                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Bispecific antigen binding molecule for a costimulatory TNF 
       receptor

<130>  P34209-WO

<150>  EP17163561.8
<151>  2017-03-29

<160>  226   

<170>  PatentIn version 3.5

<210>  1
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala 
            180                 185     


<210>  2
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-H1

<400>  2

Ser Tyr Ala Ile Ser 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC-564, 17A9)  CDR-H1

<400>  3

Ser Tyr Ala Met Ser 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-H2

<400>  4

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC-564, 17A9)  CDR-H2

<400>  5

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  CDR-H3

<400>  6

Glu Tyr Gly Trp Met Asp Tyr 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  CDR-H3

<400>  7

Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr 
1               5                   


<210>  8
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  CDR-H3

<400>  8

Glu Tyr Gly Ser Met Asp Tyr 
1               5           


<210>  9
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  CDR-H3

<400>  9

Val Asn Tyr Pro Tyr Ser Tyr Trp Gly Asp Phe Asp Tyr 
1               5                   10              


<210>  10
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563)  CDR-H3

<400>  10

Asp Val Gly Ala Phe Asp Tyr 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-564)  CDR-H3

<400>  11

Asp Val Gly Pro Phe Asp Tyr 
1               5           


<210>  12
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9)-CDR-H3

<400>  12

Val Phe Tyr Arg Gly Gly Val Ser Met Asp Tyr 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-L1

<400>  13

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  14
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC564)  CDR-L1

<400>  14

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  15
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9) CDR-L1

<400>  15

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-L2

<400>  16

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC564)  CDR-L2

<400>  17

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9) CDR-L2

<400>  18

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  CDR-L3

<400>  19

Gln Gln Tyr Leu Thr Tyr Ser Arg Phe Thr 
1               5                   10  


<210>  20
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  CDR-L3

<400>  20

Gln Gln Tyr Ser Ser Gln Pro Tyr Thr 
1               5                   


<210>  21
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  CDR-L3

<400>  21

Gln Gln Tyr Ile Ser Tyr Ser Met Leu Thr 
1               5                   10  


<210>  22
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  CDR-L3

<400>  22

Gln Gln Tyr Gln Ala Phe Ser Leu Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC-164)  CDR-L3

<400>  23

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  24
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9) CDR-L3

<400>  24

Asn Ser Arg Val Met Pro His Asn Arg Val 
1               5                   10  


<210>  25
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  VH

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Trp Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  26
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  VL

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Thr Tyr Ser Arg 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  27
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  VH

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  28
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  VL

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  29
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  VH

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Ser Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  30
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  VL

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser Tyr Ser Met 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  31
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  VH

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asn Tyr Pro Tyr Ser Tyr Trp Gly Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  32
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  VL

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Ala Phe Ser Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  33
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563)  VH

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Val Gly Ala Phe Asp Tyr Trp Gly Gln Gly Ala Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  34
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563)  VL

<400>  34

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  35
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-564)  VH

<400>  35

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Asp Val Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  36
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-564)  VL

<400>  36

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  37
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9)  VH

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Phe Tyr Arg Gly Gly Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  38
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9)  VL

<400>  38

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Val Met Pro His Asn Arg 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105     


<210>  39
<211>  2201
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Gly Ala Met Thr Gln Leu Leu Ala Gly Val Phe Leu Ala Phe Leu 
1               5                   10                  15      


Ala Leu Ala Thr Glu Gly Gly Val Leu Lys Lys Val Ile Arg His Lys 
            20                  25                  30          


Arg Gln Ser Gly Val Asn Ala Thr Leu Pro Glu Glu Asn Gln Pro Val 
        35                  40                  45              


Val Phe Asn His Val Tyr Asn Ile Lys Leu Pro Val Gly Ser Gln Cys 
    50                  55                  60                  


Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Ala Pro Pro 
65                  70                  75                  80  


Ser Glu Pro Ser Glu Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                85                  90                  95      


Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
            100                 105                 110         


Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
        115                 120                 125             


Leu Glu Asn Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Ala Gly Ala 
    130                 135                 140                 


Gly Cys Cys Leu Gln Pro Ala Thr Gly Arg Leu Asp Thr Arg Pro Phe 
145                 150                 155                 160 


Cys Ser Gly Arg Gly Asn Phe Ser Thr Glu Gly Cys Gly Cys Val Cys 
                165                 170                 175     


Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Glu Cys Pro Gly 
            180                 185                 190         


Asn Cys His Leu Arg Gly Arg Cys Ile Asp Gly Gln Cys Ile Cys Asp 
        195                 200                 205             


Asp Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Ser Asp 
    210                 215                 220                 


Cys Asn Asp Gln Gly Lys Cys Val Asn Gly Val Cys Ile Cys Phe Glu 
225                 230                 235                 240 


Gly Tyr Ala Gly Ala Asp Cys Ser Arg Glu Ile Cys Pro Val Pro Cys 
                245                 250                 255     


Ser Glu Glu His Gly Thr Cys Val Asp Gly Leu Cys Val Cys His Asp 
            260                 265                 270         


Gly Phe Ala Gly Asp Asp Cys Asn Lys Pro Leu Cys Leu Asn Asn Cys 
        275                 280                 285             


Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
    290                 295                 300                 


Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
305                 310                 315                 320 


Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                325                 330                 335     


Thr Gly Glu Asp Cys Gly Lys Pro Thr Cys Pro His Ala Cys His Thr 
            340                 345                 350         


Gln Gly Arg Cys Glu Glu Gly Gln Cys Val Cys Asp Glu Gly Phe Ala 
        355                 360                 365             


Gly Val Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His Asn Arg 
    370                 375                 380                 


Gly Arg Cys Val Asp Gly Arg Cys Glu Cys Asp Asp Gly Phe Thr Gly 
385                 390                 395                 400 


Ala Asp Cys Gly Glu Leu Lys Cys Pro Asn Gly Cys Ser Gly His Gly 
                405                 410                 415     


Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
            420                 425                 430         


Asp Cys Ser Gln Leu Arg Cys Pro Asn Asp Cys His Ser Arg Gly Arg 
        435                 440                 445             


Cys Val Glu Gly Lys Cys Val Cys Glu Gln Gly Phe Lys Gly Tyr Asp 
    450                 455                 460                 


Cys Ser Asp Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
465                 470                 475                 480 


Val Asn Gly Met Cys Val Cys Asp Asp Gly Tyr Thr Gly Glu Asp Cys 
                485                 490                 495     


Arg Asp Arg Gln Cys Pro Arg Asp Cys Ser Asn Arg Gly Leu Cys Val 
            500                 505                 510         


Asp Gly Gln Cys Val Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
        515                 520                 525             


Glu Leu Ser Cys Pro Asn Asp Cys His Gly Gln Gly Arg Cys Val Asn 
    530                 535                 540                 


Gly Gln Cys Val Cys His Glu Gly Phe Met Gly Lys Asp Cys Lys Glu 
545                 550                 555                 560 


Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Val Asp Gly 
                565                 570                 575     


Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln His 
            580                 585                 590         


Ser Cys Pro Ser Asp Cys Asn Asn Leu Gly Gln Cys Val Ser Gly Arg 
        595                 600                 605             


Cys Ile Cys Asn Glu Gly Tyr Ser Gly Glu Asp Cys Ser Glu Val Ser 
    610                 615                 620                 


Pro Pro Lys Asp Leu Val Val Thr Glu Val Thr Glu Glu Thr Val Asn 
625                 630                 635                 640 


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Val Val Tyr 
                645                 650                 655     


Thr Pro Thr His Glu Gly Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
            660                 665                 670         


Asp Gln Thr Ser Thr Ile Ile Gln Glu Leu Glu Pro Gly Val Glu Tyr 
        675                 680                 685             


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Lys Ser Ile Pro Val 
    690                 695                 700                 


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
705                 710                 715                 720 


Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                725                 730                 735     


Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
            740                 745                 750         


Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
        755                 760                 765             


Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
    770                 775                 780                 


Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Arg Val Thr Thr 
785                 790                 795                 800 


Thr Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp 
                805                 810                 815     


Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly 
            820                 825                 830         


Ile Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        835                 840                 845             


Ile Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys 
    850                 855                 860                 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met 
865                 870                 875                 880 


Ser Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu Asp Ala Pro 
                885                 890                 895     


Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
            900                 905                 910         


Trp Arg Asn Gly Lys Ala Ala Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
        915                 920                 925             


Pro Ile Ser Gly Gly Asp His Ala Glu Val Asp Val Pro Lys Ser Gln 
    930                 935                 940                 


Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
945                 950                 955                 960 


Tyr Gly Ile Gly Val Ser Ala Val Lys Glu Asp Lys Glu Ser Asn Pro 
                965                 970                 975     


Ala Thr Ile Asn Ala Ala Thr Glu Leu Asp Thr Pro Lys Asp Leu Gln 
            980                 985                 990         


Val Ser Glu Thr Ala Glu Thr Ser  Leu Thr Leu Leu Trp  Lys Thr Pro 
        995                 1000                 1005             


Leu Ala  Lys Phe Asp Arg Tyr  Arg Leu Asn Tyr Ser  Leu Pro Thr 
    1010                 1015                 1020             


Gly Gln  Trp Val Gly Val Gln  Leu Pro Arg Asn Thr  Thr Ser Tyr 
    1025                 1030                 1035             


Val Leu  Arg Gly Leu Glu Pro  Gly Gln Glu Tyr Asn  Val Leu Leu 
    1040                 1045                 1050             


Thr Ala  Glu Lys Gly Arg His  Lys Ser Lys Pro Ala  Arg Val Lys 
    1055                 1060                 1065             


Ala Ser  Thr Glu Gln Ala Pro  Glu Leu Glu Asn Leu  Thr Val Thr 
    1070                 1075                 1080             


Glu Val  Gly Trp Asp Gly Leu  Arg Leu Asn Trp Thr  Ala Ala Asp 
    1085                 1090                 1095             


Gln Ala  Tyr Glu His Phe Ile  Ile Gln Val Gln Glu  Ala Asn Lys 
    1100                 1105                 1110             


Val Glu  Ala Ala Arg Asn Leu  Thr Val Pro Gly Ser  Leu Arg Ala 
    1115                 1120                 1125             


Val Asp  Ile Pro Gly Leu Lys  Ala Ala Thr Pro Tyr  Thr Val Ser 
    1130                 1135                 1140             


Ile Tyr  Gly Val Ile Gln Gly  Tyr Arg Thr Pro Val  Leu Ser Ala 
    1145                 1150                 1155             


Glu Ala  Ser Thr Gly Glu Thr  Pro Asn Leu Gly Glu  Val Val Val 
    1160                 1165                 1170             


Ala Glu  Val Gly Trp Asp Ala  Leu Lys Leu Asn Trp  Thr Ala Pro 
    1175                 1180                 1185             


Glu Gly  Ala Tyr Glu Tyr Phe  Phe Ile Gln Val Gln  Glu Ala Asp 
    1190                 1195                 1200             


Thr Val  Glu Ala Ala Gln Asn  Leu Thr Val Pro Gly  Gly Leu Arg 
    1205                 1210                 1215             


Ser Thr  Asp Leu Pro Gly Leu  Lys Ala Ala Thr His  Tyr Thr Ile 
    1220                 1225                 1230             


Thr Ile  Arg Gly Val Thr Gln  Asp Phe Ser Thr Thr  Pro Leu Ser 
    1235                 1240                 1245             


Val Glu  Val Leu Thr Glu Glu  Val Pro Asp Met Gly  Asn Leu Thr 
    1250                 1255                 1260             


Val Thr  Glu Val Ser Trp Asp  Ala Leu Arg Leu Asn  Trp Thr Thr 
    1265                 1270                 1275             


Pro Asp  Gly Thr Tyr Asp Gln  Phe Thr Ile Gln Val  Gln Glu Ala 
    1280                 1285                 1290             


Asp Gln  Val Glu Glu Ala His  Asn Leu Thr Val Pro  Gly Ser Leu 
    1295                 1300                 1305             


Arg Ser  Met Glu Ile Pro Gly  Leu Arg Ala Gly Thr  Pro Tyr Thr 
    1310                 1315                 1320             


Val Thr  Leu His Gly Glu Val  Arg Gly His Ser Thr  Arg Pro Leu 
    1325                 1330                 1335             


Ala Val  Glu Val Val Thr Glu  Asp Leu Pro Gln Leu  Gly Asp Leu 
    1340                 1345                 1350             


Ala Val  Ser Glu Val Gly Trp  Asp Gly Leu Arg Leu  Asn Trp Thr 
    1355                 1360                 1365             


Ala Ala  Asp Asn Ala Tyr Glu  His Phe Val Ile Gln  Val Gln Glu 
    1370                 1375                 1380             


Val Asn  Lys Val Glu Ala Ala  Gln Asn Leu Thr Leu  Pro Gly Ser 
    1385                 1390                 1395             


Leu Arg  Ala Val Asp Ile Pro  Gly Leu Glu Ala Ala  Thr Pro Tyr 
    1400                 1405                 1410             


Arg Val  Ser Ile Tyr Gly Val  Ile Arg Gly Tyr Arg  Thr Pro Val 
    1415                 1420                 1425             


Leu Ser  Ala Glu Ala Ser Thr  Ala Lys Glu Pro Glu  Ile Gly Asn 
    1430                 1435                 1440             


Leu Asn  Val Ser Asp Ile Thr  Pro Glu Ser Phe Asn  Leu Ser Trp 
    1445                 1450                 1455             


Met Ala  Thr Asp Gly Ile Phe  Glu Thr Phe Thr Ile  Glu Ile Ile 
    1460                 1465                 1470             


Asp Ser  Asn Arg Leu Leu Glu  Thr Val Glu Tyr Asn  Ile Ser Gly 
    1475                 1480                 1485             


Ala Glu  Arg Thr Ala His Ile  Ser Gly Leu Pro Pro  Ser Thr Asp 
    1490                 1495                 1500             


Phe Ile  Val Tyr Leu Ser Gly  Leu Ala Pro Ser Ile  Arg Thr Lys 
    1505                 1510                 1515             


Thr Ile  Ser Ala Thr Ala Thr  Thr Glu Ala Leu Pro  Leu Leu Glu 
    1520                 1525                 1530             


Asn Leu  Thr Ile Ser Asp Ile  Asn Pro Tyr Gly Phe  Thr Val Ser 
    1535                 1540                 1545             


Trp Met  Ala Ser Glu Asn Ala  Phe Asp Ser Phe Leu  Val Thr Val 
    1550                 1555                 1560             


Val Asp  Ser Gly Lys Leu Leu  Asp Pro Gln Glu Phe  Thr Leu Ser 
    1565                 1570                 1575             


Gly Thr  Gln Arg Lys Leu Glu  Leu Arg Gly Leu Ile  Thr Gly Ile 
    1580                 1585                 1590             


Gly Tyr  Glu Val Met Val Ser  Gly Phe Thr Gln Gly  His Gln Thr 
    1595                 1600                 1605             


Lys Pro  Leu Arg Ala Glu Ile  Val Thr Glu Ala Glu  Pro Glu Val 
    1610                 1615                 1620             


Asp Asn  Leu Leu Val Ser Asp  Ala Thr Pro Asp Gly  Phe Arg Leu 
    1625                 1630                 1635             


Ser Trp  Thr Ala Asp Glu Gly  Val Phe Asp Asn Phe  Val Leu Lys 
    1640                 1645                 1650             


Ile Arg  Asp Thr Lys Lys Gln  Ser Glu Pro Leu Glu  Ile Thr Leu 
    1655                 1660                 1665             


Leu Ala  Pro Glu Arg Thr Arg  Asp Ile Thr Gly Leu  Arg Glu Ala 
    1670                 1675                 1680             


Thr Glu  Tyr Glu Ile Glu Leu  Tyr Gly Ile Ser Lys  Gly Arg Arg 
    1685                 1690                 1695             


Ser Gln  Thr Val Ser Ala Ile  Ala Thr Thr Ala Met  Gly Ser Pro 
    1700                 1705                 1710             


Lys Glu  Val Ile Phe Ser Asp  Ile Thr Glu Asn Ser  Ala Thr Val 
    1715                 1720                 1725             


Ser Trp  Arg Ala Pro Thr Ala  Gln Val Glu Ser Phe  Arg Ile Thr 
    1730                 1735                 1740             


Tyr Val  Pro Ile Thr Gly Gly  Thr Pro Ser Met Val  Thr Val Asp 
    1745                 1750                 1755             


Gly Thr  Lys Thr Gln Thr Arg  Leu Val Lys Leu Ile  Pro Gly Val 
    1760                 1765                 1770             


Glu Tyr  Leu Val Ser Ile Ile  Ala Met Lys Gly Phe  Glu Glu Ser 
    1775                 1780                 1785             


Glu Pro  Val Ser Gly Ser Phe  Thr Thr Ala Leu Asp  Gly Pro Ser 
    1790                 1795                 1800             


Gly Leu  Val Thr Ala Asn Ile  Thr Asp Ser Glu Ala  Leu Ala Arg 
    1805                 1810                 1815             


Trp Gln  Pro Ala Ile Ala Thr  Val Asp Ser Tyr Val  Ile Ser Tyr 
    1820                 1825                 1830             


Thr Gly  Glu Lys Val Pro Glu  Ile Thr Arg Thr Val  Ser Gly Asn 
    1835                 1840                 1845             


