               SEQUENCE LISTING

<110> NESTEC S.A.

<120> METHODS OF MODULATING ANK1

<130> 15946-WO

<160> 6

<170> BiSSAP 1.2

<210> 1
<211> 1880
<212> PRT
<213> Homo sapiens


<400> 1
Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Thr Ser Phe 
1               5                   10                  15      
Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          
Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              
Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  
Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn Thr 
65                  70                  75                  80  
Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      
Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         
Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             
Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp Gly 
    130                 135                 140                 
Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 
Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     
Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val Leu 
            180                 185                 190         
Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe Thr 
        195                 200                 205             
Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 
Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly Ile 
225                 230                 235                 240 
Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     
Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp Glu 
            260                 265                 270         
Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             
Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys Asn 
    290                 295                 300                 
Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 
Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr Leu 
                325                 330                 335     
Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         
Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             
Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 
Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 
Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     
Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         
Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             
His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 
Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 
Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     
Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         
Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             
Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala 
    530                 535                 540                 
Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 
His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala 
                565                 570                 575     
Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         
Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His Ile 
        595                 600                 605             
Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 
Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu His 
625                 630                 635                 640 
Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     
Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro Leu 
            660                 665                 670         
His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             
Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr Pro 
    690                 695                 700                 
Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 
Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr Ser 
                725                 730                 735     
Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr Leu 
            740                 745                 750         
Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Thr 
        755                 760                 765             
Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr Asp 
    770                 775                 780                 
Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 
Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     
Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         
Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             
Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 
Ala Met Pro Glu Thr Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 
Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr 
                885                 890                 895     
Glu Thr Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Thr Gly 
            900                 905                 910         
Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             
Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Thr Cys Ala 
    930                 935                 940                 
Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 
Thr Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     
Ala Leu Gly Pro Thr Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         
Ile Pro His Phe Ala Ser His Gly Arg Gly Asp Arg Glu Leu Val Val 
        995                 1000                1005            
Leu Arg Ser Glu Asn Gly Ser Val Trp Lys Glu His Arg Ser Arg Tyr 
    1010                1015                1020                
Gly Glu Ser Tyr Leu Asp Gln Ile Leu Asn Gly Met Asp Glu Glu Leu 
1025                1030                1035                1040
Gly Ser Leu Glu Glu Leu Glu Lys Lys Arg Val Cys Arg Ile Ile Thr 
                1045                1050                1055    
Thr Asp Phe Pro Leu Tyr Phe Val Ile Met Ser Arg Leu Cys Gln Asp 
            1060                1065                1070        
Tyr Asp Thr Ile Gly Pro Glu Gly Gly Ser Leu Lys Ser Lys Leu Val 
        1075                1080                1085            
Pro Leu Val Gln Ala Thr Phe Pro Glu Asn Ala Val Thr Lys Arg Val 
    1090                1095                1100                
Lys Leu Ala Leu Gln Ala Gln Pro Val Pro Asp Glu Leu Val Thr Lys 
1105                1110                1115                1120
Leu Leu Gly Asn Gln Ala Thr Phe Ser Pro Ile Val Thr Val Glu Pro 
                1125                1130                1135    
Arg Arg Arg Lys Phe His Arg Pro Ile Gly Leu Arg Ile Pro Leu Pro 
            1140                1145                1150        
Pro Ser Trp Thr Asp Asn Pro Arg Asp Ser Gly Glu Gly Asp Thr Thr 
        1155                1160                1165            
Ser Leu Arg Leu Leu Cys Ser Val Ile Gly Gly Thr Asp Gln Ala Gln 
    1170                1175                1180                
Trp Glu Asp Ile Thr Gly Thr Thr Lys Leu Val Tyr Ala Asn Glu Cys 
1185                1190                1195                1200
Ala Asn Phe Thr Thr Asn Val Ser Ala Arg Phe Trp Leu Ser Asp Cys 
                1205                1210                1215    
Pro Arg Thr Ala Glu Ala Val Asn Phe Ala Thr Leu Leu Tyr Lys Glu 
            1220                1225                1230        
Leu Thr Ala Val Pro Tyr Met Ala Lys Phe Val Ile Phe Ala Lys Met 
        1235                1240                1245            
Asn Asp Pro Arg Glu Gly Arg Leu Arg Cys Tyr Cys Met Thr Asp Asp 
    1250                1255                1260                
Lys Val Asp Lys Thr Leu Glu Gln His Glu Asn Phe Val Glu Val Ala 
1265                1270                1275                1280
Arg Ser Arg Asp Ile Glu Val Leu Glu Gly Met Ser Leu Phe Ala Glu 
                1285                1290                1295    
Leu Ser Gly Asn Leu Val Pro Val Lys Lys Ala Ala Gln Gln Arg Ser 
            1300                1305                1310        
Phe His Phe Gln Ser Phe Arg Glu Asn Arg Leu Ala Met Pro Val Lys 
        1315                1320                1325            
Val Arg Asp Ser Ser Arg Glu Pro Gly Gly Ser Leu Ser Phe Leu Arg 
    1330                1335                1340                
Lys Ala Met Lys Tyr Glu Asp Thr Gln His Ile Leu Cys His Leu Asn 
1345                1350                1355                1360
Ile Thr Met Pro Pro Cys Ala Lys Gly Ser Gly Ala Glu Asp Arg Arg 
                1365                1370                1375    
Arg Thr Pro Thr Pro Leu Ala Leu Arg Tyr Ser Ile Leu Ser Glu Ser 
            1380                1385                1390        
Thr Pro Gly Ser Leu Ser Gly Thr Glu Gln Ala Glu Met Lys Met Ala 
        1395                1400                1405            
Val Ile Ser Glu His Leu Gly Leu Ser Trp Ala Glu Leu Ala Arg Glu 
    1410                1415                1420                
Leu Gln Phe Ser Val Glu Asp Ile Asn Arg Ile Arg Val Glu Asn Pro 
1425                1430                1435                1440
Asn Ser Leu Leu Glu Gln Ser Val Ala Leu Leu Asn Leu Trp Val Ile 
                1445                1450                1455    
Arg Glu Gly Gln Asn Ala Asn Met Glu Asn Leu Tyr Thr Ala Leu Gln 
            1460                1465                1470        
Ser Ile Asp Arg Gly Glu Ile Val Asn Met Leu Glu Gly Ser Gly Arg 
        1475                1480                1485            
Gln Ser Arg Asn Leu Lys Pro Asp Arg Arg His Thr Asp Arg Asp Tyr 
    1490                1495                1500                
Ser Leu Ser Pro Ser Gln Met Asn Gly Tyr Ser Ser Leu Gln Asp Glu 
1505                1510                1515                1520
Leu Leu Ser Pro Ala Ser Leu Gly Cys Ala Leu Ser Ser Pro Leu Arg 
                1525                1530                1535    
Ala Asp Gln Tyr Trp Asn Glu Val Ala Val Leu Asp Ala Ile Pro Leu 
            1540                1545                1550        
Ala Ala Thr Glu His Asp Thr Met Leu Glu Met Ser Asp Met Gln Val 
        1555                1560                1565            
Trp Ser Ala Gly Leu Thr Pro Ser Leu Val Thr Ala Glu Asp Ser Ser 
    1570                1575                1580                
Leu Glu Cys Ser Lys Ala Glu Asp Ser Asp Ala Thr Gly His Glu Trp 
1585                1590                1595                1600
Lys Leu Glu Gly Ala Leu Ser Glu Glu Pro Arg Gly Pro Glu Leu Gly 
                1605                1610                1615    
Ser Leu Glu Leu Val Glu Asp Asp Thr Val Asp Ser Asp Ala Thr Asn 
            1620                1625                1630        
Gly Leu Ile Asp Leu Leu Glu Gln Glu Glu Gly Gln Arg Ser Glu Glu 
        1635                1640                1645            
Lys Leu Pro Gly Ser Lys Arg Gln Asp Asp Ala Thr Gly Ala Gly Gln 
    1650                1655                1660                
Asp Ser Glu Asn Glu Val Ser Leu Val Ser Gly His Gln Arg Gly Gln 
1665                1670                1675                1680
Ala Arg Ile Thr His Ser Pro Thr Val Ser Gln Val Thr Glu Arg Ser 
                1685                1690                1695    
Gln Asp Arg Leu Gln Asp Trp Asp Ala Asp Gly Ser Ile Val Ser Tyr 
            1700                1705                1710        
Leu Gln Asp Ala Ala Gln Gly Ser Trp Gln Glu Glu Val Thr Gln Gly 
        1715                1720                1725            
Pro His Ser Phe Gln Gly Thr Ser Thr Met Thr Glu Gly Leu Glu Pro 
    1730                1735                1740                
Gly Gly Ser Gln Glu Tyr Glu Lys Val Leu Val Ser Val Ser Glu His 
1745                1750                1755                1760
Thr Trp Thr Glu Gln Pro Glu Ala Glu Ser Ser Gln Ala Asp Arg Asp 
                1765                1770                1775    
Arg Arg Gln Gln Gly Gln Glu Glu Gln Val Gln Glu Ala Lys Asn Thr 
            1780                1785                1790        
Phe Thr Gln Val Val Gln Gly Asn Glu Phe Gln Asn Ile Pro Gly Glu 
        1795                1800                1805            
Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn Ile Val Thr 
    1810                1815                1820                
Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu Ser Ser Ala 
1825                1830                1835                1840
Asp Ala Ala Gln Glu His Glu Glu Val Glu Leu Arg Gly Ser Gly Leu 
                1845                1850                1855    
Gln Pro Asp Leu Ile Glu Gly Arg Lys Gly Ala Gln Ile Val Lys Arg 
            1860                1865                1870        
Ala Ser Leu Lys Arg Gly Lys Gln 
        1875                1880

