                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Bispecific antigen binding molecule for a costimulatory TNF 
       receptor

<130>  P34211-WO

<150>  EP17163639
<151>  2017-03-29

<160>  193   

<170>  PatentIn version 3.5

<210>  1
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala 
            180                 185     


<210>  2
<211>  192
<212>  PRT
<213>  Mus musculus

<400>  2

Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr Pro Ser Gly 
1               5                   10                  15      


His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met Val Ser Arg 
            20                  25                  30          


Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu Thr Gly Phe 
        35                  40                  45              


Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys Thr Gln Cys 
    50                  55                  60                  


Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr Pro Thr Gln 
65                  70                  75                  80  


Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg Gln Asp Ser 
                85                  90                  95      


Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro Gly His Phe 
            100                 105                 110         


Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu 
        115                 120                 125             


Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu Asp Ala Val 
    130                 135                 140                 


Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu Thr Gln Arg 
145                 150                 155                 160 


Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val Trp Pro Arg 
                165                 170                 175     


Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro Glu Gly Pro 
            180                 185                 190         


<210>  3
<211>  186
<212>  PRT
<213>  cynomolgus

<400>  3

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys Gln 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Asn Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ala Lys Pro Cys Lys Ala Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Pro Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Pro Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Thr Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Arg Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Arg Gly Pro Ala 
            180                 185     


<210>  4
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-H1

<400>  4

Ser Tyr Ala Ile Ser 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC-564, 17A9)  CDR-H1

<400>  5

Ser Tyr Ala Met Ser 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-H2

<400>  6

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC-564, 17A9)  CDR-H2

<400>  7

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  CDR-H3

<400>  8

Glu Tyr Gly Trp Met Asp Tyr 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  CDR-H3

<400>  9

Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr 
1               5                   


<210>  10
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  CDR-H3

<400>  10

Glu Tyr Gly Ser Met Asp Tyr 
1               5           


<210>  11
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  CDR-H3

<400>  11

Val Asn Tyr Pro Tyr Ser Tyr Trp Gly Asp Phe Asp Tyr 
1               5                   10              


<210>  12
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563)  CDR-H3

<400>  12

Asp Val Gly Ala Phe Asp Tyr 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-564)  CDR-H3

<400>  13

Asp Val Gly Pro Phe Asp Tyr 
1               5           


<210>  14
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9)-CDR-H3

<400>  14

Val Phe Tyr Arg Gly Gly Val Ser Met Asp Tyr 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-L1

<400>  15

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  16
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC564)  CDR-L1

<400>  16

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  17
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9) CDR-L1

<400>  17

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  18
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9,49B4,1G4, 20B7)  CDR-L2

<400>  18

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC564)  CDR-L2

<400>  19

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9) CDR-L2

<400>  20

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  21
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  CDR-L3

<400>  21

Gln Gln Tyr Leu Thr Tyr Ser Arg Phe Thr 
1               5                   10  


<210>  22
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  CDR-L3

<400>  22

Gln Gln Tyr Ser Ser Gln Pro Tyr Thr 
1               5                   


<210>  23
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  CDR-L3

<400>  23

Gln Gln Tyr Ile Ser Tyr Ser Met Leu Thr 
1               5                   10  


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  CDR-L3

<400>  24

Gln Gln Tyr Gln Ala Phe Ser Leu Thr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563, CLC-164)  CDR-L3

<400>  25

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  26
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9) CDR-L3

<400>  26

Asn Ser Arg Val Met Pro His Asn Arg Val 
1               5                   10  


<210>  27
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  27

Gly Tyr Asn Leu His 
1               5   


<210>  28
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  28

Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr Asn Ser Val Leu Lys Ser 
1               5                   10                  15      


<210>  29
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  29

Asp Gly Arg Gly Asp Ser Phe Asp Tyr 
1               5                   


<210>  30
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  30

Arg Ser Ser Gln Ser Leu Val Tyr Lys Asp Gly Gln Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  31
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  31

Trp Met Ser Thr Arg Ala Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  32

Gln Gln Val Arg Glu Tyr Pro Phe Thr 
1               5                   


<210>  33
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  VH

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Trp Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  34
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(8H9)  VL

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Thr Tyr Ser Arg 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  35
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  VH

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  36
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(49B4)  VL

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  37
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  VH

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Ser Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  38
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(1G4)  VL

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser Tyr Ser Met 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  39
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  VH

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asn Tyr Pro Tyr Ser Tyr Trp Gly Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  40
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(20B7)  VL

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Ala Phe Ser Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563)  VH

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Val Gly Ala Phe Asp Tyr Trp Gly Gln Gly Ala Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  42
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-563)  VL

<400>  42

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  43
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-564)  VH

<400>  43

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Asp Val Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  44
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(CLC-564)  VL

<400>  44

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  45
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9)  VH

<400>  45

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Phe Tyr Arg Gly Gly Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  46
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40(17A9)  VL

<400>  46

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Val Met Pro His Asn Arg 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105     


<210>  47
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muOX40(OX86) VH

<400>  47

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Asn Leu His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muOX40(OX86) VL

<400>  48

Asp Ile Val Met Thr Gln Gly Ala Leu Pro Asn Pro Val Pro Ser Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Thr Cys Arg Ser Ser Gln Ser Leu Val Tyr Lys 
            20                  25                  30          


Asp Gly Gln Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Thr Tyr Trp Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Arg Ala Glu Asp Ala Gly Val Tyr Tyr Cys Gln Gln Val 
                85                  90                  95      


Arg Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  49
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Glu Glu Cys Val Cys Glu Asn Tyr Lys Leu Ala Val Asn Cys Phe 
1               5                   10                  15      


Val Asn Asn Asn Arg Gln Cys Gln Cys Thr Ser Val Gly Ala Gln Asn 
            20                  25                  30          


Thr Val Ile Cys Ser Lys Leu Ala Ala Lys Cys Leu Val Met Lys Ala 
        35                  40                  45              


Glu Met Asn Gly Ser Lys Leu Gly Arg Arg Ala Lys Pro Glu Gly Ala 
    50                  55                  60                  


Leu Gln Asn Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Glu Ser Gly 
65                  70                  75                  80  


Leu Phe Lys Ala Lys Gln Cys Asn Gly Thr Ser Met Cys Trp Cys Val 
                85                  90                  95      


Asn Thr Ala Gly Val Arg Arg Thr Asp Lys Asp Thr Glu Ile Thr Cys 
            100                 105                 110         


Ser Glu Arg Val Arg Thr Tyr Trp Ile Ile Ile Glu Leu Lys His Lys 
        115                 120                 125             


Ala Arg Glu Lys Pro Tyr Asp Ser Lys Ser Leu Arg Thr Ala Leu Gln 
    130                 135                 140                 


Lys Glu Ile Thr Thr Arg Tyr Gln Leu Asp Pro Lys Phe Ile Thr Ser 
145                 150                 155                 160 


Ile Leu Tyr Glu Asn Asn Val Ile Thr Ile Asp Leu Val Gln Asn Ser 
                165                 170                 175     


Ser Gln Lys Thr Gln Asn Asp Val Asp Ile Ala Asp Val Ala Tyr Tyr 
            180                 185                 190         


Phe Glu Lys Asp Val Lys Gly Glu Ser Leu Phe His Ser Lys Lys Met 
        195                 200                 205             


Asp Leu Thr Val Asn Gly Glu Gln Leu Asp Leu Asp Pro Gly Gln Thr 
    210                 215                 220                 


Leu Ile Tyr Tyr Val Asp Glu Lys Ala Pro Glu Phe Ser Met Gln Gly 
225                 230                 235                 240 


Leu Lys 
        


<210>  50
<211>  243
<212>  PRT
<213>  Mus musculus

<400>  50

Gln Arg Asp Cys Val Cys Asp Asn Tyr Lys Leu Ala Thr Ser Cys Ser 
1               5                   10                  15      


Leu Asn Glu Tyr Gly Glu Cys Gln Cys Thr Ser Tyr Gly Thr Gln Asn 
            20                  25                  30          


Thr Val Ile Cys Ser Lys Leu Ala Ser Lys Cys Leu Ala Met Lys Ala 
        35                  40                  45              


Glu Met Thr His Ser Lys Ser Gly Arg Arg Ile Lys Pro Glu Gly Ala 
    50                  55                  60                  


Ile Gln Asn Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Glu Gln Gly 
65                  70                  75                  80  


Leu Phe Lys Ala Lys Gln Cys Asn Gly Thr Ala Thr Cys Trp Cys Val 
                85                  90                  95      


Asn Thr Ala Gly Val Arg Arg Thr Asp Lys Asp Thr Glu Ile Thr Cys 
            100                 105                 110         


Ser Glu Arg Val Arg Thr Tyr Trp Ile Ile Ile Glu Leu Lys His Lys 
        115                 120                 125             


Glu Arg Glu Ser Pro Tyr Asp His Gln Ser Leu Gln Thr Ala Leu Gln 
    130                 135                 140                 


Glu Ala Phe Thr Ser Arg Tyr Lys Leu Asn Gln Lys Phe Ile Lys Asn 
145                 150                 155                 160 


Ile Met Tyr Glu Asn Asn Val Ile Thr Ile Asp Leu Met Gln Asn Ser 
                165                 170                 175     


Ser Gln Lys Thr Gln Asp Asp Val Asp Ile Ala Asp Val Ala Tyr Tyr 
            180                 185                 190         


Phe Glu Lys Asp Val Lys Gly Glu Ser Leu Phe His Ser Ser Lys Ser 
        195                 200                 205             


Met Asp Leu Arg Val Asn Gly Glu Pro Leu Asp Leu Asp Pro Gly Gln 
    210                 215                 220                 


Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala Pro Glu Phe Ser Met Gln 
225                 230                 235                 240 