Thr Val  Glu Tyr Ala Leu Thr  Asp Leu Glu Pro Ala  Thr Glu Tyr 
    1850                 1855                 1860             


Thr Leu  Arg Ile Phe Ala Glu  Lys Gly Pro Gln Lys  Ser Ser Thr 
    1865                 1870                 1875             


Ile Thr  Ala Lys Phe Thr Thr  Asp Leu Asp Ser Pro  Arg Asp Leu 
    1880                 1885                 1890             


Thr Ala  Thr Glu Val Gln Ser  Glu Thr Ala Leu Leu  Thr Trp Arg 
    1895                 1900                 1905             


Pro Pro  Arg Ala Ser Val Thr  Gly Tyr Leu Leu Val  Tyr Glu Ser 
    1910                 1915                 1920             


Val Asp  Gly Thr Val Lys Glu  Val Ile Val Gly Pro  Asp Thr Thr 
    1925                 1930                 1935             


Ser Tyr  Ser Leu Ala Asp Leu  Ser Pro Ser Thr His  Tyr Thr Ala 
    1940                 1945                 1950             


Lys Ile  Gln Ala Leu Asn Gly  Pro Leu Arg Ser Asn  Met Ile Gln 
    1955                 1960                 1965             


Thr Ile  Phe Thr Thr Ile Gly  Leu Leu Tyr Pro Phe  Pro Lys Asp 
    1970                 1975                 1980             


Cys Ser  Gln Ala Met Leu Asn  Gly Asp Thr Thr Ser  Gly Leu Tyr 
    1985                 1990                 1995             


Thr Ile  Tyr Leu Asn Gly Asp  Lys Ala Glu Ala Leu  Glu Val Phe 
    2000                 2005                 2010             


Cys Asp  Met Thr Ser Asp Gly  Gly Gly Trp Ile Val  Phe Leu Arg 
    2015                 2020                 2025             


Arg Lys  Asn Gly Arg Glu Asn  Phe Tyr Gln Asn Trp  Lys Ala Tyr 
    2030                 2035                 2040             


Ala Ala  Gly Phe Gly Asp Arg  Arg Glu Glu Phe Trp  Leu Gly Leu 
    2045                 2050                 2055             


Asp Asn  Leu Asn Lys Ile Thr  Ala Gln Gly Gln Tyr  Glu Leu Arg 
    2060                 2065                 2070             


Val Asp  Leu Arg Asp His Gly  Glu Thr Ala Phe Ala  Val Tyr Asp 
    2075                 2080                 2085             


Lys Phe  Ser Val Gly Asp Ala  Lys Thr Arg Tyr Lys  Leu Lys Val 
    2090                 2095                 2100             


Glu Gly  Tyr Ser Gly Thr Ala  Gly Asp Ser Met Ala  Tyr His Asn 
    2105                 2110                 2115             


Gly Arg  Ser Phe Ser Thr Phe  Asp Lys Asp Thr Asp  Ser Ala Ile 
    2120                 2125                 2130             


Thr Asn  Cys Ala Leu Ser Tyr  Lys Gly Ala Phe Trp  Tyr Arg Asn 
    2135                 2140                 2145             


Cys His  Arg Val Asn Leu Met  Gly Arg Tyr Gly Asp  Asn Asn His 
    2150                 2155                 2160             


Ser Gln  Gly Val Asn Trp Phe  His Trp Lys Gly His  Glu His Ser 
    2165                 2170                 2175             


Ile Gln  Phe Ala Glu Met Lys  Leu Arg Pro Ser Asn  Phe Arg Asn 
    2180                 2185                 2190             


Leu Glu  Gly Arg Arg Lys Arg  Ala 
    2195                 2200     


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4)  CDR-H1

<400>  40

Ser Tyr Ala Ile Ser 
1               5   


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7)  CDR-H1

<400>  41

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4)  CDR-H2

<400>  42

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7)  CDR-H2

<400>  43

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4)  CDR-H3

<400>  44

Gly Asn Phe Tyr Gly Gly Leu Asp Tyr 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7)  CDR-H3

<400>  45

Thr Ser Pro Arg Val Pro Leu Asp Tyr 
1               5                   


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4)  CDR-L1

<400>  46

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7)  CDR-L1

<400>  47

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4)  CDR-L2

<400>  48

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7)  CDR-L2

<400>  49

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4)  CDR-L3

<400>  50

Gln Gln Asn Lys Lys Phe Pro Ser Gly Thr 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7)  CDR-L3

<400>  51

Asn Ser Ile Asn Ser Thr Arg Asn Glu Val 
1               5                   10  


<210>  52
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4) VH

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  53
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4) VL

<400>  53

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Lys Lys Phe Pro Ser 
                85                  90                  95      


Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  54
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7) VH

<400>  54

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Ser Pro Arg Val Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  55
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7) VL

<400>  55

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ile Asn Ser Thr Arg Asn Glu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  56
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  57
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  58
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  59
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  60
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  61
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  62
<211>  272
<212>  PRT
<213>  Mus musculus

<400>  62

Met Tyr Val Trp Val Gln Gln Pro Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Thr Leu Gly Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr 
            20                  25                  30          


Pro Ser Gly His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met 
        35                  40                  45              


Val Ser Arg Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu 
    50                  55                  60                  


Thr Gly Phe Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys 
65                  70                  75                  80  


Thr Gln Cys Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr 
                85                  90                  95      


Pro Thr Gln Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg 
            100                 105                 110         


Gln Asp Ser Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro 
        115                 120                 125             


Gly His Phe Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn 
    130                 135                 140                 


Cys Thr Leu Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu 
145                 150                 155                 160 


Asp Ala Val Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu 
                165                 170                 175     


Thr Gln Arg Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val 
            180                 185                 190         


Trp Pro Arg Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro 
        195                 200                 205             


Glu Gly Pro Ala Phe Ala Val Leu Leu Gly Leu Gly Leu Gly Leu Leu 
    210                 215                 220                 


Ala Pro Leu Thr Val Leu Leu Ala Leu Tyr Leu Leu Arg Lys Ala Trp 
225                 230                 235                 240 


Arg Leu Pro Asn Thr Pro Lys Pro Cys Trp Gly Asn Ser Phe Arg Thr 
                245                 250                 255     


Pro Ile Gln Glu Glu His Thr Asp Ala His Phe Thr Leu Ala Lys Ile 
            260                 265                 270         


<210>  63
<211>  2110
<212>  PRT
<213>  Mus musculus

<400>  63

Met Gly Ala Val Thr Trp Leu Leu Pro Gly Ile Phe Leu Ala Leu Phe 
1               5                   10                  15      


Ala Leu Thr Pro Glu Gly Gly Val Leu Lys Lys Ile Ile Arg His Lys 
            20                  25                  30          


Arg Glu Ser Gly Leu Asn Met Thr Leu Pro Glu Glu Asn Gln Pro Val 
        35                  40                  45              


Val Phe Asn His Ile Tyr Asn Ile Lys Leu Pro Met Gly Ser Gln Cys 
    50                  55                  60                  


Ser Val Asp Leu Glu Ser Ala Ser Gly Glu Lys Asp Leu Thr Pro Thr 
65                  70                  75                  80  


Pro Glu Ser Ser Gly Ser Phe Gln Glu His Thr Val Asp Gly Glu Asn 
                85                  90                  95      


Gln Ile Val Phe Thr His Arg Ile Asn Ile Pro Arg Arg Ala Cys Gly 
            100                 105                 110         


Cys Ala Ala Ala Pro Asp Val Lys Glu Leu Leu Ser Arg Leu Glu Glu 
        115                 120                 125             


Leu Glu Leu Leu Val Ser Ser Leu Arg Glu Gln Cys Thr Met Gly Thr 
    130                 135                 140                 


Gly Cys Cys Leu Gln Pro Ala Glu Gly Arg Leu Asp Thr Arg Pro Phe 
145                 150                 155                 160 


Cys Ser Gly Arg Gly Asn Phe Ser Ala Glu Gly Cys Gly Cys Val Cys 
                165                 170                 175     


Glu Pro Gly Trp Lys Gly Pro Asn Cys Ser Glu Pro Asp Cys Pro Gly 
            180                 185                 190         


Asn Cys Asn Leu Arg Gly Gln Cys Leu Asp Gly Gln Cys Ile Cys Asp 
        195                 200                 205             


Glu Gly Phe Thr Gly Glu Asp Cys Ser Gln Leu Ala Cys Pro Asn Asp 
    210                 215                 220                 


Cys Asn Asp Gln Gly Arg Cys Val Asn Gly Val Cys Val Cys Phe Glu 
225                 230                 235                 240 


Gly Tyr Ala Gly Pro Asp Cys Gly Leu Glu Val Cys Pro Val Pro Cys 
                245                 250                 255     


Ser Glu Glu His Gly Met Cys Val Asp Gly Arg Cys Val Cys Lys Asp 
            260                 265                 270         


Gly Phe Ala Gly Glu Asp Cys Asn Glu Pro Leu Cys Leu Asn Asn Cys 
        275                 280                 285             


Tyr Asn Arg Gly Arg Cys Val Glu Asn Glu Cys Val Cys Asp Glu Gly 
    290                 295                 300                 


Phe Thr Gly Glu Asp Cys Ser Glu Leu Ile Cys Pro Asn Asp Cys Phe 
305                 310                 315                 320 


Asp Arg Gly Arg Cys Ile Asn Gly Thr Cys Tyr Cys Glu Glu Gly Phe 
                325                 330                 335     


Thr Gly Glu Asp Cys Gly Glu Leu Thr Cys Pro Asn Asp Cys Gln Gly 
            340                 345                 350         


Arg Gly Gln Cys Glu Glu Gly Gln Cys Val Cys Asn Glu Gly Phe Ala 
        355                 360                 365             


Gly Ala Asp Cys Ser Glu Lys Arg Cys Pro Ala Asp Cys His His Arg 
    370                 375                 380                 


Gly Arg Cys Leu Asn Gly Gln Cys Glu Cys Asp Asp Gly Phe Thr Gly 
385                 390                 395                 400 


Ala Asp Cys Gly Asp Leu Gln Cys Pro Asn Gly Cys Ser Gly His Gly 
                405                 410                 415     


Arg Cys Val Asn Gly Gln Cys Val Cys Asp Glu Gly Tyr Thr Gly Glu 
            420                 425                 430         


Asp Cys Ser Gln Arg Arg Cys Pro Asn Asp Cys His Asn Arg Gly Leu 
        435                 440                 445             


Cys Val Gln Gly Lys Cys Ile Cys Glu Gln Gly Phe Lys Gly Phe Asp 
    450                 455                 460                 


Cys Ser Glu Met Ser Cys Pro Asn Asp Cys His Gln His Gly Arg Cys 
465                 470                 475                 480 


Val Asn Gly Met Cys Ile Cys Asp Asp Asp Tyr Thr Gly Glu Asp Cys 
                485                 490                 495     


Arg Asp Arg Arg Cys Pro Arg Asp Cys Ser Gln Arg Gly Arg Cys Val 
            500                 505                 510         


Asp Gly Gln Cys Ile Cys Glu Asp Gly Phe Thr Gly Pro Asp Cys Ala 
        515                 520                 525             


Glu Leu Ser Cys Pro Ser Asp Cys His Gly His Gly Arg Cys Val Asn 
    530                 535                 540                 


Gly Gln Cys Ile Cys His Glu Gly Phe Thr Gly Lys Asp Cys Lys Glu 
545                 550                 555                 560 


Gln Arg Cys Pro Ser Asp Cys His Gly Gln Gly Arg Cys Glu Asp Gly 
                565                 570                 575     


Gln Cys Ile Cys His Glu Gly Phe Thr Gly Leu Asp Cys Gly Gln Arg 
            580                 585                 590         


Ser Cys Pro Asn Asp Cys Ser Asn Gln Gly Gln Cys Val Ser Gly Arg 
        595                 600                 605             


Cys Ile Cys Asn Glu Gly Tyr Thr Gly Ile Asp Cys Ser Glu Val Ser 
    610                 615                 620                 


Pro Pro Lys Asp Leu Ile Val Thr Glu Val Thr Glu Glu Thr Val Asn 
625                 630                 635                 640 


Leu Ala Trp Asp Asn Glu Met Arg Val Thr Glu Tyr Leu Ile Met Tyr 
                645                 650                 655     


Thr Pro Thr His Ala Asp Gly Leu Glu Met Gln Phe Arg Val Pro Gly 
            660                 665                 670         


Asp Gln Thr Ser Thr Thr Ile Arg Glu Leu Glu Pro Gly Val Glu Tyr 
        675                 680                 685             


Phe Ile Arg Val Phe Ala Ile Leu Glu Asn Lys Arg Ser Ile Pro Val 
    690                 695                 700                 


Ser Ala Arg Val Ala Thr Tyr Leu Pro Ala Pro Glu Gly Leu Lys Phe 
705                 710                 715                 720 


Lys Ser Ile Lys Glu Thr Ser Val Glu Val Glu Trp Asp Pro Leu Asp 
                725                 730                 735     


Ile Ala Phe Glu Thr Trp Glu Ile Ile Phe Arg Asn Met Asn Lys Glu 
            740                 745                 750         


Asp Glu Gly Glu Ile Thr Lys Ser Leu Arg Arg Pro Glu Thr Ser Tyr 
        755                 760                 765             


Arg Gln Thr Gly Leu Ala Pro Gly Gln Glu Tyr Glu Ile Ser Leu His 
    770                 775                 780                 


Ile Val Lys Asn Asn Thr Arg Gly Pro Gly Leu Lys Lys Val Thr Thr 
785                 790                 795                 800 


Thr Arg Leu Asp Ala Pro Ser His Ile Glu Val Lys Asp Val Thr Asp 
                805                 810                 815     


Thr Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Ser 
            820                 825                 830         


Ile Glu Leu Ser Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        835                 840                 845             


Ile Asp Leu Thr His Glu Asp Asn Gln Tyr Ser Ile Gly Asn Leu Arg 
    850                 855                 860                 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Val Asp Met 
865                 870                 875                 880 


Ala Ser Asn Pro Ala Lys Glu Thr Phe Ile Thr Gly Leu Asp Ala Pro 
                885                 890                 895     


Arg Asn Leu Arg Arg Val Ser Gln Thr Asp Asn Ser Ile Thr Leu Glu 
            900                 905                 910         


Trp Arg Asn Val Lys Ala Asp Ile Asp Ser Tyr Arg Ile Lys Tyr Ala 
        915                 920                 925             


Pro Ile Ser Gly Gly Asp His Ala Glu Ile Asp Val Pro Lys Ser Gln 
    930                 935                 940                 


Gln Ala Thr Thr Lys Thr Thr Leu Thr Gly Leu Arg Pro Gly Thr Glu 
945                 950                 955                 960 


Tyr Gly Ile Gly Val Ser Ala Val Lys Gly Asp Lys Glu Ser Asp Pro 
                965                 970                 975     


Ala Thr Ile Asn Ala Ala Thr Glu Ile Asp Ala Pro Lys Asp Leu Arg 
            980                 985                 990         


Val Ser Glu Thr Thr Gln Asp Ser  Leu Thr Phe Phe Trp  Thr Thr Pro 
        995                 1000                 1005             


Leu Ala  Lys Phe Asp Arg Tyr  Arg Leu Asn Tyr Ser  Leu Pro Thr 
    1010                 1015                 1020             


Gly Gln  Ser Met Glu Val Gln  Leu Pro Lys Asp Ala  Thr Ser His 
    1025                 1030                 1035             


Val Leu  Thr Asp Leu Glu Pro  Gly Gln Glu Tyr Thr  Val Leu Leu 
    1040                 1045                 1050             


Ile Ala  Glu Lys Gly Arg His  Lys Ser Lys Pro Ala  Arg Val Lys 
    1055                 1060                 1065             


Ala Ser  Thr Glu Glu Val Pro  Ser Leu Glu Asn Leu  Thr Val Thr 
    1070                 1075                 1080             


Glu Ala  Gly Trp Asp Gly Leu  Arg Leu Asn Trp Thr  Ala Asp Asp 
    1085                 1090                 1095             


Leu Ala  Tyr Glu Tyr Phe Val  Ile Gln Val Gln Glu  Ala Asn Asn 
    1100                 1105                 1110             


Val Glu  Thr Ala His Asn Phe  Thr Val Pro Gly Asn  Leu Arg Ala 
    1115                 1120                 1125             


Ala Asp  Ile Pro Gly Leu Lys  Val Ala Thr Ser Tyr  Arg Val Ser 
    1130                 1135                 1140             


Ile Tyr  Gly Val Ala Arg Gly  Tyr Arg Thr Pro Val  Leu Ser Ala 
    1145                 1150                 1155             


Glu Thr  Ser Thr Gly Thr Thr  Pro Asn Leu Gly Glu  Val Thr Val 
    1160                 1165                 1170             


Ala Glu  Val Gly Trp Asp Ala  Leu Thr Leu Asn Trp  Thr Ala Pro 
    1175                 1180                 1185             


Glu Gly  Ala Tyr Lys Asn Phe  Phe Ile Gln Val Leu  Glu Ala Asp 
    1190                 1195                 1200             


Thr Thr  Gln Thr Val Gln Asn  Leu Thr Val Pro Gly  Gly Leu Arg 
    1205                 1210                 1215             