<210> 2
<211> 8300
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..8300
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 2
agaggctgcg gtgagtccgc cagccccagc tgctcctcct caagccccca aggcccttcg       60

gcgggcccct gctgaaagac cggcatgccc tattctgtgg gcttccgcga agccgatgct      120

gctaccagct ttctgagagc agcaagatca ggtaacttgg acaaagcttt ggatcacctg      180

cggaatgggg tagatattaa cacctgtaac cagaatgggt tgaatggctt gcatctggct      240

tctaaggaag gccatgtgaa aatggtggtt gaacttctgc acaaagaaat cattctagaa      300

acgacaacca agaaggggaa cacggccctg cacatcgctg ctctagccgg gcaggatgag      360

gtggtccggg agcttgtcaa ctatggagcc aacgtcaacg cccagtcaca gaaaggtttt      420

acacccctgt acatggcagc acaagagaac cacttggaag tggttaagtt tttactggaa      480

aatggagcta accagaatgt agccacagaa gacggcttca cgcctctggc ggtagccctg      540

cagcagggcc atgagaacgt cgtcgcgcac ctcatcaact acggcaccaa ggggaaggtg      600

cgcctcccgg ccctgcacat cgcggcccgc aacgacgaca cgcgcacggc tgcggtgctg      660

ctgcagaacg accccaaccc ggacgtgctt tccaagacgg gattcacgcc cctgcacatt      720

gcggctcact acgagaacct caacgtggcc cagttgctcc tcaacagagg agccagcgtc      780

aatttcacac cacagaacgg catcacgcca ctgcacatcg cctcccgcag gggcaacgtg      840

atcatggtgc ggctgctgct ggatcgggga gcccagatag aaaccaagac caaggacgaa      900

ttgacacctc tccactgtgc agctcgaaat gggcacgtgc gaatctcaga gatcctgctg      960

gaccacgggg caccaatcca agccaaaacc aagaacggcc tgtccccaat tcacatggcg     1020

gctcagggag accacctcga ctgtgtccgg ctcctgttgc aatacgacgc agagatagac     1080

gacatcaccc tggaccacct gaccccactc cacgtggctg cccactgtgg acaccacagg     1140

gtggctaagg tccttctgga taaaggggcc aaacccaact ccagagccct gaatggcttt     1200

acccccttac acatcgcctg caaaaagaac cacgtccgtg tcatggagct gctgctgaag     1260

acgggagcct cgatcgacgc ggtcaccgag tctggcctga cacctctcca cgtggcctcc     1320

ttcatggggc accttcccat cgtgaagaac ctcctgcagc ggggggcgtc gcccaacgtc     1380

tccaacgtga aagtggagac cccgctacac atggcagcca gagccgggca cacggaagtg     1440

gccaaatatt tactccagaa caaagccaaa gtcaatgcca aggccaagga tgaccagacc     1500

ccacttcact gtgcagctcg catcggccac acaaacatgg tgaagctcct gctggaaaat     1560

aacgccaacc ccaacctggc caccaccgcc gggcacaccc ccctgcacat tgcagcccgt     1620

gagggccatg tggaaacagt cctggccctt ctggaaaagg aagcatccca ggcctgcatg     1680

accaagaaag gatttacccc tctgcacgtg gcggccaagt acgggaaggt gcgggtggca     1740

gagctgctgc tggagcggga cgcacacccg aatgctgccg gaaaaaatgg cctgaccccc     1800

ctgcacgtgg ccgtccatca caacaacctg gacatcgtca agctgctgct tccccggggc     1860

ggctccccgc acagccctgc ctggaatggc tacacccctt tgcacatcgc tgccaagcag     1920

aaccaggtgg aggtggcccg tagtctgctg cagtatgggg gctcagcaaa cgccgagtcg     1980

gtgcaaggtg tgacgcccct tcacctggcc gcccaggagg gccacgcaga gatggtggct     2040

ctgctgctct cgaaacaagc caatggcaac ctggggaaca agagcggact cactcccctc     2100

catctggtag cacaagaagg ccacgttcca gtggcagatg tgctgatcaa acacggcgtc     2160

atggtggacg ccaccacccg gatgggctac actcccctcc atgtggccag tcactatgga     2220

aacatcaagc tggtgaagtt tctgctgcag caccaggcag atgtcaatgc caagaccaag     2280

ctaggataca gccccctgca ccaggcagcc cagcagggac acacagacat cgtgactctg     2340

cttctgaaaa acggtgcttc cccaaacgag gtcagctcgg atggaaccac acctctggcc     2400

atagccaagc gcttgggcta catttctgtc accgacgtgc tcaaggtcgt cacggatgaa     2460

accagtttcg tgttagtcag tgataagcat cgaatgagtt tccctgagac agttgatgag     2520

atcctggatg tctcggaaga tgaaggggaa gaactcatca gcttcaaggc tgagaggcgg     2580

gattccaggg atgttgatga agagaaggag ctgctggatt ttgtgccgaa gctagaccaa     2640

gtggtggaat ctccagccat ccccaggatt ccctgtgcca tgcctgagac agtggtgatc     2700

aggtcagaag agcaggagca ggcatctaaa gagtatgatg aggactccct catccccagc     2760

agcccggcca ccgagacctc agacaacatc agcccggtgg ccagcccggt gcatacaggg     2820

tttctggtga gcttcatggt tgacgcccgg ggtggttcca tgagaggaag tcgccacaac     2880

ggcctgcgag tggtgatccc gccacggacg tgcgcagcgc ccacccgcat cacctgccgc     2940

ctggtcaagc cccagaagct cagcacgccg cccccactgg ccgaggagga gggcctggcc     3000

agcaggatca tagcactggg gcccacgggg gcacagttcc tgagccctgt aatcgtggag     3060

atcccgcact ttgcctccca tggccgtgga gaccgcgagc tcgtggttct gaggagcgaa     3120

aacggctccg tgtggaagga gcacaggagc cgctatggag agagctacct ggatcagatc     3180

ctcaacggga tggacgaaga gctggggagc ctggaggagc tagagaagaa gagggtgtgc     3240

cgaatcatca ccaccgactt cccgctgtac ttcgtgatca tgtcacggct ctgccaggac     3300

tacgacacca tcggtcccga agggggctcc ctgaagagca agctggtgcc cctggtacag     3360

gcaacgttcc cggagaatgc cgtcaccaag agagtgaagc tggctctgca ggcccagcct     3420

gtcccggatg agcttgtcac taagctcctg ggcaaccagg ccacattcag ccccattgtc     3480

accgtggagc cccggcgccg gaagttccac cgccccattg ggcttcggat cccactacct     3540

ccttcctgga ccgacaaccc gagggacagc ggggagggag acaccaccag cctgcgcctg     3600

ctttgcagcg tcattggagg aacagaccaa gcccagtggg aagacataac aggaaccacc     3660

aaacttgtat atgccaacga gtgcgccaac ttcaccacca atgtctctgc caggttttgg     3720

ctgtcggact gtcctcggac tgctgaggct gtgaactttg ccaccctgct gtacaaagag     3780

ctcactgcag tgccctacat ggccaaattc gtcatctttg ccaagatgaa tgacccccga     3840

gaggggcgcc tgcgctgcta ctgcatgaca gatgataaag tggacaagac cctggagcag     3900

catgagaact tcgtggaggt ggcccggagc agggacatag aggtgttgga aggaatgtcc     3960

ctgtttgcag aactctctgg gaacctggtg cctgtgaaga aagctgccca gcagcggagc     4020

ttccacttcc agtcatttcg ggagaaccgt ctggccatgc ctgtaaaggt gagggacagc     4080

agtcgagagc cgggagggtc cctgtcgttt ctgcgcaagg cgatgaagta cgaggacacc     4140

cagcacattc tctgccacct gaacatcacc atgcccccct gcgccaaggg aagtggagcc     4200

gaagatagga gaaggacccc gacgcccctg gccctgcgat acagcattct cagtgagtcc     4260

acaccaggtt ctctcagtgg gacagagcag gcagagatga agatggctgt tatctcagag     4320

cacctcggtc tcagctgggc agagttggcc cgggagctgc agttcagtgt ggaagacatc     4380

aacaggatcc gagtggaaaa tcccaactcc ctgttggagc agagtgtggc cttgctgaac     4440

ctctgggtca tccgtgaagg ccaaaacgca aacatggaga atctgtacac agccctgcag     4500

agcattgacc gtggcgagat cgtgaacatg ctggagggtt ccggccgaca gagccgcaac     4560

ttgaagccag acaggcggca caccgaccgc gactactcgc tgtcaccctc ccagatgaat     4620

ggttactcct cactgcagga cgagctgctg tcccctgcct ccctgggctg tgcactttcc     4680

tctccgctac gtgcagacca gtactggaat gaggtggccg tcctagacgc catccccttg     4740

gcggccacgg agcatgacac catgctggag atgtctgaca tgcaggtgtg gtctgcgggc     4800

ctcacgcctt ctctggtcac tgctgaggac tcctctctgg agtgtagcaa ggctgaggac     4860

tctgatgcca caggtcacga gtggaagttg gagggggcac tctcagagga accgcggggc     4920

cccgagttgg gctctctgga acttgtggag gacgacacag tggattcaga tgccacaaat     4980

ggccttatcg atttgcttga acaggaggaa ggtcagaggt cagaagagaa gctgccaggt     5040

