                         SEQUENCE LISTING

<110>  Boehringer Ingelheim RCV GmbH & Co KG
       Lonza Ltd.
       VTU Technology GmbH
       Biomin Holding GmbH
       Sandoz AG
 
<120>  RECOMBINANT HOST CELL WITH ALTERED MEMBRANE LIPID COMPOSITION

<130>  BOE15238PCT

<160>  103   

<170>  PatentIn version 3.5

<210>  1
<211>  330
<212>  PRT
<213>  Pichia pastoris

<400>  1

Met Ser Asp Ile Asn Thr Leu Ser Gln Lys Ile Pro Ser Tyr Val Gln 
1               5                   10                  15      


Tyr Gly Ile Pro Ser Ile Asp His Pro Phe Gly Ile Arg Leu Trp Pro 
            20                  25                  30          


Ile Phe Ser His Phe Phe Glu Ala Val Val Gly Tyr Pro Ala Glu Asp 
        35                  40                  45              


Phe Arg Phe Ile Gln Gly Leu Thr Thr Met Ala Asn Leu Lys Asp Ala 
    50                  55                  60                  


Leu Gly Val Ile Ala Val Tyr Tyr Phe Val Ile Phe Gly Gly Gln Trp 
65                  70                  75                  80  


Leu Met Arg Thr Leu Asn Ala Arg Pro Phe Lys Leu Asn Phe Leu Phe 
                85                  90                  95      


Gln Leu His Asn Leu Val Leu Thr Gly Ala Ser Phe Thr Leu Leu Ile 
            100                 105                 110         


Leu Ile Val Glu Gln Leu Ile Pro Gly Ile Tyr Arg His Gly Ile Phe 
        115                 120                 125             


Trp Ala Ile Cys His Lys Asp Ser Phe Thr Asn Glu Leu Val Thr Leu 
    130                 135                 140                 


Tyr Tyr Leu Asn Tyr Leu Ile Lys Tyr Val Glu Leu Ile Asp Thr Val 
145                 150                 155                 160 


Phe Leu Val Leu Lys Arg Lys Lys Leu Leu Phe Leu His Thr Tyr His 
                165                 170                 175     


His Gly Ala Thr Ala Leu Leu Cys Tyr Thr Gln Leu Leu Gly His Thr 
            180                 185                 190         


Ala Val Glu Trp Val Pro Ile Ala Leu Asn Leu Ala Val His Val Val 
        195                 200                 205             


Leu Tyr Trp Tyr Tyr Phe Leu Ser Ala Arg Gly Ile Arg Val Trp Trp 
    210                 215                 220                 


Lys Gln Trp Val Thr Arg Phe Gln Ile Ile Gln Phe Leu Ile Asp Leu 
225                 230                 235                 240 


Gly Phe Val Tyr Phe Ala Thr Tyr Thr Phe Tyr Ala Asp Lys Tyr Phe 
                245                 250                 255     


Pro Glu Leu Pro Asn Met Gly Thr Cys Tyr Gly Thr Glu Glu Ala Ala 
            260                 265                 270         


Ala Phe Gly Tyr Leu Ile Leu Thr Ser Tyr Leu Val Leu Phe Ile Leu 
        275                 280                 285             


Phe Tyr Ile Arg Val Tyr Lys Ser Gly Pro Thr Thr Ser Lys Gly Lys 
    290                 295                 300                 


Ser Lys Ala Ala Ala Thr Thr Gly Gln Lys Thr Glu Thr Ala Ser Pro 
305                 310                 315                 320 


Ser Gly Lys Ser Thr Ser Val Arg Arg Ala 
                325                 330 


<210>  2
<211>  334
<212>  PRT
<213>  Pichia pastoris

<400>  2

Met Ser Ile Leu Ser Phe Asp Lys Pro Phe Gly Ile Glu Leu Trp Pro 
1               5                   10                  15      


Ile Phe Asp Thr Phe Ala Ser Lys Ala Thr His Gly Ala Phe Val Pro 
            20                  25                  30          


Ser Glu Phe Glu Phe Val Ala Gly Lys Leu Pro Leu Ser Thr Leu Glu 
        35                  40                  45              


Pro Val Leu Tyr Ser Ile Ala Ala Tyr Tyr Phe Ile Val Phe Gly Gly 
    50                  55                  60                  


Tyr Tyr Phe Ile Lys Lys Leu Glu Leu Lys Pro Leu Val Leu Asn Ala 
65                  70                  75                  80  


Leu Phe Ser Ala His Asn Leu Phe Leu Thr Thr Ala Ser Leu Val Leu 
                85                  90                  95      


Leu Thr Leu Met Val Glu Gln Leu Val Pro Ile Ile Tyr His His Gly 
            100                 105                 110         


Leu Phe Tyr Ala Ile Cys Asn Thr Arg Ala Trp Thr Gln Glu Leu Val 
        115                 120                 125             


Thr Leu Tyr Tyr Leu Asn Tyr Leu Ile Lys Phe Val Glu Phe Ile Asp 
    130                 135                 140                 


Thr Phe Phe Leu Val Val Lys Gln Lys Lys Leu Thr Phe Leu His Thr 
145                 150                 155                 160 


Tyr His His Gly Ala Thr Ala Leu Leu Cys Tyr Thr Gln Leu Val Gly 
                165                 170                 175     


Val Thr Ser Ile Ser Trp Val Pro Ile Ser Leu Asn Leu Gly Val His 
            180                 185                 190         


Val Val Met Tyr Trp Tyr Tyr Phe Leu Ala Ser Arg Gly Ile Arg Val 
        195                 200                 205             


Trp Trp Lys Glu Trp Val Thr Arg Phe Gln Ile Met Gln Phe Ile Leu 
    210                 215                 220                 


Asp Leu Gly Phe Val Tyr Phe Ala Ser Tyr Gln Lys Phe Ala Tyr Thr 
225                 230                 235                 240 


Tyr Phe Lys Asp Val Leu Pro Tyr Cys Gly Asp Cys Ala Gly Thr Met 
                245                 250                 255     


Val Ala Ala Val Ser Gly Cys Ala Ile Leu Ser Ser Tyr Leu Val Leu 
            260                 265                 270         


Phe Ile Ala Phe Tyr Ile Glu Val Tyr Arg Lys Gln Gly Lys Lys Ser 
        275                 280                 285             


Arg Tyr Val Lys Lys Val Arg Gly Gly Val Ala Ala Lys Val Asn Glu 
    290                 295                 300                 


Tyr Val Leu Leu Glu Asp Lys Gln Leu Ala Ser Gly Ala Ser Ser Arg 
305                 310                 315                 320 


Ser Ser Ser Pro Val Thr Arg Asn Leu Arg Ser Arg Lys Ala 
                325                 330                 


<210>  3
<211>  403
<212>  PRT
<213>  Pichia pastoris

<400>  3

Met Ser Lys Glu Glu Lys Thr Arg Arg Arg Arg Ala Ser Ser Ile Gly 
1               5                   10                  15      


Asn Ile Asn Leu Gly Asp Asn Ala Val Pro Ser Leu Thr Thr Arg Lys 
            20                  25                  30          


Ser Asn Ala Gln Gln Arg Lys Ser Ser Ser Ala Arg Ile Asn Leu Ile 
        35                  40                  45              


Asn Lys Lys Gly Ser Ser Asp Trp Gly Leu Val Lys Lys Ile Gly Leu 
    50                  55                  60                  


Ser Leu Val Glu Leu Ser Ser Arg His Thr Trp Leu Pro Phe Leu Val 
65                  70                  75                  80  


Ser Leu Val Ala Ile His Gly Ser Tyr Leu Leu Ser Asn Asn His Thr 
                85                  90                  95      


Pro Ser Asn Pro Leu His Lys Phe Val Asp Leu Ser Tyr Lys Ile Glu 
            100                 105                 110         


Gly Thr Asn Pro Pro Met Tyr Gly Lys Gly Trp Lys Asp Phe Cys Phe 
        115                 120                 125             


Val Phe Tyr Phe Met Ile Phe Phe Ser Phe Tyr Arg Glu Phe Leu Met 
    130                 135                 140                 


Gln Ala Leu Leu Lys Pro Leu Ala Ser Lys Leu Gly Ile Thr Arg Glu 
145                 150                 155                 160 


Ser Lys Val Arg Arg Phe Met Glu Gln Ser Tyr Ser Met Cys Tyr Tyr 
                165                 170                 175     


Gly Phe Ser Gly Pro Leu Gly Leu Tyr Ile Met Ala Gly Met Pro Leu 
            180                 185                 190         


Trp Tyr Phe Asn Thr Thr Glu Phe Tyr Ile Thr Tyr Pro His Lys Ser 
        195                 200                 205             


His Glu Tyr Leu Phe Lys Tyr Tyr Tyr Leu Gly Gln Ala Ala Phe Trp 
    210                 215                 220                 


Ser Gln Gln Ala Val Val Leu Met Leu Gln Leu Glu Lys Pro Arg Lys 
225                 230                 235                 240 


Asp Phe Lys Glu Leu Val Ile His His Ile Ile Thr Ile Ala Leu Ile 
                245                 250                 255     


Tyr Cys Ser Tyr Arg Phe His Phe Thr Trp Met Gly Leu Ala Val Tyr 
            260                 265                 270         


Ile Thr Met Asp Ile Ser Asp Phe Phe Leu Ala Leu Ser Lys Thr Leu 
        275                 280                 285             


Asn Tyr Val Asp Ser Ala Tyr Thr Gly Pro Ala Phe Met Phe Phe Val 
    290                 295                 300                 


Gly Val Trp Phe Tyr Leu Arg His Trp Leu Asn Val Lys Ile Leu Trp 
305                 310                 315                 320 


Ser Val Leu Thr Glu Phe Arg Thr Val Gly Pro Phe Glu Leu Asn Trp 
                325                 330                 335     


Ile Thr Gln Gln Tyr Lys Cys Trp Ile Ser Gln Pro Ile Val Phe Ser 
            340                 345                 350         


Leu Ile Phe Ala Leu Gln Leu Val Asn Leu Tyr Trp Phe Val Leu Ile 
        355                 360                 365             


Leu Arg Ile Leu Tyr Arg His Ile Phe Leu Asp Val Thr Lys Asp Glu 
    370                 375                 380                 


Arg Ser Asp Asp Glu Ser Glu Glu Glu Ala Gln Val Glu Pro Ser Lys 
385                 390                 395                 400 


Lys Glu Glu 
            


<210>  4
<211>  378
<212>  PRT
<213>  Pichia pastoris

<400>  4

Met Gly Val Glu Thr Ser Ser Ser Gly Thr Gln His Phe Ser Asp Asp 
1               5                   10                  15      


Gly Cys Val Ser Ser Arg Lys Pro Asn Ala Thr Val Ser Phe Glu Lys 
            20                  25                  30          


Pro Glu Arg Ala Asn Glu Leu Lys Asn His Lys Ile Tyr Lys Lys Ser 
        35                  40                  45              


Lys Ala Ser Trp Leu Gln Arg Asn Gln Ile Leu Leu Ala Ser Ser Leu 
    50                  55                  60                  


Leu Asn Ala Leu Phe Ile Leu Lys Gln Ile Pro Ser Phe Gln Ser Leu 
65                  70                  75                  80  


Val Asn Lys Phe Phe His Leu Gln Tyr Lys Asn Leu Asp Gly Thr Tyr 
                85                  90                  95      


Asp Ile Gly Lys Asp Asp Tyr Phe Phe Val Ile Tyr Trp Ile Ile Asn 
            100                 105                 110         


Leu Thr Ile Ile Arg Ser Val Leu Met Asp Trp Val Leu Glu Pro Leu 
        115                 120                 125             


Ala Ile Lys Ile Val Gly Ile Asn Asn Arg Lys Ala Leu Thr Arg Phe 
    130                 135                 140                 


Lys Glu Gln Gly Trp Ser Leu Phe Tyr Tyr Thr Thr Ser Trp Thr Val 
145                 150                 155                 160 


Gly Phe Tyr Leu Tyr Tyr Lys Ser Asp Tyr Phe Phe Asn Cys Asp His 
                165                 170                 175     


Ile Phe Ile Gly Trp Pro Asn Asn Lys Leu Asp Phe Tyr Phe Lys Ser 
            180                 185                 190         


Tyr Tyr Leu Ile Gln Met Ser Cys Trp Leu Gln Gln Ile Val Val Leu 
        195                 200                 205             


Asn Ile Glu Glu Arg Arg Lys Asp Tyr Val Gln Met Phe Ser His His 
    210                 215                 220                 


Ile Ile Thr Cys Leu Leu Ile Ile Gly Ser Tyr Tyr Tyr Tyr Phe Leu 
225                 230                 235                 240 


Gln Ile Gly His Val Ile Leu Val Met Met Asp Ile Val Asp Val Phe 
                245                 250                 255     


Leu Ser Leu Ala Lys Met Leu Lys Tyr Cys Gly Tyr Ser Thr Leu Cys 
            260                 265                 270         


Asp Val Met Phe Phe Ile Phe Leu Val Ser Trp Ile Ala Ile Arg His 
        275                 280                 285             


Val Cys Tyr Asn Tyr Val Phe Trp His Thr Cys Thr Lys Ser Arg Asp 
    290                 295                 300                 


Leu Met Asn Ala Asp Cys Ser Arg Tyr Ala Ile Tyr Gly Gly Pro Leu 
305                 310                 315                 320 


Asp Val Thr Pro Val Arg Cys Tyr Thr Asp Ser Thr Ile Arg Tyr Phe 
                325                 330                 335     


Ile Phe Leu Leu Gly Gly Leu Gln Ile Ile Thr Leu Ile Trp Met Tyr 
            340                 345                 350         


Leu Ile Leu Lys Val Phe Ile Gly Val Ile Thr Gly Lys Gly Ala Glu 
        355                 360                 365             


Asp Val Arg Ser Asp Asp Glu Glu Ser Ser 
    370                 375             


<210>  5
<211>  396
<212>  PRT
<213>  Pichia pastoris

<400>  5

Met Ser Gln Arg Glu Glu Thr Lys Asp Ala Ala Lys Lys Gln Ile Ala 
1               5                   10                  15      


Phe Ser Gly Ile Gly Ala Cys Gly Pro Pro Asn Phe Tyr Gly Thr Gln 
            20                  25                  30          


Asp Ala His Ala Arg Leu Glu Glu Asp Leu Ala Arg Phe Leu Gly Ala 
        35                  40                  45              


Glu Arg Ala Ile Leu Tyr Ser Gln Asp Phe Cys Thr Val Pro Ser Val 
    50                  55                  60                  


Ile Ala Cys Phe Leu Lys Arg Gly Asp Ile Val Val Tyr Asp Ser Gly 
65                  70                  75                  80  


Ile Ala Leu Ala Thr Gln Lys Gly Ile Glu Leu Ser Arg Cys Thr Ala 
                85                  90                  95      


Tyr His Phe Asn His Asn Asp Met Asp Asn Leu Glu Lys Val Leu Ala 
            100                 105                 110         


Asp Leu Lys Pro Met Leu Asp Glu Gly Pro Leu Thr Arg Arg Phe Ile 
        115                 120                 125             


Ile Thr Glu Gly Leu Phe Gln Asn Phe Gly Asp Ser Pro Asp Leu Arg 
    130                 135                 140                 


Arg Ile Cys Glu Leu Lys Lys Lys Phe Lys Tyr Arg Leu Phe Leu Asp 
145                 150                 155                 160 


Glu Thr Leu Ser Ile Gly Val Leu Gly Ala Thr Gly Arg Gly Leu Pro 
                165                 170                 175     


Glu Leu Tyr Gly Ile Pro Arg Thr Asp Val Glu Val Thr Thr Gly Ala 
            180                 185                 190         


Leu Ser Tyr Ala Leu Gly Ser Ser Gly Gly Phe Cys Val Gly Glu Asn 
        195                 200                 205             


Ala Met Val His His Gln Leu Ile Ser Ser Ser Ala Tyr Val Phe Ser 
    210                 215                 220                 


Ala Ala Ile Pro Pro Tyr Phe Ala Arg Val Ala Ser Val Ser Leu Arg 
225                 230                 235                 240 


Leu Leu Gln Glu Asp Asp Ser Val Ser Arg Leu Gln Ser Ser Ile Asn 
                245                 250                 255     


Phe Leu Tyr Ser Lys Phe Lys Glu Cys Gln Lys Leu Lys Lys Leu Val 
            260                 265                 270         


Ile Ile Thr Ser Ser Asp Val Ser Pro Ile Leu His Leu Arg Leu His 
        275                 280                 285             


Arg Asp Leu Arg Ser Arg Leu Asp Leu Pro Val Ser Tyr Gly Gly Pro 
    290                 295                 300                 


Gly Ser Ala Met Glu Lys Ile Val Gln Arg Gly Asp Glu His Gly Tyr 
305                 310                 315                 320 


Phe Asp Glu Asn Tyr Asn Arg Glu Ser Gln Ile Leu Gln Gln Ile Val 
                325                 330                 335     