Ser Val  Asp Leu Pro Gly Leu  Lys Ala Ala Thr Arg  Tyr Tyr Ile 
    1220                 1225                 1230             


Thr Leu  Arg Gly Val Thr Gln  Asp Phe Gly Thr Ala  Pro Leu Ser 
    1235                 1240                 1245             


Val Glu  Val Leu Thr Glu Asp  Leu Pro Gln Leu Gly  Gly Leu Ser 
    1250                 1255                 1260             


Val Thr  Glu Val Ser Trp Asp  Gly Leu Thr Leu Asn  Trp Thr Thr 
    1265                 1270                 1275             


Asp Asp  Leu Ala Tyr Lys His  Phe Val Val Gln Val  Gln Glu Ala 
    1280                 1285                 1290             


Asn Asn  Val Glu Ala Ala Gln  Asn Leu Thr Val Pro  Gly Ser Leu 
    1295                 1300                 1305             


Arg Ala  Val Asp Ile Pro Gly  Leu Lys Ala Asp Thr  Pro Tyr Arg 
    1310                 1315                 1320             


Val Ser  Ile Tyr Gly Val Ile  Gln Gly Tyr Arg Thr  Pro Met Leu 
    1325                 1330                 1335             


Ser Thr  Asp Val Ser Thr Ala  Arg Glu Pro Glu Ile  Gly Asn Leu 
    1340                 1345                 1350             


Asn Val  Ser Asp Val Thr Pro  Lys Ser Phe Asn Leu  Ser Trp Thr 
    1355                 1360                 1365             


Ala Thr  Asp Gly Ile Phe Asp  Met Phe Thr Ile Glu  Ile Ile Asp 
    1370                 1375                 1380             


Ser Asn  Arg Leu Leu Gln Thr  Ala Glu His Asn Ile  Ser Gly Ala 
    1385                 1390                 1395             


Glu Arg  Thr Ala His Ile Ser  Gly Leu Pro Pro Ser  Thr Asp Phe 
    1400                 1405                 1410             


Ile Val  Tyr Leu Ser Gly Ile  Ala Pro Ser Ile Arg  Thr Lys Thr 
    1415                 1420                 1425             


Ile Ser  Thr Thr Ala Thr Thr  Glu Ala Leu Pro Leu  Leu Glu Asn 
    1430                 1435                 1440             


Leu Thr  Ile Ser Asp Thr Asn  Pro Tyr Gly Phe Thr  Val Ser Trp 
    1445                 1450                 1455             


Thr Ala  Ser Glu Asn Ala Phe  Asp Ser Phe Leu Val  Thr Val Val 
    1460                 1465                 1470             


Asp Ser  Gly Lys Leu Leu Asp  Pro Gln Glu Phe Thr  Leu Ser Gly 
    1475                 1480                 1485             


Thr Gln  Arg Lys Leu Glu Leu  Arg Gly Leu Ile Thr  Gly Ile Gly 
    1490                 1495                 1500             


Tyr Glu  Val Leu Val Ser Gly  Phe Thr Gln Gly His  Gln Thr Lys 
    1505                 1510                 1515             


Pro Leu  Arg Ala Glu Thr Ile  Thr Glu Ala Glu Pro  Glu Val Asp 
    1520                 1525                 1530             


Asn Leu  Leu Val Ser Asp Ala  Thr Pro Asp Gly Phe  Arg Leu Ser 
    1535                 1540                 1545             


Trp Thr  Ala Asp Glu Gly Ile  Phe Asp Ser Phe Val  Ile Arg Ile 
    1550                 1555                 1560             


Arg Asp  Thr Lys Lys Gln Ser  Glu Pro Gln Glu Ile  Ser Leu Pro 
    1565                 1570                 1575             


Ser Pro  Glu Arg Thr Arg Asp  Ile Thr Gly Leu Arg  Glu Ala Thr 
    1580                 1585                 1590             


Glu Tyr  Glu Ile Glu Leu Tyr  Gly Ile Ser Arg Gly  Arg Arg Ser 
    1595                 1600                 1605             


Gln Pro  Val Ser Ala Ile Ala  Thr Thr Ala Met Gly  Ser Pro Lys 
    1610                 1615                 1620             


Glu Ile  Met Phe Ser Asp Ile  Thr Glu Asn Ala Ala  Thr Val Ser 
    1625                 1630                 1635             


Trp Arg  Ala Pro Thr Ala Gln  Val Glu Ser Phe Arg  Ile Thr Tyr 
    1640                 1645                 1650             


Val Pro  Met Thr Gly Gly Ala  Pro Ser Met Val Thr  Val Asp Gly 
    1655                 1660                 1665             


Thr Asp  Thr Glu Thr Arg Leu  Val Lys Leu Thr Pro  Gly Val Glu 
    1670                 1675                 1680             


Tyr Arg  Val Ser Val Ile Ala  Met Lys Gly Phe Glu  Glu Ser Asp 
    1685                 1690                 1695             


Pro Val  Ser Gly Thr Leu Ile  Thr Ala Leu Asp Gly  Pro Ser Gly 
    1700                 1705                 1710             


Leu Leu  Ile Ala Asn Ile Thr  Asp Ser Glu Ala Leu  Ala Met Trp 
    1715                 1720                 1725             


Gln Pro  Ala Ile Ala Thr Val  Asp Ser Tyr Val Ile  Ser Tyr Thr 
    1730                 1735                 1740             


Gly Glu  Arg Val Pro Glu Val  Thr Arg Thr Val Ser  Gly Asn Thr 
    1745                 1750                 1755             


Val Glu  Tyr Glu Leu His Asp  Leu Glu Pro Ala Thr  Glu Tyr Ile 
    1760                 1765                 1770             


Leu Ser  Ile Phe Ala Glu Lys  Gly Gln Gln Lys Ser  Ser Thr Ile 
    1775                 1780                 1785             


Ala Thr  Lys Phe Thr Thr Asp  Leu Asp Ser Pro Arg  Glu Phe Thr 
    1790                 1795                 1800             


Ala Thr  Glu Val Gln Ser Glu  Thr Ala Leu Leu Thr  Trp Arg Pro 
    1805                 1810                 1815             


Pro Arg  Ala Ser Val Thr Gly  Tyr Leu Leu Val Tyr  Glu Ser Val 
    1820                 1825                 1830             


Asp Gly  Thr Val Lys Glu Val  Ile Val Gly Pro Asp  Thr Thr Ser 
    1835                 1840                 1845             


Tyr Ser  Leu Ala Asp Leu Ser  Pro Ser Thr His Tyr  Ser Ala Arg 
    1850                 1855                 1860             


Ile Gln  Ala Leu Ser Gly Ser  Leu Arg Ser Lys Leu  Ile Gln Thr 
    1865                 1870                 1875             


Ile Phe  Thr Thr Ile Gly Leu  Leu Tyr Pro Phe Pro  Arg Asp Cys 
    1880                 1885                 1890             


Ser Gln  Ala Met Leu Asn Gly  Asp Thr Thr Ser Gly  Leu Tyr Thr 
    1895                 1900                 1905             


Ile Tyr  Ile Asn Gly Asp Lys  Thr Gln Ala Leu Glu  Val Tyr Cys 
    1910                 1915                 1920             


Asp Met  Thr Ser Asp Gly Gly  Gly Trp Ile Val Phe  Leu Arg Arg 
    1925                 1930                 1935             


Lys Asn  Gly Arg Glu Asp Phe  Tyr Arg Asn Trp Lys  Ala Tyr Ala 
    1940                 1945                 1950             


Ala Gly  Phe Gly Asp Arg Arg  Glu Glu Phe Trp Leu  Gly Leu Asp 
    1955                 1960                 1965             


Asn Leu  Ser Lys Ile Thr Ala  Gln Gly Gln Tyr Glu  Leu Arg Val 
    1970                 1975                 1980             


Asp Leu  Gln Asp His Gly Glu  Ser Ala Tyr Ala Val  Tyr Asp Arg 
    1985                 1990                 1995             


Phe Ser  Val Gly Asp Ala Lys  Ser Arg Tyr Lys Leu  Lys Val Glu 
    2000                 2005                 2010             


Gly Tyr  Ser Gly Thr Ala Gly  Asp Ser Met Asn Tyr  His Asn Gly 
    2015                 2020                 2025             


Arg Ser  Phe Ser Thr Tyr Asp  Lys Asp Thr Asp Ser  Ala Ile Thr 
    2030                 2035                 2040             


Asn Cys  Ala Leu Ser Tyr Lys  Gly Ala Phe Trp Tyr  Lys Asn Cys 
    2045                 2050                 2055             


His Arg  Val Asn Leu Met Gly  Arg Tyr Gly Asp Asn  Asn His Ser 
    2060                 2065                 2070             


Gln Gly  Val Asn Trp Phe His  Trp Lys Gly His Glu  Tyr Ser Ile 
    2075                 2080                 2085             


Gln Phe  Ala Glu Met Lys Leu  Arg Pro Ser Asn Phe  Arg Asn Leu 
    2090                 2095                 2100             


Glu Gly  Arg Arg Lys Arg Ala  
    2105                 2110 


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Petpide linker G4S

<400>  64

Gly Gly Gly Gly Ser 
1               5   


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (G4S)2

<400>  65

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (SG4)2

<400>  66

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (G4S)3

<400>  67

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  68
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker G4(SG4)2

<400>  68

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  69
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (G4S)4

<400>  69

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GSPGSSSSGS

<400>  70

Gly Ser Pro Gly Ser Ser Ser Ser Gly Ser 
1               5                   10  


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GSGSGSGS

<400>  71

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GSGSGNGS

<400>  72

Gly Ser Gly Ser Gly Asn Gly Ser 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGSGSGSG

<400>  73

Gly Gly Ser Gly Ser Gly Ser Gly 
1               5               


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGSGSG

<400>  74

Gly Gly Ser Gly Ser Gly 
1               5       


<210>  75
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linkeer GGSG

<400>  75

Gly Gly Ser Gly 
1               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGSGNGSG

<400>  76

Gly Gly Ser Gly Asn Gly Ser Gly 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGNGSGSG

<400>  77

Gly Gly Asn Gly Ser Gly Ser Gly 
1               5               


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGNGSG

<400>  78

Gly Gly Asn Gly Ser Gly 
1               5       


<210>  79
<211>  186
<212>  PRT
<213>  cynomolgus

<400>  79

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys Gln 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Asn Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ala Lys Pro Cys Lys Ala Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Pro Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Pro Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Thr Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Arg Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Arg Gly Pro Ala 
            180                 185     


<210>  80
<211>  192
<212>  PRT
<213>  Mus musculus

<400>  80

Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr Pro Ser Gly 
1               5                   10                  15      


His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met Val Ser Arg 
            20                  25                  30          


Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu Thr Gly Phe 
        35                  40                  45              


Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys Thr Gln Cys 
    50                  55                  60                  


Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr Pro Thr Gln 
65                  70                  75                  80  


Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg Gln Asp Ser 
                85                  90                  95      


Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro Gly His Phe 
            100                 105                 110         


Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu 
        115                 120                 125             


Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu Asp Ala Val 
    130                 135                 140                 


Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu Thr Gln Arg 
145                 150                 155                 160 


Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val Trp Pro Arg 
                165                 170                 175     


Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro Glu Gly Pro 
            180                 185                 190         


<210>  81
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  82
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Fc hole chain

<400>  82
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  83
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence human OX40 antigen Fc knob chain

<400>  83
ctgcactgcg tgggcgacac ctaccccagc aacgaccggt gctgccacga gtgcagaccc       60

ggcaacggca tggtgtcccg gtgcagccgg tcccagaaca ccgtgtgcag accttgcggc      120

cctggcttct acaacgacgt ggtgtccagc aagccctgca agccttgtac ctggtgcaac      180

ctgcggagcg gcagcgagcg gaagcagctg tgtaccgcca cccaggatac cgtgtgccgg      240

tgtagagccg gcacccagcc cctggacagc tacaaacccg gcgtggactg cgccccttgc      300

cctcctggcc acttcagccc tggcgacaac caggcctgca agccttggac caactgcacc      360

ctggccggca agcacaccct gcagcccgcc agcaatagca gcgacgccat ctgcgaggac      420

cgggatcctc ctgccaccca gcctcaggaa acccagggcc ctcccgccag acccatcacc      480

gtgcagccta cagaggcctg gcccagaacc agccaggggc ctagcaccag acccgtggaa      540

gtgcctggcg gcagagccgt cgacgaacag ttatattttc agggcggctc acccaaatct      600

gcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      660

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      720

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      780

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      840

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      900

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      960

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgccggga tgagctgacc     1020

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1080

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1140

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1200

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1260

agcctctccc tgtctccggg taaatccgga ggcctgaacg acatcttcga ggcccagaag     1320

attgaatggc acgag                                                      1335


<210>  84
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence cynomolgus OX40 antigen Fc knob chain

<400>  84
ctccactgtg tcggggacac ctaccccagc aacgaccggt gctgtcagga gtgcaggcca       60

ggcaacggga tggtgagccg ctgcaaccgc tcccagaaca cggtgtgccg tccgtgcggg      120

cccggcttct acaacgacgt ggtcagcgcc aagccctgca aggcctgcac atggtgcaac      180

ctcagaagtg ggagtgagcg gaaacagccg tgcacggcca cacaggacac agtctgccgc      240

tgccgggcgg gcacccagcc cctggacagc tacaagcctg gagttgactg tgccccctgc      300

cctccagggc acttctcccc gggcgacaac caggcctgca agccctggac caactgcacc      360

ttggccggga agcacaccct gcagccagcc agcaatagct cggacgccat ctgtgaggac      420

agggaccccc cacccacaca gccccaggag acccagggcc ccccggccag gcccaccact      480

gtccagccca ctgaagcctg gcccagaacc tcacagagac cctccacccg gcccgtggag      540

gtccccaggg gccctgcggt cgacgaacag ttatattttc agggcggctc acccaaatct      600

gcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      660

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      720

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      780

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      840

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      900

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      960

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgccggga tgagctgacc     1020

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1080

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1140

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1200

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1260

agcctctccc tgtctccggg taaatccgga ggcctgaacg acatcttcga ggcccagaag     1320

attgaatggc acgag                                                      1335


<210>  85
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence murine OX40 antigen Fc knob chain

<400>  85
gtgaccgcca gacggctgaa ctgcgtgaag cacacctacc ccagcggcca caagtgctgc       60

agagagtgcc agcccggcca cggcatggtg tccagatgcg accacacacg ggacaccctg      120

tgccaccctt gcgagacagg cttctacaac gaggccgtga actacgatac ctgcaagcag      180

tgcacccagt gcaaccacag aagcggcagc gagctgaagc agaactgcac ccccacccag      240

gataccgtgt gcagatgcag acccggcacc cagcccagac aggacagcgg ctacaagctg      300

ggcgtggact gcgtgccctg ccctcctggc cacttcagcc ccggcaacaa ccaggcctgc      360

aagccctgga ccaactgcac cctgagcggc aagcagacca gacaccccgc cagcgacagc      420

ctggatgccg tgtgcgagga cagaagcctg ctggccaccc tgctgtggga gacacagcgg      480

cccaccttca gacccaccac cgtgcagagc accaccgtgt ggcccagaac cagcgagctg      540

cccagtcctc ctaccctcgt gacacctgag ggccccgtcg acgaacagtt atattttcag      600

ggcggctcac ccaaatctgc agacaaaact cacacatgcc caccgtgccc agcacctgaa      660

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      720

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      780

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      840

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      900

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      960

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1020

tgccgggatg agctgaccaa gaaccaggtc agcctgtggt gcctggtcaa aggcttctat     1080

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1140

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1200

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1260

aaccactaca cgcagaagag cctctccctg tctccgggta aatccggagg cctgaacgac     1320

atcttcgagg cccagaagat tgaatggcac gag                                  1353


<210>  86
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc hole chain

<400>  86

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  87
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human OX40 antigen Fc knob chain

<400>  87

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Asp Glu Gln Leu Tyr 
            180                 185                 190         


Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro 
        195                 200                 205             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                245                 250                 255     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            260                 265                 270         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        275                 280                 285             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    290                 295                 300                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
305                 310                 315                 320 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                325                 330                 335     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            340                 345                 350         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        355                 360                 365             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    370                 375                 380                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
385                 390                 395                 400 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                405                 410                 415     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu 
            420                 425                 430         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        435                 440                 445 


<210>  88
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus OX40 antigen Fc knob chain

<400>  88

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys Gln 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Asn Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ala Lys Pro Cys Lys Ala Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Pro Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Pro Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Thr Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Arg Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Arg Gly Pro Ala Val Asp Glu Gln Leu Tyr 
            180                 185                 190         


Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro 
        195                 200                 205             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                245                 250                 255     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            260                 265                 270         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        275                 280                 285             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    290                 295                 300                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
305                 310                 315                 320 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                325                 330                 335     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            340                 345                 350         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        355                 360                 365             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    370                 375                 380                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
385                 390                 395                 400 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                405                 410                 415     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu 
            420                 425                 430         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        435                 440                 445 


<210>  89
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine OX40 antigen Fc knob chain

<400>  89

Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr Pro Ser Gly 
1               5                   10                  15      


His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met Val Ser Arg 
            20                  25                  30          


Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu Thr Gly Phe 
        35                  40                  45              


Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys Thr Gln Cys 
    50                  55                  60                  


Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr Pro Thr Gln 
65                  70                  75                  80  


Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg Gln Asp Ser 
                85                  90                  95      


Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro Gly His Phe 
            100                 105                 110         


Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu 
        115                 120                 125             


Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu Asp Ala Val 
    130                 135                 140                 


Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu Thr Gln Arg 
145                 150                 155                 160 


Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val Trp Pro Arg 
                165                 170                 175     


Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro Glu Gly Pro 
            180                 185                 190         


Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp 
        195                 200                 205             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                245                 250                 255     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            260                 265                 270         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    290                 295                 300                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        355                 360                 365             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
        435                 440                 445             


Trp His Glu 
    450     


<210>  90
<211>  1613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of library DP88-4

<400>  90
tgaaatacct attgcctacg gcagccgctg gattgttatt actcgcggcc cagccggcca       60

tggccgacat ccagatgacc cagtctcctt ccaccctgtc tgcatctgta ggagaccgtg      120

tcaccatcac ttgccgtgcc agtcagagta ttagtagctg gttggcctgg tatcagcaga      180

aaccagggaa agcccctaag ctcctgatct atgatgcctc cagtttggaa agtggggtcc      240

catcacgttt cagcggcagt ggatccggga cagaattcac tctcaccatc agcagcttgc      300

agcctgatga ttttgcaact tattactgcc aacagtataa tagttattct acgtttggcc      360

agggcaccaa agtcgagatc aagcgtacgg tggctgcacc atctgtcttc atcttcccgc      420

catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct      480

atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg ggtaactccc      540

aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc agcaccctga      600

cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc acccatcagg      660

gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggagcc gcagaacaaa      720

aactcatctc agaagaggat ctgaatggag ccgcagacta caaggacgac gacgacaagg      780

gtgccgcata ataaggcgcg ccaattctat ttcaaggaga cagtcatatg aaatacctgc      840

tgccgaccgc tgctgctggt ctgctgctcc tcgctgccca gccggcgatg gcccaggtgc      900

aattggtgca gtctggggct gaggtgaaga agcctgggtc ctcggtgaag gtctcctgca      960

aggcctccgg aggcacattc agcagctacg ctataagctg ggtgcgacag gcccctggac     1020

aagggctcga gtggatggga gggatcatcc ctatctttgg tacagcaaac tacgcacaga     1080

agttccaggg cagggtcacc attactgcag acaaatccac gagcacagcc tacatggagc     1140

tgagcagcct gagatctgag gacaccgccg tgtattactg tgcgagacta tccccaggcg     1200

gttactatgt tatggatgcc tggggccaag ggaccaccgt gaccgtctcc tcagctagca     1260

ccaaaggccc atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag     1320

cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg tcgtggaact     1380

caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc tcaggactct     1440

actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag acctacatct     1500

gcaacgtgaa tcacaagccc agcaacacca aagtggacaa gaaagttgag cccaaatctt     1560

gtgacgcggc cgcaagcact agtgcccatc accatcacca tcacgccgcg gca            1613


<210>  91
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of Fab light chain Vk1_5

<400>  91
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attctacgtt tggccagggc      300

accaaagtcg agatcaagcg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtg gagccgcaga acaaaaactc      660

atctcagaag aggatctgaa tggagccgca gactacaagg acgacgacga caagggtgcc      720

gca                                                                    723


<210>  92
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vk1_5

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu 
    210                 215                 220                 


Asp Leu Asn Gly Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala 
225                 230                 235                 240 


Ala 
    


<210>  93
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of Fab heavy chain VH1_69

<400>  93
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactatcc      300

ccaggcggtt actatgttat ggatgcctgg ggccaaggga ccaccgtgac cgtctcctca      360

gctagcacca aaggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaaag tggacaagaa agttgagccc      660

aaatcttgtg acgcggccgc aagcactagt gcccatcacc atcaccatca cgccgcggca      720


<210>  94
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab heavy chain VH1_69

<400>  94

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Ala Ala Ala Ser Thr Ser Ala His His His His His His Ala Ala Ala 
225                 230                 235                 240 


<210>  95
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMB3 Primer

<400>  95
caggaaacag ctatgaccat gattac                                            26


<210>  96
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk1_5_L3r_S Primer

<400>  96
ctcgactttg gtgccctggc caaacgtsba atacgaatta tactgttggc agtaataagt       60

tgcaaaatca t                                                            71


<210>  97
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk1_5_L3r_SY Primer

<400>  97
ctcgactttg gtgccctggc caaacgtmhr sgratacgaa ttatactgtt ggcagtaata       60

agttgcaaaa tcat                                                         74


<210>  98
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk1_5_L3r_SPY

<400>  98
ctcgactttg gtgccctggc caaacgtmhh msssgratac gaattatact gttggcagta       60

ataagttgca aaatcat                                                      77


<210>  99
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH31 Primer

<400>  99
acgtttggcc agggcaccaa agtcgag                                           27


<210>  100
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH32 Primer

<400>  100
tctcgcacag taatacacgg cggtgtcc                                          28


<210>  101
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP88-v4-4

<400>  101
ggacaccgcc gtgtattact gtgcgagaga ctactggggc caagggacca ccgtgaccgt       60

ctcc                                                                    64


<210>  102
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP88-v4-6

<400>  102
ggacaccgcc gtgtattact gtgcgagaga ctactggggc caagggacca ccgtgaccgt       60

ctcc                                                                    64


<210>  103
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP88-v4-8

<400>  103
ggacaccgcc gtgtattact gtgcgagaga ctactggggc caagggacca ccgtgaccgt       60

ctcc                                                                    64


<210>  104
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fdseqlong Primer

<400>  104
gacgttagta aatgaatttt ctgtatgagg                                        30


<210>  105
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (Vk3_20/VH3_23) template

<400>  105
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggccgaaa tcgtgttaac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga      120

gccaccctct cttgcagggc cagtcagagt gttagcagca gctacttagc ctggtaccag      180

cagaaacctg gccaggctcc caggctcctc atctatggag catccagcag ggccactggc      240

atcccagaca ggttcagtgg cagtggatcc gggacagact tcactctcac catcagcaga      300

ctggagcctg aagattttgc agtgtattac tgtcagcagt atggtagctc accgctgacg      360

ttcggccagg ggaccaaagt ggaaatcaaa cgtacggtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg tggagccgca      720

catcaccatc accatcacgg agccgcagac tacaaggacg acgacgacaa gggtgccgca      780

taataaggcg cgccaattct atttcaagga gacagtcata tgaaatacct gctgccgacc      840

gctgctgctg gtctgctgct cctcgctgcc cagccggcga tggccgaggt gcaattgctg      900

gagtctgggg gaggcttggt acagcctggg gggtccctga gactctcctg tgcagcctcc      960

ggattcacct ttagcagtta tgccatgagc tgggtccgcc aggctccagg gaaggggctg     1020

gagtgggtct cagctattag tggtagtggt ggtagcacat actacgcaga ctccgtgaag     1080

ggccggttca ccatctccag agacaattcc aagaacacgc tgtatctgca gatgaacagc     1140

ctgagagccg aggacacggc cgtatattac tgtgcgaaac cgtttccgta ttttgactac     1200

tggggccaag gaaccctggt caccgtctcg agtgctagca ccaaaggccc atcggtcttc     1260

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc     1320

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc     1380

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg     1440

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc     1500

agcaacacca aagtggacaa gaaagttgag cccaaatctt gtgacgcggc cgcagaacaa     1560

aaactcatct cagaagagga tctgaatgcc gcggca                               1596


<210>  106
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vk3_20

<400>  106
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct gacgttcggc      300

caggggacca aagtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagc cgcacatcac      660

catcaccatc acggagccgc agactacaag gacgacgacg acaagggtgc cgca            714


<210>  107
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vk3_20

<400>  107

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Gly Ala Ala His His His His His His 
    210                 215                 220                 


Gly Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala 
225                 230                 235             


<210>  108
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab heavy chain VH3_23

<400>  108
gaggtgcaat tgctggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaccgttt      300

ccgtattttg actactgggg ccaaggaacc ctggtcaccg tctcgagtgc tagcaccaaa      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaagtg gacaagaaag ttgagcccaa atcttgtgac      660

gcggccgcag aacaaaaact catctcagaa gaggatctga atgccgcggc a               711


<210>  109
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab heavy chain VH3_23 (DP47)

<400>  109

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ala Ala Ala Glu 
    210                 215                 220                 


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ala Ala Ala 
225                 230                 235         


<210>  110
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS64 Primer

<400>  110
acgttcggcc aggggaccaa agtgg                                             25


<210>  111
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47CDR3_ba Primer

<400>  111
cgcacagtaa tatacggccg tgtcc                                             25


<210>  112
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47-v4-4

<400>  112
cgaggacacg gccgtatatt actgtgcgga ctactggggc caaggaaccc tggtcaccgt       60

ctcg                                                                    64


<210>  113
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47-v4-6

<400>  113
cgaggacacg gccgtatatt actgtgcgga ctactggggc caaggaaccc tggtcaccgt       60

ctcg                                                                    64


<210>  114
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47-v4-8

<400>  114
cgaggacacg gccgtatatt actgtgcgga ctactggggc caaggaaccc tggtcaccgt       60

ctcg                                                                    64


<210>  115
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fdseqlong

<400>  115
gacgttagta aatgaatttt ctgtatgagg                                        30


<210>  116
<211>  1605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl3_19/VH3_23 library template

<400>  116
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggcctcgt ctgagctgac tcaggaccct gctgtgtctg tggccttggg acagacagtc      120

aggatcacat gccaaggaga cagcctcaga agttattatg caagctggta ccagcagaag      180

ccaggacagg cccctgtact tgtcatctat ggtaaaaaca accggccctc agggatccca      240

gaccgattct ctggctccag ctcaggaaac acagcttcct tgaccatcac tggggctcag      300

gcggaagatg aggctgacta ttactgtaac tcccgtgata gtagcggtaa tcatgtggta      360

ttcggcggag ggaccaagct gaccgtccta ggacaaccca aggctgcccc cagcgtgacc      420

ctgttccccc ccagcagcga ggaattgcag gccaacaagg ccaccctggt ctgcctgatc      480

agcgacttct acccaggcgc cgtgaccgtg gcctggaagg ccgacagcag ccccgtgaag      540

gccggcgtgg agaccaccac ccccagcaag cagagcaaca acaagtacgc cgccagcagc      600

tacctgagcc tgacccccga gcagtggaag agccacaggt cctacagctg ccaggtgacc      660

cacgagggca gcaccgtgga gaaaaccgtg gcccccaccg agtgcagcgg agccgcagaa      720

caaaaactca tctcagaaga ggatctgaat ggagccgcag actacaagga cgacgacgac      780

aagggtgccg cataataagg cgcgccaatt ctatttcaag gagacagtca tatgaaatac      840

ctgctgccga ccgctgctgc tggtctgctg ctcctcgctg cccagccggc gatggccgag      900

gtgcaattgc tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      960

tgtgcagcct ccggattcac ctttagcagt tatgccatga gctgggtccg ccaggctcca     1020

gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca     1080

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg     1140

cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa accgtttccg     1200

tattttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaaaggc     1260

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg     1320

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc     1380

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc     1440

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg     1500

aatcacaagc ccagcaacac caaagtggac aagaaagttg agcccaaatc ttgtgacgcg     1560

gccgcaagca ctagtgccca tcaccatcac catcacgccg cggca                     1605


<210>  117
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vl3_19

<400>  117
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gatagtagcg gtaatcatgt ggtattcggc      300

ggagggacca agctgaccgt cctaggacaa cccaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggaatt gcaggccaac aaggccaccc tggtctgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggagaaaac cgtggccccc accgagtgca gcggagccgc agaacaaaaa      660

ctcatctcag aagaggatct gaatggagcc gcagactaca aggacgacga cgacaagggt      720

gccgca                                                                 726


<210>  118
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vl3_19

<400>  118

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu 
    210                 215                 220                 


Glu Asp Leu Asn Gly Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
225                 230                 235                 240 


Ala Ala 
        


<210>  119
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMB3 lambda-DP47 library

<400>  119
caggaaacag ctatgaccat gattac                                            26


<210>  120
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl_3_19_L3r_V lambda-DP47 library

<400>  120
ggacggtcag cttggtccct ccgccgaata cvhvattacc gctactatca cgggagttac       60

agtaatagtc agcctcatct tccgc                                             85


<210>  121
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl_3_19_L3r_HV lambda-DP47

<400>  121
ggacggtcag cttggtccct ccgccgaata ccmmatgatt accgctacta tcacgggagt       60

tacagtaata gtcagcctca tcttccgc                                          88


<210>  122
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl_3_19_L3r_HLV lambda-DP47

<400>  122
ggacggtcag cttggtccct ccgccgaata crhmvwgatg attaccgcta ctatcacggg       60

agttacagta atagtcagcc tcatcttccg c                                      91


<210>  123
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH80 lambda-DP47

<400>  123
ttcggcggag ggaccaagct gaccgtcc                                          28


<210>  124
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS63

<400>  124
tttcgcacag taatatacgg ccgtgtcc                                          28


<210>  125
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (8H9 ) VL

<400>  125
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gttatgcctc ataatcgcgt attcggcgga      300

gggaccaagc tgaccgtc                                                    318


<210>  126
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (8H9) VH

<400>  126
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgttttc      300

taccgtggtg gtgtttctat ggactactgg ggccaaggaa ccctggtcac cgtctcgagt      360


<210>  127
<211>  321
<212>  DNA
<213>  Artificial  Sequence

<220>
<223>  DNA (49B4) VL

<400>  127
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatagttcgc agccgtatac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  128
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (49B4) VH

<400>  128
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctca            354


<210>  129
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (1G4) VL

<400>  129
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatatttcgt attccatgtt gacgtttggc      300

cagggcacca aagtcgagat caag                                             324


<210>  130
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (1G4) VH

<400>  130
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

ggttctatgg actactgggg ccaagggacc accgtgaccg tctcctca                   348


<210>  131
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (20B7) VL

<400>  131
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatcaggctt tttcgcttac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  132
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (20B7) VH

<400>  132
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagttaac      300

tacccgtact cttactgggg tgacttcgac tactggggcc aagggaccac cgtgaccgtc      360

tcctca                                                                 366


<210>  133
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-563) VL

<400>  133
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caag                                             324


<210>  134
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-563) VH

<400>  134
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcttgacgtt      300

ggtgctttcg actactgggg ccaaggagcc ctggtcaccg tctcgagt                   348


<210>  135
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-564) VL

<400>  135
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caag                                             324


<210>  136
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-564) VH

<400>  136
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gttcgacgtt      300

ggtccgttcg actactgggg ccaaggaacc ctggtcaccg tctcgagt                   348


<210>  137
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (17A9) VL

<400>  137
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gttatgcctc ataatcgcgt attcggcgga      300

gggaccaagc tgaccgtc                                                    318


<210>  138
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (17A9) VH

<400>  138
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgttttc      300

taccgtggtg gtgtttctat ggactactgg ggccaaggaa ccctggtcac cgtctcgagt      360


<210>  139
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 8H9 P329GLALA IgG1 light chain

<400>  139
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatttgacgt attcgcggtt tacgtttggc      300

cagggcacca aagtcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  140
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 8H9 P329GLALA IgG1 heavy chain

<400>  140
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

ggttggatgg actactgggg ccaagggacc accgtgaccg tctcctcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  141
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H9 P329GLALA IgG1 light chain

<400>  141

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Thr Tyr Ser Arg 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  142
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H9 P329GLALA IgG1 Heavy chain

<400>  142

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Trp Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  143
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 49B4 P329GLALA IgG1 light chain

<400>  143
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatagttcgc agccgtatac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  144
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 49B4 P329GLALA IgG1 heavy chain

<400>  144
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  145
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49B4 P329GLALA IgG1 light chain

<400>  145

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  146
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49B4 heavy chain

<400>  146

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  147
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 1G4 P329GLALA IgG1 light chain

<400>  147
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatatttcgt attccatgtt gacgtttggc      300

cagggcacca aagtcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  148
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 1G4 P329GLALA IgG1 heavy chain

<400>  148
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

ggttctatgg actactgggg ccaagggacc accgtgaccg tctcctcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  149
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G4 P329GLALA IgG1 light chain

<400>  149

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser Tyr Ser Met 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  150
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G4 P329GLALA IgG1 heavy chain

<400>  150

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Ser Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  151
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA 20B7 P329GLALA IgG1 light chain

<400>  151
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatcaggctt tttcgcttac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  152
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 20B7 P329GLALA IgG1 heavy chain

<400>  152
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagttaac      300

tacccgtact cttactgggg tgacttcgac tactggggcc aagggaccac cgtgaccgtc      360

tcctcagcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagctgca      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcg gcgcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1356


<210>  153
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  20B7 P329GLALA IgG1 Light chain

<400>  153

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Ala Phe Ser Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  154
<211>  452
<212>  PRT
<213>  Artificial

<220>
<223>  20B7 P329GLALA IgG1 heavy chain

<400>  154

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asn Tyr Pro Tyr Ser Tyr Trp Gly Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  155
<211>  645
<212>  DNA
<213>  Artificial

<220>
<223>  DNA CLC-563 P329GLALA IgG1 light chain

<400>  155
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  156
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  DNA CLC-563 P329GLALA IgG1 heavy chain

