                245                 250                 255     
Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val 
            260                 265                 270         
Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu 
        275                 280                 285             
Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser 
    290                 295                 300                 
Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala 
305                 310                 315                 320 
Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu 
                325                 330                 335     
Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr 
            340                 345                 350         
Ala Gly Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                405                 410                 415     
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            420                 425                 430         
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    450                 455                 460                 
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
                485                 490                 495     
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    530                 535                 540                 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
545                 550                 555                 560 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     
Leu Ser Leu Ser Pro Gly Lys 
            580             

<210> 15
<211> 347
<212> PRT
<213> Artificial Sequence

<220> 
<223> muFGFR3c-His

<400> 15
Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Gln Gln Glu Gln Val Ala 
1               5                   10                  15      
Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys His Pro Pro Gly Gly 
            20                  25                  30          
Ala Pro Thr Gly Pro Thr Val Trp Ala Lys Asp Gly Thr Gly Leu Val 
        35                  40                  45              
Ala Ser His Arg Ile Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn 
    50                  55                  60                  
Ala Ser His Glu Asp Ala Gly Val Tyr Ser Cys Gln His Arg Leu Thr 
65                  70                  75                  80  
Arg Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser 
                85                  90                  95      
Ser Gly Asp Asp Glu Asp Gly Glu Asp Val Ala Glu Asp Thr Gly Ala 
            100                 105                 110         
Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
        115                 120                 125             
Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
    130                 135                 140                 
Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu 
145                 150                 155                 160 
His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
                165                 170                 175     
Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
            180                 185                 190         
Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
        195                 200                 205             
Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
    210                 215                 220                 
Gln Thr Ala Ile Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
225                 230                 235                 240 
Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
                245                 250                 255     
Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
            260                 265                 270         
Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
        275                 280                 285             
His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
    290                 295                 300                 
Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
305                 310                 315                 320 
Ala Glu Glu Glu Leu Met Glu Thr Asp Glu Ala Gly Ser Val Tyr Ala 
                325                 330                 335     
Gly His His His His His His His His His His 
            340                 345         

<210> 16
<211> 361
<212> PRT
<213> Artificial Sequence

<220> 
<223> huD1-Fc

<400> 16
Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu 
1               5                   10                  15      
Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser 
            20                  25                  30          
Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met 
        35                  40                  45              
Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu 
    50                  55                  60                  
Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His 
65                  70                  75                  80  
Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val 
                85                  90                  95      
Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp 
            100                 105                 110         
Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly 
        115                 120                 125             
Ala Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            260                 265                 270         
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360     

<210> 17
<211> 340
<212> PRT
<213> Artificial Sequence

<220> 
<223> huD2-Fc

<400> 17
Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala 
1               5                   10                  15      
Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn 
            20                  25                  30          
Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly 
        35                  40                  45              
Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu 
    50                  55                  60                  
Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val 
65                  70                  75                  80  
Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val 
                85                  90                  95      
Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        115                 120                 125             
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    130                 135                 140                 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
145                 150                 155                 160 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                165                 170                 175     
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            180                 185                 190         
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        195                 200                 205             
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    210                 215                 220                 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
225                 230                 235                 240 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                245                 250                 255     
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            260                 265                 270         
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        275                 280                 285             
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    290                 295                 300                 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
305                 310                 315                 320 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                325                 330                 335     
Ser Pro Gly Lys 
            340 

<210> 18
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> huD1-D2-Fc

<400> 18
Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu 
1               5                   10                  15      
Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser 
            20                  25                  30          
Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met 
        35                  40                  45              
Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu 
    50                  55                  60                  
Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His 
65                  70                  75                  80  
Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val 
                85                  90                  95      
Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp 
            100                 105                 110         
Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly 
        115                 120                 125             
Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala 
    130                 135                 140                 
Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn 
145                 150                 155                 160 
Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly 
                165                 170                 175     
Glu His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu 
            180                 185                 190         
Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val 
        195                 200                 205             
Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val 
    210                 215                 220                 
Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 19
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> Consensus sequence anti-FGFR3 Fynomers

<220> 
<221> VARIANT
<222> 51
<223> any amino acid

<400> 19
Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Val Met Ser Thr 
1               5                   10                  15      
Thr Ala Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Ser Gln 
            20                  25                  30          
Ser Pro His Gly Gln Tyr Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              
Thr Gly Xaa Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  



<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> RT-loop sequence

<400> 20
Glu Val Met Ser Thr Thr Ala 
1               5           

<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> src-loop sequence

<400> 21
Ser Gln Ser Pro His 
1               5   

<210> 22
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> FF40L54A5

<400> 22
Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Val Met Ser Thr 
1               5                   10                  15      
Thr Ala Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu Ser Gln 
            20                  25                  30          
Ser Pro His Gly Gln Tyr Trp Glu Ala Arg Ser Leu Thr Thr Gly Glu 
        35                  40                  45              
Thr Gly Trp Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile Gln 
    50                  55                  60                  



