                         SEQUENCE LISTING

<110>  THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR 
       UNIVERSITY
 
<120>  METHODS OF MITIGATING T CELL EXHAUSTION BY MODULATING OR 
       INHIBITING T CELL RECEPTOR SIGNALING AND/OR CHIMERIC ANTIGEN 
       RECEPTOR SIGNALING

<130>  STDU2-36278/WO-1/ORD

<150>  US 62/479,930
<151>  2017-03-31

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1
atgacaagag ttactaacag cccctctctc caagctcact tacaggctct ctacttagtc       60

cagcacgaag tctggagacc tctggcggca gcctaccaag aacaactgga ccgaccggtg      120

gtacctcacc cttaccgagt cggcgacaca gtgtgggtcc gccgacacca gactaagaac      180

ctagaacctc gctggaaagg accttacaca gtcctgctga ccacccccac cgccctcaaa      240

gtagacggca tcgcagcttg gatacacgcc gcccacgtga aggctgccga ccccgggggt      300

ggaccatcct ctagactgct cgagatgctt ctcctggtga caagccttct gctctgtgag      360

ttaccacacc cagcattcct cctgatccca gacatccaga tgacacagac tacatcctcc      420

ctgtctgcct ctctgggaga cagagtcacc atcagttgca gggcaagtca ggacattagt      480

aaatatttaa attggtatca gcagaaacca gatggaactg ttaaactcct gatctaccat      540

acatcaagat tacactcagg agtcccatca aggttcagtg gcagtgggtc tggaacagat      600

tattctctca ccattagcaa cctggagcaa gaagatattg ccacttactt ttgccaacag      660

ggtaatacgc ttccgtacac gttcggaggg gggactaagt tggaaataac aggctccacc      720

tctggatccg gcaagcccgg atctggcgag ggatccacca agggcgaggt gaaactgcag      780

gagtcaggac ctggcctggt ggcgccctca cagagcctgt ccgtcacatg cactgtctca      840

ggggtctcat tacccgacta tggtgtaagc tggattcgcc agcctccacg aaagggtctg      900

gagtggctgg gagtaatatg gggtagtgaa accacatact ataattcagc tctcaaatcc      960

agactgacca tcatcaagga caactccaag agccaagttt tcttaaaaat gaacagtctg     1020

caaactgatg acacagccat ttactactgt gccaaacatt attactacgg tggtagctat     1080

gctatggact actggggtca aggaacctca gtcaccgtct cctcagcggc cgcaattgaa     1140

gttatgtatc ctcctcctta cctagacaat gagaagagca atggaaccat tatccatgtg     1200

aaagggaaac acctttgtcc aagtccccta tttcccggac cttctaagcc cttttgggtg     1260

ctggtggtgg ttgggggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt     1320

attttctggg tgaggagtaa gaggagcagg ctcctgcaca gtgactacat gaacatgact     1380

ccccgccgcc ccgggcccac ccgcaagcat taccagccct atgccccacc acgcgacttc     1440

gcagcctatc gctccagagt gaagttcagc aggagcgcag acgcccccgc gtaccagcag     1500

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1560

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1620

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1680

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1740

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1794


<210>  2
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Met Thr Arg Val Thr Asn Ser Pro Ser Leu Gln Ala His Leu Gln Ala 
1               5                   10                  15      


Leu Tyr Leu Val Gln His Glu Val Trp Arg Pro Leu Ala Ala Ala Tyr 
            20                  25                  30          


Gln Glu Gln Leu Asp Arg Pro Val Val Pro His Pro Tyr Arg Val Gly 
        35                  40                  45              


Asp Thr Val Trp Val Arg Arg His Gln Thr Lys Asn Leu Glu Pro Arg 
    50                  55                  60                  


Trp Lys Gly Pro Tyr Thr Val Leu Leu Thr Thr Pro Thr Ala Leu Lys 
65                  70                  75                  80  


Val Asp Gly Ile Ala Ala Trp Ile His Ala Ala His Val Lys Ala Ala 
                85                  90                  95      


