                               SEQUENCE LISTING

<110> PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> METHODS OF REGULATING GENE EXPRESSION IN A CELL

<130> 010498.01066/WO

<140>
<141>

<150> 62/478,219
<151> 2017-03-29

<160> 27    

<170> PatentIn version 3.5

<210> 1
<211> 703
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
ttataaaaag atgttgacag cttgttctga tgatgataaa ctttaatagt tgcgagagaa       60

agaggagaaa tactagatga tgtctagatt agataaaagt aaagtgatta acagcgcatt      120

agagctgctt aatgaggtcg gaatcgaagg tttaacaacc cgtaaactcg cccagaagct      180

aggtgtagag cagcctacat tgtattggca tgtaaaaaat aagcgggctt tgctcgacgc      240

cttagccatt gagatgttag ataggcacca tactcacttt tgccctttag aaggggaaag      300

ctggcaagat tttttacgta ataacgctaa aagttttaga tgtgctttac taagtcatcg      360

cgatggagca aaagtacatt taggtacacg gcctacagaa aaacagtatg aaactctcga      420

aaatcaatta gcctttttat gccaacaagg tttttcacta gagaatgcat tatatgcact      480

cagcgctgtg gggcatttta ctttaggttg cgtattggaa gatcaagagc atcaagtcgc      540

taaagaagaa agggaaacac ctactactga tagtatgccg ccattattac gacaagctat      600

cgaattattt gatcaccaag gtgcagagcc agccttctta ttcggccttg aattgatcat      660

atgcggatta gaaaaacaac ttaaatgtga aagtgggtct taa                        703


<210> 2
<211> 287
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg ccctatcagt gatagagatc      120

aggcgcccta tcagtgatag agatgattct tcagcaagac tactacctca tgagagttat      180

agactcatgg atcttgcttt gaagggtttt gtacattata ggctcctatc acatgctgaa      240

cctatggcct attacatttt tttatatttc aaggaggaaa agaccac                    287


<210> 3
<211> 938
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
ccccttctac cataccccct ttacacctac tccacctcta tattccatcc tgcttgtggg       60

ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac ttgctatttc      120

ttgaagaggt tagtacaata tgaatcgtgg taagtaatag gacgtgcttc aggcgtgttg      180

cctgtacgca tgctgattct tcagcaagac tactacctca tgagagttat agactcatgg      240

tataggctcc tatcacatgc tgaacctatg gcctattaca tttttttata tttcaaggag      300

gaaaagacca catgatgtct agattagata aaagtaaagt gattaacagc gcattagagc      360

tgcttaatga ggtcggaatc gaaggtttaa caacccgtaa actcgcccag aagctaggtg      420

tagagcagcc tacattgtat tggcatgtaa aaaataagcg ggctttgctc gacgccttag      480

ccattgagat gttagatagg caccatactc acttttgccc tttagaaggg gaaagctggc      540

aagatttttt acgtaataac gctaaaagtt ttagatgtgc tttactaagt catcgcgatg      600

gagcaaaagt acatttaggt acacggccta cagaaaaaca gtatgaaact ctcgaaaatc      660

aattagcctt tttatgccaa caaggttttt cactagagaa tgcattatat gcactcagcg      720

ctgtggggca ttttacttta ggttgcgtat tggaagatca agagcatcaa gtcgctaaag      780

aagaaaggga aacacctact actgatagta tgccgccatt attacgacaa gctatcgaat      840

tatttgatca ccaaggtgca gagccagcct tcttattcgg ccttgaattg atcatatgcg      900

gattagaaaa acaacttaaa tgtgaaagtg ggtcttaa                              938


<210> 4
<211> 191
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
gtggtaagta ataggacgtg cttcaggcgt gttgcctgta cgcatgctga ttcttcagca       60

agactactac ctcatgagag ttatagactc atggatcttg ctttgaaggg ttttgtacat      120

tataggctcc tatcacatgc tgaacctatg gcctattaca tttttttata tttcaaggag      180

gaaaagacca c                                                           191


<210> 5
<211> 627
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atgatgtcac gcttggataa atcaaaagtt attaattcag cattggaatt gttgaatgaa       60

