                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Methods For Modulating Regulatory T Cells And Immune Responses 
       Using CDK4/6 Inhibitors

<130>  DFS-182.25

<140>  PCT/US2018/024818
<141>  2018-03-18

<150>  US 62/478,909
<151>  2017-03-30

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  2020
<212>  DNA
<213>  Homo sapiens

<400>  1
cacctcctgt ccgcccctca gcgcatgggt ggcggtcacg tgcccagaac gtccggcgtt       60

cgccccgccc tcccagtttc cgcgcgcctc tttggcagct ggtcacatgg tgagggtggg      120

ggtgaggggg cctctctagc ttgcggcctg tgtctatggt cgggccctct gcgtccagct      180

gctccggacc gagctcgggt gtatggggcc gtaggaaccg gctccggggc cccgataacg      240

ggccgccccc acagcacccc gggctggcgt gagggtctcc cttgatctga gaatggctac      300

ctctcgatat gagccagtgg ctgaaattgg tgtcggtgcc tatgggacag tgtacaaggc      360

ccgtgatccc cacagtggcc actttgtggc cctcaagagt gtgagagtcc ccaatggagg      420

aggaggtgga ggaggccttc ccatcagcac agttcgtgag gtggctttac tgaggcgact      480

ggaggctttt gagcatccca atgttgtccg gctgatggac gtctgtgcca catcccgaac      540

tgaccgggag atcaaggtaa ccctggtgtt tgagcatgta gaccaggacc taaggacata      600

tctggacaag gcacccccac caggcttgcc agccgaaacg atcaaggatc tgatgcgcca      660

gtttctaaga ggcctagatt tccttcatgc caattgcatc gttcaccgag atctgaagcc      720

agagaacatt ctggtgacaa gtggtggaac agtcaagctg gctgactttg gcctggccag      780

aatctacagc taccagatgg cacttacacc cgtggttgtt acactctggt accgagctcc      840

cgaagttctt ctgcagtcca catatgcaac acctgtggac atgtggagtg ttggctgtat      900

ctttgcagag atgtttcgtc gaaagcctct cttctgtgga aactctgaag ccgaccagtt      960

gggcaaaatc tttgacctga ttgggctgcc tccagaggat gactggcctc gagatgtatc     1020

cctgccccgt ggagcctttc cccccagagg gccccgccca gtgcagtcgg tggtacctga     1080

gatggaggag tcgggagcac agctgctgct ggaaatgctg acttttaacc cacacaagcg     1140

aatctctgcc tttcgagctc tgcagcactc ttatctacat aaggatgaag gtaatccgga     1200

gtgagcaatg gagtggctgc catggaagga agaaaagctg ccatttccct tctggacact     1260

gagagggcaa tctttgcctt tatctctgag gctatggagg gtcctcctcc atctttctac     1320

agagattact ttgctgcctt aatgacattc ccctcccacc tctccttttg aggcttctcc     1380

ttctccttcc catttctcta cactaagggg tatgttccct cttgtccctt tccctacctt     1440

tatatttggg gtcctttttt atacaggaaa aacaaaacaa agaaataatg gtcttttttt     1500

tttttttaat gtttcttcct ctgtttggct ttgccattgt gcgatttgga aaaaccactt     1560

ggaagaaggg actttcctgc aaaaccttaa agactggtta aattacaggg cctaggaagt     1620

cagtggagcc ccttgactga caaagcttag aaaggaactg aaattgcttc tttgaatatg     1680

gattttaggc ggggcgtggt ggctcacgcc tataatccca gcacgttggg aggccaacgc     1740

gggtggatca cctgaggtca ggagttcgag accagcctga ctaacatggt gaaaccctgt     1800

ctctactaaa aatacaaaat tagtcaggcg tggtggtgca cacctgtaat cccagctact     1860

tgggagactg aggcaggagg atcgcttgaa cccgggaggc agaggttgcg gtgagccgag     1920

atcatgccat tgcactccag cctgggcaac agagcaagac tctgtgtcaa aaaaaaaaaa     1980

agaatataga tttttaaatg gcaaaaaaaa aaaaaaaaaa                           2020


<210>  2
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210>  3
<211>  1365
<212>  DNA
<213>  Mus musculus

<400>  3
gtgggggtga gggggcctct ctagctcgcg gcctgtgtct atggtctggc ccgaagcgtc       60

cagctgcccg ggaccgatcc ccggtgtatg gcgccgcagg aaccggctcc cgggcccaga      120

taaagggcca cctccagagc tcttagccga gcgtaagatc ccctgcttcg agaatggctg      180

ccactcgata tgaacccgtg gctgaaattg gtgtcggtgc ctatgggacg gtgtacaaag      240

cccgagatcc ccacagtggc cactttgtgg ccctcaagag tgtgagagtt cctaatggag      300

gagcagctgg agggggcctt cccgtcagca cagttcgtga ggtggccttg ttaaggaggc      360

tggaggcctt tgaacatccc aatgttgtac ggctgatgga tgtctgtgct acttcccgaa      420

ctgatcggga catcaaggtc accctagtgt ttgagcatat agaccaggac ctgaggacat      480

acctggacaa agcacctcca ccgggcctgc cggttgagac cattaaggat ctaatgcgtc      540

agtttctaag cggcctggat tttcttcatg caaactgcat tgttcaccgg gacctgaagc      600

cagagaacat tctagtgaca agtaatggga ccgtcaagct ggctgacttt ggcctagcta      660

gaatctacag ctaccagatg gccctcacgc ctgtggtggt tacgctctgg taccgagctc      720

ctgaagttct tctgcagtct acatacgcaa cacccgtgga catgtggagc gttggctgta      780

tctttgcaga gatgttccgt cggaagcctc tcttctgtgg aaactctgaa gccgaccagt      840

tggggaaaat ctttgatctc attggattgc ctccagaaga cgactggcct cgagaggtat      900

ctctacctcg aggagccttt gcccccagag ggcctcggcc agtgcagtca gtggtgccag      960

agatggagga gtctggagcg cagctgctac tggaaatgct gacctttaac ccacataagc     1020

gaatctctgc cttccgagcc ctgcagcact cctacctgca caaggaggaa agcgacgcag     1080

agtgagaaga ggggctgcct ttcccagtct tggtggagaa accctcgctg aagcggcagc     1140

ctctgtttcc ccccaaggct gtggagaatc ctccagtttt ttacagagaa tattttaagc     1200

cttaaataac aagtccccac ctctccttac gaggttcacc cccattaccc tcccctagct     1260

ctacactaaa gggcaggtgt atctgtcttc ttccctccct gatttatact gggatctttt     1320

ttatacagga aaacaagaca agacaaaaaa aaaaaaaaaa aaaaa                     1365


<210>  4
<211>  303
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Ala Thr Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Ala Ala Gly Gly Gly 
        35                  40                  45              


Leu Pro Val Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Asp Ile Lys Val Thr Leu Val Phe Glu His Ile 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Val Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Ser Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Asn Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Glu Val Ser Leu Pro Arg Gly Ala Phe Ala Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Glu Glu Ser Asp Ala Glu 
    290                 295                 300             


<210>  5
<211>  11628
<212>  DNA
<213>  Homo sapiens

<400>  5
aacctctccg cgcgaagacg gcttcagccc tgcagggaaa gaaaagtgca atgattctgg       60

actgagacgc gcttgggcag aggctatgta atcgtgtctg tgttgaggac ttcgcttcga      120

ggagggaaga ggagggatcg gctcgctcct ccggcggcgg cggcggcggc gactctgcag      180

gcggagtttc gcggcggcgg caccagggtt acgccagccc cgcggggagg tctctccatc      240

cagcttctgc agcggcgaaa gccccagcgc ccgagcgcct gagccggcgg ggagcaagta      300

aagctagacc gatctccggg gagccccgga gtaggcgagc ggcggccgcc agctagttga      360

gcgcaccccc cgcccgcccc agcggcgccg cggcgggcgg cgtccaggcg gcatggagaa      420

ggacggcctg tgccgcgctg accagcagta cgaatgcgtg gcggagatcg gggagggcgc      480

ctatgggaag gtgttcaagg cccgcgactt gaagaacgga ggccgtttcg tggcgttgaa      540

gcgcgtgcgg gtgcagaccg gcgaggaggg catgccgctc tccaccatcc gcgaggtggc      600

ggtgctgagg cacctggaga ccttcgagca ccccaacgtg gtcaggttgt ttgatgtgtg      660

cacagtgtca cgaacagaca gagaaaccaa actaacttta gtgtttgaac atgtcgatca      720

agacttgacc acttacttgg ataaagttcc agagcctgga gtgcccactg aaaccataaa      780

ggatatgatg tttcagcttc tccgaggtct ggactttctt cattcacacc gagtagtgca      840

tcgcgatcta aaaccacaga acattctggt gaccagcagc ggacaaataa aactcgctga      900

cttcggcctt gcccgcatct atagtttcca gatggctcta acctcagtgg tcgtcacgct      960

gtggtacaga gcacccgaag tcttgctcca gtccagctac gccacccccg tggatctctg     1020

gagtgttggc tgcatatttg cagaaatgtt tcgtagaaag cctctttttc gtggaagttc     1080

agatgttgat caactaggaa aaatcttgga cgtgattgga ctcccaggag aagaagactg     1140

gcctagagat gttgcccttc ccaggcaggc ttttcattca aaatctgccc aaccaattga     1200

gaagtttgta acagatatcg atgaactagg caaagaccta cttctgaagt gtttgacatt     1260

taacccagcc aaaagaatat ctgcctacag tgccctgtct cacccatact tccaggacct     1320

ggaaaggtgc aaagaaaacc tggattccca cctgccgccc agccagaaca cctcggagct     1380

gaatacagcc tgaggcctca gcagccgcct taagctgatc ctgcggagaa cacccttggt     1440

ggcttatggg tccccctcag caagccctac agagctgtgg aggattgcta tctggaggcc     1500

ttccagctgc tgtcttctgg acaggctctg cttctccaag gaaaccgcct agtttactgt     1560

tttgaaatca atgcaagagt gattgcagct ttatgttcat ttgtttgttt gtttgtctgt     1620

ttgtttcaag aacctggaaa aattccagaa gaagagaagc tgctgaccaa ttgtgctgcc     1680

atttgatttt tctaaccttg aatgctgcca gtgtggagtg ggtaatccag gcacagctga     1740

gttatgatgt aatctctctg cagctgccgg gcctgatttg gtacttttga gtgtgtgtgt     1800

gcatgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtatgt gagagattct gtgatctttt     1860