Asp Pro Gly Gly Gly Pro Ser Ser Arg Leu Leu Glu Met Leu Leu Leu 
            100                 105                 110         


Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu 
        115                 120                 125             


Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
145                 150                 155                 160 


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
                165                 170                 175     


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
        195                 200                 205             


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr 
225                 230                 235                 240 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
                245                 250                 255     


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
            260                 265                 270         


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
        275                 280                 285             


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
    290                 295                 300                 


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
305                 310                 315                 320 


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
                325                 330                 335     


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
            340                 345                 350         


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Ser Val Thr Val Ser Ser Ala Ala Ala Ile Glu Val Met Tyr Pro 
    370                 375                 380                 


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
385                 390                 395                 400 


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
                405                 410                 415     


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            420                 425                 430         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
        435                 440                 445             


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
    450                 455                 460                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
465                 470                 475                 480 


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                485                 490                 495     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            500                 505                 510         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        515                 520                 525             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    530                 535                 540                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
545                 550                 555                 560 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                565                 570                 575     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            580                 585                 590         


Ala Leu Pro Pro Arg 
        595         


<210>  3
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga      120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag      180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc      240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg      300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc      360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct      420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg      480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt      540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt      600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac      660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac      720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga      780

acctcagtca ccgtctcctc agcggccgca accacgacgc cagcgccgcg accaccaaca      840

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      900

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      960

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa     1020

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     1080

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     1140

ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag     1200

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1260

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac     1320

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1380

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1440

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                        1482


<210>  4
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  5
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
atgctgctgc tcgtgacatc tctgctgctg tgcgagctgc cccaccccgc ctttctgctg       60

atccccgata tcctgctgac ccagacccct ctgagcctgc ctgtgtctct gggcgatcag      120

gccagcatca gctgcagatc cagccagagc ctggtgcacc ggaacggcaa cacctacctg      180

cactggtatc tgcagaagcc cggccagagc cccaagctgc tgattcacaa ggtgtccaac      240

cggttcagcg gcgtgcccga cagattttct ggcagcggct ccggcaccga cttcaccctg      300

aagatcagcc gggtggaagc cgaggacctg ggcgtgtact tctgcagcca gtccacccac      360

gtgccccccc tgacatttgg cgccggaaca aagctggaac tgaagggcag cacaagcggc      420

agcggcaagc ctggatctgg cgagggaagc accaagggcg aagtgaagct gcagcagagc      480

ggcccctctc tggtggaacc tggcgcctct gtgatgatct cctgcaaggc cagcggcagc      540

tccttcaccg gctacaacat gaactgggtg cgccagaaca tcggcaagag cctggaatgg      600

atcggcgcca tcgaccccta ctacggcggc accagctaca accagaagtt caagggcaga      660

gccaccctga ccgtggacaa gagcagctcc accgcctaca tgcacctgaa gtccctgacc      720

agcgaggaca gcgccgtgta ctactgcgtg tccggcatgg aatactgggg ccagggcaca      780

agcgtgaccg tgtcctctgc ggccgcaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                            1479


<210>  6
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Leu Leu Thr Gln Thr Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala 
        115                 120                 125             


Gly Thr Lys Leu Glu Leu Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
    130                 135                 140                 


Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Pro Ser Leu Val Glu Pro Gly Ala Ser Val Met Ile Ser Cys Lys 
                165                 170                 175     


Ala Ser Gly Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln 
            180                 185                 190         


Asn Ile Gly Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr 
        195                 200                 205             


Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr 
    210                 215                 220                 


Val Asp Lys Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  7
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
atggaattcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgcagc       60