Asp Arg Val Leu Asn Asn His Asn Ile Leu Ile Thr Arg Cys Lys Arg 
            340                 345                 350         


Ile Leu His His Glu Lys Leu Pro Leu Leu Pro Glu Leu Met Ile His 
        355                 360                 365             


Ile Asn Val Ala Phe Ser Glu Ser Glu Leu Ser Glu Ala Phe Glu Ala 
    370                 375                 380                 


Val Ser Ser Glu Ile Tyr Asn Val Leu Gln Gln Leu 
385                 390                 395     


<210>  6
<211>  561
<212>  PRT
<213>  Pichia pastoris

<400>  6

Met Ser Lys Thr Ile Pro Asp Ala Leu Ile Asp Asn Asp Ser Pro Gln 
1               5                   10                  15      


Glu Lys Ala Glu Lys Glu Phe Gly Ser Leu Thr Ser Lys Glu Trp Leu 
            20                  25                  30          


Phe Val Ser Lys His Asn Pro Gly Glu Pro Leu Pro Val Pro Ile Glu 
        35                  40                  45              


Asp Glu Pro Pro Tyr Phe Ile Leu Ile Ala Thr Tyr Leu Asn Tyr Leu 
    50                  55                  60                  


Ile Leu Ile Ile Ile Gly His Ile Arg Asp Phe Phe Gly Lys Leu Phe 
65                  70                  75                  80  


His Pro Glu Leu Phe Arg Asp Val Met Val Lys Asp Gly Ile Ala Pro 
                85                  90                  95      


Trp Tyr Ala Asn Phe Glu Ser Phe Tyr Thr Arg Arg Leu Lys Thr Arg 
            100                 105                 110         


Leu Asp Asp Cys Phe Ala Arg Pro Ile Cys Gly Val Pro Gly Arg Tyr 
        115                 120                 125             


Ile Lys Cys Tyr Asp Arg Thr Ser Asp Asp Tyr Asn Asn Thr Tyr Asn 
    130                 135                 140                 


Tyr Ser Gly Thr Val Thr Glu Arg Leu Asn Leu Ser Ser Tyr Asn Tyr 
145                 150                 155                 160 


Leu Gly Phe Ala Gln Ser Ser Gly Leu Cys Thr Ser Glu Ser Ile Lys 
                165                 170                 175     


Thr Val Glu Lys Tyr Gly Thr Asn Ser Ala Gly Pro Arg Val Ser Val 
            180                 185                 190         


Gly Thr Thr Asp Leu His Leu Glu Cys Glu Asp Val Val Ala Lys Phe 
        195                 200                 205             


Thr Gly Lys Asp Asn Ala Leu Val Phe Ser Met Gly Tyr Gly Thr Asn 
    210                 215                 220                 


Ala Asn Leu Phe Thr Ser Leu Val Asp Ser Lys Cys Cys Val Ile Ser 
225                 230                 235                 240 


Asp Ser Leu Asn His Gly Ser Ile Arg Thr Gly Val Arg Leu Ser Gly 
                245                 250                 255     


Ala Ser Val Lys Thr Phe Ala His Asn Asp Met Ala Ala Leu Glu Arg 
            260                 265                 270         


Thr Leu Arg Ser Val Ile Ser Gln Gly Gln Pro Lys Thr His Arg Pro 
        275                 280                 285             


Trp Lys Lys Ile Phe Val Ala Val Glu Gly Leu Tyr Ser Met Glu Gly 
    290                 295                 300                 


Thr Leu Cys Asn Leu Pro Lys Leu Val Glu Leu Arg Lys Arg Tyr Lys 
305                 310                 315                 320 


Phe Tyr Leu Phe Val Asp Glu Ala His Ser Ile Gly Ala Met Gly Pro 
                325                 330                 335     


Asn Gly Lys Gly Val Cys Asp Tyr Phe Gly Ile Ser Ser Ser Asn Ile 
            340                 345                 350         


Asp Ile Met Met Gly Thr Phe Thr Lys Ser Phe Gly Ala Thr Gly Gly 
        355                 360                 365             


Tyr Ile Ala Ala Asp Lys Ala Ile Ile Asp Arg Leu Lys Leu Asp Leu 
    370                 375                 380                 


Thr Thr Asn Thr Tyr Gly Glu Ser Met Ser Pro Ala Val Leu Thr Gln 
385                 390                 395                 400 


Ile Ile Thr Ser Leu Lys Ile Ile Asp Gly Gln Leu Asn Gly Asn Glu 
                405                 410                 415     


Gly Lys Glu Arg Leu Gln Arg Ile Ala Phe Asn Ser Arg Tyr Leu Arg 
            420                 425                 430         


Leu Gly Leu Lys Arg Leu Gly Phe Ile Val Tyr Gly Ala Asp Asp Ser 
        435                 440                 445             


Pro Val Ile Pro Leu Leu Leu Tyr Leu Pro Pro Lys Met Pro Ala Phe 
    450                 455                 460                 


Ser Arg Met Met Tyr Asp Arg Lys Val Ala Val Val Val Val Gly Tyr 
465                 470                 475                 480 


Pro Ala Thr Asp Ile Thr Ser Ser Arg Ile Arg Phe Cys Val Ser Ser 
                485                 490                 495     


Ser Leu Lys Lys Glu Asp Ile Asp Tyr Leu Leu Lys Cys Cys Asp Glu 
            500                 505                 510         


Ile Gly Asp Thr Leu Phe Leu Lys Phe Ser Thr Gly Ile Ala Gly Gly 
        515                 520                 525             


Glu Lys His Pro Gly Asp Tyr Lys Lys Gly Ile Ala Pro Arg Trp Thr 
    530                 535                 540                 


Leu Glu Glu Val Leu Glu Lys Thr Pro Glu Asp Cys Lys Lys Ala Met 
545                 550                 555                 560 


Tyr 
    


<210>  7
<211>  320
<212>  PRT
<213>  Pichia pastoris

<400>  7

Met Val Lys Leu Ile Val Asn Pro Arg Ser Glu Thr Leu Arg Gln Ile 
1               5                   10                  15      


Asn Val Asp Thr Thr Pro Asn Thr Arg Val Arg Asp Ile Val Val Ala 
            20                  25                  30          


Tyr Gly Lys Ala Asn Asn Ser Leu Ser Ser Ser Arg Ile Arg Phe Thr 
        35                  40                  45              


Lys Leu Glu Glu Asp Ala Val Ser Lys Lys Pro Lys His Val Thr Leu 
    50                  55                  60                  


Asp Tyr Glu Lys Ser Leu Ala Gln Asn Gly Ile Val Phe Thr Asp Asp 
65                  70                  75                  80  


Ser Asp Ser Lys Glu Val Tyr Ala Lys Asp Leu Gly Pro Gln Ile Ser 
                85                  90                  95      


Trp Lys Leu Val Phe Leu Ile Glu Tyr Val Gly Pro Leu Ile Ile His 
            100                 105                 110         


Pro Leu Leu Tyr Tyr Gly Trp Phe Lys Pro Asp Tyr Asn Thr Leu Thr 
        115                 120                 125             


Gln Lys Val Ser Phe Ile Leu Val Met Leu His Phe Leu Lys Arg Glu 
    130                 135                 140                 


Tyr Glu Thr Thr Phe Val His Leu Phe Ser Ser Asp Thr Met Pro Leu 
145                 150                 155                 160 


Phe Asn Val Phe Lys Asn Ser Ala His Tyr Trp Ile Leu Ser Gly Leu 
                165                 170                 175     


Ser Leu Ala Val Thr Ile Tyr Ala Pro Asp Ser Tyr Arg Asn Lys Phe 
            180                 185                 190         


Ala Pro Thr Trp Lys Gln Phe Phe Phe His Val Ser Asp His Glu Asp 
        195                 200                 205             


Ser Thr Val Leu Ala Leu Ile Gly Leu Trp Val Phe Ala Glu Leu Ser 
    210                 215                 220                 


Asn Phe Ile Thr His Gln Lys Leu Ala Ser Leu Arg Ala Asp Gly Ser 
225                 230                 235                 240 


Arg Glu His Lys Ile Pro Tyr Gly Tyr Gly Phe Asn Leu Val Ser Phe 
                245                 250                 255     


Pro Asn Tyr Phe Phe Glu Ser Val Ala Trp Leu Ala Phe Ala Leu Leu 
            260                 265                 270         


Asn Asn Asn Trp Ser Ser Trp Val Phe Leu Thr Ile Ala Ser Ile Gln 
        275                 280                 285             


Met Tyr Ile Trp Ala Ala Lys Lys His Lys Arg Tyr Leu Lys Glu Phe 
    290                 295                 300                 


Gly Asp Gln Tyr Pro Lys Asn Arg Lys Ala Met Ile Pro Phe Leu Leu 
305                 310                 315                 320 


<210>  8
<211>  150
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  8

Met Ser Gln Pro Thr Pro Ile Ile Thr Thr Lys Ser Ala Ala Lys Pro 
1               5                   10                  15      


Lys Pro Lys Ile Phe Asn Leu Phe Arg Val Cys Phe Ile Ser Leu Leu 
            20                  25                  30          


Leu Ile Ala Ala Val Glu Tyr Phe Lys Tyr Gly Thr Arg Ile Asn Tyr 
        35                  40                  45              


Glu Trp Phe His Cys Thr Pro Ile Lys Glu Pro Gln Ser Gly Ser Val 
    50                  55                  60                  


Ile Lys Leu Trp Ala Arg Gly Gly Pro Ser Cys Asp Lys Arg Gly Glu 
65                  70                  75                  80  


Tyr Lys Thr Ile Val Lys Arg Ile Thr Arg Asp Tyr Glu Pro Asn Asp 
                85                  90                  95      


Glu His Leu Ser Phe Cys Ile Ile Glu Asn Asp Asn Val Pro Pro Val 
            100                 105                 110         


His Tyr Pro Ile His Glu Asp Lys Gly Glu Pro Gly Tyr Val Ala Tyr 
        115                 120                 125             


Val Gly Tyr Asp Thr Asp Ser Glu Leu Val Gln Glu Leu Cys Ala Asp 
    130                 135                 140                 


Ser Thr Ile Tyr His Met 
145                 150 


<210>  9
<211>  80
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Thr Gln His Lys Ser Ser Met Val Tyr Ile Pro Thr Thr Lys Glu 
1               5                   10                  15      


Ala Lys Arg Arg Asn Gly Lys Ser Glu Gly Ile Leu Asn Thr Ile Glu 
            20                  25                  30          


Glu Val Val Glu Lys Leu Tyr Trp Thr Tyr Tyr Ile His Leu Pro Phe 
        35                  40                  45              


Tyr Leu Met Ala Ser Phe Asp Ser Phe Phe Leu His Val Phe Phe Leu 
    50                  55                  60                  


Thr Ile Phe Ser Leu Ser Phe Phe Gly Ile Leu Lys Tyr Cys Phe Leu 
65                  70                  75                  80  


<210>  10
<211>  775
<212>  PRT
<213>  Pichia pastoris

<400>  10

Met Gln Tyr Val Gly Arg Ala Ile Gly Ser Val Ser Lys Thr Trp Ser 
1               5                   10                  15      


Ser Ile Asn Pro Ala Thr Leu Ser Gly Ala Ile Asp Ile Ile Val Val 
            20                  25                  30          


Glu Gln Glu Asn Gly Asp Leu Ala Cys Ser Pro Phe His Val Arg Phe 
        35                  40                  45              


Gly Lys Phe Gln Leu Leu Arg Pro Ser Gln Lys Lys Val Asp Phe Ile 
    50                  55                  60                  


Val Asn Gly Glu Lys Thr Asp Leu Pro Met Lys Leu Gly Asp Gly Gly 
65                  70                  75                  80  


Glu Ala Phe Phe Val Phe Glu Thr Asp Ala Ala Ile Pro Ser Glu Leu 
                85                  90                  95      


Gln Thr Ser Pro Val Ile Ser Pro Val Ser Ser Pro Glu Pro Ala Ser 
            100                 105                 110         


Pro Leu Ser Thr Pro Ser Arg Pro Asn Ser Glu Pro Asp Tyr Leu Glu 
        115                 120                 125             


Leu Gly Asp Gly Glu Ser Thr Thr Ser Glu Leu Glu Asn Phe Lys Leu 
    130                 135                 140                 


Asn Arg Tyr Pro Tyr Leu Ser Thr Glu Val Ser His Ser Asp Pro Gly 
145                 150                 155                 160 


Val Gly Ser Val Ser Ser Ser Pro Glu Asn Thr Lys Ile Ile Gln Lys 
                165                 170                 175     


Ile Ser Arg Lys Leu Asn Thr Lys Asn Ile Pro Ser Lys Val Asp Asn 
            180                 185                 190         


Asn Gly Asn Leu Val Leu Asp Ile Gln Gly Tyr Lys Ser Asp Asp Leu 
        195                 200                 205             


Asp Asp Asn Ser Lys Ser Leu Lys Gln Leu Leu Leu Ala Glu Leu Gly 
    210                 215                 220                 


Glu Asp Val Asp Leu Asp Lys Val Ile Glu Lys Asp His Glu Gly Asn 
225                 230                 235                 240 


Ile Met Ile Asn Gly Ala Ile Ser Leu Leu Ser Gly Glu Asp Asp Leu 
                245                 250                 255     


Glu Ser Phe Pro Gln Thr Asp Asp Gln Ala Glu Ser Leu Lys Leu Asp 
            260                 265                 270         


Leu Glu Ser Asp Lys Ser Asp Ile Glu Ser Asp Thr Asn His Glu Leu 
        275                 280                 285             


Ser Arg Tyr Phe Lys Thr Leu Arg Leu Thr Ser Asp Gln Leu Lys Cys 
    290                 295                 300                 


Leu Thr Leu Lys Lys Gly Ile Asn Glu Leu Lys Phe Ser Val Asn Lys 
305                 310                 315                 320 


Gly Lys Ser Val Val Thr Ala Asn Leu Tyr Phe Trp Asp Tyr Tyr Asp 
                325                 330                 335     


Pro Ile Val Ile Ser Asp Ile Asp Gly Thr Ile Thr Lys Ser Asp Ala 
            340                 345                 350         


Leu Gly His Val Phe Thr Met Ile Gly Arg Asp Trp Thr His Lys Gly 
        355                 360                 365             


Val Ala Lys Leu Phe Ser Asp Ile Lys Ser Asn Gly Tyr Asn Ile Met 
    370                 375                 380                 


Tyr Leu Thr Ala Arg Ser Val Gly Gln Ala Asp Ser Thr Arg Tyr Tyr 
385                 390                 395                 400 


Leu Asn Asn Ile Glu Gln Glu Gly Leu Arg Leu Pro Gln Gly Pro Val 
                405                 410                 415     


Ile Leu Ser Pro Asp Arg Thr Met Ala Ala Leu Arg Arg Glu Val Ile 
            420                 425                 430         


Leu Lys Lys Pro Glu Val Phe Lys Met Ala Cys Leu Asn Asp Ile Lys 
        435                 440                 445             


Lys Leu Tyr Leu Thr Asn Thr Lys Asp Leu Asn Pro Asn Thr Asp Ser 
    450                 455                 460                 


Ala Asp Phe Thr Asp Ile Asn Thr Asn Thr Leu Arg Ser Ser Ser Leu 
465                 470                 475                 480 


Thr Glu Asp Val Gln Thr Pro Phe Tyr Ala Gly Phe Gly Asn Arg Ile 
                485                 490                 495     


Thr Asp Ala Leu Ser Tyr Arg Ser Val Gly Ile Pro Ser Ser Arg Ile 
            500                 505                 510         


Phe Thr Ile Asn Pro Asp Gly Asp Val His Met Glu Leu Leu Glu Leu 
        515                 520                 525             


Ala Gly Tyr Arg Ser Ser Tyr Val His Ile Ser Glu Leu Val Asp His 
    530                 535                 540                 


Phe Phe Pro Pro Val Asn Thr Glu Leu Phe Lys Ser Met Pro Ser Asp 
545                 550                 555                 560 


Thr Tyr Arg Asn Thr Ala Lys Phe Ser Asp Val Asn Tyr Trp Lys Glu 
                565                 570                 575     


Pro Leu Tyr Asn Phe Glu Glu Leu Ser Asp Glu Asp Ser Ser Glu Asp 
            580                 585                 590         


Glu Leu Arg Arg Arg Lys Glu Glu Glu Arg Leu Gln Ser Ala Pro Arg 
        595                 600                 605             


Ser Pro Ile Leu Ala Ala Gly Ala Ser Phe Phe Lys Gly Ser Ser Ser 
    610                 615                 620                 


Leu Leu Gly Ser Pro Glu Arg Met Thr Leu Ser Asp Pro Lys Pro Thr 
625                 630                 635                 640 


Glu Val Ala Pro Ser Thr Ile Lys Pro Pro Lys Ser Val Gly Ser Val 
                645                 650                 655     


Ser Ser Asp Glu Glu Lys Leu Lys Asp His Asp Asp Phe Ile Asp Val 
            660                 665                 670         


