                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Trimeric Antigen Binding Molecules specific for a costimulatory 
       TNF receptor

<130>  P34210-WO

<150>  EP17163619.4
<151>  2017-03-29

<160>  253   

<170>  PatentIn version 3.5

<210>  1
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Val Leu Ser Gly Thr Ser Leu Met Leu Cys Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gln Ala Leu Cys Ser Pro Gly Leu Ala Pro Gln Ser Arg Gly 
            20                  25                  30          


His Leu Cys Arg Thr Arg Pro Thr Asp Leu Val Phe Val Val Asp Ser 
        35                  40                  45              


Ser Arg Ser Val Arg Pro Val Glu Phe Glu Lys Val Lys Val Phe Leu 
    50                  55                  60                  


Ser Gln Val Ile Glu Ser Leu Asp Val Gly Pro Asn Ala Thr Arg Val 
65                  70                  75                  80  


Gly Met Val Asn Tyr Ala Ser Thr Val Lys Gln Glu Phe Ser Leu Arg 
                85                  90                  95      


Ala His Val Ser Lys Ala Ala Leu Leu Gln Ala Val Arg Arg Ile Gln 
            100                 105                 110         


Pro Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Phe Ala Ile 
        115                 120                 125             


Thr Lys Ala Phe Gly Asp Ala Glu Gly Gly Arg Ser Arg Ser Pro Asp 
    130                 135                 140                 


Ile Ser Lys Val Val Ile Val Val Thr Asp Gly Arg Pro Gln Asp Ser 
145                 150                 155                 160 


Val Gln Asp Val Ser Ala Arg Ala Arg Ala Ser Gly Val Glu Leu Phe 
                165                 170                 175     


Ala Ile Gly Val Gly Ser Val Asp Lys Ala Thr Leu Arg Gln Ile Ala 
            180                 185                 190         


Ser Glu Pro Gln Asp Glu His Val Asp Tyr Val Glu Ser Tyr Ser Val 
        195                 200                 205             


Ile Glu Lys Leu Ser Arg Lys Phe Gln Glu Ala Phe Cys Val Val Ser 
    210                 215                 220                 


Asp Leu Cys Ala Thr Gly Asp His Asp Cys Glu Gln Val Cys Ile Ser 
225                 230                 235                 240 


Ser Pro Gly Ser Tyr Thr Cys Ala Cys His Glu Gly Phe Thr Leu Asn 
                245                 250                 255     


Ser Asp Gly Lys Thr Cys Asn Val Cys Ser Gly Gly Gly Gly Ser Ser 
            260                 265                 270         


Ala Thr Asp Leu Val Phe Leu Ile Asp Gly Ser Lys Ser Val Arg Pro 
        275                 280                 285             


Glu Asn Phe Glu Leu Val Lys Lys Phe Ile Ser Gln Ile Val Asp Thr 
    290                 295                 300                 


Leu Asp Val Ser Asp Lys Leu Ala Gln Val Gly Leu Val Gln Tyr Ser 
305                 310                 315                 320 


Ser Ser Val Arg Gln Glu Phe Pro Leu Gly Arg Phe His Thr Lys Lys 
                325                 330                 335     


Asp Ile Lys Ala Ala Val Arg Asn Met Ser Tyr Met Glu Lys Gly Thr 
            340                 345                 350         


Met Thr Gly Ala Ala Leu Lys Tyr Leu Ile Asp Asn Ser Phe Thr Val 
        355                 360                 365             


Ser Ser Gly Ala Arg Pro Gly Ala Gln Lys Val Gly Ile Val Phe Thr 
    370                 375                 380                 


Asp Gly Arg Ser Gln Asp Tyr Ile Asn Asp Ala Ala Lys Lys Ala Lys 
385                 390                 395                 400 


Asp Leu Gly Phe Lys Met Phe Ala Val Gly Val Gly Asn Ala Val Glu 
                405                 410                 415     


Asp Glu Leu Arg Glu Ile Ala Ser Glu Pro Val Ala Glu His Tyr Phe 
            420                 425                 430         


Tyr Thr Ala Asp Phe Lys Thr Ile Asn Gln Ile Gly Lys Lys Leu Gln 
        435                 440                 445             


Lys Lys Ile Cys Val Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu Val 
    450                 455                 460                 


Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys 
465                 470                 475                 480 


Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val Val 
                485                 490                 495     


<210>  2
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Ala Cys Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu 
1               5                   10                  15      


Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala 
            20                  25                  30          


Ile Leu Glu Asn Thr Val Val 
        35                  


<210>  3
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala 
            180                 185     


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-H1

<400>  4

Ser Tyr Ala Ile Ser 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC-564, 17A9)  CDR-H1

<400>  5

Ser Tyr Ala Met Ser 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-H2

<400>  6

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC-564, 17A9)  CDR-H2

<400>  7

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  CDR-H3

<400>  8

Glu Tyr Gly Trp Met Asp Tyr 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  CDR-H3

<400>  9

Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr 
1               5                   


<210>  10
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  CDR-H3

<400>  10

Glu Tyr Gly Ser Met Asp Tyr 
1               5           


<210>  11
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  CDR-H3

<400>  11

Val Asn Tyr Pro Tyr Ser Tyr Trp Gly Asp Phe Asp Tyr 
1               5                   10              


<210>  12
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563)  CDR-H3

<400>  12

Asp Val Gly Ala Phe Asp Tyr 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-564)  CDR-H3

<400>  13

Asp Val Gly Pro Phe Asp Tyr 
1               5           


<210>  14
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9)-CDR-H3

<400>  14

Val Phe Tyr Arg Gly Gly Val Ser Met Asp Tyr 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-L1

<400>  15

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  16
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC564)  CDR-L1

<400>  16

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  17
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9) CDR-L1

<400>  17

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  18
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-L2

<400>  18

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC564)  CDR-L2

<400>  19

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9) CDR-L2

<400>  20

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  21
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  CDR-L3

<400>  21

Gln Gln Tyr Leu Thr Tyr Ser Arg Phe Thr 
1               5                   10  


<210>  22
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  CDR-L3

<400>  22

Gln Gln Tyr Ser Ser Gln Pro Tyr Thr 
1               5                   


<210>  23
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  CDR-L3

<400>  23

Gln Gln Tyr Ile Ser Tyr Ser Met Leu Thr 
1               5                   10  


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  CDR-L3

<400>  24

Gln Gln Tyr Gln Ala Phe Ser Leu Thr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC-164)  CDR-L3

<400>  25

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  26
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9) CDR-L3

<400>  26

Asn Ser Arg Val Met Pro His Asn Arg Val 
1               5                   10  


<210>  27
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  VH

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Trp Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  28
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  VL

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Thr Tyr Ser Arg 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  29
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  VH

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  30
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  VL

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  31
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  VH

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Ser Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  32
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  VL

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser Tyr Ser Met 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  33
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  VH

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asn Tyr Pro Tyr Ser Tyr Trp Gly Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  34
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  VL

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Ala Phe Ser Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563)  VH

<400>  35

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Val Gly Ala Phe Asp Tyr Trp Gly Gln Gly Ala Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  36
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563)  VL

<400>  36

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  37
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-564)  VH

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Asp Val Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  38
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-564)  VL

<400>  38

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  39
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9)  VH

<400>  39

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Phe Tyr Arg Gly Gly Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  40
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9)  VL

<400>  40

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Val Met Pro His Asn Arg 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105     


<210>  41
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln 
            


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(12B3,11D5, 9B11, 20G2)  CDR-H1

<400>  42

Ser Tyr Ala Ile Ser 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(25G7)  CDR-H1

<400>  43

Ser Tyr Ala Met Ser 
1               5   


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(12B3,11D5, 9B11, 20G2)  CDR-H2

<400>  44

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(25G7)  CDR-H2

<400>  45

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(12B3)  CDR-H3

<400>  46

Ser Glu Phe Arg Phe Tyr Ala Asp Phe Asp Tyr 
1               5                   10      


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(25G7)  CDR-H3

<400>  47

Asp Asp Pro Trp Pro Pro Phe Asp Tyr 
1               5                   


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(11D5)  CDR-H3

<400>  48

Ser Thr Leu Ile Tyr Gly Tyr Phe Asp Tyr 
1               5                   10  


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(9B11)  CDR-H3

<400>  49

Ser Ser Gly Ala Tyr Pro Gly Tyr Phe Asp Tyr 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(20G2)  CDR-H3

<400>  50

Ser Tyr Tyr Trp Glu Ser Tyr Pro Phe Asp Tyr 
1               5                   10      


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(12B3,11D5, 9B11, 20G2)  CDR-L1

<400>  51

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(25G7)  CDR-L1

<400>  52

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(12B3,11D5, 9B11, 20G2)  CDR-L2

<400>  53

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(25G7)  CDR-L2

<400>  54

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(12B3)  CDR-L3

<400>  55

Gln Gln Tyr His Ser Tyr Pro Gln Thr 
1               5                   


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(25G7)  CDR-L3

<400>  56

Asn Ser Leu Asp Arg Arg Gly Met Trp Val 
1               5                   10  


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(11D5)  CDR-L3

<400>  57

Gln Gln Leu Asn Ser Tyr Pro Gln Thr 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(9B11)  CDR-L3

<400>  58

Gln Gln Val Asn Ser Tyr Pro Gln Thr 
1               5                   


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(20G2)  CDR-L3

<400>  59

Gln Gln Gln His Ser Tyr Tyr Thr 
1               5               


<210>  60
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(12B3)  VH

<400>  60

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Phe Arg Phe Tyr Ala Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(12B3)  VL

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  62
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(25G7)  VH

<400>  62

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Pro Trp Pro Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  63
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(25G7)  VL

<400>  63

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Leu Asp Arg Arg Gly Met Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105     


<210>  64
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(11D5)  VH

<400>  64

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Leu Ile Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(11D5)  VL

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  66
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(9B11)  VH

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Gly Ala Tyr Pro Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  67
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(9B11)  VL

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asn Ser Tyr Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  68
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(20G2)  VH

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Trp Glu Ser Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  69
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB(20G2)  VL

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gln His Ser Tyr Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(28H1)  CDR-H1

<400>  70

Ser His Ala Met Ser 
1               5   


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(28H1)  CDR-H2

<400>  71

Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(28H1)  CDR-H3

<400>  72

Gly Trp Leu Gly Asn Phe Asp Tyr 
1               5               


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(28H1)  CDR-L1

<400>  73

Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu Ala 
1               5                   10          


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(28H1)  CDR-L2

<400>  74

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(28H1)  CDR-L3

<400>  75

Gln Gln Gly Gln Val Ile Pro Pro Thr 
1               5                   


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-H1

<400>  76

Ser Tyr Ala Met Ser 
1               5   


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-H2

<400>  77

Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-H3

<400>  78

Gly Trp Phe Gly Gly Phe Asn Tyr 
1               5               


<210>  79
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-L1

<400>  79

Arg Ala Ser Gln Ser Val Thr Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-L2

<400>  80

Val Gly Ser Arg Arg Ala Thr 
1               5           


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-L3

<400>  81

Gln Gln Gly Ile Met Leu Pro Pro Thr 
1               5                   


<210>  82
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(28H1) VH

<400>  82

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  83
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(28H1) VL

<400>  83

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  84
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9) VH

<400>  84

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  85
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9) VL

<400>  85

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  86
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  87
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu FAP ectodomain+poly-lys-tag+his6-tag

<400>  87

Arg Pro Ser Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp Asn 
        35                  40                  45              


Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu 
    50                  55                  60                  


Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn 
145                 150                 155                 160 


Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe Ile 
225                 230                 235                 240 


Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val 
                245                 250                 255     


Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp 
    290                 295                 300                 


Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala 
        515                 520                 525             


Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr Thr 
705                 710                 715                 720 


His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly Lys 
                725                 730                 735     


Lys Lys Lys Lys Lys Gly His His His His His His 
            740                 745             


<210>  88
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu FAP ectodomain+poly-lys-tag+his6-tag

<400>  88
cgcccttcaa gagttcataa ctctgaagaa aatacaatga gagcactcac actgaaggat       60

attttaaatg gaacattttc ttataaaaca ttttttccaa actggatttc aggacaagaa      120

tatcttcatc aatctgcaga taacaatata gtactttata atattgaaac aggacaatca      180

tataccattt tgagtaatag aaccatgaaa agtgtgaatg cttcaaatta cggcttatca      240

cctgatcggc aatttgtata tctagaaagt gattattcaa agctttggag atactcttac      300

acagcaacat attacatcta tgaccttagc aatggagaat ttgtaagagg aaatgagctt      360

cctcgtccaa ttcagtattt atgctggtcg cctgttggga gtaaattagc atatgtctat      420

caaaacaata tctatttgaa acaaagacca ggagatccac cttttcaaat aacatttaat      480

ggaagagaaa ataaaatatt taatggaatc ccagactggg tttatgaaga ggaaatgctt      540

gctacaaaat atgctctctg gtggtctcct aatggaaaat ttttggcata tgcggaattt      600

aatgatacgg atataccagt tattgcctat tcctattatg gcgatgaaca atatcctaga      660

acaataaata ttccataccc aaaggctgga gctaagaatc ccgttgttcg gatatttatt      720

atcgatacca cttaccctgc gtatgtaggt ccccaggaag tgcctgttcc agcaatgata      780

gcctcaagtg attattattt cagttggctc acgtgggtta ctgatgaacg agtatgtttg      840

cagtggctaa aaagagtcca gaatgtttcg gtcctgtcta tatgtgactt cagggaagac      900

tggcagacat gggattgtcc aaagacccag gagcatatag aagaaagcag aactggatgg      960

gctggtggat tctttgtttc aacaccagtt ttcagctatg atgccatttc gtactacaaa     1020

atatttagtg acaaggatgg ctacaaacat attcactata tcaaagacac tgtggaaaat     1080

gctattcaaa ttacaagtgg caagtgggag gccataaata tattcagagt aacacaggat     1140

tcactgtttt attctagcaa tgaatttgaa gaataccctg gaagaagaaa catctacaga     1200

attagcattg gaagctatcc tccaagcaag aagtgtgtta cttgccatct aaggaaagaa     1260

aggtgccaat attacacagc aagtttcagc gactacgcca agtactatgc acttgtctgc     1320

tacggcccag gcatccccat ttccaccctt catgatggac gcactgatca agaaattaaa     1380

atcctggaag aaaacaagga attggaaaat gctttgaaaa atatccagct gcctaaagag     1440

gaaattaaga aacttgaagt agatgaaatt actttatggt acaagatgat tcttcctcct     1500

caatttgaca gatcaaagaa gtatcccttg ctaattcaag tgtatggtgg tccctgcagt     1560

cagagtgtaa ggtctgtatt tgctgttaat tggatatctt atcttgcaag taaggaaggg     1620

atggtcattg ccttggtgga tggtcgagga acagctttcc aaggtgacaa actcctctat     1680

gcagtgtatc gaaagctggg tgtttatgaa gttgaagacc agattacagc tgtcagaaaa     1740

ttcatagaaa tgggtttcat tgatgaaaaa agaatagcca tatggggctg gtcctatgga     1800

ggatacgttt catcactggc ccttgcatct ggaactggtc ttttcaaatg tggtatagca     1860

gtggctccag tctccagctg ggaatattac gcgtctgtct acacagagag attcatgggt     1920

ctcccaacaa aggatgataa tcttgagcac tataagaatt caactgtgat ggcaagagca     1980

gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac     2040

tttcaaaact cagcacagat tgctaaagct ctggttaatg cacaagtgga tttccaggca     2100

atgtggtact ctgaccagaa ccacggctta tccggcctgt ccacgaacca cttatacacc     2160

cacatgaccc acttcctaaa gcagtgtttc tctttgtcag acggcaaaaa gaaaaagaaa     2220

aagggccacc accatcacca tcac                                            2244


<210>  89
<211>  761
<212>  PRT
<213>  Mus musculus

<400>  89

Met Lys Thr Trp Leu Lys Thr Val Phe Gly Val Thr Thr Leu Ala Ala 
1               5                   10                  15      


Leu Ala Leu Val Val Ile Cys Ile Val Leu Arg Pro Ser Arg Val Tyr 
            20                  25                  30          


Lys Pro Glu Gly Asn Thr Lys Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Tyr Phe Pro Asn Trp Ile Ser Glu 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Glu Asp Asp Asn Ile Val Phe Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Arg Glu Ser Tyr Ile Ile Leu Ser Asn Ser Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Thr Asp Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Gln Asn Gly Glu Phe Val Arg Gly Tyr 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Tyr Thr Gly Arg Glu Asn Arg Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asp Gly Lys Phe Leu Ala Tyr Val 
    210                 215                 220                 


Glu Phe Asn Asp Ser Asp Ile Pro Ile Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Gly Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Val Phe Ile Val Asp Thr Thr Tyr Pro 
            260                 265                 270         


His His Val Gly Pro Met Glu Val Pro Val Pro Glu Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Ser Ser Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp His Ala Trp Glu Cys Pro Lys Asn Gln 
                325                 330                 335     


Glu His Val Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Ala Phe Ser Gln Asp Ala Thr Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Tyr Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Gly Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Asn Ser 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Tyr Lys Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Leu Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Gln Val Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ser Leu Arg Asn Ile Gln Leu Pro Lys Val Glu Ile Lys Lys Leu Lys 
            500                 505                 510         


Asp Gly Gly Leu Thr Phe Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Lys Ser Val Phe Ala Val Asn Trp Ile Thr Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Ile Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Phe Leu His Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Leu Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Glu Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Ile Tyr Ser Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Ile 
                725                 730                 735     


Ser Ser Gly Arg Ser Gln Asn His Leu Tyr Thr His Met Thr His Phe 
            740                 745                 750         


Leu Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760     


<210>  90
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Murine FAP ectodomain+poly-lys-tag+his6-tag

<400>  90

Arg Pro Ser Arg Val Tyr Lys Pro Glu Gly Asn Thr Lys Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Tyr Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Glu Gln Glu Tyr Leu His Gln Ser Glu Asp Asp 
        35                  40                  45              


