                         SEQUENCE LISTING

<110>  SUNNYBROOK RESEARCH INSTITUTE
 
<120>  ENGINEERED T-CELL MODULATING MOLECULES AND METHODS OF USING SAME

<130>  35475-2029

<140>  PCT/CA2018/050382
<141>  2018-03-28

<150>  US 62/590,848
<151>  2017-11-27

<150>  US 62/478,198
<151>  2017-03-29

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VISTA extracellular domain cDNA sequence (human)

<400>  1
ttcaaggtcg ccacgccgta ttccctgtat gtctgtcccg aggggcagaa cgtcaccctc       60

acctgcaggc tcttgggccc tgtggacaaa gggcacgatg tgaccttcta caagacgtgg      120

taccgcagct cgaggggcga ggtgcagacc tgctcagagc gccggcccat ccgcaacctc      180

acgttccagg accttcacct gcaccatgga ggccaccagg ctgccaacac cagccacgac      240

ctggctcagc gccacgggct ggagtcggcc tccgaccacc atggcaactt ctccatcacc      300

atgcgcaacc tgaccctgct ggatagcggc ctctactgct gcctggtggt ggagatcagg      360

caccaccact cggagcacag ggtccatggt gccatggagc tgcaggtgca gacaggcaaa      420

gatgcaccat ccaactgtgt ggtgtaccca tcctcctccc aggatagtga aaacatcacg      480

gct                                                                    483


<210>  2
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VISTA extracellular domain cDNA sequence (mouse)

<400>  2
ttcaaggtca ccactccata ttctctctat gtgtgtcccg agggacagaa tgccaccctc       60

acctgcagga ttctgggccc cgtgtccaaa gggcacgatg tgaccatcta caagacgtgg      120

tacctcagct cacgaggcga ggtccagatg tgcaaagaac accggcccat acgcaacttc      180

acattgcagc accttcagca ccacggaagc cacctgaaag ccaacgccag ccatgaccag      240

ccccagaagc atgggctaga gctagcttct gaccaccacg gtaacttctc tatcaccctg      300

cgcaatgtga ccccaaggga cagcggcctc tactgctgtc tagtgataga attaaaaaac      360

caccacccag aacaacggtt ctacgggtcc atggagctac aggtacaggc aggcaaaggc      420

tcggggtcca catgcatggc gtctaatgag caggacagtg acagcatcac ggct            474


<210>  3
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COMP pentamerization domain cDNA sequence (human)

<400>  3
gacctgggcc cgcagatgct tcgggaactg caggaaacca acgcggcgct gcaggacgtg       60

cgggagctgc tgcggcagca ggtcagggag atcacgttcc tgaaaaacac ggtgatggag      120

tgtgacgcgt gcggg                                                       135


<210>  4
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COMP pentamerization domain cDNA sequence (mouse)

<400>  4
gacctggccc cacagatgct gcgagaactt caggagacta atgcggcgct gcaagacgtg       60

agagagctgt tgcgacagca ggtcaaggag atcaccttcc tgaagaatac ggtgatggaa      120

tgtgatgctt gcgga                                                       135


<210>  5
<211>  483
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  VISTA extracellular domain mRNA sequence (human)

<400>  5
uucaaggucg ccacgccgua uucccuguau gucugucccg aggggcagaa cgucacccuc       60

accugcaggc ucuugggccc uguggacaaa gggcacgaug ugaccuucua caagacgugg      120

uaccgcagcu cgaggggcga ggugcagacc ugcucagagc gccggcccau ccgcaaccuc      180

acguuccagg accuucaccu gcaccaugga ggccaccagg cugccaacac cagccacgac      240

cuggcucagc gccacgggcu ggagucggcc uccgaccacc auggcaacuu cuccaucacc      300

augcgcaacc ugacccugcu ggauagcggc cucuacugcu gccugguggu ggagaucagg      360

caccaccacu cggagcacag gguccauggu gccauggagc ugcaggugca gacaggcaaa      420

gaugcaccau ccaacugugu gguguaccca uccuccuccc aggauaguga aaacaucacg      480

gcu                                                                    483


<210>  6
<211>  474
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  VISTA extracellular domain mRNA sequence (mouse)

<400>  6
uucaagguca ccacuccaua uucucucuau gugugucccg agggacagaa ugccacccuc       60

accugcagga uucugggccc cguguccaaa gggcacgaug ugaccaucua caagacgugg      120

uaccucagcu cacgaggcga gguccagaug ugcaaagaac accggcccau acgcaacuuc      180

acauugcagc accuucagca ccacggaagc caccugaaag ccaacgccag ccaugaccag      240

ccccagaagc augggcuaga gcuagcuucu gaccaccacg guaacuucuc uaucacccug      300

cgcaauguga ccccaaggga cagcggccuc uacugcuguc uagugauaga auuaaaaaac      360

caccacccag aacaacgguu cuacgggucc auggagcuac agguacaggc aggcaaaggc      420

ucggggucca caugcauggc gucuaaugag caggacagug acagcaucac ggcu            474


<210>  7
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  COMP pentamerization domain mRNA sequence (human)

<400>  7
gaccugggcc cgcagaugcu ucgggaacug caggaaacca acgcggcgcu gcaggacgug       60

cgggagcugc ugcggcagca ggucagggag aucacguucc ugaaaaacac ggugauggag      120

ugugacgcgu gcggg                                                       135


<210>  8
<211>  135
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  COMP pentamerization domain mRNA sequence (mouse)

<400>  8
gaccuggccc cacagaugcu gcgagaacuu caggagacua augcggcgcu gcaagacgug       60

agagagcugu ugcgacagca ggucaaggag aucaccuucc ugaagaauac ggugauggaa      120

ugugaugcuu gcgga                                                       135


<210>  9
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VISTA extracellular domain amino acid sequence (human)

<400>  9

Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
            20                  25                  30          


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
    50                  55                  60                  


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
65                  70                  75                  80  


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
                85                  90                  95      


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
            100                 105                 110         


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
        115                 120                 125             


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
    130                 135                 140                 


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
145                 150                 155                 160 


Ala 
    


<210>  10
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VISTA extracellular domain amino acid sequence (mouse)

<400>  10

Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
1               5                   10                  15      


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
            20                  25                  30          


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
        35                  40                  45              


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
    50                  55                  60                  


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
65                  70                  75                  80  


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
                85                  90                  95      


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
            100                 105                 110         


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
        115                 120                 125             


Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys Gly Ser Gly Ser Thr 
    130                 135                 140                 


Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser Ile Thr Ala 
145                 150                 155             


<210>  11
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COMP pentamerization domain amino acid sequence (human)

<400>  11

Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala 
1               5                   10                  15      


Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr 
            20                  25                  30          


Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly 
        35                  40                  45  


<210>  12
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COMP pentamerization domain amino acid sequence (mouse)

<400>  12

Asp Leu Ala Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala 
1               5                   10                  15      


Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Lys Glu Ile Thr 
            20                  25                  30          


Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly 
        35                  40                  45  


<210>  13
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized mVISTA.COMP DNA sequence (mouse)

<400>  13
aagcttgcca ccatggaaac cgacaccctg ctgctgtggg tgctgctgct gtgggtgcca       60

ggcagcaccg gcgaattcaa agtgaccacc ccctacagcc tgtacgtgtg ccccgagggc      120

cagaatgcca ccctgacctg tagaatcctg ggccccgtgt ccaagggcca cgacgtgacc      180

atctacaaga cctggtatct gagcagcaga ggcgaggtgc agatgtgcaa agagcaccgg      240

cccatccgga acttcaccct gcagcatctg cagcaccacg gcagccacct gaaggccaat      300

gccagccacg accagcctca gaagcacggc ctggaactgg cctctgacca ccacggaaac      360

ttcagcatca ccctgcggaa cgtgaccccc agagacagcg gcctgtactg ctgtctcgtg      420

atcgagctga agaaccacca ccccgagcag cggttctacg gcagcatgga actgcaggtc      480

caggccggca agggcagcgg ctctacttgc atggccagca acgagcagga cagcgactcc      540

atcacagccg aattcggctc tggaccaggt ccatcgggta ccgatctggc cccccagatg      600

ctgagagagc tgcaggaaac aaacgccgcc ctgcaggacg tgcgcgagct gctgagacag      660

caagtgaaag agatcacctt cctgaagaac accgtgatgg aatgcgacgc ctgcggcggc      720

tctccacaac cacagtctga gaacctgtat tttcaaggcg gcccacaacc acagggcgga      780

tccggctctg gctctggcgg ccgccaccac catcatcacc atcaccactg atga            834


<210>  14
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mVISTA.COMP amino acid sequence (mouse)