Gly Leu Thr 
            


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpCAM(3-17I)  CDR-H1

<400>  51

Ser Tyr Ala Ile Ser 
1               5   


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpCAM(3-17I)  CDR-H2

<400>  52

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpCAM(3-17I)  CDR-H3

<400>  53

Gly Leu Leu Trp 
1               


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpCAM(3-17I)  CDR-L1

<400>  54

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpCAM(3-17I)  CDR-L2

<400>  55

Gly Ala Ser Thr Thr Ala Ser 
1               5           


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpCAM(3-17I)  CDR-L3

<400>  56

Gln Gln Tyr Asn Asn Trp Pro Pro Ala Tyr Thr 
1               5                   10      


<210>  57
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  57

Asn Phe Pro Met Ala 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  58

Thr Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  59

Thr Leu Tyr Ile Leu Arg Val Phe Tyr Phe 
1               5                   10  


<210>  60
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  60

Leu Ala Ser Glu Gly Ile Ser Asn Asp Leu Ala 
1               5                   10      


<210>  61
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  61

Ala Thr Ser Arg Leu Gln Asp 
1               5           


<210>  62
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  62

Gln Gln Ser Tyr Lys Tyr Pro Trp Thr 
1               5                   


<210>  63
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpCAM(3-17I) VH

<400>  63

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Leu Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  64
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EpCAM(3-17I) VL

<400>  64

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Thr Ala Ser Gly Ile Pro Ala Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Ala Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  65
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muEpCAM(G8.8) VH

<400>  65

Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Thr Leu Tyr Ile Leu Arg Val Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120     


<210>  66
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  muEpCAM(G8.8) VL

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Gly Ile Ser Asn Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Tyr Ser Leu Lys Ile Ser Gly Met Gln Pro 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Phe Cys Gln Gln Ser Tyr Lys Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  67
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  68
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Met Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  69
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  70
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  71
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  72
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  73
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  74
<211>  272
<212>  PRT
<213>  Mus musculus

<400>  74

Met Tyr Val Trp Val Gln Gln Pro Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Thr Leu Gly Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr 
            20                  25                  30          


Pro Ser Gly His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met 
        35                  40                  45              


Val Ser Arg Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu 
    50                  55                  60                  


Thr Gly Phe Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys 
65                  70                  75                  80  


Thr Gln Cys Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr 
                85                  90                  95      


Pro Thr Gln Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg 
            100                 105                 110         


Gln Asp Ser Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro 
        115                 120                 125             


Gly His Phe Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn 
    130                 135                 140                 


Cys Thr Leu Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu 
145                 150                 155                 160 


Asp Ala Val Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu 
                165                 170                 175     


Thr Gln Arg Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val 
            180                 185                 190         


Trp Pro Arg Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro 
        195                 200                 205             


Glu Gly Pro Ala Phe Ala Val Leu Leu Gly Leu Gly Leu Gly Leu Leu 
    210                 215                 220                 


Ala Pro Leu Thr Val Leu Leu Ala Leu Tyr Leu Leu Arg Lys Ala Trp 
225                 230                 235                 240 


Arg Leu Pro Asn Thr Pro Lys Pro Cys Trp Gly Asn Ser Phe Arg Thr 
                245                 250                 255     


Pro Ile Gln Glu Glu His Thr Asp Ala His Phe Thr Leu Ala Lys Ile 
            260                 265                 270         


<210>  75
<211>  315
<212>  PRT
<213>  Mus musculus

<400>  75

Met Ala Gly Pro Gln Ala Leu Ala Phe Gly Leu Leu Leu Ala Val Val 
1               5                   10                  15      


Thr Ala Thr Leu Ala Ala Ala Gln Arg Asp Cys Val Cys Asp Asn Tyr 
            20                  25                  30          


Lys Leu Ala Thr Ser Cys Ser Leu Asn Glu Tyr Gly Glu Cys Gln Cys 
        35                  40                  45              


Thr Ser Tyr Gly Thr Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ser 
    50                  55                  60                  


Lys Cys Leu Ala Met Lys Ala Glu Met Thr His Ser Lys Ser Gly Arg 
65                  70                  75                  80  


Arg Ile Lys Pro Glu Gly Ala Ile Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Gln Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ala Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Glu Arg Glu Ser Pro Tyr Asp His Gln 
145                 150                 155                 160 


Ser Leu Gln Thr Ala Leu Gln Glu Ala Phe Thr Ser Arg Tyr Lys Leu 
                165                 170                 175     


Asn Gln Lys Phe Ile Lys Asn Ile Met Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Met Gln Asn Ser Ser Gln Lys Thr Gln Asp Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Ser Lys Ser Met Asp Leu Arg Val Asn Gly Glu Pro 
225                 230                 235                 240 


Leu Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys 
                245                 250                 255     


Ala Pro Glu Phe Ser Met Gln Gly Leu Thr Ala Gly Ile Ile Ala Val 
            260                 265                 270         


Ile Val Val Val Ser Leu Ala Val Ile Ala Gly Ile Val Val Leu Val 
        275                 280                 285             


Ile Ser Thr Arg Lys Lys Ser Ala Lys Tyr Glu Lys Ala Glu Ile Lys 
    290                 295                 300                 


Glu Met Gly Glu Ile His Arg Glu Leu Asn Ala 
305                 310                 315 


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Petpide linker G4S

<400>  76

Gly Gly Gly Gly Ser 
1               5   


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (G4S)2

<400>  77

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (SG4)2

<400>  78

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (G4S)3

<400>  79

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  80
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker G4(SG4)2

<400>  80

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  81
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker (G4S)4

<400>  81

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GSPGSSSSGS

<400>  82

Gly Ser Pro Gly Ser Ser Ser Ser Gly Ser 
1               5                   10  


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GSGSGSGS

<400>  83

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GSGSGNGS

<400>  84

Gly Ser Gly Ser Gly Asn Gly Ser 
1               5               


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGSGSGSG

<400>  85

Gly Gly Ser Gly Ser Gly Ser Gly 
1               5               


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGSGSG

<400>  86

Gly Gly Ser Gly Ser Gly 
1               5       


<210>  87
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linkeer GGSG

<400>  87

Gly Gly Ser Gly 
1               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGSGNGSG

<400>  88

Gly Gly Ser Gly Asn Gly Ser Gly 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGNGSGSG

<400>  89

Gly Gly Asn Gly Ser Gly Ser Gly 
1               5               


<210>  90
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker GGNGSG

<400>  90

Gly Gly Asn Gly Ser Gly 
1               5       


<210>  91
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Fc hole chain

<400>  91
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  92
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence human OX40 antigen Fc knob chain

<400>  92
ctgcactgcg tgggcgacac ctaccccagc aacgaccggt gctgccacga gtgcagaccc       60

ggcaacggca tggtgtcccg gtgcagccgg tcccagaaca ccgtgtgcag accttgcggc      120

cctggcttct acaacgacgt ggtgtccagc aagccctgca agccttgtac ctggtgcaac      180

ctgcggagcg gcagcgagcg gaagcagctg tgtaccgcca cccaggatac cgtgtgccgg      240

tgtagagccg gcacccagcc cctggacagc tacaaacccg gcgtggactg cgccccttgc      300

cctcctggcc acttcagccc tggcgacaac caggcctgca agccttggac caactgcacc      360

ctggccggca agcacaccct gcagcccgcc agcaatagca gcgacgccat ctgcgaggac      420

cgggatcctc ctgccaccca gcctcaggaa acccagggcc ctcccgccag acccatcacc      480

gtgcagccta cagaggcctg gcccagaacc agccaggggc ctagcaccag acccgtggaa      540

gtgcctggcg gcagagccgt cgacgaacag ttatattttc agggcggctc acccaaatct      600

gcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      660

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      720

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      780

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      840

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      900

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      960

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgccggga tgagctgacc     1020

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1080

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1140

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1200

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1260

agcctctccc tgtctccggg taaatccgga ggcctgaacg acatcttcga ggcccagaag     1320

attgaatggc acgag                                                      1335


<210>  93
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence cynomolgus OX40 antigen Fc knob chain

<400>  93
ctccactgtg tcggggacac ctaccccagc aacgaccggt gctgtcagga gtgcaggcca       60

ggcaacggga tggtgagccg ctgcaaccgc tcccagaaca cggtgtgccg tccgtgcggg      120

cccggcttct acaacgacgt ggtcagcgcc aagccctgca aggcctgcac atggtgcaac      180

ctcagaagtg ggagtgagcg gaaacagccg tgcacggcca cacaggacac agtctgccgc      240

tgccgggcgg gcacccagcc cctggacagc tacaagcctg gagttgactg tgccccctgc      300

cctccagggc acttctcccc gggcgacaac caggcctgca agccctggac caactgcacc      360

ttggccggga agcacaccct gcagccagcc agcaatagct cggacgccat ctgtgaggac      420

agggaccccc cacccacaca gccccaggag acccagggcc ccccggccag gcccaccact      480

gtccagccca ctgaagcctg gcccagaacc tcacagagac cctccacccg gcccgtggag      540

gtccccaggg gccctgcggt cgacgaacag ttatattttc agggcggctc acccaaatct      600

gcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      660

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      720

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      780

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      840

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      900

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      960

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgccggga tgagctgacc     1020

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1080

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1140

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1200

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1260

agcctctccc tgtctccggg taaatccgga ggcctgaacg acatcttcga ggcccagaag     1320

attgaatggc acgag                                                      1335


<210>  94
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence murine OX40 antigen Fc knob chain