aaagtgttac tttttgtaaa cgacaagaat aattcaattt taaagactca aggtggtcag     1920

taaataacag gcatttgttc actgaaggtg attcaccaaa atagtcttct caaattagaa     1980

agttaacccc atgtcctcag catttctttt ctggccaaaa gcagtaaatt tgctagcagt     2040

aaaagatgaa gttttataca cacagcaaaa aggagaaaaa attctagtat attttaagag     2100

atgtgcatgc attctattta gtcttcagaa tgctgaattt acttgttgta agtctatttt     2160

aaccttctgt atgacatcat gctttatcat ttcttttgga aaatagcctg taagcttttt     2220

attacttgct ataggtttag ggagtgtacc tcagatagat tttaaaaaaa agaatagaaa     2280

gcctttattt cctggtttga aattcctttc ttcccttttt ttgttgttgt tattgttgtt     2340

tgttgttgtt attttgtttt tgtttttagg aatttgtcag aaactctttc ctgttttggt     2400

ttggagagta gttctctcta actagagaca ggagtggcct tgaaattttc ctcatctatt     2460

acactgtact ttctgccaca cactgccttg ttggcaaagt atccatcttg tctatctccc     2520

ggcacttctg aaatatattg ctaccattgt ataactaata acagattgct taagctgttc     2580

ccatgcacca cctgtttgct tgctttcaat gaacctttca taaattcgca gtctcagctt     2640

atggtttatg gcctcgattc tgcaaaccta acagggtcac atatgttctc taatgcagtc     2700

cttctacctg gtgtttactt ttgttaccta aataatgagt aggatcttgt tttgttttat     2760

caccagcaca cagattgcta taaactgtta ctttgtgaat tacattttta tagaagatat     2820

tttcagtgtc tttacctgag ggtatgtctt tagctatgtt ttagggccat acatttactc     2880

tatcaaatga tcttttctcc atcccccagg ctgtgcttat ttctagtgcc ttgtgctcac     2940

tcctgctctc tacagagcca gcctggcctg ggcattgtaa acagcttttc ctttttctct     3000

tactgttttc tctacagtcc tttatatttc ataccatctc tgccttataa gtggtttagt     3060

gctcagttgg ctctagtaac cagaggacac agaaagtatc ttttggaaag tttagccacc     3120

tgtgctttct gactcagagt gcatgcaaca gttagatcat gcaacagtta gattatgttt     3180

agggttagga ttttcaaaga atggaggttg ctgcactcag aaaataattc agatcatgtt     3240

tatgcattat taagttgtac tgaattcttt gcagcttaat gtgatatatg actatcttga     3300

acaagagaaa aaactaggag atgtttctcc tgaagagctt ttggggttgg gaactattct     3360

tttttaattg ctgtactact taacattgtt ctaattcagt agcttgagga acaggaacat     3420

tgttttctag agcaagataa taaaggagat gggccataca aatgttttct actttcgttg     3480

tgacaacatt gattaggtgt tgtcagtact ataaatgctt gagatataat gaatccacag     3540

cattcaaggt caggtctact caaagtctca catggaaaag tgagttctgc ctttcctttg     3600

atcgagggtc aaaatacaaa gacatttttg ctagggccta caaattgaat ttaaaaactc     3660

actgcactga ttcatctgag ctttttggtt agtattcatg gctagagtga acatagcttt     3720

agtttttgct gttgtaaaag tgttttcata agttcactca agaaaaatgc agctgttctg     3780

aactggaatt tttcagcatt ctttagaatt ttaaatgagt agagagctca acttttattc     3840

ctagcatctg cttttgactc atttctaggc agtgcttatg aagaaaaatt aaagcacaaa     3900

cattctggca ttcaatcgtt ggcagattat cttctgatga cacagaatga aagggcatct     3960

cagcctctct gaactttgta aaaatctgtc cccagttctt ccatcggtgt agttgttgca     4020

tttgagtgaa tactctcttg atttatgtat tttatgtcca gattcgccat ttctgaaatc     4080

cagatccaac acaagcagtc ttgccgttag ggcattttga agcagatagt agagtaagaa     4140

cttagtgact acagcttatt cttctgtaac atatggtttc aaacatcttt gccaaaagct     4200

aagcagtggt gaactgaaaa gggcatattg ccccaaggtt acactgaagc agctcatagc     4260

aagttaaaat attgtgacag atttgaaatc atgtttgaat ttcatagtag gaccagtaca     4320

agaatgtccc tgctagtttc tgtttgatgt ttggttctgg cggctcaggc attttgggaa     4380

ctgttgcaca gggtggagtc aaaacaacct acatataaaa agagaaaaag agaaacttgt     4440

ccatttagct ttcataagaa atcccatggc aaagggtaat aaaaaggacc taatcttaaa     4500

aatacaattt ctaagcactt gtaagaaccc agtgggttgg agcctcccac tttgtccctc     4560

ctttgaagtg gatgggaact caaggtgcaa agaacctgtt ttggaagaaa gcttggggcc     4620

atttcagccc cctgtattct catgattttc tctcaggaag cacacactgt gaatggcaga     4680

cttttcattt agccccaggt gacttactaa aaatagttga aaattattca cctaagaata     4740

gaatctcagc attgtgttaa ataaaaatga aagctttaga aggcatgaga tgttcctatc     4800

ttaaataaag catgtttctt ttctatagag aaatgtatag tttgactctc cagaatgtac     4860

tatccatctt gatgagaaaa ctcttaaata gtaccaaaca ttttgaactt taaattatgt     4920

atttaaagtg agtgtttaag aaactgtagc tgcttctttt acaagtggtg cctattaaag     4980

tcagtaatgg ccattattgt tccattgtgg aaattaaatt atgtaagctt cctaatatca     5040

taaacatatt aaaattcttc taaaatattg cttttctttt aagtgacaat ttgactattc     5100

ttatgataag cacatgagag tgtcttacat tttccaaaag caggctttaa ttgcatagtt     5160

gagtctagga aaaaataatg ttaaaagtga atatgccacc ataattactt aattatgtta     5220

gtatagaaac tacagaatat ttaccctgga aagaaaatat tggaatgtta ttataaactc     5280

ttagatattt atataattca aaagaatgca tgtttcacat tgtgacagat aaagatgtat     5340

gatttctaag gctttaaaaa ttattcataa aacagtgggc aatagataaa ggaaattctg     5400

gagaaaatga aggtatttaa agggtagttt caaagctata tatattttga aggatatatt     5460

ctttatgaac aaatatattg taaaaattta tactaaggtc atctggtaac tgtgggatta     5520

atatggtcga aaacaaatgt tatggagaag ctgtcccaag caaactaaat tacctgtact     5580

tttttcccat ttcaagggaa gaggcaacca catgaagcaa tacttcttac acatgcctaa     5640

gaacgttcat tgaaaaaata aatttttaaa aggcatgtgt ttcctatgcc accaatactt     5700

ttgaaaaatt gtgaacctta cccaaaacca tttatcatgt ccattaagta tatttgggta     5760

tataattagg aagatattta catgttccat ctccacagtg gaaaaactta ttgaggctac     5820

caaagtgtgc caagaaatgt aagtccttag agtaattaga aatgctgttt tcctcaaaag     5880

catgagaaac tagcattttc atttcttatt tactcccttt ctatatcaat gcaattcaca     5940

acccaatttt aatacatccc tatatctcaa gcatttctat cttgtacttt ttcagaaaat     6000

aaaccaaaaa taatcctttg gtctctctat cttctgacct ttgtaagcaa cagaaatgta     6060

aaaacagaag gggtccaatt tttacacgtt tttttctcaa gtagcctttc tggggatttt     6120

tattttctta atgaagtgcc aatcagcttt tcaaaatgtt ttctatttct cagcatttcc     6180

aggaagtgat aacgtttagc taaatgagta gaagtggact tccttcaaca tattgttacc     6240

ttgtctagcc ttaggaagaa aacaagagcc acctgaaaat aaatacaggc tcttttcgag     6300

catctgctga aatactgtta cagcaatttg aagttgatgt ggtaggaaag gaaggtgact     6360

tttcttgcaa aagtctttct aaacattcac actgtcctaa gagatgagct ttcttgtttt     6420

attccggtat attccacaag gtggcacttt tagagaaaaa caaatctgat gaagactaaa     6480

gaggtacttc taaaagagat ttcattctaa ctttattttt ctgcgcatat ttaactcttt     6540

cctagcactt gttttttggg atgattaata gtctctataa tgttctgtaa cttcaatatt     6600

ttacttgtta cctaggttct gaacaattgt ctgcaaataa attgttctta aggatggata     6660

atacacccat tttgatcatt taagtaaaga aagcctagtc attcattcag tcaagaaaaa     6720

atttttgaag tacccagtta ccttactttt ctagattaaa acaggcttag ttactaaaaa     6780