Asn Ile Val Phe Tyr Asn Ile Glu Thr Arg Glu Ser Tyr Ile Ile Leu 
    50                  55                  60                  


Ser Asn Ser Thr Met Lys Ser Val Asn Ala Thr Asp Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Gln Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Gly Tyr Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Tyr Thr 
145                 150                 155                 160 


Gly Arg Glu Asn Arg Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asp Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Val Glu Phe Asn Asp Ser Asp Ile Pro Ile Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Gly Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Val Phe Ile 
225                 230                 235                 240 


Val Asp Thr Thr Tyr Pro His His Val Gly Pro Met Glu Val Pro Val 
                245                 250                 255     


Pro Glu Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Ser Ser Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp His Ala Trp 
    290                 295                 300                 


Glu Cys Pro Lys Asn Gln Glu His Val Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Ala Phe Ser Gln Asp Ala Thr 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Tyr Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Gly Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Asn Ser Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Tyr Lys 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Leu Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Gln Val Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ser Leu Arg Asn Ile Gln Leu Pro Lys Val 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Lys Asp Gly Gly Leu Thr Phe Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Lys Ser Val Phe Ala 
        515                 520                 525             


Val Asn Trp Ile Thr Tyr Leu Ala Ser Lys Glu Gly Ile Val Ile Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Phe Leu His 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Leu Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Glu Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Ile Tyr Ser Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Ile Leu Ser Gly Arg Ser Gln Asn His Leu Tyr 
705                 710                 715                 720 


Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly 
                725                 730                 735     


Lys Lys Lys Lys Lys Lys Gly His His His His His His 
            740                 745                 


<210>  91
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine FAP ectodomain+poly-lys-tag+his6-tag

<400>  91
cgtccctcaa gagtttacaa acctgaagga aacacaaaga gagctcttac cttgaaggat       60

attttaaatg gaacattctc atataaaaca tattttccca actggatttc agaacaagaa      120

tatcttcatc aatctgagga tgataacata gtattttata atattgaaac aagagaatca      180

tatatcattt tgagtaatag caccatgaaa agtgtgaatg ctacagatta tggtttgtca      240

cctgatcggc aatttgtgta tctagaaagt gattattcaa agctctggcg atattcatac      300

acagcgacat actacatcta cgaccttcag aatggggaat ttgtaagagg atacgagctc      360

cctcgtccaa ttcagtatct atgctggtcg cctgttggga gtaaattagc atatgtatat      420

caaaacaata tttatttgaa acaaagacca ggagatccac cttttcaaat aacttatact      480

ggaagagaaa atagaatatt taatggaata ccagactggg tttatgaaga ggaaatgctt      540

gccacaaaat atgctctttg gtggtctcca gatggaaaat ttttggcata tgtagaattt      600

aatgattcag atataccaat tattgcctat tcttattatg gtgatggaca gtatcctaga      660

actataaata ttccatatcc aaaggctggg gctaagaatc cggttgttcg tgtttttatt      720

gttgacacca cctaccctca ccacgtgggc ccaatggaag tgccagttcc agaaatgata      780

gcctcaagtg actattattt cagctggctc acatgggtgt ccagtgaacg agtatgcttg      840

cagtggctaa aaagagtgca gaatgtctca gtcctgtcta tatgtgattt cagggaagac      900

tggcatgcat gggaatgtcc aaagaaccag gagcatgtag aagaaagcag aacaggatgg      960

gctggtggat tctttgtttc gacaccagct tttagccagg atgccacttc ttactacaaa     1020

atatttagcg acaaggatgg ttacaaacat attcactaca tcaaagacac tgtggaaaat     1080

gctattcaaa ttacaagtgg caagtgggag gccatatata tattccgcgt aacacaggat     1140

tcactgtttt attctagcaa tgaatttgaa ggttaccctg gaagaagaaa catctacaga     1200

attagcattg gaaactctcc tccgagcaag aagtgtgtta cttgccatct aaggaaagaa     1260

aggtgccaat attacacagc aagtttcagc tacaaagcca agtactatgc actcgtctgc     1320

tatggccctg gcctccccat ttccaccctc catgatggcc gcacagacca agaaatacaa     1380

gtattagaag aaaacaaaga actggaaaat tctctgagaa atatccagct gcctaaagtg     1440

gagattaaga agctcaaaga cgggggactg actttctggt acaagatgat tctgcctcct     1500

cagtttgaca gatcaaagaa gtaccctttg ctaattcaag tgtatggtgg tccttgtagc     1560

cagagtgtta agtctgtgtt tgctgttaat tggataactt atctcgcaag taaggagggg     1620

atagtcattg ccctggtaga tggtcggggc actgctttcc aaggtgacaa attcctgcat     1680

gccgtgtatc gaaaactggg tgtatatgaa gttgaggacc agctcacagc tgtcagaaaa     1740

ttcatagaaa tgggtttcat tgatgaagaa agaatagcca tatggggctg gtcctacgga     1800

ggttatgttt catccctggc ccttgcatct ggaactggtc ttttcaaatg tggcatagca     1860

gtggctccag tctccagctg ggaatattac gcatctatct actcagagag attcatgggc     1920

ctcccaacaa aggacgacaa tctcgaacac tataaaaatt caactgtgat ggcaagagca     1980

gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac     2040

tttcagaact cagcacagat tgctaaagct ttggttaatg cacaagtgga tttccaggcg     2100

atgtggtact ctgaccagaa ccatggtata ttatctgggc gctcccagaa tcatttatat     2160

acccacatga cgcacttcct caagcaatgc ttttctttat cagacggcaa aaagaaaaag     2220

aaaaagggcc accaccatca ccatcac                                         2247


<210>  92
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cynomolgus FAP ectodomain+poly-lys-tag+his6-tag

<400>  92

Arg Pro Pro Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp Asn 
        35                  40                  45              


Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu 
    50                  55                  60                  


Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn 
145                 150                 155                 160 


Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Phe Val Arg Ile Phe Ile 
225                 230                 235                 240 


Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val 
                245                 250                 255     


Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp 
    290                 295                 300                 


Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Asp Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala 
        515                 520                 525             


Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr Thr 
705                 710                 715                 720 


His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly Lys 
                725                 730                 735     


Lys Lys Lys Lys Lys Gly His His His His His His 
            740                 745             


<210>  93
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cynomolgus FAP ectodomain+poly-lys-tag+his6-tag

<400>  93
cgccctccaa gagttcataa ctctgaagaa aatacaatga gagcactcac actgaaggat       60

attttaaatg ggacattttc ttataaaaca ttttttccaa actggatttc aggacaagaa      120

tatcttcatc aatctgcaga taacaatata gtactttata atattgaaac aggacaatca      180

tataccattt tgagtaacag aaccatgaaa agtgtgaatg cttcaaatta tggcttatca      240

cctgatcggc aatttgtata tctagaaagt gattattcaa agctttggag atactcttac      300

acagcaacat attacatcta tgaccttagc aatggagaat ttgtaagagg aaatgagctt      360

cctcgtccaa ttcagtattt atgctggtcg cctgttggga gtaaattagc atatgtctat      420

caaaacaata tctatttgaa acaaagacca ggagatccac cttttcaaat aacatttaat      480

ggaagagaaa ataaaatatt taatggaatc ccagactggg tttatgaaga ggaaatgctt      540

gctacaaaat atgctctctg gtggtctcct aatggaaaat ttttggcata tgcggaattt      600

aatgatacag atataccagt tattgcctat tcctattatg gcgatgaaca atatcccaga      660

acaataaata ttccataccc aaaggccgga gctaagaatc cttttgttcg gatatttatt      720

atcgatacca cttaccctgc gtatgtaggt ccccaggaag tgcctgttcc agcaatgata      780

gcctcaagtg attattattt cagttggctc acgtgggtta ctgatgaacg agtatgtttg      840

cagtggctaa aaagagtcca gaatgtttcg gtcttgtcta tatgtgattt cagggaagac      900

tggcagacat gggattgtcc aaagacccag gagcatatag aagaaagcag aactggatgg      960

gctggtggat tctttgtttc aacaccagtt ttcagctatg atgccatttc atactacaaa     1020

atatttagtg acaaggatgg ctacaaacat attcactata tcaaagacac tgtggaaaat     1080

gctattcaaa ttacaagtgg caagtgggag gccataaata tattcagagt aacacaggat     1140

tcactgtttt attctagcaa tgaatttgaa gattaccctg gaagaagaaa catctacaga     1200

attagcattg gaagctatcc tccaagcaag aagtgtgtta cttgccatct aaggaaagaa     1260

aggtgccaat attacacagc aagtttcagc gactacgcca agtactatgc acttgtctgc     1320

tatggcccag gcatccccat ttccaccctt catgacggac gcactgatca agaaattaaa     1380

atcctggaag aaaacaagga attggaaaat gctttgaaaa atatccagct gcctaaagag     1440

gaaattaaga aacttgaagt agatgaaatt actttatggt acaagatgat tcttcctcct     1500

caatttgaca gatcaaagaa gtatcccttg ctaattcaag tgtatggtgg tccctgcagt     1560

cagagtgtaa ggtctgtatt tgctgttaat tggatatctt atcttgcaag taaggaaggg     1620

atggtcattg ccttggtgga tggtcgggga acagctttcc aaggtgacaa actcctgtat     1680

gcagtgtatc gaaagctggg tgtttatgaa gttgaagacc agattacagc tgtcagaaaa     1740

ttcatagaaa tgggtttcat tgatgaaaaa agaatagcca tatggggctg gtcctatgga     1800

ggatatgttt catcactggc ccttgcatct ggaactggtc ttttcaaatg tgggatagca     1860

gtggctccag tctccagctg ggaatattac gcgtctgtct acacagagag attcatgggt     1920

ctcccaacaa aggatgataa tcttgagcac tataagaatt caactgtgat ggcaagagca     1980

gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac     2040

tttcaaaact cagcacagat tgctaaagct ctggttaatg cacaagtgga tttccaggca     2100

atgtggtact ctgaccagaa ccacggctta tccggcctgt ccacgaacca cttatacacc     2160

cacatgaccc acttcctaaa gcagtgtttc tctttgtcag acggcaaaaa gaaaaagaaa     2220

aagggccacc accatcacca tcac                                            2244


<210>  94
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Lys Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  95
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  96
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  97
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  98
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  99
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  100
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  101
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  102
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  103
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  104
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  105
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  106
<211>  272
<212>  PRT
<213>  Mus musculus

<400>  106

Met Tyr Val Trp Val Gln Gln Pro Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Thr Leu Gly Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr 
            20                  25                  30          


Pro Ser Gly His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met 
        35                  40                  45              


Val Ser Arg Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu 
    50                  55                  60                  


Thr Gly Phe Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys 
65                  70                  75                  80  


Thr Gln Cys Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr 
                85                  90                  95      


Pro Thr Gln Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg 
            100                 105                 110         


Gln Asp Ser Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro 
        115                 120                 125             


Gly His Phe Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn 
    130                 135                 140                 


Cys Thr Leu Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu 
145                 150                 155                 160 


Asp Ala Val Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu 
                165                 170                 175     


Thr Gln Arg Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val 
            180                 185                 190         


Trp Pro Arg Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro 
        195                 200                 205             


Glu Gly Pro Ala Phe Ala Val Leu Leu Gly Leu Gly Leu Gly Leu Leu 
    210                 215                 220                 


Ala Pro Leu Thr Val Leu Leu Ala Leu Tyr Leu Leu Arg Lys Ala Trp 
225                 230                 235                 240 


Arg Leu Pro Asn Thr Pro Lys Pro Cys Trp Gly Asn Ser Phe Arg Thr 
                245                 250                 255     


Pro Ile Gln Glu Glu His Thr Asp Ala His Phe Thr Leu Ala Lys Ile 
            260                 265                 270         


<210>  107
<211>  256
<212>  PRT
<213>  Mus musculus

<400>  107

Met Gly Asn Asn Cys Tyr Asn Val Val Val Ile Val Leu Leu Leu Val 
1               5                   10                  15      


Gly Cys Glu Lys Val Gly Ala Val Gln Asn Ser Cys Asp Asn Cys Gln 
            20                  25                  30          


Pro Gly Thr Phe Cys Arg Lys Tyr Asn Pro Val Cys Lys Ser Cys Pro 
        35                  40                  45              


Pro Ser Thr Phe Ser Ser Ile Gly Gly Gln Pro Asn Cys Asn Ile Cys 
    50                  55                  60                  


Arg Val Cys Ala Gly Tyr Phe Arg Phe Lys Lys Phe Cys Ser Ser Thr 
65                  70                  75                  80  


His Asn Ala Glu Cys Glu Cys Ile Glu Gly Phe His Cys Leu Gly Pro 
                85                  90                  95      


Gln Cys Thr Arg Cys Glu Lys Asp Cys Arg Pro Gly Gln Glu Leu Thr 
            100                 105                 110         


Lys Gln Gly Cys Lys Thr Cys Ser Leu Gly Thr Phe Asn Asp Gln Asn 
        115                 120                 125             


Gly Thr Gly Val Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Arg 
    130                 135                 140                 


Ser Val Leu Lys Thr Gly Thr Thr Glu Lys Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Pro Val Val Ser Phe Ser Pro Ser Thr Thr Ile Ser Val Thr Pro Glu 
                165                 170                 175     


Gly Gly Pro Gly Gly His Ser Leu Gln Val Leu Thr Leu Phe Leu Ala 
            180                 185                 190         


Leu Thr Ser Ala Leu Leu Leu Ala Leu Ile Phe Ile Thr Leu Leu Phe 
        195                 200                 205             


Ser Val Leu Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
    210                 215                 220                 


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
225                 230                 235                 240 


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
                245                 250                 255     


<210>  108
<211>  254
<212>  PRT
<213>  Macaca fascicularis

<400>  108

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Leu Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Ser Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Lys Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Ile Ser Gly Tyr His Cys Leu Gly 
                85                  90                  95      


Ala Glu Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Ala Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Phe Phe Leu Ala 
            180                 185                 190         


Leu Thr Ser Thr Val Val Leu Phe Leu Leu Phe Phe Leu Val Leu Arg 
        195                 200                 205             


Phe Ser Val Val Lys Arg Ser Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 


<210>  109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Petpide linker G4S

<400>  109

Gly Gly Gly Gly Ser 
1               5   


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (G4S)2

<400>  110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (SG4)2

<400>  111

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210>  112
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (G4S)3

<400>  112

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  113
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker G4(SG4)2

<400>  113

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  114
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (G4S)4

<400>  114

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GSPGSSSSGS

<400>  115

Gly Ser Pro Gly Ser Ser Ser Ser Gly Ser 
1               5                   10  


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GSGSGSGS

<400>  116

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GSGSGNGS

<400>  117

Gly Ser Gly Ser Gly Asn Gly Ser 
1               5               


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGSGSGSG

<400>  118

Gly Gly Ser Gly Ser Gly Ser Gly 
1               5               


<210>  119
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGSGSG

<400>  119

Gly Gly Ser Gly Ser Gly 
1               5       


<210>  120
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linkeer GGSG

<400>  120

Gly Gly Ser Gly 
1               


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGSGNGSG

<400>  121

Gly Gly Ser Gly Asn Gly Ser Gly 
1               5               


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGNGSGSG

<400>  122

Gly Gly Asn Gly Ser Gly Ser Gly 
1               5               


<210>  123
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGNGSG

<400>  123

Gly Gly Asn Gly Ser Gly 
1               5       


<210>  124
<211>  501
<212>  PRT
<213>  human

<400>  124

Met Ala Ala Ala Ser Val Thr Pro Pro Gly Ser Leu Glu Leu Leu Gln 
1               5                   10                  15      


Pro Gly Phe Ser Lys Thr Leu Leu Gly Thr Lys Leu Glu Ala Lys Tyr 
            20                  25                  30          


Leu Cys Ser Ala Cys Arg Asn Val Leu Arg Arg Pro Phe Gln Ala Gln 
        35                  40                  45              


Cys Gly His Arg Tyr Cys Ser Phe Cys Leu Ala Ser Ile Leu Ser Ser 
    50                  55                  60                  


Gly Pro Gln Asn Cys Ala Ala Cys Val His Glu Gly Ile Tyr Glu Glu 
65                  70                  75                  80  


Gly Ile Ser Ile Leu Glu Ser Ser Ser Ala Phe Pro Asp Asn Ala Ala 
                85                  90                  95      


Arg Arg Glu Val Glu Ser Leu Pro Ala Val Cys Pro Ser Asp Gly Cys 
            100                 105                 110         


Thr Trp Lys Gly Thr Leu Lys Glu Tyr Glu Ser Cys His Glu Gly Arg 
        115                 120                 125             


Cys Pro Leu Met Leu Thr Glu Cys Pro Ala Cys Lys Gly Leu Val Arg 
    130                 135                 140                 


Leu Gly Glu Lys Glu Arg His Leu Glu His Glu Cys Pro Glu Arg Ser 
145                 150                 155                 160 


Leu Ser Cys Arg His Cys Arg Ala Pro Cys Cys Gly Ala Asp Val Lys 
                165                 170                 175     


Ala His His Glu Val Cys Pro Lys Phe Pro Leu Thr Cys Asp Gly Cys 
            180                 185                 190         


Gly Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln Asp His Val Lys Thr 
        195                 200                 205             


Cys Gly Lys Cys Arg Val Pro Cys Arg Phe His Ala Ile Gly Cys Leu 
    210                 215                 220                 


Glu Thr Val Glu Gly Glu Lys Gln Gln Glu His Glu Val Gln Trp Leu 
225                 230                 235                 240 


Arg Glu His Leu Ala Met Leu Leu Ser Ser Val Leu Glu Ala Lys Pro 
                245                 250                 255     


Leu Leu Gly Asp Gln Ser His Ala Gly Ser Glu Leu Leu Gln Arg Cys 
            260                 265                 270         