<400>  14

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val 
            20                  25                  30          


Cys Pro Glu Gly Gln Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro 
        35                  40                  45              


Val Ser Lys Gly His Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser 
    50                  55                  60                  


Ser Arg Gly Glu Val Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn 
65                  70                  75                  80  


Phe Thr Leu Gln His Leu Gln His His Gly Ser His Leu Lys Ala Asn 
                85                  90                  95      


Ala Ser His Asp Gln Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp 
            100                 105                 110         


His His Gly Asn Phe Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp 
        115                 120                 125             


Ser Gly Leu Tyr Cys Cys Leu Val Ile Glu Leu Lys Asn His His Pro 
    130                 135                 140                 


Glu Gln Arg Phe Tyr Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys 
145                 150                 155                 160 


Gly Ser Gly Ser Thr Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser 
                165                 170                 175     


Ile Thr Ala Glu Phe Gly Ser Gly Pro Gly Pro Ser Gly Thr Asp Leu 
            180                 185                 190         


Ala Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln 
        195                 200                 205             


Asp Val Arg Glu Leu Leu Arg Gln Gln Val Lys Glu Ile Thr Phe Leu 
    210                 215                 220                 


Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly Gly Ser Pro Gln Pro 
225                 230                 235                 240 


Gln Ser Glu Asn Leu Tyr Phe Gln Gly Gly Pro Gln Pro Gln Gly Gly 
                245                 250                 255     


Ser Gly Ser Gly Ser Gly Gly Arg His His His His His His His His 
            260                 265                 270         


<210>  15
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length VISTA amino acid sequence (human)

<400>  15

Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210>  16
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length VISTA amino acid sequence (mouse)

<400>  16

Met Gly Val Pro Ala Val Pro Glu Ala Ser Ser Pro Arg Trp Gly Thr 
1               5                   10                  15      


Leu Leu Leu Ala Ile Phe Leu Ala Ala Ser Arg Gly Leu Val Ala Ala 
            20                  25                  30          


Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
    50                  55                  60                  


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
                85                  90                  95      


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
            100                 105                 110         


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
        115                 120                 125             


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
    130                 135                 140                 


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
145                 150                 155                 160 


Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys Gly Ser Gly Ser Thr 
                165                 170                 175     


Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser Ile Thr Ala Ala Ala 
            180                 185                 190         


Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu Pro Leu Ile 
        195                 200                 205             


Leu Leu Leu Val Tyr Lys Gln Arg Gln Val Ala Ser His Arg Arg Ala 
    210                 215                 220                 


Gln Glu Leu Val Arg Met Asp Ser Asn Thr Gln Gly Ile Glu Asn Pro 
225                 230                 235                 240 


Gly Phe Glu Thr Thr Pro Pro Phe Gln Gly Met Pro Glu Ala Lys Thr 
                245                 250                 255     


Arg Pro Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser Glu Ser Gly 
            260                 265                 270         


Arg Tyr Leu Leu Ser Asp Pro Ser Thr Pro Leu Ser Pro Pro Gly Pro 
        275                 280                 285             


Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp Ser Pro Asn 
    290                 295                 300                 


Ser Glu Ala Ile 
305             


<210>  17
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length COMP amino acid sequence (human)

<400>  17

Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 
            20                  25                  30          


Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 
        35                  40                  45              


Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 
    50                  55                  60                  


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 
65                  70                  75                  80  


Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 
                85                  90                  95      


Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 
            100                 105                 110         


Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 
        115                 120                 125             


Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn 
    130                 135                 140                 


Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly 
145                 150                 155                 160 


Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln 
                165                 170                 175     


Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val 
            180                 185                 190         


Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro 
        195                 200                 205             


Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg 
    210                 215                 220                 


Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His 
225                 230                 235                 240 


Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala 
                245                 250                 255     


Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu 
            260                 265                 270         


Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg 
        275                 280                 285             


Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp 
    290                 295                 300                 


Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly 
305                 310                 315                 320 


Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln 
                325                 330                 335     


Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg 
            340                 345                 350         


Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly 
        355                 360                 365             


Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala 
    370                 375                 380                 


Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly 
385                 390                 395                 400 


Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro 
                405                 410                 415     


Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser 
            420                 425                 430         


Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys 
        435                 440                 445             


Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln 
    450                 455                 460                 


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser 
465                 470                 475                 480 


Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp 
                485                 490                 495     


Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys 
            500                 505                 510         


Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu 
        515                 520                 525             


Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp 
    530                 535                 540                 


Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile 
545                 550                 555                 560 


Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala 
                565                 570                 575     


Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr 
            580                 585                 590         


Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser 
        595                 600                 605             


Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 
    610                 615                 620                 


Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val 
625                 630                 635                 640 


Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His 
                645                 650                 655     


Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg 
            660                 665                 670         


Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His 
        675                 680                 685             


Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu 
    690                 695                 700                 


Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly 
705                 710                 715                 720 


Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn 
                725                 730                 735     


Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His 
            740                 745                 750         


Gln Leu Arg Gln Ala 
        755         


<210>  18
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length COMP amino acid sequence (mouse)

<400>  18

Met Gly Pro Thr Ala Cys Val Leu Val Leu Ala Leu Ala Ile Leu Arg 
1               5                   10                  15      


Ala Thr Gly Gln Gly Gln Ile Pro Leu Gly Gly Asp Leu Ala Pro Gln 
            20                  25                  30          


Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg 
        35                  40                  45              


Glu Leu Leu Arg Gln Gln Val Lys Glu Ile Thr Phe Leu Lys Asn Thr 
    50                  55                  60                  


Val Met Glu Cys Asp Ala Cys Gly Met Gln Pro Ala Arg Thr Pro Gly 
65                  70                  75                  80  


Leu Ser Val Arg Pro Val Pro Leu Cys Ala Pro Gly Ser Cys Phe Pro 
                85                  90                  95      


Gly Val Val Cys Ser Glu Thr Ala Thr Gly Ala Arg Cys Gly Pro Cys 
            100                 105                 110         


Pro Pro Gly Tyr Thr Gly Asn Gly Ser His Cys Thr Asp Val Asn Glu 
        115                 120                 125             


Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn Thr Ser 
    130                 135                 140                 


Pro Gly Phe His Cys Glu Ala Cys Pro Pro Gly Phe Ser Gly Pro Thr 
145                 150                 155                 160 


His Glu Gly Val Gly Leu Thr Phe Ala Lys Ser Asn Lys Gln Val Cys 
                165                 170                 175     


Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val Pro Asn 
            180                 185                 190         


Ser Val Cys Val Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro Cys Gln 
        195                 200                 205             


Pro Gly Phe Val Gly Asp Gln Thr Ser Gly Cys Gln Arg Arg Gly Gln 
    210                 215                 220                 


His Phe Cys Pro Asp Gly Ser Pro Ser Pro Cys His Glu Lys Ala Asn 
225                 230                 235                 240 


Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala Val Gly 
                245                 250                 255     


Trp Ala Gly Asn Gly Leu Leu Cys Gly Arg Asp Thr Asp Leu Asp Gly 
            260                 265                 270         


Phe Pro Asp Glu Lys Leu Arg Cys Ser Glu Arg Gln Cys Arg Lys Asp 
        275                 280                 285             


Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp Arg Asp 
    290                 295                 300                 


Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly Val Pro 
305                 310                 315                 320 


Asn Glu Gln Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln Arg Asn 
                325                 330                 335     


Ser Asp Ser Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg Ser Lys 
            340                 345                 350         


Lys Asn Asp Asp Gln Lys Asp Thr Asp Leu Asp Gly Arg Gly Asp Ala 
        355                 360                 365             


Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Val Ala Asp Asn 
    370                 375                 380                 


Cys Pro Arg Val Pro Asn Phe Asp Gln Ser Asp Ser Asp Gly Asp Gly 
385                 390                 395                 400 


Val Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Asp Asn Pro Asp Gln 
                405                 410                 415     


Arg Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser Asp Gln 
            420                 425                 430         


Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys Pro Thr 
        435                 440                 445             


Val Pro Asn Ser Ala Gln Gln Asp Ser Asp His Asp Gly Lys Gly Asp 
    450                 455                 460                 


Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser Arg Asp 
465                 470                 475                 480 


Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Asn Asp Arg Asp 
                485                 490                 495     


Gly Val Gly Asp Ala Cys Gln Gly Asp Phe Asp Ala Asp Lys Val Ile 
            500                 505                 510         


Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr Asp 
        515                 520                 525             


Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala Gln 
    530                 535                 540                 


Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Met Glu Ile Val Gln 
545                 550                 555                 560 


Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn 
                565                 570                 575     


Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Ala Thr Asp Asp 
            580                 585                 590         


Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe Tyr 
        595                 600                 605             


Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn Pro 
    610                 615                 620                 


Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser 
625                 630                 635                 640 


Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr Gly 
                645                 650                 655     


Asp Thr Ala Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg Asn Val 
            660                 665                 670         


Gly Trp Lys Asp Lys Thr Ser Tyr Arg Trp Phe Leu Gln His Arg Pro 
        675                 680                 685             


Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu Leu Val 
    690                 695                 700                 


Ala Asp Ser Asn Val Val Leu Asp Thr Ala Met Arg Gly Gly Arg Leu 
705                 710                 715                 720 


Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn Leu Arg 
                725                 730                 735     


Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Ser His Arg Leu 
            740                 745                 750         


Gln Arg Val 
        755 


<210>  19
<211>  4774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VISTA cDNA nucleotide sequence (human)

<400>  19
gggggcgggt gcctggagca cggcgctggg gccgcccgca gcgctcactc gctcgcactc       60

agtcgcggga ggcttccccg cgccggccgc gtcccgcccg ctccccggca ccagaagttc      120

ctctgcgcgt ccgacggcga catgggcgtc cccacggccc tggaggccgg cagctggcgc      180

tggggatccc tgctcttcgc tctcttcctg gctgcgtccc taggtccggt ggcagccttc      240

aaggtcgcca cgccgtattc cctgtatgtc tgtcccgagg ggcagaacgt caccctcacc      300

tgcaggctct tgggccctgt ggacaaaggg cacgatgtga ccttctacaa gacgtggtac      360

cgcagctcga ggggcgaggt gcagacctgc tcagagcgcc ggcccatccg caacctcacg      420

ttccaggacc ttcacctgca ccatggaggc caccaggctg ccaacaccag ccacgacctg      480

gctcagcgcc acgggctgga gtcggcctcc gaccaccatg gcaacttctc catcaccatg      540

cgcaacctga ccctgctgga tagcggcctc tactgctgcc tggtggtgga gatcaggcac      600

caccactcgg agcacagggt ccatggtgcc atggagctgc aggtgcagac aggcaaagat      660

gcaccatcca actgtgtggt gtacccatcc tcctcccagg atagtgaaaa catcacggct      720

gcagccctgg ctacgggtgc ctgcatcgta ggaatcctct gcctccccct catcctgctc      780

ctggtctaca agcaaaggca ggcagcctcc aaccgccgtg cccaggagct ggtgcggatg      840

gacagcaaca ttcaagggat tgaaaacccc ggctttgaag cctcaccacc tgcccagggg      900

atacccgagg ccaaagtcag gcaccccctg tcctatgtgg cccagcggca gccttctgag      960

tctgggcggc atctgctttc ggagcccagc acccccctgt ctcctccagg ccccggagac     1020

gtcttcttcc catccctgga ccctgtccct gactctccaa actttgaggt catctagccc     1080

agctggggga cagtgggctg ttgtggctgg gtctggggca ggtgcatttg agccagggct     1140

ggctctgtga gtggcctcct tggcctcggc cctggttccc tccctcctgc tctgggctca     1200

gatactgtga catcccagaa gcccagcccc tcaacccctc tggatgctac atggggatgc     1260

tggacggctc agcccctgtt ccaaggattt tggggtgctg agattctccc ctagagacct     1320

gaaattcacc agctacagat gccaaatgac ttacatctta agaagtctca gaacgtccag     1380

cccttcagca gctctcgttc tgagacatga gccttgggat gtggcagcat cagtgggaca     1440

agatggacac tgggccaccc tcccaggcac cagacacagg gcacggtgga gagacttctc     1500

ccccgtggcc gccttggctc ccccgttttg cccgaggctg ctcttctgtc agacttcctc     1560

tttgtaccac agtggctctg gggccaggcc tgcctgccca ctggccatcg ccaccttccc     1620

cagctgcctc ctaccagcag tttctctgaa gatctgtcaa caggttaagt caatctgggg     1680

cttccactgc ctgcattcca gtccccagag cttggtggtc ccgaaacggg aagtacatat     1740

tggggcatgg tggcctccgt gagcaaatgg tgtcttgggc aatctgaggc caggacagat     1800

gttgccccac ccactggaga tggtgctgag ggaggtgggt ggggccttct gggaaggtga     1860

gtggagaggg gcacctgccc cccgccctcc ccatccccta ctcccactgc tcagcgcggg     1920

ccattgcaag ggtgccacac aatgtcttgt ccaccctggg acacttctga gtatgaagcg     1980

ggatgctatt aaaaactaca tggggaaaca ggtgcaaacc ctggagatgg attgtaagag     2040

ccagtttaaa tctgcactct gctgctcctc ccccaccccc accttccact ccatacaatc     2100

tgggcctggt ggagtcttcg cttcagagcc attcggccag gtgcgggtga tgttcccatc     2160

tcctgcttgt gggcatgccc tggctttgtt tttatacaca taggcaaggt gagtcctctg     2220

tggaattgtg attgaaggat tttaaagcag gggaggagag tagggggcat ctctgtacac     2280

tctgggggta aaacagggaa ggcagtgcct gagcatgggg acaggtgagg tggggctggg     2340

cagaccccct gtagcgttta gcaggatggg ggccccaggt actgtggaga gcatagtcca     2400

gcctgggcat ttgtctccta gcagcctaca ctggctctgc tgagctgggc ctgggtgctg     2460

aaagccagga tttggggcta ggcgggaaga tgttcgccca attgcttggg gggttggggg     2520

gatggaaaag gggagcacct ctaggctgcc tggcagcagt gagccctggg cctgtggcta     2580

cagccaggga accccacctg gacacatggc cctgcttcta agccccccag ttaggcccaa     2640

aggaatggtc cactgagggc ctcctgctct gcctgggctg ggccaggggc tttgaggaga     2700

gggtaaacat aggcccggag atggggctga cacctcgagt ggccagaata tgcccaaacc     2760

ccggcttctc ccttgtccct aggcagaggg gggtcccttc ttttgttccc tctggtcacc     2820

acaatgcttg atgccagctg ccataggaag agggtgctgg ctggccatgg tggcacacac     2880

ctgtcctccc agcactttgc agggctgagg tggaaggacc gcttaagccc aggtgttcaa     2940

ggctgctgtg agctgtgttc gagccactac actccagcct ggggacggag caaaactttg     3000

cctcaaaaca aattttaaaa agaaagaaag aaggaaagag ggtatgtttt tcacaattca     3060

tgggggcctg catggcagga gtggggacag gacacctgct gttcctggag tcgaaggaca     3120

agcccacagc ccagattccg gttctcccaa ctcaggaaga gcatgccctg ccctctgggg     3180

aggctggcct ggccccagcc ctcagctgct gaccttgagg cagagacaac ttctaagaat     3240

ttggctgcca gaccccaggc ctggctgctg ctgtgtggag agggaggcgg cccgcagcag     3300

aacagccacc gcacttcctc ctcagcttcc tctggtgcgg ccctgccctc tcttctctgg     3360

acccttttac aactgaacgc atctgggctt cgtggtttcc tgttttcagc gaaatttact     3420

ctgagctccc agttccatct tcatccatgg ccacaggccc tgcctacaac gcactaggga     3480

cgtccctccc tgctgctgct ggggaggggc aggctgctgg agccgccctc tgagttgccc     3540

gggatggtag tgcctctgat gccagccctg gtggctgtgg gctggggtgc atgggagagc     3600

tgggtgcgag aacatggcgc ctccaggggg cgggaggagc actaggggct ggggcaggag     3660