ggcagtcctc atctgtgaac aggatagttt cgttagaagt ataaaactcc tttagtggcc     6840

ccagttaaaa cacacatacc ctctctgctg ctttcaaatt ccctagcatg gtggcctttc     6900

aacattgatt aaattttaaa atcctaattt aaagatcagg tgagcaaaat gagtagcaca     6960

tcagtaattc agtagacaaa acttttgtct gaaaaattgc tgtattgaaa cagagcccta     7020

aaataccaaa agaccaggta attttaacat ttgtggaatc acaaatgtaa attcataaga     7080

agctctaatt aaaaaaaaaa agtctgaagt atatgagcat aacaacttag gagtgtgtct     7140

acatacttaa cttttgaagt tttttggcaa ctttatatac tttttttaaa tttacaagtc     7200

tacttaaaga cttcttatac cccaaatgat taagttaatt ttagaggtca cctttctcac     7260

agcagtgtca cttgaaattt agtagggaag gatattgcag tatttttcag tttccttagc     7320

acagcaccac agaaagcagc ttattccttt tgagtggcag acactcgacg gtgcctgccc     7380

aactttcctc ctgagtggca agcagatgag tctcagtaat tcatactgaa ccaaaatgcc     7440

acatacacta ggggcagtca gaaactggct gagaaatccc ccgcctcatt cgcccctctg     7500

ctcccaggaa ctagagtcca gttaaagccc ctatgcgaaa ggccgaattc caccccaggg     7560

tttgttataa cagtggccag tctgaacccc atttgctcgt gctcaaaact tgattcccac     7620

ttgaaagcct tccgggcgcg ctgcctcgtt gccccgcccc tttggcagga gagaggcagt     7680

gggcgaggcc gggctggggc cccgcctccc actcacctgc cggtgcctga aattatgtgc     7740

ggccccgcgg gctgctttcc gaggtcagag tgccctgctg ctgtctcaga ggcatctgtt     7800

ctgcaaatct taggaagaaa aatgtcccta gtagcaaacg ggtgtcttct gtgcataaat     7860

aagtacaaca caattctccg aaagttcggg taaaaagaga tgcggtagca gctgccctgt     7920

gtgaagctgt ctaccccgca tctctcaggc gctaagctca gtttttgttt ttgtttttgt     7980

ttttttaaag aaaagatgta taattgcagg aatttttttt tattttttta ttttccatca     8040

ttctatatat gtgatggtga aagatatgcc tggaaaagtt ttgttttgaa aagtttattt     8100

tctgcttcgt cttcagttgg caaaagctct caattcttta gcttccagtt tcttttctct     8160

ctttttcttt gttaggtaat taaaggtatg taaacaaatt atctcatgta gcaggggatt     8220

ttcatgttga gaggaatctt ccgtgtgagt tgtttggtca cacaaataac cctttctcaa     8280

ttttaggagt ttggattgtc aaatgtaggt ttttctcaaa gggggcatat aactacatat     8340

tgactgccaa gaactatgac tgtagcacta atcagcacac atagagccac acaattattt     8400

aatttctaac tctctgtggt ccctagaaaa attccgttga tgtgcttagg ttaaagttct     8460

gaagataccc gttgtaccct tacttgaaag tttctaatct taagttttat gaaatgcaat     8520

aatatgtatc agctagcaat atttctgtga tcaccaacaa ctctcagttt gatcttaaag     8580

tctgaataat aaaacaaatc ccagcagtaa tacatttctt aaacctcaca gtgcatgata     8640

tatcttttca ttctgatcct gtgtttgcaa aaatatacac atgtatatca tagttcctca     8700

ctttttattc atttgttttc ctattacctg tagtaaatat attagttagt acatggaatt     8760

tatagcatca gctaccccca ggaacagcac ctgacaggcg ggggattttt tttcaagttg     8820

ttctacattt gcataaatta tttctattat tattcatgta tgttatttat ttctgaatca     8880

cactagtcct gtgaaagtac aactgaaggc agaaagtgtt aggattttgc atctaatgtt     8940

cattatcatg gtattgatgg acctaagaaa ataaaaatta gactaagccc ccaaataagc     9000

tgcatgcatt tgtaacatga ttagtagatt tgaatatata gatgtagtat tttgggtatc     9060

taggtgtttt atcattatgt aaaggaatta aagtaaagga ctttgtagtt gtttttatta     9120

aatatgcata tagtagagtg caaaaatata gcaaaaataa aaactaaagg tagaaaagca     9180

ttttagatat gccttaattt agaaactgtg ccaggtggcc ctcggaatag atgccaggca     9240

gagaccagtg cctgggtggt gcctcctctt gtctgccctc atgaagaagc ttccctcacg     9300

tgatgtagtg ccctcgtagg tgtcatgtgg agtagtggga acaggcagta ctgttgagag     9360

gagagcagtg tgagagtttt tctgtagaag cagaactgtc agcttgtgcc ttgaggcttc     9420

cagaacgtgt cagatggaga agtccaagtt tccatgcttc aggcaactta gctgtgtaca     9480

gaagcaatcc agtgtggtaa taaaaagcaa ggattgcctg tataatttat tataaaataa     9540

aagggatttt aacaaccaac aattcccaac acctcaaaag cttgttgcat tttttggtat     9600

ttgaggtttt tatctgaagg ttaaagggca agtgtttggt atagaagagc agtatgtgtt     9660

aagaaaagaa aaatattggt tcacgtagag tgcaaattag aactagaaag ttttatacga     9720

ttatcatttt gagatgtgtt aaagtaggtt ttcactgtaa aatgtattag tgtttctgca     9780

ttgccatagg gcctggttaa aactttctct taggtttcag gaagactgtc acatacagta     9840

agcttttttc cttctgactt ataatagaaa atgttttgaa agtaaaaaaa aaaaatctaa     9900

tttggaaatt tgacttgtta gtttctgtgt ttgaaatcat ggttctagaa atgtagaaat     9960

tgtgtatatc agatactcat ctaggctgtg tgaaccagcc caagatgacc aacatcccca    10020

cacctctaca tctctgtccc ctgtatctct tcctttctac cactaaagtg ttccctgcta    10080

ccatcctggc ttgtccacat ggtgctctcc atcttcctcc acatcatgga ccacaggtgt    10140

gcctgtctag gcctggccac cactcccaac ttgacctagc cacattcatc tagagatggt    10200

tcctgatgct gggcacagac tgtgctcatg gcacccatta gaaatgcctc tagcatcttt    10260

gtatgcatct tgatttttaa accaagtcat tgtacagagc attcagtttt ggctgtggta    10320

ccaagagaaa aactaatcaa gaatataaac cacattccag gctgctgttt tctctccatc    10380

tacaggccac acttttactg tatttcttca tacttgaaat tcattctgct attttcatat    10440

cagggtacag acttataagg gtgcatgttc cttaaaggtg cataattatt cttattccgt    10500

ttgcttatat tgctacagaa tgctctgttt tggtgctttg agttctgcag acccaagaag    10560

cagtgtggaa attcactgcc tgggacacag tcttataaga atgttggcag gtgactttgt    10620

atcagatgtt gcttctcttt tctctgtaca cagattgaga gttaccacag tggcctgtcg    10680

ggtccaccct gtgggtgcag cacagctctc tgaaagcaag aaccttccta cctattctaa    10740

cgtttttgcc ctctaagaaa aatggcctca ggtatggtat agacatagca agaggggaag    10800

ggctgtctca ctctagcaac catccctcca ttacacacag aaagccctct tgaagcaaaa    10860

gaagaagaaa gaaagaaagc ttatctctaa ggctactgtc ttcagaatgc tctgagctga    10920

atgctcttgc tcctttccca agaggcagat gaaaatatag ccagtttatc tatacccttc    10980

ctatctgagg aggagaatag aaaagtaggg taaatatgta acgtaaaata tgtcattcaa    11040

ggaccaccaa aactttaagt accctatcat taaaaatctg gttttaaaag tagctcaagt    11100

aagggatgct ttgtgaccca gggtttctga agtcagatag ccattcttac ctgcccctta    11160

ctctgactta ttgggaaagg gagaactgca gtggtgtttc tgttgcagtg gcaaaggtaa    11220

catgtcagaa aattcagagg gttgcatacc aataatcctt tggaaactgg atgtcttact    11280

gggtgctaga atgaaaatgt aggtatttat tgtcagatga tgaagttcat tgtttttttc    11340

aaaattggtg ttgaaatatc actgtccaat gtgttcactt atgtgaaagc taaattgaat    11400

gaggcaaaaa gagcaaatag tttgtatatt tgtaatacct tttgtatttc ttacaataaa    11460

aatattggta gcaaataaaa ataataaaaa caataacttt aaactgcttt ctggagatga    11520

attactctcc tggctatttt cttttttact ttaatgtaaa atgagtataa ctgtagtgag    11580

taaaattcat taaattccaa gttttagcag aaaaaaaaaa aaaaaaaa                 11628


<210>  6
<211>  11733
<212>  DNA
<213>  Homo sapiens

<400>  6
cgccgctgtg cccaccccct cgccggagag agtgctggta actccttccc cagagtctga       60