Glu Ser Leu Glu Lys Lys Thr Ala Thr Phe Glu Asn Ile Val Cys Val 
        275                 280                 285             


Leu Asn Arg Glu Val Glu Arg Val Ala Met Thr Ala Glu Ala Cys Ser 
    290                 295                 300                 


Arg Gln His Arg Leu Asp Gln Asp Lys Ile Glu Ala Leu Ser Ser Lys 
305                 310                 315                 320 


Val Gln Gln Leu Glu Arg Ser Ile Gly Leu Lys Asp Leu Ala Met Ala 
                325                 330                 335     


Asp Leu Glu Gln Lys Val Leu Glu Met Glu Ala Ser Thr Tyr Asp Gly 
            340                 345                 350         


Val Phe Ile Trp Lys Ile Ser Asp Phe Ala Arg Lys Arg Gln Glu Ala 
        355                 360                 365             


Val Ala Gly Arg Ile Pro Ala Ile Phe Ser Pro Ala Phe Tyr Thr Ser 
    370                 375                 380                 


Arg Tyr Gly Tyr Lys Met Cys Leu Arg Ile Tyr Leu Asn Gly Asp Gly 
385                 390                 395                 400 


Thr Gly Arg Gly Thr His Leu Ser Leu Phe Phe Val Val Met Lys Gly 
                405                 410                 415     


Pro Asn Asp Ala Leu Leu Arg Trp Pro Phe Asn Gln Lys Val Thr Leu 
            420                 425                 430         


Met Leu Leu Asp Gln Asn Asn Arg Glu His Val Ile Asp Ala Phe Arg 
        435                 440                 445             


Pro Asp Val Thr Ser Ser Ser Phe Gln Arg Pro Val Asn Asp Met Asn 
    450                 455                 460                 


Ile Ala Ser Gly Cys Pro Leu Phe Cys Pro Val Ser Lys Met Glu Ala 
465                 470                 475                 480 


Lys Asn Ser Tyr Val Arg Asp Asp Ala Ile Phe Ile Lys Ala Ile Val 
                485                 490                 495     


Asp Leu Thr Gly Leu 
            500     


<210>  125
<211>  1170
<212>  PRT
<213>  human

<400>  125

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  126
<211>  622
<212>  PRT
<213>  human

<400>  126

Met Arg Gly Leu Leu Cys Trp Pro Val Leu Leu Leu Leu Leu Gln Pro 
1               5                   10                  15      


Trp Glu Thr Gln Leu Gln Leu Thr Gly Pro Arg Cys His Thr Gly Pro 
            20                  25                  30          


Leu Asp Leu Val Phe Val Ile Asp Ser Ser Arg Ser Val Arg Pro Phe 
        35                  40                  45              


Glu Phe Glu Thr Met Arg Gln Phe Leu Met Gly Leu Leu Arg Gly Leu 
    50                  55                  60                  


Asn Val Gly Pro Asn Ala Thr Arg Val Gly Val Ile Gln Tyr Ser Ser 
65                  70                  75                  80  


Gln Val Gln Ser Val Phe Pro Leu Arg Ala Phe Ser Arg Arg Glu Asp 
                85                  90                  95      


Met Glu Arg Ala Ile Arg Asp Leu Val Pro Leu Ala Gln Gly Thr Met 
            100                 105                 110         


Thr Gly Leu Ala Ile Gln Tyr Ala Met Asn Val Ala Phe Ser Val Ala 
        115                 120                 125             


Glu Gly Ala Arg Pro Pro Glu Glu Arg Val Pro Arg Val Ala Val Ile 
    130                 135                 140                 


Val Thr Asp Gly Arg Pro Gln Asp Arg Val Ala Glu Val Ala Ala Gln 
145                 150                 155                 160 


Ala Arg Ala Arg Gly Ile Glu Ile Tyr Ala Val Gly Val Gln Arg Ala 
                165                 170                 175     


Asp Val Gly Ser Leu Arg Ala Met Ala Ser Pro Pro Leu Asp Glu His 
            180                 185                 190         


Val Phe Leu Val Glu Ser Phe Asp Leu Ile Gln Glu Phe Gly Leu Gln 
        195                 200                 205             


Phe Gln Ser Arg Leu Cys Gly Lys Asp Gln Cys Ala Glu Gly Gly His 
    210                 215                 220                 


Gly Cys Gln His Gln Cys Val Asn Ala Trp Ala Met Phe His Cys Thr 
225                 230                 235                 240 


Cys Asn Pro Gly Tyr Lys Leu Ala Ala Asp Asn Lys Ser Cys Leu Ala 
                245                 250                 255     


Ile Asp Leu Cys Ala Glu Gly Thr His Gly Cys Glu His His Cys Val 
            260                 265                 270         


Asn Ser Pro Gly Ser Tyr Phe Cys His Cys Gln Val Gly Phe Val Leu 
        275                 280                 285             


Gln Gln Asp Gln Arg Ser Cys Arg Ala Ile Asp Tyr Cys Ser Phe Gly 
    290                 295                 300                 


Asn His Ser Cys Gln His Glu Cys Val Ser Thr Pro Gly Gly Pro Arg 
305                 310                 315                 320 


Cys His Cys Arg Glu Gly His Asp Leu Gln Pro Asp Gly Arg Ser Cys 
                325                 330                 335     


Gln Val Arg Asp Leu Cys Asn Gly Val Asp His Gly Cys Glu Phe Gln 
            340                 345                 350         


Cys Val Ser Glu Gly Leu Ser Tyr Arg Cys Leu Cys Pro Glu Gly Arg 
        355                 360                 365             


Gln Leu Gln Ala Asp Gly Lys Ser Cys Asn Arg Cys Arg Glu Gly His 
    370                 375                 380                 


Val Asp Leu Val Leu Leu Val Asp Gly Ser Lys Ser Val Arg Pro Gln 
385                 390                 395                 400 


Asn Phe Glu Leu Val Lys Arg Phe Val Asn Gln Ile Val Asp Phe Leu 
                405                 410                 415     


Asp Val Ser Pro Glu Gly Thr Arg Val Gly Leu Val Gln Phe Ser Ser 
            420                 425                 430         


Arg Val Arg Thr Glu Phe Pro Leu Gly Arg Tyr Gly Thr Ala Ala Glu 
        435                 440                 445             


Val Lys Gln Ala Val Leu Ala Val Glu Tyr Met Glu Arg Gly Thr Met 
    450                 455                 460                 


Thr Gly Leu Ala Leu Arg His Met Val Glu His Ser Phe Ser Glu Ala 
465                 470                 475                 480 


Gln Gly Ala Arg Pro Arg Ala Leu Asn Val Pro Arg Val Gly Leu Val 
                485                 490                 495     


Phe Thr Asp Gly Arg Ser Gln Asp Asp Ile Ser Val Trp Ala Ala Arg 
            500                 505                 510         


Ala Lys Glu Glu Gly Ile Val Met Tyr Ala Val Gly Val Gly Lys Ala 
        515                 520                 525             


Val Glu Ala Glu Leu Arg Glu Ile Ala Ser Glu Pro Ala Glu Leu His 
    530                 535                 540                 


Val Ser Tyr Ala Pro Asp Phe Gly Thr Met Thr His Leu Leu Glu Asn 
545                 550                 555                 560 


Leu Arg Gly Ser Ile Cys Pro Glu Glu Gly Ile Ser Ala Gly Thr Glu 
                565                 570                 575     


Leu Arg Ser Pro Cys Glu Cys Glu Ser Leu Val Glu Phe Gln Gly Arg 
            580                 585                 590         


Thr Leu Gly Ala Leu Glu Ser Leu Thr Leu Asn Leu Ala Gln Leu Thr 
        595                 600                 605             


Ala Arg Leu Glu Asp Leu Glu Asn Gln Leu Ala Asn Gln Lys 
    610                 615                 620         


<210>  127
<211>  3623
<212>  PRT
<213>  human

<400>  127

Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ile Phe Ala Glu Val Asn Gly Glu Ala Gly Glu Leu Glu Leu Gln Arg 
            20                  25                  30          


Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg 
        35                  40                  45              


Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg 
    50                  55                  60                  


Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu 
65                  70                  75                  80  


Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys 
                85                  90                  95      


Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln 
            100                 105                 110         


Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln 
        115                 120                 125             


Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly 
    130                 135                 140                 


Gly Thr Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro 
145                 150                 155                 160 


Gln Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile 
                165                 170                 175     


Tyr Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn 
            180                 185                 190         


Thr Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro 
        195                 200                 205             


Gln Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg 
    210                 215                 220                 


Cys Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu 
225                 230                 235                 240 


Pro Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Phe Ser Pro Asn 
                245                 250                 255     


Ser Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly 
            260                 265                 270         


Pro Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr 
        275                 280                 285             


Cys Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu 
    290                 295                 300                 


Asp Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro 
305                 310                 315                 320 


Pro Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys 
                325                 330                 335     


Pro Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile 
            340                 345                 350         


Cys Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser 
        355                 360                 365             


Thr Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly 
    370                 375                 380                 


Asn Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu 
385                 390                 395                 400 


Ser His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr 
                405                 410                 415     


Phe Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn 
            420                 425                 430         


Ile Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val 
        435                 440                 445             


Asp Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly 
    450                 455                 460                 


Ala Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly 
465                 470                 475                 480 


Ile Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His 
                485                 490                 495     


Asp Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu 
            500                 505                 510         


Arg Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro 
        515                 520                 525             


His Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln 
    530                 535                 540                 


Leu Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser 
545                 550                 555                 560 


Asp Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly 
                565                 570                 575     


Arg Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly 
            580                 585                 590         


Ile Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly 
        595                 600                 605             


Asn Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro 
    610                 615                 620                 


Asp Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His 
625                 630                 635                 640 


Asp Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr 
                645                 650                 655     


Gln Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro 
            660                 665                 670         


Leu Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser 
        675                 680                 685             


Gln Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser 
    690                 695                 700                 


Asp Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe 
705                 710                 715                 720 


Leu Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr 
                725                 730                 735     


Met Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His 
            740                 745                 750         


Val Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val 
        755                 760                 765             


Arg Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile 
    770                 775                 780                 


Ser His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile 
785                 790                 795                 800 


Asp Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala 
                805                 810                 815     


Cys Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe 
            820                 825                 830         


Pro Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln 
        835                 840                 845             


Pro Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly 
    850                 855                 860                 


Ser Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser 
865                 870                 875                 880 


Ile Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro 
                885                 890                 895     


Ser Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys 
            900                 905                 910         


Ser Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu 
        915                 920                 925             


Asp Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln 
    930                 935                 940                 


Ser Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp 
945                 950                 955                 960 


His Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr 
                965                 970                 975     


Phe His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val 
            980                 985                 990         


Tyr Asp Thr Asp Ser Glu Thr Ser  Leu Gly Arg Tyr Cys  Gly Lys Ser 
        995                 1000                 1005             


Ile Pro  Pro Ser Leu Thr Ser  Ser Gly Asn Ser Leu  Met Leu Val 
    1010                 1015                 1020             


Phe Val  Thr Asp Ser Asp Leu  Ala Tyr Glu Gly Phe  Leu Ile Asn 
    1025                 1030                 1035             


Tyr Glu  Ala Ile Ser Ala Ala  Thr Ala Cys Leu Gln  Asp Tyr Thr 
    1040                 1045                 1050             


Asp Asp  Leu Gly Thr Phe Thr  Ser Pro Asn Phe Pro  Asn Asn Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Trp Glu Cys Ile  Tyr Arg Ile Thr Val  Arg Thr Gly 
    1070                 1075                 1080             


Gln Leu  Ile Ala Val His Phe  Thr Asn Phe Ser Leu  Glu Glu Ala 
    1085                 1090                 1095             


Ile Gly  Asn Tyr Tyr Thr Asp  Phe Leu Glu Ile Arg  Asp Gly Gly 
    1100                 1105                 1110             


Tyr Glu  Lys Ser Pro Leu Leu  Gly Ile Phe Tyr Gly  Ser Asn Leu 
    1115                 1120                 1125             


Pro Pro  Thr Ile Ile Ser His  Ser Asn Lys Leu Trp  Leu Lys Phe 
    1130                 1135                 1140             


Lys Ser  Asp Gln Ile Asp Thr  Arg Ser Gly Phe Ser  Ala Tyr Trp 
    1145                 1150                 1155             


Asp Gly  Ser Ser Thr Gly Cys  Gly Gly Asn Leu Thr  Thr Ser Ser 
    1160                 1165                 1170             


Gly Thr  Phe Ile Ser Pro Asn  Tyr Pro Met Pro Tyr  Tyr His Ser 
    1175                 1180                 1185             


Ser Glu  Cys Tyr Trp Trp Leu  Lys Ser Ser His Gly  Ser Ala Phe 
    1190                 1195                 1200             


Glu Leu  Glu Phe Lys Asp Phe  His Leu Glu His His  Pro Asn Cys 
    1205                 1210                 1215             


Thr Leu  Asp Tyr Leu Ala Val  Tyr Asp Gly Pro Ser  Ser Asn Ser 
    1220                 1225                 1230             


His Leu  Leu Thr Gln Leu Cys  Gly Asp Glu Lys Pro  Pro Leu Ile 
    1235                 1240                 1245             


Arg Ser  Ser Gly Asp Ser Met  Phe Ile Lys Leu Arg  Thr Asp Glu 
    1250                 1255                 1260             


Gly Gln  Gln Gly Arg Gly Phe  Lys Ala Glu Tyr Arg  Gln Thr Cys 
    1265                 1270                 1275             


Glu Asn  Val Val Ile Val Asn  Gln Thr Tyr Gly Ile  Leu Glu Ser 
    1280                 1285                 1290             


Ile Gly  Tyr Pro Asn Pro Tyr  Ser Glu Asn Gln His  Cys Asn Trp 
    1295                 1300                 1305             


Thr Ile  Arg Ala Thr Thr Gly  Asn Thr Val Asn Tyr  Thr Phe Leu 
    1310                 1315                 1320             


Ala Phe  Asp Leu Glu His His  Ile Asn Cys Ser Thr  Asp Tyr Leu 
    1325                 1330                 1335             


Glu Leu  Tyr Asp Gly Pro Arg  Gln Met Gly Arg Tyr  Cys Gly Val 
    1340                 1345                 1350             


Asp Leu  Pro Pro Pro Gly Ser  Thr Thr Ser Ser Lys  Leu Gln Val 
    1355                 1360                 1365             


Leu Leu  Leu Thr Asp Gly Val  Gly Arg Arg Glu Lys  Gly Phe Gln 
    1370                 1375                 1380             


Met Gln  Trp Phe Val Tyr Gly  Cys Gly Gly Glu Leu  Ser Gly Ala 
    1385                 1390                 1395             


Thr Gly  Ser Phe Ser Ser Pro  Gly Phe Pro Asn Arg  Tyr Pro Pro 
    1400                 1405                 1410             


Asn Lys  Glu Cys Ile Trp Tyr  Ile Arg Thr Asp Pro  Gly Ser Ser 
    1415                 1420                 1425             


Ile Gln  Leu Thr Ile His Asp  Phe Asp Val Glu Tyr  His Ser Arg 
    1430                 1435                 1440             


Cys Asn  Phe Asp Val Leu Glu  Ile Tyr Gly Gly Pro  Asp Phe His 
    1445                 1450                 1455             


Ser Pro  Arg Ile Ala Gln Leu  Cys Thr Gln Arg Ser  Pro Glu Asn 
    1460                 1465                 1470             


Pro Met  Gln Val Ser Ser Thr  Gly Asn Glu Leu Ala  Ile Arg Phe 
    1475                 1480                 1485             


Lys Thr  Asp Leu Ser Ile Asn  Gly Arg Gly Phe Asn  Ala Ser Trp 
    1490                 1495                 1500             


Gln Ala  Val Thr Gly Gly Cys  Gly Gly Ile Phe Gln  Ala Pro Ser 
    1505                 1510                 1515             


Gly Glu  Ile His Ser Pro Asn  Tyr Pro Ser Pro Tyr  Arg Ser Asn 
    1520                 1525                 1530             


Thr Asp  Cys Ser Trp Val Ile  Arg Val Asp Arg Asn  His Arg Val 
    1535                 1540                 1545             


Leu Leu  Asn Phe Thr Asp Phe  Asp Leu Glu Pro Gln  Asp Ser Cys 
    1550                 1555                 1560             


Ile Met  Ala Tyr Asp Gly Leu  Ser Ser Thr Met Ser  Arg Leu Ala 
    1565                 1570                 1575             


Arg Thr  Cys Gly Arg Glu Gln  Leu Ala Asn Pro Ile  Val Ser Ser 
    1580                 1585                 1590             


Gly Asn  Ser Leu Phe Leu Arg  Phe Gln Ser Gly Pro  Ser Arg Gln 
    1595                 1600                 1605             


Asn Arg  Gly Phe Arg Ala Gln  Phe Arg Gln Ala Cys  Gly Gly His 
    1610                 1615                 1620             


Ile Leu  Thr Ser Ser Phe Asp  Thr Val Ser Ser Pro  Arg Phe Pro 
    1625                 1630                 1635             


Ala Asn  Tyr Pro Asn Asn Gln  Asn Cys Ser Trp Ile  Ile Gln Ala 
    1640                 1645                 1650             


Gln Pro  Pro Leu Asn His Ile  Thr Leu Ser Phe Thr  His Phe Glu 
    1655                 1660                 1665             


Leu Glu  Arg Ser Thr Thr Cys  Ala Arg Asp Phe Val  Glu Ile Leu 
    1670                 1675                 1680             


Asp Gly  Gly His Glu Asp Ala  Pro Leu Arg Gly Arg  Tyr Cys Gly 
    1685                 1690                 1695             


Thr Asp  Met Pro His Pro Ile  Thr Ser Phe Ser Ser  Ala Leu Thr 
    1700                 1705                 1710             