tctaagaggc aggatgacgc gacaggtgca gggcaggact cagagaatga agtgtctctt     5100

gtttcaggcc atcagagggg gcaagcccga atcacacatt cccccaccgt gagtcaggtg     5160

acggagagga gtcaggacag actgcaggac tgggatgcag acggctcgat tgtctcatac     5220

ctgcaagatg ctgcacaagg ttcctggcaa gaggaggtca cgcaaggtcc acactcattc     5280

cagggaacaa gtaccatgac tgaagggcta gagcccggtg gatctcagga gtacgagaag     5340

gtcctggtgt ctgtaagtga gcacacgtgg acagaacagc ccgaggctga gagctcccag     5400

gccgacaggg accggaggca gcaaggccaa gaagagcagg tgcaggaggc caagaacacc     5460

ttcacccaag tggtgcaggg gaatgagttt cagaatattc caggggagca ggtgacagag     5520

gagcaattca cggatgagca gggcaacatt gtcaccaaga agatcattcg caaggtggtt     5580

cgacagatag acttgtccag cgccgatgcc gcccaggagc acgaggaggt ggagctgaga     5640

gggagtggcc tacagccgga cctgatagag ggcaggaagg gggcgcagat agtgaagcgg     5700

gccagcctga aaagggggaa acagtgaccc cgagccgctc tccttggagt agcctctcgg     5760

gaggatcaca cctcgacacc caacccctga accccacaca ctctgccatg cacacaggag     5820

gagagctgga cctgagggcc accgcagcgg tgcacacatt cctctgggct gacggcatga     5880

cctctgtaag ggactcctgc tagtcccctc ttggcatgaa tgactgactg tagacgcatg     5940

acctccaggc ttcaatcctg cctcttgcaa tgacagctga tctgtcggaa ccaggacaca     6000

aaagcagcaa gaagcgggga gagagaggga tagaaaacaa gcgcaggaga gcctgcgaac     6060

gcaaaagtga atgagggctt tttgtggctg gggatgggtt ttggttttgg ggtttttttt     6120

ttaaattgtt ttgacttcgt acagggtact ttttcccaac ctcatctgtc agaaatccat     6180

gtgggcttcc tggaaagaaa aaaaaaaaaa agaaaactag gcatgaaatc agtttaacac     6240

cttaatctta agccatgtcc tcatctgccc accctcccca acccacatac ctccattcca     6300

cttgtgacac cccctcgact ccctggtgac gctcctccca gatcgctcta catgacattc     6360

aggacacaca cacacacaca cacacaccac tcgcctccac tgaatctaca cacagatttt     6420

actgtgactt ctgaagctgt atagactctg ctgtggataa attggaattt tttatgttgt     6480

ctctctctct gccaatttca atacgaatca tcttccaatg gaaaatcatt accttgaaga     6540

gtgcattcgg ggttccttgt gttagggact taagaatctg aggcgaggac ccccaggctt     6600

acctgtagga ctcaaaggga gccaggaccc catctgaaag ggtctcctct ctcagttggg     6660

ggacaggccg gtggctgacc caggattgca ccagcatgtc catagagaag aggttttcta     6720

tgtcttcaag cactatatca tagtccgtgt tcaaagtgta aactgtacag taatcagcct     6780

tgtgtatatg aaaaacaata aatactatgc aaaccaatag aaacatttag cagtacgtac     6840

agagcctgac agcgcagctc ctgaggactt ctgcggctgc aggagaagga gctgtggcct     6900

gtctttcagt gaaagaggaa ggaaaggagt agggctagtg aatgtatctg ccaggtctta     6960

gaagtcagga ccacccaggg tctcccagag tgaacttggt gctctaagtc caggcagcct     7020

gcaggctggg gaccctgggt gcaggtgcca ggctcgaggc tgttccctgt cctgcctcag     7080

tgcctcccct ctgcccagcc cctgtggcct cttggagagg cgagccaggg ggctccccgg     7140

accgcatggc cggtgagagt agagtcggag gcggagagcc tggacgccca gaggccgggg     7200

ccaggctctg ggtcaaggca ggaaggagac agacagctgg cagttcctcg cctcggtgcc     7260

atcagggagg agccttaagt tccactagag cctccggccc agggaggcca gaatcagcac     7320

aatcccggcc ccgccctcgc ggcgggcgcc cccagggcca ggagagagag acagggctgg     7380

ctcctctcgc ccctggagcc gcggtgtgga cggcccggcc ccgtccgccc cgccgctctg     7440

cgggagtgtc ctcgggacac acttaaacct tccaagtagc acagaagccc cctccacgtc     7500

agaggccccc tggccgcggg gcctgtgagc ggagaggggc cctgcttccc acacaaatcc     7560

gccccggtgc acccccggcc aggcaggccc cggggcggcc taggcgcctt gtcggccggg     7620

ggtggggctg cttttgcttc ctttagaggg gcgggcaggg agaggaagct ctagctccgg     7680

gcctgagttt ccccgaggct gcgtcggagg agctgcaggg cgagcccgga cggctgccgt     7740

ctccgccaga ggccaccccg gcccggcctc cagggcgcag aggcgccccc ctccatcctc     7800

ccccatcccg ggggccacgg caggggggcc gcacagcgcg gctgggaccg attcggtgac     7860

ggcccaagga agctgggctc agggctcgcc tctcccgcct cgatcctgca ccttcctctc     7920

ccaggtcgct gctgcagcca acccagtagc ccccttagcg cccccgcgga ccccgcagct     7980

ccagactccg ctttggcacc tctgctccgg ctggcatggc tgcacgctcc ggctgctagt     8040

aggagccgtt aggggaggag tttggggtct ccacacgatg cctagagaat gctgcagtct     8100

gcacattaga cgctttttag aagttttgaa attaccttga tttttttaat tgttatgaaa     8160

atggatcttt tcttgactct cccacatgct ctgttatggg agagaatccc ctaccctact     8220

ctgatgtata gaccattctc ccttcaccag ccgaaccaat gtcaaaatta ataaagaaat     8280

ggactaatgg caaaaaaaaa                                                 8300


<210> 3
<211> 1881
<212> PRT
<213> Homo sapiens


<400> 3
Met Pro Tyr Ser Val Gly Phe Arg Glu Ala Asp Ala Ala Thr Ser Phe 
1               5                   10                  15      
Leu Arg Ala Ala Arg Ser Gly Asn Leu Asp Lys Ala Leu Asp His Leu 
            20                  25                  30          
Arg Asn Gly Val Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu Asn Gly 
        35                  40                  45              
Leu His Leu Ala Ser Lys Glu Gly His Val Lys Met Val Val Glu Leu 
    50                  55                  60                  
Leu His Lys Glu Ile Ile Leu Glu Thr Thr Thr Lys Lys Gly Asn Thr 
65                  70                  75                  80  
Ala Leu His Ile Ala Ala Leu Ala Gly Gln Asp Glu Val Val Arg Glu 
                85                  90                  95      
Leu Val Asn Tyr Gly Ala Asn Val Asn Ala Gln Ser Gln Lys Gly Phe 
            100                 105                 110         
Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Leu Glu Val Val Lys 
        115                 120                 125             
Phe Leu Leu Glu Asn Gly Ala Asn Gln Asn Val Ala Thr Glu Asp Gly 
    130                 135                 140                 
Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Glu Asn Val Val 
145                 150                 155                 160 
Ala His Leu Ile Asn Tyr Gly Thr Lys Gly Lys Val Arg Leu Pro Ala 
                165                 170                 175     
Leu His Ile Ala Ala Arg Asn Asp Asp Thr Arg Thr Ala Ala Val Leu 
            180                 185                 190         
Leu Gln Asn Asp Pro Asn Pro Asp Val Leu Ser Lys Thr Gly Phe Thr 
        195                 200                 205             
Pro Leu His Ile Ala Ala His Tyr Glu Asn Leu Asn Val Ala Gln Leu 
    210                 215                 220                 
Leu Leu Asn Arg Gly Ala Ser Val Asn Phe Thr Pro Gln Asn Gly Ile 
225                 230                 235                 240 
Thr Pro Leu His Ile Ala Ser Arg Arg Gly Asn Val Ile Met Val Arg 
                245                 250                 255     
Leu Leu Leu Asp Arg Gly Ala Gln Ile Glu Thr Lys Thr Lys Asp Glu 
            260                 265                 270         
Leu Thr Pro Leu His Cys Ala Ala Arg Asn Gly His Val Arg Ile Ser 