Asp His Glu Asp Glu Thr Leu Asp Asp Asp Asp Asp Pro Phe Asp Tyr 
        675                 680                 685             


Asp Tyr Glu Tyr Glu Asp Glu Glu Glu Glu Asn Asp Asp Val Asp Glu 
    690                 695                 700                 


Val Asp Asp Gly Glu Glu Tyr Ser Asp Asp Tyr Tyr Asp Glu Glu Asp 
705                 710                 715                 720 


Asp Tyr Asp Glu Glu Leu Asp His Thr Leu Glu Pro Asp Gln Lys Lys 
                725                 730                 735     


Glu Leu Asp Gln Thr Ala Glu Ala Asn Gln Leu Pro Pro Ser Gly Pro 
            740                 745                 750         


Asp Glu Met Glu Ser Lys Ser Phe Lys Lys Ala Ser Asp Leu Ile Ser 
        755                 760                 765             


Lys Met Arg Ile Asp Asp Ser 
    770                 775 


<210>  11
<211>  313
<212>  PRT
<213>  Pichia pastoris

<400>  11

Met Lys Leu Ser Thr Asn Leu Ile Leu Ala Ile Ala Ala Ala Ser Ala 
1               5                   10                  15      


Val Val Ser Ala Ala Pro Val Ala Pro Ala Glu Glu Ala Ala Asn His 
            20                  25                  30          


Leu His Lys Arg Ala Tyr Tyr Thr Asp Thr Thr Lys Thr His Thr Phe 
        35                  40                  45              


Thr Glu Val Val Thr Val Tyr Arg Thr Leu Lys Pro Gly Glu Ser Ile 
    50                  55                  60                  


Pro Thr Asp Ser Pro Ser His Gly Gly Lys Ser Thr Lys Lys Gly Lys 
65                  70                  75                  80  


Gly Ser Thr Thr His Ser Gly Ala Pro Gly Ala Thr Ser Gly Ala Pro 
                85                  90                  95      


Thr Asp Asp Thr Thr Ser Thr Ser Gly Ser Val Gly Leu Pro Thr Ser 
            100                 105                 110         


Ala Thr Ser Val Thr Ser Ser Thr Ser Ser Ala Ser Thr Thr Ser Ser 
        115                 120                 125             


Gly Thr Ser Ala Thr Ser Thr Gly Thr Gly Thr Ser Thr Ser Thr Ser 
    130                 135                 140                 


Thr Gly Thr Gly Thr Gly Thr Thr Gly Thr Gly Thr Thr Ser Ser Ser 
145                 150                 155                 160 


Thr Ser Ser Ser Ala Thr Ser Thr Pro Thr Gly Ser Ile Asp Ala Ile 
                165                 170                 175     


Ser Gln Thr Leu Leu Asp Thr His Asn Asp Lys Arg Ala Leu His Gly 
            180                 185                 190         


Val Pro Asp Leu Thr Trp Ser Thr Glu Leu Ala Asp Tyr Ala Gln Gly 
        195                 200                 205             


Tyr Ala Asp Ser Tyr Thr Cys Gly Ser Ser Leu Glu His Thr Gly Gly 
    210                 215                 220                 


Pro Tyr Gly Glu Asn Leu Ala Ser Gly Tyr Ser Pro Ala Gly Ser Val 
225                 230                 235                 240 


Glu Ala Trp Tyr Asn Glu Ile Ser Asp Tyr Asp Phe Ser Asn Pro Gly 
                245                 250                 255     


Tyr Ser Ala Gly Thr Gly His Phe Thr Gln Val Val Trp Lys Ser Thr 
            260                 265                 270         


Thr Gln Leu Gly Cys Gly Tyr Lys Glu Cys Ser Thr Asp Arg Tyr Tyr 
        275                 280                 285             


Ile Ile Cys Glu Tyr Ala Pro Arg Gly Asn Ile Val Ser Ala Gly Tyr 
    290                 295                 300                 


Phe Glu Asp Asn Val Leu Pro Pro Val 
305                 310             


<210>  12
<211>  515
<212>  PRT
<213>  Pichia pastoris

<400>  12

Met Ser Leu Val Gln Glu Leu Ile Gln Lys Ile Ser Ser Leu Glu Leu 
1               5                   10                  15      


Thr Leu Val Glu Lys Leu Ser Ile Leu Phe Val Ala Pro Phe Leu Leu 
            20                  25                  30          


Asn Ala Leu Trp Gln Phe Ile Tyr Ser Phe Arg Lys Asp Arg Val Pro 
        35                  40                  45              


Leu Val Phe His Trp Val Pro Trp Val Gly Ser Ala Val Thr Tyr Gly 
    50                  55                  60                  


Met Gln Pro Tyr Glu Phe Phe Ala Asp Cys Gln Arg Lys Tyr Gly Asp 
65                  70                  75                  80  


Val Phe Ala Phe Val Leu Leu Gly Lys Val Met Thr Val Tyr Leu Gly 
                85                  90                  95      


Pro Lys Gly His Glu Phe Ile Leu Asn Ala Lys Leu Asn Asp Val Cys 
            100                 105                 110         


Ala Glu Asp Ala Tyr Lys His Leu Thr Thr Pro Val Phe Gly Glu Gly 
        115                 120                 125             


Val Ile Tyr Asp Cys Pro Asn Trp Lys Leu Met Asp Gln Lys Lys Phe 
    130                 135                 140                 


Val Lys Gly Ser Leu Thr Lys Glu Ser Phe Arg Ser Tyr Val Pro Lys 
145                 150                 155                 160 


Ile Arg Asp Glu Val Leu Asp Tyr Ile Asn Asn Asp Pro Asn Phe Met 
                165                 170                 175     


Gly Gly Asp Ser Lys Lys Lys Thr Gly Lys Thr Asn Val Leu Asn Ser 
            180                 185                 190         


Gln Ser Glu Leu Thr Ile Leu Thr Ala Ser Arg Ser Leu Leu Gly Asp 
        195                 200                 205             


Asp Met Arg Lys Leu Leu Thr Lys Lys Trp Ala Lys Leu Phe Ser Asp 
    210                 215                 220                 


Leu Asp Lys Gly Phe Thr Pro Leu Asn Phe Ile Phe Ser His Leu Pro 
225                 230                 235                 240 


Leu Pro Ser Tyr Trp Thr Arg Asp His Ala Gln Lys Thr Ile Ser Glu 
                245                 250                 255     


Thr Tyr Leu Ser Leu Ile Asn Lys Arg Arg Ala Thr Asn Asp Ile Gly 
            260                 265                 270         


Asp Arg Asp Leu Ile Asp Ser Leu Met Lys Ser Ser Thr Tyr Lys Asp 
        275                 280                 285             


Gly Ser Lys Met Thr Asp Glu Glu Ile Ser His Leu Leu Ile Gly Val 
    290                 295                 300                 


Leu Met Gly Gly Gln His Thr Ser Ala Ser Thr Ser Ser Trp Phe Leu 
305                 310                 315                 320 


Leu His Leu Gly Glu Lys Pro Glu Leu Gln Glu Glu Leu Phe Glu Glu 
                325                 330                 335     


Gln Glu Arg Val Leu Gln Gly Arg Glu Leu Thr Tyr Asp Asp Leu Ala 
            340                 345                 350         


Asn Met Pro Leu His Asn Gln Val Ile Lys Glu Thr Leu Arg Met His 
        355                 360                 365             


Met Pro Leu His Ser Ile Phe Arg Lys Val Thr Arg Pro Leu Pro Val 
    370                 375                 380                 


Pro Asn Ser Lys Tyr Val Val Pro Lys Gly His Tyr Val Leu Val Ser 
385                 390                 395                 400 


Pro Gly Phe Ala Met Thr Asn Asp Ala Tyr Phe Pro Asn Ala Ser Asp 
                405                 410                 415     


Phe Gln Pro His Arg Trp Asp Glu Thr Val Glu Pro Val Ser Ala Asp 
            420                 425                 430         


Ala Lys Glu Thr Val Asp Tyr Gly Phe Gly Lys Val Ser Lys Gly Val 
        435                 440                 445             


Ser Ser Pro Tyr Leu Pro Phe Gly Gly Gly Arg His Arg Cys Ile Gly 
    450                 455                 460                 


Glu His Phe Ala Tyr Cys Gln Leu Gly Thr Ile Leu Asn Thr Phe Val 
465                 470                 475                 480 


Arg Thr Phe Lys Trp Lys Ala Val Val Pro Gln Pro Asp Tyr Thr Ser 
                485                 490                 495     


Met Val Thr Leu Pro Glu Pro Asn Leu Ser Thr Ile Thr Trp Glu Arg 
            500                 505                 510         


Arg Asp Asn 
        515 


<210>  13
<211>  986
<212>  PRT
<213>  Pichia pastoris

<400>  13

Met Leu Thr Gly Leu Ser Lys Ile Cys Ala His Arg Pro Ile His Thr 
1               5                   10                  15      


Ile Val Val Thr Ala Leu Leu Val Ser Leu Ala Tyr Leu Thr Ile Val 
            20                  25                  30          


Glu Glu Tyr Thr Ser Arg Ser Ser Leu Ser Asn Pro Phe Ile Ser Phe 
        35                  40                  45              


Tyr His Pro Pro Gly Asn Ser Asp Tyr Gln Asn Trp Ile Pro Val Asp 
    50                  55                  60                  


Asp Ser Val Lys Leu Lys Ser Lys Ser Ala Gln His Leu Ser Val Cys 
65                  70                  75                  80  


Ala Leu Lys Phe Lys Arg Val Asn Gly His Gln Ile Pro Asp Leu Ala 
                85                  90                  95      


Gly Ser Phe Gln Ser Ala Asp Pro Thr Glu Ile Phe Val Val Gln Asp 
            100                 105                 110         


Phe Asp Lys Ser Phe Asp Tyr Phe Asp Ser Ile Ser Thr Ile Glu Gly 
        115                 120                 125             


Lys Asp Gly Ile Gln Trp Lys Val Arg His Pro Asn Arg Leu Gly Arg 
    130                 135                 140                 


Tyr Ser Glu Tyr Phe Arg Ser Val Phe Ser Lys Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Gly Ala Glu Pro Phe Asp Ile Val Leu Ile Ala Phe Ala Tyr Val 
                165                 170                 175     


Ala Met Trp Tyr Thr Phe Leu Gln Leu Tyr Tyr Glu Met Lys Thr Lys 
            180                 185                 190         


Ala Asn Ser Asn Phe Trp Leu Thr Phe Gly Ser Leu Leu Ser Ser Gly 
        195                 200                 205             


Cys Ala Phe Val Phe Ala Leu Ala Val Thr Val Lys Val Tyr Gly Ile 
    210                 215                 220                 


Lys Val Pro Leu Thr Ser Leu Thr Glu Gly Val Pro Phe Leu Val Ala 
225                 230                 235                 240 


Thr Ile Gly Phe Lys His Lys Val Ala Phe Thr Val Pro Ile Leu Gln 
                245                 250                 255     


Ala Ser Arg Ser Lys Lys Ala Lys Glu Ile Pro Asp Thr Ile Ile Ser 
            260                 265                 270         


Val Ile Glu Gln Thr Thr Gly Trp Pro Leu Ile Lys Asp His Leu Ile 
        275                 280                 285             


Met Ile Ser Ala Phe Leu Ala Cys Ser Phe Tyr Ala Pro Arg Met Glu 
    290                 295                 300                 


Gly Leu Lys Asn Phe Cys Ile Leu Ser Ala Asn Ile Leu Thr Phe Asp 
305                 310                 315                 320 


Leu Ile Met Ile Phe Thr Phe Phe Thr Ala Val Leu Ser Leu Lys Ala 
                325                 330                 335     


Gln Ile Asn Lys Val His Glu Thr Thr Ala Leu Gln Gln Val Leu Glu 
            340                 345                 350         


Glu Asp Gly Ile Ala Glu Asp Val Ala Glu Arg Ile Ala Ala Ser Asn 
        355                 360                 365             


Arg Asn Met Phe Ser Arg Ser Thr Ser Val Val Ser Phe Lys Val Ile 
    370                 375                 380                 


Met Ile Ala Gly Phe Leu Gly Phe His Leu Phe Val Leu Gly Thr Ser 
385                 390                 395                 400 


Trp Leu Tyr Asp Ser Asp Val Ser Ser Ser Ser Ile Phe Gly Lys Ser 
                405                 410                 415     


Asn Val Ser Ala Leu Ser Lys Ala Ala Ala Lys His Ile Pro Ile Gly 
            420                 425                 430         


Ser Glu Gly Thr Ile Val Thr Ile Met Pro Thr Arg Val Tyr Met Pro 
        435                 440                 445             


Val Asp Leu Leu Leu Lys Leu Glu Asp Asp Phe Leu Asn Ile Phe Ser 
    450                 455                 460                 


Lys Ile Ser Ala Ser Ile Thr Asp Pro Leu Ile Ser Lys Leu Leu Phe 
465                 470                 475                 480 


Ile Ile Thr Gly Ile Ser Ala Thr Ile Asn Val Tyr Leu Leu Asn Ala 
                485                 490                 495     


Ala Arg Phe His Ser Ser Arg Glu Ile Ala Val Ser Thr Ile Ala Lys 
            500                 505                 510         


Pro Gln Thr Pro Asp Val Val Pro Thr Val Glu Pro Leu Pro Asn Glu 
        515                 520                 525             


Asn Asp Thr Ser Ile Arg Pro Leu Glu Glu Met Val Ser Leu Leu Lys 
    530                 535                 540                 


Glu Gly Lys Thr Arg Glu Leu Asn Asn Asp Glu Val Ser Ser Leu Val 
545                 550                 555                 560 


Val Gln Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Gln Leu Val Asp 
                565                 570                 575     


Lys Thr Arg Ala Val Ile Val Arg Arg Lys Ala Ile Ala Ser Leu Ala 
            580                 585                 590         


Asp Ala Pro Val Leu Arg Thr Glu Lys Leu Pro Tyr Lys Asp Tyr Asp 
        595                 600                 605             


Tyr Asp Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly Phe Met 
    610                 615                 620                 


Pro Leu Pro Val Gly Val Ala Gly Pro Leu Ile Ile Asp Gly Lys Pro 
625                 630                 635                 640 


Tyr His Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser Thr 
                645                 650                 655     


Met Arg Gly Cys Lys Ala Ile Asn Ser Gly Gly Gly Val Glu Thr Val 
            660                 665                 670         


Leu Thr Ala Asp Gly Met Thr Arg Gly Pro Cys Val Ser Phe Pro Ser 
        675                 680                 685             


Leu Ser Arg Ala Gly Ala Ala Lys Met Trp Leu Asp Ser Glu Glu Gly 
    690                 695                 700                 


Gln Lys Thr Ile Lys Gly Ala Phe Asn Ser Thr Ser Arg Phe Ala Arg 
705                 710                 715                 720 


Leu Gln His Val Lys Thr Thr Leu Ala Gly Thr Leu Leu Phe Ile Arg 
                725                 730                 735     


Phe Lys Thr Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile Ser Lys 
            740                 745                 750         


Gly Val Glu Tyr Ser Leu Lys Phe Met Ser Glu Glu Cys Asp Trp Pro 
        755                 760                 765             


Asp Met Glu Val Ile Ser Val Ser Gly Asn Tyr Cys Thr Asp Lys Lys 
    770                 775                 780                 


Val Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Ala 
785                 790                 795                 800 


Glu Ala Arg Ile Pro Ala Asp Val Val Arg Ser Val Leu Lys Ser Asp 
                805                 810                 815     


Val Glu Ala Leu Val Glu Leu Asn Val Ser Lys Asn Leu Ile Gly Ser 
            820                 825                 830         


Ala Met Ala Gly Ser Ile Gly Gly Phe Asn Ala Gln Ala Ala Asn Leu 
        835                 840                 845             


Val Thr Ala Val Tyr Leu Ala Thr Gly Gln Asp Pro Ala Gln Asn Val 
    850                 855                 860                 


Glu Ser Ser Asn Cys Ile Thr Leu Met Asn Lys Leu Pro Asn Gly Asp 
865                 870                 875                 880 


Leu Gln Ile Ser Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile Gly 
                885                 890                 895     


Gly Gly Thr Val Leu Glu Pro Gln Gly Ser Met Leu Glu Leu Leu Gly 
            900                 905                 910         


Val Lys Gly Pro His Pro Thr Asn Pro Gly Ala Asn Ser Arg Gln Leu 
        915                 920                 925             


Ala Lys Ile Val Ala Ser Ala Val Leu Ala Ala Glu Leu Ser Leu Cys 
    930                 935                 940                 


Ser Ala Leu Ala Ala Gly His Leu Val Gln Ser His Met Thr His Asn 
945                 950                 955                 960 


Arg Lys Gln Ala Pro Val Lys Glu Val Asn Gly Thr Ala Ala Arg Leu 
                965                 970                 975     


Ala Glu Gln Ser Lys Ile Cys Ile Lys Ser 
            980                 985     


<210>  14
<211>  471
<212>  PRT
<213>  Pichia pastoris

<400>  14

Met Thr Pro Asp Val Val Pro Thr Val Glu Pro Leu Pro Asn Glu Asn 
1               5                   10                  15      