gctcctggag cgctggattc gtggcacagt ctgaggccct gagagggaaa tccatgcttt     3720

taagaactaa ttcattgtta ggagatcaat caggaattag gggccatctt acctatctcc     3780

tgacattcac agtttaatag agacttcctg cctttattcc ctcccaggga gaggctgaag     3840

gaatggaatt gaaagcacca tttggagggt tttgctgaca cagcggggac tgctcagcac     3900

tccctaaaaa cacaccatgg aggccactgg tgactgctgg tgggcaggct ggccctgcct     3960

gggggagtcc gtggcgatgg gcgctggggt ggaggtgcag gagccccagg acctgctttt     4020

caaaagactt ctgcctgacc agagctccca ctacatgcag tggcccaggg cagaggggct     4080

gatacatggc ctttttcagg gggtgctcct cgcggggtgg acttgggagt gtgcagtggg     4140

acagggggct gcaggggtcc tgccaccacc gagcaccaac ttggcccctg gggtcctgcc     4200

tcatgaatga ggccttcccc agggctggcc tgactgtgct gggggctggg ttaacgtttt     4260

ctcagggaac cacaatgcac gaaagaggaa ctggggttgc taaccaggat gctgggaaca     4320

aaggcctctt gaagcccagc cacagcccag ctgagcatga ggcccagccc atagacggca     4380

caggccacct ggcccattcc ctgggcattc cctgctttgc attgctgctt ctcttcaccc     4440

catggaggct atgtcaccct aactatcctg gaatgtgttg agagggattc tgaatgatca     4500

atatagcttg gtgagacagt gccgagatag atagccatgt ctgccttggg cacgggagag     4560

ggaagtggca gcatgcatgc tgtttcttgg ccttttctgt tagaatactt ggtgctttcc     4620

aacacacttt cacatgtgtt gtaacttgtt tgatccaccc ccttccctga aaatcctggg     4680

aggttttatt gctgccattt aacacagagg gcaatagagg ttctgaaagg tctgtgtctt     4740

gtcaaaacaa gtaaacggtg gaactacgac taaa                                 4774


<210>  20
<211>  3816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VISTA cDNA nucleotide sequence (mouse)

<400>  20
catgaaggag ggcggagctg ggaggctgca aggctgctgt ggatctaggg aagaggaacc       60

acagaaaagc taaaggagtc acctctgtct ggtagcagcc ttcaaggtca ccactccata      120

ttctctctat gtgtgtcccg agggacagaa tgccaccctc acctgcagga ttctgggccc      180

cgtgtccaaa gggcacgatg tgaccatcta caagacgtgg tacctcagct cacgaggcga      240

ggtccagatg tgcaaagaac accggcccat acgcaacttc acattgcagc accttcagca      300

ccacggaagc cacctgaaag ccaacgccag ccatgaccag ccccagaagc atgggctaga      360

gctagcttct gaccaccacg gtaacttctc tatcaccctg cgcaatgtga ccccaaggga      420

cagcggcctc tactgctgtc tagtgataga attaaaaaac caccacccag aacaacggtt      480

ctacgggtcc atggagctac aggtacaggc aggcaaaggc tcggggtcca catgcatggc      540

gtctaatgag caggacagtg acagcatcac ggctgcggcc ctggccaccg gcgcctgcat      600

cgtgggaatc ctctgcctcc cccttatcct gctgctggtc tataagcaga gacaggtggc      660

ctctcaccgc cgtgcccagg agttggtgag gatggacagc aacacccaag gaatcgaaaa      720

cccaggcttc gagaccactc cacccttcca ggggatgcct gaggccaaga ccaggccgcc      780

actgtcctat gtggcccagc ggcaaccttc ggagtcagga cggtacctgc tctctgaccc      840

cagcacacct ctgtcgcctc caggccctgg ggacgtcttt ttcccatccc tagatccagt      900

ccctgactcc cctaactctg aagccatcta aaccagctgg ggaaccatga accatggtac      960

ctgggtcagg gatatgtgca cttgatctat ggctggccct tggacagtct tttaggcact     1020

gactccagct tccttgctcc tgctctgagc ctagactctg cttttacaag atgcacagac     1080

cctcccctat ctctttcaga cgctacttgg ggggcaggga gaagatgttg gattgctcat     1140

tgctgttctc aagatcttgg gatgctgagt tctccctaga gacttgactt cgacagccac     1200

agatgtcaga tgacctgcat cctatgaacg tccggcttgg caagagcctt tcttcatgga     1260

aaccagtagc ccggagggga tgagggaact tggagccaca acatggaagg gacctgggct     1320

gacaattgtc acaggaaagg ccacccactg gacacctgcc acactgctgg ctcagaagtc     1380

tttgccatat gcatatccca tgaggactgc acacttggag gtgaaggtga agctgccggt     1440

ctgcctcaag gacagggacc cacatgtgga acttgtggtg ctggctcaag ttgggccttc     1500

cattgccagg cttctactgg aatatacgtc aacgactacc cttcaaagcc accccactaa     1560

aagccatggc tcctgggatc tgactcatgg tagcaagtct caggacaccc cacactccag     1620

atttcttcat caggactgtg tgattaagca tcttctatta ttcttttttc cacgggactg     1680

gctgcagatg aacgtgaccc agtgtcaatg agggtcctgc acatggtagc tgacaataac     1740

cagatgcccc cagagacttc cctggtttgt tatggatgcc tgggaagctg acactggccc     1800

ctcccccaaa tgtatgtacc aaggctgtac ctgccatgat gttctccagc acagacacga     1860

agtaggccgg cttgctgaag gtgggagggt tgtcgttctc atcctggaag gaaagcacat     1920

ggatcagcat gtcgggaagg tactcggcca actttgggta aaagtaggaa ccgaggggca     1980

gtttgggaag ggtggccctg agggtctctg gcctctatgt atcaccagag gctagggtat     2040

tatgaaagcc aggagtccct ctgccaggtc agttgaagga taggttgggt ggtctttggg     2100

gaagcatgta agggttgggg cgggggatga aatgagattt agagacagac actgagtaag     2160

agagcagtca gctcgtctcc agctcccagt ctcccaccta acagctgcac tccaagctta     2220

ctccagaggc ccagtccctt agttctttcg ttcctatcca gcgtccacct gatctctccc     2280

agctgagtca agacacagtg aaaggttcta gaagctctgc tagaatgaag agagagggct     2340

ggagagatgg cttaatggtc aagagcactg gctgctggtc cagaggactt gggttcaatt     2400

cccagcatct acaactctct gtaacttcag ttcccaggga tctgatgcct ttttctggcc     2460

tctgccattt ggcactcagc tggtacagag acaatccatt catgtaagca aaacacccaa     2520

tcacatatat ttttttaatt aatttaaaaa aggtgaggaa gaggattcaa gagagggctc     2580

agcagtaaag aacactgtct gctcttccag aggttcccgg ttgaatccca gcacccacat     2640

ggcagatcac aactatctgt aatttcagtt ccaggggatc tggtaccctt gcacagacat     2700

acaatgcagg gaaaacatca atgtacattt aaaaaaatct ttttttaaag ggcgaaggag     2760

aaaggcacat ctagtagcac agatatgaaa gtgtacaggg gcaggtagtg gtcaggctgg     2820

tcccagagcc tggactggct gtagctgggg ttggacagcc agcttggtct accagcttcg     2880

catcctctgg atcaccctgg tctgcagcct ggtacctgcc agttccttcc tttggctcag     2940

cctgcagcag ctagggatgg gagtgggaag cctggctgag gggctagacc aggtagagat     3000

gagccctgtg ttggggagaa cccgtgccag gtgcagccca cagctcccta gactcttcaa     3060

tcagagaagc aagcctccca tctttgggac tctcaccaga gccaacttct gccatcgctc     3120

accgggaatt cctcccagtt gccttcttca ctgaagacgc tctggctccc ctgactccag     3180

ctcaactccg tgctcccctc ctcagctcaa cagagcattg gaggagctca ggagctggct     3240

gagtgttccg cctttctccc catgttgcaa tattcaatgg gccccactac taggtcctca     3300

gagctcaggg acctggagac tcctccaggg gacagagttt gcatttgctg aactcttttg     3360

ctacggtttc ttctgcatga gcaagcagga aaaggatgag accatgctgc ttggcccgcc     3420

tctccccaga ctcgggacat ccccagcctg ctgcatggtg tgttcccaga attgatttgc     3480

tccatttctt cccaaatctg tcccctcgct ctgtcctgcg tacaggctca ctcccttccc     3540

aaggagctgg gagctttggg agtctcctga cacccaaggt ccccacaggt cacccaggac     3600

ctcacccagg ctgctggcat gagctcaagt gctttgggta tacactggga ggcttctgct     3660

cagctgcacg aagcaacgca gagaatgtca gctacggagc acgaggcaga aacttattag     3720

cggtgatatt tccccggatt ctggcgctgt acttgctatt agttctaatt cagtggctcc     3780

ctctataaaa gcttattgtc ccctaatggg aaatct                               3816


<210>  21
<211>  2471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full length COMP cDNA nucleotide sequence (human)