<400>  94
gtgaccgcca gacggctgaa ctgcgtgaag cacacctacc ccagcggcca caagtgctgc       60

agagagtgcc agcccggcca cggcatggtg tccagatgcg accacacacg ggacaccctg      120

tgccaccctt gcgagacagg cttctacaac gaggccgtga actacgatac ctgcaagcag      180

tgcacccagt gcaaccacag aagcggcagc gagctgaagc agaactgcac ccccacccag      240

gataccgtgt gcagatgcag acccggcacc cagcccagac aggacagcgg ctacaagctg      300

ggcgtggact gcgtgccctg ccctcctggc cacttcagcc ccggcaacaa ccaggcctgc      360

aagccctgga ccaactgcac cctgagcggc aagcagacca gacaccccgc cagcgacagc      420

ctggatgccg tgtgcgagga cagaagcctg ctggccaccc tgctgtggga gacacagcgg      480

cccaccttca gacccaccac cgtgcagagc accaccgtgt ggcccagaac cagcgagctg      540

cccagtcctc ctaccctcgt gacacctgag ggccccgtcg acgaacagtt atattttcag      600

ggcggctcac ccaaatctgc agacaaaact cacacatgcc caccgtgccc agcacctgaa      660

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      720

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      780

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      840

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      900

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      960

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1020

tgccgggatg agctgaccaa gaaccaggtc agcctgtggt gcctggtcaa aggcttctat     1080

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1140

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1200

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1260

aaccactaca cgcagaagag cctctccctg tctccgggta aatccggagg cctgaacgac     1320

atcttcgagg cccagaagat tgaatggcac gag                                  1353


<210>  95
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc hole chain

<400>  95

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  96
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human OX40 antigen Fc knob chain

<400>  96

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Asp Glu Gln Leu Tyr 
            180                 185                 190         


Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro 
        195                 200                 205             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                245                 250                 255     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            260                 265                 270         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        275                 280                 285             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    290                 295                 300                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
305                 310                 315                 320 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                325                 330                 335     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            340                 345                 350         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        355                 360                 365             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    370                 375                 380                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
385                 390                 395                 400 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                405                 410                 415     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu 
            420                 425                 430         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        435                 440                 445 


<210>  97
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus OX40 antigen Fc knob chain

<400>  97

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys Gln 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Asn Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ala Lys Pro Cys Lys Ala Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Pro Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Pro Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Thr Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Arg Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Arg Gly Pro Ala Val Asp Glu Gln Leu Tyr 
            180                 185                 190         


Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro 
        195                 200                 205             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                245                 250                 255     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            260                 265                 270         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        275                 280                 285             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    290                 295                 300                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
305                 310                 315                 320 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                325                 330                 335     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            340                 345                 350         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        355                 360                 365             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    370                 375                 380                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
385                 390                 395                 400 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                405                 410                 415     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu 
            420                 425                 430         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        435                 440                 445 


<210>  98
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine OX40 antigen Fc knob chain

<400>  98

Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr Pro Ser Gly 
1               5                   10                  15      


His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met Val Ser Arg 
            20                  25                  30          


Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu Thr Gly Phe 
        35                  40                  45              


Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys Thr Gln Cys 
    50                  55                  60                  


Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr Pro Thr Gln 
65                  70                  75                  80  


Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg Gln Asp Ser 
                85                  90                  95      


Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro Gly His Phe 
            100                 105                 110         


Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu 
        115                 120                 125             


Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu Asp Ala Val 
    130                 135                 140                 


Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu Thr Gln Arg 
145                 150                 155                 160 


Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val Trp Pro Arg 
                165                 170                 175     


Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro Glu Gly Pro 
            180                 185                 190         


Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp 
        195                 200                 205             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                245                 250                 255     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            260                 265                 270         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    290                 295                 300                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        355                 360                 365             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
        435                 440                 445             


Trp His Glu 
    450     


<210>  99
<211>  1613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of library DP88-4

<400>  99
tgaaatacct attgcctacg gcagccgctg gattgttatt actcgcggcc cagccggcca       60

tggccgacat ccagatgacc cagtctcctt ccaccctgtc tgcatctgta ggagaccgtg      120

tcaccatcac ttgccgtgcc agtcagagta ttagtagctg gttggcctgg tatcagcaga      180

aaccagggaa agcccctaag ctcctgatct atgatgcctc cagtttggaa agtggggtcc      240

catcacgttt cagcggcagt ggatccggga cagaattcac tctcaccatc agcagcttgc      300

agcctgatga ttttgcaact tattactgcc aacagtataa tagttattct acgtttggcc      360

agggcaccaa agtcgagatc aagcgtacgg tggctgcacc atctgtcttc atcttcccgc      420

catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg aataacttct      480

atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg ggtaactccc      540

aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc agcaccctga      600

cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc acccatcagg      660

gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggagcc gcagaacaaa      720

aactcatctc agaagaggat ctgaatggag ccgcagacta caaggacgac gacgacaagg      780

gtgccgcata ataaggcgcg ccaattctat ttcaaggaga cagtcatatg aaatacctgc      840

tgccgaccgc tgctgctggt ctgctgctcc tcgctgccca gccggcgatg gcccaggtgc      900

aattggtgca gtctggggct gaggtgaaga agcctgggtc ctcggtgaag gtctcctgca      960

aggcctccgg aggcacattc agcagctacg ctataagctg ggtgcgacag gcccctggac     1020

aagggctcga gtggatggga gggatcatcc ctatctttgg tacagcaaac tacgcacaga     1080

agttccaggg cagggtcacc attactgcag acaaatccac gagcacagcc tacatggagc     1140

tgagcagcct gagatctgag gacaccgccg tgtattactg tgcgagacta tccccaggcg     1200

gttactatgt tatggatgcc tggggccaag ggaccaccgt gaccgtctcc tcagctagca     1260

ccaaaggccc atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag     1320

cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg tcgtggaact     1380

caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc tcaggactct     1440

actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag acctacatct     1500

gcaacgtgaa tcacaagccc agcaacacca aagtggacaa gaaagttgag cccaaatctt     1560

gtgacgcggc cgcaagcact agtgcccatc accatcacca tcacgccgcg gca            1613


<210>  100
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of Fab light chain Vk1_5

<400>  100
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt attctacgtt tggccagggc      300

accaaagtcg agatcaagcg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtg gagccgcaga acaaaaactc      660

atctcagaag aggatctgaa tggagccgca gactacaagg acgacgacga caagggtgcc      720

gca                                                                    723


<210>  101
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vk1_5

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu 
    210                 215                 220                 


Asp Leu Asn Gly Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala 
225                 230                 235                 240 


Ala 
    


<210>  102
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of Fab heavy chain VH1_69

<400>  102
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagactatcc      300

ccaggcggtt actatgttat ggatgcctgg ggccaaggga ccaccgtgac cgtctcctca      360

gctagcacca aaggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaaag tggacaagaa agttgagccc      660

aaatcttgtg acgcggccgc aagcactagt gcccatcacc atcaccatca cgccgcggca      720


<210>  103
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab heavy chain VH1_69

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Pro Gly Gly Tyr Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Ala Ala Ala Ser Thr Ser Ala His His His His His His Ala Ala Ala 
225                 230                 235                 240 


<210>  104
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMB3 Primer

<400>  104
caggaaacag ctatgaccat gattac                                            26


<210>  105
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk1_5_L3r_S Primer

<400>  105
ctcgactttg gtgccctggc caaacgtsba atacgaatta tactgttggc agtaataagt       60

tgcaaaatca t                                                            71


<210>  106
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk1_5_L3r_SY Primer

<400>  106
ctcgactttg gtgccctggc caaacgtmhr sgratacgaa ttatactgtt ggcagtaata       60

agttgcaaaa tcat                                                         74


<210>  107
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vk1_5_L3r_SPY

<400>  107
ctcgactttg gtgccctggc caaacgtmhh msssgratac gaattatact gttggcagta       60

ataagttgca aaatcat                                                      77


<210>  108
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH31 Primer

<400>  108
acgtttggcc agggcaccaa agtcgag                                           27


<210>  109
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH32 Primer

<400>  109
tctcgcacag taatacacgg cggtgtcc                                          28


<210>  110
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP88-v4-4

<400>  110
ggacaccgcc gtgtattact gtgcgagaga ctactggggc caagggacca ccgtgaccgt       60

ctcc                                                                    64


<210>  111
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP88-v4-6

<400>  111
ggacaccgcc gtgtattact gtgcgagaga ctactggggc caagggacca ccgtgaccgt       60

ctcc                                                                    64


<210>  112
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP88-v4-8

<400>  112
ggacaccgcc gtgtattact gtgcgagaga ctactggggc caagggacca ccgtgaccgt       60

ctcc                                                                    64


<210>  113
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fdseqlong Primer

<400>  113
gacgttagta aatgaatttt ctgtatgagg                                        30


<210>  114
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (Vk3_20/VH3_23) template