<400>  156
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcttgacgtt      300

ggtgctttcg actactgggg ccaaggagcc ctggtcaccg tctcgagtgc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  157
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  CLC-563 P329GLALA IgG1 light chain

<400>  157

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  158
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  CLC-563 P329GLALA IgG1 heavy chain

<400>  158

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Val Gly Ala Phe Asp Tyr Trp Gly Gln Gly Ala Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  159
<211>  645
<212>  DNA
<213>  Artificial

<220>
<223>  DNA CLC-564 P329GLALA IgG1 light chain

<400>  159
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  160
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  DNA CLC-564 P329GLALA IgG1 heavy chain

<400>  160
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gttcgacgtt      300

ggtccgttcg actactgggg ccaaggaacc ctggtcaccg tctcgagtgc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  161
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  CLC-564 P329GLALA IgG1 light chain

<400>  161

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  162
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  CLC-564 P329GLALA IgG1 heavy chain

<400>  162

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Asp Val Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  163
<211>  639
<212>  DNA
<213>  Artificial

<220>
<223>  DNA 17A9 P329GLALA IgG1 light chain

<400>  163
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gttatgcctc ataatcgcgt attcggcgga      300

gggaccaagc tgaccgtcct aggtcaaccc aaggctgccc ccagcgtgac cctgttcccc      360

cccagcagcg aggaactgca ggccaacaag gccaccctgg tctgcctgat cagcgacttc      420

tacccaggcg ccgtgaccgt ggcctggaag gccgacagca gccccgtgaa ggccggcgtg      480

gagaccacca cccccagcaa gcagagcaac aacaagtacg ccgccagcag ctacctgagc      540

ctgacccccg agcagtggaa gagccacagg tcctacagct gccaggtgac ccacgagggc      600

agcaccgtgg agaaaaccgt ggcccccacc gagtgcagc                             639


<210>  164
<211>  1350
<212>  DNA
<213>  Artificial

<220>
<223>  DNA 17A9 P329GLALA IgG1 heavy chain

<400>  164
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgttttc      300

taccgtggtg gtgtttctat ggactactgg ggccaaggaa ccctggtcac cgtctcgagt      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc tgcaggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  165
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  17A9 P329GLALA IgG1 light chain

<400>  165

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Val Met Pro His Asn Arg 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  166
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  17A9 P329GLALA IgG1 heavy chain

<400>  166

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Phe Tyr Arg Gly Gly Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  167
<211>  3102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence human TnC with C-terminal Avi- and His-tags

<400>  167
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ggttcaacta gtggttctgg tcatcaccat caccatcact ccgcgggtct ggtgccacgc      720

ggtagtactg caattggtat gaaagaaacc gctgctgcta aattcgaacg ccagcacatg      780

gacagcccag atctgggtac cggtggtggc tccggtattg agggacgcgg gtccatggga      840

tatcggggat ccgagctgga cacccccaag gacctgcagg tgtccgagac agccgagaca      900

agcctgaccc tgctgtggaa aacccccctg gccaagttcg accggtacag actgaactac      960

agcctgccca ctggacagtg ggtcggcgtg cagctgcccc ggaacaccac ctcctacgtg     1020

ctgcggggcc tggaacccgg ccaggaatac aacgtcctgc tgacggccga gaagggccgg     1080

cacaagagca agcccgccag agtgaaggcc agcaccgagc aggcccccga gctggaaaac     1140

ctgaccgtga ccgaagtggg ctgggacggc ctgcggctga actggaccgc ggctgaccag     1200

gcctatgagc actttatcat tcaggtgcag gaggccaaca aggtggaggc agctcggaac     1260

ctcaccgtgc ctggcagcct tcgggctgtg gacataccgg gcctcaaggc tgctacgcct     1320

tatacagtct ccatctatgg ggtgatccag ggctatagaa caccagtgct ctctgctgag     1380

gcctccacag gcgaaacacc gaacctgggc gaagtggtgg tggcggaagt gggttgggat     1440

gcgctgaaac tgaactggac cgcgccggaa ggcgcgtatg aatatttttt catccaggtg     1500

caggaagcgg ataccgttga agcggcgcag aacctgaccg ttccgggcgg tctgcgtagc     1560

accgatctgc cgggcctgaa agcggcgacc cattatacca ttaccatccg tggggtgacc     1620

caggacttct ctaccacccc tctgagcgtg gaggtgctga ccgaggaggt acccgacatg     1680

ggcaacctga ccgtgaccga ggtgtcctgg gacgccctgc ggctgaactg gaccaccccc     1740

gacggcacct acgaccagtt cacaatccag gtgcaggaag ccgaccaggt ggaagaagca     1800

cataatctga ccgttccggg tagcctgcgt agcatggaaa ttccgggtct gcgtgcaggc     1860

accccgtata ccgttaccct gcatggtgaa gttcgtggtc atagcacccg tccgctggca     1920

gttgaagttg ttaccgaaga tctgccgcag ctgggtgatc tggcagttag cgaagttggt     1980

tgggatggtc tgcgtctgaa ttggaccgca gcagataatg catatgaaca ttttgtgatc     2040

caggtgcaag aggtgaataa agttgaagca gcccagaatc tgaccctgcc tggttcactg     2100

cgtgcagttg atattccggg actcgaggca gcaaccccgt atcgtgttag catttatggt     2160

gttattcgcg gttatcgtac accggttctg agcgcagaag caagcaccgc aaaagaaccg     2220

gaaattggta atctgaacgt gagcgatatt acaccggaat catttaatct gagctggatg     2280

gcaaccgatg gtatttttga aacctttacc atcgagatca tcgatagcaa tcgtctgctg     2340

gaaaccgtgg aatataatat tagcggtgca gaacgtaccg cacatattag cggtctgcct     2400

ccgagcaccg attttattgt ttatctgagc ggtctggcac cgagcattcg taccaaaacc     2460

attagcgcaa ccgcaaccac cgaagcactg ccgctgctgg aaaatctgac cattagcgat     2520

attaacccgt atggttttac cgtttcatgg atggcaagcg aaaatgcatt tgatagcttt     2580

ctggttacag ttgtggatag cggtaaactg ctggacccgc aagaatttac cctgagcggc     2640

acccagcgca aactggaact gcgtggtctg attaccggta ttggttatga agttatggtg     2700

agcggtttta cccagggtca tcagaccaaa ccgctgcgtg cagaaattgt taccgaagca     2760

atgggtagcc cgaaagaagt tattttttcc gatatcaccg agaattcggc aaccgttagc     2820

tggcgtgcac cgaccgcaca ggttgaaagc tttcgtatta cctatgttcc gattaccggt     2880

ggcaccccga gcatggttac agttgatggc accaaaaccc agacccgtct ggttaaactg     2940

attccgggtg ttgaatatct ggttagcatt attgccatga aaggctttga agaaagcgaa     3000

ccggttagcg gtagctttac cacagctagc ggcctgaacg acatcttcga ggctcagaaa     3060

atcgaatggc acgaaggtac ccatcaccat caccaccact aa                        3102


<210>  168
<211>  2566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence mouse TnC with C-terminal Avi- and His-tags

<400>  168
tatgtcccct atactaggtt attggaaaat taagggcctt gtgcaaccca ctcgacttct       60

tttggaatat cttgaagaaa aatatgaaga gcatttgtat gagcgcgatg aaggtgataa      120

atggcgaaac aaaaagtttg aattgggttt ggagtttccc aatcttcctt attatattga      180

tggtgatgtt aaattaacac agtctatggc catcatacgt tatatagctg acaagcacaa      240

catgttgggt ggttgtccaa aagagcgtgc agagatttca atgcttgaag gagcggtttt      300

ggatattaga tacggtgttt cgagaattgc atatagtaaa gactttgaaa ctctcaaagt      360

tgattttctt agcaagctac ctgaaatgct gaaaatgttc gaagatcgtt tatgtcataa      420

aacatattta aatggtgatc atgtaaccca tcctgacttc atgttgtatg acgctcttga      480

tgttgtttta tacatggacc caatgtgcct ggatgcgttc ccaaaattag tttgttttaa      540

aaaacgtatt gaagctatcc cacaaattga taagtacttg aaatccagca agtatatagc      600

atggcctttg cagggctggc aagccacgtt tggtggtggc gaccatcctc caaaatcgga      660

tggttcaact agtggttctg gtcatcacca tcaccatcac tccgcgggtc tggtgccacg      720

cggtagtact gcaattggta tgaaagaaac cgctgctgct aaattcgaac gccagcacat      780

ggacagccca gatctgggta ccggtggtgg ctccggtatt gagggacgcg ggtccatggg      840

atatcgggga tccgagctgg acacccccaa ggacctgcag gtgtccgaga cagccgagac      900

aagcctgacc ctgctgtgga aaacccccct ggccaagttc gaccggtaca gactgaacta      960

cagcctgccc actggacagt gggtcggcgt gcagctgccc cggaacacca cctcctacgt     1020

gctgcggggc ctggaacccg gccaggaata caacgtcctg ctgacggccg agaagggccg     1080

gcacaagagc aagcccgcca gagtgaaggc cagcaccgag gaagtgccca gcctggaaaa     1140

cctgaccgtg accgaggccg gctgggacgg cctgcggctg aactggaccg ccgacgacct     1200

ggcctacgag tacttcgtga tccaggtgca ggaagccaac aacgtcgaga cagcccacaa     1260

cttcaccgtg cccggcaacc tgagagccgc cgacatcccc ggcctgaagg tggccacatc     1320

ctaccgggtg tccatctacg gcgtggccag gggctaccgg acccccgtgc tgtccgccga     1380

gacaagcacc ggcaccacgc cgaacctggg cgaagtgacc gtggcggaag tgggttggga     1440

tgcgctgacc ctgaattgga ccgcaccgga aggcgcgtat aaaaactttt tcatccaggt     1500

gctggaagcg gataccaccc agaccgtgca gaacctgacc gtgccgggtg gtctgcgtag     1560

cgtagatctg cctggtctga aagcagcaac ccgctattac attaccctgc gtggtgttac     1620

ccaggatttt ggcaccgcac cgctgagcgt tgaagttctg accgaggatc tgccgcagct     1680

gggtggtctg agcgttaccg aagttagttg ggatggtctg accctgaatt ggaccaccga     1740

tgatctggca tataaacatt ttgtggtgca ggttcaagag gccaataatg ttgaagcagc     1800

acagaatctg accgttccgg gtagcctgcg tgcagttgat attccgggac tgaaagccga     1860

taccccgtat cgtgttagca tttatggtgt tattcagggt tatcgtaccc cgatgctgag     1920

caccgatgtt agcacagcac gtgaaccgga aattggtaat ctgaatgtta gtgatgtgac     1980

cccgaaatca tttaatctga gctggaccgc aaccgatggt atttttgata tgtttaccat     2040

tgaaattatt gatagcaatc gcctgctgca gaccgcagaa cataacatta gcggtgcaga     2100

acgtaccgca catattagcg gtctgcctcc gagcaccgat tttattgttt atctgagcgg     2160

tattgcaccg agcattcgta ccaaaaccat tagcaccacc gcaaccaccg aagcactgac     2220

cgcaatgggt agcccgaaag aagtgatttt tagcgatatt accgaaaata gcgccaccgt     2280

ttcatggcgt gcaccgaccg cacaggttga aagctttcgt attacctatg ttccgattac     2340

cggtggcacc ccgagcatgg ttaccgttga tggcaccaaa acccagaccc gtctggttaa     2400

actgattccg ggtgttgaat atctggttag cattattgcc atgaaaggct ttgaagaaag     2460

cgaaccggtt agcggtagct ttaccacagc tagcggcctg aacgacatct tcgaggctca     2520

gaaaatcgaa tggcacgaag gtacccatca ccatcaccac cactaa                    2566


<210>  169
<211>  2565
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence cynomolgus TnC with C-terminal Avi- and 
       His-tags

<400>  169
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ggttcaacta gtggttctgg tcatcaccat caccatcact ccgcgggtct ggtgccacgc      720

ggtagtactg caattggtat gaaagaaacc gctgctgcta aattcgaacg ccagcacatg      780

gacagcccag atctgggtac cggtggtggc tccggtattg agggacgcgg gtccatggga      840

tatcggggat ccgaactgga taccccgaaa gatctgcgtg ttagcgaaac cgcagaaacc      900

agcctgaccc tgttttggaa aacaccgctg gcaaaatttg atcgttatcg tctgaattat      960

agcctgccga ccggtcagtg ggttggtgtt cagctgcctc gtaataccac cagttatgtt     1020

ctgcgtggtc tggaaccggg tcaagaatat aacgttctgc tgaccgcaga aaaaggtcgt     1080

cataaaagca aaccggcacg tgttaaagca agcaccgaac aggcaccgga actggaaaat     1140

ctgaccgtta ccgaagttgg ctgggatggc ctgcgcctga actggacggc tgcggaccag     1200

gcctacgaac acttcgttat ccaggtgcaa gaagccaaca aagtagaagc cgctcagaat     1260

ctgacggttc cgggaaatct gcgtgcagtt gatattccgg gtctgaaagc agcaaccccg     1320

tataccgtta gcatttatgg tgttattcag ggttatcgta caccggttct gagtgccgaa     1380

gccagcaccg gtgaaacccc gaatctgggt gaagttatgg ttagcgaagt gggctgggat     1440

gcactgaaac tgaattggac agttccggaa ggtgcctatg aatacttttt cattcaggtt     1500

caagaagcgg ataccgttga agccgctcag aatcataccg ttccgggtgg tctgcgtagc     1560

accgatctgc ctggcctgaa agccgctacc cattacacca ttaccattcg tggtgttacc     1620

caggatttta gcaccacacc gctgagcgtt gaagttctga cagaagaact gccgcagctg     1680

ggtgatctgg cagttagcga agttggttgg gatggtctgc gtctgaattg gaccgcagca     1740

gatcaggcat atgaacattt tgttatccag gtgcaagaag tgaacaaagt tgaagcagca     1800

cagaatctga ccgttccggg tagcctgcgt gcagttgata ttccgggtct gaaagcagca     1860

accccgtata ccgttagcat ttatggtgtt attcgcggtt atcgtacacc ggttctgagc     1920

gcagaagcaa gcaccgcaaa agaaccggaa attggtaatc tgaacgtgag cgatattaca     1980

ccggaaagtt ttagcctgag ctggaccgca accgatggta tttttgaaac ctttaccatc     2040

gagatcatcg atagcaatcg tctgctggaa atcgtggaat ataacattag cggtgcagaa     2100

cgtaccgcac atattagcgg tctgcctccg agcaccgatt ttattgttta tctgagcggt     2160

ctggcaccga gctttcgtac caaaaccatt agcgcaaccg caaccaccga agcactgacc     2220

gcaatgggta gcccgaaaga agtgattttt agcgatatta ccgaaaatag cgccaccgtt     2280

tcatggcgtg caccgaccgc acaggttgaa agctttcgta ttacctatgt tccgattacc     2340

ggtggcaccc cgagcatggt taccgtggat ggcaccaaaa cccagacccg tctggttaaa     2400

ctggttccgg gtgttgaata tctggtgaat atcattgcca tgaaaggctt tgaagaaagc     2460

gaaccggtta gcggtagctt taccaccgct agcggcctga acgacatctt cgaggctcag     2520

aaaatcgaat ggcacgaagg tacccatcac catcaccacc actaa                     2565


<210>  170
<211>  1033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human TnC with C-terminal Avi- and His-tags

<400>  170

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln 
385                 390                 395                 400 


Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu Ala Asn Lys Val Glu 
                405                 410                 415     


Ala Ala Arg Asn Leu Thr Val Pro Gly Ser Leu Arg Ala Val Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly 
    450                 455                 460                 


Glu Thr Pro Asn Leu Gly Glu Val Val Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Lys Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Glu Tyr Phe 
                485                 490                 495     


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
    530                 535                 540                 


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu Glu Val Pro Asp Met 
545                 550                 555                 560 


Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln 
            580                 585                 590         


Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 
    610                 615                 620                 


Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu Ala 
625                 630                 635                 640 


Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu Gly Asp Leu Ala Val 
                645                 650                 655     


Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp 
            660                 665                 670         


Asn Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu Val Asn Lys Val 
        675                 680                 685             


Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser Leu Arg Ala Val Asp 
    690                 695                 700                 


Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr Arg Val Ser Ile Tyr Gly 
705                 710                 715                 720 


Val Ile Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr 
                725                 730                 735     


Ala Lys Glu Pro Glu Ile Gly Asn Leu Asn Val Ser Asp Ile Thr Pro 
            740                 745                 750         


Glu Ser Phe Asn Leu Ser Trp Met Ala Thr Asp Gly Ile Phe Glu Thr 
        755                 760                 765             


Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu Leu Glu Thr Val Glu 
    770                 775                 780                 


Tyr Asn Ile Ser Gly Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro 
785                 790                 795                 800 


Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly Leu Ala Pro Ser Ile 
                805                 810                 815     


Arg Thr Lys Thr Ile Ser Ala Thr Ala Thr Thr Glu Ala Leu Pro Leu 
            820                 825                 830         


Leu Glu Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val 
        835                 840                 845             


Ser Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val 
    850                 855                 860                 


Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe Thr Leu Ser Gly 
865                 870                 875                 880 


Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr Gly Ile Gly Tyr 
                885                 890                 895     