<400>  21
agaaagcgag cagccaccca gctccccgcc accgccatgg tccccgacac cgcctgcgtt       60

cttctgctca ccctggctgc cctcggcgcg tccggacagg gccagagccc gttgggctca      120

gacctgggcc cgcagatgct tcgggaactg caggaaacca acgcggcgct gcaggacgtg      180

cgggagctgc tgcggcagca ggtcagggag atcacgttcc tgaaaaacac ggtgatggag      240

tgtgacgcgt gcgggatgca gcagtcagta cgcaccggcc tacccagcgt gcggcccctg      300

ctccactgcg cgcccggctt ctgcttcccc ggcgtggcct gcatccagac ggagagcggc      360

gcgcgctgcg gcccctgccc cgcgggcttc acgggcaacg gctcgcactg caccgacgtc      420

aacgagtgca acgcccaccc ctgcttcccc cgagtccgct gtatcaacac cagcccgggg      480

ttccgctgcg aggcttgccc gccggggtac agcggcccca cccaccaggg cgtggggctg      540

gctttcgcca aggccaacaa gcaggtttgc acggacatca acgagtgtga gaccgggcaa      600

cataactgcg tccccaactc cgtgtgcatc aacacccggg gctccttcca gtgcggcccg      660

tgccagcccg gcttcgtggg cgaccaggcg tccggctgcc agcggcgcgc acagcgcttc      720

tgccccgacg gctcgcccag cgagtgccac gagcatgcag actgcgtcct agagcgcgat      780

ggctcgcggt cgtgcgtgtg tgccgttggc tgggccggca acgggatcct ctgtggtcgc      840

gacactgacc tagacggctt cccggacgag aagctgcgct gcccggagcg ccagtgccgt      900

aaggacaact gcgtgactgt gcccaactca gggcaggagg atgtggaccg cgatggcatc      960

ggagacgcct gcgatccgga tgccgacggg gacggggtcc ccaatgaaaa ggacaactgc     1020

ccgctggtgc ggaacccaga ccagcgcaac acggacgagg acaagtgggg cgatgcgtgc     1080

gacaactgcc ggtcccagaa gaacgacgac caaaaggaca cagaccagga cggccggggc     1140

gatgcgtgcg acgacgacat cgacggcgac cggatccgca accaggccga caactgccct     1200

agggtaccca actcagacca gaaggacagt gatggcgatg gtatagggga tgcctgtgac     1260

aactgtcccc agaagagcaa cccggatcag gcggatgtgg accacgactt tgtgggagat     1320

gcttgtgaca gcgatcaaga ccaggatgga gacggacatc aggactctcg ggacaactgt     1380

cccacggtgc ctaacagtgc ccaggaggac tcagaccacg atggccaggg tgatgcctgc     1440

gacgacgacg acgacaatga cggagtccct gacagtcggg acaactgccg cctggtgcct     1500

aaccccggcc aggaggacgc ggacagggac ggcgtgggcg acgtgtgcca ggacgacttt     1560

gatgcagaca aggtggtaga caagatcgac gtgtgtccgg agaacgctga agtcacgctc     1620

accgacttca gggccttcca gacagtcgtg ctggacccgg agggtgacgc gcagattgac     1680

cccaactggg tggtgctcaa ccagggaagg gagatcgtgc agacaatgaa cagcgaccca     1740

ggcctggctg tgggttacac tgccttcaat ggcgtggact tcgagggcac gttccatgtg     1800

aacacggtca cggatgacga ctatgcgggc ttcatctttg gctaccagga cagctccagc     1860

ttctacgtgg tcatgtggaa gcagatggag caaacgtatt ggcaggcgaa ccccttccgt     1920

gctgtggccg agcctggcat ccaactcaag gctgtgaagt cttccacagg ccccggggaa     1980

cagctgcgga acgctctgtg gcatacagga gacacagagt cccaggtgcg gctgctgtgg     2040

aaggacccgc gaaacgtggg ttggaaggac aagaagtcct atcgttggtt cctgcagcac     2100

cggccccaag tgggctacat cagggtgcga ttctatgagg gccctgagct ggtggccgac     2160

agcaacgtgg tcttggacac aaccatgcgg ggtggccgcc tgggggtctt ctgcttctcc     2220

caggagaaca tcatctgggc caacctgcgt taccgctgca atgacaccat cccagaggac     2280

tatgagaccc atcagctgcg gcaagcctag ggaccagggt gaggacccgc cggatgacag     2340

ccaccctcac cgcggctgga tgggggctct gcacccagcc ccaaggggtg gccgtcctga     2400

gggggaagtg agaagggctc agagaggaca aaataaagtg tgtgtgcagg gaaaaaaaaa     2460

aaaaaaaaaa a                                                          2471


<210>  22
<211>  2447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COMP cDNA nucleotide sequence (mouse)

<400>  22
gacagcagct gcagctccgc cgccatgggc cccactgcct gcgttctagt gctcgccctg       60

gctatcctgc gggcgacagg ccagggccag atcccgctgg gtggagacct ggccccacag      120

atgctgcgag aacttcagga gactaatgcg gcgctgcaag acgtgagaga gctgttgcga      180

cagcaggtca aggagatcac cttcctgaag aatacggtga tggaatgtga tgcttgcgga      240

atgcagcccg cacgcactcc aggcctgagc gtgcggccag tgccgctctg cgcacccggc      300

tcctgcttcc ccggcgtagt ctgctccgag acagctacgg gcgcgcgctg cggcccctgc      360

cctcctggct acaccggcaa cggctcgcac tgcaccgacg ttaatgagtg caatgctcac      420

ccctgtttcc cgcgggtgcg gtgcatcaat accagccctg gctttcactg cgaagcctgt      480

ccccctgggt tcagcggacc cacccacgag ggcgtgggac tgaccttcgc taagtccaac      540

aaacaagttt gcacggatat taatgagtgt gagaccgggc agcacaattg cgttcccaac      600

tccgtgtgcg tcaacacccg gggctccttc cagtgcggcc cctgccagcc cggtttcgtg      660

ggcgaccaga cgtcaggctg ccagcggcgt gggcagcact tctgccccga tgggtcaccc      720

agcccgtgcc atgagaaagc aaactgcgtc ctggagcggg atggctcgag gtcttgcgtg      780

tgtgcagttg gctgggccgg caacgggctc ctgtgcggcc gcgacacgga cctggacggt      840

tttcctgacg agaagcttcg ctgctcagag cgccagtgtc gcaaggacaa ctgcgtgacg      900

gtgcccaatt cggggcagga ggatgtggac cgggacggca tcggagatgc ttgtgacccg      960

gatgcggacg gggatggagt ccctaacgag caagacaatt gcccgctggt tcgaaaccca     1020

gaccagcgta actcggacag tgataagtgg ggagatgcct gcgacaactg ccggtccaag     1080

aagaatgacg atcagaaaga tacagacctg gatggccggg gcgatgcctg cgacgacgac     1140

atagatggcg accgaatacg aaatgtagct gacaactgtc cccgggtgcc caactttgac     1200

cagagtgaca gtgatggtga tggtgttggg gatgcctgtg acaactgtcc ccagaaagat     1260

aacccagacc agagggatgt ggaccacgac tttgtgggtg atgcctgtga tagtgaccaa     1320

gaccaggatg gggatggtca ccaggactcc cgggacaact gccccacagt acccaacagt     1380

gcccagcagg actcagatca tgatggcaag ggcgatgcct gtgatgacga tgatgacaat     1440

gacggagttc ctgatagccg ggacaactgc cgcttggtgc ctaaccctgg ccaagaggac     1500

aatgaccggg atggcgtggg tgacgcgtgt cagggtgact tcgatgctga caaggttata     1560

gacaagatcg atgtgtgccc cgagaacgcc gaggtcaccc tcaccgactt cagggccttc     1620

cagacggttg tgttggaccc cgagggtgat gcgcagatcg atcccaactg ggtggtgctc     1680

aatcagggaa tggagatcgt tcagaccatg aacagtgacc ctggcctggc tgtgggttac     1740

acagccttca acggcgtgga cttcgagggc acattccatg taaacaccgc cactgatgat     1800

gactatgctg gtttcatctt cggctaccaa gacagctcca gtttctacgt agtcatgtgg     1860

aaacagatgg agcagacgta ctggcaggcc aatcccttcc gggctgtggc tgagccaggg     1920

attcagctca aggctgtcaa gtcctctaca ggtcccgggg aacagctccg aaacgcactg     1980

tggcacacgg gggacacagc atcccaggtg cggctgctgt ggaaggatcc tcgaaacgtg     2040

ggctggaagg ataaaacatc ctaccgctgg ttcctgcagc accggcctca agttggctac     2100

atcagggtgc ggttctatga gggtcctgag ctagtagctg acagcaatgt ggtgttggac     2160

acggccatgc gtggtggccg cctgggtgtc ttctgcttct cccaagagaa catcatctgg     2220

gctaacctgc gctaccgttg caatgataca atccctgagg actacgagag tcaccggctg     2280

cagagagtct agggaccagt ggggtcccgc tgcctgatgg actgtggtgg cacaagctac     2340

gggtgtgtgt gtgggggggt ctggcatccc tctgaagggg tgtctggcct ggggaggaga     2400

ggcaaataaa gtacgtatgt gggggaaaaa aaaaaaaaaa aaaaaaa                   2447


<210>  23
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized VISTA.COMP DNA sequence (human)