Leu Arg  Phe Val Ser Asp Ser  Ser Ile Ser Ala Gly  Gly Phe His 
    1715                 1720                 1725             


Thr Thr  Val Thr Ala Ser Val  Ser Ala Cys Gly Gly  Thr Phe Tyr 
    1730                 1735                 1740             


Met Ala  Glu Gly Ile Phe Asn  Ser Pro Gly Tyr Pro  Asp Ile Tyr 
    1745                 1750                 1755             


Pro Pro  Asn Val Glu Cys Val  Trp Asn Ile Val Ser  Ser Pro Gly 
    1760                 1765                 1770             


Asn Arg  Leu Gln Leu Ser Phe  Ile Ser Phe Gln Leu  Glu Asp Ser 
    1775                 1780                 1785             


Gln Asp  Cys Ser Arg Asp Phe  Val Glu Ile Arg Glu  Gly Asn Ala 
    1790                 1795                 1800             


Thr Gly  His Leu Val Gly Arg  Tyr Cys Gly Asn Ser  Phe Pro Leu 
    1805                 1810                 1815             


Asn Tyr  Ser Ser Ile Val Gly  His Thr Leu Trp Val  Arg Phe Ile 
    1820                 1825                 1830             


Ser Asp  Gly Ser Gly Ser Gly  Thr Gly Phe Gln Ala  Thr Phe Met 
    1835                 1840                 1845             


Lys Ile  Phe Gly Asn Asp Asn  Ile Val Gly Thr His  Gly Lys Val 
    1850                 1855                 1860             


Ala Ser  Pro Phe Trp Pro Glu  Asn Tyr Pro His Asn  Ser Asn Tyr 
    1865                 1870                 1875             


Gln Trp  Thr Val Asn Val Asn  Ala Ser His Val Val  His Gly Arg 
    1880                 1885                 1890             


Ile Leu  Glu Met Asp Ile Glu  Glu Ile Gln Asn Cys  Tyr Tyr Asp 
    1895                 1900                 1905             


Lys Leu  Arg Ile Tyr Asp Gly  Pro Ser Ile His Ala  Arg Leu Ile 
    1910                 1915                 1920             


Gly Ala  Tyr Cys Gly Thr Gln  Thr Glu Ser Phe Ser  Ser Thr Gly 
    1925                 1930                 1935             


Asn Ser  Leu Thr Phe His Phe  Tyr Ser Asp Ser Ser  Ile Ser Gly 
    1940                 1945                 1950             


Lys Gly  Phe Leu Leu Glu Trp  Phe Ala Val Asp Ala  Pro Asp Gly 
    1955                 1960                 1965             


Val Leu  Pro Thr Ile Ala Pro  Gly Ala Cys Gly Gly  Phe Leu Arg 
    1970                 1975                 1980             


Thr Gly  Asp Ala Pro Val Phe  Leu Phe Ser Pro Gly  Trp Pro Asp 
    1985                 1990                 1995             


Ser Tyr  Ser Asn Arg Val Asp  Cys Thr Trp Leu Ile  Gln Ala Pro 
    2000                 2005                 2010             


Asp Ser  Thr Val Glu Leu Asn  Ile Leu Ser Leu Asp  Ile Glu Ser 
    2015                 2020                 2025             


His Arg  Thr Cys Ala Tyr Asp  Ser Leu Val Ile Arg  Asp Gly Asp 
    2030                 2035                 2040             


Asn Asn  Leu Ala Gln Gln Leu  Ala Val Leu Cys Gly  Arg Glu Ile 
    2045                 2050                 2055             


Pro Gly  Pro Ile Arg Ser Thr  Gly Glu Tyr Met Phe  Ile Arg Phe 
    2060                 2065                 2070             


Thr Ser  Asp Ser Ser Val Thr  Arg Ala Gly Phe Asn  Ala Ser Phe 
    2075                 2080                 2085             


His Lys  Ser Cys Gly Gly Tyr  Leu His Ala Asp Arg  Gly Ile Ile 
    2090                 2095                 2100             


Thr Ser  Pro Lys Tyr Pro Glu  Thr Tyr Pro Ser Asn  Leu Asn Cys 
    2105                 2110                 2115             


Ser Trp  His Val Leu Val Gln  Ser Gly Leu Thr Ile  Ala Val His 
    2120                 2125                 2130             


Phe Glu  Gln Pro Phe Gln Ile  Pro Asn Gly Asp Ser  Ser Cys Asn 
    2135                 2140                 2145             


Gln Gly  Asp Tyr Leu Val Leu  Arg Asn Gly Pro Asp  Ile Cys Ser 
    2150                 2155                 2160             


Pro Pro  Leu Gly Pro Pro Gly  Gly Asn Gly His Phe  Cys Gly Ser 
    2165                 2170                 2175             


His Ala  Ser Ser Thr Leu Phe  Thr Ser Asp Asn Gln  Met Phe Val 
    2180                 2185                 2190             


Gln Phe  Ile Ser Asp His Ser  Asn Glu Gly Gln Gly  Phe Lys Ile 
    2195                 2200                 2205             


Lys Tyr  Glu Ala Lys Ser Leu  Ala Cys Gly Gly Asn  Val Tyr Ile 
    2210                 2215                 2220             


His Asp  Ala Asp Ser Ala Gly  Tyr Val Thr Ser Pro  Asn His Pro 
    2225                 2230                 2235             


His Asn  Tyr Pro Pro His Ala  Asp Cys Ile Trp Ile  Leu Ala Ala 
    2240                 2245                 2250             


Pro Pro  Glu Thr Arg Ile Gln  Leu Gln Phe Glu Asp  Arg Phe Asp 
    2255                 2260                 2265             


Ile Glu  Val Thr Pro Asn Cys  Thr Ser Asn Tyr Leu  Glu Leu Arg 
    2270                 2275                 2280             


Asp Gly  Val Asp Ser Asp Ala  Pro Ile Leu Ser Lys  Phe Cys Gly 
    2285                 2290                 2295             


Thr Ser  Leu Pro Ser Ser Gln  Trp Ser Ser Gly Glu  Val Met Tyr 
    2300                 2305                 2310             


Leu Arg  Phe Arg Ser Asp Asn  Ser Pro Thr His Val  Gly Phe Lys 
    2315                 2320                 2325             


Ala Lys  Tyr Ser Ile Ala Gln  Cys Gly Gly Arg Val  Pro Gly Gln 
    2330                 2335                 2340             


Ser Gly  Val Val Glu Ser Ile  Gly His Pro Thr Leu  Pro Tyr Arg 
    2345                 2350                 2355             


Asp Asn  Leu Phe Cys Glu Trp  His Leu Gln Gly Leu  Ser Gly His 
    2360                 2365                 2370             


Tyr Leu  Thr Ile Ser Phe Glu  Asp Phe Asn Leu Gln  Asn Ser Ser 
    2375                 2380                 2385             


Gly Cys  Glu Lys Asp Phe Val  Glu Ile Trp Asp Asn  His Thr Ser 
    2390                 2395                 2400             


Gly Asn  Ile Leu Gly Arg Tyr  Cys Gly Asn Thr Ile  Pro Asp Ser 
    2405                 2410                 2415             


Ile Asp  Thr Ser Ser Asn Thr  Ala Val Val Arg Phe  Val Thr Asp 
    2420                 2425                 2430             


Gly Ser  Val Thr Ala Ser Gly  Phe Arg Leu Arg Phe  Glu Ser Ser 
    2435                 2440                 2445             


Met Glu  Glu Cys Gly Gly Asp  Leu Gln Gly Ser Ile  Gly Thr Phe 
    2450                 2455                 2460             


Thr Ser  Pro Asn Tyr Pro Asn  Pro Asn Pro His Gly  Arg Ile Cys 
    2465                 2470                 2475             


Glu Trp  Arg Ile Thr Ala Pro  Glu Gly Arg Arg Ile  Thr Leu Met 
    2480                 2485                 2490             


Phe Asn  Asn Leu Arg Leu Ala  Thr His Pro Ser Cys  Asn Asn Glu 
    2495                 2500                 2505             


His Val  Ile Val Phe Asn Gly  Ile Arg Ser Asn Ser  Pro Gln Leu 
    2510                 2515                 2520             


Glu Lys  Leu Cys Ser Ser Val  Asn Val Ser Asn Glu  Ile Lys Ser 
    2525                 2530                 2535             


Ser Gly  Asn Thr Met Lys Val  Ile Phe Phe Thr Asp  Gly Ser Arg 
    2540                 2545                 2550             


Pro Tyr  Gly Gly Phe Thr Ala  Ser Tyr Thr Ser Ser  Glu Asp Ala 
    2555                 2560                 2565             


Val Cys  Gly Gly Ser Leu Pro  Asn Thr Pro Glu Gly  Asn Phe Thr 
    2570                 2575                 2580             


Ser Pro  Gly Tyr Asp Gly Val  Arg Asn Tyr Ser Arg  Asn Leu Asn 
    2585                 2590                 2595             


Cys Glu  Trp Thr Leu Ser Asn  Pro Asn Gln Gly Asn  Ser Ser Ile 
    2600                 2605                 2610             


Ser Ile  His Phe Glu Asp Phe  Tyr Leu Glu Ser His  Gln Asp Cys 
    2615                 2620                 2625             


Gln Phe  Asp Val Leu Glu Phe  Arg Val Gly Asp Ala  Asp Gly Pro 
    2630                 2635                 2640             


Leu Met  Trp Arg Leu Cys Gly  Pro Ser Lys Pro Thr  Leu Pro Leu 
    2645                 2650                 2655             


Val Ile  Pro Tyr Ser Gln Val  Trp Ile His Phe Val  Thr Asn Glu 
    2660                 2665                 2670             


Arg Val  Glu His Ile Gly Phe  His Ala Lys Tyr Ser  Phe Thr Asp 
    2675                 2680                 2685             


Cys Gly  Gly Ile Gln Ile Gly  Asp Ser Gly Val Ile  Thr Ser Pro 
    2690                 2695                 2700             


Asn Tyr  Pro Asn Ala Tyr Asp  Ser Leu Thr His Cys  Ser Ser Leu 
    2705                 2710                 2715             


Leu Glu  Ala Pro Gln Gly His  Thr Ile Thr Leu Thr  Phe Ser Asp 
    2720                 2725                 2730             


Phe Asp  Ile Glu Pro His Thr  Thr Cys Ala Trp Asp  Ser Val Thr 
    2735                 2740                 2745             


Val Arg  Asn Gly Gly Ser Pro  Glu Ser Pro Ile Ile  Gly Gln Tyr 
    2750                 2755                 2760             


Cys Gly  Asn Ser Asn Pro Arg  Thr Ile Gln Ser Gly  Ser Asn Gln 
    2765                 2770                 2775             


Leu Val  Val Thr Phe Asn Ser  Asp His Ser Leu Gln  Gly Gly Gly 
    2780                 2785                 2790             


Phe Tyr  Ala Thr Trp Asn Thr  Gln Thr Leu Gly Cys  Gly Gly Ile 
    2795                 2800                 2805             


Phe His  Ser Asp Asn Gly Thr  Ile Arg Ser Pro His  Trp Pro Gln 
    2810                 2815                 2820             


Asn Phe  Pro Glu Asn Ser Arg  Cys Ser Trp Thr Ala  Ile Thr His 
    2825                 2830                 2835             


Lys Ser  Lys His Leu Glu Ile  Ser Phe Asp Asn Asn  Phe Leu Ile 
    2840                 2845                 2850             


Pro Ser  Gly Asp Gly Gln Cys  Gln Asn Ser Phe Val  Lys Val Trp 
    2855                 2860                 2865             


Ala Gly  Thr Glu Glu Val Asp  Lys Ala Leu Leu Ala  Thr Gly Cys 
    2870                 2875                 2880             


Gly Asn  Val Ala Pro Gly Pro  Val Ile Thr Pro Ser  Asn Thr Phe 
    2885                 2890                 2895             


Thr Ala  Val Phe Gln Ser Gln  Glu Ala Pro Ala Gln  Gly Phe Ser 
    2900                 2905                 2910             


Ala Ser  Phe Val Ser Arg Cys  Gly Ser Asn Phe Thr  Gly Pro Ser 
    2915                 2920                 2925             


Gly Tyr  Ile Ile Ser Pro Asn  Tyr Pro Lys Gln Tyr  Asp Asn Asn 
    2930                 2935                 2940             


Met Asn  Cys Thr Tyr Val Ile  Glu Ala Asn Pro Leu  Ser Val Val 
    2945                 2950                 2955             


Leu Leu  Thr Phe Val Ser Phe  His Leu Glu Ala Arg  Ser Ala Val 
    2960                 2965                 2970             


Thr Gly  Ser Cys Val Asn Asp  Gly Val His Ile Ile  Arg Gly Tyr 
    2975                 2980                 2985             


Ser Val  Met Ser Thr Pro Phe  Ala Thr Val Cys Gly  Asp Glu Met 
    2990                 2995                 3000             


Pro Ala  Pro Leu Thr Ile Ala  Gly Pro Val Leu Leu  Asn Phe Tyr 
    3005                 3010                 3015             


Ser Asn  Glu Gln Ile Thr Asp  Phe Gly Phe Lys Phe  Ser Tyr Arg 
    3020                 3025                 3030             


Ile Ile  Ser Cys Gly Gly Val  Phe Asn Phe Ser Ser  Gly Ile Ile 
    3035                 3040                 3045             


Thr Ser  Pro Ala Tyr Ser Tyr  Ala Asp Tyr Pro Asn  Asp Met His 
    3050                 3055                 3060             


Cys Leu  Tyr Thr Ile Thr Val  Ser Asp Asp Lys Val  Ile Glu Leu 
    3065                 3070                 3075             


Lys Phe  Ser Asp Phe Asp Val  Val Pro Ser Thr Ser  Cys Ser His 
    3080                 3085                 3090             


Asp Tyr  Leu Ala Ile Tyr Asp  Gly Ala Asn Thr Ser  Asp Pro Leu 
    3095                 3100                 3105             


Leu Gly  Lys Phe Cys Gly Ser  Lys Arg Pro Pro Asn  Val Lys Ser 
    3110                 3115                 3120             


Ser Asn  Asn Ser Met Leu Leu  Val Phe Lys Thr Asp  Ser Phe Gln 
    3125                 3130                 3135             


Thr Ala  Lys Gly Trp Lys Met  Ser Phe Arg Gln Thr  Leu Gly Pro 
    3140                 3145                 3150             


Gln Gln  Gly Cys Gly Gly Tyr  Leu Thr Gly Ser Asn  Asn Thr Phe 
    3155                 3160                 3165             


Ala Ser  Pro Asp Ser Asp Ser  Asn Gly Met Tyr Asp  Lys Asn Leu 
    3170                 3175                 3180             


Asn Cys  Val Trp Ile Ile Ile  Ala Pro Val Asn Lys  Val Ile His 
    3185                 3190                 3195             


Leu Thr  Phe Asn Thr Phe Ala  Leu Glu Ala Ala Ser  Thr Arg Gln 
    3200                 3205                 3210             


Arg Cys  Leu Tyr Asp Tyr Val  Lys Leu Tyr Asp Gly  Asp Ser Glu 
    3215                 3220                 3225             


Asn Ala  Asn Leu Ala Gly Thr  Phe Cys Gly Ser Thr  Val Pro Ala 
    3230                 3235                 3240             


Pro Phe  Ile Ser Ser Gly Asn  Phe Leu Thr Val Gln  Phe Ile Ser 
    3245                 3250                 3255             


Asp Leu  Thr Leu Glu Arg Glu  Gly Phe Asn Ala Thr  Tyr Thr Ile 
    3260                 3265                 3270             


Met Asp  Met Pro Cys Gly Gly  Thr Tyr Asn Ala Thr  Trp Thr Pro 
    3275                 3280                 3285             


Gln Asn  Ile Ser Ser Pro Asn  Ser Ser Asp Pro Asp  Val Pro Phe 
    3290                 3295                 3300             


Ser Ile  Cys Thr Trp Val Ile  Asp Ser Pro Pro His  Gln Gln Val 
    3305                 3310                 3315             


Lys Ile  Thr Val Trp Ala Leu  Gln Leu Thr Ser Gln  Asp Cys Thr 
    3320                 3325                 3330             


Gln Asn  Tyr Leu Gln Leu Gln  Asp Ser Pro Gln Gly  His Gly Asn 
    3335                 3340                 3345             


Ser Arg  Phe Gln Phe Cys Gly  Arg Asn Ala Ser Ala  Val Pro Val 
    3350                 3355                 3360             


Phe Tyr  Ser Ser Met Ser Thr  Ala Met Val Ile Phe  Lys Ser Gly 
    3365                 3370                 3375             


Val Val  Asn Arg Asn Ser Arg  Met Ser Phe Thr Tyr  Gln Ile Ala 
    3380                 3385                 3390             


Asp Cys  Asn Arg Asp Tyr His  Lys Ala Phe Gly Asn  Leu Arg Ser 
    3395                 3400                 3405             


Pro Gly  Trp Pro Asp Asn Tyr  Asp Asn Asp Lys Asp  Cys Thr Val 
    3410                 3415                 3420             


Thr Leu  Thr Ala Pro Gln Asn  His Thr Ile Ser Leu  Phe Phe His 
    3425                 3430                 3435             


Ser Leu  Gly Ile Glu Asn Ser  Val Glu Cys Arg Asn  Asp Phe Leu 
    3440                 3445                 3450             


Glu Val  Arg Asn Gly Ser Asn  Ser Asn Ser Pro Leu  Leu Gly Lys 
    3455                 3460                 3465             


Tyr Cys  Gly Thr Leu Leu Pro  Asn Pro Val Phe Ser  Gln Asn Asn 
    3470                 3475                 3480             