Glu Val Met Val Ser Gly Phe Thr Gln Gly His Gln Thr Lys Pro Leu 
            900                 905                 910         


Arg Ala Glu Ile Val Thr Glu Ala Met Gly Ser Pro Lys Glu Val Ile 
        915                 920                 925             


Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala Pro 
    930                 935                 940                 


Thr Ala Gln Val Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr Gly 
945                 950                 955                 960 


Gly Thr Pro Ser Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr Arg 
                965                 970                 975     


Leu Val Lys Leu Ile Pro Gly Val Glu Tyr Leu Val Ser Ile Ile Ala 
            980                 985                 990         


Met Lys Gly Phe Glu Glu Ser Glu  Pro Val Ser Gly Ser  Phe Thr Thr 
        995                 1000                 1005             


Ala Ser  Gly Leu Asn Asp Ile  Phe Glu Ala Gln Lys  Ile Glu Trp 
    1010                 1015                 1020             


His Glu  Gly Thr His His His  His His His 
    1025                 1030             


<210>  171
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mouse TnC with C-terminal Avi- and His-tags

<400>  171

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Glu Val Pro Ser Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Ala Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Asp Asp Leu 
385                 390                 395                 400 


Ala Tyr Glu Tyr Phe Val Ile Gln Val Gln Glu Ala Asn Asn Val Glu 
                405                 410                 415     


Thr Ala His Asn Phe Thr Val Pro Gly Asn Leu Arg Ala Ala Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Val Ala Thr Ser Tyr Arg Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ala Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Thr Ser Thr Gly 
    450                 455                 460                 


Thr Thr Pro Asn Leu Gly Glu Val Thr Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Thr Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Lys Asn Phe 
                485                 490                 495     


Phe Ile Gln Val Leu Glu Ala Asp Thr Thr Gln Thr Val Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Val Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr Arg Tyr Tyr Ile Thr Leu Arg Gly Val Thr Gln Asp Phe Gly 
    530                 535                 540                 


Thr Ala Pro Leu Ser Val Glu Val Leu Thr Glu Asp Leu Pro Gln Leu 
545                 550                 555                 560 


Gly Gly Leu Ser Val Thr Glu Val Ser Trp Asp Gly Leu Thr Leu Asn 
                565                 570                 575     


Trp Thr Thr Asp Asp Leu Ala Tyr Lys His Phe Val Val Gln Val Gln 
            580                 585                 590         


Glu Ala Asn Asn Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala Asp Thr Pro Tyr Arg 
    610                 615                 620                 


Val Ser Ile Tyr Gly Val Ile Gln Gly Tyr Arg Thr Pro Met Leu Ser 
625                 630                 635                 640 


Thr Asp Val Ser Thr Ala Arg Glu Pro Glu Ile Gly Asn Leu Asn Val 
                645                 650                 655     


Ser Asp Val Thr Pro Lys Ser Phe Asn Leu Ser Trp Thr Ala Thr Asp 
            660                 665                 670         


Gly Ile Phe Asp Met Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu 
        675                 680                 685             


Leu Gln Thr Ala Glu His Asn Ile Ser Gly Ala Glu Arg Thr Ala His 
    690                 695                 700                 


Ile Ser Gly Leu Pro Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly 
705                 710                 715                 720 


Ile Ala Pro Ser Ile Arg Thr Lys Thr Ile Ser Thr Thr Ala Thr Thr 
                725                 730                 735     


Glu Ala Leu Thr Ala Met Gly Ser Pro Lys Glu Val Ile Phe Ser Asp 
            740                 745                 750         


Ile Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala Pro Thr Ala Gln 
        755                 760                 765             


Val Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr Gly Gly Thr Pro 
    770                 775                 780                 


Ser Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr Arg Leu Val Lys 
785                 790                 795                 800 


Leu Ile Pro Gly Val Glu Tyr Leu Val Ser Ile Ile Ala Met Lys Gly 
                805                 810                 815     


Phe Glu Glu Ser Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Ser Gly 
            820                 825                 830         


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Thr 
        835                 840                 845             


His His His His His His 
    850                 


<210>  172
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus TnC with C-terminal Avi- and His-tags

<400>  172

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Arg Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Phe Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln 
385                 390                 395                 400 


Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu Ala Asn Lys Val Glu 
                405                 410                 415     


Ala Ala Gln Asn Leu Thr Val Pro Gly Asn Leu Arg Ala Val Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly 
    450                 455                 460                 


Glu Thr Pro Asn Leu Gly Glu Val Met Val Ser Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Lys Leu Asn Trp Thr Val Pro Glu Gly Ala Tyr Glu Tyr Phe 
                485                 490                 495     


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn His 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
    530                 535                 540                 


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu Glu Leu Pro Gln Leu 
545                 550                 555                 560 


Gly Asp Leu Ala Val Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Ala Ala Asp Gln Ala Tyr Glu His Phe Val Ile Gln Val Gln 
            580                 585                 590         


Glu Val Asn Lys Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr 
    610                 615                 620                 


Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg Thr Pro Val Leu Ser 
625                 630                 635                 640 


Ala Glu Ala Ser Thr Ala Lys Glu Pro Glu Ile Gly Asn Leu Asn Val 
                645                 650                 655     


Ser Asp Ile Thr Pro Glu Ser Phe Ser Leu Ser Trp Thr Ala Thr Asp 
            660                 665                 670         


Gly Ile Phe Glu Thr Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu 
        675                 680                 685             


Leu Glu Ile Val Glu Tyr Asn Ile Ser Gly Ala Glu Arg Thr Ala His 
    690                 695                 700                 


Ile Ser Gly Leu Pro Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly 
705                 710                 715                 720 


Leu Ala Pro Ser Phe Arg Thr Lys Thr Ile Ser Ala Thr Ala Thr Thr 
                725                 730                 735     


Glu Ala Leu Thr Ala Met Gly Ser Pro Lys Glu Val Ile Phe Ser Asp 
            740                 745                 750         


Ile Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala Pro Thr Ala Gln 
        755                 760                 765             


Val Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr Gly Gly Thr Pro 
    770                 775                 780                 


Ser Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr Arg Leu Val Lys 
785                 790                 795                 800 


Leu Val Pro Gly Val Glu Tyr Leu Val Asn Ile Ile Ala Met Lys Gly 
                805                 810                 815     


Phe Glu Glu Ser Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Ser Gly 
            820                 825                 830         


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Thr 
        835                 840                 845             


His His His His His His 
    850                 


<210>  173
<211>  1033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST huTnC fn5 A1234 BC fn6 B

<400>  173

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln 
385                 390                 395                 400 


Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu Ala Asn Lys Val Glu 
                405                 410                 415     


Ala Ala Arg Asn Leu Thr Val Pro Gly Ser Leu Arg Ala Val Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly 
    450                 455                 460                 


Glu Thr Pro Asn Leu Gly Glu Val Val Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Lys Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Glu Tyr Phe 
                485                 490                 495     


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
    530                 535                 540                 


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu Glu Val Pro Asp Met 
545                 550                 555                 560 


Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln 
            580                 585                 590         


Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 
    610                 615                 620                 


Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu Ala 
625                 630                 635                 640 


Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu Gly Asp Leu Ala Val 
                645                 650                 655     


Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp 
            660                 665                 670         


Asn Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu Val Asn Lys Val 
        675                 680                 685             


Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser Leu Arg Ala Val Asp 
    690                 695                 700                 


Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr Arg Val Ser Ile Tyr Gly 
705                 710                 715                 720 


Val Ile Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr 
                725                 730                 735     


Ala Lys Glu Pro Glu Ile Gly Asn Leu Asn Val Ser Asp Ile Thr Pro 
            740                 745                 750         


Glu Ser Phe Asn Leu Ser Trp Met Ala Thr Asp Gly Ile Phe Glu Thr 
        755                 760                 765             


Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu Leu Glu Thr Val Glu 
    770                 775                 780                 


Tyr Asn Ile Ser Gly Ala Glu Arg Thr Ala His Ile Ser Gly Leu Pro 
785                 790                 795                 800 


Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly Leu Ala Pro Ser Ile 
                805                 810                 815     


Arg Thr Lys Thr Ile Ser Ala Thr Ala Thr Thr Glu Ala Leu Pro Leu 
            820                 825                 830         


Leu Glu Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr Gly Phe Thr Val 
        835                 840                 845             


Ser Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe Leu Val Thr Val 
    850                 855                 860                 


Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe Thr Leu Ser Gly 
865                 870                 875                 880 


Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr Gly Ile Gly Tyr 
                885                 890                 895     


Glu Val Met Val Ser Gly Phe Thr Gln Gly His Gln Thr Lys Pro Leu 
            900                 905                 910         


Arg Ala Glu Ile Val Thr Glu Ala Met Gly Ser Pro Lys Glu Val Ile 
        915                 920                 925             


Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala Pro 
    930                 935                 940                 


Thr Ala Gln Val Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr Gly 
945                 950                 955                 960 


Gly Thr Pro Ser Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr Arg 
                965                 970                 975     


Leu Val Lys Leu Ile Pro Gly Val Glu Tyr Leu Val Ser Ile Ile Ala 
            980                 985                 990         


Met Lys Gly Phe Glu Glu Ser Glu  Pro Val Ser Gly Ser  Phe Thr Thr 
        995                 1000                 1005             


Ala Ser  Gly Leu Asn Asp Ile  Phe Glu Ala Gln Lys  Ile Glu Trp 
    1010                 1015                 1020             


His Glu  Gly Thr His His His  His His His 
    1025                 1030             


<210>  174
<211>  941
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST huTnCfn5 mu A124 BC hu fn6 B

<400>  174

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Glu Val Pro Ser Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Ala Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Asp Asp Leu 
385                 390                 395                 400 


Ala Tyr Glu Tyr Phe Val Ile Gln Val Gln Glu Ala Asn Asn Val Glu 
                405                 410                 415     


Thr Ala His Asn Phe Thr Val Pro Gly Asn Leu Arg Ala Ala Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Val Ala Thr Ser Tyr Arg Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ala Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Thr Ser Thr Gly 
    450                 455                 460                 


Thr Thr Pro Asn Leu Gly Glu Val Thr Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Thr Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Lys Asn Phe 
                485                 490                 495     


Phe Ile Gln Val Leu Glu Ala Asp Thr Thr Gln Thr Val Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Val Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr Arg Tyr Tyr Ile Thr Leu Arg Gly Val Thr Gln Asp Phe Gly 
    530                 535                 540                 


Thr Ala Pro Leu Ser Val Glu Val Leu Thr Glu Asp Leu Pro Gln Leu 
545                 550                 555                 560 


Gly Gly Leu Ser Val Thr Glu Val Ser Trp Asp Gly Leu Thr Leu Asn 
                565                 570                 575     


Trp Thr Thr Asp Asp Leu Ala Tyr Lys His Phe Val Val Gln Val Gln 
            580                 585                 590         


Glu Ala Asn Asn Val Glu Ala Ala Gln Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala Asp Thr Pro Tyr Arg 
    610                 615                 620                 


Val Ser Ile Tyr Gly Val Ile Gln Gly Tyr Arg Thr Pro Met Leu Ser 
625                 630                 635                 640 


Thr Asp Val Ser Thr Ala Arg Glu Pro Glu Ile Gly Asn Leu Asn Val 
                645                 650                 655     


Ser Asp Val Thr Pro Lys Ser Phe Asn Leu Ser Trp Thr Ala Thr Asp 
            660                 665                 670         


Gly Ile Phe Asp Met Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu 
        675                 680                 685             


Leu Gln Thr Ala Glu His Asn Ile Ser Gly Ala Glu Arg Thr Ala His 
    690                 695                 700                 


Ile Ser Gly Leu Pro Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly 
705                 710                 715                 720 


Ile Ala Pro Ser Ile Arg Thr Lys Thr Ile Ser Thr Thr Ala Thr Thr 
                725                 730                 735     


Glu Ala Leu Pro Leu Leu Glu Asn Leu Thr Ile Ser Asp Thr Asn Pro 
            740                 745                 750         


Tyr Gly Phe Thr Val Ser Trp Thr Ala Ser Glu Asn Ala Phe Asp Ser 
        755                 760                 765             


Phe Leu Val Thr Val Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu 
    770                 775                 780                 


Phe Thr Leu Ser Gly Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile 
785                 790                 795                 800 


Thr Gly Ile Gly Tyr Glu Val Leu Val Ser Gly Phe Thr Gln Gly His 
                805                 810                 815     


Gln Thr Lys Pro Leu Arg Ala Glu Thr Ile Thr Ala Met Gly Ser Pro 
            820                 825                 830         


Lys Glu Val Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val Ser 
        835                 840                 845             


Trp Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr Tyr Val 
    850                 855                 860                 


Pro Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp Gly Thr Lys 
865                 870                 875                 880 


Thr Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val Glu Tyr Leu Val 
                885                 890                 895     


Ser Ile Ile Ala Met Lys Gly Phe Glu Glu Ser Glu Pro Val Ser Gly 
            900                 905                 910         


Ser Phe Thr Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys 
        915                 920                 925             


Ile Glu Trp His Glu Gly Thr His His His His His His 
    930                 935                 940     


<210>  175
<211>  668
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST TnC hu fn5 B-C fn6 B

<400>  175

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Ala Lys Glu Pro Glu Ile Gly Asn Leu Asn Val Ser 
    370                 375                 380                 


Asp Ile Thr Pro Glu Ser Phe Asn Leu Ser Trp Met Ala Thr Asp Gly 
385                 390                 395                 400 


Ile Phe Glu Thr Phe Thr Ile Glu Ile Ile Asp Ser Asn Arg Leu Leu 
                405                 410                 415     


Glu Thr Val Glu Tyr Asn Ile Ser Gly Ala Glu Arg Thr Ala His Ile 
            420                 425                 430         


Ser Gly Leu Pro Pro Ser Thr Asp Phe Ile Val Tyr Leu Ser Gly Leu 
        435                 440                 445             


Ala Pro Ser Ile Arg Thr Lys Thr Ile Ser Ala Thr Ala Thr Thr Glu 
    450                 455                 460                 


Ala Leu Pro Leu Leu Glu Asn Leu Thr Ile Ser Asp Ile Asn Pro Tyr 
465                 470                 475                 480 


Gly Phe Thr Val Ser Trp Met Ala Ser Glu Asn Ala Phe Asp Ser Phe 
                485                 490                 495     


Leu Val Thr Val Val Asp Ser Gly Lys Leu Leu Asp Pro Gln Glu Phe 
            500                 505                 510         


Thr Leu Ser Gly Thr Gln Arg Lys Leu Glu Leu Arg Gly Leu Ile Thr 
        515                 520                 525             


Gly Ile Gly Tyr Glu Val Met Val Ser Gly Phe Thr Gln Gly His Gln 
    530                 535                 540                 


Thr Lys Pro Leu Arg Ala Glu Ile Val Thr Ala Met Gly Ser Pro Lys 
545                 550                 555                 560 


Glu Val Ile Phe Ser Asp Ile Thr Glu Asn Ser Ala Thr Val Ser Trp 
                565                 570                 575     


Arg Ala Pro Thr Ala Gln Val Glu Ser Phe Arg Ile Thr Tyr Val Pro 
            580                 585                 590         


Ile Thr Gly Gly Thr Pro Ser Met Val Thr Val Asp Gly Thr Lys Thr 
        595                 600                 605             


Gln Thr Arg Leu Val Lys Leu Ile Pro Gly Val Glu Tyr Leu Val Ser 
    610                 615                 620                 


Ile Ile Ala Met Lys Gly Phe Glu Glu Ser Glu Pro Val Ser Gly Ser 
625                 630                 635                 640 


Phe Thr Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile 
                645                 650                 655     


Glu Trp His Glu Gly Thr His His His His His His 
            660                 665             


<210>  176
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GST huTnC fn5 A1234 fn6 B

<400>  176

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Leu Asp Thr 
        275                 280                 285             


Pro Lys Asp Leu Gln Val Ser Glu Thr Ala Glu Thr Ser Leu Thr Leu 
    290                 295                 300                 


Leu Trp Lys Thr Pro Leu Ala Lys Phe Asp Arg Tyr Arg Leu Asn Tyr 
305                 310                 315                 320 


Ser Leu Pro Thr Gly Gln Trp Val Gly Val Gln Leu Pro Arg Asn Thr 
                325                 330                 335     


Thr Ser Tyr Val Leu Arg Gly Leu Glu Pro Gly Gln Glu Tyr Asn Val 
            340                 345                 350         


Leu Leu Thr Ala Glu Lys Gly Arg His Lys Ser Lys Pro Ala Arg Val 
        355                 360                 365             


Lys Ala Ser Thr Glu Gln Ala Pro Glu Leu Glu Asn Leu Thr Val Thr 
    370                 375                 380                 


Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp Gln 
385                 390                 395                 400 


Ala Tyr Glu His Phe Ile Ile Gln Val Gln Glu Ala Asn Lys Val Glu 
                405                 410                 415     


Ala Ala Arg Asn Leu Thr Val Pro Gly Ser Leu Arg Ala Val Asp Ile 
            420                 425                 430         


Pro Gly Leu Lys Ala Ala Thr Pro Tyr Thr Val Ser Ile Tyr Gly Val 
        435                 440                 445             


Ile Gln Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr Gly 
    450                 455                 460                 


Glu Thr Pro Asn Leu Gly Glu Val Val Val Ala Glu Val Gly Trp Asp 
465                 470                 475                 480 