<400>  23
atggaaaccg acacactgct gctgtgggtg ctgcttcttt gggtgcccgg aagcaccggc       60

gagttcaaag tggccacacc ttacagcctg tacgtgtgcc ctgagggcca gaatgtgacc      120

ctgacctgta gactgctggg ccccgtggat aagggccacg acgtgacctt ttacaagacc      180

tggtacagat ccagcagagg cgaggtgcag acctgctctg agagaaggcc catccggaac      240

ctgaccttcc aggacctgca tctgcaccac ggtggacatc aggccgccaa tacctctcat      300

gatctggccc agagacacgg cctggaaagc gcctctgatc accacggcaa cttcagcatc      360

accatgcgga atctgaccct gctggacagc ggcctgtact gctgtctggt ggtggaaatc      420

agacaccacc acagcgagca cagagtgcac ggcgctatgg aactgcaggt ccagacaggc      480

aaggacgccc ctagcaattg cgtggtgtac cctagcagca gccaggacag cgagaatatc      540

accgccgagt ttggctctgg ccctggacct tctggaacag atctgggccc tcagatgctg      600

agagagctgc aagagacaaa cgccgctctg caggatgtgc gcgagctgct gagacagcaa      660

gtgcgcgaga tcaccttcct gaagaacacc gtgatggaat gcgacgcctg tggcggatct      720

cctcagcctc agagcgagaa cctgtacttc caaggcggcc ctcaacctca aggcggctct      780

ggatctggaa gcggaggcag acaccatcac catcatcacc accactga                   828


<210>  24
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VISTA.COMP amino acid sequence (human)

<400>  24

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val 
            20                  25                  30          


Cys Pro Glu Gly Gln Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro 
        35                  40                  45              


Val Asp Lys Gly His Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser 
    50                  55                  60                  


Ser Arg Gly Glu Val Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn 
65                  70                  75                  80  


Leu Thr Phe Gln Asp Leu His Leu His His Gly Gly His Gln Ala Ala 
                85                  90                  95      


Asn Thr Ser His Asp Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser 
            100                 105                 110         


Asp His His Gly Asn Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu 
        115                 120                 125             


Asp Ser Gly Leu Tyr Cys Cys Leu Val Val Glu Ile Arg His His His 
    130                 135                 140                 


Ser Glu His Arg Val His Gly Ala Met Glu Leu Gln Val Gln Thr Gly 
145                 150                 155                 160 


Lys Asp Ala Pro Ser Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp 
                165                 170                 175     


Ser Glu Asn Ile Thr Ala Glu Phe Gly Ser Gly Pro Gly Pro Ser Gly 
            180                 185                 190         


Thr Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala 
        195                 200                 205             


Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile 
    210                 215                 220                 


Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly Gly Ser 
225                 230                 235                 240 


Pro Gln Pro Gln Ser Glu Asn Leu Tyr Phe Gln Gly Gly Pro Gln Pro 
                245                 250                 255     


Gln Gly Gly Ser Gly Ser Gly Ser Gly Gly Arg His His His His His 
            260                 265                 270         


His His His 
        275 


<210>  25
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-H4 extracellular domain amino acid sequence (human)

<400>  25

Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly 
1               5                   10                  15      


Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile 
            20                  25                  30          


Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly 
        35                  40                  45              


Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp 
    50                  55                  60                  


Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val 
65                  70                  75                  80  


Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly 
                85                  90                  95      


Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn 
            100                 105                 110         


Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp 
        115                 120                 125             


Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe 
    130                 135                 140                 


Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn 
145                 150                 155                 160 


Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val 
                165                 170                 175     


Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr 
            180                 185                 190         


Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile 
        195                 200                 205             


Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu 
    210                 215                 220                 


Asn Ser Lys Ala Ser 
225                 


<210>  26
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-H4 extracellular domain cDNA sequence (human)

<400>  26
atttcaggga gacactccat cacagtcact actgtcgcct cagctgggaa cattggggag       60

gatggaatcc tgagctgcac ttttgaacct gacatcaaac tttctgatat cgtgatacaa      120

tggctgaagg aaggtgtttt aggcttggtc catgagttca aagaaggcaa agatgagctg      180

tcggagcagg atgaaatgtt cagaggccgg acagcagtgt ttgctgatca agtgatagtt      240

ggcaatgcct ctttgcggct gaaaaacgtg caactcacag atgctggcac ctacaaatgt      300

tatatcatca cttctaaagg caaggggaat gctaaccttg agtataaaac tggagccttc      360

agcatgccgg aagtgaatgt ggactataat gccagctcag agaccttgcg gtgtgaggct      420

ccccgatggt tcccccagcc cacagtggtc tgggcatccc aagttgacca gggagccaac      480

ttctcggaag tctccaatac cagctttgag ctgaactctg agaatgtgac catgaaggtt      540

gtgtctgtgc tctacaatgt tacgatcaac aacacatact cctgtatgat tgaaaatgac      600

attgccaaag caacagggga tatcaaagtg acagaatcgg agatcaaaag gcggagtcac      660

ctacagctgc taaactcaaa ggcttct                                          687


<210>  27
<211>  687
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  B7-H4 extracellular domain mRNA sequence (human)

<400>  27
auuucaggga gacacuccau cacagucacu acugucgccu cagcugggaa cauuggggag       60

gauggaaucc ugagcugcac uuuugaaccu gacaucaaac uuucugauau cgugauacaa      120

uggcugaagg aagguguuuu aggcuugguc caugaguuca aagaaggcaa agaugagcug      180

ucggagcagg augaaauguu cagaggccgg acagcagugu uugcugauca agugauaguu      240

ggcaaugccu cuuugcggcu gaaaaacgug caacucacag augcuggcac cuacaaaugu      300

uauaucauca cuucuaaagg caaggggaau gcuaaccuug aguauaaaac uggagccuuc      360

agcaugccgg aagugaaugu ggacuauaau gccagcucag agaccuugcg gugugaggcu      420

ccccgauggu ucccccagcc cacagugguc ugggcauccc aaguugacca gggagccaac      480

uucucggaag ucuccaauac cagcuuugag cugaacucug agaaugugac caugaagguu      540

gugucugugc ucuacaaugu uacgaucaac aacacauacu ccuguaugau ugaaaaugac      600

auugccaaag caacagggga uaucaaagug acagaaucgg agaucaaaag gcggagucac      660

cuacagcugc uaaacucaaa ggcuucu                                          687


<210>  28
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-H4 full length amino acid sequence (human)

<400>  28

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  29
<211>  849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-H4 full length cDNA nucleotide sequence (human)

<400>  29
atggcttccc tggggcagat cctcttctgg agcataatta gcatcatcat tattctggct       60

ggagcaattg cactcatcat tggctttggt atttcaggga gacactccat cacagtcact      120

actgtcgcct cagctgggaa cattggggag gatggaatcc tgagctgcac ttttgaacct      180

gacatcaaac tttctgatat cgtgatacaa tggctgaagg aaggtgtttt aggcttggtc      240

catgagttca aagaaggcaa agatgagctg tcggagcagg atgaaatgtt cagaggccgg      300

acagcagtgt ttgctgatca agtgatagtt ggcaatgcct ctttgcggct gaaaaacgtg      360

caactcacag atgctggcac ctacaaatgt tatatcatca cttctaaagg caaggggaat      420

gctaaccttg agtataaaac tggagccttc agcatgccgg aagtgaatgt ggactataat      480

gccagctcag agaccttgcg gtgtgaggct ccccgatggt tcccccagcc cacagtggtc      540

tgggcatccc aagttgacca gggagccaac ttctcggaag tctccaatac cagctttgag      600

ctgaactctg agaatgtgac catgaaggtt gtgtctgtgc tctacaatgt tacgatcaac      660

aacacatact cctgtatgat tgaaaatgac attgccaaag caacagggga tatcaaagtg      720

acagaatcgg agatcaaaag gcggagtcac ctacagctgc taaactcaaa ggcttctctg      780

tgtgtctctt ctttctttgc catcagctgg gcacttctgc ctctcagccc ttacctgatg      840

ctaaaataa                                                              849


<210>  30
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-H4.COMP amino acid sequence (human B7-H4.COMP)