Glu Leu  Tyr Leu Arg Phe Lys  Ser Asp Ser Val Thr  Ser Asp Arg 
    3485                 3490                 3495             


Gly Tyr  Glu Ile Ile Trp Thr  Ser Ser Pro Ser Gly  Cys Gly Gly 
    3500                 3505                 3510             


Thr Leu  Tyr Gly Asp Arg Gly  Ser Phe Thr Ser Pro  Gly Tyr Pro 
    3515                 3520                 3525             


Gly Thr  Tyr Pro Asn Asn Thr  Tyr Cys Glu Trp Val  Leu Val Ala 
    3530                 3535                 3540             


Pro Ala  Gly Arg Leu Val Thr  Ile Asn Phe Tyr Phe  Ile Ser Ile 
    3545                 3550                 3555             


Asp Asp  Pro Gly Asp Cys Val  Gln Asn Tyr Leu Thr  Leu Tyr Asp 
    3560                 3565                 3570             


Gly Pro  Asn Ala Ser Ser Pro  Ser Ser Gly Pro Tyr  Cys Gly Gly 
    3575                 3580                 3585             


Asp Thr  Ser Ile Ala Pro Phe  Val Ala Ser Ser Asn  Gln Val Phe 
    3590                 3595                 3600             


Ile Lys  Phe His Ala Asp Tyr  Ala Arg Arg Pro Ser  Ala Phe Arg 
    3605                 3610                 3615             


Leu Thr  Trp Asp Ser 
    3620             


<210>  128
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  isoleucine zipper domain

<400>  128

Ile Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr 
1               5                   10                  15      


His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Arg 
            20                  25                  30          


<210>  129
<211>  186
<212>  PRT
<213>  Macaca fascicularis

<400>  129

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys Gln 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Asn Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ala Lys Pro Cys Lys Ala Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Pro Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Pro Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Thr Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Arg Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Arg Gly Pro Ala 
            180                 185     


<210>  130
<211>  192
<212>  PRT
<213>  Mus musculus

<400>  130

Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr Pro Ser Gly 
1               5                   10                  15      


His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met Val Ser Arg 
            20                  25                  30          


Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu Thr Gly Phe 
        35                  40                  45              


Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys Thr Gln Cys 
    50                  55                  60                  


Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr Pro Thr Gln 
65                  70                  75                  80  


Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg Gln Asp Ser 
                85                  90                  95      


Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro Gly His Phe 
            100                 105                 110         


Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu 
        115                 120                 125             


Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu Asp Ala Val 
    130                 135                 140                 


Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu Thr Gln Arg 
145                 150                 155                 160 


Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val Trp Pro Arg 
                165                 170                 175     


Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro Glu Gly Pro 
            180                 185                 190         


<210>  131
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Fc hole chain

<400>  131
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  132
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence human OX40 antigen Fc knob chain

<400>  132
ctgcactgcg tgggcgacac ctaccccagc aacgaccggt gctgccacga gtgcagaccc       60

ggcaacggca tggtgtcccg gtgcagccgg tcccagaaca ccgtgtgcag accttgcggc      120

cctggcttct acaacgacgt ggtgtccagc aagccctgca agccttgtac ctggtgcaac      180

ctgcggagcg gcagcgagcg gaagcagctg tgtaccgcca cccaggatac cgtgtgccgg      240

tgtagagccg gcacccagcc cctggacagc tacaaacccg gcgtggactg cgccccttgc      300

cctcctggcc acttcagccc tggcgacaac caggcctgca agccttggac caactgcacc      360

ctggccggca agcacaccct gcagcccgcc agcaatagca gcgacgccat ctgcgaggac      420

cgggatcctc ctgccaccca gcctcaggaa acccagggcc ctcccgccag acccatcacc      480

gtgcagccta cagaggcctg gcccagaacc agccaggggc ctagcaccag acccgtggaa      540

gtgcctggcg gcagagccgt cgacgaacag ttatattttc agggcggctc acccaaatct      600

gcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      660

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      720

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      780

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      840

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      900

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      960

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgccggga tgagctgacc     1020

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1080

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1140

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1200

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1260

agcctctccc tgtctccggg taaatccgga ggcctgaacg acatcttcga ggcccagaag     1320

attgaatggc acgag                                                      1335


<210>  133
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence cynomolgus OX40 antigen Fc knob chain

<400>  133
ctccactgtg tcggggacac ctaccccagc aacgaccggt gctgtcagga gtgcaggcca       60

ggcaacggga tggtgagccg ctgcaaccgc tcccagaaca cggtgtgccg tccgtgcggg      120

cccggcttct acaacgacgt ggtcagcgcc aagccctgca aggcctgcac atggtgcaac      180

ctcagaagtg ggagtgagcg gaaacagccg tgcacggcca cacaggacac agtctgccgc      240

tgccgggcgg gcacccagcc cctggacagc tacaagcctg gagttgactg tgccccctgc      300

cctccagggc acttctcccc gggcgacaac caggcctgca agccctggac caactgcacc      360

ttggccggga agcacaccct gcagccagcc agcaatagct cggacgccat ctgtgaggac      420

agggaccccc cacccacaca gccccaggag acccagggcc ccccggccag gcccaccact      480

gtccagccca ctgaagcctg gcccagaacc tcacagagac cctccacccg gcccgtggag      540

gtccccaggg gccctgcggt cgacgaacag ttatattttc agggcggctc acccaaatct      600

gcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      660

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      720

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      780

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      840

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      900

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      960

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgccggga tgagctgacc     1020

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1080

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1140

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1200

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1260

agcctctccc tgtctccggg taaatccgga ggcctgaacg acatcttcga ggcccagaag     1320

attgaatggc acgag                                                      1335


<210>  134
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence murine OX40 antigen Fc knob chain

<400>  134
gtgaccgcca gacggctgaa ctgcgtgaag cacacctacc ccagcggcca caagtgctgc       60

agagagtgcc agcccggcca cggcatggtg tccagatgcg accacacacg ggacaccctg      120

tgccaccctt gcgagacagg cttctacaac gaggccgtga actacgatac ctgcaagcag      180

tgcacccagt gcaaccacag aagcggcagc gagctgaagc agaactgcac ccccacccag      240

gataccgtgt gcagatgcag acccggcacc cagcccagac aggacagcgg ctacaagctg      300

ggcgtggact gcgtgccctg ccctcctggc cacttcagcc ccggcaacaa ccaggcctgc      360

aagccctgga ccaactgcac cctgagcggc aagcagacca gacaccccgc cagcgacagc      420

ctggatgccg tgtgcgagga cagaagcctg ctggccaccc tgctgtggga gacacagcgg      480

cccaccttca gacccaccac cgtgcagagc accaccgtgt ggcccagaac cagcgagctg      540

cccagtcctc ctaccctcgt gacacctgag ggccccgtcg acgaacagtt atattttcag      600

ggcggctcac ccaaatctgc agacaaaact cacacatgcc caccgtgccc agcacctgaa      660

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      720

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      780

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      840

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      900

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      960

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1020

tgccgggatg agctgaccaa gaaccaggtc agcctgtggt gcctggtcaa aggcttctat     1080

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1140

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1200

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1260

aaccactaca cgcagaagag cctctccctg tctccgggta aatccggagg cctgaacgac     1320

atcttcgagg cccagaagat tgaatggcac gag                                  1353


<210>  135
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc hole chain

<400>  135

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  136
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human OX40 antigen Fc knob chain

<400>  136

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Asp Glu Gln Leu Tyr 
            180                 185                 190         


Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro 
        195                 200                 205             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                245                 250                 255     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            260                 265                 270         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        275                 280                 285             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    290                 295                 300                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
305                 310                 315                 320 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                325                 330                 335     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            340                 345                 350         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        355                 360                 365             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    370                 375                 380                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
385                 390                 395                 400 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                405                 410                 415     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu 
            420                 425                 430         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        435                 440                 445 


<210>  137
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus OX40 antigen Fc knob chain

<400>  137

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys Gln 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Asn Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ala Lys Pro Cys Lys Ala Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Pro Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Pro Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Thr Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Arg Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Arg Gly Pro Ala Val Asp Glu Gln Leu Tyr 
            180                 185                 190         


Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro 
        195                 200                 205             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                245                 250                 255     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            260                 265                 270         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        275                 280                 285             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    290                 295                 300                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
305                 310                 315                 320 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                325                 330                 335     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            340                 345                 350         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        355                 360                 365             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    370                 375                 380                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
385                 390                 395                 400 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                405                 410                 415     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu 
            420                 425                 430         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        435                 440                 445 


<210>  138
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine OX40 antigen Fc knob chain

<400>  138

Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr Pro Ser Gly 
1               5                   10                  15      


His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met Val Ser Arg 
            20                  25                  30          


Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu Thr Gly Phe 
        35                  40                  45              


Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys Thr Gln Cys 
    50                  55                  60                  


Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr Pro Thr Gln 
65                  70                  75                  80  


Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg Gln Asp Ser 
                85                  90                  95      


Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro Gly His Phe 
            100                 105                 110         


Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu 
        115                 120                 125             


Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu Asp Ala Val 
    130                 135                 140                 


Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu Thr Gln Arg 
145                 150                 155                 160 


Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val Trp Pro Arg 
                165                 170                 175     


Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro Glu Gly Pro 
            180                 185                 190         


Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp 
        195                 200                 205             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                245                 250                 255     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            260                 265                 270         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    290                 295                 300                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        355                 360                 365             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
        435                 440                 445             


Trp His Glu 
    450     


<210>  139
<211>  1613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of library DP88-4

<400>  139
tgaaatacct attgcctacg gcagccgctg gattgttatt actcgcggcc cagccggcca       60

tggccgacat ccagatgacc cagtctcctt ccaccctgtc tgcatctgta ggagaccgtg      120

tcaccatcac ttgccgtgcc agtcagagta ttagtagctg gttggcctgg tatcagcaga      180

aaccagggaa agcccctaag ctcctgatct atgatgcctc cagtttggaa agtggggtcc      240

catcacgttt cagcggcagt ggatccggga cagaattcac tctcaccatc agcagcttgc      300

agcctgatga ttttgcaact tattactgcc aacagtataa tagttattct acgtttggcc      360

agggcaccaa agtcgagatc aagcgtacgg tggctgcacc atctgtcttc atcttcccgc      420

catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct      480

atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg ggtaactccc      540

aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc agcaccctga      600

cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc acccatcagg      660

gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggagcc gcagaacaaa      720

aactcatctc agaagaggat ctgaatggag ccgcagacta caaggacgac gacgacaagg      780

gtgccgcata ataaggcgcg ccaattctat ttcaaggaga cagtcatatg aaatacctgc      840

tgccgaccgc tgctgctggt ctgctgctcc tcgctgccca gccggcgatg gcccaggtgc      900

aattggtgca gtctggggct gaggtgaaga agcctgggtc ctcggtgaag gtctcctgca      960

aggcctccgg aggcacattc agcagctacg ctataagctg ggtgcgacag gcccctggac     1020

aagggctcga gtggatggga gggatcatcc ctatctttgg tacagcaaac tacgcacaga     1080

agttccaggg cagggtcacc attactgcag acaaatccac gagcacagcc tacatggagc     1140

tgagcagcct gagatctgag gacaccgccg tgtattactg tgcgagacta tccccaggcg     1200

gttactatgt tatggatgcc tggggccaag ggaccaccgt gaccgtctcc tcagctagca     1260

ccaaaggccc atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag     1320

cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg tcgtggaact     1380

caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc tcaggactct     1440

actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag acctacatct     1500

gcaacgtgaa tcacaagccc agcaacacca aagtggacaa gaaagttgag cccaaatctt     1560

gtgacgcggc cgcaagcact agtgcccatc accatcacca tcacgccgcg gca            1613


<210>  140
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of Fab light chain Vk1_5

<400>  140
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attctacgtt tggccagggc      300

accaaagtcg agatcaagcg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtg gagccgcaga acaaaaactc      660

atctcagaag aggatctgaa tggagccgca gactacaagg acgacgacga caagggtgcc      720

gca                                                                    723


<210>  141
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vk1_5

<400>  141

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu 
    210                 215                 220                 


Asp Leu Asn Gly Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala 
225                 230                 235                 240 


Ala 
    


<210>  142
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of Fab heavy chain VH1_69

<400>  142
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactatcc      300

ccaggcggtt actatgttat ggatgcctgg ggccaaggga ccaccgtgac cgtctcctca      360

gctagcacca aaggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaaag tggacaagaa agttgagccc      660

aaatcttgtg acgcggccgc aagcactagt gcccatcacc atcaccatca cgccgcggca      720


<210>  143
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab heavy chain VH1_69

<400>  143

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Ala Ala Ala Ser Thr Ser Ala His His His His His His Ala Ala Ala 
225                 230                 235                 240 


<210>  144
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMB3 Primer

<400>  144
caggaaacag ctatgaccat gattac                                            26


<210>  145
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk1_5_L3r_S Primer

<400>  145
ctcgactttg gtgccctggc caaacgtsba atacgaatta tactgttggc agtaataagt       60

tgcaaaatca t                                                            71


<210>  146
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk1_5_L3r_SY Primer

<400>  146
ctcgactttg gtgccctggc caaacgtmhr sgratacgaa ttatactgtt ggcagtaata       60

agttgcaaaa tcat                                                         74


<210>  147
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk1_5_L3r_SPY

<400>  147
ctcgactttg gtgccctggc caaacgtmhh msssgratac gaattatact gttggcagta       60

ataagttgca aaatcat                                                      77


<210>  148
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH31 Primer

<400>  148
acgtttggcc agggcaccaa agtcgag                                           27


<210>  149
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH32 Primer

<400>  149
tctcgcacag taatacacgg cggtgtcc                                          28


<210>  150
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP88-v4-4

<400>  150
ggacaccgcc gtgtattact gtgcgagaga ctactggggc caagggacca ccgtgaccgt       60

ctcc                                                                    64


<210>  151
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP88-v4-6

<400>  151
ggacaccgcc gtgtattact gtgcgagaga ctactggggc caagggacca ccgtgaccgt       60

ctcc                                                                    64


<210>  152
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP88-v4-8

<400>  152
ggacaccgcc gtgtattact gtgcgagaga ctactggggc caagggacca ccgtgaccgt       60

ctcc                                                                    64


<210>  153
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fdseqlong Primer

<400>  153
gacgttagta aatgaatttt ctgtatgagg                                        30


<210>  154
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (Vk3_20/VH3_23) template

<400>  154
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggccgaaa tcgtgttaac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga      120

gccaccctct cttgcagggc cagtcagagt gttagcagca gctacttagc ctggtaccag      180

cagaaacctg gccaggctcc caggctcctc atctatggag catccagcag ggccactggc      240

atcccagaca ggttcagtgg cagtggatcc gggacagact tcactctcac catcagcaga      300

ctggagcctg aagattttgc agtgtattac tgtcagcagt atggtagctc accgctgacg      360

ttcggccagg ggaccaaagt ggaaatcaaa cgtacggtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg tggagccgca      720

catcaccatc accatcacgg agccgcagac tacaaggacg acgacgacaa gggtgccgca      780

taataaggcg cgccaattct atttcaagga gacagtcata tgaaatacct gctgccgacc      840

gctgctgctg gtctgctgct cctcgctgcc cagccggcga tggccgaggt gcaattgctg      900

gagtctgggg gaggcttggt acagcctggg gggtccctga gactctcctg tgcagcctcc      960

ggattcacct ttagcagtta tgccatgagc tgggtccgcc aggctccagg gaaggggctg     1020

gagtgggtct cagctattag tggtagtggt ggtagcacat actacgcaga ctccgtgaag     1080

ggccggttca ccatctccag agacaattcc aagaacacgc tgtatctgca gatgaacagc     1140

ctgagagccg aggacacggc cgtatattac tgtgcgaaac cgtttccgta ttttgactac     1200

tggggccaag gaaccctggt caccgtctcg agtgctagca ccaaaggccc atcggtcttc     1260

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc     1320

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc     1380

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg     1440

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc     1500

agcaacacca aagtggacaa gaaagttgag cccaaatctt gtgacgcggc cgcagaacaa     1560

aaactcatct cagaagagga tctgaatgcc gcggca                               1596


<210>  155
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vk3_20

<400>  155
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct gacgttcggc      300

caggggacca aagtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagc cgcacatcac      660

catcaccatc acggagccgc agactacaag gacgacgacg acaagggtgc cgca            714


<210>  156
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vk3_20

<400>  156

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Gly Ala Ala His His His His His His 
    210                 215                 220                 


Gly Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala 
225                 230                 235             


<210>  157
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab heavy chain VH3_23

<400>  157
gaggtgcaat tgctggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaccgttt      300

ccgtattttg actactgggg ccaaggaacc ctggtcaccg tctcgagtgc tagcaccaaa      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaagtg gacaagaaag ttgagcccaa atcttgtgac      660

gcggccgcag aacaaaaact catctcagaa gaggatctga atgccgcggc a               711


<210>  158
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab heavy chain VH3_23 (DP47)

<400>  158

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ala Ala Ala Glu 
    210                 215                 220                 


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ala Ala Ala 
225                 230                 235         


<210>  159
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS64 Primer

<400>  159
acgttcggcc aggggaccaa agtgg                                             25


<210>  160
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47CDR3_ba Primer

<400>  160
cgcacagtaa tatacggccg tgtcc                                             25


<210>  161
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47-v4-4

<400>  161
cgaggacacg gccgtatatt actgtgcgga ctactggggc caaggaaccc tggtcaccgt       60

ctcg                                                                    64


<210>  162
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47-v4-6

<400>  162
cgaggacacg gccgtatatt actgtgcgga ctactggggc caaggaaccc tggtcaccgt       60

ctcg                                                                    64


<210>  163
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47-v4-8

<400>  163
cgaggacacg gccgtatatt actgtgcgga ctactggggc caaggaaccc tggtcaccgt       60

ctcg                                                                    64


<210>  164
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fdseqlong

<400>  164
gacgttagta aatgaatttt ctgtatgagg                                        30