        275                 280                 285             
Glu Ile Leu Leu Asp His Gly Ala Pro Ile Gln Ala Lys Thr Lys Asn 
    290                 295                 300                 
Gly Leu Ser Pro Ile His Met Ala Ala Gln Gly Asp His Leu Asp Cys 
305                 310                 315                 320 
Val Arg Leu Leu Leu Gln Tyr Asp Ala Glu Ile Asp Asp Ile Thr Leu 
                325                 330                 335     
Asp His Leu Thr Pro Leu His Val Ala Ala His Cys Gly His His Arg 
            340                 345                 350         
Val Ala Lys Val Leu Leu Asp Lys Gly Ala Lys Pro Asn Ser Arg Ala 
        355                 360                 365             
Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys Lys Asn His Val 
    370                 375                 380                 
Arg Val Met Glu Leu Leu Leu Lys Thr Gly Ala Ser Ile Asp Ala Val 
385                 390                 395                 400 
Thr Glu Ser Gly Leu Thr Pro Leu His Val Ala Ser Phe Met Gly His 
                405                 410                 415     
Leu Pro Ile Val Lys Asn Leu Leu Gln Arg Gly Ala Ser Pro Asn Val 
            420                 425                 430         
Ser Asn Val Lys Val Glu Thr Pro Leu His Met Ala Ala Arg Ala Gly 
        435                 440                 445             
His Thr Glu Val Ala Lys Tyr Leu Leu Gln Asn Lys Ala Lys Val Asn 
    450                 455                 460                 
Ala Lys Ala Lys Asp Asp Gln Thr Pro Leu His Cys Ala Ala Arg Ile 
465                 470                 475                 480 
Gly His Thr Asn Met Val Lys Leu Leu Leu Glu Asn Asn Ala Asn Pro 
                485                 490                 495     
Asn Leu Ala Thr Thr Ala Gly His Thr Pro Leu His Ile Ala Ala Arg 
            500                 505                 510         
Glu Gly His Val Glu Thr Val Leu Ala Leu Leu Glu Lys Glu Ala Ser 
        515                 520                 525             
Gln Ala Cys Met Thr Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala 
    530                 535                 540                 
Lys Tyr Gly Lys Val Arg Val Ala Glu Leu Leu Leu Glu Arg Asp Ala 
545                 550                 555                 560 
His Pro Asn Ala Ala Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala 
                565                 570                 575     
Val His His Asn Asn Leu Asp Ile Val Lys Leu Leu Leu Pro Arg Gly 
            580                 585                 590         
Gly Ser Pro His Ser Pro Ala Trp Asn Gly Tyr Thr Pro Leu His Ile 
        595                 600                 605             
Ala Ala Lys Gln Asn Gln Val Glu Val Ala Arg Ser Leu Leu Gln Tyr 
    610                 615                 620                 
Gly Gly Ser Ala Asn Ala Glu Ser Val Gln Gly Val Thr Pro Leu His 
625                 630                 635                 640 
Leu Ala Ala Gln Glu Gly His Ala Glu Met Val Ala Leu Leu Leu Ser 
                645                 650                 655     
Lys Gln Ala Asn Gly Asn Leu Gly Asn Lys Ser Gly Leu Thr Pro Leu 
            660                 665                 670         
His Leu Val Ala Gln Glu Gly His Val Pro Val Ala Asp Val Leu Ile 
        675                 680                 685             
Lys His Gly Val Met Val Asp Ala Thr Thr Arg Met Gly Tyr Thr Pro 
    690                 695                 700                 
Leu His Val Ala Ser His Tyr Gly Asn Ile Lys Leu Val Lys Phe Leu 
705                 710                 715                 720 
Leu Gln His Gln Ala Asp Val Asn Ala Lys Thr Lys Leu Gly Tyr Ser 
                725                 730                 735     
Pro Leu His Gln Ala Ala Gln Gln Gly His Thr Asp Ile Val Thr Leu 
            740                 745                 750         
Leu Leu Lys Asn Gly Ala Ser Pro Asn Glu Val Ser Ser Asp Gly Thr 
        755                 760                 765             
Thr Pro Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile Ser Val Thr Asp 
    770                 775                 780                 
Val Leu Lys Val Val Thr Asp Glu Thr Ser Phe Val Leu Val Ser Asp 
785                 790                 795                 800 
Lys His Arg Met Ser Phe Pro Glu Thr Val Asp Glu Ile Leu Asp Val 
                805                 810                 815     
Ser Glu Asp Glu Gly Glu Glu Leu Ile Ser Phe Lys Ala Glu Arg Arg 
            820                 825                 830         
Asp Ser Arg Asp Val Asp Glu Glu Lys Glu Leu Leu Asp Phe Val Pro 
        835                 840                 845             
Lys Leu Asp Gln Val Val Glu Ser Pro Ala Ile Pro Arg Ile Pro Cys 
    850                 855                 860                 
Ala Met Pro Glu Thr Val Val Ile Arg Ser Glu Glu Gln Glu Gln Ala 
865                 870                 875                 880 
Ser Lys Glu Tyr Asp Glu Asp Ser Leu Ile Pro Ser Ser Pro Ala Thr 
                885                 890                 895     
Glu Thr Ser Asp Asn Ile Ser Pro Val Ala Ser Pro Val His Thr Gly 
            900                 905                 910         
Phe Leu Val Ser Phe Met Val Asp Ala Arg Gly Gly Ser Met Arg Gly 
        915                 920                 925             
Ser Arg His Asn Gly Leu Arg Val Val Ile Pro Pro Arg Thr Cys Ala 
    930                 935                 940                 
Ala Pro Thr Arg Ile Thr Cys Arg Leu Val Lys Pro Gln Lys Leu Ser 
945                 950                 955                 960 
Thr Pro Pro Pro Leu Ala Glu Glu Glu Gly Leu Ala Ser Arg Ile Ile 
                965                 970                 975     
Ala Leu Gly Pro Thr Gly Ala Gln Phe Leu Ser Pro Val Ile Val Glu 
            980                 985                 990         
Ile Pro His Phe Ala Ser His Gly Arg Gly Asp Arg Glu Leu Val Val 
        995                 1000                1005            
Leu Arg Ser Glu Asn Gly Ser Val Trp Lys Glu His Arg Ser Arg Tyr 
    1010                1015                1020                
Gly Glu Ser Tyr Leu Asp Gln Ile Leu Asn Gly Met Asp Glu Glu Leu 
1025                1030                1035                1040
Gly Ser Leu Glu Glu Leu Glu Lys Lys Arg Val Cys Arg Ile Ile Thr 
                1045                1050                1055    
Thr Asp Phe Pro Leu Tyr Phe Val Ile Met Ser Arg Leu Cys Gln Asp 
            1060                1065                1070        
Tyr Asp Thr Ile Gly Pro Glu Gly Gly Ser Leu Lys Ser Lys Leu Val 