Asp Thr Ser Ile Arg Pro Leu Glu Glu Met Val Ser Leu Leu Lys Glu 
            20                  25                  30          


Gly Lys Thr Arg Glu Leu Asn Asn Asp Glu Val Ser Ser Leu Val Val 
        35                  40                  45              


Gln Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Gln Leu Val Asp Lys 
    50                  55                  60                  


Thr Arg Ala Val Ile Val Arg Arg Lys Ala Ile Ala Ser Leu Ala Asp 
65                  70                  75                  80  


Ala Pro Val Leu Arg Thr Glu Lys Leu Pro Tyr Lys Asp Tyr Asp Tyr 
                85                  90                  95      


Asp Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly Phe Met Pro 
            100                 105                 110         


Leu Pro Val Gly Val Ala Gly Pro Leu Ile Ile Asp Gly Lys Pro Tyr 
        115                 120                 125             


His Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser Thr Met 
    130                 135                 140                 


Arg Gly Cys Lys Ala Ile Asn Ser Gly Gly Gly Val Glu Thr Val Leu 
145                 150                 155                 160 


Thr Ala Asp Gly Met Thr Arg Gly Pro Cys Val Ser Phe Pro Ser Leu 
                165                 170                 175     


Ser Arg Ala Gly Ala Ala Lys Met Trp Leu Asp Ser Glu Glu Gly Gln 
            180                 185                 190         


Lys Thr Ile Lys Gly Ala Phe Asn Ser Thr Ser Arg Phe Ala Arg Leu 
        195                 200                 205             


Gln His Val Lys Thr Thr Leu Ala Gly Thr Leu Leu Phe Ile Arg Phe 
    210                 215                 220                 


Lys Thr Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile Ser Lys Gly 
225                 230                 235                 240 


Val Glu Tyr Ser Leu Lys Phe Met Ser Glu Glu Cys Asp Trp Pro Asp 
                245                 250                 255     


Met Glu Val Ile Ser Val Ser Gly Asn Tyr Cys Thr Asp Lys Lys Val 
            260                 265                 270         


Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Ala Glu 
        275                 280                 285             


Ala Arg Ile Pro Ala Asp Val Val Arg Ser Val Leu Lys Ser Asp Val 
    290                 295                 300                 


Glu Ala Leu Val Glu Leu Asn Val Ser Lys Asn Leu Ile Gly Ser Ala 
305                 310                 315                 320 


Met Ala Gly Ser Ile Gly Gly Phe Asn Ala Gln Ala Ala Asn Leu Val 
                325                 330                 335     


Thr Ala Val Tyr Leu Ala Thr Gly Gln Asp Pro Ala Gln Asn Val Glu 
            340                 345                 350         


Ser Ser Asn Cys Ile Thr Leu Met Asn Lys Leu Pro Asn Gly Asp Leu 
        355                 360                 365             


Gln Ile Ser Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile Gly Gly 
    370                 375                 380                 


Gly Thr Val Leu Glu Pro Gln Gly Ser Met Leu Glu Leu Leu Gly Val 
385                 390                 395                 400 


Lys Gly Pro His Pro Thr Asn Pro Gly Ala Asn Ser Arg Gln Leu Ala 
                405                 410                 415     


Lys Ile Val Ala Ser Ala Val Leu Ala Ala Glu Leu Ser Leu Cys Ser 
            420                 425                 430         


Ala Leu Ala Ala Gly His Leu Val Gln Ser His Met Thr His Asn Arg 
        435                 440                 445             


Lys Gln Ala Pro Val Lys Glu Val Asn Gly Thr Ala Ala Arg Leu Ala 
    450                 455                 460                 


Glu Gln Ser Lys Ile Cys Ile 
465                 470     


<210>  15
<211>  504
<212>  PRT
<213>  Pichia pastoris

<400>  15

Met Gly Ile Ser Ala Thr Ile Asn Val Tyr Leu Leu Asn Ala Ala Arg 
1               5                   10                  15      


Phe His Ser Ser Arg Glu Ile Ala Val Ser Thr Ile Ala Lys Pro Gln 
            20                  25                  30          


Thr Pro Asp Val Val Pro Thr Val Glu Pro Leu Pro Asn Glu Asn Asp 
        35                  40                  45              


Thr Ser Ile Arg Pro Leu Glu Glu Met Val Ser Leu Leu Lys Glu Gly 
    50                  55                  60                  


Lys Thr Arg Glu Leu Asn Asn Asp Glu Val Ser Ser Leu Val Val Gln 
65                  70                  75                  80  


Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Gln Leu Val Asp Lys Thr 
                85                  90                  95      


Arg Ala Val Ile Val Arg Arg Lys Ala Ile Ala Ser Leu Ala Asp Ala 
            100                 105                 110         


Pro Val Leu Arg Thr Glu Lys Leu Pro Tyr Lys Asp Tyr Asp Tyr Asp 
        115                 120                 125             


Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly Phe Met Pro Leu 
    130                 135                 140                 


Pro Val Gly Val Ala Gly Pro Leu Ile Ile Asp Gly Lys Pro Tyr His 
145                 150                 155                 160 


Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser Thr Met Arg 
                165                 170                 175     


Gly Cys Lys Ala Ile Asn Ser Gly Gly Gly Val Glu Thr Val Leu Thr 
            180                 185                 190         


Ala Asp Gly Met Thr Arg Gly Pro Cys Val Ser Phe Pro Ser Leu Ser 
        195                 200                 205             


Arg Ala Gly Ala Ala Lys Met Trp Leu Asp Ser Glu Glu Gly Gln Lys 
    210                 215                 220                 


Thr Ile Lys Gly Ala Phe Asn Ser Thr Ser Arg Phe Ala Arg Leu Gln 
225                 230                 235                 240 


His Val Lys Thr Thr Leu Ala Gly Thr Leu Leu Phe Ile Arg Phe Lys 
                245                 250                 255     


Thr Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile Ser Lys Gly Val 
            260                 265                 270         


Glu Tyr Ser Leu Lys Phe Met Ser Glu Glu Cys Asp Trp Pro Asp Met 
        275                 280                 285             


Glu Val Ile Ser Val Ser Gly Asn Tyr Cys Thr Asp Lys Lys Val Ala 
    290                 295                 300                 


Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Ala Glu Ala 
305                 310                 315                 320 


Arg Ile Pro Ala Asp Val Val Arg Ser Val Leu Lys Ser Asp Val Glu 
                325                 330                 335     


Ala Leu Val Glu Leu Asn Val Ser Lys Asn Leu Ile Gly Ser Ala Met 
            340                 345                 350         


Ala Gly Ser Ile Gly Gly Phe Asn Ala Gln Ala Ala Asn Leu Val Thr 
        355                 360                 365             


Ala Val Tyr Leu Ala Thr Gly Gln Asp Pro Ala Gln Asn Val Glu Ser 
    370                 375                 380                 


Ser Asn Cys Ile Thr Leu Met Asn Lys Leu Pro Asn Gly Asp Leu Gln 
385                 390                 395                 400 


Ile Ser Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile Gly Gly Gly 
                405                 410                 415     


Thr Val Leu Glu Pro Gln Gly Ser Met Leu Glu Leu Leu Gly Val Lys 
            420                 425                 430         


Gly Pro His Pro Thr Asn Pro Gly Ala Asn Ser Arg Gln Leu Ala Lys 
        435                 440                 445             


Ile Val Ala Ser Ala Val Leu Ala Ala Glu Leu Ser Leu Cys Ser Ala 
    450                 455                 460                 


Leu Ala Ala Gly His Leu Val Gln Ser His Met Thr His Asn Arg Lys 
465                 470                 475                 480 


Gln Ala Pro Val Lys Glu Val Asn Gly Thr Ala Ala Arg Leu Ala Glu 
                485                 490                 495     


Gln Ser Lys Ile Cys Ile Lys Ser 
            500                 


<210>  16
<211>  460
<212>  PRT
<213>  Pichia pastoris

<400>  16

Met Pro Glu Lys Lys Asn Ser Arg Ser Ala Asp Glu Ala Leu Ser Phe 
1               5                   10                  15      


Leu Ala Lys Thr Asn Val Glu Arg Pro Met His Tyr Ser Lys Thr Gly 
            20                  25                  30          


Asn Ile Thr Pro Asp Thr Val Ser Ser Arg Glu Asp His Tyr Gln Asp 
        35                  40                  45              


Tyr Asp Asp Ser Gln Asp Asp Ile Ile Asn Asn Lys Leu Leu Gln Arg 
    50                  55                  60                  


Arg Gln Gly Gly Pro His Asn Lys Ile Glu Lys Gln Arg Arg Phe Ala 
65                  70                  75                  80  


Leu Leu Arg Ser Ser Leu Asn Arg Arg Leu Glu Thr Leu Val Ile Leu 
                85                  90                  95      


Trp His Thr Ile Thr Ile Pro Phe Leu Ala Ser Leu Phe Phe Val Leu 
            100                 105                 110         


Cys Thr Ile Pro Met Leu Trp Pro Leu Ile Ile Val Tyr Leu Val Tyr 
        115                 120                 125             


Phe Tyr Ile Asp Ala Asn Thr Pro Ser Asn Gly Lys Ser Ala Asp Arg 
    130                 135                 140                 


Arg Val Glu Trp Phe Arg Ser Leu His Ile Trp Lys His Phe Val Asn 
145                 150                 155                 160 


Tyr Tyr Pro Ile Ser Val Tyr Lys Thr Val Asp Leu Glu Pro Thr Phe 
                165                 170                 175     


Lys Thr Lys Lys Ile Glu Ile Ile Leu Pro Lys Tyr His Gln Val Thr 
            180                 185                 190         


Thr Tyr Leu Pro Ser Ser Val Arg Lys Tyr Ile Pro Thr His Arg Val 
        195                 200                 205             


Leu Ile Glu Lys Glu Ile Lys Thr Gly Pro Arg Tyr Ile Phe Gly Tyr 
    210                 215                 220                 


His Pro His Gly Val Val Ser Leu Gly Ile Thr Gly Ala Phe Gly Thr 
225                 230                 235                 240 


Asn Gly Cys Asn Ile Gly Glu Leu Leu Pro Gly Ile Arg Ile Tyr Leu 
                245                 250                 255     


Leu Thr Leu Ile Thr Gln Phe Lys Leu Pro Leu Leu Arg Asp Tyr Leu 
            260                 265                 270         


Met Ala Leu Gly Ile Ser Ser Val Ser Lys Arg Asn Val Thr Ala Leu 
        275                 280                 285             


Ile Lys Arg Asn Gln Ser Val Cys Ile Val Ile Gly Gly Ala Ser Glu 
    290                 295                 300                 


Ser Leu Leu Ser Lys Pro His Thr Ile Asp Ile Val Leu Lys Lys Arg 
305                 310                 315                 320 


Lys Gly Phe Val Lys Val Ala Leu Glu Leu Gly Asp Thr Glu Leu Val 
                325                 330                 335     


Pro Val Phe Gly Phe Gly Glu Asn Thr Ala Tyr Asn Val Phe Asp Pro 
            340                 345                 350         


Ser Val Ser Gly Lys Ser Cys Ser Val Leu Asn Tyr Val Arg Lys Gln 
        355                 360                 365             


Met Cys Gly Phe Gln Leu Trp Leu Lys Gln His Phe Gly Phe Thr Phe 
    370                 375                 380                 


Pro Phe Phe His Ala Arg Gly Val Phe Asn His Asp Phe Gly Leu Leu 
385                 390                 395                 400 


Pro Tyr Arg Lys Pro Ile Asn Leu Val Ile Gly Arg Pro Ile Pro Val 
                405                 410                 415     


Pro Tyr Ile His Ser Pro Thr Gln Glu Gln Ile Asp His Tyr His Ser 
            420                 425                 430         


Leu Tyr Val Glu Glu Leu Lys Arg Val Phe Glu Gln Asn Lys Glu Arg 
        435                 440                 445             


Phe Asn Ala Gly Ser Leu Glu Leu Arg Ile Val Glu 
    450                 455                 460 


<210>  17
<211>  652
<212>  PRT
<213>  Pichia pastoris

<400>  17

Met Gln Leu Arg Lys Arg Gly Asn Glu Arg Ser Arg Leu Glu Ser His 
1               5                   10                  15      


Ile Gly Asp Ser Asp Thr Val Ile Asp Leu Asp Asp Ser Ser Val Asn 
            20                  25                  30          


Asp Thr Leu Pro Asp Glu Asp Asn Ile Ala Lys Pro Arg Lys Ala Ser 
        35                  40                  45              


Thr His Arg Arg Pro Ser Leu Arg Lys Ile His Ser Ala Glu Thr Val 
    50                  55                  60                  


Arg Arg Phe Tyr Glu Ser Lys Asn Val Ile Phe Ile Phe Gly Ala Phe 
65                  70                  75                  80  


Ile Gly Ile Ala Val Ala Leu Tyr Phe Gly Ala Thr Ser Ser Glu Tyr 
                85                  90                  95      


Pro Ile Pro Asp Ile Asp Gln Leu Val Asn Phe Asp Ser Leu Ser Thr 
            100                 105                 110         


Tyr Phe Asp Asp Trp Lys Asp Val Leu Pro Lys Ser Leu Gln Ser Ile 
        115                 120                 125             


Val Glu Ser Thr Gln Phe Asn Gln Asn Ser Lys Ile Leu Ser Ser Glu 
    130                 135                 140                 


Ser Phe Ala Val Gly Lys Gln Leu Lys Ser Lys Ser Met Ile Glu Ala 
145                 150                 155                 160 


Asn His Ser Ile Val Leu Val Pro Gly Val Ile Ser Thr Gly Leu Glu 
                165                 170                 175     


Ser Trp Gly Leu Glu Gly Thr Pro Asp Cys Pro Ser Glu Gly His Phe 
            180                 185                 190         


Arg Lys Arg Leu Trp Gly Ser Phe Tyr Met Leu Arg Thr Met Phe Leu 
        195                 200                 205             


Asp Lys Ala Cys Trp Leu Lys His Ile Met Leu Asp Thr Thr Thr Gly 
    210                 215                 220                 


Leu Asp Pro Pro Gly Ile Ser Leu Arg Ala Ala Gln Gly Phe Glu Ala 
225                 230                 235                 240 


Ala Asp Phe Phe Ile Ala Gly Tyr Trp Ile Trp Asn Lys Ile Leu Gln 
                245                 250                 255     


Asn Leu Ala Val Ile Gly Tyr Asn Pro Asn Asn Met Val Ser Ala Ala 
            260                 265                 270         


Tyr Asp Trp Arg Leu Ala Phe Leu Asp Leu Glu Leu Arg Asp Ala Tyr 
        275                 280                 285             


Phe Ser Lys Leu Lys Gly Phe Val Glu Leu Gln Lys His Gln Ser Gly 
    290                 295                 300                 


Lys Lys Ser Val Leu Val Gly His Ser Met Gly Ser Gln Val Ile Tyr 
305                 310                 315                 320 


Tyr Phe Met Lys Trp Val Glu Ala Asp Gly Tyr Gly Asn Gly Gly Pro 
                325                 330                 335     


Asn Trp Val Asn Asp His Val Asp Ser Phe Val Asp Ile Ser Gly Cys 
            340                 345                 350         


Met Leu Gly Thr Pro Lys Ala Ile Pro Ala Leu Leu Ser Gly Glu Met 
        355                 360                 365             


Lys Asp Thr Val Gln Leu Asn Ala Leu Ala Val Glu Gly Leu Glu Lys 
    370                 375                 380                 


Phe Leu Ser Arg Arg Glu Arg Ala Asp Met Ile Arg Ser Phe Gly Gly 
385                 390                 395                 400 


Ile Ala Ser Met Ile Pro Lys Gly Gly Asp Leu Ile Trp Gly Asn Leu 
                405                 410                 415     


Glu Ser Ser Pro Asp Asp Ala Thr Ser Ile Gly Asp Leu Gly Asn Asp 
            420                 425                 430         


Thr Tyr Gly Asn Phe Ile Arg Phe Lys Glu Pro Val Gly Lys Tyr Ser 
        435                 440                 445             


Gln Lys Asn Leu Thr Val Thr Asp Ser Ile Gln Phe Leu Met Glu Gln 
    450                 455                 460                 


Thr Pro Ala Trp Phe Gln Asp Arg Met Leu Arg Ala Tyr Ser Tyr Gly 
465                 470                 475                 480 


Phe Thr Asn Ser Ala Lys Gln Leu Lys Lys Asn Asn Lys Asp His Thr 
                485                 490                 495     


Lys Trp Ser Asn Pro Leu Glu Ala Ser Leu Pro Asn Ala Pro Asp Leu 
            500                 505                 510         


Lys Val Phe Cys Phe Tyr Gly Phe Gly Asn Pro Thr Glu Arg Ala Tyr 
        515                 520                 525             