<210>  165
<211>  1605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl3_19/VH3_23 library template

<400>  165
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggcctcgt ctgagctgac tcaggaccct gctgtgtctg tggccttggg acagacagtc      120

aggatcacat gccaaggaga cagcctcaga agttattatg caagctggta ccagcagaag      180

ccaggacagg cccctgtact tgtcatctat ggtaaaaaca accggccctc agggatccca      240

gaccgattct ctggctccag ctcaggaaac acagcttcct tgaccatcac tggggctcag      300

gcggaagatg aggctgacta ttactgtaac tcccgtgata gtagcggtaa tcatgtggta      360

ttcggcggag ggaccaagct gaccgtccta ggacaaccca aggctgcccc cagcgtgacc      420

ctgttccccc ccagcagcga ggaattgcag gccaacaagg ccaccctggt ctgcctgatc      480

agcgacttct acccaggcgc cgtgaccgtg gcctggaagg ccgacagcag ccccgtgaag      540

gccggcgtgg agaccaccac ccccagcaag cagagcaaca acaagtacgc cgccagcagc      600

tacctgagcc tgacccccga gcagtggaag agccacaggt cctacagctg ccaggtgacc      660

cacgagggca gcaccgtgga gaaaaccgtg gcccccaccg agtgcagcgg agccgcagaa      720

caaaaactca tctcagaaga ggatctgaat ggagccgcag actacaagga cgacgacgac      780

aagggtgccg cataataagg cgcgccaatt ctatttcaag gagacagtca tatgaaatac      840

ctgctgccga ccgctgctgc tggtctgctg ctcctcgctg cccagccggc gatggccgag      900

gtgcaattgc tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      960

tgtgcagcct ccggattcac ctttagcagt tatgccatga gctgggtccg ccaggctcca     1020

gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca     1080

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg     1140

cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa accgtttccg     1200

tattttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaaaggc     1260

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg     1320

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc     1380

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc     1440

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg     1500

aatcacaagc ccagcaacac caaagtggac aagaaagttg agcccaaatc ttgtgacgcg     1560

gccgcaagca ctagtgccca tcaccatcac catcacgccg cggca                     1605


<210>  166
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vl3_19

<400>  166
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gatagtagcg gtaatcatgt ggtattcggc      300

ggagggacca agctgaccgt cctaggacaa cccaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggaatt gcaggccaac aaggccaccc tggtctgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggagaaaac cgtggccccc accgagtgca gcggagccgc agaacaaaaa      660

ctcatctcag aagaggatct gaatggagcc gcagactaca aggacgacga cgacaagggt      720

gccgca                                                                 726


<210>  167
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vl3_19

<400>  167

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu 
    210                 215                 220                 


Glu Asp Leu Asn Gly Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
225                 230                 235                 240 


Ala Ala 
        


<210>  168
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMB3 lambda-DP47 library

<400>  168
caggaaacag ctatgaccat gattac                                            26


<210>  169
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl_3_19_L3r_V lambda-DP47 library

<400>  169
ggacggtcag cttggtccct ccgccgaata cvhvattacc gctactatca cgggagttac       60

agtaatagtc agcctcatct tccgc                                             85


<210>  170
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl_3_19_L3r_HV lambda-DP47

<400>  170
ggacggtcag cttggtccct ccgccgaata ccmmatgatt accgctacta tcacgggagt       60

tacagtaata gtcagcctca tcttccgc                                          88


<210>  171
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl_3_19_L3r_HLV lambda-DP47

<400>  171
ggacggtcag cttggtccct ccgccgaata crhmvwgatg attaccgcta ctatcacggg       60

agttacagta atagtcagcc tcatcttccg c                                      91


<210>  172
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH80 lambda-DP47

<400>  172
ttcggcggag ggaccaagct gaccgtcc                                          28


<210>  173
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (8H9 ) VL

<400>  173
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gttatgcctc ataatcgcgt attcggcgga      300

gggaccaagc tgaccgtc                                                    318


<210>  174
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (8H9) VH

<400>  174
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgttttc      300

taccgtggtg gtgtttctat ggactactgg ggccaaggaa ccctggtcac cgtctcgagt      360


<210>  175
<211>  321
<212>  DNA
<213>  Artificial  Sequence

<220>
<223>  DNA (49B4) VL

<400>  175
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatagttcgc agccgtatac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  176
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (49B4) VH

<400>  176
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctca            354


<210>  177
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (1G4) VL

<400>  177
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatatttcgt attccatgtt gacgtttggc      300

cagggcacca aagtcgagat caag                                             324


<210>  178
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (1G4) VH

<400>  178
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

ggttctatgg actactgggg ccaagggacc accgtgaccg tctcctca                   348


<210>  179
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (20B7) VL

<400>  179
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatcaggctt tttcgcttac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  180
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (20B7) VH

<400>  180
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagttaac      300

tacccgtact cttactgggg tgacttcgac tactggggcc aagggaccac cgtgaccgtc      360

tcctca                                                                 366


<210>  181
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-563) VL

<400>  181
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caag                                             324


<210>  182
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-563) VH

<400>  182
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcttgacgtt      300

ggtgctttcg actactgggg ccaaggagcc ctggtcaccg tctcgagt                   348


<210>  183
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-564) VL

<400>  183
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caag                                             324


<210>  184
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-564) VH

<400>  184
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gttcgacgtt      300

ggtccgttcg actactgggg ccaaggaacc ctggtcaccg tctcgagt                   348


<210>  185
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (17A9) VL

<400>  185
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gttatgcctc ataatcgcgt attcggcgga      300

gggaccaagc tgaccgtc                                                    318


<210>  186
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (17A9) VH

<400>  186
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgttttc      300

taccgtggtg gtgtttctat ggactactgg ggccaaggaa ccctggtcac cgtctcgagt      360


<210>  187
<211>  163
<212>  PRT
<213>  Macaca fascicularis

<400>  187

Leu Gln Asp Leu Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Ser Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Lys Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Ile Ser Gly Tyr His Cys Leu Gly Ala Glu Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Ala Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln 
            


<210>  188
<211>  164
<212>  PRT
<213>  Mus musculus

<400>  188

Val Gln Asn Ser Cys Asp Asn Cys Gln Pro Gly Thr Phe Cys Arg Lys 
1               5                   10                  15      


Tyr Asn Pro Val Cys Lys Ser Cys Pro Pro Ser Thr Phe Ser Ser Ile 
            20                  25                  30          


Gly Gly Gln Pro Asn Cys Asn Ile Cys Arg Val Cys Ala Gly Tyr Phe 
        35                  40                  45              


Arg Phe Lys Lys Phe Cys Ser Ser Thr His Asn Ala Glu Cys Glu Cys 
    50                  55                  60                  


Ile Glu Gly Phe His Cys Leu Gly Pro Gln Cys Thr Arg Cys Glu Lys 
65                  70                  75                  80  


Asp Cys Arg Pro Gly Gln Glu Leu Thr Lys Gln Gly Cys Lys Thr Cys 
                85                  90                  95      


Ser Leu Gly Thr Phe Asn Asp Gln Asn Gly Thr Gly Val Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Arg Ser Val Leu Lys Thr Gly Thr 
        115                 120                 125             


Thr Glu Lys Asp Val Val Cys Gly Pro Pro Val Val Ser Phe Ser Pro 
    130                 135                 140                 


Ser Thr Thr Ile Ser Val Thr Pro Glu Gly Gly Pro Gly Gly His Ser 
145                 150                 155                 160 


Leu Gln Val Leu 
                


<210>  189
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA human 4-1BB antigen Fc knob chain

<400>  189
ctgcaggacc cctgcagcaa ctgccctgcc ggcaccttct gcgacaacaa ccggaaccag       60

atctgcagcc cctgcccccc caacagcttc agctctgccg gcggacagcg gacctgcgac      120

atctgcagac agtgcaaggg cgtgttcaga acccggaaag agtgcagcag caccagcaac      180

gccgagtgcg actgcacccc cggcttccat tgtctgggag ccggctgcag catgtgcgag      240

caggactgca agcagggcca ggaactgacc aagaagggct gcaaggactg ctgcttcggc      300

accttcaacg accagaagcg gggcatctgc cggccctgga ccaactgtag cctggacggc      360

aagagcgtgc tggtcaacgg caccaaagaa cgggacgtcg tgtgcggccc cagccctgct      420

gatctgtctc ctggggccag cagcgtgacc cctcctgccc ctgccagaga gcctggccac      480

tctcctcagg tcgacgaaca gttatatttt cagggcggct cacccaaatc tgcagacaaa      540

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      600

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      660

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      720

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      780

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      840

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag      900

ccccgagaac cacaggtgta caccctgccc ccatgccggg atgagctgac caagaaccag      960

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1020

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1080

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1140

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1200

ctgtctccgg gtaaatccgg aggcctgaac gacatcttcg aggcccagaa gattgaatgg     1260

cacgag                                                                1266


<210>  190
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA cynomolgus 4-1BB antigen Fc knob chain

<400>  190
ttgcaggatc tgtgtagtaa ctgcccagct ggtacattct gtgataataa caggagtcag       60

atttgcagtc cctgtcctcc aaatagtttc tccagcgcag gtggacaaag gacctgtgac      120

atatgcaggc agtgtaaagg tgttttcaag accaggaagg agtgttcctc caccagcaat      180

gcagagtgtg actgcatttc agggtatcac tgcctggggg cagagtgcag catgtgtgaa      240

caggattgta aacaaggtca agaattgaca aaaaaaggtt gtaaagactg ttgctttggg      300

acatttaatg accagaaacg tggcatctgt cgcccctgga caaactgttc tttggatgga      360

aagtctgtgc ttgtgaatgg gacgaaggag agggacgtgg tctgcggacc atctccagcc      420

gacctctctc caggagcatc ctctgcgacc ccgcctgccc ctgcgagaga gccaggacac      480

tctccgcagg tcgacgaaca gttatatttt cagggcggct cacccaaatc tgcagacaaa      540

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      600

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      660

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      720

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      780

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      840

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag      900

ccccgagaac cacaggtgta caccctgccc ccatgccggg atgagctgac caagaaccag      960

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1020

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1080

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1140

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1200

ctgtctccgg gtaaatccgg aggcctgaac gacatcttcg aggcccagaa gattgaatgg     1260

cacgag                                                                1266


<210>  191
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA murine 4-1BB antigen Fc knob chain

<400>  191
gtgcagaaca gctgcgacaa ctgccagccc ggcaccttct gccggaagta caaccccgtg       60

tgcaagagct gcccccccag caccttcagc agcatcggcg gccagcccaa ctgcaacatc      120

tgcagagtgt gcgccggcta cttccggttc aagaagttct gcagcagcac ccacaacgcc      180

gagtgcgagt gcatcgaggg cttccactgc ctgggccccc agtgcaccag atgcgagaag      240

gactgcagac ccggccagga actgaccaag cagggctgta agacctgcag cctgggcacc      300

ttcaacgacc agaacgggac cggcgtgtgc cggccttgga ccaattgcag cctggacggg      360

agaagcgtgc tgaaaaccgg caccaccgag aaggacgtcg tgtgcggccc tcccgtggtg      420

tccttcagcc ctagcaccac catcagcgtg acccctgaag gcggccctgg cggacactct      480

ctgcaggtcc tggtcgacga acagttatat tttcagggcg gctcacccaa atctgcagac      540

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      600

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      660

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      720

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      780

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      840

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg      900

cagccccgag aaccacaggt gtacaccctg cccccatgcc gggatgagct gaccaagaac      960

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1020

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1080

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1140

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1200

tccctgtctc cgggtaaatc cggaggcctg aacgacatct tcgaggccca gaagattgaa     1260

tggcacgag                                                             1269


<210>  192
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human 4-1BB antigen Fc knob chain

<400>  192

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro Lys 
                165                 170                 175     


Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            180                 185                 190         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        195                 200                 205             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    210                 215                 220                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
225                 230                 235                 240 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                245                 250                 255     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            260                 265                 270         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        275                 280                 285             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    290                 295                 300                 


Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
305                 310                 315                 320 


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                325                 330                 335     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            340                 345                 350         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        355                 360                 365             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    370                 375                 380                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
385                 390                 395                 400 


Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                405                 410                 415     


Lys Ile Glu Trp His Glu 
            420         


<210>  193
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus 4-1BB antigen

Fc knob chain

<400>  193

Leu Gln Asp Leu Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Ser Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Lys Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Ile Ser Gly Tyr His Cys Leu Gly Ala Glu Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Ala Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro Lys 
                165                 170                 175     


Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            180                 185                 190         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        195                 200                 205             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    210                 215                 220                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
225                 230                 235                 240 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                245                 250                 255     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            260                 265                 270         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        275                 280                 285             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    290                 295                 300                 


Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
305                 310                 315                 320 


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                325                 330                 335     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            340                 345                 350         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        355                 360                 365             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    370                 375                 380                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
385                 390                 395                 400 


Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                405                 410                 415     


Lys Ile Glu Trp His Glu 
            420         


<210>  194
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine 4-1BB antigen Fc knob chain

<400>  194

Val Gln Asn Ser Cys Asp Asn Cys Gln Pro Gly Thr Phe Cys Arg Lys 
1               5                   10                  15      


Tyr Asn Pro Val Cys Lys Ser Cys Pro Pro Ser Thr Phe Ser Ser Ile 
            20                  25                  30          


Gly Gly Gln Pro Asn Cys Asn Ile Cys Arg Val Cys Ala Gly Tyr Phe 
        35                  40                  45              


Arg Phe Lys Lys Phe Cys Ser Ser Thr His Asn Ala Glu Cys Glu Cys 
    50                  55                  60                  


Ile Glu Gly Phe His Cys Leu Gly Pro Gln Cys Thr Arg Cys Glu Lys 
65                  70                  75                  80  


Asp Cys Arg Pro Gly Gln Glu Leu Thr Lys Gln Gly Cys Lys Thr Cys 
                85                  90                  95      


Ser Leu Gly Thr Phe Asn Asp Gln Asn Gly Thr Gly Val Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Arg Ser Val Leu Lys Thr Gly Thr 
        115                 120                 125             


Thr Glu Lys Asp Val Val Cys Gly Pro Pro Val Val Ser Phe Ser Pro 
    130                 135                 140                 


Ser Thr Thr Ile Ser Val Thr Pro Glu Gly Gly Pro Gly Gly His Ser 
145                 150                 155                 160 


Leu Gln Val Leu Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro 
                165                 170                 175     


Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            180                 185                 190         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        275                 280                 285             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                405                 410                 415     


Gln Lys Ile Glu Trp His Glu 
            420             


<210>  195
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer MS63

<400>  195
tttcgcacag taatatacgg ccgtgtcc                                          28


<210>  196
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 4-1BB(12B3)  VL

<400>  196
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatcattcgt atccgcagac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  197
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 4-1BB(12B3)  VH

<400>  197
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagatctgaa      300

ttccgtttct acgctgactt cgactactgg ggccaaggga ccaccgtgac cgtctcctca      360


<210>  198
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 4-1BB(25G7)  VL

<400>  198
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactccctt gataggcgcg gtatgtgggt attcggcgga      300

gggaccaagc tgaccgtc                                                    318


<210>  199
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 4-1BB(25G7)  VH

<400>  199
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgacgac      300

ccgtggccgc cgttcgacta ctggggccaa ggaaccctgg tcaccgtctc gagt            354


<210>  200
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 4-1BB(11D5)  VL

<400>  200
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag cttaattcgt atcctcagac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  201
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 4-1BB(11D5)  VH

<400>  201
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagatctact      300

ctgatctacg gttacttcga ctactggggc caagggacca ccgtgaccgt ctcctca         357


<210>  202
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 4-1BB(9B11)  VL

<400>  202
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag gttaattctt atccgcagac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  203
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 4-1BB(9B11)  VH

<400>  203
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagatcttct      300

ggtgcttacc cgggttactt cgactactgg ggccaaggga ccaccgtgac cgtctcctca      360


<210>  204
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 4-1BB(20G2)  VL

<400>  204
gacatccaga tgacccagtc tccatccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag cagcactcgt attatacgtt tggccagggc      300

accaaagtcg agatcaag                                                    318


<210>  205
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 4-1BB(20G2)  VH

<400>  205
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagatcttac      300

tactgggaat cttacccgtt cgactactgg ggccaaggga ccaccgtgac cgtctccagc      360


<210>  206
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 12B3 P329GLALA IgG1 light chain

<400>  206
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatcattcgt atccgcagac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  207
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 12B3 P329GLALA IgG1 heavy chain

<400>  207
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagatctgaa      300

ttccgtttct acgctgactt cgactactgg ggccaaggga ccaccgtgac cgtctcctca      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc tgcaggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  208
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12B3 P329GLALA IgG1 light chain

<400>  208

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  209
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12B3 P329GLALA IgG1 heavy chain

<400>  209

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Phe Arg Phe Tyr Ala Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  210
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 25G7 P329GLALA IgG1 light chain

<400>  210
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactccctt gataggcgcg gtatgtgggt attcggcgga      300

gggaccaagc tgaccgtcct aggtcaaccc aaggctgccc ccagcgtgac cctgttcccc      360

cccagcagcg aggaactgca ggccaacaag gccaccctgg tctgcctgat cagcgacttc      420

tacccaggcg ccgtgaccgt ggcctggaag gccgacagca gccccgtgaa ggccggcgtg      480

gagaccacca cccccagcaa gcagagcaac aacaagtacg ccgccagcag ctacctgagc      540

ctgacccccg agcagtggaa gagccacagg tcctacagct gccaggtgac ccacgagggc      600

agcaccgtgg agaaaaccgt ggcccccacc gagtgcagc                             639


<210>  211
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 25G7 P329GLALA IgG1 heavy chain

