                         SEQUENCE LISTING

<110>  Zhu, Zhenglun
 
<120>  METHODS OF TREATING NEOPLASTIC DISEASES

<130>  218008-0007PCT

<150>  US 62/477,754
<151>  2017-03-28

<150>  US 62/516,401
<151>  2017-06-07

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  2428
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (12)..(788)

<400>  1
acctggccgc c atg cgc ctc tcc tcc tcc cca cct cgt ggc ccg cag cag        50
             Met Arg Leu Ser Ser Ser Pro Pro Arg Gly Pro Gln Gln          
             1               5                   10                       

ctc tcc agc ttt ggc tcc gtg gac tgg ctc tcc cag agc agc tgc tca         98
Leu Ser Ser Phe Gly Ser Val Asp Trp Leu Ser Gln Ser Ser Cys Ser           
    15                  20                  25                            

ggg ccg acc cac acc ccc agg cct gcc gac ttc tcc ctg ggg agc ctc        146
Gly Pro Thr His Thr Pro Arg Pro Ala Asp Phe Ser Leu Gly Ser Leu           
30                  35                  40                  45            

cct ggc cca ggc cag aca tcc ggc gcc cgg gag ccc cct cag gcc gtc        194
Pro Gly Pro Gly Gln Thr Ser Gly Ala Arg Glu Pro Pro Gln Ala Val           
                50                  55                  60                

agc atc aag gag gcc gcc ggg tcc tca aat ctg cct gcg ccg gag agg        242
Ser Ile Lys Glu Ala Ala Gly Ser Ser Asn Leu Pro Ala Pro Glu Arg           
            65                  70                  75                    

acc atg gcc ggg ttg agt aag gag cca aat acc ttg cgg gcc ccc cgt        290
Thr Met Ala Gly Leu Ser Lys Glu Pro Asn Thr Leu Arg Ala Pro Arg           
        80                  85                  90                        

gtc cgc aca gcc ttc acc atg gag cag gtc cgc acc ttg gag ggc gtc        338
Val Arg Thr Ala Phe Thr Met Glu Gln Val Arg Thr Leu Glu Gly Val           
    95                  100                 105                           

ttc cag cac cac cag tac ctg agc cct ctg gag cgg aag agg ctg gcc        386
Phe Gln His His Gln Tyr Leu Ser Pro Leu Glu Arg Lys Arg Leu Ala           
110                 115                 120                 125           

agg gag atg cag ctc tca gag gtc cag ata aaa acc tgg ttt cag aat        434
Arg Glu Met Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln Asn           
                130                 135                 140               

cgc cgc atg aaa cac aaa cgg caa atg cag gac ccc cag ctg cac agc        482
Arg Arg Met Lys His Lys Arg Gln Met Gln Asp Pro Gln Leu His Ser           
            145                 150                 155                   

ccc ttc tcg ggg tct ctc cat gcg ccc cca gct ttc tac tca acg tct        530
Pro Phe Ser Gly Ser Leu His Ala Pro Pro Ala Phe Tyr Ser Thr Ser           
        160                 165                 170                       

tct ggc ctt gcc aat ggc ctg cag ctg ctg tgc cct tgg gca ccc ctg        578
Ser Gly Leu Ala Asn Gly Leu Gln Leu Leu Cys Pro Trp Ala Pro Leu           
    175                 180                 185                           

tcc ggg ccc cag gct ctg atg ctg ccc cct ggc tcc ttc tgg ggt ctc        626
Ser Gly Pro Gln Ala Leu Met Leu Pro Pro Gly Ser Phe Trp Gly Leu           
190                 195                 200                 205           

tgc caa gtg gca caa gag gcc ctg gca tct gcg gga gct tcc tgc tgc        674
Cys Gln Val Ala Gln Glu Ala Leu Ala Ser Ala Gly Ala Ser Cys Cys           
                210                 215                 220               

ggg cag cct ctg gcg tcc cac ccc cct acc cca ggc cgg cct tcg ctg        722
Gly Gln Pro Leu Ala Ser His Pro Pro Thr Pro Gly Arg Pro Ser Leu           
            225                 230                 235                   

gga cca gcc ctg tcc acg ggg ccc cgg ggc ctg tgt gct atg cca cag        770
Gly Pro Ala Leu Ser Thr Gly Pro Arg Gly Leu Cys Ala Met Pro Gln           
        240                 245                 250                       

acg ggg gat gca ttt tga ggaggcacct ctgactccca cactcgcggt               818
Thr Gly Asp Ala Phe                                                       
    255                                                                   