Tyr Tyr Arg Glu Glu Val Asp Pro Ala Lys Thr Lys Leu Asn Val Thr 
    530                 535                 540                 


Ile Glu Lys Asn Tyr Asp Ser Val Leu Met Ala Asp Gly Asp Gly Thr 
545                 550                 555                 560 


Val Ser Leu Met Thr His Ser Met Cys His Ile Trp Lys Gln Ala Asn 
                565                 570                 575     


Ser Val Tyr Asn Pro Gly Asn Ser Lys Val Lys Ile Val Glu Ile Asp 
            580                 585                 590         


His Glu Pro Asp Arg Phe Asp Ile Arg Gly Gly Ala Lys Thr Ala Glu 
        595                 600                 605             


His Val Asp Ile Leu Gly Ser Ala Glu Leu Asn Glu Leu Val Leu Leu 
    610                 615                 620                 


Val Ala Ala Gly Lys Gly Asp Gln Ile Lys Glu Lys Ile Val Ser Asn 
625                 630                 635                 640 


Leu Lys Glu Ile Val Asp Asn Leu Glu Leu Asp Leu 
                645                 650         


<210>  18
<211>  678
<212>  PRT
<213>  Pichia pastoris

<400>  18

Met Leu Ser Leu Lys Pro Ser Trp Leu Thr Leu Ala Ala Leu Met Tyr 
1               5                   10                  15      


Ala Met Leu Leu Val Val Val Pro Phe Ala Lys Pro Val Arg Ala Asp 
            20                  25                  30          


Asp Val Glu Ser Tyr Gly Thr Val Ile Gly Ile Asp Leu Gly Thr Thr 
        35                  40                  45              


Tyr Ser Cys Val Gly Val Met Lys Ser Gly Arg Val Glu Ile Leu Ala 
    50                  55                  60                  


Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser Tyr Val Ser Phe Thr Glu 
65                  70                  75                  80  


Asp Glu Arg Leu Val Gly Asp Ala Ala Lys Asn Leu Ala Ala Ser Asn 
                85                  90                  95      


Pro Lys Asn Thr Ile Phe Asp Ile Lys Arg Leu Ile Gly Met Lys Tyr 
            100                 105                 110         


Asp Ala Pro Glu Val Gln Arg Asp Leu Lys Arg Leu Pro Tyr Thr Val 
        115                 120                 125             


Lys Ser Lys Asn Gly Gln Pro Val Val Ser Val Glu Tyr Lys Gly Glu 
    130                 135                 140                 


Glu Lys Ser Phe Thr Pro Glu Glu Ile Ser Ala Met Val Leu Gly Lys 
145                 150                 155                 160 


Met Lys Leu Ile Ala Glu Asp Tyr Leu Gly Lys Lys Val Thr His Ala 
                165                 170                 175     


Val Val Thr Val Pro Ala Tyr Phe Asn Asp Ala Gln Arg Gln Ala Thr 
            180                 185                 190         


Lys Asp Ala Gly Leu Ile Ala Gly Leu Thr Val Leu Arg Ile Val Asn 
        195                 200                 205             


Glu Pro Thr Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Thr Gly Glu 
    210                 215                 220                 


Glu Arg Gln Ile Ile Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Val 
225                 230                 235                 240 


Ser Leu Leu Ser Ile Glu Gly Gly Ala Phe Glu Val Leu Ala Thr Ala 
                245                 250                 255     


Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Tyr Arg Val Val Arg 
            260                 265                 270         


His Phe Val Lys Ile Phe Lys Lys Lys His Asn Ile Asp Ile Ser Asn 
        275                 280                 285             


Asn Asp Lys Ala Leu Gly Lys Leu Lys Arg Glu Val Glu Lys Ala Lys 
    290                 295                 300                 


Arg Thr Leu Ser Ser Gln Met Thr Thr Arg Ile Glu Ile Asp Ser Phe 
305                 310                 315                 320 


Val Asp Gly Ile Asp Phe Ser Glu Gln Leu Ser Arg Ala Lys Phe Glu 
                325                 330                 335     


Glu Ile Asn Ile Glu Leu Phe Lys Lys Thr Leu Lys Pro Val Glu Gln 
            340                 345                 350         


Val Leu Lys Asp Ala Gly Val Lys Lys Ser Glu Ile Asp Asp Ile Val 
        355                 360                 365             


Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Gln Leu Leu Glu 
    370                 375                 380                 


Asp Tyr Phe Asp Gly Lys Lys Ala Ser Lys Gly Ile Asn Pro Asp Glu 
385                 390                 395                 400 


Ala Val Ala Tyr Gly Ala Ala Val Gln Ala Gly Val Leu Ser Gly Glu 
                405                 410                 415     


Glu Gly Val Asp Asp Ile Val Leu Leu Asp Val Asn Pro Leu Thr Leu 
            420                 425                 430         


Gly Ile Glu Thr Thr Gly Gly Val Met Thr Thr Leu Ile Asn Arg Asn 
        435                 440                 445             


Thr Ala Ile Pro Thr Lys Lys Ser Gln Ile Phe Ser Thr Ala Ala Asp 
    450                 455                 460                 


Asn Gln Pro Thr Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala Leu 
465                 470                 475                 480 


Ala Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile Pro 
                485                 490                 495     


Pro Ala Pro Arg Gly Thr Pro Gln Val Glu Val Thr Phe Val Leu Asp 
            500                 505                 510         


Ala Asn Gly Ile Leu Lys Val Ser Ala Thr Asp Lys Gly Thr Gly Lys 
        515                 520                 525             


Ser Glu Ser Ile Thr Ile Asn Asn Asp Arg Gly Arg Leu Ser Lys Glu 
    530                 535                 540                 


Glu Val Asp Arg Met Val Glu Glu Ala Glu Lys Tyr Ala Ala Glu Asp 
545                 550                 555                 560 


Ala Ala Leu Arg Glu Lys Ile Glu Ala Arg Asn Ala Leu Glu Asn Tyr 
                565                 570                 575     


Ala His Ser Leu Arg Asn Gln Val Thr Asp Asp Ser Glu Thr Gly Leu 
            580                 585                 590         


Gly Ser Lys Leu Asp Glu Asp Asp Lys Glu Thr Leu Thr Asp Ala Ile 
        595                 600                 605             


Lys Asp Thr Leu Glu Phe Leu Glu Asp Asn Phe Asp Thr Ala Thr Lys 
    610                 615                 620                 


Glu Glu Leu Asp Glu Gln Arg Glu Lys Leu Ser Lys Ile Ala Tyr Pro 
625                 630                 635                 640 


Ile Thr Ser Lys Leu Tyr Gly Ala Pro Glu Gly Gly Thr Pro Pro Gly 
                645                 650                 655     


Gly Gln Gly Phe Asp Asp Asp Asp Gly Asp Phe Asp Tyr Asp Tyr Asp 
            660                 665                 670         


Tyr Asp His Asp Glu Leu 
        675             


<210>  19
<211>  993
<212>  DNA
<213>  Pichia pastoris

<400>  19
atgagtgaca ttaatactct gtcgcagaag attccgtcgt atgttcaata cggtattccc       60

agtattgatc atccttttgg aatccgttta tggccaattt tcagtcattt ctttgaagcg      120

gttgttggat acccggctga agatttccgc tttattcagg gtctgactac catggccaat      180

ctaaaagacg ccctcggtgt tattgctgtt tattactttg tgatttttgg tggacaatgg      240

ttgatgagga ccctgaacgc tcgtcctttc aagttgaatt tcttgtttca attgcacaat      300

ttggttttga ccggggcgtc gtttaccttg ttgatattga tcgtggaaca gttaatccca      360

ggtatttatc gccatggaat attttgggct atttgccaca aggattcttt caccaacgaa      420

cttgtcacgc tatattacct gaactacttg atcaagtacg tggagttgat cgataccgtg      480

tttttggtcc tgaaacgcaa aaagttactt ttcttgcaca cttaccacca tggtgccact      540

gcattactat gctacaccca gctactcgga cacactgccg tcgaatgggt cccaattgcc      600

ctgaatctgg ctgttcacgt cgtcttgtac tggtactact tcctctctgc acgtggaatt      660

cgtgtatggt ggaagcaatg ggtgaccaga ttccaaatta ttcagttctt gatcgaccta      720

gggtttgtct actttgctac ctataccttc tacgctgaca aatacttccc cgagctaccc      780

aacatgggaa catgttatgg gactgaggaa gctgctgctt tcggatactt gatcctcaca      840

tcgtatttgg tcctattcat tctcttttac attcgtgtct acaagtccgg gcccacaaca      900

agcaagggga aatcaaaggc agctgctact accggtcaaa aaactgagac tgcctcccct      960

tctggcaaaa gcactagtgt ccgtcgtgcc taa                                   993


<210>  20
<211>  1005
<212>  DNA
<213>  Pichia pastoris

<400>  20
atgtccattc tctcatttga taagcccttt ggcatcgaac tatggcccat tttcgatact       60

tttgcctcta aagccaccca cggtgctttt gttccttccg agtttgagtt tgttgctgga      120

aaactgcctt tatccactct ggaaccagta ttgtacagca ttgccgcgta ctactttatc      180

gtcttcggtg gctattattt tattaagaag ctggagctaa agccactagt tttaaatgcg      240

ttgttttctg ctcacaactt gtttttaact actgcttctt tggtgctgtt aactttgatg      300

gttgaacagc tcgttcctat tatttaccac catggacttt tctatgctat ttgcaacact      360

agggcttgga ctcaagagct tgtcactttg tactacctga attacctgat caagttcgta      420

gagtttattg acacattctt tttggttgtc aaacagaaaa agctgacatt tttacacact      480

taccaccacg gtgctactgc tttgctatgt tacactcagt tggttggtgt cacttccatc      540

tcttgggtcc caatctccct gaatctgggt gtccacgttg tcatgtactg gtattacttt      600

ctggcttcga gaggtatccg tgtatggtgg aaggaatggg tcactagatt tcaaattatg      660

caatttattt tggatcttgg atttgtttat tttgccagtt accaaaagtt tgcctacact      720

tatttcaagg acgttctgcc atactgtggt gactgtgctg gaaccatggt agccgctgtg      780

tctggttgtg ccattctgtc gtcctacttg gtccttttca ttgccttcta cattgaagtc      840

tacagaaaac aaggtaaaaa gtccagatac gttaaaaagg tcagaggtgg tgttgctgcc      900

aaggtcaacg agtatgttct tttggaagac aaacagttgg catccggtgc ttcctctcgt      960

tccagctccc ctgtgaccag aaatttgcgc tctcgcaagg cctga                     1005


<210>  21
<211>  1212
<212>  DNA
<213>  Pichia pastoris

<400>  21
atgtctaaag aggaaaagac aagacgtcga agagcgtcat ccattggaaa cataaaccta       60

ggtgacaatg cagttccttc tttgactacc cgaaagtcga atgctcagca gagaaagtct      120

agctccgccc gtattaattt aatcaacaag aagggaagtt ccgattgggg tttagttaaa      180

aaaattggac tttccttggt cgaactgagc tcgcgtcaca catggttgcc atttttggtt      240

tctttggttg ccatacatgg ctcgtatctg ttatctaata accacactcc atccaatcca      300

ttgcacaagt tcgttgatct ttcatataaa atcgaaggaa ctaaccctcc catgtatggc      360

aaaggatgga aagacttctg ctttgtgttt tacttcatga ttttcttcag tttctaccgt      420

gaatttttga tgcaagcgtt actgaaacct ttggccagta agttgggtat cacaagagag      480

tctaaagtca gaagattcat ggaacagtct tattcaatgt gctactatgg attttctggg      540

cccttgggtc tatatatcat ggcaggtatg cccttgtggt acttcaacac gacagaattc      600

tatattactt accctcacaa aagtcatgaa tatctgttca agtactatta tttgggtcaa      660

gccgctttct ggtctcaaca agctgttgtc ttgatgctac aattggaaaa gccgagaaaa      720

gatttcaagg agctggttat tcaccacatt atcaccattg cactgattta ctgtagttac      780

agatttcatt tcacttggat ggggcttgca gtctacatta ccatggacat ctctgacttc      840

ttcctggctc tttccaagac cctgaactat gttgattcag cttacactgg tcccgcgttc      900

atgttctttg tgggtgtctg gttctacttg cgccattggc tcaatgtcaa gatcctttgg      960

tctgtattga ctgaattccg taccgtaggt ccatttgaat tgaactggat cacacagcaa     1020

tacaaatgtt ggatttcaca accaattgta ttttcattga tttttgcctt gcagctggtg     1080

aatctgtact ggtttgtgtt aattctccgg attttgtacc gtcacatctt tttagatgtt     1140

accaaagacg aaagatccga cgatgaaagc gaagaagaag cccaagtaga accctccaag     1200

aaggaagaat ag                                                         1212


<210>  22
<211>  1137
<212>  DNA
<213>  Pichia pastoris

<400>  22
atgggtgttg aaacatcttc ctctggaact caacatttca gtgatgacgg ttgtgtatct       60

tcaaggaagc caaatgctac tgtaagcttt gagaagcctg agcgtgctaa cgagctgaag      120

aatcacaaaa tctataaaaa gtccaaggct tcatggttac agagaaatca aattttacta      180

gcatcttcat tgttgaacgc gttgttcatc ttaaagcaaa ttccctcatt tcaatcactc      240

gttaataaat tctttcattt acagtacaag aacttagatg gtacttatga tattggtaaa      300

gacgactatt ttttcgttat ttactggata atcaacttga ctattattcg cagtgtcttg      360

atggattggg tcctagaacc cttggcaatt aagatagttg ggattaacaa tagaaaagct      420

cttaccagat ttaaagaaca gggttggtct ttattctact acaccacgtc atggactgtg      480

ggcttctatt tatactacaa gtccgactat tttttcaatt gtgatcatat tttcatcggc      540

tggcccaaca ataagctgga tttctacttc aaatcttact acttgattca aatgtcatgt      600

tggctccagc agatcgttgt tttgaacata gaggagagaa gaaaagatta tgttcaaatg      660

ttctcgcatc atataataac ctgtttgctg attattggct cttactacta ttacttttta      720

cagattggac acgtcatttt ggttatgatg gacattgttg acgtttttct cagtcttgcc      780

aaaatgttaa aatactgtgg ttacagcact ctctgcgacg tgatgttttt catattcttg      840

gtttcatgga tagctataag acacgtgtgt tacaactacg tgttctggca cacatgcacc      900

aagtctaggg atctaatgaa cgcagattgt tccaggtacg caatctacgg aggtcccttg      960

gacgttactc cagtacgatg ctatacagat agtaccatta gatacttcat tttccttctt     1020

ggaggtctcc aaattatcac actaatctgg atgtacctca ttctaaaagt tttcataggg     1080

gtaataacgg gcaaaggtgc tgaagacgtt agaagtgatg atgaggagag ttcttga        1137


<210>  23
<211>  1191
<212>  DNA
<213>  Pichia pastoris

<400>  23
atgagccaac gtgaagaaac aaaagatgct gcaaagaaac agatcgcctt ttcgggaatt       60

ggagcctgcg gtcctccaaa cttctatggt acacaggatg ctcacgctag attggaagaa      120

gatctagccc gatttcttgg tgctgaacgt gccatattgt attcccagga tttctgtact      180

gtgccgtcag ttatagcatg ttttttgaaa agaggtgata ttgttgtgta tgactctggt      240

attgctttgg caacccaaaa gggaatcgaa ttatccagat gtaccgccta ccatttcaac      300

cataatgaca tggataacct ggagaaagtg ttagctgatc tgaagcccat gttagatgaa      360

ggacctttaa ctaggagatt tattatcaca gaaggtcttt ttcaaaactt tggagactct      420

ccagacttgc gtcgtatatg tgagctgaag aaaaagttca agtacagact gttcttagat      480

gaaactcttt caattggtgt tctaggtgct actggtagag gattgccaga attatacgga      540

atccctcgca cagacgttga ggtgaccacc ggcgctttat cctacgccct gggttcttct      600

ggaggattct gcgtcggtga aaacgccatg gtacatcacc agctaatttc ctctagtgcc      660

tatgtgtttt ctgcagctat tccaccttat tttgccagag ttgcatcggt atctcttcga      720

ttactccaag aagatgactc cgtgtcaaga ttacaatcca gtattaattt cctttactca      780

aagtttaaag aatgccagaa actcaaaaag ctggtaataa tcacttcatc tgacgtatct      840

ccaatcctac atctacgatt gcatcgtgac ttgagaagca gactcgatct tccggtgagt      900

tatggtggtc ccggatctgc tatggagaaa atagtacaga ggggagatga acacggttac      960

ttcgacgaaa attacaacag ggagtctcag atcttacaac aaattgtaga cagagtttta     1020

aacaaccata atatcctaat aacgagatgt aagaggatac ttcaccatga aaagctacca     1080

ttactgcctg agcttatgat ccatattaat gttgcatttt cggaatctga gctttcagaa     1140

gcatttgagg ccgtctcctc tgagatttac aatgttttgc aacagctttg a              1191


<210>  24
<211>  1686
<212>  DNA
<213>  Pichia pastoris

<400>  24
atgtcaaaaa ctatcccaga tgctctcata gacaatgatt caccacaaga gaaggccgag       60

