                         SEQUENCE LISTING

<110>  Yissum Research Development Co. of the Hebrew University of
        Jerusalem Ltd
 
<120>  TRANSFORMED ORGANISMS WITH STINGING CELLS EXPRESSING AN EXOGENOUS
        PROTEIN OF INTEREST

<130>  37299/WO/18

<150>  US 62/477,527
<151>  2017-03-28

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Suitable for CRISPR-CAS9 genomic targeted integration of a 
       transforming sequence


<220>
<221>  Guide RNA (gRNA)
<222>  (3)..(22)

<220>
<221>  Trans-Activating CRISPR RNA (tracrRNA)
<222>  (23)..(101)

<400>  1
ggcaguaguu agggcauccc ggguuuuaga gcuagaaaua gcaguuaaaa uaaggcuagu       60

ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu u                          101


<210>  2
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Suitable for genomic targeted integration of Interferon beta-1a 
       under the expression control of an endogenous stinging 
       cell-specific gene control element in its original genomic 
       location


<220>
<221>  mOrange2 (detectable label protein)
<222>  (1)..(708)

<220>
<221>  Flexible linker
<222>  (709)..(735)

<220>
<221>  P2A (self-cleavable sequence)
<222>  (736)..(801)

<220>
<221>  NEP3 Signal peptide
<222>  (802)..(897)

<220>
<221>  Interferon beta-1a
<222>  (898)..(1398)

<400>  2
atggtgagca agggcgagga gaataacatg gcaatcatca aggagttcat gagattcaag       60

gtgagaatgg agggctcagt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

agaccatacg agggctttca gacagcaaag ctgaaggtga caaagggtgg cccactgcca      180

ttcgcatggg acatcctgtc cccacatttc acatacggct caaaggcata cgtgaagcac      240

ccagcagaca tcccagacta cttcaagctg tcattcccag agggcttcaa gtgggagaga      300

gtgatgaact acgaggacgg cggcgtggtg acagtgacac aggactcatc actccaagac      360

ggcgagttca tctacaaggt gaagctgaga ggcacaaact tcccatcaga cggcccagtg      420

atgcagaaga agacaatggg ctgggaggca tcatcagaga gaatgtaccc agaggacggc      480

gcactgaagg gcaagatcaa gatgagactg aagctgaagg acggcggcca ctacacatca      540

gaggtgaaga caacatacaa ggcaaagaag ccagtgcagc tgcccggcgc atacatcgtg      600

gacatcaagc tggacatcac atcacacaac gaggactaca caatcgtgga acagtacgaa      660

agagcagagg gcagacactc aacaggcggc atggacgagc tgtacaaggg cggctctggc      720

gggtctgggg ggtctgggag tggtgctacc aacttttccc tcttgaaaca ggcaggcgat      780

gttgaggaaa atcctggacc catgaagctg acatacatcc tgcttattgc agttgtcggt      840

gtcgctatag aggccaaaag cgtcaagaaa tcaaaggccc atcataaaaa aaaaaggatg      900

tcttataacc tcttgggatt cctgcaaagg tcctcaaact tccagtgcca gaagttgctc      960

tggcaactga atggccgact tgagtattgc ctcaaagaca ggatgaattt tgatataccg     1020

gaagagataa aacagctgca gcaatttcag aaggaagacg cggcacttac aatatacgaa     1080

atgctgcaga atatatttgc tatattcagg caggattcta gtagtacagg ctggaacgag     1140

acgatcgttg agaatttgtt ggctaatgtt taccaccaaa tcaaccactt gaagacggtt     1200

ttggaggaaa agctcgaaaa ggaggatttc actagaggga aacttatgtc ctccctgcac     1260

ctgaagaggt attatggtcg aattctccac tatcttaaag caaaagaata ctctcattgt     1320

gcttggacta ttgtaagggt tgaaatcctg agaaacttct actttattaa taggctgaca     1380

ggttaccttc ggaactaa                                                   1398