<400>  114
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggccgaaa tcgtgttaac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga      120

gccaccctct cttgcagggc cagtcagagt gttagcagca gctacttagc ctggtaccag      180

cagaaacctg gccaggctcc caggctcctc atctatggag catccagcag ggccactggc      240

atcccagaca ggttcagtgg cagtggatcc gggacagact tcactctcac catcagcaga      300

ctggagcctg aagattttgc agtgtattac tgtcagcagt atggtagctc accgctgacg      360

ttcggccagg ggaccaaagt ggaaatcaaa cgtacggtgg ctgcaccatc tgtcttcatc      420

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      480

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      540

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      600

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      660

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg tggagccgca      720

catcaccatc accatcacgg agccgcagac tacaaggacg acgacgacaa gggtgccgca      780

taataaggcg cgccaattct atttcaagga gacagtcata tgaaatacct gctgccgacc      840

gctgctgctg gtctgctgct cctcgctgcc cagccggcga tggccgaggt gcaattgctg      900

gagtctgggg gaggcttggt acagcctggg gggtccctga gactctcctg tgcagcctcc      960

ggattcacct ttagcagtta tgccatgagc tgggtccgcc aggctccagg gaaggggctg     1020

gagtgggtct cagctattag tggtagtggt ggtagcacat actacgcaga ctccgtgaag     1080

ggccggttca ccatctccag agacaattcc aagaacacgc tgtatctgca gatgaacagc     1140

ctgagagccg aggacacggc cgtatattac tgtgcgaaac cgtttccgta ttttgactac     1200

tggggccaag gaaccctggt caccgtctcg agtgctagca ccaaaggccc atcggtcttc     1260

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc     1320

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc     1380

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg     1440

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc     1500

agcaacacca aagtggacaa gaaagttgag cccaaatctt gtgacgcggc cgcagaacaa     1560

aaactcatct cagaagagga tctgaatgcc gcggca                               1596


<210>  115
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vk3_20

<400>  115
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct gacgttcggc      300

caggggacca aagtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagc cgcacatcac      660

catcaccatc acggagccgc agactacaag gacgacgacg acaagggtgc cgca            714


<210>  116
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vk3_20

<400>  116

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Gly Ala Ala His His His His His His 
    210                 215                 220                 


Gly Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala Ala 
225                 230                 235             


<210>  117
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab heavy chain VH3_23

<400>  117
gaggtgcaat tgctggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaccgttt      300

ccgtattttg actactgggg ccaaggaacc ctggtcaccg tctcgagtgc tagcaccaaa      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaagtg gacaagaaag ttgagcccaa atcttgtgac      660

gcggccgcag aacaaaaact catctcagaa gaggatctga atgccgcggc a               711


<210>  118
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab heavy chain VH3_23 (DP47)

<400>  118

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ala Ala Ala Glu 
    210                 215                 220                 


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ala Ala Ala 
225                 230                 235         


<210>  119
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS64 Primer

<400>  119
acgttcggcc aggggaccaa agtgg                                             25


<210>  120
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47CDR3_ba Primer

<400>  120
cgcacagtaa tatacggccg tgtcc                                             25


<210>  121
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47-v4-4

<400>  121
cgaggacacg gccgtatatt actgtgcgga ctactggggc caaggaaccc tggtcaccgt       60

ctcg                                                                    64


<210>  122
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47-v4-6

<400>  122
cgaggacacg gccgtatatt actgtgcgga ctactggggc caaggaaccc tggtcaccgt       60

ctcg                                                                    64


<210>  123
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DP47-v4-8

<400>  123
cgaggacacg gccgtatatt actgtgcgga ctactggggc caaggaaccc tggtcaccgt       60

ctcg                                                                    64


<210>  124
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fdseqlong

<400>  124
gacgttagta aatgaatttt ctgtatgagg                                        30


<210>  125
<211>  1605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl3_19/VH3_23 library template

<400>  125
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcggc ccagccggcc       60

atggcctcgt ctgagctgac tcaggaccct gctgtgtctg tggccttggg acagacagtc      120

aggatcacat gccaaggaga cagcctcaga agttattatg caagctggta ccagcagaag      180

ccaggacagg cccctgtact tgtcatctat ggtaaaaaca accggccctc agggatccca      240

gaccgattct ctggctccag ctcaggaaac acagcttcct tgaccatcac tggggctcag      300

gcggaagatg aggctgacta ttactgtaac tcccgtgata gtagcggtaa tcatgtggta      360

ttcggcggag ggaccaagct gaccgtccta ggacaaccca aggctgcccc cagcgtgacc      420

ctgttccccc ccagcagcga ggaattgcag gccaacaagg ccaccctggt ctgcctgatc      480

agcgacttct acccaggcgc cgtgaccgtg gcctggaagg ccgacagcag ccccgtgaag      540

gccggcgtgg agaccaccac ccccagcaag cagagcaaca acaagtacgc cgccagcagc      600

tacctgagcc tgacccccga gcagtggaag agccacaggt cctacagctg ccaggtgacc      660

cacgagggca gcaccgtgga gaaaaccgtg gcccccaccg agtgcagcgg agccgcagaa      720

caaaaactca tctcagaaga ggatctgaat ggagccgcag actacaagga cgacgacgac      780

aagggtgccg cataataagg cgcgccaatt ctatttcaag gagacagtca tatgaaatac      840

ctgctgccga ccgctgctgc tggtctgctg ctcctcgctg cccagccggc gatggccgag      900

gtgcaattgc tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc      960

tgtgcagcct ccggattcac ctttagcagt tatgccatga gctgggtccg ccaggctcca     1020

gggaaggggc tggagtgggt ctcagctatt agtggtagtg gtggtagcac atactacgca     1080

gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg     1140

cagatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgaa accgtttccg     1200

tattttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaaaggc     1260

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg     1320

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc     1380

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc     1440

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg     1500

aatcacaagc ccagcaacac caaagtggac aagaaagttg agcccaaatc ttgtgacgcg     1560

gccgcaagca ctagtgccca tcaccatcac catcacgccg cggca                     1605


<210>  126
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vl3_19

<400>  126
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gatagtagcg gtaatcatgt ggtattcggc      300

ggagggacca agctgaccgt cctaggacaa cccaaggctg cccccagcgt gaccctgttc      360

ccccccagca gcgaggaatt gcaggccaac aaggccaccc tggtctgcct gatcagcgac      420

ttctacccag gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacca ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac aggtcctaca gctgccaggt gacccacgag      600

ggcagcaccg tggagaaaac cgtggccccc accgagtgca gcggagccgc agaacaaaaa      660

ctcatctcag aagaggatct gaatggagcc gcagactaca aggacgacga cgacaagggt      720

gccgca                                                                 726


<210>  127
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fab light chain Vl3_19

<400>  127

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu 
    210                 215                 220                 


Glu Asp Leu Asn Gly Ala Ala Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
225                 230                 235                 240 


Ala Ala 
        


<210>  128
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMB3 lambda-DP47 library

<400>  128
caggaaacag ctatgaccat gattac                                            26


<210>  129
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl_3_19_L3r_V lambda-DP47 library

<400>  129
ggacggtcag cttggtccct ccgccgaata cvhvattacc gctactatca cgggagttac       60

agtaatagtc agcctcatct tccgc                                             85


<210>  130
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl_3_19_L3r_HV lambda-DP47

<400>  130
ggacggtcag cttggtccct ccgccgaata ccmmatgatt accgctacta tcacgggagt       60

tacagtaata gtcagcctca tcttccgc                                          88


<210>  131
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Vl_3_19_L3r_HLV lambda-DP47

<400>  131
ggacggtcag cttggtccct ccgccgaata crhmvwgatg attaccgcta ctatcacggg       60

agttacagta atagtcagcc tcatcttccg c                                      91


<210>  132
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RJH80 lambda-DP47

<400>  132
ttcggcggag ggaccaagct gaccgtcc                                          28


<210>  133
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS63

<400>  133
tttcgcacag taatatacgg ccgtgtcc                                          28


<210>  134
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (8H9 ) VL

<400>  134
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gttatgcctc ataatcgcgt attcggcgga      300

gggaccaagc tgaccgtc                                                    318


<210>  135
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (8H9) VH

<400>  135
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgttttc      300

taccgtggtg gtgtttctat ggactactgg ggccaaggaa ccctggtcac cgtctcgagt      360


<210>  136
<211>  321
<212>  DNA
<213>  Artificial  Sequence

<220>
<223>  DNA (49B4) VL

<400>  136
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatagttcgc agccgtatac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  137
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (49B4) VH

<400>  137
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctca            354


<210>  138
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (1G4) VL

<400>  138
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatatttcgt attccatgtt gacgtttggc      300

cagggcacca aagtcgagat caag                                             324


<210>  139
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (1G4) VH

<400>  139
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

ggttctatgg actactgggg ccaagggacc accgtgaccg tctcctca                   348


<210>  140
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (20B7) VL

<400>  140
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatcaggctt tttcgcttac gtttggccag      300

ggcaccaaag tcgagatcaa g                                                321


<210>  141
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (20B7) VH

<400>  141
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagttaac      300

tacccgtact cttactgggg tgacttcgac tactggggcc aagggaccac cgtgaccgtc      360

tcctca                                                                 366


<210>  142
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-563) VL

<400>  142
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caag                                             324


<210>  143
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-563) VH

<400>  143
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcttgacgtt      300

ggtgctttcg actactgggg ccaaggagcc ctggtcaccg tctcgagt                   348


<210>  144
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-564) VL

<400>  144
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caag                                             324


<210>  145
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (CLC-564) VH

<400>  145
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gttcgacgtt      300

ggtccgttcg actactgggg ccaaggaacc ctggtcaccg tctcgagt                   348


<210>  146
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (17A9) VL

<400>  146
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gttatgcctc ataatcgcgt attcggcgga      300

gggaccaagc tgaccgtc                                                    318


<210>  147
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA (17A9) VH

<400>  147
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgttttc      300

taccgtggtg gtgtttctat ggactactgg ggccaaggaa ccctggtcac cgtctcgagt      360


<210>  148
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 8H9 P329GLALA IgG1 light chain

<400>  148
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatttgacgt attcgcggtt tacgtttggc      300

cagggcacca aagtcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  149
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 8H9 P329GLALA IgG1 heavy chain

<400>  149
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

ggttggatgg actactgggg ccaagggacc accgtgaccg tctcctcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  150
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H9 P329GLALA IgG1 light chain

<400>  150

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Thr Tyr Ser Arg 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  151
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8H9 P329GLALA IgG1 Heavy chain

<400>  151

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Trp Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  152
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 49B4 P329GLALA IgG1 light chain