<400>  211
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgacgac      300

ccgtggccgc cgttcgacta ctggggccaa ggaaccctgg tcaccgtctc gagtgctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  212
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25G7 P329GLALA IgG1 light chain

<400>  212

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Leu Asp Arg Arg Gly Met Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  213
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25G7 P329GLALA IgG1 heavy chain

<400>  213

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Pro Trp Pro Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  214
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (8H9/28H1) Light chain (LC) (pCON184)

<400>  214
cattccgaca tccagatgac ccagtctcct tccaccctgt ctgcatctgt aggagaccgt       60

gtcaccatca cttgccgtgc cagtcagagt attagtagct ggttggcctg gtatcagcag      120

aaaccaggga aagcccctaa gctcctgatc tatgatgcct ccagtttgga aagtggggtc      180

ccatcacgtt tcagcggcag tggatccggg acagaattca ctctcaccat cagcagcttg      240

cagcctgatg attttgcaac ttattactgc caacagtatt tgacgtattc gcggtttacg      300

tttggccagg gcaccaaagt cgagatcaag cgtacggtgg ctgcaccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  215
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (8H9/28H1) CMP chain pETR12239

<400>  215
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

ggttggatgg actactgggg ccaagggacc accgtgaccg tctcctcagc tagcacaaag      360

ggacctagcg tgttccccct ggcccccagc agcaagtcta catctggcgg aacagccgcc      420

ctgggctgcc tcgtgaagga ctactttccc gagcccgtga ccgtgtcctg gaactctggc      480

gctctgacaa gcggcgtgca cacctttcca gccgtgctgc agagcagcgg cctgtactct      540

ctgagcagcg tcgtgacagt gcccagcagc tctctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggaacccaa gagctgcgac      660

ggcggagggg gatctggcgg cggaggatcc gaggaagatc cttgcgcctg cgagagcctc      720

gtgaagttcc aggccaaggt ggaaggactg ctgcaggccc tgacccggaa actggaagcc      780

gtgtccaagc ggctggccat cctggaaaac accgtggtgt ccggaggcgg gggtagcggc      840

ggagggggct ctggcggtgg cgggtctgga ggcgggggtt cagaagtgca gctgctggaa      900

tctggcggcg gactggtgca gcctggcgga tctctgagac tgagctgtgc cgccagcggc      960

ttcaccttta gcagccacgc catgagctgg gtgcgccagg cccctggaaa gtgcctggaa     1020

tgggtgtccg ccatctgggc cagcggcgag cagtactacg ccgatagcgt gaagggccgg     1080

ttcaccatca gccgggacaa cagcaagaac accctgtacc tgcagatgaa cagcctgcgg     1140

gccgaggaca ccgccgtgta ctattgtgcc aagggctggc tgggcaactt cgactattgg     1200

ggccagggca ccctcgtgac cgtgtctagc ggagggggcg gaagtggtgg cgggggaagc     1260

ggcgggggtg gcagcggagg gggcggatct gaaattgtgc tgacccagag ccctggcacc     1320

ctgagcctgt ctccaggcga aagagccaca ctgagctgca gagccagcca gagcgtgtcc     1380

agaagctacc tggcctggta tcagcagaag cccggacagg cccccagact gctgatcatc     1440

ggcgcctcta caagagccac cggcatcccc gatagattca gcggctctgg cagcggcacc     1500

gacttcaccc tgaccatcag cagactggaa cccgaggact ttgccgtgta ttactgccag     1560

cagggccaag tgatcccccc cacctttggc tgtggcacaa aggtggaaat caaa           1614


<210>  216
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (1G4/28H1) LC (pCON251)

<400>  216
cattcggaca tccagatgac ccagtctcct tccaccctgt ctgcatctgt aggagaccgt       60

gtcaccatca cttgccgtgc cagtcagagt attagtagct ggttggcctg gtatcagcag      120

aaaccaggga aagcccctaa gctcctgatc tatgatgcct ccagtttgga aagtggggtc      180

ccatcacgtt tcagcggcag tggatccggg acagaattca ctctcaccat cagcagcttg      240

cagcctgatg attttgcaac ttattactgc caacagtata tttcgtattc catgttgacg      300

tttggccagg gcaccaaagt cgagatcaag cgtacggtgg ctgcaccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t               651


<210>  217
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (1G4/28H1)CMP chain (pETR12640)

<400>  217
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

ggttctatgg actactgggg ccaagggacc accgtgaccg tctcctcagc tagcacaaag      360

ggacctagcg tgttccccct ggcccccagc agcaagtcta catctggcgg aacagccgcc      420

ctgggctgcc tcgtgaagga ctactttccc gagcccgtga ccgtgtcctg gaactctggc      480

gctctgacaa gcggcgtgca cacctttcca gccgtgctgc agagcagcgg cctgtactct      540

ctgagcagcg tcgtgacagt gcccagcagc tctctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggaacccaa gagctgcgac      660

ggcggagggg gatctggcgg cggaggatcc gaggaagatc cttgcgcctg cgagagcctc      720

gtgaagttcc aggccaaggt ggaaggactg ctgcaggccc tgacccggaa actggaagcc      780

gtgtccaagc ggctggccat cctggaaaac accgtggtgt ccggaggcgg gggtagcggc      840

ggagggggct ctggcggtgg cgggtctgga ggcgggggtt cagaagtgca gctgctggaa      900

tctggcggcg gactggtgca gcctggcgga tctctgagac tgagctgtgc cgccagcggc      960

ttcaccttta gcagccacgc catgagctgg gtgcgccagg cccctggaaa gtgcctggaa     1020

tgggtgtccg ccatctgggc cagcggcgag cagtactacg ccgatagcgt gaagggccgg     1080

ttcaccatca gccgggacaa cagcaagaac accctgtacc tgcagatgaa cagcctgcgg     1140

gccgaggaca ccgccgtgta ctattgtgcc aagggctggc tgggcaactt cgactattgg     1200

ggccagggca ccctcgtgac cgtgtctagc ggagggggcg gaagtggtgg cgggggaagc     1260

ggcgggggtg gcagcggagg gggcggatct gaaattgtgc tgacccagag ccctggcacc     1320

ctgagcctgt ctccaggcga aagagccaca ctgagctgca gagccagcca gagcgtgtcc     1380

agaagctacc tggcctggta tcagcagaag cccggacagg cccccagact gctgatcatc     1440

ggcgcctcta caagagccac cggcatcccc gatagattca gcggctctgg cagcggcacc     1500

gacttcaccc tgaccatcag cagactggaa cccgaggact ttgccgtgta ttactgccag     1560

cagggccaag tgatcccccc cacctttggc tgtggcacaa aggtggaaat caaa           1614


<210>  218
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (49B4/28H1) LC (pCON323)

<400>  218
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatagttcgc agccgtatac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  219
<211>  1620
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (49B4/28H1) CMP chain (pETR12899)

<400>  219
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

acaaagggac ctagcgtgtt ccccctggcc cccagcagca agtctacatc tggcggaaca      420

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactctctga gcagcgtcgt gacagtgccc agcagctctc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga acccaagagc      660

tgcgacggcg gagggggatc tggcggcgga ggatccgagg aagatccttg cgcctgcgag      720

agcctcgtga agttccaggc caaggtggaa ggactgctgc aggccctgac ccggaaactg      780

gaagccgtgt ccaagcggct ggccatcctg gaaaacaccg tggtgtccgg aggcgggggt      840

agcggcggag ggggctctgg cggtggcggg tctggaggcg ggggttcaga agtgcagctg      900

ctggaatctg gcggcggact ggtgcagcct ggcggatctc tgagactgag ctgtgccgcc      960

agcggcttca cctttagcag ccacgccatg agctgggtgc gccaggcccc tggaaagtgc     1020

ctggaatggg tgtccgccat ctgggccagc ggcgagcagt actacgccga tagcgtgaag     1080

ggccggttca ccatcagccg ggacaacagc aagaacaccc tgtacctgca gatgaacagc     1140

ctgcgggccg aggacaccgc cgtgtactat tgtgccaagg gctggctggg caacttcgac     1200

tattggggcc agggcaccct cgtgaccgtg tctagcggag ggggcggaag tggtggcggg     1260

ggaagcggcg ggggtggcag cggagggggc ggatctgaaa ttgtgctgac ccagagccct     1320

ggcaccctga gcctgtctcc aggcgaaaga gccacactga gctgcagagc cagccagagc     1380

gtgtccagaa gctacctggc ctggtatcag cagaagcccg gacaggcccc cagactgctg     1440

atcatcggcg cctctacaag agccaccggc atccccgata gattcagcgg ctctggcagc     1500

ggcaccgact tcaccctgac catcagcaga ctggaacccg aggactttgc cgtgtattac     1560

tgccagcagg gccaagtgat cccccccacc tttggctgtg gcacaaaggt ggaaatcaaa     1620


<210>  220
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (21H4/28H1) LC (pETR12026)

<400>  220
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatcagacgt atcctgttac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  221
<211>  1629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (21H4/28H1) CMP chain (pETR12810)

<400>  221
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagacccg      300

cgtggtccgt acttcccgta cttcgactac tggggccaag ggaccaccgt gaccgtctcc      360

tcagctagca caaagggacc tagcgtgttc cccctggccc ccagcagcaa gtctacatct      420

ggcggaacag ccgccctggg ctgcctcgtg aaggactact ttcccgagcc cgtgaccgtg      480

tcctggaact ctggcgctct gacaagcggc gtgcacacct ttccagccgt gctgcagagc      540

agcggcctgt actctctgag cagcgtcgtg acagtgccca gcagctctct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggaa      660

cccaagagct gcgacggcgg agggggatct ggcggcggag gatccgagga agatccttgc      720

gcctgcgaga gcctcgtgaa gttccaggcc aaggtggaag gactgctgca ggccctgacc      780

cggaaactgg aagccgtgtc caagcggctg gccatcctgg aaaacaccgt ggtgtccgga      840

ggcgggggta gcggcggagg gggctctggc ggtggcgggt ctggaggcgg gggttcagaa      900

gtgcagctgc tggaatctgg cggcggactg gtgcagcctg gcggatctct gagactgagc      960

tgtgccgcca gcggcttcac ctttagcagc cacgccatga gctgggtgcg ccaggcccct     1020

ggaaagtgcc tggaatgggt gtccgccatc tgggccagcg gcgagcagta ctacgccgat     1080

agcgtgaagg gccggttcac catcagccgg gacaacagca agaacaccct gtacctgcag     1140

atgaacagcc tgcgggccga ggacaccgcc gtgtactatt gtgccaaggg ctggctgggc     1200

aacttcgact attggggcca gggcaccctc gtgaccgtgt ctagcggagg gggcggaagt     1260

ggtggcgggg gaagcggcgg gggtggcagc ggagggggcg gatctgaaat tgtgctgacc     1320

cagagccctg gcaccctgag cctgtctcca ggcgaaagag ccacactgag ctgcagagcc     1380

agccagagcg tgtccagaag ctacctggcc tggtatcagc agaagcccgg acaggccccc     1440

agactgctga tcatcggcgc ctctacaaga gccaccggca tccccgatag attcagcggc     1500

tctggcagcg gcaccgactt caccctgacc atcagcagac tggaacccga ggactttgcc     1560

gtgtattact gccagcaggg ccaagtgatc ccccccacct ttggctgtgg cacaaaggtg     1620

gaaatcaaa                                                             1629


<210>  222
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (CLC563/28H1) LC (pCON586)

<400>  222
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  223
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (CLC563/28H1) CMP chain (pETR12898)

<400>  223
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcttgacgtt      300

ggtgctttcg actactgggg ccaaggagcc ctggtcaccg tctcgagtgc tagcacaaag      360

ggacctagcg tgttccccct ggcccccagc agcaagtcta catctggcgg aacagccgcc      420

ctgggctgcc tcgtgaagga ctactttccc gagcccgtga ccgtgtcctg gaactctggc      480

gctctgacaa gcggcgtgca cacctttcca gccgtgctgc agagcagcgg cctgtactct      540

ctgagcagcg tcgtgacagt gcccagcagc tctctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggaacccaa gagctgcgac      660

ggcggagggg gatctggcgg cggaggatcc gaggaagatc cttgcgcctg cgagagcctc      720

gtgaagttcc aggccaaggt ggaaggactg ctgcaggccc tgacccggaa actggaagcc      780

gtgtccaagc ggctggccat cctggaaaac accgtggtgt ccggaggcgg gggtagcggc      840

ggagggggct ctggcggtgg cgggtctgga ggcgggggtt cagaagtgca gctgctggaa      900

tctggcggcg gactggtgca gcctggcgga tctctgagac tgagctgtgc cgccagcggc      960

ttcaccttta gcagccacgc catgagctgg gtgcgccagg cccctggaaa gtgcctggaa     1020

tgggtgtccg ccatctgggc cagcggcgag cagtactacg ccgatagcgt gaagggccgg     1080

ttcaccatca gccgggacaa cagcaagaac accctgtacc tgcagatgaa cagcctgcgg     1140

gccgaggaca ccgccgtgta ctattgtgcc aagggctggc tgggcaactt cgactattgg     1200

ggccagggca ccctcgtgac cgtgtctagc ggagggggcg gaagtggtgg cgggggaagc     1260

ggcgggggtg gcagcggagg gggcggatct gaaattgtgc tgacccagag ccctggcacc     1320

ctgagcctgt ctccaggcga aagagccaca ctgagctgca gagccagcca gagcgtgtcc     1380

agaagctacc tggcctggta tcagcagaag cccggacagg cccccagact gctgatcatc     1440

ggcgcctcta caagagccac cggcatcccc gatagattca gcggctctgg cagcggcacc     1500

gacttcaccc tgaccatcag cagactggaa cccgaggact ttgccgtgta ttactgccag     1560

cagggccaag tgatcccccc cacctttggc tgtggcacaa aggtggaaat caaa           1614


<210>  224
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (20B7/28H1) LC (pCON260)

<400>  224
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatcaggctt tttcgcttac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  225
<211>  1632
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3+3 (20B7/28H1) CMP chain (pETR12639)

<400>  225
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagttaac      300

tacccgtact cttactgggg tgacttcgac tactggggcc aagggaccac cgtgaccgtc      360

tcctcagcta gcacaaaggg acctagcgtg ttccccctgg cccccagcag caagtctaca      420

tctggcggaa cagccgccct gggctgcctc gtgaaggact actttcccga gcccgtgacc      480

gtgtcctgga actctggcgc tctgacaagc ggcgtgcaca cctttccagc cgtgctgcag      540

agcagcggcc tgtactctct gagcagcgtc gtgacagtgc ccagcagctc tctgggcacc      600

cagacctaca tctgcaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gaacccaaga gctgcgacgg cggaggggga tctggcggcg gaggatccga ggaagatcct      720

tgcgcctgcg agagcctcgt gaagttccag gccaaggtgg aaggactgct gcaggccctg      780

acccggaaac tggaagccgt gtccaagcgg ctggccatcc tggaaaacac cgtggtgtcc      840

ggaggcgggg gtagcggcgg agggggctct ggcggtggcg ggtctggagg cgggggttca      900

gaagtgcagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg      960

agctgtgccg ccagcggctt cacctttagc agccacgcca tgagctgggt gcgccaggcc     1020

cctggaaagt gcctggaatg ggtgtccgcc atctgggcca gcggcgagca gtactacgcc     1080

gatagcgtga agggccggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg     1140

cagatgaaca gcctgcgggc cgaggacacc gccgtgtact attgtgccaa gggctggctg     1200

ggcaacttcg actattgggg ccagggcacc ctcgtgaccg tgtctagcgg agggggcgga     1260

agtggtggcg ggggaagcgg cgggggtggc agcggagggg gcggatctga aattgtgctg     1320

acccagagcc ctggcaccct gagcctgtct ccaggcgaaa gagccacact gagctgcaga     1380

gccagccaga gcgtgtccag aagctacctg gcctggtatc agcagaagcc cggacaggcc     1440

cccagactgc tgatcatcgg cgcctctaca agagccaccg gcatccccga tagattcagc     1500

ggctctggca gcggcaccga cttcaccctg accatcagca gactggaacc cgaggacttt     1560

gccgtgtatt actgccagca gggccaagtg atccccccca cctttggctg tggcacaaag     1620

gtggaaatca aa                                                         1632


<210>  226
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (8H9/28H1) Light chain (LC) (pCON184)

<400>  226

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Thr Tyr Ser Arg 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  227
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (8H9/28H1) CMP chain pETR12239

<400>  227

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Trp Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu 
225                 230                 235                 240 


Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg 
                245                 250                 255     


Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val 
            260                 265                 270         


Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Thr Phe Ser Ser His Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Cys Leu Glu Trp Val Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr 
            340                 345                 350         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        355                 360                 365             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    370                 375                 380                 


Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp 
385                 390                 395                 400 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
            420                 425                 430         


Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg 
        435                 440                 445             


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu 
    450                 455                 460                 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ile 
465                 470                 475                 480 


Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
                485                 490                 495     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
            500                 505                 510         


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro Pro Thr 
        515                 520                 525             


Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
    530                 535             


<210>  228
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (1G4/28H1) LC (pCON251)

<400>  228

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser Tyr Ser Met 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  229
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (1G4/28H1)CMP chain (pETR12640)

<400>  229

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Ser Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu 
225                 230                 235                 240 


Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg 
                245                 250                 255     


Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val 
            260                 265                 270         


Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Thr Phe Ser Ser His Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Cys Leu Glu Trp Val Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr 
            340                 345                 350         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        355                 360                 365             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    370                 375                 380                 


Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp 
385                 390                 395                 400 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
            420                 425                 430         


Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg 
        435                 440                 445             


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu 
    450                 455                 460                 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ile 
465                 470                 475                 480 


Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
                485                 490                 495     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
            500                 505                 510         


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro Pro Thr 
        515                 520                 525             


Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
    530                 535             


