                         SEQUENCE LISTING

<110>  The BROAD Institute
       Massachusetts Institute of Technology
       Dana-Farber Cancer Institute, Inc.
       Izar, Benjamin
       Rotem, Asaf
       Regev, Aviv
       Rozenblatt-Rosen, Orit
 
<120>  Compositions and Methods for Treating Ovarian Tumors

<130>  BROD-2321WP

<150>  US 62/479,885
<151>  2017-03-31

<150>  US 62/565,470
<151>  2017-09-29

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210>  2
<211>  4978
<212>  DNA
<213>  Homo sapiens

<400>  2
ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag       60

ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc      120

ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg      180

cgcagccccg gcctctcggc ctctgccgga gaaacagttg ggacccctga ttttagcagg      240

atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag      300

ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt      360

caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc      420

ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag      480

cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag      540

attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc      600

actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag      660

cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag      720

aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag      780

agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg      840

cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag      900

ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg      960

gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta     1020

gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa     1080

attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag     1140

caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc     1200

tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag     1260

accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat     1320

cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga     1380

tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac     1440

aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat     1500

gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc     1560

tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca     1620

gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac     1680

aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc     1740

tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg     1800

agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca     1860

gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc     1920

ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg     1980

aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact     2040

aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact     2100

ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac     2160

acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg     2220

gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag     2280

gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggt     2340

agcgctgccc catacctgaa gaccaagttt atctgtgtga caccaacgac ctgcagcaat     2400

accattgacc tgccgatgtc cccccgcact ttagattcat tgatgcagtt tggaaataat     2460

ggtgaaggtg ctgaaccctc agcaggaggg cagtttgagt ccctcacctt tgacatggag     2520

ttgacctcgg agtgcgctac ctcccccatg tgaggagctg agaacggaag ctgcagaaag     2580

atacgactga ggcgcctacc tgcattctgc cacccctcac acagccaaac cccagatcat     2640

ctgaaactac taactttgtg gttccagatt ttttttaatc tcctacttct gctatctttg     2700

agcaatctgg gcacttttaa aaatagagaa atgagtgaat gtgggtgatc tgcttttatc     2760

taaatgcaaa taaggatgtg ttctctgaga cccatgatca ggggatgtgg cggggggtgg     2820

ctagagggag aaaaaggaaa tgtcttgtgt tgttttgttc ccctgccctc ctttctcagc     2880

agctttttgt tattgttgtt gttgttctta gacaagtgcc tcctggtgcc tgcggcatcc     2940

ttctgcctgt ttctgtaagc aaatgccaca ggccacctat agctacatac tcctggcatt     3000

gcacttttta accttgctga catccaaata gaagatagga ctatctaagc cctaggtttc     3060

tttttaaatt aagaaataat aacaattaaa gggcaaaaaa cactgtatca gcatagcctt     3120

tctgtattta agaaacttaa gcagccgggc atggtggctc acgcctgtaa tcccagcact     3180

ttgggaggcc gaggcggatc ataaggtcag gagatcaaga ccatcctggc taacacggtg     3240

aaaccccgtc tctactaaaa gtacaaaaaa ttagctgggt gtggtggtgg gcgcctgtag     3300

tcccagctac tcgggaggct gaggcaggag aatcgcttga acctgagagg cggaggttgc     3360

agtgagccaa aattgcacca ctgcacactg cactccatcc tgggcgacag tctgagactc     3420

tgtctcaaaa aaaaaaaaaa aaaaaagaaa cttcagttaa cagcctcctt ggtgctttaa     3480

gcattcagct tccttcaggc tggtaattta tataatccct gaaacgggct tcaggtcaaa     3540

cccttaagac atctgaagct gcaacctggc ctttggtgtt gaaataggaa ggtttaagga     3600

gaatctaagc attttagact tttttttata aatagactta ttttcctttg taatgtattg     3660

gccttttagt gagtaaggct gggcagaggg tgcttacaac cttgactccc tttctccctg     3720

gacttgatct gctgtttcag aggctaggtt gtttctgtgg gtgccttatc agggctggga     3780

tacttctgat tctggcttcc ttcctgcccc accctcccga ccccagtccc cctgatcctg     3840

ctagaggcat gtctccttgc gtgtctaaag gtccctcatc ctgtttgttt taggaatcct     3900

ggtctcagga cctcatggaa gaagaggggg agagagttac aggttggaca tgatgcacac     3960

tatggggccc cagcgacgtg tctggttgag ctcagggaat atggttctta gccagtttct     4020

tggtgatatc cagtggcact tgtaatggcg tcttcattca gttcatgcag ggcaaaggct     4080

tactgataaa cttgagtctg ccctcgtatg agggtgtata cctggcctcc ctctgaggct     4140

ggtgactcct ccctgctggg gccccacagg tgaggcagaa cagctagagg gcctccccgc     4200

ctgcccgcct tggctggcta gctcgcctct cctgtgcgta tgggaacacc tagcacgtgc     4260

tggatgggct gcctctgact cagaggcatg gccggatttg gcaactcaaa accaccttgc     4320

ctcagctgat cagagtttct gtggaattct gtttgttaaa tcaaattagc tggtctctga     4380

attaaggggg agacgacctt ctctaagatg aacagggttc gccccagtcc tcctgcctgg     4440

agacagttga tgtgtcatgc agagctctta cttctccagc aacactcttc agtacataat     4500

aagcttaact gataaacaga atatttagaa aggtgagact tgggcttacc attgggttta     4560

aatcataggg acctagggcg agggttcagg gcttctctgg agcagatatt gtcaagttca     4620

tggccttagg tagcatgtat ctggtcttaa ctctgattgt agcaaaagtt ctgagaggag     4680

ctgagccctg ttgtggccca ttaaagaaca gggtcctcag gccctgcccg cttcctgtcc     4740

actgccccct ccccatcccc agcccagccg agggaatccc gtgggttgct tacctaccta     4800

taaggtggtt tataagctgc tgtcctggcc actgcattca aattccaatg tgtacttcat     4860

agtgtaaaaa tttatattat tgtgaggttt tttgtctttt tttttttttt ttttttttgg     4920

tatattgctg tatctacttt aacttccaga aataaacgtt atataggaac cgtaaaaa       4978


<210>  3
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ser Gly Gly Gly Gly Ser Glu Gly Ala Pro Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Gly Ser Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly Asp 
            20                  25                  30          


Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu Ile 
        35                  40                  45              


Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys 
    50                  55                  60                  


Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly 
65                  70                  75                  80  


Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr Ile 
                85                  90                  95      


Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser 
            100                 105                 110         


Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe Glu 
        115                 120                 125             


Asn Pro Lys Gln Gly Lys Leu Arg Thr Lys Val Glu Asn Gly Gln Gly 
    130                 135                 140                 


Thr Ile Pro Val Glu Ser Ser Asp Ile Val Pro Thr Trp Asp Gly Ile 
145                 150                 155                 160 


Arg Leu Gly Glu Arg Leu Arg Thr Met Ser Cys Ser Asp Lys Ile Leu 
                165                 170                 175     


Arg Trp Asn Val Leu Gly Leu Gln Gly Ala Leu Leu Thr His Phe Leu 
            180                 185                 190         


Gln Pro Ile Tyr Leu Lys Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln 
        195                 200                 205             


Gly His Leu Thr Arg Ala Ile Cys Cys Arg Val Thr Arg Asp Gly Ser 
    210                 215                 220                 


Ala Phe Glu Asp Gly Leu Arg His Pro Phe Ile Val Asn His Pro Lys 
225                 230                 235                 240 


Val Gly Arg Val Ser Ile Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr 
                245                 250                 255     


Lys Glu Thr Ser Val Asn Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu 
            260                 265                 270         


Ile Leu Asp Gly Thr Arg Gly Thr Val Asp Gly Pro Arg Asn Glu Leu 
        275                 280                 285             


Ser Arg Val Ser Lys Lys Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys 
    290                 295                 300                 


Ser Phe Arg Tyr Arg Arg Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala 
305                 310                 315                 320 


Lys Lys Ala Ala Arg Asp Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys 
                325                 330                 335     


Gly Leu Lys Asp Met Gly Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu 
            340                 345                 350         


Glu Lys Asn Phe 
        355     


<210>  4
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Asp Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu 
1               5                   10                  15      


Ser Gly Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly Val 
            20                  25                  30          


Ser Pro Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr 
        35                  40                  45              


Met Ser Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe 
    50                  55                  60                  


Ser Ala Asp Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu 
65                  70                  75                  80  


Phe Asn Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His His 
                85                  90                  95      


Thr Glu Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu Arg 
            100                 105                 110         


Ala Ala Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala Ala 
        115                 120                 125             


Arg Pro Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro 
    130                 135                 140                 


Ser Asp Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr 
145                 150                 155                 160 


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 
                165                 170                 175     


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
            180                 185                 190         


Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 
        195                 200                 205             


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 
    210                 215                 220                 


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
225                 230                 235                 240 


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
                245                 250                 255     


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
            260                 265                 270         


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
        275                 280                 285             


<210>  5
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro 
1               5                   10                  15      


Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu 
            20                  25                  30          


Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala 
        35                  40                  45              


Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr Ser 
    50                  55                  60                  


His Arg Val Ala Asp His Ala Gln Val Val Arg Val Leu Gly Phe Phe 
65                  70                  75                  80  


Gln Cys His Ser His Pro Ala Gln Ala Phe Asp Asp Ala Met Thr Gln 
                85                  90                  95      


Phe Gly Met Ser Arg His Gly Leu Leu Gln Leu Phe Arg Arg Val Gly 
            100                 105                 110         


Val Thr Glu Leu Glu Ala Arg Ser Gly Thr Leu Pro Pro Ala Ser Gln 
        115                 120                 125             


Arg Trp Asp Arg Ile Leu Gln Ala Ser Gly Met Lys Arg Ala Lys Pro 
    130                 135                 140                 


Ser Pro Thr Ser Thr Gln Thr Pro Asp Gln Ala Ser Leu His Ala Phe 
145                 150                 155                 160 


Ala Asp Ser Leu Glu Arg Asp Leu Asp Ala Pro Ser Pro Met His Glu 
                165                 170                 175     


Gly Asp Gln Thr Arg Ala Ser 
            180             


<210>  6
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Ile Glu Val Met Tyr Pro Pro Pro Tyr 
1               5                   


<210>  8
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