Ala Leu Lys Leu Asn Trp Thr Ala Pro Glu Gly Ala Tyr Glu Tyr Phe 
                485                 490                 495     


Phe Ile Gln Val Gln Glu Ala Asp Thr Val Glu Ala Ala Gln Asn Leu 
            500                 505                 510         


Thr Val Pro Gly Gly Leu Arg Ser Thr Asp Leu Pro Gly Leu Lys Ala 
        515                 520                 525             


Ala Thr His Tyr Thr Ile Thr Ile Arg Gly Val Thr Gln Asp Phe Ser 
    530                 535                 540                 


Thr Thr Pro Leu Ser Val Glu Val Leu Thr Glu Glu Val Pro Asp Met 
545                 550                 555                 560 


Gly Asn Leu Thr Val Thr Glu Val Ser Trp Asp Ala Leu Arg Leu Asn 
                565                 570                 575     


Trp Thr Thr Pro Asp Gly Thr Tyr Asp Gln Phe Thr Ile Gln Val Gln 
            580                 585                 590         


Glu Ala Asp Gln Val Glu Glu Ala His Asn Leu Thr Val Pro Gly Ser 
        595                 600                 605             


Leu Arg Ser Met Glu Ile Pro Gly Leu Arg Ala Gly Thr Pro Tyr Thr 
    610                 615                 620                 


Val Thr Leu His Gly Glu Val Arg Gly His Ser Thr Arg Pro Leu Ala 
625                 630                 635                 640 


Val Glu Val Val Thr Glu Asp Leu Pro Gln Leu Gly Asp Leu Ala Val 
                645                 650                 655     


Ser Glu Val Gly Trp Asp Gly Leu Arg Leu Asn Trp Thr Ala Ala Asp 
            660                 665                 670         


Asn Ala Tyr Glu His Phe Val Ile Gln Val Gln Glu Val Asn Lys Val 
        675                 680                 685             


Glu Ala Ala Gln Asn Leu Thr Leu Pro Gly Ser Leu Arg Ala Val Asp 
    690                 695                 700                 


Ile Pro Gly Leu Glu Ala Ala Thr Pro Tyr Arg Val Ser Ile Tyr Gly 
705                 710                 715                 720 


Val Ile Arg Gly Tyr Arg Thr Pro Val Leu Ser Ala Glu Ala Ser Thr 
                725                 730                 735     


Ala Lys Glu Ala Met Gly Ser Pro Lys Glu Val Ile Phe Ser Asp Ile 
            740                 745                 750         


Thr Glu Asn Ser Ala Thr Val Ser Trp Arg Ala Pro Thr Ala Gln Val 
        755                 760                 765             


Glu Ser Phe Arg Ile Thr Tyr Val Pro Ile Thr Gly Gly Thr Pro Ser 
    770                 775                 780                 


Met Val Thr Val Asp Gly Thr Lys Thr Gln Thr Arg Leu Val Lys Leu 
785                 790                 795                 800 


Ile Pro Gly Val Glu Tyr Leu Val Ser Ile Ile Ala Met Lys Gly Phe 
                805                 810                 815     


Glu Glu Ser Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Ser Gly Leu 
            820                 825                 830         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Thr His 
        835                 840                 845             


His His His His His 
    850             


<210>  177
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huTnC A4 B

<400>  177

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Asp Leu Pro 
        275                 280                 285             


Gln Leu Gly Asp Leu Ala Val Ser Glu Val Gly Trp Asp Gly Leu Arg 
    290                 295                 300                 


Leu Asn Trp Thr Ala Ala Asp Asn Ala Tyr Glu His Phe Val Ile Gln 
305                 310                 315                 320 


Val Gln Glu Val Asn Lys Val Glu Ala Ala Gln Asn Leu Thr Leu Pro 
                325                 330                 335     


Gly Ser Leu Arg Ala Val Asp Ile Pro Gly Leu Glu Ala Ala Thr Pro 
            340                 345                 350         


Tyr Arg Val Ser Ile Tyr Gly Val Ile Arg Gly Tyr Arg Thr Pro Val 
        355                 360                 365             


Leu Ser Ala Glu Ala Ser Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu 
    370                 375                 380                 


Ala Gln Lys Ile Glu Trp His Glu Gly Thr His His His His His His 
385                 390                 395                 400 


<210>  178
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huTnC A1 B

<400>  178

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gly Ser Thr Ser 
    210                 215                 220                 


Gly Ser Gly His His His His His His Ser Ala Gly Leu Val Pro Arg 
225                 230                 235                 240 


Gly Ser Thr Ala Ile Gly Met Lys Glu Thr Ala Ala Ala Lys Phe Glu 
                245                 250                 255     


Arg Gln His Met Asp Ser Pro Asp Leu Gly Thr Gly Gly Gly Ser Gly 
            260                 265                 270         


Ile Glu Gly Arg Gly Ser Met Gly Tyr Arg Gly Ser Glu Gln Ala Pro 
        275                 280                 285             


Glu Leu Glu Asn Leu Thr Val Thr Glu Val Gly Trp Asp Gly Leu Arg 
    290                 295                 300                 


Leu Asn Trp Thr Ala Ala Asp Gln Ala Tyr Glu His Phe Ile Ile Gln 
305                 310                 315                 320 


Val Gln Glu Ala Asn Lys Val Glu Ala Ala Arg Asn Leu Thr Val Pro 
                325                 330                 335     


Gly Ser Leu Arg Ala Val Asp Ile Pro Gly Leu Lys Ala Ala Thr Pro 
            340                 345                 350         


Tyr Thr Val Ser Ile Tyr Gly Val Ile Gln Gly Tyr Arg Thr Pro Val 
        355                 360                 365             


Leu Ser Ala Glu Ala Ser Thr Ala Ser Gly Leu Asn Asp Ile Phe Glu 
    370                 375                 380                 


Ala Gln Lys Ile Glu Trp His Glu Gly Thr His His His His His His 
385                 390                 395                 400 


<210>  179
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4)  VL

<400>  179
gacatccaga tgacccagtc tccatccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag aataagaagt ttccttcggg gacgtttggc      300

cagggcacca aagtcgagat caag                                             324


<210>  180
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4)  VH

<400>  180
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctca            354


<210>  181
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7)  VL

<400>  181
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcagggtc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactccatt aatagtactc gtaatgaggt attcggcgga      300

gggaccaagc tgaccgtcct a                                                321


<210>  182
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7)  VH

<400>  182
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccaaagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaacttct      300

ccgcgtgttc cgctggacta ctggggccaa ggaaccctgg tcaccgtctc gagt            354


<210>  183
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4)  CDR-L1

<400>  183
cgtgccagtc agagtattag tagctggttg gcc                                    33


<210>  184
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7)  CDR-L1

<400>  184
caaggagaca gcctcagaag ttattatgca agc                                    33


<210>  185
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4)  CDR-L2

<400>  185
gatgcctcca gtttggaaag t                                                 21


<210>  186
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7)  CDR-L2

<400>  186
ggtaaaaaca accggccctc a                                                 21


<210>  187
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4)  CDR-L3

<400>  187
caacagaata agaagtttcc ttcggggacg                                        30


<210>  188
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7)  CDR-L3

<400>  188
aactccatta atagtactcg taatgaggta                                        30


<210>  189
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4)  CDR-H1

<400>  189
agctacgcta taagc                                                        15


<210>  190
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7)  CDR-H1

<400>  190
ggattcacct ttagcagtta tgccatgagc                                        30


<210>  191
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4)  CDR-H2

<400>  191
gggatcatcc ctatctttgg tacagcaaac tacgcacaga agttccaggg c                51


<210>  192
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7)  CDR-H2

<400>  192
gctattagcg gtagtggtgg tagcacatac tacgcagact ccgtgaaggg c                51


<210>  193
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4)  CDR-H3

<400>  193
ggtaacttct acggtggtct ggactac                                           27


<210>  194
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7)  CDR-H3

<400>  194
acttctccgc gtgttccgct ggactac                                           27


<210>  195
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4) light chain in human IgG1 format

<400>  195
gacatccaga tgacccagtc tccatccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag aataagaagt ttccttcggg gacgtttggc      300

cagggcacca aagtcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  196
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4) heavy chain in human IgG1 format

<400>  196
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  197
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7) light chain in human IgG1 format

<400>  197
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcagggtc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactccatt aatagtactc gtaatgaggt attcggcgga      300

gggaccaagc tgaccgtcct aggtcaaccc aaggctgccc ccagcgtgac cctgttcccc      360

cccagcagcg aggaactgca ggccaacaag gccaccctgg tctgcctgat cagcgacttc      420

tacccaggcg ccgtgaccgt ggcctggaag gccgacagca gccccgtgaa ggccggcgtg      480

gagaccacca cccccagcaa gcagagcaac aacaagtacg ccgccagcag ctacctgagc      540

ctgacccccg agcagtggaa gagccacagg tcctacagct gccaggtgac ccacgagggc      600

agcaccgtgg agaaaaccgt ggcccccacc gagtgcagc                             639


<210>  198
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7) heavy chain in human IgG1 format

<400>  198
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccaaagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaacttct      300

ccgcgtgttc cgctggacta ctggggccaa ggaaccctgg tcaccgtctc gagtgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  199
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4) light chain in human IgG1 format

<400>  199

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Lys Lys Phe Pro Ser 
                85                  90                  95      


Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  200
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4) heavy chain in human IgG1 format

<400>  200

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  201
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7) light chain in human IgG1 format

<400>  201

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ile Asn Ser Thr Arg Asn Glu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  202
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7) heavy chain in human IgG1 format

<400>  202

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Ser Pro Arg Val Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  203
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(18D4) heavy chain in P329GLALA human IgG1
       format

<400>  203
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  204
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence TnC(11C7) heavy chain in P329GLALA human IgG1
       format

<400>  204
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagcggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccaaagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaacttct      300

ccgcgtgttc cgctggacta ctggggccaa ggaaccctgg tcaccgtctc gagtgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  205
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(18D4) heavy chain in P329GLALA human IgG1 format

<400>  205

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  206
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TnC(11C7) heavy chain in P329GLALA human IgG1 format

<400>  206

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Ser Pro Arg Val Pro Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  207
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence LC1 (pCON323) OX40 (49B4) VL/CL

<400>  207
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatagttcgc agccgtatac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  208
<211>  2079
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Heavy chain pETR14728 OX40 (49B4) 
       VHCH1_Fc_PGLALA_TnC (18D4) VHCL

<400>  208
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catccgtgtt ccctctggcc ccttccagca agtctacctc tggcggcaca      420

gccgctctgg gctgcctcgt gaaggactac ttccccgagc ctgtgacagt gtcctggaac      480

tctggcgccc tgacatccgg cgtgcacacc tttccagctg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtcgt gacagtgccc tccagctctc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga acccaagtcc      660

tgcgacaaga cccacacctg tcccccttgt cctgcccctg aagctgctgg cggccctagc      720

gtgttcctgt tccccccaaa gcccaaggac accctgatga tctcccggac ccccgaagtg      780

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa tgccaagacc aagcctagag aggaacagta caactccacc      900

taccgggtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaagagtac      960

aagtgcaagg tgtccaacaa ggccctggga gcccccatcg aaaagaccat ctccaaggcc     1020

aagggccagc ctcgcgagcc tcaggtgtac accctgcccc ctagcagaga tgagctgacc     1080

aagaaccagg tgtccctgac ctgtctcgtg aaaggcttct acccctccga tatcgccgtg     1140

gaatgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc tgtgctggac     1200

tccgacggct cattcttcct gtactctaag ctgacagtgg acaagtcccg gtggcagcag     1260

ggcaacgtgt tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgtccc tgtctcccgg gggaggcggt ggatctggcg gaggcggatc cggtggtggc     1380

ggttccgggg gcggtggatc gcaggtgcaa ttggtgcagt ctggggctga ggtgaagaag     1440

cctgggtcct cggtgaaggt ctcctgcaag gcctccggag gcacattcag cagctacgct     1500

ataagctggg tgcgacaggc ccctggacaa gggctcgagt ggatgggagg gatcatccct     1560

atctttggta cagcaaacta cgcacagaag ttccagggca gggtcaccat tactgcagac     1620

aaatccacga gcacagccta catggagctg agcagcctga gatctgagga caccgccgtg     1680

tattactgtg cgaaaggtaa cttctacggt ggtctggact actggggcca agggaccacc     1740

gtgaccgtct ccagcgcttc tgtggccgct ccctccgtgt tcatcttccc accttccgac     1800

gagcagctga agtccggcac tgcctctgtc gtgtgcctgc tgaacaactt ctaccctcgg     1860

gaagccaagg tgcagtggaa agtggataac gccctgcagt ccggcaactc ccaggaatcc     1920

gtgaccgagc aggactccaa ggacagcacc tactccctga gcagcaccct gaccctgtcc     1980

aaggccgact acgagaagca caaggtgtac gcctgtgaag tgacccacca gggcctgtcc     2040

agccccgtga ccaagtcctt caaccggggc gagtgctga                            2079


<210>  209
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence LC2 pETR14647 TnC (18D4) VLCH1

<400>  209
gacatccaga tgacccagtc tccatccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag aataagaagt ttccttcggg gacgtttggc      300

cagggcacca aagtcgagat caagagctcc gctagcacca agggcccctc cgtgtttcct      360

ctggccccca gcagcaagag cacctctggc ggaacagccg ccctgggctg cctggtgaaa      420

gactacttcc ccgagcccgt gaccgtgtcc tggaactctg gcgccctgac cagcggcgtg      480

cacacctttc cagccgtgct gcagagcagc ggcctgtact ccctgagcag cgtggtgaca      540

gtgccctcca gcagcctggg cacccagacc tacatctgca acgtgaacca caagcccagc      600

aacaccaaag tggacaagaa ggtggaaccc aagagctgcg ac                         642


<210>  210
<211>  2076
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Heavy chain pETR14727 OX40 (49B4) 
       VHCH1_Fc_PG/LALA_TnC (11C7) VHCL

<400>  210
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catccgtgtt ccctctggcc ccttccagca agtctacctc tggcggcaca      420

gccgctctgg gctgcctcgt gaaggactac ttccccgagc ctgtgacagt gtcctggaac      480

tctggcgccc tgacatccgg cgtgcacacc tttccagctg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtcgt gacagtgccc tccagctctc tgggcaccca gacctacatt      600

tgcaacgtga accacaagcc ctccaacacc aaggtggaca agaaggtgga acccaagtcc      660

tgcgacaaga cccacacctg tcccccttgt cctgcccctg aagctgctgg cggccctagc      720

gtgttcctgt tccccccaaa gcccaaggac accctgatga tctcccggac ccccgaagtg      780

acctgcgtgg tggtggatgt gtcccacgag gaccctgaag tgaagttcaa ttggtacgtg      840

gacggcgtgg aagtgcacaa tgccaagacc aagcctagag aggaacagta caactccacc      900

taccgggtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaagagtac      960

aagtgcaagg tgtccaacaa ggccctggga gcccccatcg aaaagaccat ctccaaggcc     1020

aagggccagc ctcgcgagcc tcaggtgtac accctgcccc ctagcagaga tgagctgacc     1080

aagaaccagg tgtccctgac ctgtctcgtg aaaggcttct acccctccga tatcgccgtg     1140

gaatgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc tgtgctggac     1200

tccgacggct cattcttcct gtactctaag ctgacagtgg acaagtcccg gtggcagcag     1260

ggcaacgtgt tctcctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag     1320

tccctgtccc tgtctcccgg gggaggcggt ggatctggcg gaggcggatc cggtggtggc     1380

ggttccgggg gcggtggatc ggaggtgcaa ttgttggagt ctgggggagg cttggtacag     1440

cctggggggt ccctgagact ctcctgtgca gcctccggat tcacctttag cagttatgcc     1500

atgagctggg tccgccaggc tccagggaag gggctggagt gggtctcagc tattagcggt     1560

agtggtggta gcacatacta cgcagactcc gtgaagggcc ggttcaccat ctccaaagac     1620

aattccaaga acacgctgta tctgcagatg aacagcctga gagccgagga cacggccgta     1680

tattactgtg cgaaaacttc tccgcgtgtt ccgctggact actggggcca aggaaccctg     1740

gtcaccgtct cgagcgcttc tgtggccgct ccctccgtgt tcatcttccc accttccgac     1800

gagcagctga agtccggcac tgcctctgtc gtgtgcctgc tgaacaactt ctaccctcgg     1860

gaagccaagg tgcagtggaa agtggataac gccctgcagt ccggcaactc ccaggaatcc     1920

gtgaccgagc aggactccaa ggacagcacc tactccctga gcagcaccct gaccctgtcc     1980

aaggccgact acgagaagca caaggtgtac gcctgtgaag tgacccacca gggcctgtcc     2040

agccccgtga ccaagtcctt caaccggggc gagtgc                               2076


<210>  211
<211>  643
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence LC2 pETR14648 TnC (11C7) VLCH1