<400>  152
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatagttcgc agccgtatac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  153
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 49B4 P329GLALA IgG1 heavy chain

<400>  153
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      420

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      480

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      540

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      600

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      660

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagctgcagg gggaccgtca      720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      960

aagtgcaagg tctccaacaa agccctcggc gcccccatcg agaaaaccat ctccaaagcc     1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1080

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1140

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1200

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1320

agcctctccc tgtctccggg taaa                                            1344


<210>  154
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49B4 P329GLALA IgG1 light chain

<400>  154

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  155
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49B4 heavy chain

<400>  155

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  156
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 1G4 P329GLALA IgG1 light chain

<400>  156
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatatttcgt attccatgtt gacgtttggc      300

cagggcacca aagtcgagat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  157
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 1G4 P329GLALA IgG1 heavy chain

<400>  157
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

ggttctatgg actactgggg ccaagggacc accgtgaccg tctcctcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  158
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G4 P329GLALA IgG1 light chain

<400>  158

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Ser Tyr Ser Met 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  159
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1G4 P329GLALA IgG1 heavy chain

<400>  159

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Ser Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  160
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA 20B7 P329GLALA IgG1 light chain

<400>  160
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatcaggctt tttcgcttac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  161
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA 20B7 P329GLALA IgG1 heavy chain

<400>  161
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagttaac      300

tacccgtact cttactgggg tgacttcgac tactggggcc aagggaccac cgtgaccgtc      360

tcctcagcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagctgca      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcg gcgcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1356


<210>  162
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  20B7 P329GLALA IgG1 Light chain

<400>  162

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Ala Phe Ser Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  163
<211>  452
<212>  PRT
<213>  Artificial

<220>
<223>  20B7 P329GLALA IgG1 heavy chain

<400>  163

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asn Tyr Pro Tyr Ser Tyr Trp Gly Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  164
<211>  645
<212>  DNA
<213>  Artificial

<220>
<223>  DNA CLC-563 P329GLALA IgG1 light chain

<400>  164
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  165
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  DNA CLC-563 P329GLALA IgG1 heavy chain

<400>  165
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcttgacgtt      300

ggtgctttcg actactgggg ccaaggagcc ctggtcaccg tctcgagtgc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  166
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  CLC-563 P329GLALA IgG1 light chain

<400>  166

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  167
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  CLC-563 P329GLALA IgG1 heavy chain

<400>  167

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Asp Val Gly Ala Phe Asp Tyr Trp Gly Gln Gly Ala Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  168
<211>  645
<212>  DNA
<213>  Artificial

<220>
<223>  DNA CLC-564 P329GLALA IgG1 light chain

<400>  168
gagatcgtgc tgacccagag ccccggcaca ctctccctgt ctcctgggga aagggccacc       60

ctttcatgca gagccagcca gtccgtctct agtagctacc tggcatggta tcagcagaag      120

ccaggacaag ccccccgcct cctgatttac ggcgcttcct ctcgggcaac tggtatccct      180

gacaggttct cagggagcgg aagcggaaca gattttacct tgactatttc tagactggag      240

ccagaggact tcgccgtgta ttactgtcag cagtacggta gtagccccct cacctttggc      300

caggggacaa aagtcgaaat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  169
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  DNA CLC-564 P329GLALA IgG1 heavy chain

<400>  169
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gttcgacgtt      300

ggtccgttcg actactgggg ccaaggaacc ctggtcaccg tctcgagtgc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  170
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  CLC-564 P329GLALA IgG1 light chain

<400>  170

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  171
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  CLC-564 P329GLALA IgG1 heavy chain

<400>  171

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Asp Val Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  172
<211>  639
<212>  DNA
<213>  Artificial

<220>
<223>  DNA 17A9 P329GLALA IgG1 light chain

<400>  172
tcgtctgagc tgactcagga ccctgctgtg tctgtggcct tgggacagac agtcaggatc       60

acatgccaag gagacagcct cagaagttat tatgcaagct ggtaccagca gaagccagga      120

caggcccctg tacttgtcat ctatggtaaa aacaaccggc cctcagggat cccagaccga      180

ttctctggct ccagctcagg aaacacagct tccttgacca tcactggggc tcaggcggaa      240

gatgaggctg actattactg taactcccgt gttatgcctc ataatcgcgt attcggcgga      300

gggaccaagc tgaccgtcct aggtcaaccc aaggctgccc ccagcgtgac cctgttcccc      360

cccagcagcg aggaactgca ggccaacaag gccaccctgg tctgcctgat cagcgacttc      420

tacccaggcg ccgtgaccgt ggcctggaag gccgacagca gccccgtgaa ggccggcgtg      480

gagaccacca cccccagcaa gcagagcaac aacaagtacg ccgccagcag ctacctgagc      540

ctgacccccg agcagtggaa gagccacagg tcctacagct gccaggtgac ccacgagggc      600

agcaccgtgg agaaaaccgt ggcccccacc gagtgcagc                             639


<210>  173
<211>  1350
<212>  DNA
<213>  Artificial

<220>
<223>  DNA 17A9 P329GLALA IgG1 heavy chain

<400>  173
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gcgtgttttc      300

taccgtggtg gtgtttctat ggactactgg ggccaaggaa ccctggtcac cgtctcgagt      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc tgcaggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  174
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  17A9 P329GLALA IgG1 light chain

<400>  174

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Val Met Pro His Asn Arg 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  175
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  17A9 P329GLALA IgG1 heavy chain

<400>  175

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Phe Tyr Arg Gly Gly Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  176
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence LC (pETR16299) OX40 (49B4) VL/CL

<400>  176
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatagttcgc agccgtatac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  177
<211>  2424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Heavy chain 1 (HC1) pETR17237 OX40 (49B4) 
       VHCH1_VHCH1_Fc_knob_PG/LALA_EpCAM (3-17I) VL

<400>  177
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

acaaagggac ctagcgtgtt ccccctggcc cccagcagca agtctacatc tggcggaaca      420

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactctctga gcagcgtcgt gacagtgccc agcagctctc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga acccaagagc      660

tgcgacggcg gagggggatc tggcggcgga ggatcccagg tgcaattggt gcagtctggg      720

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcctc cggaggcaca      780

ttcagcagct acgctataag ctgggtgcga caggcccctg gacaagggct cgagtggatg      840

ggagggatca tccctatctt tggtacagca aactacgcac agaagttcca gggcagggtc      900

accattactg cagacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct      960

gaggacaccg ccgtgtatta ctgtgcgaga gaatactacc gtggtccgta cgactactgg     1020

ggccaaggga ccaccgtgac cgtctcctca gctagcacca agggcccatc ggtcttcccc     1080

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag     1140

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg     1200

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc     1260

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc     1320

aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca cacatgccca     1380

ccgtgcccag cacctgaagc tgcaggggga ccgtcagtct tcctcttccc cccaaaaccc     1440

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1500

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1560

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1620

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1680

ctcggcgccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1740

gtgtacaccc tgcccccctg cagagatgag ctgaccaaga accaggtgtc cctgtggtgt     1800

ctggtcaagg gcttctaccc cagcgatatc gccgtggagt gggagagcaa cggccagcct     1860

gagaacaact acaagaccac cccccctgtg ctggacagcg acggcagctt cttcctgtac     1920

tccaaactga ccgtggacaa gagccggtgg cagcagggca acgtgttcag ctgcagcgtg     1980

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgagcctgag ccccggcgga     2040

ggcggcggaa gcggaggagg aggatccggc ggaggcggat ctggcggggg aggttcggag     2100

atcgtgatga cccagagccc cgccaccctg agtgtgtctc caggcgaaag agccaccctg     2160

tcctgcagag ccagccagag cgtgtccagc aacctggcct ggtatcagca gaagcccggc     2220

caggccccca gactgattat ctacggcgcc agcacaaccg ccagcggcat ccctgccaga     2280

ttttccgcct ctggcagcgg caccgacttc accctgacaa tcagcagcct gcagtccgag     2340

gacttcgccg tgtactactg ccagcagtac aacaactggc cccctgccta caccttcggc     2400

cagggcacca agctggaaat caag                                            2424


<210>  178
<211>  2442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Heavy chain 2 (HC2) pETR17238 OX40 (49B4) 
       VHCH1_VHCH1_Fc_hole_PG/LALA_ EpCAM (3-17I) VH

<400>  178
caggtgcaat tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cctccggagg cacattcagc agctacgcta taagctgggt gcgacaggcc      120

cctggacaag ggctcgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag ggtcaccatt actgcagaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac accgccgtgt attactgtgc gagagaatac      300

taccgtggtc cgtacgacta ctggggccaa gggaccaccg tgaccgtctc ctcagctagc      360

acaaagggac ctagcgtgtt ccccctggcc cccagcagca agtctacatc tggcggaaca      420

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactctctga gcagcgtcgt gacagtgccc agcagctctc tgggcaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga acccaagagc      660

tgcgacggcg gagggggatc tggcggcgga ggatcccagg tgcaattggt gcagtctggg      720

gctgaggtga agaagcctgg gtcctcggtg aaggtctcct gcaaggcctc cggaggcaca      780

ttcagcagct acgctataag ctgggtgcga caggcccctg gacaagggct cgagtggatg      840

ggagggatca tccctatctt tggtacagca aactacgcac agaagttcca gggcagggtc      900

accattactg cagacaaatc cacgagcaca gcctacatgg agctgagcag cctgagatct      960

gaggacaccg ccgtgtatta ctgtgcgaga gaatactacc gtggtccgta cgactactgg     1020

ggccaaggga ccaccgtgac cgtctcctca gctagcacca agggcccatc ggtcttcccc     1080

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag     1140

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg     1200

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc     1260

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc     1320

aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca cacatgccca     1380

ccgtgcccag cacctgaagc tgcaggggga ccgtcagtct tcctcttccc cccaaaaccc     1440

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1500

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1560

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1620

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1680

ctcggcgccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1740

gtgtgcaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctctcgtgc     1800

gcagtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1860

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctcgtg     1920

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1980

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtgga     2040

ggcggcggaa gcggaggagg aggatccggc ggaggcggaa gtggcggcgg aggttcgcag     2100

gtgcagctgg tgcagtctgg cgccgaagtg aagaaacccg gcagcagcgt gaaggtgtcc     2160

tgcaaggctt ccggcggcac cttcagcagc tacgccattt cttgggtgcg ccaggcccct     2220

ggacagggcc tggaatggat gggcggcatc atccccatct tcggcaccgc caactacgcc     2280

cagaaattcc agggcagagt gaccatcacc gccgacgaga gcaccagcac cgcctacatg     2340

gaactgagca gcctgcggag cgaggacacc gccgtgtact attgtgccag aggcctgctg     2400

tggaactact ggggccaggg cacactcgtg accgtgtcct ct                        2442


<210>  179
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Light chain 1 (LC1) pETR16779 OX40 (49B4) VL 
       CL + charges