<400>  30

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Glu Phe Gly Ser Gly Pro 
                245                 250                 255     


Gly Pro Ser Gly Thr Asp Leu Ala Pro Gln Met Leu Arg Glu Leu Gln 
            260                 265                 270         


Glu Thr Asn Ala Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln 
        275                 280                 285             


Val Lys Glu Ile Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala 
    290                 295                 300                 


Cys Gly Gly Ser Pro Gln Pro Gln Ser Glu Asn Leu Tyr Phe Gln Gly 
305                 310                 315                 320 


Gly Pro Gln Pro Gln Gly Gly Ser Gly Ser Gly Ser Gly Gly Arg His 
                325                 330                 335     


His His His His His His His 
            340             


<210>  31
<211>  1035
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-H4.COMP codon optimized DNA sequence (human B7-H4)

<400>  31
atggagacag atacactcct gctctgggtc ctcctgctgt gggtgcctgg aagcacggga       60

ttcggcattt cagggcggca cagcatcaca gtcactacgg tagcgagtgc cgggaatatt      120

ggggaagacg gaatcctttc atgtaccttc gaacccgaca taaagttgtc agatatcgtg      180

atccaatggc ttaaagaagg agtcttggga ctcgttcacg agtttaagga aggcaaagat      240

gaactcagtg aacaagacga gatgtttagg ggacggacag cggtgtttgc tgatcaggtc      300

attgtcggca atgccagcct gcgccttaaa aatgttcagc tcaccgatgc ggggacctat      360

aagtgttata ttatcacgtc caagggcaag ggtaacgcga acctcgagta caaaacagga      420

gctttttcta tgcctgaagt gaatgtagac tataatgctt caagcgaaac tcttcgatgc      480

gaagcgccac gctggtttcc gcagcccact gtagtgtggg cgtcccaagt cgatcaggga      540

gcaaacttca gcgaggtgtc aaacacgtca tttgagctta actctgagaa cgtaaccatg      600

aaagtggtaa gcgtgttgta taatgtcaca atcaataata cttattcctg tatgatcgaa      660

aacgatatcg ctaaagcaac cggcgacatc aaagttacgg aatccgagat taagcgccgc      720

tcacacttgc aactccttaa ttccaaggcc gaattcgggt ccggccccgg tcctagcggg      780

actgacctgg ctccgcaaat gcttagggag cttcaggaaa caaatgccgc cttgcaagac      840

gtgcgagaac tgctgagaca acaggttaag gagatcacat tcctgaagaa tacagttatg      900

gaatgtgatg cctgcggggg gtcccctcag ccccagtctg aaaatttgta tttccagggg      960

ggtccacagc cccaaggtgg ttcaggctca ggctcaggtg gccggcacca tcatcatcat     1020

caccaccact aatga                                                      1035


<210>  32
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-H4.COMP amino acid sequence (mouse)

<400>  32

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Phe Gly Leu Ile Ile Gly Phe Gly Ile Ser Gly Lys 
            20                  25                  30          


His Phe Ile Thr Val Thr Thr Phe Thr Ser Ala Gly Asn Ile Gly Glu 
        35                  40                  45              


Asp Gly Thr Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Asn Gly 
    50                  55                  60                  


Ile Val Ile Gln Trp Leu Lys Glu Gly Ile Lys Gly Leu Val His Glu 
65                  70                  75                  80  


Phe Lys Glu Gly Lys Asp Asp Leu Ser Gln Gln His Glu Met Phe Arg 
                85                  90                  95      


Gly Arg Thr Ala Val Phe Ala Asp Gln Val Val Val Gly Asn Ala Ser 
            100                 105                 110         


Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Thr Cys 
        115                 120                 125             


Tyr Ile Arg Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys 
    130                 135                 140                 


Thr Gly Ala Phe Ser Met Pro Glu Ile Asn Val Asp Tyr Asn Ala Ser 
145                 150                 155                 160 


Ser Glu Ser Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr 
                165                 170                 175     


Val Ala Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser Glu Val 
            180                 185                 190         


Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val 
        195                 200                 205             


Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser Cys Met 
    210                 215                 220                 


Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Asp 
225                 230                 235                 240 


Ser Glu Val Lys Arg Arg Ser Gln Leu Gln Leu Leu Asn Ser Gly Glu 
                245                 250                 255     


Phe Gly Ser Gly Pro Gly Pro Ser Gly Thr Asp Leu Ala Pro Gln Met 
            260                 265                 270         


Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg Glu 
        275                 280                 285             


Leu Leu Arg Gln Gln Val Lys Glu Ile Thr Phe Leu Lys Asn Thr Val 
    290                 295                 300                 


Met Glu Cys Asp Ala Cys Gly Gly Ser Pro Gln Pro Gln Ser Glu Asn 
305                 310                 315                 320 


Leu Tyr Phe Gln Gly Gly Pro Gln Pro Gln Gly Gly Ser Gly Ser Gly 
                325                 330                 335     


Ser Gly Gly Arg His His His His His His His His 
            340                 345             


<210>  33
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized B7-H4.COMP DNA sequence (mouse)

<400>  33
atggaaaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

gaattcctga tcatcggctt tggcatcagc ggcaagcact tcatcaccgt gaccaccttt      120

accagcgccg gcaacatcgg cgaggatggc acactgagct gcaccttcga gcccgacatc      180

aagctgaacg gcatcgtgat ccagtggctg aaagagggca tcaaaggcct ggtgcacgag      240

ttcaaagaag gcaaggacga cctgagccag cagcacgaga tgttcagagg cagaaccgcc      300

gtgttcgccg atcaggtggt cgtgggaaat gccagcctgc ggctgaagaa tgtgcagctg      360

acagacgccg gcacctacac ctgttacatc cggacctcta aaggcaaggg caacgccaac      420

ctcgagtaca agacaggcgc cttcagcatg cccgagatca acgtggacta caacgccagc      480

agcgagagcc tgagatgcga agcccctaga tggttccctc agcctacagt ggcttgggct      540

agtcaggttg accagggcgc caactttagc gaggtgtcca acaccagctt cgagctgaac      600

agcgagaacg tgaccatgaa ggtggtgtcc gtgctgtaca atgtgaccat caacaacacc      660

tacagctgca tgatcgagaa cgatatcgcc aaggccaccg gcgacatcaa agtgaccgac      720

agcgaagtga agcggcggag ccaactgcag ctgctgaatt ctggaggtac cgatctggcc      780

ccccagatgc tgagagagct gcaggaaaca aacgccgccc tgcaggacgt gcgcgagctg      840

ctgagacagc aagtgaaaga gatcaccttc ctgaagaaca ccgtgatgga atgcgacgcc      900

tgcggcggct ctccacaacc acagtctgag aacctgtatt ttcaaggcgg cccacaacca      960

cagggcggat ccggctctgg ctctggcggc cgccaccacc atcatcacca tcaccactga     1020

tga                                                                   1023


<210>  34
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-H4 full length amino acid sequence (mouse)

<400>  34

Met Ala Ser Leu Gly Gln Ile Ile Phe Trp Ser Ile Ile Asn Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly Ile Lys Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser Gln Gln His Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Val Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Thr Cys Tyr Ile Arg Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Gly Pro Ser Pro Cys Val Phe Ser Ser Ala Phe Val Ala Gly Trp Ala 
            260                 265                 270         


Leu Leu Ser Leu Ser Cys Cys Leu Met Leu Arg 
        275                 280             


<210>  35
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-H4 full length cDNA nucleotide sequence (mouse)

<400>  35
atggcttcct tggggcagat catcttttgg agtattatta acatcatcat catcctggct       60

ggggccatcg cactcatcat tggctttggc atttcaggca agcacttcat cacggtcacg      120

accttcacct cagctggaaa cattggagag gacgggaccc tgagctgcac ttttgaacct      180

gacatcaaac tcaacggcat cgtcatccag tggctgaaag aaggcatcaa aggtttggtc      240

cacgagttca aagaaggcaa agacgacctc tcacagcagc atgagatgtt cagaggccgc      300

acagcagtgt ttgctgatca ggtggtagtt ggcaatgctt ccctgagact gaaaaacgtg      360

cagctcacgg atgctggcac ctacacatgt tacatccgca cctcaaaagg caaagggaat      420

gcaaaccttg agtataagac cggagccttc agtatgccag agataaatgt ggactataat      480

gccagttcag agagtttacg ctgcgaggct cctcggtggt tcccccagcc cacagtggcc      540

tgggcatctc aagtcgacca aggagccaat ttctcagaag tctccaacac cagctttgag      600

ttgaactctg agaatgtgac catgaaggtc gtatctgtgc tctacaatgt cacaatcaac      660

aacacatact cctgtatgat tgaaaacgac attgccaaag ccaccgggga catcaaagtg      720

acagattcag aggtcaaaag gcgaagtcag ctgcagttgc tgaactctgg gccttccccg      780

tgtgtttttt cttctgcctt tgtggctggc tgggcactcc tatctctctc ctgttgcctg      840

atgctaagat ga                                                          852


<210>  36
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 extracellular domain amino acid sequence (human)