cttgctgatc gcacctggct cctacctgga ggactcagtt gttctgttta catcctggtg      878

gcacctctca ccctgaccca cacaaaggtt ctggagatta ctggagaata tatataaata      938

tatatatgta cgtatatatg taaatacaca tatacgtata tataaatata tatatacata      998

tgtgtgtgta tatatatata tatttttttt tttttttttt tttttgagac ggagtgttgc     1058

tctgtcaccc aggctggagt gcaatgacgc aatctcggct cactgcaacc tccgcctcct     1118

gggttcaagc gattctccag cctcagcctc ccgagtagct gggattacag acacccgcca     1178

ccacgcccgg ctaatttttt ctatttttag tagaaatggg gtttcaccat gttagccagg     1238

ctggtctcaa actcctgacc ctgtgatccg cccgcctcgg cctcccaaag tgctgggatt     1298

acaggcatga gccactgcac ccggccctga gaatatattt attaaagcca cctcttcact     1358

gaaagttacc gaaagagtcg gtttaggaag gaaacgaagg gtcagtgaac agagtcaaat     1418

gcagaagtgg gcttgtcatg ggtagggctt tcggcgtacg ataaaaggat catttgtttt     1478

ttaaaagggg ttggaaaaac tggttttcca gttggaaaca gtaaaggttg taagctttgt     1538

gtgtacaaaa gaaaacaggg aatgcaggtg tgtttatagc gttgtggttc aagtccctct     1598

taacaagaac tccaaagctg gaaagcagga gggaacaaag gtgaacatga aggcgaggat     1658

gctggggccc tgcagtgcgc tctaggctgt gcgtgagccg ggactgtacc cacagcttgc     1718

tgagggctgc tcttcttggg ccagggaaag cagggcagcc gggacctgcg gctgtgcctg     1778

gactgaagct gtcccgcagg tccccaccct ccaacacgtg ctcacctgtc cccctcctcg     1838

cagcagcctc gggacaaaac aatgactcaa ggacagcact tctcgcagaa ggtctggaag     1898

tgcccagaat gggaggcacg gaagcccctc ccggggagga ctcccgcgtt gatggaccgt     1958

tcttggtgca gactcctgac tgcgtgcatg aaacctgaga caagtgcaat tccttccatg     2018

tcgccccaga gtgcccagga ggcaggcagt gcggggtgcc caggcagacg ggttcagcct     2078

gcagaactgg aggcgacctg tgaaacccac ccgggcaccc caacaggaac agaagcgtgg     2138

tcctgcggct gcgtccccag cgagtttcac tttccccttg ctcgtttctc ccttgttgta     2198

agtgtttaca actggcatgt gcttttaaac gtcaggtaag aggggaacag ctgctgtaca     2258

tcgtcctggc gagtgacaat gtgacagaag cctgggcgag gccctcggag ggcagcagct     2318

ggacaggggc tactgggttt ggcctggaca gcactgattt gtggatgtgg atgggggcac     2378

gttgtccgtg ataaaagtac aagtgcccct cacaaaaaaa aaaaaaaaaa                2428


<210>  2
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Leu Ser Ser Ser Pro Pro Arg Gly Pro Gln Gln Leu Ser Ser 
1               5                   10                  15      


Phe Gly Ser Val Asp Trp Leu Ser Gln Ser Ser Cys Ser Gly Pro Thr 
            20                  25                  30          


His Thr Pro Arg Pro Ala Asp Phe Ser Leu Gly Ser Leu Pro Gly Pro 
        35                  40                  45              


Gly Gln Thr Ser Gly Ala Arg Glu Pro Pro Gln Ala Val Ser Ile Lys 
    50                  55                  60                  


Glu Ala Ala Gly Ser Ser Asn Leu Pro Ala Pro Glu Arg Thr Met Ala 
65                  70                  75                  80  


Gly Leu Ser Lys Glu Pro Asn Thr Leu Arg Ala Pro Arg Val Arg Thr 
                85                  90                  95      


Ala Phe Thr Met Glu Gln Val Arg Thr Leu Glu Gly Val Phe Gln His 
            100                 105                 110         


His Gln Tyr Leu Ser Pro Leu Glu Arg Lys Arg Leu Ala Arg Glu Met 
        115                 120                 125             


Gln Leu Ser Glu Val Gln Ile Lys Thr Trp Phe Gln Asn Arg Arg Met 
    130                 135                 140                 


Lys His Lys Arg Gln Met Gln Asp Pro Gln Leu His Ser Pro Phe Ser 
145                 150                 155                 160 


Gly Ser Leu His Ala Pro Pro Ala Phe Tyr Ser Thr Ser Ser Gly Leu 
                165                 170                 175     


Ala Asn Gly Leu Gln Leu Leu Cys Pro Trp Ala Pro Leu Ser Gly Pro 
            180                 185                 190         


Gln Ala Leu Met Leu Pro Pro Gly Ser Phe Trp Gly Leu Cys Gln Val 
        195                 200                 205             


Ala Gln Glu Ala Leu Ala Ser Ala Gly Ala Ser Cys Cys Gly Gln Pro 
    210                 215                 220                 


Leu Ala Ser His Pro Pro Thr Pro Gly Arg Pro Ser Leu Gly Pro Ala 
225                 230                 235                 240 


Leu Ser Thr Gly Pro Arg Gly Leu Cys Ala Met Pro Gln Thr Gly Asp 
                245                 250                 255     


Ala Phe 
        