<400>  179
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga ccgtgtcacc       60

atcacttgcc gtgccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

cgtttcagcg gcagtggatc cgggacagaa ttcactctca ccatcagcag cttgcagcct      240

gatgattttg caacttatta ctgccaacag tatagttcgc agccgtatac gtttggccag      300

ggcaccaaag tcgagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatcgga agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  180
<211>  2739
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Heavy chain pETR17241 OX40 (49B4) 
       VHCH1_49B4VHCH1_Fc _PG/LALA_ EpCAM (3-17I) 3-17l VLCH1 49B4 Fab +
       charges

<400>  180
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ccggcagcag cgtgaaggtg       60

tcctgcaagg cttccggcgg caccttcagc agctacgcca tttcttgggt gcgccaggcc      120

cctggacagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgaca agagcaccag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actactgcgc cagagagtac      300

tacagaggcc cctacgacta ctggggccag ggcacaaccg tgaccgtgtc tagcgccagc      360

acaaagggcc ccagcgtgtt ccctctggcc cctagcagca agagcacatc tggcggaaca      420

gccgccctgg gctgcctggt ggaagattac ttccccgagc ccgtgacagt gtcctggaac      480

tctggcgccc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactcactgt ccagcgtcgt gactgtgccc agcagcagcc tgggaaccca gacctacatc      600

tgcaacgtga accacaagcc cagcaacacc aaggtggacg agaaggtgga acccaagagc      660

tgcgacggcg gaggcggatc tggcggcgga ggatcccagg tgcagctggt gcagagcgga      720

gctgaagtga aaaagcctgg ctcctccgtg aaagtgtctt gtaaagccag cggcggcaca      780

ttctcatcct acgccatcag ctgggtgcgg caggctccag gccagggact ggaatggatg      840

ggaggaatta tccctatttt tgggacagcc aattatgctc agaaatttca ggggcgcgtg      900

acaattacag ccgacaagtc cacctctaca gcttatatgg aactgtcctc cctgcgctcc      960

gaggatacag ctgtgtatta ttgtgcccgc gagtactacc ggggacctta cgattattgg     1020

ggacagggaa ccacagtgac tgtgtcctcc gctagcacca agggaccttc cgtgtttccc     1080

ctggctccca gctccaagtc tacctctggg ggcacagctg ctctgggatg tctggtggaa     1140

gattattttc ctgaacctgt gaccgtgtca tggaacagcg gagccctgac ctccggggtg     1200

cacacattcc ctgctgtgct gcagtcctcc ggcctgtata gcctgagcag cgtcgtgacc     1260

gtgccttcca gctctctggg cacacagaca tatatctgta atgtgaatca caaaccctct     1320

aataccaaag tggatgagaa agtggaacct aagtcctgcg acaagaccca cacctgtccc     1380

ccttgtcctg cccctgaagc tgctggcggc ccatctgtgt ttctgttccc cccaaagccc     1440

aaggacaccc tgatgatcag ccggaccccc gaagtgacct gcgtggtggt ggatgtgtcc     1500

cacgaggacc cagaagtgaa gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc     1560

aagaccaagc cgcgggaaga acagtacaac agcacctacc gggtggtgtc cgtgctgaca     1620

gtgctgcacc aggactggct gaacggcaaa gagtacaagt gcaaggtgtc caacaaggcc     1680

ctgggagccc ccatcgagaa aaccatcagc aaggccaagg gccagccccg cgaacctcag     1740

gtgtacaccc tgcccccaag cagggacgag ctgaccaaga accaggtgtc cctgacctgt     1800

ctcgtgaagg gcttctaccc ctccgatatc gccgtggaat gggagagcaa cggccagccc     1860

gagaacaact acaagaccac cccccctgtg ctggacagcg acggctcatt cttcctgtac     1920

tccaagctga ccgtggacaa gagccggtgg cagcagggca acgtgttcag ctgcagcgtg     1980

atgcacgagg ccctgcacaa ccactacaca cagaagtctc tgagcctgag ccctggcgga     2040

gggggaggat ctgggggagg cggaagtggg ggagggggtt ccggaggcgg tggttcggag     2100

atcgtgatga cccagagccc cgccaccctg agtgtgtctc caggcgaaag agccaccctg     2160

tcctgcagag ccagccagag cgtgtccagc aacctggcct ggtatcagca gaagcccggc     2220

caggccccca gactgattat ctacggcgcc agcacaaccg ccagcggcat ccctgccaga     2280

ttttccgcct ctggcagcgg caccgacttc accctgacaa tcagcagcct gcagtccgag     2340

gacttcgccg tgtactactg ccagcagtac aacaactggc cccctgccta caccttcggc     2400

cagggcacca agctggaaat caagagcagc gcttccacca agggcccctc agtgttccca     2460

ctggcaccat ccagcaagtc cacaagcgga ggaaccgccg ctctgggctg tctcgtgaaa     2520

gactactttc cagagccagt gaccgtgtcc tggaatagtg gcgctctgac ttctggcgtg     2580

cacactttcc ccgcagtgct gcagagttct ggcctgtact ccctgagtag cgtcgtgaca     2640

gtgccctcct ctagcctggg cactcagact tacatctgca atgtgaatca taagccttcc     2700

aacacaaaag tggacaaaaa agtggaaccc aaatcttgc                            2739


<210>  181
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Light chain 2 (LC2) pETR17239 EpCAM (3-17I) 
       VHCL

<400>  181
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ccggcagcag cgtgaaggtg       60

tcctgcaagg cttccggcgg caccttcagc agctacgcca tttcttgggt gcgccaggcc      120

cctggacagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agagcaccag caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgccgtgt actattgtgc cagaggcctg      300

ctgtggaact actggggcca gggcacactc gtgaccgtgt cctctgctag cgtggccgct      360

ccctccgtgt tcatcttccc accttccgac gagcagctga agtccggcac cgcttctgtc      420

gtgtgcctgc tgaacaactt ctacccccgc gaggccaagg tgcagtggaa ggtggacaac      480

gccctgcagt ccggcaacag ccaggaatcc gtgaccgagc aggactccaa ggacagcacc      540

tactccctgt cctccaccct gaccctgtcc aaggccgact acgagaagca caaggtgtac      600

gcctgcgaag tgacccacca gggcctgtct agccccgtga ccaagtcttt caaccggggc      660

gagtgc                                                                 666


<210>  182
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC (pETR16299) OX40 (49B4) VL/CL

<400>  182

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  183
<211>  808
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain 1 (HC1) pETR17237 OX40 (49B4) 
       VHCH1_VHCH1_Fc_knob_PG/LALA_EpCAM (3-17I) VL

<400>  183

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
225                 230                 235                 240 


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
        275                 280                 285             


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
    290                 295                 300                 


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
305                 310                 315                 320 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Tyr Arg Gly Pro 
                325                 330                 335     


Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
            340                 345                 350         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        355                 360                 365             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    370                 375                 380                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
385                 390                 395                 400 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                405                 410                 415     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            420                 425                 430         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
        435                 440                 445             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    450                 455                 460                 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
465                 470                 475                 480 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                485                 490                 495     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            500                 505                 510         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        515                 520                 525             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    530                 535                 540                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
545                 550                 555                 560 


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                565                 570                 575     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
            580                 585                 590         


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        595                 600                 605             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    610                 615                 620                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
625                 630                 635                 640 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                645                 650                 655     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            660                 665                 670         


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr 
    690                 695                 700                 


Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu 
705                 710                 715                 720 


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln 
                725                 730                 735     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile Ile Tyr Gly Ala Ser Thr 
            740                 745                 750         


Thr Ala Ser Gly Ile Pro Ala Arg Phe Ser Ala Ser Gly Ser Gly Thr 
        755                 760                 765             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val 
    770                 775                 780                 


Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro Ala Tyr Thr Phe Gly 
785                 790                 795                 800 


Gln Gly Thr Lys Leu Glu Ile Lys 
                805             


<210>  184
<211>  814
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain 2 (HC2) pETR17238 OX40 (49B4) 
       VHCH1_VHCH1_Fc_hole_PG/LALA_ EpCAM (3-17I) VH

<400>  184

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
225                 230                 235                 240 


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
        275                 280                 285             


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
    290                 295                 300                 


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
305                 310                 315                 320 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Tyr Arg Gly Pro 
                325                 330                 335     


Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
            340                 345                 350         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        355                 360                 365             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    370                 375                 380                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
385                 390                 395                 400 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                405                 410                 415     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            420                 425                 430         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
        435                 440                 445             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    450                 455                 460                 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
465                 470                 475                 480 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                485                 490                 495     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            500                 505                 510         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        515                 520                 525             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    530                 535                 540                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
545                 550                 555                 560 


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                565                 570                 575     


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            580                 585                 590         


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
        595                 600                 605             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    610                 615                 620                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
625                 630                 635                 640 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                645                 650                 655     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            660                 665                 670         


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    690                 695                 700                 


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser 
705                 710                 715                 720 


Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val 
                725                 730                 735     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro 
            740                 745                 750         


Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr 
        755                 760                 765             


Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
    770                 775                 780                 


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Leu Leu 
785                 790                 795                 800 


Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                805                 810                 


<210>  185
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain 1 (LC1) pETR16779 OX40 (49B4) VL CL + charges

<400>  185

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Gln Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Arg Lys Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  186
<211>  913
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain pETR17241 OX40 (49B4) VHCH1_49B4VHCH1_Fc _PG/LALA_ 
       EpCAM (3-17I) 3-17l VLCH1

49B4 Fab + charges

<400>  186

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Tyr Arg Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Glu Lys Val Glu Pro Lys Ser Cys Asp Gly Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
225                 230                 235                 240 


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
                245                 250                 255     


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
            260                 265                 270         


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
        275                 280                 285             


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
    290                 295                 300                 


Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
305                 310                 315                 320 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Tyr Tyr Arg Gly Pro 
                325                 330                 335     


Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
            340                 345                 350         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
        355                 360                 365             


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe Pro 
    370                 375                 380                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
385                 390                 395                 400 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                405                 410                 415     


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
            420                 425                 430         


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Glu Lys Val 
        435                 440                 445             


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    450                 455                 460                 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
465                 470                 475                 480 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                485                 490                 495     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            500                 505                 510         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        515                 520                 525             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    530                 535                 540                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
545                 550                 555                 560 


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                565                 570                 575     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            580                 585                 590         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        595                 600                 605             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    610                 615                 620                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
625                 630                 635                 640 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                645                 650                 655     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            660                 665                 670         


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr 
    690                 695                 700                 


Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu 
705                 710                 715                 720 


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln 
                725                 730                 735     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile Ile Tyr Gly Ala Ser Thr 
            740                 745                 750         


Thr Ala Ser Gly Ile Pro Ala Arg Phe Ser Ala Ser Gly Ser Gly Thr 
        755                 760                 765             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val 
    770                 775                 780                 


Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro Ala Tyr Thr Phe Gly 
785                 790                 795                 800 


Gln Gly Thr Lys Leu Glu Ile Lys Ser Ser Ala Ser Thr Lys Gly Pro 
                805                 810                 815     


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
            820                 825                 830         


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
        835                 840                 845             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    850                 855                 860                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
865                 870                 875                 880 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                885                 890                 895     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
            900                 905                 910         


Cys 
    


<210>  187
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain 2 (LC2) pETR17239 EpCAM (3-17I) VHCL

<400>  187

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Leu Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    130                 135                 140                 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
145                 150                 155                 160 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
                165                 170                 175     


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
            180                 185                 190         


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        195                 200                 205             


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220         


<210>  188
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Light chain (LC) muOX40 (OX86)VL/CL 
       (pETR14908)

<400>  188
gatattgtga tgacccaggg tgcactcccc aatcctgtcc cttctggaga gtcagcttcc       60

atcacctgca ggtctagtca gagtctggta tacaaagacg gccagacata cttgaattgg      120

tttctgcaga ggccaggaca gtctcctcag cttctgacct attggatgtc tacccgtgca      180

tcaggagtct cagacaggtt cagtggcagt gggtcaggaa catatttcac actgaaaatc      240

agtagagtga gggctgagga tgcgggtgtg tattactgtc agcaagttcg agagtatcct      300

ttcactttcg gctcagggac gaagttggaa ataaaacgtg ccgatgctgc accaactgta      360

tcgattttcc caccatccag tgagcagtta acatctggag gtgcctcagt cgtgtgcttc      420

ttgaacaact tctaccccaa agacatcaat gtcaagtgga agattgatgg cagtgaacga      480

caaaatggcg tcctgaacag ttggactgat caggacagca aagacagcac ctacagcatg      540

agcagcaccc tcacgttgac caaggacgag tatgaacgac ataacagcta tacctgtgag      600

gccactcaca agacatcaac ttcacccatt gtcaagagct tcaacaggaa tgagtgt         657


<210>  189
<211>  2388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Heavy chain 1 (HC1) pETR16412 muOX40 (OX86) 
       VHCH1_VHCH1_Fc_hole_DAPG_DD muEpCAM (G8.8) VL

<400>  189
caggtgcagc tgaaggagtc tggacctggt ctggtgcagc cctcacagac cctgtccctc       60

acctgcactg tctctgggtt ctcactaacc ggttacaatt tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gatgggaaga atgaggtatg atggagacac atattataat      180

tcagttctca aatcccgact gagcatcagc agggacacct ccaagaacca agttttcttg      240

aaaatgaaca gtctgcaaac ggatgacaca gccatttact attgtaccag agacgggcgt      300

ggtgactcct ttgattactg gggccaagga gtcatggtca cagtctccag cgctaagacc      360

acccccccct ccgtgtatcc tctggctcct ggatctgccg cccagaccaa cagcatggtc      420

accctgggct gcctcgtgaa gggctacttc cctgagcctg tgaccgtgac ctggaactcc      480

ggctctctgt cctctggcgt gcacaccttc cctgccgtgc tgcagtccga cctgtacacc      540

ctgtcctcca gcgtgaccgt gccttcctcc acctggcctt cccagaccgt gacatgcaac      600

gtggcccacc ctgccagctc caccaaggtg gacaagaaaa tcgtgccccg ggactgcgga      660

gggggcggtt ccggcggagg aggatcccag gtgcagctga aggagtctgg acctggtctg      720

gtgcagccct cacagaccct gtccctcacc tgcactgtct ctgggttctc actaaccggt      780

tacaatttac actgggttcg ccagcctcca ggaaagggtc tggagtggat gggaagaatg      840

aggtatgatg gagacacata ttataattca gttctcaaat cccgactgag catcagcagg      900

gacacctcca agaaccaagt tttcttgaaa atgaacagtc tgcaaacgga tgacacagcc      960

atttactatt gtaccagaga cgggcgtggt gactcctttg attactgggg ccaaggagtc     1020

atggtcacag tctccagcgc taagaccacc ccccctagcg tgtaccctct ggcccctgga     1080

tctgccgccc agaccaacag catggtgacc ctgggctgcc tggtgaaggg ctacttcccc     1140

gagcctgtga ccgtgacctg gaacagcggc agcctgagca gcggcgtgca cacctttcca     1200

gccgtgctgc agagcgacct gtacaccctg agcagctccg tgaccgtgcc tagcagcacc     1260

tggcccagcc agacagtgac ctgcaacgtg gcccaccctg ccagcagcac caaggtggac     1320

aagaaaatcg tgccccggga ctgcggctgc aagccctgca tctgcaccgt gcccgaggtg     1380

tccagcgtgt tcatcttccc acccaagccc aaggacgtgc tgaccatcac cctgaccccc     1440

aaagtgacct gcgtggtggt ggccatcagc aaggacgacc ccgaggtgca gttctcttgg     1500

tttgtggacg acgtggaggt gcacacagcc cagacaaagc cccgggagga acagatcaac     1560

agcaccttca gaagcgtgtc cgagctgccc atcatgcacc aggactggct gaacggcaaa     1620

gaattcaagt gcagagtgaa cagcgccgcc ttcggcgccc ccatcgagaa aaccatcagc     1680

aagaccaagg gcagacccaa ggccccccag gtgtacacca tccccccacc caaagaacag     1740

atggccaagg acaaggtgtc cctgacctgc atgatcacca actttttccc cgaggacatc     1800

accgtggagt ggcagtggaa tggccagccc gccgagaact acgacaacac ccagcccatc     1860

atggacaccg acggcagcta cttcgtgtac agcgacctga acgtgcagaa gtccaactgg     1920

gaggccggca acaccttcac ctgtagcgtg ctgcacgagg gcctgcacaa ccaccacacc     1980

gagaagtccc tgagccacag cccaggcggc ggaggcggat ctggcggagg aggttccggt     2040

ggcggaggtt ccggaggcgg tggatccgac atccagatga cacagagccc cgccagcctg     2100

agcgcctctc tgggcgagac agtgtccatc gagtgcctgg ccagcgaggg catcagcaac     2160

gacctggcct ggtatcagca gaagtccggc aagagccccc agctgctgat ctacgccacc     2220

agcagactgc aggacggcgt gcccagcaga ttcagcggca gcggctccgg cacccggtac     2280

agcctgaaga tcagcggcat gcagcccgag gacgaggccg actacttctg ccagcagagc     2340

tacaagtacc cctggacctt cggcggcggc accaagctgg aactgaag                  2388


<210>  190
<211>  2430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence Heavy chain 2 (HC2) pETR16443 muOX40 (OX86) 
       VHCH1_VHCH1_Fc_knob_DAPG_KK_muEpCAM (G8.8) VH