<400>  211
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcagggtc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactccatt aatagtactc gtaatgaggt attcggcgga      300

gggaccaagc tgaccgtcct aagctccgct agcaccaagg gcccctccgt gtttcctctg      360

gcccccagca gcaagagcac ctctggcgga acagccgccc tgggctgcct ggtgaaagac      420

tacttccccg agcccgtgac cgtgtcctgg aactctggcg ccctgaccag cggcgtgcac      480

acctttccag ccgtgctgca gagcagcggc ctgtactccc tgagcagcgt ggtgacagtg      540

ccctccagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaac      600

accaaagtgg acaagaaggt ggaacccaag agctgcgact gat                        643


<210>  212
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC1 (pCON323) OX40 (49B4) VL/CL

<400>  212

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  213
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain pETR14728 OX40 (49B4) VHCH1_Fc_PG/LALA_TnC (18D4) 
       VHCL

<400>  213

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
465                 470                 475                 480 


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
                485                 490                 495     


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
            500                 505                 510         


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
        515                 520                 525             


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
    530                 535                 540                 


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
545                 550                 555                 560 


Tyr Tyr Cys Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly 
                565                 570                 575     


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser 
            580                 585                 590         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        595                 600                 605             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    610                 615                 620                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
625                 630                 635                 640 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                645                 650                 655     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            660                 665                 670         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        675                 680                 685             


Arg Gly Glu Cys 
    690         


<210>  214
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC2 pETR14647 TnC (18D4) VLCH1

<400>  214

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Lys Lys Phe Pro Ser 
                85                  90                  95      


Gly Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        115                 120                 125             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            180                 185                 190         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
        195                 200                 205             


Glu Pro Lys Ser Cys Asp 
    210                 


<210>  215
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain pETR14727 OX40 (49B4) VHCH1_Fc_PG/LALA_TnC (11C7) 
       VHCL

<400>  215

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
465                 470                 475                 480 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                485                 490                 495     


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            500                 505                 510         


Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala 
        515                 520                 525             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn 
    530                 535                 540                 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
545                 550                 555                 560 


Tyr Tyr Cys Ala Lys Thr Ser Pro Arg Val Pro Leu Asp Tyr Trp Gly 
                565                 570                 575     


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser 
            580                 585                 590         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        595                 600                 605             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    610                 615                 620                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
625                 630                 635                 640 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                645                 650                 655     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            660                 665                 670         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        675                 680                 685             


Arg Gly Glu Cys 
    690         


<210>  216
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC2 pETR14648 TnC (11C7) VLCH1

<400>  216

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Val Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Ile Asn Ser Thr Arg Asn Glu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        115                 120                 125             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                165                 170                 175     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            180                 185                 190         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
        195                 200                 205             


Pro Lys Ser Cys Asp 
    210             


<210>  217
<211>  2421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence HC1 pETR15193 OX40 (49B4) 
       VHCH1_VHCH1_Fc_hole_PG/LALA_TnC (18D4) VL

<400>  217
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

acaaagggac ctagcgtgtt ccccctggcc cccagcagca agtctacatc tggcggaaca      420

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactctctga gcagcgtcgt gacagtgccc agcagctctc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga acccaagagc      660

tgcgacggcg gagggggatc tggcggcgga ggatcccagg tgcaattggt gcagtctggg      720

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcctc cggaggcaca      780

ttcagcagct acgctataag ctgggtgcga caggcccctg gacaagggct cgagtggatg      840

ggagggatca tccctatctt tggtacagca aactacgcac agaagttcca gggcagggtc      900

accattactg cagacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct      960

gaggacaccg ccgtgtatta ctgtgcgaga gaatactacc gtggtccgta cgactactgg     1020

ggccaaggga ccaccgtgac cgtctcctca gctagcacca agggcccatc ggtcttcccc     1080

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag     1140

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg     1200

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc     1260

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc     1320

aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca cacatgccca     1380

ccgtgcccag cacctgaagc tgcaggggga ccgtcagtct tcctcttccc cccaaaaccc     1440

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1500

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1560

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1620

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1680

ctcggcgccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1740

gtgtgcaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctctcgtgc     1800

gcagtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1860

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctcgtg     1920

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1980

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtgga     2040

ggcggcggaa gcggaggagg aggatccggc ggcggaggtt ccggaggcgg tggatcggac     2100

atccagatga cccagtctcc atccaccctg tctgcatctg taggagaccg tgtcaccatc     2160

acttgccgtg ccagtcagag tattagtagc tggttggcct ggtatcagca gaaaccaggg     2220

aaagccccta agctcctgat ctatgatgcc tccagtttgg aaagtggggt cccatcacgt     2280

ttcagcggca gtggatccgg gacagaattc actctcacca tcagcagctt gcagcctgat     2340

gattttgcaa cttattactg ccaacagaat aagaagtttc cttcggggac gtttggccag     2400

ggcaccaaag tcgagatcaa g                                               2421


<210>  218
<211>  2451
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence HC2 pETR15194 OX40 (49B4) 
       VHCH1_VHCH1_Fc_knob_PG/LALA_ TnC (18D4) VH

<400>  218
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

acaaagggac ctagcgtgtt ccccctggcc cccagcagca agtctacatc tggcggaaca      420

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactctctga gcagcgtcgt gacagtgccc agcagctctc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga acccaagagc      660

tgcgacggcg gagggggatc tggcggcgga ggatcccagg tgcaattggt gcagtctggg      720

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcctc cggaggcaca      780

ttcagcagct acgctataag ctgggtgcga caggcccctg gacaagggct cgagtggatg      840

ggagggatca tccctatctt tggtacagca aactacgcac agaagttcca gggcagggtc      900

accattactg cagacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct      960

gaggacaccg ccgtgtatta ctgtgcgaga gaatactacc gtggtccgta cgactactgg     1020

ggccaaggga ccaccgtgac cgtctcctca gctagcacca agggcccatc ggtcttcccc     1080

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag     1140

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg     1200

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc     1260

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc     1320

aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca cacatgccca     1380

ccgtgcccag cacctgaagc tgcaggggga ccgtcagtct tcctcttccc cccaaaaccc     1440

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1500

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1560

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1620

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1680

ctcggcgccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1740

gtgtacaccc tgcccccctg cagagatgag ctgaccaaga accaggtgtc cctgtggtgt     1800

ctggtcaagg gcttctaccc cagcgatatc gccgtggagt gggagagcaa cggccagcct     1860

gagaacaact acaagaccac cccccctgtg ctggacagcg acggcagctt cttcctgtac     1920

tccaaactga ccgtggacaa gagccggtgg cagcagggca acgtgttcag ctgcagcgtg     1980

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgagcctgag ccccggcgga     2040

ggcggcggaa gcggaggagg aggatccggt ggtggcggtt ccgggggcgg tggatcgcag     2100

gtgcaattgg tgcagtctgg ggctgaggtg aagaagcctg ggtcctcggt gaaggtctcc     2160

tgcaaggcct ccggaggcac attcagcagc tacgctataa gctgggtgcg acaggcccct     2220

ggacaagggc tcgagtggat gggagggatc atccctatct ttggtacagc aaactacgca     2280

cagaagttcc agggcagggt caccattact gcagacaaat ccacgagcac agcctacatg     2340

gagctgagca gcctgagatc tgaggacacc gccgtgtatt actgtgcgaa aggtaacttc     2400

tacggtggtc tggactactg gggccaaggg accacagtga ccgtaagctc c              2451


<210>  219
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence LC1 pETR14912 OX40 (49B4) VLCL + charges

<400>  219
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatagttcgc agccgtatac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatcgga agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  220
<211>  2736
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence HC pETR15206 OX40 
       (49B4)VHCH1EE_OX40(49B4)VHCH1EE_Fc_PG/LALA_TnC (18D4)VLCH1

<400>  220
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ccggcagcag cgtgaaggtg       60

tcctgcaagg cttccggcgg caccttcagc agctacgcca tttcttgggt gcgccaggcc      120

cctggacagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgaca agagcaccag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagagagtac      300

tacagaggcc cctacgacta ctggggccag ggcacaaccg tgaccgtgtc tagcgccagc      360

acaaagggcc ccagcgtgtt ccctctggcc cctagcagca agagcacatc tggcggaaca      420

gccgccctgg gctgcctggt ggaagattac ttccccgagc ccgtgacagt gtcctggaac      480

tctggcgccc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactcactgt ccagcgtcgt gactgtgccc agcagcagcc tgggaaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggacg agaaggtgga acccaagagc      660

tgcgacggcg gaggcggatc tggcggcgga ggatcccagg tgcagctggt gcagagcgga      720

gctgaagtga aaaagcctgg ctcctccgtg aaagtgtctt gtaaagccag cggcggcaca      780

ttctcatcct acgccatcag ctgggtgcgg caggctccag gccagggact ggaatggatg      840

ggaggaatta tccctatttt tgggacagcc aattatgctc agaaatttca ggggcgcgtg      900

acaattacag ccgacaagtc cacctctaca gcttatatgg aactgtcctc cctgcgctcc      960

gaggatacag ctgtgtatta ttgtgcccgc gagtactacc ggggacctta cgattattgg     1020

ggacagggaa ccacagtgac tgtgtcctcc gctagcacca agggaccttc cgtgtttccc     1080

ctggctccca gctccaagtc tacctctggg ggcacagctg ctctgggatg tctggtggaa     1140

gattattttc ctgaacctgt gaccgtgtca tggaacagcg gagccctgac ctccggggtg     1200

cacacattcc ctgctgtgct gcagtcctcc ggcctgtata gcctgagcag cgtcgtgacc     1260

gtgccttcca gctctctggg cacacagaca tatatctgta atgtgaatca caaaccctct     1320

aataccaaag tggatgagaa agtggaacct aagtcctgcg acaagaccca cacctgtccc     1380

ccttgtcctg cccctgaagc tgctggcggc ccatctgtgt ttctgttccc cccaaagccc     1440

aaggacaccc tgatgatcag ccggaccccc gaagtgacct gcgtggtggt ggatgtgtcc     1500

cacgaggacc cagaagtgaa gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc     1560

aagaccaagc cgcgggaaga acagtacaac agcacctacc gggtggtgtc cgtgctgaca     1620

gtgctgcacc aggactggct gaacggcaaa gagtacaagt gcaaggtgtc caacaaggcc     1680

ctgggagccc ccatcgagaa aaccatcagc aaggccaagg gccagccccg cgaacctcag     1740

gtgtacaccc tgcccccaag cagggacgag ctgaccaaga accaggtgtc cctgacctgt     1800

ctcgtgaagg gcttctaccc ctccgatatc gccgtggaat gggagagcaa cggccagccc     1860

gagaacaact acaagaccac cccccctgtg ctggacagcg acggctcatt cttcctgtac     1920

tccaagctga ccgtggacaa gagccggtgg cagcagggca acgtgttcag ctgcagcgtg     1980

atgcacgagg ccctgcacaa ccactacaca cagaagtctc tgagcctgag ccctggcgga     2040

gggggaggat ctgggggagg cggaagtggg ggagggggtt ccggaggcgg tggatcggac     2100

atccagatga cccagtctcc atccaccctg tctgcatctg taggagaccg tgtcaccatc     2160

acttgccgtg ccagtcagag tattagtagc tggttggcct ggtatcagca gaaaccaggg     2220

aaagccccta agctcctgat ctatgatgcc tccagtttgg aaagtggggt cccatcacgt     2280

ttcagcggca gtggatccgg gacagaattc actctcacca tcagcagctt gcagcctgat     2340

gattttgcaa cttattactg ccaacagaat aagaagtttc cttcggggac gtttggccag     2400

ggcaccaaag tcgagatcaa gtctagcgct tccaccaagg gcccctcagt gttcccactg     2460

gcaccatcca gcaagtccac aagcggagga accgccgctc tgggctgtct cgtgaaagac     2520

tactttccag agccagtgac cgtgtcctgg aatagtggcg ctctgacttc tggcgtgcac     2580

actttccccg cagtgctgca gagttctggc ctgtactccc tgagtagcgt cgtgacagtg     2640

ccctcctcta gcctgggcac tcagacttac atctgcaatg tgaatcataa gccttccaac     2700

acaaaagtgg acaaaaaagt ggaacccaaa tcttgc                               2736


<210>  221
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence LC2 pETR15202 TnC (18D4) VHCL

<400>  221
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gaaaggtaac      300

ttctacggtg gtctggacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

gtggccgctc cctccgtgtt catcttccca ccttccgacg agcagctgaa gtccggcacc      420

gcttctgtcg tgtgcctgct gaacaacttc tacccccgcg aggccaaggt gcagtggaag      480

gtggacaacg ccctgcagtc cggcaacagc caggaatccg tgaccgagca ggactccaag      540

gacagcacct actccctgtc ctccaccctg accctgtcca aggccgacta cgagaagcac      600

aaggtgtacg cctgcgaagt gacccaccag ggcctgtcta gccccgtgac caagtctttc      660

aaccggggcg agtgc                                                       675


<210>  222
<211>  807
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC1 pETR15193 OX40 (49B4) VHCH1_VHCH1_Fc_hole_PG/LALA_TnC (18D4) 
       VL

<400>  222

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
225                 230                 235                 240 


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
        275                 280                 285             


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
    290                 295                 300                 


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
305                 310                 315                 320 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Tyr Arg Gly Pro 
                325                 330                 335     


Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
            340                 345                 350         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        355                 360                 365             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    370                 375                 380                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
385                 390                 395                 400 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                405                 410                 415     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            420                 425                 430         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
        435                 440                 445             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    450                 455                 460                 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
465                 470                 475                 480 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                485                 490                 495     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            500                 505                 510         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        515                 520                 525             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    530                 535                 540                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
545                 550                 555                 560 


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                565                 570                 575     


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            580                 585                 590         


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
        595                 600                 605             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    610                 615                 620                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
625                 630                 635                 640 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                645                 650                 655     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            660                 665                 670         


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    690                 695                 700                 


Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
705                 710                 715                 720 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
                725                 730                 735     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
            740                 745                 750         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        755                 760                 765             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    770                 775                 780                 


Tyr Tyr Cys Gln Gln Asn Lys Lys Phe Pro Ser Gly Thr Phe Gly Gln 
785                 790                 795                 800 


Gly Thr Lys Val Glu Ile Lys 
                805         


<210>  223
<211>  817
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC2 pETR15194 OX40 (49B4) VHCH1_VHCH1_Fc_knob_PG/LALA_ TnC (18D4)
       VH

<400>  223

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
225                 230                 235                 240 


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
        275                 280                 285             


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
    290                 295                 300                 


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
305                 310                 315                 320 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Tyr Arg Gly Pro 
                325                 330                 335     


Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
            340                 345                 350         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        355                 360                 365             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    370                 375                 380                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
385                 390                 395                 400 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                405                 410                 415     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            420                 425                 430         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
        435                 440                 445             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    450                 455                 460                 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
465                 470                 475                 480 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                485                 490                 495     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            500                 505                 510         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        515                 520                 525             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    530                 535                 540                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
545                 550                 555                 560 


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                565                 570                 575     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
            580                 585                 590         


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        595                 600                 605             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    610                 615                 620                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
625                 630                 635                 640 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                645                 650                 655     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            660                 665                 670         


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    690                 695                 700                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
705                 710                 715                 720 


Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val 
                725                 730                 735     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro 
            740                 745                 750         


Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
        755                 760                 765             


Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    770                 775                 780                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Asn Phe 
785                 790                 795                 800 


Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
                805                 810                 815     


Ser 
    


<210>  224
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC1 pETR14912 OX40 (49B4) VLCL + charges

<400>  224

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Arg Lys Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  225
<211>  912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC pETR15206 OX40 (49B4)VHCH1EE_OX40(49B4)VHCH1EE_Fc_PG/LALA_TnC 
       (18D4)VLCH1

<400>  225

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Glu Lys Val Glu Pro Lys Ser Cys Asp Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
225                 230                 235                 240 


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
        275                 280                 285             


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
    290                 295                 300                 


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
305                 310                 315                 320 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Tyr Arg Gly Pro 
                325                 330                 335     


Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
            340                 345                 350         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        355                 360                 365             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe Pro 
    370                 375                 380                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
385                 390                 395                 400 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                405                 410                 415     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            420                 425                 430         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Glu Lys Val 
        435                 440                 445             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    450                 455                 460                 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
465                 470                 475                 480 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                485                 490                 495     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            500                 505                 510         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        515                 520                 525             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    530                 535                 540                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
545                 550                 555                 560 


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                565                 570                 575     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            580                 585                 590         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        595                 600                 605             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    610                 615                 620                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
625                 630                 635                 640 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                645                 650                 655     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            660                 665                 670         


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    690                 695                 700                 


Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
705                 710                 715                 720 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln 
                725                 730                 735     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
            740                 745                 750         


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        755                 760                 765             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    770                 775                 780                 


Tyr Tyr Cys Gln Gln Asn Lys Lys Phe Pro Ser Gly Thr Phe Gly Gln 
785                 790                 795                 800 


Gly Thr Lys Val Glu Ile Lys Ser Ser Ala Ser Thr Lys Gly Pro Ser 
                805                 810                 815     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            820                 825                 830         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        835                 840                 845             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    850                 855                 860                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
865                 870                 875                 880 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                885                 890                 895     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            900                 905                 910         


<210>  226
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC2 pETR15202 TnC (18D4) VHCL

<400>  226

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Asn Phe Tyr Gly Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
    130                 135                 140                 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
145                 150                 155                 160 


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
                165                 170                 175     


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
            180                 185                 190         


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
        195                 200                 205             


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
    210                 215                 220                 


Cys 
225 