aaagaatttg ggtccttgac cagtaaagaa tggctctttg tctctaagca taaccctggc      120

gagccgcttc cagttcccat cgaggacgaa cctccatatt tcatcctgat tgcaacatac      180

cttaattacc ttattttgat cataataggc catattagag acttctttgg gaagttgttt      240

caccctgaac tattcagaga tgtgatggtg aaagatggta ttgctccatg gtatgccaat      300

tttgaaagtt tctacacgcg tcgtttgaaa acaagattag atgactgttt tgcaaggccc      360

atatgtggag ttcccggtag gtacatcaaa tgttacgaca gaaccagtga cgattacaac      420

aatacctata attattccgg caccgtcaca gagcgcttga atttgagttc atacaactat      480

ttagggttcg cacaatcctc tggtctgtgc acctcagaaa gtatcaagac ggtggagaag      540

tatggtacca acagtgctgg tcctcgagtt agtgtgggaa ctactgatct ccatcttgaa      600

tgtgaggacg tcgttgccaa atttactggc aaggacaatg ctttggtatt ttccatgggt      660

tatgggacca atgcaaatct cttcacctct ttggtggact ctaagtgttg tgttatctca      720

gattctttaa accacggatc tatcaggaca ggtgttcgtt tgtctggcgc ctcagtcaaa      780

acttttgctc acaacgacat ggcagcgctg gaaagaactt tgagaagtgt catttcccaa      840

ggtcagccaa agactcatag accctggaag aagatttttg ttgctgtaga gggactttat      900

tccatggaag gaaccctttg taatttgcca aaactggtag aattgcgtaa gcgttacaag      960

ttttatttat ttgttgacga ggcacattct attggtgcta tgggacccaa tggtaagggt     1020

gtttgtgact attttggcat ttcttcttcc aatattgata ttatgatggg tacttttacc     1080

aaatcatttg gagccacagg cggttacatc gctgccgaca aagccatcat agacagattg     1140

aagttagatc tcacaacaaa tacttatgga gaatcaatgt cacctgctgt gctcacacaa     1200

atcattactt ctttgaaaat tatagatgga caactcaatg gtaatgaagg taaagagagg     1260

ctacaaagga ttgccttcaa ttctaggtat ctgcgattag gactaaagcg attaggattt     1320

attgtttatg gtgctgatga ttctcctgtt atcccccttt tactgtatct tccccccaag     1380

atgcctgcat ttagccgaat gatgtacgat agaaaggttg ctgtcgttgt tgtgggatat     1440

cctgcaacgg atataacgtc ttctcgtatt cgattctgcg tttcctcttc tttgaagaag     1500

gaggatatag attatttgct caaatgttgt gatgagatag gagatacttt gtttttgaag     1560

ttcagcacag ggattgctgg tggtgagaag cacccgggag actataagaa gggcattgct     1620

cctaggtgga cattggagga ggttctggag aagacaccgg aggattgcaa gaaagccatg     1680

tactaa                                                                1686


<210>  25
<211>  962
<212>  DNA
<213>  Pichia pastoris

<400>  25
atggttaaac tcattgttaa tccaaggtct gagaccctga gacaaatcaa cgtagacact       60

acccccaata caagagtcag agacattgtg gtagcttacg gaaaggcaaa taacagttta      120

tccagctcca gaatcagatt cactaaactg gaagaagacg cagtttccaa gaaaccaaag      180

catgtcactc tggactacga gaaatcctta gctcaaaatg ggatagtctt cacagatgat      240

tcagattcca aagaagtcta tgcgaaagat ttgggacccc agatcagttg gaaattagtg      300

ttcctgatcg aatacgtggg cccgctgatt attcatccat tgctctatta cggctggttc      360

aaacctgact ataacactct tacacagaaa gtttctttca ttttggtgat gctgcacttc      420

ctgaaacgtg aatacgaaac aacttttgtg cacctgtttt catctgatac aatgcctctt      480

ttcaacgttt tcaagaactc agctcattat tggattctta gtggattgag ccttgctgtc      540

actatttatg ctccggattc ataccgaaat aagtttgcac ccacttggaa acagtttttt      600

tccatgtatc tgaccatgaa gactccacag ttctagcact gattggactg tgggtatttg      660

ctgaattgtc caacttcatc actcaccaga aattggccag tctcagagcc gatggctcca      720

gagaacataa aattccctat ggatatggct tcaacctggt ctctttcccc aactatttct      780

ttgaatctgt agcttggttg gcatttgccc ttctcaacaa taactggtca tcttgggtgt      840

tccttaccat tgcctccatt cagatgtata tttgggccgc taagaaacac aaaagatatc      900

tcaaggagtt tggggaccaa tatcccaaga acaggaaagc aatgattcca ttccttttgt      960

ag                                                                     962


<210>  26
<211>  453
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  26
atgtctcaac ccactcccat cataactaca aaatcagctg ctaagccaaa accaaaaatt       60

tttaatttat tccgcgtttg cttcatttca ttattgctga tcgctgcggt tgaatacttc      120

aagtatggta caagaattaa ctatgaatgg ttccattgta ccccaatcaa agaaccccag      180

tctggctcag taatcaagct ttgggcacgt ggtgggccaa gttgtgacaa aagaggcgaa      240

tataaaacta tagtaaagag aatcactaga gattatgaac caaatgatga acatctctcg      300

ttctgtatca tcgagaatga taatgttcca cccgtccact acccaattca cgaagataaa      360

ggtgaacctg gctacgtagc ttatgtcggg tacgacacag actctgagct ggttcaagaa      420

ctatgtgctg attccacaat ttatcacatg tga                                   453


<210>  27
<211>  243
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  27
atgacacaac ataaaagctc gatggtgtac atacccacca ctaaggaagc taaaagacgt       60

aatgggaaat cagaaggcat actaaatact attgaagaag tggtggaaaa gctttattgg      120

acctactaca tacatttacc cttttattta atggcctctt ttgattcatt cttcctccat      180

gttttttttc tcacaatttt cagtttgagt ttcttcggta tactaaagta ttgcttcctt      240

tga                                                                    243


<210>  28
<211>  2328
<212>  DNA
<213>  Pichia pastoris

<400>  28
atgcagtacg taggtagagc cattggatca gtatccaaaa cctggtcgtc cattaacccg       60

gccacactga gtggtgctat tgatatcatc gtggtggaac aagaaaatgg tgatctggct      120

tgctctccct tccatgttcg gtttggaaag tttcaattat tgaggccttc ccaaaagaaa      180

gtggatttca tcgtcaatgg agaaaagaca gacttaccaa tgaaactggg cgatgggggc      240

gaagctttct ttgtgtttga aaccgatgct gccatcccga gtgagcttca aacttccccc      300

gtcatctcac ctgtatccag cccagaacca gcctctccac tgagtactcc ttccagacca      360

aactctgaac cagattattt agaattaggg gatggagaat ctacaaccag tgaattagag      420

aacttcaagt taaatcgata tccctattta tcaactgagg tatcgcattc agatcctggt      480

gttgggtctg tgagctcaag tcctgagaat acgaagatta ttcaaaagat ctctcggaaa      540

ctcaatacga aaaatattcc ttccaaggtt gataataacg gaaatcttgt attggatata      600

caaggttaca aaagtgatga tctagacgac aattccaaat ctttgaaaca gttgttattg      660

gctgaactcg gagaagatgt agatttggac aaggttattg aaaaagatca cgaaggaaac      720

attatgatca atggtgccat atctttgttg agcggagaag atgatctgga atcatttcct      780

cagaccgacg accaagctga gagtctcaaa ttggatctgg agtcagataa atctgacatt      840

gaatcagaca caaatcatga attgtctcgc tacttcaaaa cgctaagact tacatcagat      900

caattgaaat gtcttacact gaagaaggga attaacgagc tgaaattcag tgtcaacaag      960

ggcaaatctg tggtgacggc aaatctatac ttctgggact attatgaccc catagtcata     1020

tcggatatag atggaaccat tactaaatct gatgccttag gccatgtatt taccatgatt     1080

ggccgtgatt ggactcacaa aggtgtagcc aaattatttt cagatatcaa atccaatgga     1140

tacaatatca tgtatttgac tgcaaggtct gttggtcaag ccgattcgac ccgctactat     1200

ttaaacaaca ttgaacaaga aggcttgagg cttcctcaag ggccggtgat cctttctccg     1260

gatcgcacaa tggccgcttt acgaagagag gtaattttga agaaacctga ggtgttcaag     1320

atggcatgtt taaacgacat aaagaaactg tatctcacca ataccaaaga cctaaatccg     1380

aacacagatt ctgcagattt cacggatatc aatacgaaca ctttgagatc ttcaagtctt     1440

acagaggatg tacaaacgcc attttacgcc ggttttggta atagaattac cgatgctttg     1500

tcctataggt cagtagggat accatcatca agaattttta ccataaaccc agacggtgat     1560

gttcacatgg agctactcga attggctggg tatagaagtt cttatgtaca tattagtgag     1620

ctggtagatc atttctttcc accagtgaac actgaactat ttaagtcgat gccttctgat     1680

acctatcgga acacggcaaa gttctctgat gtcaattatt ggaaagagcc tttgtacaat     1740

tttgaggagc tcagtgatga agattctagt gaagatgagc taagaagaag aaaggaggag     1800

gaacgtttac agtctgctcc tcgtagtcca atattggcag caggagcatc gtttttcaaa     1860

ggaagtagta gccttttagg ttcaccagaa cggatgactt tgagtgaccc aaagccaact     1920

gaagttgccc ctagcacaat caaaccccca aaatcagttg gttctgtatc atccgatgaa     1980

gaaaagctga aagatcatga tgatttcatt gacgttgatc acgaagatga aaccttggat     2040

gatgatgacg atccctttga ctacgattac gagtatgaag atgaagaaga ggaaaatgac     2100

gacgtagatg aagttgatga tggggaagag tattcagatg attattatga cgaagaagac     2160

gactacgatg aagaattaga tcatacttta gaaccagacc aaaagaaaga actggaccaa     2220

acagctgaag ccaaccagtt acccccttca ggacccgatg aaatggaatc aaaatctttc     2280

aagaaagcca gtgatttaat aagcaaaatg agaatcgatg acagctga                  2328


<210>  29
<211>  942
<212>  DNA
<213>  Pichia pastoris

<400>  29
atgaagctct ccaccaattt gattctagct attgcagcag cttccgccgt tgtctcagct       60

gctccagttg ctccagccga agaggcagca aaccacttgc acaagcgtgc ttactacacc      120

gacacaacca agactcacac tttcactgag gttgttactg tctaccgaac tttgaaaccg      180

ggcgaaagta tcccaactga ctctccaagc cacggtggta aaagtactaa aaagggtaag      240

ggtagtacca ctcactctgg tgctccagga gctacctctg gtgctccaac tgacgacacc      300

acttcgacta gtggctcagt agggttacca actagcgcaa cttcagttac ctcttctacc      360

tcctctgcaa gtacaacaag cagtggaact tcagccacta gcactggtac cggtactagc      420

actagcacta gcactggtac tggtactggt actacaggca caggaaccac tagttccagc      480

actagctctt ctgctacttc gactccaacc ggttctatcg acgctatcag ccagacactt      540

ctggatactc acaatgataa gcgtgctttg cacggcgtcc cagaccttac ttggtctacc      600

gaactcgctg actacgccca aggttacgcc gattcataca cttgtggctc ttcattagaa      660

cacacaggtg gaccatacgg tgaaaatttg gcctctggat actctcctgc tggcagtgta      720

gaagcatggt acaacgagat cagcgactac gatttctcta acccaggtta ttctgctggt      780

accggtcact tcacccaagt tgtctggaaa tcaactacac agctgggctg tggatacaag      840

gagtgcagta ccgacagata ctacatcatc tgcgaatacg cacctcgtgg aaatattgtt      900

tctgccggct acttcgaaga caacgtcctg cctcctgttt ga                         942


<210>  30
<211>  1548
<212>  DNA
<213>  Pichia pastoris

<400>  30
atgagtctgg tccaggagtt gattcaaaag ataagctctt tggagctcac cttggtggaa       60

aagctttcca tcctgttcgt agctcccttc ttgttgaacg cgctatggca gtttatctac      120

agtttcagaa aggacagagt tcctttggta ttccactggg ttccatgggt aggctcagca      180

gtcacatatg gaatgcaacc atatgaattt tttgcagact gtcaaagaaa atacggagac      240

gtgtttgcct ttgttttgtt gggtaaagtt atgacagtgt acctcggacc aaaaggccat      300

gagtttattt taaatgctaa actaaacgac gtttgtgctg aagatgccta caagcacctg      360

accactcctg tatttggtga aggtgttatt tacgattgtc ccaactggaa gttgatggac      420

cagaagaagt ttgttaaagg atctttaacc aaggagtcct tcagatctta tgtccctaag      480

attagagatg aagtcctgga ttacatcaat aatgacccta acttcatggg aggtgattct      540

aaaaagaaaa ctggaaagac caatgtcctg aactctcagt ccgagcttac gatcttgacc      600

gcttccagat ctctactggg agatgatatg agaaaactac tgactaagaa atgggctaaa      660

ctgtttagtg acctagacaa aggatttact cctttaaact tcattttctc tcatcttcct      720

ctaccaagtt actggactcg tgatcatgct caaaagacca tttctgagac ttatttatct      780

ttgattaaca agagaagagc tacaaacgac attggtgaca gagatttgat cgattcatta      840

atgaaatctt ctacatacaa agatggtagc aagatgaccg acgaggagat ttcccacttg      900

ttaatcggag ttcttatggg tggccagcac acttctgcct ccacttcatc gtggtttttg      960

ttgcatctcg gagagaaacc agagctgcag gaggaattat ttgaagaaca ggaaagggta     1020

cttcaagggc gtgagttgac ttatgacgat cttgctaata tgcctttaca caatcaagtc     1080

atcaaggaaa ctttgcgcat gcacatgcct ctacactcaa tctttagaaa ggtcactcgt     1140

cctcttcccg ttcctaactc aaagtatgtg gttcctaagg gtcattatgt attggtttca     1200

cctggatttg ccatgaccaa cgatgcgtac ttcccaaacg ctagtgactt ccagccacac     1260

agatgggatg aaactgttga accagtctca gctgacgcaa aggaaactgt tgactacgga     1320

tttggtaaag tctccaaagg tgtttcttct ccttacttac catttggagg aggaagacat     1380

agatgtattg gcgaacattt tgcgtactgt cagttaggaa ccatcttgaa cacattcgtt     1440

agaaccttca agtggaaggc cgtagtccct cagccggact atacctcaat ggttactctt     1500

cctgaaccta atttgtctac tattacatgg gaaagacgcg ataattag                  1548


<210>  31
<211>  2961
<212>  DNA
<213>  Pichia pastoris

<400>  31
atgcttactg ggttgtccaa gatatgtgcg catagaccaa tccataccat agtggtgacc       60