ttacctgctc cgcgaggccg cggacacgtg cggagagccg actgacactc gcagccccct      120

cgggaggccc gacgcgactg ggcccctcag gtgcaatgat tctggactga gacgcgcttg      180

ggcagaggct atgtaatcgt gtctgtgttg aggacttcgc ttcgaggagg gaagaggagg      240

gatcggctcg ctcctccggc ggcggcggcg gcggcgactc tgcaggcgga gtttcgcggc      300

ggcggcacca gggttacgcc agccccgcgg ggaggtctct ccatccagct tctgcagcgg      360

cgaaagcccc agcgcccgag cgcctgagcc ggcggggagc aagtaaagct agaccgatct      420

ccggggagcc ccggagtagg cgagcggcgg ccgccagcta gttgagcgca ccccccgccc      480

gccccagcgg cgccgcggcg ggcggcgtcc aggcggcatg gagaaggacg gcctgtgccg      540

cgctgaccag cagtacgaat gcgtggcgga gatcggggag ggcgcctatg ggaaggtgtt      600

caaggcccgc gacttgaaga acggaggccg tttcgtggcg ttgaagcgcg tgcgggtgca      660

gaccggcgag gagggcatgc cgctctccac catccgcgag gtggcggtgc tgaggcacct      720

ggagaccttc gagcacccca acgtggtcag gttgtttgat gtgtgcacag tgtcacgaac      780

agacagagaa accaaactaa ctttagtgtt tgaacatgtc gatcaagact tgaccactta      840

cttggataaa gttccagagc ctggagtgcc cactgaaacc ataaaggata tgatgtttca      900

gcttctccga ggtctggact ttcttcattc acaccgagta gtgcatcgcg atctaaaacc      960

acagaacatt ctggtgacca gcagcggaca aataaaactc gctgacttcg gccttgcccg     1020

catctatagt ttccagatgg ctctaacctc agtggtcgtc acgctgtggt acagagcacc     1080

cgaagtcttg ctccagtcca gctacgccac ccccgtggat ctctggagtg ttggctgcat     1140

atttgcagaa atgtttcgta gaaagcctct ttttcgtgga agttcagatg ttgatcaact     1200

aggaaaaatc ttggacgtga ttggactccc aggagaagaa gactggccta gagatgttgc     1260

ccttcccagg caggcttttc attcaaaatc tgcccaacca attgagaagt ttgtaacaga     1320

tatcgatgaa ctaggcaaag acctacttct gaagtgtttg acatttaacc cagccaaaag     1380

aatatctgcc tacagtgccc tgtctcaccc atacttccag gacctggaaa ggtgcaaaga     1440

aaacctggat tcccacctgc cgcccagcca gaacacctcg gagctgaata cagcctgagg     1500

cctcagcagc cgccttaagc tgatcctgcg gagaacaccc ttggtggctt atgggtcccc     1560

ctcagcaagc cctacagagc tgtggaggat tgctatctgg aggccttcca gctgctgtct     1620

tctggacagg ctctgcttct ccaaggaaac cgcctagttt actgttttga aatcaatgca     1680

agagtgattg cagctttatg ttcatttgtt tgtttgtttg tctgtttgtt tcaagaacct     1740

ggaaaaattc cagaagaaga gaagctgctg accaattgtg ctgccatttg atttttctaa     1800

ccttgaatgc tgccagtgtg gagtgggtaa tccaggcaca gctgagttat gatgtaatct     1860

ctctgcagct gccgggcctg atttggtact tttgagtgtg tgtgtgcatg tgtgtgtgtg     1920

tgtgtgtgtg tgtgtgtgtg tatgtgagag attctgtgat cttttaaagt gttacttttt     1980

gtaaacgaca agaataattc aattttaaag actcaaggtg gtcagtaaat aacaggcatt     2040

tgttcactga aggtgattca ccaaaatagt cttctcaaat tagaaagtta accccatgtc     2100

ctcagcattt cttttctggc caaaagcagt aaatttgcta gcagtaaaag atgaagtttt     2160

atacacacag caaaaaggag aaaaaattct agtatatttt aagagatgtg catgcattct     2220

atttagtctt cagaatgctg aatttacttg ttgtaagtct attttaacct tctgtatgac     2280

atcatgcttt atcatttctt ttggaaaata gcctgtaagc tttttattac ttgctatagg     2340

tttagggagt gtacctcaga tagattttaa aaaaaagaat agaaagcctt tatttcctgg     2400

tttgaaattc ctttcttccc tttttttgtt gttgttattg ttgtttgttg ttgttatttt     2460

gtttttgttt ttaggaattt gtcagaaact ctttcctgtt ttggtttgga gagtagttct     2520

ctctaactag agacaggagt ggccttgaaa ttttcctcat ctattacact gtactttctg     2580

ccacacactg ccttgttggc aaagtatcca tcttgtctat ctcccggcac ttctgaaata     2640

tattgctacc attgtataac taataacaga ttgcttaagc tgttcccatg caccacctgt     2700

ttgcttgctt tcaatgaacc tttcataaat tcgcagtctc agcttatggt ttatggcctc     2760

gattctgcaa acctaacagg gtcacatatg ttctctaatg cagtccttct acctggtgtt     2820

tacttttgtt acctaaataa tgagtaggat cttgttttgt tttatcacca gcacacagat     2880

tgctataaac tgttactttg tgaattacat ttttatagaa gatattttca gtgtctttac     2940

ctgagggtat gtctttagct atgttttagg gccatacatt tactctatca aatgatcttt     3000

tctccatccc ccaggctgtg cttatttcta gtgccttgtg ctcactcctg ctctctacag     3060

agccagcctg gcctgggcat tgtaaacagc ttttcctttt tctcttactg ttttctctac     3120

agtcctttat atttcatacc atctctgcct tataagtggt ttagtgctca gttggctcta     3180

gtaaccagag gacacagaaa gtatcttttg gaaagtttag ccacctgtgc tttctgactc     3240

agagtgcatg caacagttag atcatgcaac agttagatta tgtttagggt taggattttc     3300

aaagaatgga ggttgctgca ctcagaaaat aattcagatc atgtttatgc attattaagt     3360

tgtactgaat tctttgcagc ttaatgtgat atatgactat cttgaacaag agaaaaaact     3420

aggagatgtt tctcctgaag agcttttggg gttgggaact attctttttt aattgctgta     3480

ctacttaaca ttgttctaat tcagtagctt gaggaacagg aacattgttt tctagagcaa     3540

gataataaag gagatgggcc atacaaatgt tttctacttt cgttgtgaca acattgatta     3600

ggtgttgtca gtactataaa tgcttgagat ataatgaatc cacagcattc aaggtcaggt     3660

ctactcaaag tctcacatgg aaaagtgagt tctgcctttc ctttgatcga gggtcaaaat     3720

acaaagacat ttttgctagg gcctacaaat tgaatttaaa aactcactgc actgattcat     3780

ctgagctttt tggttagtat tcatggctag agtgaacata gctttagttt ttgctgttgt     3840

aaaagtgttt tcataagttc actcaagaaa aatgcagctg ttctgaactg gaatttttca     3900

gcattcttta gaattttaaa tgagtagaga gctcaacttt tattcctagc atctgctttt     3960

gactcatttc taggcagtgc ttatgaagaa aaattaaagc acaaacattc tggcattcaa     4020

tcgttggcag attatcttct gatgacacag aatgaaaggg catctcagcc tctctgaact     4080

ttgtaaaaat ctgtccccag ttcttccatc ggtgtagttg ttgcatttga gtgaatactc     4140

tcttgattta tgtattttat gtccagattc gccatttctg aaatccagat ccaacacaag     4200

cagtcttgcc gttagggcat tttgaagcag atagtagagt aagaacttag tgactacagc     4260

ttattcttct gtaacatatg gtttcaaaca tctttgccaa aagctaagca gtggtgaact     4320

gaaaagggca tattgcccca aggttacact gaagcagctc atagcaagtt aaaatattgt     4380

gacagatttg aaatcatgtt tgaatttcat agtaggacca gtacaagaat gtccctgcta     4440

gtttctgttt gatgtttggt tctggcggct caggcatttt gggaactgtt gcacagggtg     4500

gagtcaaaac aacctacata taaaaagaga aaaagagaaa cttgtccatt tagctttcat     4560

aagaaatccc atggcaaagg gtaataaaaa ggacctaatc ttaaaaatac aatttctaag     4620

cacttgtaag aacccagtgg gttggagcct cccactttgt ccctcctttg aagtggatgg     4680

gaactcaagg tgcaaagaac ctgttttgga agaaagcttg gggccatttc agccccctgt     4740

attctcatga ttttctctca ggaagcacac actgtgaatg gcagactttt catttagccc     4800

caggtgactt actaaaaata gttgaaaatt attcacctaa gaatagaatc tcagcattgt     4860

gttaaataaa aatgaaagct ttagaaggca tgagatgttc ctatcttaaa taaagcatgt     4920

ttcttttcta tagagaaatg tatagtttga ctctccagaa tgtactatcc atcttgatga     4980

gaaaactctt aaatagtacc aaacattttg aactttaaat tatgtattta aagtgagtgt     5040

ttaagaaact gtagctgctt cttttacaag tggtgcctat taaagtcagt aatggccatt     5100

attgttccat tgtggaaatt aaattatgta agcttcctaa tatcataaac atattaaaat     5160

tcttctaaaa tattgctttt cttttaagtg acaatttgac tattcttatg ataagcacat     5220

gagagtgtct tacattttcc aaaagcaggc tttaattgca tagttgagtc taggaaaaaa     5280

taatgttaaa agtgaatatg ccaccataat tacttaatta tgttagtata gaaactacag     5340

aatatttacc ctggaaagaa aatattggaa tgttattata aactcttaga tatttatata     5400

attcaaaaga atgcatgttt cacattgtga cagataaaga tgtatgattt ctaaggcttt     5460

aaaaattatt cataaaacag tgggcaatag ataaaggaaa ttctggagaa aatgaaggta     5520

tttaaagggt agtttcaaag ctatatatat tttgaaggat atattcttta tgaacaaata     5580

tattgtaaaa atttatacta aggtcatctg gtaactgtgg gattaatatg gtcgaaaaca     5640

aatgttatgg agaagctgtc ccaagcaaac taaattacct gtactttttt cccatttcaa     5700

gggaagaggc aaccacatga agcaatactt cttacacatg cctaagaacg ttcattgaaa     5760

aaataaattt ttaaaaggca tgtgtttcct atgccaccaa tacttttgaa aaattgtgaa     5820

ccttacccaa aaccatttat catgtccatt aagtatattt gggtatataa ttaggaagat     5880

atttacatgt tccatctcca cagtggaaaa acttattgag gctaccaaag tgtgccaaga     5940

aatgtaagtc cttagagtaa ttagaaatgc tgttttcctc aaaagcatga gaaactagca     6000

ttttcatttc ttatttactc cctttctata tcaatgcaat tcacaaccca attttaatac     6060

atccctatat ctcaagcatt tctatcttgt actttttcag aaaataaacc aaaaataatc     6120

ctttggtctc tctatcttct gacctttgta agcaacagaa atgtaaaaac agaaggggtc     6180

caatttttac acgttttttt ctcaagtagc ctttctgggg atttttattt tcttaatgaa     6240

gtgccaatca gcttttcaaa atgttttcta tttctcagca tttccaggaa gtgataacgt     6300

ttagctaaat gagtagaagt ggacttcctt caacatattg ttaccttgtc tagccttagg     6360

aagaaaacaa gagccacctg aaaataaata caggctcttt tcgagcatct gctgaaatac     6420

tgttacagca atttgaagtt gatgtggtag gaaaggaagg tgacttttct tgcaaaagtc     6480

tttctaaaca ttcacactgt cctaagagat gagctttctt gttttattcc ggtatattcc     6540

acaaggtggc acttttagag aaaaacaaat ctgatgaaga ctaaagaggt acttctaaaa     6600

gagatttcat tctaacttta tttttctgcg catatttaac tctttcctag cacttgtttt     6660

ttgggatgat taatagtctc tataatgttc tgtaacttca atattttact tgttacctag     6720

gttctgaaca attgtctgca aataaattgt tcttaaggat ggataataca cccattttga     6780

tcatttaagt aaagaaagcc tagtcattca ttcagtcaag aaaaaatttt tgaagtaccc     6840

agttacctta cttttctaga ttaaaacagg cttagttact aaaaaggcag tcctcatctg     6900

tgaacaggat agtttcgtta gaagtataaa actcctttag tggccccagt taaaacacac     6960