gttggcattg aaggcttgac cacccgcaaa ttggcacaaa aattgggcgt tgaacaacca      120

accttgtatt ggcatgttaa aaataaacgc gcattgttgg atgcattggc aattgaaatg      180

ttggatcgcc atcataccca tttttgccca ttggaaggcg aatcatggca agattttttg      240

cgcaataatg caaaatcatt tcgctgcgca ttgttgtcac atcgcgatgg cgcaaaagtt      300

catttgggca cccgcccaac cgaaaaacaa tatgaaacct tggaaaatca attggcattt      360

ttgtgccaac aaggcttttc attggaaaat gcattgtatg cattgtcagc agttggccat      420

tttaccttgg gctgcgtttt ggaagatcaa gaacatcaag ttgcaaaaga agaacgcgaa      480

accccaacca ccgattcaat gccaccattg ttgcgccaag caattgaatt gtttgatcat      540

caaggcgcag aaccagcatt tttgtttggc ttggaattga ttatttgcgg cttggaaaaa      600

caattgaaat gcgaatcagg ctcataa                                          627


<210> 6
<211> 693
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
cttaaaatat agtcatagaa ttagggcgtc ggttttaaaa gtgtggtaaa ataatggtca       60

agattaatga tgtctagatt agataaaagt aaagtgatta acagcgcatt agagctgctt      120

aatgaggtcg gaatcgaagg tttaacaacc cgtaaactcg cccagaagct aggtgtagag      180

cagcctacat tgtattggca tgtaaaaaat aagcgggctt tgctcgacgc cttagccatt      240

gagatgttag ataggcacca tactcacttt tgccctttag aaggggaaag ctggcaagat      300

tttttacgta ataacgctaa aagttttaga tgtgctttac taagtcatcg cgatggagca      360

aaagtacatt taggtacacg gcctacagaa aaacagtatg aaactctcga aaatcaatta      420

gcctttttat gccaacaagg tttttcacta gagaatgcat tatatgcact cagcgctgtg      480

gggcatttta ctttaggttg cgtattggaa gatcaagagc atcaagtcgc taaagaagaa      540

agggaaacac ctactactga tagtatgccg ccattattac gacaagctat cgaattattt      600

gatcaccaag gtgcagagcc agccttctta ttcggccttg aattgatcat atgcggatta      660

gaaaaacaac ttaaatgtga aagtgggtct taa                                   693


<210> 7
<211> 858
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
cttaaaatat agtcatagaa ttagggcgtc ggttttaaaa gtgtggtaaa ataatggtca       60

agattagtgg taagtaatag gacgtgcttc aggcgtgttg cctgtacgca tgctgattct      120

tcagcaagac tactacctca tgagagttat agactcatgg tataggctcc tatcacatgc      180

tgaacctatg gcctattaca tttttttata tttcaaggag gaaaagacca catgatgtca      240

cgcttggata aatcaaaagt tattaattca gcattggaat tgttgaatga agttggcatt      300

gaaggcttga ccacccgcaa attggcacaa aaattgggcg ttgaacaacc aaccttgtat      360

tggcatgtta aaaataaacg cgcattgttg gatgcattgg caattgaaat gttggatcgc      420

catcataccc atttttgccc attggaaggc gaatcatggc aagatttttt gcgcaataat      480

gcaaaatcat ttcgctgcgc attgttgtca catcgcgatg gcgcaaaagt tcatttgggc      540

acccgcccaa ccgaaaaaca atatgaaacc ttggaaaatc aattggcatt tttgtgccaa      600

caaggctttt cattggaaaa tgcattgtat gcattgtcag cagttggcca ttttaccttg      660

ggctgcgttt tggaagatca agaacatcaa gttgcaaaag aagaacgcga aaccccaacc      720

accgattcaa tgccaccatt gttgcgccaa gcaattgaat tgtttgatca tcaaggcgca      780

gaaccagcat ttttgtttgg cttggaattg attatttgcg gcttggaaaa acaattgaaa      840

tgcgaatcag gctcataa                                                    858


<210> 8
<211> 288
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg tccctatcag tgatagagat      120

caggcgccct atcagtgata gagatgattc ttcagcaaga ctactacctc atgagagtta      180

tagactcatg gatcttgctt tgaagggttt tgtacattat aggctcctat cacatgctga      240

acctatggcc tattacattt ttttatattt caaggaggaa aagaccac                   288


<210> 9
<211> 287
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg ccctatcagt gatagagatc      120

aggctcccta tcagtgatag agatgattct tcagcaagac tactacctca tgagagttat      180

agactcatgg atcttgcttt gaagggtttt gtacattata ggctcctatc acatgctgaa      240

cctatggcct attacatttt tttatatttc aaggaggaaa agaccac                    287


<210> 10
<211> 288
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg tccctatcag tgatagagat      120