        1075                1080                1085            
Pro Leu Val Gln Ala Thr Phe Pro Glu Asn Ala Val Thr Lys Arg Val 
    1090                1095                1100                
Lys Leu Ala Leu Gln Ala Gln Pro Val Pro Asp Glu Leu Val Thr Lys 
1105                1110                1115                1120
Leu Leu Gly Asn Gln Ala Thr Phe Ser Pro Ile Val Thr Val Glu Pro 
                1125                1130                1135    
Arg Arg Arg Lys Phe His Arg Pro Ile Gly Leu Arg Ile Pro Leu Pro 
            1140                1145                1150        
Pro Ser Trp Thr Asp Asn Pro Arg Asp Ser Gly Glu Gly Asp Thr Thr 
        1155                1160                1165            
Ser Leu Arg Leu Leu Cys Ser Val Ile Gly Gly Thr Asp Gln Ala Gln 
    1170                1175                1180                
Trp Glu Asp Ile Thr Gly Thr Thr Lys Leu Val Tyr Ala Asn Glu Cys 
1185                1190                1195                1200
Ala Asn Phe Thr Thr Asn Val Ser Ala Arg Phe Trp Leu Ser Asp Cys 
                1205                1210                1215    
Pro Arg Thr Ala Glu Ala Val Asn Phe Ala Thr Leu Leu Tyr Lys Glu 
            1220                1225                1230        
Leu Thr Ala Val Pro Tyr Met Ala Lys Phe Val Ile Phe Ala Lys Met 
        1235                1240                1245            
Asn Asp Pro Arg Glu Gly Arg Leu Arg Cys Tyr Cys Met Thr Asp Asp 
    1250                1255                1260                
Lys Val Asp Lys Thr Leu Glu Gln His Glu Asn Phe Val Glu Val Ala 
1265                1270                1275                1280
Arg Ser Arg Asp Ile Glu Val Leu Glu Gly Met Ser Leu Phe Ala Glu 
                1285                1290                1295    
Leu Ser Gly Asn Leu Val Pro Val Lys Lys Ala Ala Gln Gln Arg Ser 
            1300                1305                1310        
Phe His Phe Gln Ser Phe Arg Glu Asn Arg Leu Ala Met Pro Val Lys 
        1315                1320                1325            
Val Arg Asp Ser Ser Arg Glu Pro Gly Gly Ser Leu Ser Phe Leu Arg 
    1330                1335                1340                
Lys Ala Met Lys Tyr Glu Asp Thr Gln His Ile Leu Cys His Leu Asn 
1345                1350                1355                1360
Ile Thr Met Pro Pro Cys Ala Lys Gly Ser Gly Ala Glu Asp Arg Arg 
                1365                1370                1375    
Arg Thr Pro Thr Pro Leu Ala Leu Arg Tyr Ser Ile Leu Ser Glu Ser 
            1380                1385                1390        
Thr Pro Gly Ser Leu Ser Gly Thr Glu Gln Ala Glu Met Lys Met Ala 
        1395                1400                1405            
Val Ile Ser Glu His Leu Gly Leu Ser Trp Ala Glu Leu Ala Arg Glu 
    1410                1415                1420                
Leu Gln Phe Ser Val Glu Asp Ile Asn Arg Ile Arg Val Glu Asn Pro 
1425                1430                1435                1440
Asn Ser Leu Leu Glu Gln Ser Val Ala Leu Leu Asn Leu Trp Val Ile 
                1445                1450                1455    
Arg Glu Gly Gln Asn Ala Asn Met Glu Asn Leu Tyr Thr Ala Leu Gln 
            1460                1465                1470        
Ser Ile Asp Arg Gly Glu Ile Val Asn Met Leu Glu Gly Ser Gly Arg 
        1475                1480                1485            
Gln Ser Arg Asn Leu Lys Pro Asp Arg Arg His Thr Asp Arg Asp Tyr 
    1490                1495                1500                
Ser Leu Ser Pro Ser Gln Met Asn Gly Tyr Ser Ser Leu Gln Asp Glu 
1505                1510                1515                1520
Leu Leu Ser Pro Ala Ser Leu Gly Cys Ala Leu Ser Ser Pro Leu Arg 
                1525                1530                1535    
Ala Asp Gln Tyr Trp Asn Glu Val Ala Val Leu Asp Ala Ile Pro Leu 
            1540                1545                1550        
Ala Ala Thr Glu His Asp Thr Met Leu Glu Met Ser Asp Met Gln Val 
        1555                1560                1565            
Trp Ser Ala Gly Leu Thr Pro Ser Leu Val Thr Ala Glu Asp Ser Ser 
    1570                1575                1580                
Leu Glu Cys Ser Lys Ala Glu Asp Ser Asp Ala Thr Gly His Glu Trp 
1585                1590                1595                1600
Lys Leu Glu Gly Ala Leu Ser Glu Glu Pro Arg Gly Pro Glu Leu Gly 
                1605                1610                1615    
Ser Leu Glu Leu Val Glu Asp Asp Thr Val Asp Ser Asp Ala Thr Asn 
            1620                1625                1630        
Gly Leu Ile Asp Leu Leu Glu Gln Glu Glu Gly Gln Arg Ser Glu Glu 
        1635                1640                1645            
Lys Leu Pro Gly Ser Lys Arg Gln Asp Asp Ala Thr Gly Ala Gly Gln 
    1650                1655                1660                
Asp Ser Glu Asn Glu Val Ser Leu Val Ser Gly His Gln Arg Gly Gln 
1665                1670                1675                1680
Ala Arg Ile Thr His Ser Pro Thr Val Ser Gln Val Thr Glu Arg Ser 
                1685                1690                1695    
Gln Asp Arg Leu Gln Asp Trp Asp Ala Asp Gly Ser Ile Val Ser Tyr 
            1700                1705                1710        
Leu Gln Asp Ala Ala Gln Gly Ser Trp Gln Glu Glu Val Thr Gln Gly 
        1715                1720                1725            
Pro His Ser Phe Gln Gly Thr Ser Thr Met Thr Glu Gly Leu Glu Pro 
    1730                1735                1740                
Gly Gly Ser Gln Glu Tyr Glu Lys Val Leu Val Ser Val Ser Glu His 
1745                1750                1755                1760
Thr Trp Thr Glu Gln Pro Glu Ala Glu Ser Ser Gln Ala Asp Arg Asp 
                1765                1770                1775    
Arg Arg Gln Gln Gly Gln Glu Glu Gln Val Gln Glu Ala Lys Asn Thr 
            1780                1785                1790        
Phe Thr Gln Val Val Gln Gly Asn Glu Phe Gln Asn Ile Pro Gly Glu 
        1795                1800                1805            
Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn Ile Val Thr 
    1810                1815                1820                
Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu Ser Ser Ala 
1825                1830                1835                1840
Asp Ala Ala Gln Glu His Glu Glu Val Thr Val Glu Gly Pro Leu Glu 
                1845                1850                1855    
Asp Pro Ser Glu Leu Glu Val Asp Ile Asp Tyr Phe Met Lys His Ser 
            1860                1865                1870        
Lys Asp His Thr Ser Thr Pro Asn Pro 
        1875                1880    