ataccctctc tgctgctttc aaattcccta gcatggtggc ctttcaacat tgattaaatt     7020

ttaaaatcct aatttaaaga tcaggtgagc aaaatgagta gcacatcagt aattcagtag     7080

acaaaacttt tgtctgaaaa attgctgtat tgaaacagag ccctaaaata ccaaaagacc     7140

aggtaatttt aacatttgtg gaatcacaaa tgtaaattca taagaagctc taattaaaaa     7200

aaaaaagtct gaagtatatg agcataacaa cttaggagtg tgtctacata cttaactttt     7260

gaagtttttt ggcaacttta tatacttttt ttaaatttac aagtctactt aaagacttct     7320

tataccccaa atgattaagt taattttaga ggtcaccttt ctcacagcag tgtcacttga     7380

aatttagtag ggaaggatat tgcagtattt ttcagtttcc ttagcacagc accacagaaa     7440

gcagcttatt ccttttgagt ggcagacact cgacggtgcc tgcccaactt tcctcctgag     7500

tggcaagcag atgagtctca gtaattcata ctgaaccaaa atgccacata cactaggggc     7560

agtcagaaac tggctgagaa atcccccgcc tcattcgccc ctctgctccc aggaactaga     7620

gtccagttaa agcccctatg cgaaaggccg aattccaccc cagggtttgt tataacagtg     7680

gccagtctga accccatttg ctcgtgctca aaacttgatt cccacttgaa agccttccgg     7740

gcgcgctgcc tcgttgcccc gcccctttgg caggagagag gcagtgggcg aggccgggct     7800

ggggccccgc ctcccactca cctgccggtg cctgaaatta tgtgcggccc cgcgggctgc     7860

tttccgaggt cagagtgccc tgctgctgtc tcagaggcat ctgttctgca aatcttagga     7920

agaaaaatgt ccctagtagc aaacgggtgt cttctgtgca taaataagta caacacaatt     7980

ctccgaaagt tcgggtaaaa agagatgcgg tagcagctgc cctgtgtgaa gctgtctacc     8040

ccgcatctct caggcgctaa gctcagtttt tgtttttgtt tttgtttttt taaagaaaag     8100

atgtataatt gcaggaattt ttttttattt ttttattttc catcattcta tatatgtgat     8160

ggtgaaagat atgcctggaa aagttttgtt ttgaaaagtt tattttctgc ttcgtcttca     8220

gttggcaaaa gctctcaatt ctttagcttc cagtttcttt tctctctttt tctttgttag     8280

gtaattaaag gtatgtaaac aaattatctc atgtagcagg ggattttcat gttgagagga     8340

atcttccgtg tgagttgttt ggtcacacaa ataacccttt ctcaatttta ggagtttgga     8400

ttgtcaaatg taggtttttc tcaaaggggg catataacta catattgact gccaagaact     8460

atgactgtag cactaatcag cacacataga gccacacaat tatttaattt ctaactctct     8520

gtggtcccta gaaaaattcc gttgatgtgc ttaggttaaa gttctgaaga tacccgttgt     8580

acccttactt gaaagtttct aatcttaagt tttatgaaat gcaataatat gtatcagcta     8640

gcaatatttc tgtgatcacc aacaactctc agtttgatct taaagtctga ataataaaac     8700

aaatcccagc agtaatacat ttcttaaacc tcacagtgca tgatatatct tttcattctg     8760

atcctgtgtt tgcaaaaata tacacatgta tatcatagtt cctcactttt tattcatttg     8820

ttttcctatt acctgtagta aatatattag ttagtacatg gaatttatag catcagctac     8880

ccccaggaac agcacctgac aggcggggga ttttttttca agttgttcta catttgcata     8940

aattatttct attattattc atgtatgtta tttatttctg aatcacacta gtcctgtgaa     9000

agtacaactg aaggcagaaa gtgttaggat tttgcatcta atgttcatta tcatggtatt     9060

gatggaccta agaaaataaa aattagacta agcccccaaa taagctgcat gcatttgtaa     9120

catgattagt agatttgaat atatagatgt agtattttgg gtatctaggt gttttatcat     9180

tatgtaaagg aattaaagta aaggactttg tagttgtttt tattaaatat gcatatagta     9240

gagtgcaaaa atatagcaaa aataaaaact aaaggtagaa aagcatttta gatatgcctt     9300

aatttagaaa ctgtgccagg tggccctcgg aatagatgcc aggcagagac cagtgcctgg     9360

gtggtgcctc ctcttgtctg ccctcatgaa gaagcttccc tcacgtgatg tagtgccctc     9420

gtaggtgtca tgtggagtag tgggaacagg cagtactgtt gagaggagag cagtgtgaga     9480

gtttttctgt agaagcagaa ctgtcagctt gtgccttgag gcttccagaa cgtgtcagat     9540

ggagaagtcc aagtttccat gcttcaggca acttagctgt gtacagaagc aatccagtgt     9600

ggtaataaaa agcaaggatt gcctgtataa tttattataa aataaaaggg attttaacaa     9660

ccaacaattc ccaacacctc aaaagcttgt tgcatttttt ggtatttgag gtttttatct     9720

gaaggttaaa gggcaagtgt ttggtataga agagcagtat gtgttaagaa aagaaaaata     9780

ttggttcacg tagagtgcaa attagaacta gaaagtttta tacgattatc attttgagat     9840

gtgttaaagt aggttttcac tgtaaaatgt attagtgttt ctgcattgcc atagggcctg     9900

gttaaaactt tctcttaggt ttcaggaaga ctgtcacata cagtaagctt ttttccttct     9960

gacttataat agaaaatgtt ttgaaagtaa aaaaaaaaaa tctaatttgg aaatttgact    10020

tgttagtttc tgtgtttgaa atcatggttc tagaaatgta gaaattgtgt atatcagata    10080

ctcatctagg ctgtgtgaac cagcccaaga tgaccaacat ccccacacct ctacatctct    10140

gtcccctgta tctcttcctt tctaccacta aagtgttccc tgctaccatc ctggcttgtc    10200

cacatggtgc tctccatctt cctccacatc atggaccaca ggtgtgcctg tctaggcctg    10260

gccaccactc ccaacttgac ctagccacat tcatctagag atggttcctg atgctgggca    10320

cagactgtgc tcatggcacc cattagaaat gcctctagca tctttgtatg catcttgatt    10380

tttaaaccaa gtcattgtac agagcattca gttttggctg tggtaccaag agaaaaacta    10440

atcaagaata taaaccacat tccaggctgc tgttttctct ccatctacag gccacacttt    10500

tactgtattt cttcatactt gaaattcatt ctgctatttt catatcaggg tacagactta    10560

taagggtgca tgttccttaa aggtgcataa ttattcttat tccgtttgct tatattgcta    10620

cagaatgctc tgttttggtg ctttgagttc tgcagaccca agaagcagtg tggaaattca    10680

ctgcctggga cacagtctta taagaatgtt ggcaggtgac tttgtatcag atgttgcttc    10740

tcttttctct gtacacagat tgagagttac cacagtggcc tgtcgggtcc accctgtggg    10800

tgcagcacag ctctctgaaa gcaagaacct tcctacctat tctaacgttt ttgccctcta    10860

agaaaaatgg cctcaggtat ggtatagaca tagcaagagg ggaagggctg tctcactcta    10920

gcaaccatcc ctccattaca cacagaaagc cctcttgaag caaaagaaga agaaagaaag    10980

aaagcttatc tctaaggcta ctgtcttcag aatgctctga gctgaatgct cttgctcctt    11040

tcccaagagg cagatgaaaa tatagccagt ttatctatac ccttcctatc tgaggaggag    11100

aatagaaaag tagggtaaat atgtaacgta aaatatgtca ttcaaggacc accaaaactt    11160

taagtaccct atcattaaaa atctggtttt aaaagtagct caagtaaggg atgctttgtg    11220

acccagggtt tctgaagtca gatagccatt cttacctgcc ccttactctg acttattggg    11280

aaagggagaa ctgcagtggt gtttctgttg cagtggcaaa ggtaacatgt cagaaaattc    11340

agagggttgc ataccaataa tcctttggaa actggatgtc ttactgggtg ctagaatgaa    11400

aatgtaggta tttattgtca gatgatgaag ttcattgttt ttttcaaaat tggtgttgaa    11460

atatcactgt ccaatgtgtt cacttatgtg aaagctaaat tgaatgaggc aaaaagagca    11520

aatagtttgt atatttgtaa taccttttgt atttcttaca ataaaaatat tggtagcaaa    11580

taaaaataat aaaaacaata actttaaact gctttctgga gatgaattac tctcctggct    11640

attttctttt ttactttaat gtaaaatgag tataactgta gtgagtaaaa ttcattaaat    11700

tccaagtttt agcagaaaaa aaaaaaaaaa aaa                                 11733


<210>  7
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Lys Asp Gly Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 
1               5                   10                  15      


Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 
            20                  25                  30          


Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 
        35                  40                  45              


Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val 
    50                  55                  60                  


Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg Leu Phe 
65                  70                  75                  80  


Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr Lys Leu Thr Leu 
                85                  90                  95      


Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 
            100                 105                 110         


Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 
        115                 120                 125             


Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 
145                 150                 155                 160 


Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 
                165                 170                 175     


Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu 
            180                 185                 190         


Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys Ile 
        195                 200                 205             


Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg Gly Ser Ser Asp 
    210                 215                 220                 


Val Asp Gln Leu Gly Lys Ile Leu Asp Val Ile Gly Leu Pro Gly Glu 
225                 230                 235                 240 


Glu Asp Trp Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 
                245                 250                 255     


Lys Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 
            260                 265                 270         


Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 
        275                 280                 285             


Ile Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp Leu Glu 
    290                 295                 300                 


Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro Ser Gln Asn Thr 
305                 310                 315                 320 


Ser Glu Leu Asn Thr Ala 
                325     


<210>  8
<211>  11534
<212>  DNA
<213>  Mus musculus

<400>  8
cccgcgctgc gctcatcccc gaggggcccc agcaacctct ccttcgtgaa gactgcacga       60