<210>  230
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (49B4/28H1) LC (pCON323)

<400>  230

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  231
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (49B4/28H1) CMP chain (pETR12899)

<400>  231

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala Cys Glu 
225                 230                 235                 240 


Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu 
                245                 250                 255     


Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn 
            260                 265                 270         


Thr Val Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Thr Phe Ser Ser His Ala Met Ser Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Cys Leu Glu Trp Val Ser Ala Ile Trp Ala Ser Gly Glu 
            340                 345                 350         


Gln Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        355                 360                 365             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    370                 375                 380                 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu Gly Asn Phe Asp 
385                 390                 395                 400 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
    450                 455                 460                 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
465                 470                 475                 480 


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
                485                 490                 495     


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
            500                 505                 510         


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
        515                 520                 525             


Pro Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
    530                 535                 540 


<210>  232
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (21H4/28H1) LC (pETR12026)

<400>  232

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Thr Tyr Pro Val 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  233
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (21H4/28H1) CMP chain (pETR12810)

<400>  233

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Pro Tyr Phe Pro Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys 
225                 230                 235                 240 


Ala Cys Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu 
                245                 250                 255     


Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile 
            260                 265                 270         


Leu Glu Asn Thr Val Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
    290                 295                 300                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
305                 310                 315                 320 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His Ala Met Ser Trp Val 
                325                 330                 335     


Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser Ala Ile Trp Ala 
            340                 345                 350         


Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        355                 360                 365             


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    370                 375                 380                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu Gly 
385                 390                 395                 400 


Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
    450                 455                 460                 


Ser Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
465                 470                 475                 480 


Arg Leu Leu Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp 
                485                 490                 495     


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
            500                 505                 510         


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln 
        515                 520                 525             


Val Ile Pro Pro Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
    530                 535                 540             


<210>  234
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (CLC563/28H1) LC (pCON586)

<400>  234

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  235
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (CLC563/28H1) CMP chain (pETR12898)

<400>  235

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Val Gly Ala Phe Asp Tyr Trp Gly Gln Gly Ala Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu 
225                 230                 235                 240 


Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg 
                245                 250                 255     


Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val 
            260                 265                 270         


Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Thr Phe Ser Ser His Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Cys Leu Glu Trp Val Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr 
            340                 345                 350         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        355                 360                 365             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    370                 375                 380                 


Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp 
385                 390                 395                 400 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 
            420                 425                 430         


Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg 
        435                 440                 445             


Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu 
    450                 455                 460                 


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ile 
465                 470                 475                 480 


Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
                485                 490                 495     


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
            500                 505                 510         


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro Pro Thr 
        515                 520                 525             


Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
    530                 535             


<210>  236
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (20B7/28H1) LC (pCON260)

<400>  236

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Ala Phe Ser Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  237
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3+3 (20B7/28H1) CMP chain (pETR12639)

<400>  237

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asn Tyr Pro Tyr Ser Tyr Trp Gly Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro 
225                 230                 235                 240 


Cys Ala Cys Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu 
                245                 250                 255     


Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala 
            260                 265                 270         


Ile Leu Glu Asn Thr Val Val Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
    290                 295                 300                 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
305                 310                 315                 320 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His Ala Met Ser Trp 
                325                 330                 335     


Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser Ala Ile Trp 
            340                 345                 350         


Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        355                 360                 365             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    370                 375                 380                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu 
385                 390                 395                 400 


Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
    450                 455                 460                 


Val Ser Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
465                 470                 475                 480 


Pro Arg Leu Leu Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
                485                 490                 495     


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            500                 505                 510         


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly 
        515                 520                 525             


Gln Val Ile Pro Pro Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
    530                 535                 540                 


<210>  238
<211>  1626
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 12B3 VHCH1(4-1BB)-CMPtd-scFv (28H1)

<400>  238
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctggagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagatctgaa      300

ttccgtttct acgctgactt cgactactgg ggccaaggga ccaccgtgac cgtctcgagt      360

gctagcacaa agggacctag cgtgttcccc ctggccccca gcagcaagtc tacatctggc      420

ggaacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gctctctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggaaccc      660

aagagctgcg acggcggagg gggatctggc ggcggaggat ccgaggaaga tccttgcgcc      720

tgcgagagcc tcgtgaagtt ccaggccaag gtggaaggac tgctgcaggc cctgacccgg      780

aaactggaag ccgtgtccaa gcggctggcc atcctggaaa acaccgtggt gtccggaggc      840

gggggtagcg gcggaggggg ctctggcggt ggcgggtctg gaggcggggg ttcagaagtg      900

cagctgctgg aatctggcgg cggactggtg cagcctggcg gatctctgag actgagctgt      960

gccgccagcg gcttcacctt tagcagccac gccatgagct gggtgcgcca ggcccctgga     1020

aagtgcctgg aatgggtgtc cgccatctgg gccagcggcg agcagtacta cgccgatagc     1080

gtgaagggcc ggttcaccat cagccgggac aacagcaaga acaccctgta cctgcagatg     1140

aacagcctgc gggccgagga caccgccgtg tactattgtg ccaagggctg gctgggcaac     1200

ttcgactatt ggggccaggg caccctcgtg accgtgtcta gcggaggggg cggaagtggt     1260

ggcgggggaa gcggcggggg tggcagcgga gggggcggat ctgaaattgt gctgacccag     1320

agccctggca ccctgagcct gtctccaggc gaaagagcca cactgagctg cagagccagc     1380

cagagcgtgt ccagaagcta cctggcctgg tatcagcaga agcccggaca ggcccccaga     1440

ctgctgatca tcggcgcctc tacaagagcc accggcatcc ccgatagatt cagcggctct     1500

ggcagcggca ccgacttcac cctgaccatc agcagactgg aacccgagga ctttgccgtg     1560

tattactgcc agcagggcca agtgatcccc cccacctttg gctgtggcac aaaggtggaa     1620

atcaaa                                                                1626


<210>  239
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 12B3 VLCL-Light chain 1 (4-1BB)

<400>  239
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatcattcgt atccgcagac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  240
<211>  1620
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 25G7 VHCH1(4-1BB)-CMPtd-scFv (28H1)

<400>  240
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgacgac      300

ccgtggccgc cgttcgacta ctggggccaa ggaaccctgg tcaccgtctc gagtgctagc      360

acaaagggac ctagcgtgtt ccccctggcc cccagcagca agtctacatc tggcggaaca      420

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactctctga gcagcgtcgt gacagtgccc agcagctctc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga acccaagagc      660

tgcgacggcg gagggggatc tggcggcgga ggatccgagg aagatccttg cgcctgcgag      720

agcctcgtga agttccaggc caaggtggaa ggactgctgc aggccctgac ccggaaactg      780

gaagccgtgt ccaagcggct ggccatcctg gaaaacaccg tggtgtccgg aggcgggggt      840

agcggcggag ggggctctgg cggtggcggg tctggaggcg ggggttcaga agtgcagctg      900

ctggaatctg gcggcggact ggtgcagcct ggcggatctc tgagactgag ctgtgccgcc      960

agcggcttca cctttagcag ccacgccatg agctgggtgc gccaggcccc tggaaagtgc     1020

ctggaatggg tgtccgccat ctgggccagc ggcgagcagt actacgccga tagcgtgaag     1080

ggccggttca ccatcagccg ggacaacagc aagaacaccc tgtacctgca gatgaacagc     1140

ctgcgggccg aggacaccgc cgtgtactat tgtgccaagg gctggctggg caacttcgac     1200

tattggggcc agggcaccct cgtgaccgtg tctagcggag ggggcggaag tggtggcggg     1260

ggaagcggcg ggggtggcag cggagggggc ggatctgaaa ttgtgctgac ccagagccct     1320

ggcaccctga gcctgtctcc aggcgaaaga gccacactga gctgcagagc cagccagagc     1380

gtgtccagaa gctacctggc ctggtatcag cagaagcccg gacaggcccc cagactgctg     1440

atcatcggcg cctctacaag agccaccggc atccccgata gattcagcgg ctctggcagc     1500

ggcaccgact tcaccctgac catcagcaga ctggaacccg aggactttgc cgtgtattac     1560

tgccagcagg gccaagtgat cccccccacc tttggctgtg gcacaaaggt ggaaatcaaa     1620


<210>  241
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 25G7 VLCL-Light chain 1 (4-1BB)

<400>  241
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactccctt gataggcgcg gtatgtgggt attcggcgga      300

gggaccaagc tgaccgtcct aggtcaaccc aaggctgccc ccagcgtgac cctgttcccc      360

cccagcagcg aggaactgca ggccaacaag gccaccctgg tctgcctgat cagcgacttc      420

tacccaggcg ccgtgaccgt ggcctggaag gccgacagca gccccgtgaa ggccggcgtg      480

gagaccacca cccccagcaa gcagagcaac aacaagtacg ccgccagcag ctacctgagc      540

ctgacccccg agcagtggaa gagccacagg tcctacagct gccaggtgac ccacgagggc      600

agcaccgtgg agaaaaccgt ggcccccacc gagtgcagc                             639


<210>  242
<211>  1623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11D5 VHCH1(4-1BB)-CMPtd-scFv (28H1)

<400>  242
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagatctact      300

ctgatctacg gttacttcga ctactggggc caagggacca ccgtgaccgt ctcctcagct      360

agcacaaagg gacctagcgt gttccccctg gcccccagca gcaagtctac atctggcgga      420

acagccgccc tgggctgcct cgtgaaggac tactttcccg agcccgtgac cgtgtcctgg      480

aactctggcg ctctgacaag cggcgtgcac acctttccag ccgtgctgca gagcagcggc      540

ctgtactctc tgagcagcgt cgtgacagtg cccagcagct ctctgggcac ccagacctac      600

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggaacccaag      660

agctgcgacg gcggaggggg atctggcggc ggaggatccg aggaagatcc ttgcgcctgc      720

gagagcctcg tgaagttcca ggccaaggtg gaaggactgc tgcaggccct gacccggaaa      780

ctggaagccg tgtccaagcg gctggccatc ctggaaaaca ccgtggtgtc cggaggcggg      840

ggtagcggcg gagggggctc tggcggtggc gggtctggag gcgggggttc agaagtgcag      900

ctgctggaat ctggcggcgg actggtgcag cctggcggat ctctgagact gagctgtgcc      960

gccagcggct tcacctttag cagccacgcc atgagctggg tgcgccaggc ccctggaaag     1020

tgcctggaat gggtgtccgc catctgggcc agcggcgagc agtactacgc cgatagcgtg     1080

aagggccggt tcaccatcag ccgggacaac agcaagaaca ccctgtacct gcagatgaac     1140

agcctgcggg ccgaggacac cgccgtgtac tattgtgcca agggctggct gggcaacttc     1200

gactattggg gccagggcac cctcgtgacc gtgtctagcg gagggggcgg aagtggtggc     1260

gggggaagcg gcgggggtgg cagcggaggg ggcggatctg aaattgtgct gacccagagc     1320

cctggcaccc tgagcctgtc tccaggcgaa agagccacac tgagctgcag agccagccag     1380

agcgtgtcca gaagctacct ggcctggtat cagcagaagc ccggacaggc ccccagactg     1440

ctgatcatcg gcgcctctac aagagccacc ggcatccccg atagattcag cggctctggc     1500

agcggcaccg acttcaccct gaccatcagc agactggaac ccgaggactt tgccgtgtat     1560

tactgccagc agggccaagt gatccccccc acctttggct gtggcacaaa ggtggaaatc     1620

aaa                                                                   1623


<210>  243
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 11D5 VLCL-Light chain 1 (4-1BB)

<400>  243
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag cttaattcgt atcctcagac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  244
<211>  1626
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 9B11 VHCH1(4-1BB)-CMPtd-scFv (28H1)

<400>  244
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagatcttct      300

ggtgcttacc cgggttactt cgactactgg ggccaaggga ccaccgtgac cgtctcctca      360

gctagcacaa agggacctag cgtgttcccc ctggccccca gcagcaagtc tacatctggc      420

ggaacagccg ccctgggctg cctcgtgaag gactactttc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgctctgac aagcggcgtg cacacctttc cagccgtgct gcagagcagc      540

ggcctgtact ctctgagcag cgtcgtgaca gtgcccagca gctctctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggaaccc      660

aagagctgcg acggcggagg gggatctggc ggcggaggat ccgaggaaga tccttgcgcc      720

tgcgagagcc tcgtgaagtt ccaggccaag gtggaaggac tgctgcaggc cctgacccgg      780

aaactggaag ccgtgtccaa gcggctggcc atcctggaaa acaccgtggt gtccggaggc      840

gggggtagcg gcggaggggg ctctggcggt ggcgggtctg gaggcggggg ttcagaagtg      900

cagctgctgg aatctggcgg cggactggtg cagcctggcg gatctctgag actgagctgt      960

gccgccagcg gcttcacctt tagcagccac gccatgagct gggtgcgcca ggcccctgga     1020

aagtgcctgg aatgggtgtc cgccatctgg gccagcggcg agcagtacta cgccgatagc     1080

gtgaagggcc ggttcaccat cagccgggac aacagcaaga acaccctgta cctgcagatg     1140

aacagcctgc gggccgagga caccgccgtg tactattgtg ccaagggctg gctgggcaac     1200

ttcgactatt ggggccaggg caccctcgtg accgtgtcta gcggaggggg cggaagtggt     1260

ggcgggggaa gcggcggggg tggcagcgga gggggcggat ctgaaattgt gctgacccag     1320

agccctggca ccctgagcct gtctccaggc gaaagagcca cactgagctg cagagccagc     1380

cagagcgtgt ccagaagcta cctggcctgg tatcagcaga agcccggaca ggcccccaga     1440

ctgctgatca tcggcgcctc tacaagagcc accggcatcc ccgatagatt cagcggctct     1500

ggcagcggca ccgacttcac cctgaccatc agcagactgg aacccgagga ctttgccgtg     1560

tattactgcc agcagggcca agtgatcccc cccacctttg gctgtggcac aaaggtggaa     1620

atcaaa                                                                1626


<210>  245
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 9B11 VLCL-Light chain 1 (4-1BB)

<400>  245
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag gttaattctt atccgcagac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  246
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12B3 VHCH1(4-1BB)-CMPtd-scFv (28H1)

<400>  246

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Phe Arg Phe Tyr Ala Asp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala 
225                 230                 235                 240 


Cys Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln 
                245                 250                 255     


Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu 
            260                 265                 270         


Glu Asn Thr Val Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
    290                 295                 300                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
305                 310                 315                 320 


Ala Ala Ser Gly Phe Thr Phe Ser Ser His Ala Met Ser Trp Val Arg 
                325                 330                 335     


Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser Ala Ile Trp Ala Ser 
            340                 345                 350         


Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        355                 360                 365             


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    370                 375                 380                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu Gly Asn 
385                 390                 395                 400 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
    450                 455                 460                 


Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
465                 470                 475                 480 


Leu Leu Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg 
                485                 490                 495     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
            500                 505                 510         


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val 
        515                 520                 525             


Ile Pro Pro Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
    530                 535                 540         


<210>  247
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12B3 VLCL-Light chain 1 (4-1BB)

<400>  247

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  248
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25G7 VHCH1(4-1BB)-CMPtd-scFv (28H1)

<400>  248

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Pro Trp Pro Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala Cys Glu 
225                 230                 235                 240 


Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu 
                245                 250                 255     


Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn 
            260                 265                 270         


Thr Val Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Thr Phe Ser Ser His Ala Met Ser Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Cys Leu Glu Trp Val Ser Ala Ile Trp Ala Ser Gly Glu 
            340                 345                 350         


Gln Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        355                 360                 365             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    370                 375                 380                 


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu Gly Asn Phe Asp 
385                 390                 395                 400 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
    450                 455                 460                 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
465                 470                 475                 480 


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
                485                 490                 495     


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
            500                 505                 510         


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
        515                 520                 525             


Pro Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
    530                 535                 540 


<210>  249
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25G7 VLCL-Light chain 1 (4-1BB)

<400>  249

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Leu Asp Arg Arg Gly Met Trp 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  250
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11D5 VHCH1(4-1BB)-CMPtd-scFv (28H1)

<400>  250

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Leu Ile Tyr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala Cys 
225                 230                 235                 240 


Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala 
                245                 250                 255     


Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu 
            260                 265                 270         


Asn Thr Val Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Thr Phe Ser Ser His Ala Met Ser Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Cys Leu Glu Trp Val Ser Ala Ile Trp Ala Ser Gly 
            340                 345                 350         


Glu Gln Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu Gly Asn Phe 
385                 390                 395                 400 


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            420                 425                 430         


Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg 
    450                 455                 460                 


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe 
                485                 490                 495     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
            500                 505                 510         


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile 
        515                 520                 525             


Pro Pro Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
    530                 535                 540     


<210>  251
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11D5 VLCL-Light chain 1 (4-1BB)

<400>  251

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  252
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9B11 VHCH1(4-1BB)-CMPtd-scFv (28H1)

<400>  252

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Gly Ala Tyr Pro Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Glu Asp Pro Cys Ala 
225                 230                 235                 240 


Cys Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln 
                245                 250                 255     


Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu 
            260                 265                 270         


Glu Asn Thr Val Val Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
    290                 295                 300                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
305                 310                 315                 320 


Ala Ala Ser Gly Phe Thr Phe Ser Ser His Ala Met Ser Trp Val Arg 
                325                 330                 335     


Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser Ala Ile Trp Ala Ser 
            340                 345                 350         


Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        355                 360                 365             


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    370                 375                 380                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Trp Leu Gly Asn 
385                 390                 395                 400 


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
    450                 455                 460                 


Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
465                 470                 475                 480 


Leu Leu Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg 
                485                 490                 495     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
            500                 505                 510         


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val 
        515                 520                 525             


Ile Pro Pro Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
    530                 535                 540         


<210>  253
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9B11 VLCL-Light chain 1 (4-1BB)

<400>  253

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asn Ser Tyr Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