<210> 4
<211> 8240
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..8240
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 4
agaggctgcg gtgagtccgc cagccccagc tgctcctcct caagccccca aggcccttcg       60

gcgggcccct gctgaaagac cggcatgccc tattctgtgg gcttccgcga agccgatgct      120

gctaccagct ttctgagagc agcaagatca ggtaacttgg acaaagcttt ggatcacctg      180

cggaatgggg tagatattaa cacctgtaac cagaatgggt tgaatggctt gcatctggct      240

tctaaggaag gccatgtgaa aatggtggtt gaacttctgc acaaagaaat cattctagaa      300

acgacaacca agaaggggaa cacggccctg cacatcgctg ctctagccgg gcaggatgag      360

gtggtccggg agcttgtcaa ctatggagcc aacgtcaacg cccagtcaca gaaaggtttt      420

acacccctgt acatggcagc acaagagaac cacttggaag tggttaagtt tttactggaa      480

aatggagcta accagaatgt agccacagaa gacggcttca cgcctctggc ggtagccctg      540

cagcagggcc atgagaacgt cgtcgcgcac ctcatcaact acggcaccaa ggggaaggtg      600

cgcctcccgg ccctgcacat cgcggcccgc aacgacgaca cgcgcacggc tgcggtgctg      660

ctgcagaacg accccaaccc ggacgtgctt tccaagacgg gattcacgcc cctgcacatt      720

gcggctcact acgagaacct caacgtggcc cagttgctcc tcaacagagg agccagcgtc      780

aatttcacac cacagaacgg catcacgcca ctgcacatcg cctcccgcag gggcaacgtg      840

atcatggtgc ggctgctgct ggatcgggga gcccagatag aaaccaagac caaggacgaa      900

ttgacacctc tccactgtgc agctcgaaat gggcacgtgc gaatctcaga gatcctgctg      960

gaccacgggg caccaatcca agccaaaacc aagaacggcc tgtccccaat tcacatggcg     1020

gctcagggag accacctcga ctgtgtccgg ctcctgttgc aatacgacgc agagatagac     1080

gacatcaccc tggaccacct gaccccactc cacgtggctg cccactgtgg acaccacagg     1140

gtggctaagg tccttctgga taaaggggcc aaacccaact ccagagccct gaatggcttt     1200

acccccttac acatcgcctg caaaaagaac cacgtccgtg tcatggagct gctgctgaag     1260

acgggagcct cgatcgacgc ggtcaccgag tctggcctga cacctctcca cgtggcctcc     1320

ttcatggggc accttcccat cgtgaagaac ctcctgcagc ggggggcgtc gcccaacgtc     1380

tccaacgtga aagtggagac cccgctacac atggcagcca gagccgggca cacggaagtg     1440

gccaaatatt tactccagaa caaagccaaa gtcaatgcca aggccaagga tgaccagacc     1500

ccacttcact gtgcagctcg catcggccac acaaacatgg tgaagctcct gctggaaaat     1560

aacgccaacc ccaacctggc caccaccgcc gggcacaccc ccctgcacat tgcagcccgt     1620

gagggccatg tggaaacagt cctggccctt ctggaaaagg aagcatccca ggcctgcatg     1680

accaagaaag gatttacccc tctgcacgtg gcggccaagt acgggaaggt gcgggtggca     1740

gagctgctgc tggagcggga cgcacacccg aatgctgccg gaaaaaatgg cctgaccccc     1800

ctgcacgtgg ccgtccatca caacaacctg gacatcgtca agctgctgct tccccggggc     1860

ggctccccgc acagccctgc ctggaatggc tacacccctt tgcacatcgc tgccaagcag     1920

aaccaggtgg aggtggcccg tagtctgctg cagtatgggg gctcagcaaa cgccgagtcg     1980

gtgcaaggtg tgacgcccct tcacctggcc gcccaggagg gccacgcaga gatggtggct     2040

ctgctgctct cgaaacaagc caatggcaac ctggggaaca agagcggact cactcccctc     2100

catctggtag cacaagaagg ccacgttcca gtggcagatg tgctgatcaa acacggcgtc     2160

atggtggacg ccaccacccg gatgggctac actcccctcc atgtggccag tcactatgga     2220

aacatcaagc tggtgaagtt tctgctgcag caccaggcag atgtcaatgc caagaccaag     2280

ctaggataca gccccctgca ccaggcagcc cagcagggac acacagacat cgtgactctg     2340

cttctgaaaa acggtgcttc cccaaacgag gtcagctcgg atggaaccac acctctggcc     2400

atagccaagc gcttgggcta catttctgtc accgacgtgc tcaaggtcgt cacggatgaa     2460

accagtttcg tgttagtcag tgataagcat cgaatgagtt tccctgagac agttgatgag     2520

atcctggatg tctcggaaga tgaaggggaa gaactcatca gcttcaaggc tgagaggcgg     2580

gattccaggg atgttgatga agagaaggag ctgctggatt ttgtgccgaa gctagaccaa     2640

gtggtggaat ctccagccat ccccaggatt ccctgtgcca tgcctgagac agtggtgatc     2700

aggtcagaag agcaggagca ggcatctaaa gagtatgatg aggactccct catccccagc     2760

agcccggcca ccgagacctc agacaacatc agcccggtgg ccagcccggt gcatacaggg     2820

tttctggtga gcttcatggt tgacgcccgg ggtggttcca tgagaggaag tcgccacaac     2880

ggcctgcgag tggtgatccc gccacggacg tgcgcagcgc ccacccgcat cacctgccgc     2940

ctggtcaagc cccagaagct cagcacgccg cccccactgg ccgaggagga gggcctggcc     3000

agcaggatca tagcactggg gcccacgggg gcacagttcc tgagccctgt aatcgtggag     3060

atcccgcact ttgcctccca tggccgtgga gaccgcgagc tcgtggttct gaggagcgaa     3120

aacggctccg tgtggaagga gcacaggagc cgctatggag agagctacct ggatcagatc     3180

ctcaacggga tggacgaaga gctggggagc ctggaggagc tagagaagaa gagggtgtgc     3240

cgaatcatca ccaccgactt cccgctgtac ttcgtgatca tgtcacggct ctgccaggac     3300

tacgacacca tcggtcccga agggggctcc ctgaagagca agctggtgcc cctggtacag     3360

gcaacgttcc cggagaatgc cgtcaccaag agagtgaagc tggctctgca ggcccagcct     3420

gtcccggatg agcttgtcac taagctcctg ggcaaccagg ccacattcag ccccattgtc     3480

accgtggagc cccggcgccg gaagttccac cgccccattg ggcttcggat cccactacct     3540

ccttcctgga ccgacaaccc gagggacagc ggggagggag acaccaccag cctgcgcctg     3600

ctttgcagcg tcattggagg aacagaccaa gcccagtggg aagacataac aggaaccacc     3660

aaacttgtat atgccaacga gtgcgccaac ttcaccacca atgtctctgc caggttttgg     3720

ctgtcggact gtcctcggac tgctgaggct gtgaactttg ccaccctgct gtacaaagag     3780

ctcactgcag tgccctacat ggccaaattc gtcatctttg ccaagatgaa tgacccccga     3840

gaggggcgcc tgcgctgcta ctgcatgaca gatgataaag tggacaagac cctggagcag     3900

catgagaact tcgtggaggt ggcccggagc agggacatag aggtgttgga aggaatgtcc     3960

ctgtttgcag aactctctgg gaacctggtg cctgtgaaga aagctgccca gcagcggagc     4020

ttccacttcc agtcatttcg ggagaaccgt ctggccatgc ctgtaaaggt gagggacagc     4080

agtcgagagc cgggagggtc cctgtcgttt ctgcgcaagg cgatgaagta cgaggacacc     4140

cagcacattc tctgccacct gaacatcacc atgcccccct gcgccaaggg aagtggagcc     4200