caggctccct atcagtgata gagatgattc ttcagcaaga ctactacctc atgagagtta      180

tagactcatg gatcttgctt tgaagggttt tgtacattat aggctcctat cacatgctga      240

acctatggcc tattacattt ttttatattt caaggaggaa aagaccac                   288


<210> 11
<211> 286
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg ccctatcagt gatagagata      120

ggcgccctat cagtgataga gatgattctt cagcaagact actacctcat gagagttata      180

gactcatgga tcttgctttg aagggttttg tacattatag gctcctatca catgctgaac      240

ctatggccta ttacattttt ttatatttca aggaggaaaa gaccac                     286


<210> 12
<211> 286
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg ccctatcagt gatagagatc      120

aggcgcccta tcagtgatag agatattctt cagcaagact actacctcat gagagttata      180

gactcatgga tcttgctttg aagggttttg tacattatag gctcctatca catgctgaac      240

ctatggccta ttacattttt ttatatttca aggaggaaaa gaccac                     286


<210> 13
<211> 285
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg ccctatcagt gatagagata      120

ggcgccctat cagtgataga gatattcttc agcaagacta ctacctcatg agagttatag      180

actcatggat cttgctttga agggttttgt acattatagg ctcctatcac atgctgaacc      240

tatggcctat tacatttttt tatatttcaa ggaggaaaag accac                      285


<210> 14
<211> 287
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg ccctatcagt gatagagatt      120

gacatcccta tcagtgatag agatgattct tcagcaagac tactacctca tgagagttat      180

agactcatgg atcttgcttt gaagggtttt gtacattata ggctcctatc acatgctgaa      240

cctatggcct attacatttt tttatatttc aaggaggaaa agaccac                    287


<210> 15
<211> 287
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg tccctatcag tgatagagat      120

tgacatccct atcagtgata gagatattct tcagcaagac tactacctca tgagagttat      180

agactcatgg atcttgcttt gaagggtttt gtacattata ggctcctatc acatgctgaa      240

cctatggcct attacatttt tttatatttc aaggaggaaa agaccac                    287


<210> 16
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Gly Gly Ser 
1               


<210> 17
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Glu Ala Ala Ala Lys 
1               5   


<210> 18
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Pro Ala Pro Ala Pro 
1               5   


<210> 19
<211> 44
<212> DNA
<213> Escherichia coli 

<400> 19
ataaaacgaa aggctcagtc gaaagactgg gcctttcgtt ttat                        44


<210> 20
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
aaatattaca aatagtattt ttcggtca                                          28


<210> 21
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
tctctaacac tgttaggg                                                     18


<210> 22
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
tctgtatcac tgatacgg                                                     18


<210> 23
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
atcttgcttt gaagggtttt gtacat                                            26


<210> 24
<211> 287
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctaccct atcagtgata gagtacaata ccctatgagt gatagagaag gacgtgcttc      120

aggcgtgttg cctgtacgca tgctgattct tcagcaagac tactacctca tgagagttat      180

agactcatgg atcttgcttt gaagggtttt gtacattata ggctcctatc acatgctgaa      240

cctatggcct attacatttt tttatatttc aaggaggaaa agaccac                    287


<210> 25
<211> 287
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg ccctatcagt gatagagatc      120

aggcgcccta tcagtgatag agatgattct tcagcaagac tactacctca tgagagttat      180

agactcatgg atcttgcttt gaagggtttt gtacattata ggctcctatc acatgctgaa      240

cctatggcct attacatttt tttatatttc aaggaggaaa agaccac                    287


<210> 26
<211> 265
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
ccctatcagt gatagagata tttttcggtc attttaactt gctatttctt gaagaggtta       60

gtacaatatg aatcgtggta agtaatagga cgtgcttcag gcgtgttgcc tgtacgcatg      120

ctgattcttc agcaagacta ctacctcatg agagttatag actcatggat cttgctttga      180

agggttttgt acattatagg ctcctatcac atgctgaacc tatggcctac cctatcagtg      240

atagagacaa ggaggaaaag accac                                            265


<210> 27
<211> 262
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
tgcttgtggg ggtaagcggt aggtgaaata ttacaaatag tatttttcgg tcattttaac       60

ttgctatttc ttgaagaggt tagtacaata tgaatcgtgg taaccctatc agtgatagag      120

attcttcacc ctatcagtga tagagagaga gttatagact catggatctt gctttgaagg      180

gttttgttct ctatcactga tagggacatg cttctctatc actgataggg atttttttat      240

atttcaagga ggaaaagacc ac                                               262