agagatatcc tgctgaccca gacccctctg agcctgcctg tgtctctggg cgatcaggcc      120

agcatcagct gcagatccag ccagagcctg gtgcaccgga acggcaacac ctacctgcac      180

tggtatctgc agaagcccgg ccagagcccc aagctgctga tccacaaggt gtccaaccgg      240

ttcagcggcg tgcccgacag attttctggc agcggctccg gcaccgactt caccctgaag      300

atcagccggg tggaagccga ggacctgggc gtgtacttct gcagccagtc cacccacgtg      360

ccccccctga catttggcgc cggaacaaag ctggaactga aggggggagg cggatctggc      420

ggcggaggaa gtggcggagg gggatctgaa gtgaagctgc agcagtccgg ccccagcctg      480

gtggaacctg gcgcctctgt gatgatctcc tgcaaggcca gcggcagctc cttcaccggc      540

tacaacatga actgggtgcg ccagaacatc ggcaagagcc tggaatggat cggcgccatc      600

gacccctact acggcggcac cagctacaac cagaagttca agggcagagc caccctgacc      660

gtggacaaga gcagcagcac cgcctacatg cacctgaagt ccctgaccag cgaggacagc      720

gccgtgtact actgcgtgtc cggcatgaag tactggggcc agggcacaag cgtgaccgtg      780

tctagcgcca agaccacccc ccctagcgtg tacggaagag tgacagtgtc ctctgccgag      840

cccaagagct gcgacaagac ccacacctgt cccccttgtc ctgcccctga gctgctggga      900

ggcccttccg tgttcctgtt ccccccaaag cccaaggaca cactgatgat cagcagaacc      960

cccgaagtga cctgcgtggt ggtggacgtg tcccacgagg acccagaagt gaagttcaat     1020

tggtacgtgg acggcgtgga agtgcacaac gccaagacaa agcccagaga ggaacagtac     1080

aacagcacct accgggtggt gtccgtgctg accgtgctgc atcaggattg gctgaacggc     1140

aaagagtaca agtgcaaagt gtccaacaag gccctgcctg cccccatcga gaaaaccatc     1200

agcaaggcca agggccagcc ccgcgaaccc caggtgtaca cactgccccc tagcagggac     1260

gagctgacca agaaccaggt gtccctgaca tgcctcgtga agggcttcta cccctccgat     1320

atcgccgtgg aatgggagag caacggccag cccgagaaca actacaagac aacccctccc     1380

gtgctggaca gcgacggctc attcttcctg tacagcaagc tgacagtgga taagtcccgg     1440

tggcagcagg gcaacgtgtt cagctgctcc gtgatgcacg aggccctgca caaccactac     1500

acccagaaaa gcctgtccct gagccccggc aagaaggacc ccaaagctag cttcgaaatt     1560

gaagttatgt atcctcctcc ttacctagac aatgagaaga gcaatggaac cattatccat     1620

gtgaaaggga aacacctttg tccaagtccc ctatttcccg gaccttctaa gcccttttgg     1680

gtgctggtgg tggttggggg agtcctggct tgctatagct tgctagtaac agtggccttt     1740

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg     1800

actccccgcc gccccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1860

ttcgcagcct atcgctccag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag     1920

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1980

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     2040

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     2100

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     2160

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa        2217


<210>  8
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Ser Arg Asp Ile Leu Leu Thr Gln Thr Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly 
        115                 120                 125             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Gln Ser Gly Pro Ser Leu 
145                 150                 155                 160 


Val Glu Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser 
                165                 170                 175     


Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys 
            180                 185                 190         


Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser 
        195                 200                 205             


Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Val Ser Gly Met Lys Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Gly 
            260                 265                 270         


Arg Val Thr Val Ser Ser Ala Glu Pro Lys Ser Cys Asp Lys Thr His 
        275                 280                 285             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    290                 295                 300                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
305                 310                 315                 320 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                325                 330                 335     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            340                 345                 350         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                405                 410                 415     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            420                 425                 430         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        435                 440                 445             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    450                 455                 460                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
465                 470                 475                 480 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                485                 490                 495     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys 
            500                 505                 510         


Asp Pro Lys Ala Ser Phe Glu Ile Glu Val Met Tyr Pro Pro Pro Tyr 
        515                 520                 525             


Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys 
    530                 535                 540                 


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
545                 550                 555                 560 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                565                 570                 575     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            580                 585                 590         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        595                 600                 605             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    610                 615                 620                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
625                 630                 635                 640 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                645                 650                 655     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            660                 665                 670         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        675                 680                 685             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    690                 695                 700                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
705                 710                 715                 720 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                725                 730                 735     


Pro Arg 
        