gctctcttag tttccttagc atacctaacc attgtggagg agtacacatc gagatcttca      120

ttatccaatc cttttatatc gttttaccac ccaccaggaa acagtgatta ccaaaattgg      180

attccagtgg atgactctgt gaagctcaaa agcaagtcag cccagcatct ctctgtatgc      240

gctttgaagt ttaaaagggt taatggacat cagattcccg atctggcagg aagttttcag      300

agcgcagacc caactgaaat atttgtcgtt caggattttg acaaatcatt tgactatttt      360

gattcaattt caaccattga gggtaaggat ggcatccaat ggaaagtcag acaccccaat      420

aggttgggac gttattctga gtacttcaga tctgtttttt caaaaacttt gagactggtt      480

cagggtgctg aaccattcga cattgtgctt attgcttttg cttacgttgc tatgtggtac      540

acatttttgc agctctatta tgaaatgaaa acaaaggcca actctaactt ttggctgact      600

ttcggctctc tgctgtcttc aggttgtgca tttgtgtttg cattggccgt cactgtaaaa      660

gtatacggta tcaaggttcc actcacatct ttaactgaag gtgtcccatt tttggtagct      720

accattggtt tcaaacacaa agttgcattc actgttccta ttctccaagc ttcccgttca      780

aaaaaagcca aagaaattcc tgacaccatt atttcagtga ttgaacaaac cacagggtgg      840

cctctgatta aggatcatct cattatgatt tccgccttct tagcatgttc tttttatgcc      900

ccccgtatgg aaggactcaa aaacttttgc attctctccg ctaatatctt aacgtttgac      960

cttataatga ttttcacatt ttttaccgct gtattatctt taaaagctca gattaataag     1020

gttcacgaaa caactgcttt gcagcaagtt ctggaggaag atggaattgc tgaagatgtt     1080

gctgaacgca ttgctgcttc aaaccgaaat atgttttccc gtagtaccag cgtcgtcagc     1140

ttcaaagtga taatgatcgc tgggttcctt ggattccatt tatttgtgtt gggaacttca     1200

tggctctatg actctgacgt ttcaagctct tctatatttg gtaagagcaa tgtatctgcc     1260

ttatccaaag ctgctgccaa acatattcct attggatccg aaggaactat tgtgaccatt     1320

atgcctacga gggtttacat gcctgttgat ttacttctaa agttggaaga tgattttctg     1380

aacatttttt ccaagatatc ggctagcata actgatcctt tgattagcaa acttcttttc     1440

ataattaccg gaataagtgc cacaatcaac gtttacttgt tgaatgctgc tcgattccac     1500

tcgtctagag aaattgctgt ctctacaatt gcaaagcctc aaacgccaga cgttgttccc     1560

acagtagaac cgcttccaaa tgaaaatgac acaagcattc gaccattgga ggagatggtt     1620

tcattgctga aggaaggtaa aacacgagag ctgaacaatg atgaggtatc atctctcgtt     1680

gttcaaggaa aacttccctt gtacgcccta gaaaaacaac ttgttgataa gacccgcgca     1740

gttattgtaa gaaggaaggc aattgcttcc ttagcagatg ctccggtctt gagaaccgaa     1800

aagctgcctt acaaagatta tgattatgac cgtgtatttg gcgcttgttg tgagaatgtt     1860

atcggattca tgcccttacc agtcggcgtt gctggtccct tgatcattga cggtaaacct     1920

tatcacattc ccatggctac tactgaaggc tgcttagtag cctcaaccat gagaggttgt     1980

aaagctatca attctggagg cggtgtagaa actgttctga cagccgacgg aatgacaaga     2040

ggaccatgcg tttctttccc atctctttct cgtgcaggtg cagctaagat gtggctagat     2100

agtgaagaag ggcaaaagac cattaagggt gcgtttaact ccacctctag atttgcccgt     2160

ttgcagcatg ttaagacaac ccttgctggt acattattgt tcatccgatt caagactact     2220

actggtgatg cgatgggtat gaacatgatt tctaagggtg tggagtattc actaaagttt     2280

atgtcggaag aatgtgactg gcctgacatg gaagttattt ctgtttcagg taattactgt     2340

acagacaaaa aagttgctgc aatcaactgg atcgaaggtc gtggtaagtc tgtcgttgct     2400

gaagctcgta ttccagccga tgttgtcaga agcgttctga agtccgatgt tgaggcattg     2460

gtagaattga atgttagcaa gaacttgatt ggatccgcaa tggcaggatc aattggtggt     2520

ttcaacgcac aagctgccaa tctagttaca gcagtatact tagctacagg acaggatcca     2580

gcccagaatg tcgaaagttc caactgtatt accttgatga acaagctccc aaatggagat     2640

ttacaaattt cagtctctat gccatctatc gaagttggaa ccattggtgg aggaaccgtt     2700

ttggaacctc aaggatcaat gttggaacta ttaggagtta aaggtcctca cccaactaat     2760

ccaggtgcaa actcaaggca gttggctaag atcgttgctt ctgctgtctt ggctgcagag     2820

ctgtccttgt gctctgccct tgcagctggt cacttagtcc aaagtcatat gacccataac     2880

agaaagcaag ctccagtcaa ggaggtaaac ggcactgccg ctaggctagc ggaacaatct     2940

aagatttgca ttaaatcttg a                                               2961


<210>  32
<211>  1422
<212>  DNA
<213>  Pichia pastoris

<400>  32
atgacgccag acgttgttcc cacagtagaa ccgcttccaa atgaaaatga cacaagcatt       60

cgaccattgg aggagatggt ttcattgctg aaggaaggta aaacacgaga gctgaacaat      120

gatgaggtat catctctcgt tgttcaagga aaacttccct tgtacgccct agaaaaacaa      180

cttgttgata agacccgcgc agttattgta agaaggaagg caattgcttc cttagcagat      240

gctccggtct tgagaaccga aaagctgcct tacaaagatt atgattatga ccgtgtattt      300

ggcgcttgtt gtgagaatgt tatcggattc atgcccttac cagtcggcgt tgctggtccc      360

ttgatcattg acggtaaacc ttatcacatt cccatggcta ctactgaagg ctgcttagta      420

gcctcaacca tgagaggttg taaagctatc aattctggag gcggtgtaga aactgttctg      480

acagccgacg gaatgacaag aggaccatgc gtttctttcc catctctttc tcgtgcaggt      540

gcagctaaga tgtggctaga tagtgaagaa gggcaaaaga ccattaaggg tgcgtttaac      600

tccacctcta gatttgcccg tttgcagcat gttaagacaa cccttgctgg tacattattg      660

ttcatccgat tcaagactac tactggtgat gcgatgggta tgaacatgat ttctaagggt      720

gtggagtatt cactaaagtt tatgtcggaa gaatgtgact ggcctgacat ggaagttatt      780

tctgtttcag gtaattactg tacagacaaa aaagttgctg caatcaactg gatcgaaggt      840

cgtggtaagt ctgtcgttgc tgaagctcgt attccagccg atgttgtcag aagcgttctg      900

aagtccgatg ttgaggcatt ggtagaattg aatgttagca agaacttgat tggatccgca      960

atggcaggat caattggtgg tttcaacgca caagctgcca atctagttac agcagtatac     1020

ttagctacag gacaggatcc agcccagaat gtcgaaagtt ccaactgtat taccttgatg     1080

aacaagctcc caaatggaga tttacaaatt tcagtctcta tgccatctat cgaagttgga     1140

accattggtg gaggaaccgt tttggaacct caaggatcaa tgttggaact attaggagtt     1200

aaaggtcctc acccaactaa tccaggtgca aactcaaggc agttggctaa gatcgttgct     1260

tctgctgtct tggctgcaga gctgtccttg tgctctgccc ttgcagctgg tcacttagtc     1320

caaagtcata tgacccataa cagaaagcaa gctccagtca aggaggtaaa cggcactgcc     1380

gctaggctag cggaacaatc taagatttgc attaaatctt ga                        1422


<210>  33
<211>  1515
<212>  DNA
<213>  Pichia pastoris

<400>  33
atgggaataa gtgccacaat caacgtttac ttgttgaatg ctgctcgatt ccactcgtct       60

agagaaattg ctgtctctac aattgcaaag cctcaaacgc cagacgttgt tcccacagta      120

gaaccgcttc caaatgaaaa tgacacaagc attcgaccat tggaggagat ggtttcattg      180

ctgaaggaag gtaaaacacg agagctgaac aatgatgagg tatcatctct cgttgttcaa      240

ggaaaacttc ccttgtacgc cctagaaaaa caacttgttg ataagacccg cgcagttatt      300

gtaagaagga aggcaattgc ttccttagca gatgctccgg tcttgagaac cgaaaagctg      360

ccttacaaag attatgatta tgaccgtgta tttggcgctt gttgtgagaa tgttatcgga      420

ttcatgccct taccagtcgg cgttgctggt cccttgatca ttgacggtaa accttatcac      480

attcccatgg ctactactga aggctgctta gtagcctcaa ccatgagagg ttgtaaagct      540

atcaattctg gaggcggtgt agaaactgtt ctgacagccg acggaatgac aagaggacca      600

tgcgtttctt tcccatctct ttctcgtgca ggtgcagcta agatgtggct agatagtgaa      660

gaagggcaaa agaccattaa gggtgcgttt aactccacct ctagatttgc ccgtttgcag      720

catgttaaga caacccttgc tggtacatta ttgttcatcc gattcaagac tactactggt      780

gatgcgatgg gtatgaacat gatttctaag ggtgtggagt attcactaaa gtttatgtcg      840

gaagaatgtg actggcctga catggaagtt atttctgttt caggtaatta ctgtacagac      900

aaaaaagttg ctgcaatcaa ctggatcgaa ggtcgtggta agtctgtcgt tgctgaagct      960

cgtattccag ccgatgttgt cagaagcgtt ctgaagtccg atgttgaggc attggtagaa     1020

ttgaatgtta gcaagaactt gattggatcc gcaatggcag gatcaattgg tggtttcaac     1080

gcacaagctg ccaatctagt tacagcagta tacttagcta caggacagga tccagcccag     1140

aatgtcgaaa gttccaactg tattaccttg atgaacaagc tcccaaatgg agatttacaa     1200

atttcagtct ctatgccatc tatcgaagtt ggaaccattg gtggaggaac cgttttggaa     1260

cctcaaggat caatgttgga actattagga gttaaaggtc ctcacccaac taatccaggt     1320

gcaaactcaa ggcagttggc taagatcgtt gcttctgctg tcttggctgc agagctgtcc     1380

ttgtgctctg cccttgcagc tggtcactta gtccaaagtc atatgaccca taacagaaag     1440

caagctccag tcaaggaggt aaacggcact gccgctaggc tagcggaaca atctaagatt     1500

tgcattaaat cttga                                                      1515


<210>  34
<211>  1383
<212>  DNA
<213>  Pichia pastoris

<400>  34
atgcctgaaa agaagaacag tcgttccgct gacgaagctc ttagctttct tgctaaaacg       60

aacgtagagc gcccgatgca ttactctaag acagggaaca taacgcccga cacggtatct      120

tcaagagaag atcactacca agattacgac gactcacaag atgacattat aaataacaaa      180

ctattacaaa gaagacaggg tgggccacac aacaagatag agaagcaaag gaggtttgct      240

ttgttgagga gttccctaaa caggagattg gaaactctag taatattgtg gcatactatc      300

acgattccat ttttagcatc actatttttc gttctgtgta caattcccat gttgtggcct      360

cttataatag tttacttggt ttatttttac atcgatgcca atactccaag caatggaaag      420

tctgctgacc gaagagtgga atggttcaga agtttgcata tttggaaaca ttttgtcaat      480

tattacccta tatctgtgta caaaactgtt gacctggaac cgacgttcaa gactaagaag      540

attgaaatta ttcttccgaa gtatcaccaa gtaaccactt atttgccaag ttctgttaga      600

aagtacatac cgacacacag agttctcata gaaaaggaga tcaaaacagg gccaagatac      660

atatttggtt atcaccctca tggggtagtt tccctgggga tcactggagc ttttggcacc      720

aatggttgta acattggcga gttactacca ggaatcagaa tatatttatt aaccctcatc      780

actcaattca aacttcctct attgagagat tacttaatgg cattgggtat ttcttctgtt      840

tcgaaacgta atgtgactgc actgataaaa cgaaatcagt ctgtctgtat tgtcattgga      900

ggtgcttcgg agtccctatt atccaaacca catactattg atattgtcct gaaaaaaagg      960

aaaggctttg tgaaagtcgc actagagctg ggtgacactg agttagttcc agtatttggt     1020

tttggagaaa acactgccta taatgttttt gacccaagtg tatctggcaa gtcttgctct     1080

gtcctaaatt acgtgcggaa gcaaatgtgt gggtttcaat tatggttaaa acaacacttt     1140

ggctttacct ttccattttt tcatgctagg ggtgttttca atcacgactt tggccttcta     1200

ccatatcgga aacctatcaa cttggtcatc ggtagaccca tcccggttcc ttacattcat     1260

tcaccaaccc aagaacagat tgaccattac cattccctat atgtcgaaga actgaaacga     1320

gtttttgagc agaataagga gaggtttaat gctggatcct tggagctacg aattgtcgag     1380

tga                                                                   1383


<210>  35
<211>  1959
<212>  DNA
<213>  Pichia pastoris

<400>  35
atgcaactac ggaaaagagg aaacgagaga tccagacttg aatcgcacat cggcgattcg       60

gacacggtta ttgacttgga tgactcttca gtaaacgaca cgcttccgga tgaagacaac      120

atcgctaaac caagaaaagc gtcaacgcac agaagaccat cacttcgaaa aatccacagc      180

gctgagactg tccgtcgttt ctatgagtca aagaatgtaa tttttatttt tggagccttc      240

ataggaatcg ctgttgcttt gtactttgga gctaccagtt ctgagtaccc tattccagac      300

atagatcaac tggtcaactt tgactctctt tccacctatt ttgacgattg gaaggatgtc      360

ttaccaaagt cccttcaaag tattgttgag agtactcagt tcaatcagaa ttctaagata      420

ttgagctctg aatcatttgc agtaggtaag caattgaaga gtaagtcaat gattgaagct      480

aatcattcca ttgttcttgt tcctggtgtg atcagcaccg ggctggaaag ttggggcttg      540

gaaggaactc ctgactgccc ctccgaaggt cattttagaa aacgtctatg gggatcattt      600

tacatgttgc ggacaatgtt tttggataag gcgtgttggc tgaaacatat tatgctagat      660

acaacaacgg gattagaccc tccaggaata agcctcagag cagctcaggg gtttgaagct      720

gctgatttct ttatagcagg ttactggatt tggaataaaa tccttcagaa cttggcagtt      780

attggatata atccaaacaa catggtgagc gctgcttatg attggagact tgcttttctg      840

gatttagaat tacgggatgc atacttttca aaattaaaag gtttcgttga acttcaaaag      900

catcagagtg ggaaaaaatc ggttttggta ggtcattcaa tggggtcaca agtgatttac      960

tattttatga agtgggttga agctgacgga tacggaaacg gaggccctaa ctgggtgaat     1020

gatcatgtag attcttttgt ggacatatcc ggctgtatgc tgggtactcc taaggctata     1080

cctgctcttt tatccggaga aatgaaggat acagttcaat taaacgccct cgccgtggag     1140

ggcttagaaa agtttctgtc tagaagagaa cgtgctgata tgatccgttc ttttggtgga     1200

atagccagca tgattcccaa aggcggagat ctaatctggg gaaatctcga gagttctcct     1260

gatgacgcca cgtcaattgg agatttggga aacgacactt atggtaattt cattaggttc     1320

aaggagccgg tggggaagta ctcccaaaag aacttaacgg tgactgatag tattcagttt     1380

ttgatggagc agactcccgc ctggttccaa gacaggatgt tgagggctta ctcttatggg     1440

ttcaccaatt ctgctaagca gctgaaaaaa aataataaag atcatacaaa atggtccaat     1500

ccccttgagg catcacttcc aaatgcacct gatctgaaag tgttttgctt ttatgggttt     1560

ggaaatccta cagaaagagc ttactactac cgagaagaag ttgatccggc taagaccaaa     1620

ttgaacgtca ctattgaaaa gaactatgat tcggttctta tggcagatgg tgacggtacg     1680

gtcagtctaa tgactcactc aatgtgccac atatggaagc aagctaatag tgtttacaac     1740

ccaggaaata gcaaggtcaa gattgttgag attgatcatg aacctgatcg gtttgacatt     1800

cgaggaggtg ccaaaactgc tgaacatgta gacattctgg gatctgcaga gttaaacgag     1860

ctagtgttac tggtggccgc tggaaaggga gaccaaatta aggaaaagat tgttagtaat     1920

ctgaaggaaa tagttgataa tcttgaacta gatctttaa                            1959


<210>  36
<211>  2037
<212>  DNA
<213>  Pichia pastoris

<400>  36
atgctgtcgt taaaaccatc ttggctgact ttggcggcat taatgtatgc catgctattg       60

gtcgtagtgc catttgctaa acctgttaga gctgacgatg tcgaatctta tggaacagtg      120

attggtatcg atttgggtac cacgtactct tgtgtcggtg tgatgaagtc gggtcgtgta      180

gaaattcttg ctaatgacca aggtaacaga atcactcctt cctacgttag tttcactgaa      240

gacgagagac tggttggtga tgctgctaag aacttagctg cttctaaccc aaaaaacacc      300

atctttgata ttaagagatt gatcggtatg aagtatgatg ccccagaggt ccaaagagac      360

ttgaagcgtc ttccttacac tgtcaagagc aagaacggcc aacctgtcgt ttctgtcgag      420

tacaagggtg aggagaagtc tttcactcct gaggagattt ccgccatggt cttgggtaag      480

atgaagttga tcgctgagga ctacttagga aagaaagtca ctcatgctgt cgttaccgtt      540

ccagcctact tcaacgacgc tcaacgtcaa gccactaagg atgccggtct catcgccggt      600

ttgactgttc tgagaattgt gaacgagcct accgccgctg cccttgctta cggtttggac      660

aagactggtg aggaaagaca gatcatcgtc tacgacttgg gtggaggaac cttcgatgtt      720

tctctgcttt ctattgaggg tggtgctttc gaggttcttg ctaccgccgg tgacacccac      780

ttgggtggtg aggactttga ctacagagtt gttcgccact tcgttaagat tttcaagaag      840

aagcataaca ttgacatcag caacaatgat aaggctttag gtaagctgaa gagagaggtc      900

gaaaaggcca agcgtacttt gtcttcccag atgactacca gaattgagat tgactctttc      960

gtcgacggta tcgacttctc tgagcaactg tctagagcta agtttgagga gatcaacatt     1020

gaattattca agaagacact gaaaccagtt gaacaagtcc tcaaagacgc tggtgtcaag     1080

aaatctgaaa ttgatgacat tgtcttggtt ggtggttcta ccagaattcc aaaggttcaa     1140

caattattgg aggattactt tgacggaaag aaggcttcta agggaattaa cccagatgaa     1200

gctgtcgcat acggtgctgc tgttcaggct ggtgttttgt ctggtgagga aggtgtcgat     1260

gacatcgtct tgcttgatgt gaacccccta actctgggta tcgagactac tggtggcgtt     1320

atgactacct taatcaacag aaacactgct atcccaacta agaaatctca aattttctcc     1380

actgctgctg acaaccagcc aactgtgttg attcaagttt atgagggtga gagagccttg     1440

gctaaggaca acaacttgct tggtaaattc gagctgactg gtattccacc agctccaaga     1500

ggtactcctc aagttgaggt tacttttgtt ttagacgcta acggaatttt gaaggtctct     1560

gccaccgata agggaactgg aaaatccgag tccatcacca tcaacaatga tcgtggtaga     1620

ttgtccaagg aggaggttga ccgtatggtt gaagaggccg agaagtacgc cgctgaggat     1680

gctgcactaa gagaaaagat tgaggctaga aacgctctgg agaactacgc tcattccctt     1740

aggaaccaag ttactgatga ctctgaaacc gggcttggtt ctaaattgga cgaggacgac     1800

aaagagacat tgacagatgc catcaaagat accctagagt tcttggaaga caacttcgac     1860

accgcaacca aggaagaatt agacgaacaa agagaaaagc tttccaagat tgcttaccca     1920

atcacttcta agctatacgg tgctccagag ggtggtactc cacctggtgg tcaaggtttt     1980

gacgatgatg atggagactt tgactacgac tatgactatg atcatgatga gttgtag        2037


<210>  37
<211>  312
<212>  PRT
<213>  Pichia pastoris

<400>  37

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser His Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Trp Val Ala Asn Ile Glu Gln Asp Gly Ser Glu Lys Tyr 
    130                 135                 140                 