gccctgctgt ggaagaaaag tgcagagatt gtgggcagac tatgtaatcg ctgcggaggg      120

ggaagaggag ggatcggcgc tctcctgcgg cggcggcgcg gcgactcggc taggcggagt      180

ttcgcagcgg ctgcgcccgg cttgcacccg cgggcgagaa ggtcggtccg tctagcccgg      240

cggccgcgag tccgactccc cgaggcgtgt aaggcagcga gtgagcaccc cggttccact      300

gtgccgcacc cgcagcctga agccagcatg gagaaggaca gcctgagtcg cgccgatcag      360

cagtatgagt gcgtggcgga gatcggcgaa ggcgcctatg ggaaggtgtt caaggcccgc      420

gacctgaaga acggcggccg cttcgtggct ctgaagcgcg tgcgagtgca gaccagtgag      480

gagggcatgc cgctctccac catccgcgag gtggcggtgc tgaggcacct ggagaccttc      540

gagcacccca acgtggtcag gttgtttgat gtgtgcacag tgtcacggac ggacagagaa      600

accaagctta cactagtgtt tgagcatgtt gatcaagact tgaccactta cttggataaa      660

gttccagagc ccggcgtacc cacagaaacc ataaaggata tgatgtttca gcttctccga      720

ggtctggact ttcttcattc tcacagagta gtgcatcgtg atctgaaacc gcagaacatt      780

ctggtgacca gcagtggaca gataaagctg gctgactttg gccttgcccg catctatagt      840

tttcagatgg cccttacctc ggtggtcgtc acgctgtggt accgagcccc agaagtcctg      900

ctccagtcca gctatgccac ccctgtggac ctctggagtg tcggttgcat ctttgcagaa      960

atgtttcgca gaaagcctct ttttcgtgga agttcagacg tggatcaact aggaaaaatc     1020

ttggacatca ttggactccc aggagaggaa gactggccta gggacgtggc ccttccccgg     1080

caggcttttc attccaaatc tgctcaaccc atcgagaagt ttgtgacaga tattgacgaa     1140

ctaggcaaag acctacttct gaaatgcctg acgtttaatc cagctaaaag gatatccgcc     1200

tacggcgccc tgaatcaccc gtacttccaa gatctggaga gatacaagga caacctgaac     1260

tctcacctgc catccaacca gagcacctcg gagctgaaca cagcctgagg ttccacgggg     1320

atgcccatga gctcgtcatc tgaacacatt ggcggctgcg agtcccctaa gcaagcctct     1380

cagagcagtt gaagattgct ggctgccaac cttctggctg ccagcttctg ggtgggctct     1440

gccttaccaa ggaaaccacc tagtttactg ttcagagatc aatgcaaggg tgattgcagc     1500

tttatgttcg tttgtacact tgtttgtttt gtctgtttgt ttcaagaacc tggaaaactt     1560

ccagaagaag agaagctgct gaccaattgt gctgccattt cgttttctaa ccttgaatgc     1620

tgccagtgta gggtgggaat ccaggcccag ctgagttatg atgtaatccg cctgcagctg     1680

ctgggcctgc tttggtactt gtgagtgtgt gtgcatgcgt atgtgtgtgt aagagagaag     1740

aggaggggag agaaagaccc ctgatctcgt caagtgttac tttttttttg tagaaaacaa     1800

gaataattga gttttaaaga gtagaggtga ctgatagtaa gaagggcttg ttcagtgaaa     1860

ggtgattcac aatggagtct tgttaggaag gttggaccta agtcctcaga gttgccttcc     1920

tgtccaaaag cttttgctag cagtaaacaa taaaggttta gatgccacaa aaaatggggg     1980

gaaccacaat attttttaag agacttttta aggcatacat cttctattta ctctttggaa     2040

agctgaactt aatgtgtccc aggccctata tatagtacag tatgtactta attgtttctt     2100

tggggaaaga tgctataagt atcttattac ttgcaataca tttaaggagt gagtgtacct     2160

cagataggtt ttaaagatag agagcacctg ttttctggtg tgagatgtta tcattttctt     2220

cacgtctctt gataccttga taccttgtca ccttagggaa tcacttcctg ctctgactag     2280

aggcgggaat accatctagc tgtctccacc acccaccatg gcgcatctgc cttgtgctgc     2340

cttgtgtagt gcgaagctct caaccaccag cacttctaat tcattttcct gccactgcct     2400

ggctaacgac agatggccca gctgccccaa tcccacaccc gcttgcacgc ttaccgtctt     2460

tcaccgaatg ctttgggcgt aggctcccat tccgaaaccc taacagtatc cccttgtgcc     2520

tttgtaatac agtcttcccc ctgccgcagc tgaggtcacc taggcagtga agagtgcttg     2580

ttctgtgtgt gtatagacta ctaccgactg tcacttggtg tttcctatct ttaagtgtat     2640

gttgtcagtg taatgtctga ggaaatgtct tttcctctct tctagagata actacttact     2700

ctctaaagtg atctctctgt ctgtccgcag gatgtgtttc tgggtttttg ttcttttttt     2760

tttttttttt ttttttttgt ctgaggcctc atgtcagccc tgctttctgc agagccagcc     2820

taccctgggc attataaaca actgtacctt actgttttct ttcagtcctt tacattctgt     2880

gccacctttg ccttattata tccgtggctt agtgctaagc tggcactact ccatagaagg     2940

tgtagaaggc agctttcggg aagcgtagct gagttttgtt tgaatcgtgt ttgagcacat     3000

ttaagtaaac gctagatgat gcttcactgt agagctttga aagactgcct gatgtttcac     3060

acggcagtgt aggctccaga tggtgtttgt atgttatgga ccttactgtg tttctcgtag     3120

ctgaacaatg catgtggtta tttgtttgtt tgttttttgg tttctctgtg tagccctggc     3180

tgtcctggaa ctcactctgt agaccaggct ggcctcgaat tcagaaatgc gcctgcctct     3240

gcctcccaag tgctgggatc aaaggcgtgc gccaccacgc ccggctttgc atatggttat     3300

ctgtatggag aagaattaga tgtctttcct gagagctttg gaggttggga atcatcttct     3360

tctgtttatt tttattttta acattacatt acattcttct gattcagtat cgcaagaaag     3420

gattttttct tttttcaaaa acaaaacttt aagaagccag aggctaggct gagaatgttc     3480

tgcgctcgtc ctcacagctc tgctgccgac actgccaacg ctcgagacag tcagcctgga     3540

acctctggga caaggtctac tcgaggtctc acttggacag cgagttctgc cttgtcattg     3600

aacaaggtcc aaaatacaga catttttgct agggcctaga aatcgaccat aaaactcact     3660

gcattgaggc ctaatccatt ctatattaac atccatgtga taaagtgaaa ataattttga     3720

gggttttgct ttcgccaaaa aaaaaaaaga aagaaagaaa aaaaaagaaa ggaagaaaaa     3780

gaaaaaagaa aggattgttt tccttagctt tgctcaagaa aaatacagct atcctaaact     3840

ggaatcttcc cgtattcttt agagtcttaa gtatagagtt taacttcact tttgtcagct     3900

gtcttgagct tatttctaag tagttttgtt ttggcttttg gtgagtgagg tagtgggagg     3960

ttaattttgg ggtctttttt ttttttggct ttgtttgtgt gtgtgtgtgt gtgtgtgtgt     4020

ttatgtgttt ggcttttggg tttggttggt tagttgttta gtttgttttt ttgttgttgt     4080

ttaatttgct ttttctaggc agggtttctc tatgtggccc tggctgtcct agaacttgct     4140

ctgtagacca ggctagcctc aaactcagag atccacttgc ctctgtctcg agtgtgcttg     4200

aactaaaggc atgagctacc ctcctcagcc cactccaaac tttgagtaat atttttaaat     4260

catagacatg ttggtattag aaacatggcg tattgtggtg gatggtagag aaagggcgcc     4320

gcaacctctc aggacatcat atgtctggcc agctcttcat tcatataggt gctctctgga     4380

tatgtcttta catcagactc acacctctga aacccggttt tcacacaagg agacttgcca     4440

ttggggtctt tagtagccca gggaaacata gagtaaactg aagagcttac tgtgtgccgc     4500

ttatccttag atggcctcat ccagtcacag gtctttgtca gaatctaacc attgattcac     4560

tgaggagacc ctactgccct gaggttccac tgaagcagct tttagtgaga ctagggcaag     4620

aatataccga atagcttctg ttcaaggttt ggttccagag actctaccat ttacaggact     4680

ggctggagtt acaacaacct cttaaagagg gtagggcggg ttctccagtt agacccccta     4740

acctcacagg tgagtagtcc taacctgaca gccttagaaa cacagttgcc gagtacctga     4800

gagcacccag tggcccgccg cctcctattc agcccctctt taaagacgac agacggttaa     4860

gccatggaga agctgttcag gtagcacggg gccatttctg cccccagctt gtcatgtttt     4920

ttctctcagg acccactctc tgaccagtag acttgaattt agccccaagt gatttactaa     4980

actcagctca gaagctcact taaaaatagg acctccacat ggtcgtgcta agtaaaaatg     5040

aagaccccaa gttgcacagg gtgctgctat ctcaaagaca atactttcct ttgaatagaa     5100

agctgtgccg tccaccctgc aatgggtgct agccaacttg cttgagaaag tcaggagcaa     5160

gcattttgag ttttaaagaa tgtcctgaac ttgtctttta agtaaacata gctgctttat     5220

taaaagctgt gactactaaa gccagtcaca gccatcgtca ctgtgggagt taaatcatgt     5280

caactttcaa acatcacagt tgtttcaatc ttctgtccaa agaactcctc ttctggagaa     5340

aacctgattt tggttttggc tttttgtctt gtcttgtttt gtttttcctg agatggggtc     5400