gaagatagga gaaggacccc gacgcccctg gccctgcgat acagcattct cagtgagtcc     4260

acaccaggtt ctctcagtgg gacagagcag gcagagatga agatggctgt tatctcagag     4320

cacctcggtc tcagctgggc agagttggcc cgggagctgc agttcagtgt ggaagacatc     4380

aacaggatcc gagtggaaaa tcccaactcc ctgttggagc agagtgtggc cttgctgaac     4440

ctctgggtca tccgtgaagg ccaaaacgca aacatggaga atctgtacac agccctgcag     4500

agcattgacc gtggcgagat cgtgaacatg ctggagggtt ccggccgaca gagccgcaac     4560

ttgaagccag acaggcggca caccgaccgc gactactcgc tgtcaccctc ccagatgaat     4620

ggttactcct cactgcagga cgagctgctg tcccctgcct ccctgggctg tgcactttcc     4680

tctccgctac gtgcagacca gtactggaat gaggtggccg tcctagacgc catccccttg     4740

gcggccacgg agcatgacac catgctggag atgtctgaca tgcaggtgtg gtctgcgggc     4800

ctcacgcctt ctctggtcac tgctgaggac tcctctctgg agtgtagcaa ggctgaggac     4860

tctgatgcca caggtcacga gtggaagttg gagggggcac tctcagagga accgcggggc     4920

cccgagttgg gctctctgga acttgtggag gacgacacag tggattcaga tgccacaaat     4980

ggccttatcg atttgcttga acaggaggaa ggtcagaggt cagaagagaa gctgccaggt     5040

tctaagaggc aggatgacgc gacaggtgca gggcaggact cagagaatga agtgtctctt     5100

gtttcaggcc atcagagggg gcaagcccga atcacacatt cccccaccgt gagtcaggtg     5160

acggagagga gtcaggacag actgcaggac tgggatgcag acggctcgat tgtctcatac     5220

ctgcaagatg ctgcacaagg ttcctggcaa gaggaggtca cgcaaggtcc acactcattc     5280

cagggaacaa gtaccatgac tgaagggcta gagcccggtg gatctcagga gtacgagaag     5340

gtcctggtgt ctgtaagtga gcacacgtgg acagaacagc ccgaggctga gagctcccag     5400

gccgacaggg accggaggca gcaaggccaa gaagagcagg tgcaggaggc caagaacacc     5460

ttcacccaag tggtgcaggg gaatgagttt cagaatattc caggggagca ggtgacagag     5520

gagcaattca cggatgagca gggcaacatt gtcaccaaga agatcattcg caaggtggtt     5580

cgacagatag acttgtccag cgccgatgcc gcccaggagc acgaggaggt gactgtagag     5640

gggcccctgg aggatcccag tgagctggag gtcgatattg attactttat gaaacactcc     5700

aaggatcaca cctcgacacc caacccctga accccacaca ctctgccatg cacacaggag     5760

gagagctgga cctgagggcc accgcagcgg tgcacacatt cctctgggct gacggcatga     5820

cctctgtaag ggactcctgc tagtcccctc ttggcatgaa tgactgactg tagacgcatg     5880

acctccaggc ttcaatcctg cctcttgcaa tgacagctga tctgtcggaa ccaggacaca     5940

aaagcagcaa gaagcgggga gagagaggga tagaaaacaa gcgcaggaga gcctgcgaac     6000

gcaaaagtga atgagggctt tttgtggctg gggatgggtt ttggttttgg ggtttttttt     6060

ttaaattgtt ttgacttcgt acagggtact ttttcccaac ctcatctgtc agaaatccat     6120

gtgggcttcc tggaaagaaa aaaaaaaaaa agaaaactag gcatgaaatc agtttaacac     6180

cttaatctta agccatgtcc tcatctgccc accctcccca acccacatac ctccattcca     6240

cttgtgacac cccctcgact ccctggtgac gctcctccca gatcgctcta catgacattc     6300

aggacacaca cacacacaca cacacaccac tcgcctccac tgaatctaca cacagatttt     6360

actgtgactt ctgaagctgt atagactctg ctgtggataa attggaattt tttatgttgt     6420

ctctctctct gccaatttca atacgaatca tcttccaatg gaaaatcatt accttgaaga     6480

gtgcattcgg ggttccttgt gttagggact taagaatctg aggcgaggac ccccaggctt     6540

acctgtagga ctcaaaggga gccaggaccc catctgaaag ggtctcctct ctcagttggg     6600

ggacaggccg gtggctgacc caggattgca ccagcatgtc catagagaag aggttttcta     6660

tgtcttcaag cactatatca tagtccgtgt tcaaagtgta aactgtacag taatcagcct     6720

tgtgtatatg aaaaacaata aatactatgc aaaccaatag aaacatttag cagtacgtac     6780

agagcctgac agcgcagctc ctgaggactt ctgcggctgc aggagaagga gctgtggcct     6840

gtctttcagt gaaagaggaa ggaaaggagt agggctagtg aatgtatctg ccaggtctta     6900

gaagtcagga ccacccaggg tctcccagag tgaacttggt gctctaagtc caggcagcct     6960

gcaggctggg gaccctgggt gcaggtgcca ggctcgaggc tgttccctgt cctgcctcag     7020

tgcctcccct ctgcccagcc cctgtggcct cttggagagg cgagccaggg ggctccccgg     7080

accgcatggc cggtgagagt agagtcggag gcggagagcc tggacgccca gaggccgggg     7140

ccaggctctg ggtcaaggca ggaaggagac agacagctgg cagttcctcg cctcggtgcc     7200

atcagggagg agccttaagt tccactagag cctccggccc agggaggcca gaatcagcac     7260

aatcccggcc ccgccctcgc ggcgggcgcc cccagggcca ggagagagag acagggctgg     7320

ctcctctcgc ccctggagcc gcggtgtgga cggcccggcc ccgtccgccc cgccgctctg     7380

cgggagtgtc ctcgggacac acttaaacct tccaagtagc acagaagccc cctccacgtc     7440

agaggccccc tggccgcggg gcctgtgagc ggagaggggc cctgcttccc acacaaatcc     7500

gccccggtgc acccccggcc aggcaggccc cggggcggcc taggcgcctt gtcggccggg     7560

ggtggggctg cttttgcttc ctttagaggg gcgggcaggg agaggaagct ctagctccgg     7620

gcctgagttt ccccgaggct gcgtcggagg agctgcaggg cgagcccgga cggctgccgt     7680

ctccgccaga ggccaccccg gcccggcctc cagggcgcag aggcgccccc ctccatcctc     7740

ccccatcccg ggggccacgg caggggggcc gcacagcgcg gctgggaccg attcggtgac     7800

ggcccaagga agctgggctc agggctcgcc tctcccgcct cgatcctgca ccttcctctc     7860

ccaggtcgct gctgcagcca acccagtagc ccccttagcg cccccgcgga ccccgcagct     7920

ccagactccg ctttggcacc tctgctccgg ctggcatggc tgcacgctcc ggctgctagt     7980

aggagccgtt aggggaggag tttggggtct ccacacgatg cctagagaat gctgcagtct     8040

gcacattaga cgctttttag aagttttgaa attaccttga tttttttaat tgttatgaaa     8100

atggatcttt tcttgactct cccacatgct ctgttatggg agagaatccc ctaccctact     8160

ctgatgtata gaccattctc ccttcaccag ccgaaccaat gtcaaaatta ataaagaaat     8220

ggactaatgg caaaaaaaaa                                                 8240


<210> 5
<211> 155
<212> PRT
<213> Homo sapiens


<400> 5
Met Trp Thr Phe Val Thr Gln Leu Leu Val Thr Leu Val Leu Leu Ser 
1               5                   10                  15      
Phe Phe Leu Val Ser Cys Gln Asn Val Met His Ile Val Arg Gly Ser 