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
145                 150                 155                 160 


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Phe Cys Ala Arg Asp Leu Glu Gly Leu His Gly Asp Gly 
            180                 185                 190         


Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala 
        195                 200                 205             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
    210                 215                 220                 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
225                 230                 235                 240 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                245                 250                 255     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            260                 265                 270         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
        275                 280                 285             


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    290                 295                 300                 


Val Glu Ser Lys Tyr Gly Pro Pro 
305                 310         


<210>  38
<211>  299
<212>  PRT
<213>  Pichia pastoris

<400>  38

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
                85                  90                  95      


Ser Ala Ser Val Gly Asp Arg Val Ile Leu Thr Cys Arg Ala Ser Gln 
            100                 105                 110         


Gly Val Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        115                 120                 125             


Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro 
    130                 135                 140                 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Pro Asp Phe Thr Leu Thr Ile 
145                 150                 155                 160 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Phe 
                165                 170                 175     


Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            180                 185                 190         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        195                 200                 205             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    210                 215                 220                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
225                 230                 235                 240 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                245                 250                 255     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            260                 265                 270         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        275                 280                 285             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    290                 295                 


<210>  39
<211>  303
<212>  PRT
<213>  Pichia pastoris

<400>  39

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu 
                85                  90                  95      


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp 
            100                 105                 110         


Ser Ile Thr Ser Asp Tyr Trp Ser Trp Ile Arg Lys Phe Pro Gly Asn 
        115                 120                 125             


Arg Leu Glu Tyr Met Gly Tyr Val Ser Tyr Ser Gly Ser Thr Tyr Tyr 
    130                 135                 140                 


Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
145                 150                 155                 160 


Asn Gln Tyr Tyr Leu Asp Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 
                165                 170                 175     


Thr Tyr Tyr Cys Ala Asn Trp Asp Gly Asp Tyr Trp Gly Gln Gly Thr 
            180                 185                 190         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        195                 200                 205             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    210                 215                 220                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
225                 230                 235                 240 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                245                 250                 255     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            260                 265                 270         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        275                 280                 285             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    290                 295                 300             


<210>  40
<211>  299
<212>  PRT
<213>  Pichia pastoris

<400>  40

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
                85                  90                  95      


Ser Val Thr Pro Gly Asn Ser Val Ser Leu Ser Cys Arg Ala Ser Gln 
            100                 105                 110         


Ser Ile Gly Asn Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser 
        115                 120                 125             


Pro Arg Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro 
    130                 135                 140                 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile 
145                 150                 155                 160 


Asn Ser Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser 
                165                 170                 175     


Asn Ser Trp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            180                 185                 190         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        195                 200                 205             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    210                 215                 220                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
225                 230                 235                 240 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                245                 250                 255     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            260                 265                 270         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        275                 280                 285             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    290                 295                 


<210>  41
<211>  939
<212>  DNA
<213>  Pichia pastoris

<400>  41
atgagattcc catctatttt caccgctgtc ttgttcgctg cctcctctgc attggctgcc       60

cctgttaaca ctaccactga agacgagact gctcaaattc cagctgaagc agttatcggt      120

tactctgacc ttgagggtga tttcgacgtc gctgttttgc ctttctctaa ctccactaac      180

aacggtttgt tgttcattaa caccactatc gcttccattg ctgctaagga agagggtgtc      240

tctctcgaga agagagaggt ccaattggtc caatctggtg gaggattggt tcaaccaggt      300

ggatctctga gattgtcttg tgctgcttct ggtttcacct tctctcacta ctggatgtca      360

tgggttagac aagctcctgg taagggtttg gaatgggttg ctaacatcga gcaagatgga      420

tcagagaagt actacgttga ctctgttaag ggaagattca ctatttcccg tgataacgcc      480

aagaactcct tgtacctgca aatgaactcc cttagagctg aggatactgc tgtctacttc      540

tgtgctagag acttggaagg tttgcatggt gatggttact tcgacttatg gggtagaggt      600

actcttgtca ccgtttcatc tgcctctacc aaaggacctt ctgtgttccc attagctcca      660

tgttccagat ccacctccga atctactgca gctttgggtt gtttggtgaa ggactacttt      720

cctgaaccag tgactgtctc ttggaactct ggtgctttga cttctggtgt tcacaccttt      780

cctgcagttt tgcagtcatc tggtctgtac tctctgtcct cagttgtcac tgttccttcc      840

tcatctcttg gtaccaagac ctacacttgc aacgttgacc ataagccatc caataccaag      900

gttgacaaga gagttgagtc caagtatggt ccaccttaa                             939


<210>  42
<211>  900
<212>  DNA
<213>  Pichia pastoris

<400>  42
atgagattcc catctatttt caccgctgtc ttgttcgctg cctcctctgc attggctgcc       60

cctgttaaca ctaccactga agacgagact gctcaaattc cagctgaagc agttatcggt      120

tactctgacc ttgagggtga tttcgacgtc gctgttttgc ctttctctaa ctccactaac      180

aacggtttgt tgttcattaa caccactatc gcttccattg ctgctaagga agagggtgtc      240

tctctcgaga agagagctat ccagttgact caatcaccat cctctttgtc tgcttctgtt      300

ggtgatagag tcatcctgac ttgtcgtgca tctcaaggtg tttcctcagc tttagcttgg      360

taccaacaaa agccaggtaa agctccaaag ttgctgatct acgacgcttc atcccttgaa      420

tctggtgttc cttcacgttt ctctggatct ggatcaggtc ctgatttcac tctgactatc      480

tcatcccttc aaccagaaga ctttgctacc tacttctgtc aacagttcaa ctcttaccct      540

ttgacctttg gaggtggaac taagttggag atcaagagaa ctgttgctgc accatcagtg      600

ttcatctttc ctccatctga tgagcaactg aagtctggta ctgcatctgt tgtctgctta      660

ctgaacaact tctacccaag agaagctaag gtccaatgga aggttgacaa tgccttgcaa      720

tctggtaact ctcaagagtc tgttactgag caagactcta aggactctac ttactccctt      780

tcttccacct tgactttgtc taaggctgat tacgagaagc acaaggttta cgcttgtgag      840

gttactcacc aaggtttgtc ttctcctgtt accaagtctt tcaacagagg tgaatgctaa      900


<210>  43
<211>  915
<212>  DNA
<213>  Pichia pastoris

<400>  43
atgagattcc catctatttt caccgctgtc ttgttcgctg cctcctctgc attggctgcc       60

cctgttaaca ctaccactga agacgagact gctcaaattc cagctgaagc agttatcggt      120

tactctgacc ttgagggtga tttcgacgtc gctgttttgc ctttctctaa ctccactaac      180

aacggtttgt tgttcattaa caccactatc gcttccattg ctgctaagga agagggtgtc      240

tctctcgaga agagagacgt tcaattgcaa gaatctggtc catccttggt taagccatcc      300

cagactttgt ccttgacttg ttccgttact ggtgactcca tcacttctga ctactggtcc      360

tggatcagaa agttcccagg taacagattg gagtacatgg gttacgtttc ttactccggt      420

tccacttact acaacccatc cttgaagtcc agaatctcca tcactagaga cacttccaag      480

aaccagtact acttggactt gaactccgtt actactgagg acactgctac ttactactgt      540

gctaactggg acggtgacta ttggggtcaa ggtactttgg ttactgtttc ctccgcttcc      600

actaagggtc catctgtttt tccattggct ccatcctcca agtctacttc aggtggtact      660

gctgctttgg gttgtttggt taaggactac ttcccagagc cagttactgt ttcttggaac      720

tccggtgctt tgacttccgg tgttcacact ttcccagctg tcttgcaatc ctccggtctg      780

tactccttgt cctccgttgt tactgttcct tcttcctcct tgggtactca aacttacatc      840

tgtaacgtta accacaagcc atccaacact aaggttgaca agagagttga gccaaagtcc      900

tgtgacaagt aatag                                                       915


<210>  44
<211>  903
<212>  DNA
<213>  Pichia pastoris

<400>  44
atgagattcc catctatttt caccgctgtc ttgttcgctg cctcctctgc attggctgcc       60

cctgttaaca ctaccactga agacgagact gctcaaattc cagctgaagc agttatcggt      120

tactctgacc ttgagggtga tttcgacgtc gctgttttgc ctttctctaa ctccactaac      180

aacggtttgt tgttcattaa caccactatc gcttccattg ctgctaagga agagggtgtc      240

tctctcgaga agagagacat cgttttgact caatccccag ctactttgtc cgttactcca      300

ggtaactccg tttccttgtc ctgtagagct tcccagtcca tcggtaacaa cttgcactgg      360

tatcagcaga agtctcacga gtccccaaga ctgttgatca agtacgcttc ccaatccatc      420

tccggtatcc catctagatt ctctggttct ggttccggta ctgacttcac tttgtccatc      480

aactccgttg agactgagga cttcggtatg tacttctgtc agcaatccaa ctcctggcca      540

tacacttttg gtggtggtac taagttggag atcaagagaa ctgttgctgc tccatccgtt      600

ttcatcttcc caccatctga cgagcagttg aagtctggta ctgcttccgt tgtttgtttg      660

ttgaacaact tctacccaag agaagctaag gttcagtgga aggttgacaa cgccttgcaa      720

tccggtaact cccaagagtc cgttactgaa caagactcca aggactctac ttactccttg      780

tcctccactt tgactttgtc caaggctgac tacgagaagc acaaggttta cgcttgtgag      840

gttactcacc agggtttgtc ctccccagtt actaagtcct tcaacagagg tgagtgttaa      900

tag                                                                    903


<210>  45
<211>  85
<212>  PRT
<213>  Saccharomyces cerevisae

<400>  45

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  46
<211>  255
<212>  DNA
<213>  Saccharomyces cerevisae

<400>  46
atgagattcc catctatttt caccgctgtc ttgttcgctg cctcctctgc attggctgcc       60

cctgttaaca ctaccactga agacgagact gctcaaattc cagctgaagc agttatcggt      120

tactctgacc ttgagggtga tttcgacgtc gctgttttgc ctttctctaa ctccactaac      180

aacggtttgt tgttcattaa caccactatc gcttccattg ctgctaagga agagggtgtc      240

tctctcgaga agaga                                                       255


<210>  47
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  47
ctcgcctgca ggaccatgag tgacattaat actctgtcgc                             40


<210>  48
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  48
acggccgagg cggccagtta ggcacgacgg acactag                                37


<210>  49
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  49
tctacctgca ggaacgatgt ccattctctc atttg                                  35


<210>  50
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  50
tatggccgag gcggcctcag gccttgcgag agcgcaaatt tc                          42


<210>  51
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  51
atacctgcag gacaatgtct aaagaggaaa agacaag                                37


<210>  52
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  52
attggccgag gcggccctat tcttccttct tggagg                                 36


<210>  53
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  53
atacctgcag gacaatgggt gttgaaacat cttc                                   34


<210>  54
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  54
attggccgag gcggcctcaa gaactctcct catcatc                                37


<210>  55
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  55
atacctgcag gacaatgagc caacgtgaag                                        30


<210>  56
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  56
attggccgag gcggcctcaa agctgttgca aaac                                   34


<210>  57
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  57
atacctgcag gacaatgtca aaaactatcc cagatg                                 36


<210>  58
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  58
attggccgag gcggccttag tacatggctt tcttgc                                 36


<210>  59
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  59
ataccctgca ggcaccaatg gttaaactca ttg                                    33


<210>  60
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  60
ataggccgag gcggccctac aaaaggaatg g                                      31


<210>  61
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  61
ttccctgcag gaccatgtct caacccactc                                        30


<210>  62
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  62
acggccgagg cggcctcaca tgtgataaat tgtg                                   34


<210>  63
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  63
ttccctgcag ggaaatgaca caacataaaa gctcgatgg                              39


<210>  64
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  64
acggccgagg cggcctcaaa ggaagcaata ctttag                                 36


<210>  65
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  65
ttccctgcag gaccatgcag tacgtaggta g                                      31


<210>  66
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  66
tatggccgag gcggcctcag ctgtcatcga ttc                                    33


<210>  67
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  67
gaagctctcc accaatttg                                                    19


<210>  68
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  68
cgtcaaacag gaggcaggac                                                   20


<210>  69
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  69
tctcctgcag gcaaacatga gtctggtcca g                                      31


<210>  70
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  70
tatggccgag gcggccaact aattatcgcg tctttc                                 36


<210>  71
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  71
ttccctgcag gacgatgctt actgggttgt c                                      31


<210>  72
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  72
aggccgaggc ggcctcaaga tttaatgcaa atcttag                                37


<210>  73
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  73
taccctgcag gacgatggga ataagtgcca caatc                                  35


<210>  74
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  74
aggccgaggc ggcctcaaga tttaatgcaa atcttag                                37


<210>  75
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  75
ttccctgcag gacgatgacg ccagacgttg ttcc                                   34


<210>  76
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  76
aggccgaggc ggcctcaaga tttaatgcaa atcttag                                37


<210>  77
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  77
atacctgcag gacaatgctg tcgttaaaac catc                                   34


<210>  78
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  78
ataggccgag gcggccctac aactcatcat gatcatagtc                             40


<210>  79
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  79
agatatagtt ctgttttatt ccattagagg aggatccg                               38


<210>  80
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  80
gttgtcgacc tgcagcgtac tagatactgg cacataacac                             40


<210>  81
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  81
gtgttatgtg ccagtatcta gtacgctgca ggtcgacaac                             40


<210>  82
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  82
cggtgagaat ggcaaaagct tatg                                              24


<210>  83
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  83
aagcccgatg cgccagagtt g                                                 21


<210>  84
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  84
acctcctttg cttctctatc agtggatctg atatcaccta                             40


<210>  85
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  85
taggtgatat cagatccact gatagagaag caaaggaggt                             40


<210>  86
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  86
actaactcag tgtcacccag ctc                                               23


<210>  87
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  87
tcttgccatc ctatggaact g                                                 21


<210>  88
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  88
acagagcaag acttgccag                                                    19


<210>  89
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  89
actctagctg ttgtccgcca gttc                                              24


<210>  90
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  90
gttgtcgacc tgcagcgtac tatcaattgt gaacataatg                             40


<210>  91
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  91
cattatgttc acaattgata gtacgctgca ggtcgacaac                             40


<210>  92
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  92
cggtgagaat ggcaaaagct tatg                                              24


<210>  93
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  93
aagcccgatg cgccagagtt g                                                 21


<210>  94
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  94
gactcataga aacgacggaa gtggatctga tatcaccta                              39


<210>  95
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  95
taggtgatat cagatccact tccgtcgttt ctatgagtc                              39


<210>  96
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  96
attcacccag ttagggcctc cg                                                22


<210>  97
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  97
tcttgccatc ctatggaact g                                                 21


<210>  98
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  98
taggagtacc cagcatacag                                                   20


<210>  99
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  99
actacctgca ggcgaaacga tgagattccc atc                                    33


<210>  100
<211>  44
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  100
tcatggccga ggcggcccta ttacttgtca caggactttg gctc                        44


<210>  101
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  101
ctatggccga ggcggcccta ttaacactca cctctgttg                              39


<210>  102
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  102
tatcggccga ggcggcccta ttacttacct ggggacaag                              39


<210>  103
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  oligonucleotide for nucleic acid amplification

<400>  103
ctatggccga ggcggcccta ttaacactca cctctgttg                              39