<400>  190
caggtgcagc tgaaggagtc tggacctggt ctggtgcagc cctcacagac cctgtccctc       60

acctgcactg tctctgggtt ctcactaacc ggttacaatt tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gatgggaaga atgaggtatg atggagacac atattataat      180

tcagttctca aatcccgact gagcatcagc agggacacct ccaagaacca agttttcttg      240

aaaatgaaca gtctgcaaac ggatgacaca gccatttact attgtaccag agacgggcgt      300

ggtgactcct ttgattactg gggccaagga gtcatggtca cagtctccag cgctaagacc      360

acccccccct ccgtgtatcc tctggctcct ggatctgccg cccagaccaa cagcatggtc      420

accctgggct gcctcgtgaa gggctacttc cctgagcctg tgaccgtgac ctggaactcc      480

ggctctctgt cctctggcgt gcacaccttc cctgccgtgc tgcagtccga cctgtacacc      540

ctgtcctcca gcgtgaccgt gccttcctcc acctggcctt cccagaccgt gacatgcaac      600

gtggcccacc ctgccagctc caccaaggtg gacaagaaaa tcgtgccccg ggactgcgga      660

gggggcggtt ccggcggagg aggatcccag gtgcagctga aggagtctgg acctggtctg      720

gtgcagccct cacagaccct gtccctcacc tgcactgtct ctgggttctc actaaccggt      780

tacaatttac actgggttcg ccagcctcca ggaaagggtc tggagtggat gggaagaatg      840

aggtatgatg gagacacata ttataattca gttctcaaat cccgactgag catcagcagg      900

gacacctcca agaaccaagt tttcttgaaa atgaacagtc tgcaaacgga tgacacagcc      960

atttactatt gtaccagaga cgggcgtggt gactcctttg attactgggg ccaaggagtc     1020

atggtcacag tctccagcgc taagaccacc ccccctagcg tgtaccctct ggcccctgga     1080

tctgccgccc agaccaacag catggtgacc ctgggctgcc tggtgaaggg ctacttcccc     1140

gagcctgtga ccgtgacctg gaacagcggc agcctgagca gcggcgtgca cacctttcca     1200

gccgtgctgc agagcgacct gtacaccctg agcagctccg tgaccgtgcc tagcagcacc     1260

tggcccagcc agacagtgac ctgcaacgtg gcccaccctg ccagcagcac caaggtggac     1320

aagaaaatcg tgccccggga ctgcggctgc aagccctgca tctgcaccgt gcccgaggtg     1380

tccagcgtgt tcatcttccc acccaagccc aaggacgtgc tgaccatcac cctgaccccc     1440

aaagtgacct gcgtggtggt ggccatcagc aaggacgacc ccgaggtgca gttctcttgg     1500

tttgtggacg acgtggaggt gcacacagcc cagacaaagc cccgggagga acagatcaac     1560

agcaccttca gaagcgtgtc cgagctgccc atcatgcacc aggactggct gaacggcaaa     1620

gaattcaagt gcagagtgaa ctccgccgcc tttggcgccc ctatcgaaaa gaccatctcc     1680

aagaccaagg gcagacccaa ggccccccag gtgtacacaa tccccccacc caagaaacag     1740

atggccaagg acaaggtgtc cctgacctgc atgatcacca actttttccc agaggacatc     1800

accgtggaat ggcagtggaa cggccagccc gccgagaact acaagaacac ccagcccatc     1860

atgaagaccg acggctccta cttcgtgtac tccaagctga acgtgcagaa gtccaactgg     1920

gaggccggca acaccttcac ctgttccgtg ctgcacgagg gcctgcacaa ccaccacacc     1980

gagaagtccc tgtcccactc tcctggcgga ggcggaggat ctggtggcgg tggttctggc     2040

ggtggcggtt ccggaggcgg tggttccgaa gtgcagctgg ccgagagcgg cggaggcctg     2100

gtgcagcctg gcagatccat gaagctgagc tgcgccgcca gcggcttcac cttcagcaac     2160

ttccccatgg cctgggtccg acaggccccc accaagggcc tggaatgggt ggccaccatc     2220

agcaccagcg gcggcagcac ctactaccgg gacagcgtga agggccggtt caccatcagc     2280

cgggacaacg ccaagagcac cctgtacctg cagatgaaca gcctgcggag cgaggacacc     2340

gccacctact actgcacccg gaccctgtat atcctgcggg tgttctactt cgactactgg     2400

ggccagggcg tgatggtcac cgtgtctagc                                      2430


<210>  191
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain (LC) muOX40 (OX86)VL/CL (pETR14908)

<400>  191

Asp Ile Val Met Thr Gln Gly Ala Leu Pro Asn Pro Val Pro Ser Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Thr Cys Arg Ser Ser Gln Ser Leu Val Tyr Lys 
            20                  25                  30          


Asp Gly Gln Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Thr Tyr Trp Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Arg Ala Glu Asp Ala Gly Val Tyr Tyr Cys Gln Gln Val 
                85                  90                  95      


Arg Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  192
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain 1 (HC1) pETR16412 muOX40 (OX86) 
       VHCH1_VHCH1_Fc_hole_DAPG_DD muEpCAM (G8.8) VL

<400>  192

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Asn Leu His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu 
225                 230                 235                 240 


Val Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe 
                245                 250                 255     


Ser Leu Thr Gly Tyr Asn Leu His Trp Val Arg Gln Pro Pro Gly Lys 
            260                 265                 270         


Gly Leu Glu Trp Met Gly Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr 
        275                 280                 285             


Asn Ser Val Leu Lys Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys 
    290                 295                 300                 


Asn Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
305                 310                 315                 320 


Ile Tyr Tyr Cys Thr Arg Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp 
                325                 330                 335     


Gly Gln Gly Val Met Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
            340                 345                 350         


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
        355                 360                 365             


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
    370                 375                 380                 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
385                 390                 395                 400 


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
                405                 410                 415     


Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His 
            420                 425                 430         


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
        435                 440                 445             


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
    450                 455                 460                 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
465                 470                 475                 480 


Lys Val Thr Cys Val Val Val Ala Ile Ser Lys Asp Asp Pro Glu Val 
                485                 490                 495     


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
            500                 505                 510         


Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr Phe Arg Ser Val Ser Glu 
        515                 520                 525             


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
    530                 535                 540                 


Arg Val Asn Ser Ala Ala Phe Gly Ala Pro Ile Glu Lys Thr Ile Ser 
545                 550                 555                 560 


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
                565                 570                 575     


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
            580                 585                 590         


Thr Asn Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
        595                 600                 605             


Gln Pro Ala Glu Asn Tyr Asp Asn Thr Gln Pro Ile Met Asp Thr Asp 
    610                 615                 620                 


Gly Ser Tyr Phe Val Tyr Ser Asp Leu Asn Val Gln Lys Ser Asn Trp 
625                 630                 635                 640 


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
                645                 650                 655     


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu 
    690                 695                 700                 


Gly Glu Thr Val Ser Ile Glu Cys Leu Ala Ser Glu Gly Ile Ser Asn 
705                 710                 715                 720 


Asp Leu Ala Trp Tyr Gln Gln Lys Ser Gly Lys Ser Pro Gln Leu Leu 
                725                 730                 735     


Ile Tyr Ala Thr Ser Arg Leu Gln Asp Gly Val Pro Ser Arg Phe Ser 
            740                 745                 750         


Gly Ser Gly Ser Gly Thr Arg Tyr Ser Leu Lys Ile Ser Gly Met Gln 
        755                 760                 765             


Pro Glu Asp Glu Ala Asp Tyr Phe Cys Gln Gln Ser Tyr Lys Tyr Pro 
    770                 775                 780                 


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
785                 790                 795     


<210>  193
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain 2 (HC2) pETR16443 muOX40 (OX86) 
       VHCH1_VHCH1_Fc_knob_DAPG_KK_muEpCAM (G8.8) VH

<400>  193

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Asn Leu His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Gln Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu 
225                 230                 235                 240 


Val Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe 
                245                 250                 255     


Ser Leu Thr Gly Tyr Asn Leu His Trp Val Arg Gln Pro Pro Gly Lys 
            260                 265                 270         


Gly Leu Glu Trp Met Gly Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr 
        275                 280                 285             


Asn Ser Val Leu Lys Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys 
    290                 295                 300                 


Asn Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
305                 310                 315                 320 


Ile Tyr Tyr Cys Thr Arg Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp 
                325                 330                 335     


Gly Gln Gly Val Met Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
            340                 345                 350         


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
        355                 360                 365             


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
    370                 375                 380                 


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
385                 390                 395                 400 


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
                405                 410                 415     


Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Asn Val Ala His 
            420                 425                 430         


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
        435                 440                 445             


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
    450                 455                 460                 


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
465                 470                 475                 480 


Lys Val Thr Cys Val Val Val Ala Ile Ser Lys Asp Asp Pro Glu Val 
                485                 490                 495     


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
            500                 505                 510         


Lys Pro Arg Glu Glu Gln Ile Asn Ser Thr Phe Arg Ser Val Ser Glu 
        515                 520                 525             


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
    530                 535                 540                 


Arg Val Asn Ser Ala Ala Phe Gly Ala Pro Ile Glu Lys Thr Ile Ser 
545                 550                 555                 560 


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
                565                 570                 575     


Pro Lys Lys Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
            580                 585                 590         


Thr Asn Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
        595                 600                 605             


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Lys Thr Asp 
    610                 615                 620                 


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
625                 630                 635                 640 


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
                645                 650                 655     


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        675                 680                 685             


Ser Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    690                 695                 700                 


Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn 
705                 710                 715                 720 


Phe Pro Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp 
                725                 730                 735     


Val Ala Thr Ile Ser Thr Ser Gly Gly Ser Thr Tyr Tyr Arg Asp Ser 
            740                 745                 750         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu 
        755                 760                 765             


Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr 
    770                 775                 780                 


Cys Thr Arg Thr Leu Tyr Ile Leu Arg Val Phe Tyr Phe Asp Tyr Trp 
785                 790                 795                 800 


Gly Gln Gly Val Met Val Thr Val Ser Ser 
                805                 810 