            20                  25                  30          
Leu Cys Phe Val Leu Lys His Ile His Gln Glu Leu Asp Lys Glu Leu 
        35                  40                  45              
Gly Glu Ser Glu Gly Leu Ser Asp Asp Glu Glu Thr Ile Ser Thr Arg 
    50                  55                  60                  
Val Val Arg Arg Arg Val Phe Leu Lys Gly Asn Glu Phe Gln Asn Ile 
65                  70                  75                  80  
Pro Gly Glu Gln Val Thr Glu Glu Gln Phe Thr Asp Glu Gln Gly Asn 
                85                  90                  95      
Ile Val Thr Lys Lys Ile Ile Arg Lys Val Val Arg Gln Ile Asp Leu 
            100                 105                 110         
Ser Ser Ala Asp Ala Ala Gln Glu His Glu Glu Val Glu Leu Arg Gly 
        115                 120                 125             
Ser Gly Leu Gln Pro Asp Leu Ile Glu Gly Arg Lys Gly Ala Gln Ile 
    130                 135                 140                 
Val Lys Arg Ala Ser Leu Lys Arg Gly Lys Gln 
145                 150                 155 

<210> 6
<211> 3304
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..3304
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 6
gtcacccggg ccactcaggg cagagcctgg ctgctgggca gaagggcact tgggccgggc       60

tgcttcagcc gagagggcca ttcggtgtcc tgcccacaga gagagaaaca gtgagagacc      120

aagagagcaa accagagaga tagggagggg gaatgcaagg ggtccctggg ggactcagga      180

gtcccagtgg agaatgagag gcaggccccc cgtggtggcc ggggccctgg ctgccagagg      240

accgggctgg tgaggaggcg aggatgtgga ctttcgtcac ccagctgttg gtcacgctgg      300

tgctgctgag cttcttcctg gtcagctgtc agaacgtgat gcacattgtc agggggtccc      360

tgtgctttgt gctaaagcac atccaccagg agctggacaa ggagctgggg gagagcgagg      420

gcctcagtga cgacgaggag accatctcca ccagggtggt ccggcggcgg gtcttcctga      480

aggggaatga gtttcagaat attccagggg agcaggtgac agaggagcaa ttcacggatg      540

agcagggcaa cattgtcacc aagaagatca ttcgcaaggt ggttcgacag atagacttgt      600

ccagcgccga tgccgcccag gagcacgagg aggtggagct gagagggagt ggcctacagc      660

cggacctgat agagggcagg aagggggcgc agatagtgaa gcgggccagc ctgaaaaggg      720

ggaaacagtg accccgagcc gctctccttg gagtagcctc tcgggaggat cacacctcga      780

cacccaaccc ctgaacccca cacactctgc catgcacaca ggaggagagc tggacctgag      840

ggccaccgca gcggtgcaca cattcctctg ggctgacggc atgacctctg taagggactc      900

ctgctagtcc cctcttggca tgaatgactg actgtagacg catgacctcc aggcttcaat      960

cctgcctctt gcaatgacag ctgatctgtc ggaaccagga cacaaaagca gcaagaagcg     1020

gggagagaga gggatagaaa acaagcgcag gagagcctgc gaacgcaaaa gtgaatgagg     1080

gctttttgtg gctggggatg ggttttggtt ttggggtttt ttttttaaat tgttttgact     1140

tcgtacaggg tactttttcc caacctcatc tgtcagaaat ccatgtgggc ttcctggaaa     1200

gaaaaaaaaa aaaaagaaaa ctaggcatga aatcagttta acaccttaat cttaagccat     1260

gtcctcatct gcccaccctc cccaacccac atacctccat tccacttgtg acaccccctc     1320

gactccctgg tgacgctcct cccagatcgc tctacatgac attcaggaca cacacacaca     1380

cacacacaca ccactcgcct ccactgaatc tacacacaga ttttactgtg acttctgaag     1440

ctgtatagac tctgctgtgg ataaattgga attttttatg ttgtctctct ctctgccaat     1500

ttcaatacga atcatcttcc aatggaaaat cattaccttg aagagtgcat tcggggttcc     1560

ttgtgttagg gacttaagaa tctgaggcga ggacccccag gcttacctgt aggactcaaa     1620

gggagccagg accccatctg aaagggtctc ctctctcagt tgggggacag gccggtggct     1680

gacccaggat tgcaccagca tgtccataga gaagaggttt tctatgtctt caagcactat     1740

atcatagtcc gtgttcaaag tgtaaactgt acagtaatca gccttgtgta tatgaaaaac     1800

aataaatact atgcaaacca atagaaacat ttagcagtac gtacagagcc tgacagcgca     1860

gctcctgagg acttctgcgg ctgcaggaga aggagctgtg gcctgtcttt cagtgaaaga     1920

ggaaggaaag gagtagggct agtgaatgta tctgccaggt cttagaagtc aggaccaccc     1980

agggtctccc agagtgaact tggtgctcta agtccaggca gcctgcaggc tggggaccct     2040

gggtgcaggt gccaggctcg aggctgttcc ctgtcctgcc tcagtgcctc ccctctgccc     2100

agcccctgtg gcctcttgga gaggcgagcc agggggctcc ccggaccgca tggccggtga     2160

gagtagagtc ggaggcggag agcctggacg cccagaggcc ggggccaggc tctgggtcaa     2220

ggcaggaagg agacagacag ctggcagttc ctcgcctcgg tgccatcagg gaggagcctt     2280

aagttccact agagcctccg gcccagggag gccagaatca gcacaatccc ggccccgccc     2340

tcgcggcggg cgcccccagg gccaggagag agagacaggg ctggctcctc tcgcccctgg     2400

agccgcggtg tggacggccc ggccccgtcc gccccgccgc tctgcgggag tgtcctcggg     2460

acacacttaa accttccaag tagcacagaa gccccctcca cgtcagaggc cccctggccg     2520

cggggcctgt gagcggagag gggccctgct tcccacacaa atccgccccg gtgcaccccc     2580

ggccaggcag gccccggggc ggcctaggcg ccttgtcggc cgggggtggg gctgcttttg     2640

cttcctttag aggggcgggc agggagagga agctctagct ccgggcctga gtttccccga     2700

ggctgcgtcg gaggagctgc agggcgagcc cggacggctg ccgtctccgc cagaggccac     2760

cccggcccgg cctccagggc gcagaggcgc ccccctccat cctcccccat cccgggggcc     2820

acggcagggg ggccgcacag cgcggctggg accgattcgg tgacggccca aggaagctgg     2880

gctcagggct cgcctctccc gcctcgatcc tgcaccttcc tctcccaggt cgctgctgca     2940

gccaacccag tagccccctt agcgcccccg cggaccccgc agctccagac tccgctttgg     3000

cacctctgct ccggctggca tggctgcacg ctccggctgc tagtaggagc cgttagggga     3060

ggagtttggg gtctccacac gatgcctaga gaatgctgca gtctgcacat tagacgcttt     3120

ttagaagttt tgaaattacc ttgatttttt taattgttat gaaaatggat cttttcttga     3180

ctctcccaca tgctctgtta tgggagagaa tcccctaccc tactctgatg tatagaccat     3240

tctcccttca ccagccgaac caatgtcaaa attaataaag aaatggacta atggcaaaaa     3300

aaaa                                                                  3304