tctctgtgaa gccctggcta tcctggaact cagtgtgtag accaggctgg ccttgaactc     5460

atgtagatct gcctgctaaa actaaagaca tgcaccacca tgacagctga ctatttttta     5520

tgatgagcac agaagtggct cacattttct taaagcacac ttttgtcaca tagtagagtc     5580

taggaaagaa taacattgaa aatccccatc ccagtgtgac acttgtgtaa gcacatatgg     5640

atagccattg gaagaataca tgcttgcttg taacatgaaa ttaaagacat tgtataattt     5700

cttaatcttt aaaaattacc aaaaaagtgg caacagtatg tttaaggtta ttttaatttt     5760

tacataaatt gttaaccata tttgtttgcc tttaagtata ttctaagaat tataattaag     5820

tataattata agtcatcccg cacattcagc acttatggac taggtatgtc aaaatacaca     5880

aattctgtat ttcttgtttc ataggaagaa agcagccatc tgaagctcta ctcatatata     5940

tgcctaagaa tatctataca aaattaaagt ttaaaaggcc tttgcctctc gtgcagctga     6000

gaatagacaa cttataagcc ttatccaaaa accatgataa agggatcatg tgcatcctta     6060

caaaaacccc ttatcctgtg catacttaca tccaagtaca tcctaaggaa ggtgtccgtg     6120

cattcatctg ccacagtggg gaagctgcct ggtgcaaggt gtgagtcctg gaatgattag     6180

tgatagtggt ctcaaatgag gacaccttcg tctcccacca gtttccttcc tatggacagg     6240

ctcagtccag ttatacaggc caggaggggc tggtgcccac agcctcccgc ctctgcaagg     6300

taggattgca tatctcaaac atctctaact cagtttcggc tttgttggtc ttgtttaagg     6360

aaataagcca gtaagccaaa actatttttg ttgttgttct cttgtcttct gaaagagagg     6420

ggatatcaat tttaaatgtt tctctcaatt tgatctttca aatttttcta ataaagtgcc     6480

aaattgctgc tgcttcttct tcttctttct tcttcttctt cttcttcttc ttcttcttct     6540

tcttcttctt cttcttcttc ttcttcttct tcttcttcat gttttctgct agggttttct     6600

tgttttgttt tggtttcagt ttgttttatt ttcagcaagt taggtaactt gagaggactt     6660

ccactaggat gttcacacct ctgtgctctg gtcctctgac ccctccaaaa aatagccacc     6720

tgggaataaa tgcaagctcc ccccctccag catctaccaa aatactgttg cagcaattcc     6780

aagttcaaat ggtggggatg gaaggtagtt tggagttggg ttgggttggg ttgggttagg     6840

ttggacagaa gtcagtttta aaattcacag cgccctaagg tcagtgtggg gtttattcct     6900

ctatcccaat gtgtttcaca aggtggcgct ttcagagaaa actctaaacc tgaccaagac     6960

tgagaggtat tctagagaca gtacttgtaa ctattttcct gcacatctgt aactatcacc     7020

tagcatattc cttcagacaa ttaacagcct tcataatatt ctacagctta tatgttttgc     7080

tttttagcta ggttctgagt gactaagtta ggcttgagag tgatgtttaa gcaataaaga     7140

aggcctttac ttaagagaca tttttgatgt acccaaataa cctgaaattc taggacatac     7200

aactaaaaac ttccctgaag ccggccctcg tctgtgagca gcacggtttc attagaaatg     7260

gcaaaactcc ttgcggggtt gggagtgggg gacagtccta actctcacag cccttgacat     7320

gtctgctgcg gttcacccct cactatccat gaccttttga cactgtcatt tctaaactca     7380

agtgaacaaa ggaagcactg catctgtaac tgagtatgca gaccattttc taaagaacca     7440

cagtgctcga caaatactgg aagaactggt atgttttaca cgcacataaa ctacaagtgc     7500

aaactcttac attccaattc ctaaattaca gttatatagt acatatgaac attacagttt     7560

agacaggaac ctgcataagg ctttggtttt tctactctcg aggtcacttt tatactacat     7620

tttaaattca cacttttctc agagacccag ccccctgagc caatagtgac agtacactgg     7680

gatgaacaga cacagtacca caccatggca gaaagcagtt tattccttat gagtcacaca     7740

cacacacaca cacaccctgc ctgacttcac acacacacac acacactgcc tgacttcaca     7800

cacacacacc ctgcctgact tcactccaga aaggctggca gggaggtttc agtcatttac     7860

acagaccagg tgctcaagca ttgagaaatc gattctttca accctctgct ctcactgaag     7920

cagatctcag gttaagcccc tcagtgaaag gccaagggtc ccctgggtct gccaccattc     7980

tggagttcct gagcctgacc ccacccctac tcctgctgaa tgacaggggg cggggcagcg     8040

gagccaggcc aagcaggata ttgtgggagg accagtgacc tgctgcacct cagccatctg     8100

ttgtgccatc ttaggaagca gggtgctcga gaaacacaga gctgtcctct gagctacaat     8160

aactacagtt tgctcactag gctagctagc tctggtgtag agatgcaagc cctatatgaa     8220

atgtctccca ctcaaagttt tgctgggggg tgggggttga gatgtataat tgcaggagaa     8280

attctgactt tactgttttc tatctgatac atccatggtg gggaaaagat atgaaactgt     8340

ctcagtttga aaagctcttc tacttcaatt ggcaaacgca tggagttcgt tactttctac     8400

tttcttcttt tttctccttt agtgagcaaa ttattccttg aacagaaaga ggattttccc     8460

atttagagga agcttctgtg tgaattgtca ggtcacacaa ataatgccat tatattgttg     8520

agtgtagggc tttggttttt caggggacac atagccaagc agtgatggtc aggaattatg     8580

tctcactcta tcatttctta ctcaagcagg gttccagcca gattctattg tgagctgagg     8640

ttagtcgggg gaccctgtgc tctacttgaa gtttcataat ctttagttct atgaaatgca     8700

ataacatata ttagccagca atattcctgt ggtcgccagc atctctgagt ttgaccttca     8760

gtctctggat ggttaaaata gatcccagca gtaatccatt tcttgacatc agtgcttaag     8820

tcaagtatct ttccactctg gtcctatttg caacaatgta ttcatgtatg tttcatttcc     8880

tttattcatt attttcctat gaacagtgat aaatgtatta gcacattgaa ttaatagcat     8940

aatagaaaga gcacttagca gatggggatt ttttatcaag tcccacattt acataagtta     9000

tttctattat tattcatgta tattatttat tgctaagcct cacaccattc ctgtgaaagt     9060

gcaactaaag gcagatatta gggcttggat ttaatgttcc ttatcatggt cttgaacaaa     9120

aaattcagtg atgcccccaa ataagctgcc tgcgttttta acacgactgc tagatttcag     9180

taggttaagt gtaacacttt tggtgtctag gtgtcttttt acattaaaag aggcaaagca     9240

gcagaactct gtagctattg cttctggcag agatttgttt agcatagtgt ggtattaatt     9300

atagcaaatg ttaaggtagc atgtagaggt tgccttcaat aagggactgt gccaggtggc     9360

cagcaaagtg gattctaggc agagcaggcg tctaggtgct gcctcctgtc tggttgtgtg     9420

aagagagctg ctccgagcaa tgtagtgccc ccgtgccccc gtaggtgtcc tgggcagcgg     9480

tgggaacacg tggtactgta gagaagggat cagcgtgagg ggtgttctgt aggaacagaa     9540

ctggtagcgt atgccttgag gcttcctgcc cgtgttttca gattccaggc atacattctg     9600

tatacagaag cagtccatcc tagcaataaa acctaggaat ccccaacaac tcaaaaggca     9660

gttgccctgc tgtggtttct gtcctgagct gaaggttaac gggcaagtgt taggcacaga     9720

agagcatcgt gtgctggggt gccgtgccac ggcccagggt gcgtgttagc agtagagact     9780

gttacagggt tgtcccttct aggtgcgtag aagtatatgg cttcactgta aagtgtgtat     9840

tgtttctgta ttcccacagg gacttgttaa agcttctaga ggcttcagca aagctgtaga     9900

ccacagtaag ctgctttttg tttgacttat tcttagacta ggaaatgttt aaaggttaaa     9960

aaaaaaaaaa aaagaatctt catttagaca ctgaactcgc tattttctgg actgaaatca    10020

tggtcctaga actgtagaaa tcacacccat tagatgctaa tctaggttgt gtaagccagc    10080

cccaagagtc tagcatcccc acactgtatc tgcatcttcc tgcatcttac cttccttccc    10140

gaaggtgctc cctaccacta ccctgacctg tccctttggt gcttcccatc tccttggctg    10200

aaagttaggc atcaagcatg tgatgagaaa tactttcagc accaagtatg cctgcctagg    10260

cctagccacc gcccccactt tgcctttggc tagccatagt caacaagaga taatacctgg    10320

tgctgggcac agaatgaacc catgatgtca gtcagaaaag ccctcaagca tatttctcct    10380

gtacgtcctg atctttaaac ccagtcatta tgcagagcgt tcgctgttgg ctatagtccc    10440

aggttaaaaa aaaaaaaaac attccaggct gctgtaggct gtccatatgc agtctctgct    10500

tttaccttgc tttttcatac ttgaaattcg ttctgccatt ttgatttcac ggtgcagaca    10560

tcagggtaca cgttccctct gggtgcataa ttgctctcat tccgtttgct cacactgcta    10620

caggatgctc tgttttggtg ctttgggttc agcgggtcaa aaagcactgt gggaaatcac    10680

tgcctagaac acagtcttaa aagcatttgg gcaggagtct tggtgttgat gtcgcttctg    10740

ctcttctctg tgccctccag atggagttac caggttggcc tgccaggtcc cccactccca    10800

cccccaagac ctttctctga atggcctgtg aaccctgtgc tgtatccaag ggtgaatgtg    10860

acgtatctcc tctggcgacc ctacctttcc tggttactca ccatcagaaa caacctaggt    10920

tacatatagc aaactctaca cagccttcct gagggaaagc ataaaaggat atctctaagg    10980

ttgctcttca aagccctgag ctgaaggcct ttgctcccgt ccttggagct gatgaaaata    11040

ctggtcaatt tatccaagcc cttcccactt acaagaatgg gaaagtagag gtttgtgtcg    11100

ataccatcta aagaccacaa cttctagcca tagggtattt catatatgtc cattttcaaa    11160

agcagctcag gtgagtggtg actccaggct ccatgcaggc atcttaacat gggacttccc    11220

tagagagagc tacagtgttc attctatgtc acagggcagg agaggagacc ggcaggaaat    11280

ttggagggta acagatcaat actcctttgg aaactggatg tcttactggg tgctagaatg    11340

caaatttatg tatttattgt ctggtcattg aattcattgc ctttcaaaac cattgttcaa    11400

atgtcactat cattggcctc acttgtatgc cagccgaatt ggttgaaagc aaaccagaga    11460

atggtttgtg catttgcctt accatttgta cttcttacaa taaaaatgtc agtagcaaat    11520

aaaaaaaaaa aaaa                                                      11534


<210>  9
<211>  326
<212>  PRT
<213>  Mus musculus

<400>  9

Met Glu Lys Asp Ser Leu Ser Arg Ala Asp Gln Gln Tyr Glu Cys Val 
1               5                   10                  15      


Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 
            20                  25                  30          


Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 
        35                  40                  45              


Thr Ser Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val 
    50                  55                  60                  


Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg Leu Phe 
65                  70                  75                  80  


Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr Lys Leu Thr Leu 
                85                  90                  95      


Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 
            100                 105                 110         


Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 
        115                 120                 125             


Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 
145                 150                 155                 160 


Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 
                165                 170                 175     


Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu 
            180                 185                 190         


Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys Ile 
        195                 200                 205             


Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg Gly Ser Ser Asp 
    210                 215                 220                 


Val Asp Gln Leu Gly Lys Ile Leu Asp Ile Ile Gly Leu Pro Gly Glu 
225                 230                 235                 240 


Glu Asp Trp Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 
                245                 250                 255     


Lys Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 
            260                 265                 270         


Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 
        275                 280                 285             


Ile Ser Ala Tyr Gly Ala Leu Asn His Pro Tyr Phe Gln Asp Leu Glu 
    290                 295                 300                 


Arg Tyr Lys Asp Asn Leu Asn Ser His Leu Pro Ser Asn Gln Ser Thr 
305                 310                 315                 320 


Ser Glu Leu Asn Thr Ala 
                325     


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  10
atgaacgcta cacactgcat c                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  11
ccatcctttt gccagttcct c                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  12
ggacttgcct tgttccgaga g                                                 21


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  13
gctgccacat aactgatagc ga                                                22


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  14
ctggcggaca tggctttact t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  15
ctcccacttt tagcagtccc c                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  16
ggcctgtcta agaaacctgc c                                                 21


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  17
ccaccttgaa gtatagcttt ggg                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  18
taatggagac tcattccctt gga                                               23


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  19
aaagtcagag tgctgaggtt tg                                                22


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  20
gctgagagca tccgactgaa c                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  21
aggtacatca agctcgaagc a                                                 21


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  22
tagtccttcc taccccaatt tcc                                               23


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  23
ttggtcctta gccactcctt c                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  24
gaggctatcc agcgtactcc a                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  25
cggcaggcat actcatcttt t                                                 21


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  26
accctcgtcc tgctactctc                                                   20


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  27
ctgtctcctc gtcccaatac t                                                 21


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  28
cagttcgtga ggttcgacag                                                   20


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  29
cagccgtaca tgctctgga                                                    19


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  30
ggacaagagc agagatacac g                                                 21


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  31
caaggacagc taggacaacc                                                   20


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  32
cagcttgact caaaattcct gga                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  33
tgaagattac gcttgctttt cct                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  34
actcacctct tcagaacgaa ttg                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer 
       sequence"

<400>  35
ccatctttgg aaggttcagg ttg                                               23