<400>  36

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  37
<211>  662
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 extracellular domain cDNA nucleotide sequence (human)

<400>  37
catttactgt cacggttccc aaggacctat atgtggtaga gtatggtagc aatatgacaa       60

ttgaatgcaa attcccagta gaaaaacaat tagacctggc tgcactaatt gtctattggg      120

aaatggagga taagaacatt attcaatttg tgcatggaga ggaagacctg aaggttcagc      180

atagtagcta cagacagagg gcccggctgt tgaaggacca gctctccctg ggaaatgctg      240

cacttcagat cacagatgtg aaattgcagg atgcaggggt gtaccgctgc atgatcagct      300

atggtggtgc cgactacaag cgaattactg tgaaagtcaa tgccccatac aacaaaatca      360

accaaagaat tttggttgtg gatccagtca cctctgaaca tgaactgaca tgtcaggctg      420

agggctaccc caaggccgaa gtcatctgga caagcagtga ccatcaagtc ctgagtggta      480

agaccaccac caccaattcc aagagagagg agaagctttt caatgtgacc agcacactga      540

gaatcaacac aacaactaat gagattttct actgcacttt taggagatta gatcctgagg      600

aaaaccatac agctgaattg gtcatcccag aactacctct ggcacatcct ccaaatgaaa      660

gg                                                                     662


<210>  38
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 full length amino acid sequence (human)

<400>  38

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  39
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 full length nucleotide sequence (human)

<400>  39
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggactcac      720

ttggtaattc tgggagccat cttattatgc cttggtgtag cactgacatt catcttccgt      780

ttaagaaaag ggagaatgat ggatgtgaaa aaatgtggca tccaagatac aaactcaaag      840

aagcaaagtg atacacattt ggaggagacg taa                                   873


<210>  40
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1.COMP amino acid sequence (human)

<400>  40

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Phe Phe Thr Val Thr Val Pro Lys Asp Leu Tyr 
            20                  25                  30          


Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val 
        35                  40                  45              


Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu 
    50                  55                  60                  


Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val 
65                  70                  75                  80  


Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu 
                85                  90                  95      


Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp 
            100                 105                 110         


Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys 
        115                 120                 125             


Arg Ile Thr Val Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg 
    130                 135                 140                 


Ile Leu Val Val Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln 
145                 150                 155                 160 


Ala Glu Gly Tyr Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His 
                165                 170                 175     


Gln Val Leu Ser Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu 
            180                 185                 190         


Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn 
        195                 200                 205             


Glu Ile Phe Tyr Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His 
    210                 215                 220                 


Thr Ala Glu Leu Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn 
225                 230                 235                 240 


Glu Arg Gly Thr Asp Leu Ala Pro Gln Met Leu Arg Glu Leu Gln Glu 
                245                 250                 255     


Thr Asn Ala Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val 
            260                 265                 270         


Lys Glu Ile Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys 
        275                 280                 285             


Gly Gly Ser Pro Gln Pro Gln Ser Glu Asn Leu Tyr Phe Gln Gly Gly 
    290                 295                 300                 


Pro Gln Pro Gln Gly Gly Ser Gly Ser Gly Ser Gly Gly Arg His His 
305                 310                 315                 320 


His His His His His His 
                325     


<210>  41
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized PD-L1.COMP encoding nucleotide sequence (human)

<400>  41
atggaaaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

gaattcttca ccgtgaccgt gcctaaggac ctgtacgtgg tggaatacgg cagcaacatg      120

accatcgagt gcaagttccc cgtggaaaag cagctggatc tggccgctct gatcgtgtac      180

tgggagatgg aagataagaa catcatccag ttcgtgcacg gcgaagagga cctgaaggtg      240

cagcacagca gctacagaca gagagccaga ctgctgaagg accagctgag cctgggaaat      300

gccgctctgc agatcaccga cgtgaagctg caagatgccg gcgtgtaccg gtgcatgatc      360

tcttatggcg gagccgacta caagcggatc accgtgaaag tgaacgcccc ttacaacaag      420

atcaaccagc ggatcctggt ggtggaccct gtgacatctg agcacgagct gacctgtcag      480

gccgagggat atcctaaggc cgaagtgatc tggaccagca gcgatcacca ggtgctgagc      540

ggcaagacca ccaccacaaa cagcaagcgg gaagagaagc tgttcaacgt gaccagcaca      600

ctgcggatca acacaaccac caacgagatc ttctactgca cctttcggcg gctggacccc      660

gaggaaaatc acacagccga gctggtcatc cccgagctgc ctcttgctca ccctcctaac      720

gaaagaggta ccgatctggc cccccagatg ctgagagagc tgcaggaaac aaacgccgcc      780

ctgcaggacg tgcgcgagct gctgagacag caagtgaaag agatcacctt cctgaagaac      840

accgtgatgg aatgcgacgc ctgcggcggc tctccacaac cacagtctga gaacctgtat      900

tttcaaggcg gcccacaacc acagggcgga tccggctctg gctctggcgg ccgccaccac      960

catcatcacc atcaccactg atga                                             984


<210>  42
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 extracellular domain amino acid sequence (mouse)

<400>  42

Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu Asp Leu 
            20                  25                  30          


Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val Ile Gln 
        35                  40                  45              


Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn Phe Arg 
    50                  55                  60                  


Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Cys Cys 
                85                  90                  95      


Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp Pro Ala 
        115                 120                 125             


Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro Glu Ala 
    130                 135                 140                 


Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly Lys Arg 
145                 150                 155                 160 


Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val Thr Ser 
                165                 170                 175     


Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys Thr Phe 
            180                 185                 190         


Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile Ile Pro 
        195                 200                 205             


Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg 
    210                 215                 


<210>  43
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 extracellular domain cDNA nucleotide sequence (mouse)

<400>  43
tttactatca cggctccaaa ggacttgtac gtggtggagt atggcagcaa cgtcacgatg       60

gagtgcagat tccctgtaga acgggagctg gacctgcttg cgttagtggt gtactgggaa      120

aaggaagatg agcaagtgat tcagtttgtg gcaggagagg aggaccttaa gcctcagcac      180

agcaacttca gggggagagc ctcgctgcca aaggaccagc ttttgaaggg aaatgctgcc      240

cttcagatca cagacgtcaa gctgcaggac gcaggcgttt actgctgcat aatcagctac      300

ggtggtgcgg actacaagcg aatcacgctg aaagtcaatg ccccataccg caaaatcaac      360

cagagaattt ccgtggatcc agccacttct gagcatgaac taatatgtca ggccgagggt      420

tatccagaag ctgaggtaat ctggacaaac agtgaccacc aacccgtgag tgggaagaga      480

agtgtcacca cttcccggac agaggggatg cttctcaatg tgaccagcag tctgagggtc      540

aacgccacag cgaatgatgt tttctactgt acgttttgga gatcacagcc agggcaaaac      600

cacacagcgg agctgatcat cccagaactg cctgcaacac atcctccaca gaacagg         657


<210>  44
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1 full length amino acid sequence (mouse)

<400>  44

Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr His Trp 
225                 230                 235                 240 


Val Leu Leu Gly Ser Ile Leu Leu Phe Leu Ile Val Val Ser Thr Val 
                245                 250                 255     


Leu Leu Phe Leu Arg Lys Gln Val Arg Met Leu Asp Val Glu Lys Cys 
            260                 265                 270         


Gly Val Glu Asp Thr Ser Ser Lys Asn Arg Asn Asp Thr Gln Phe Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  45
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1 full length cDNA nucleotide sequence (mouse)

<400>  45
atgaggatat ttgctggcat tatattcaca gcctgctgtc acttgctacg ggcgtttact       60

atcacggctc caaaggactt gtacgtggtg gagtatggca gcaacgtcac gatggagtgc      120

agattccctg tagaacggga gctggacctg cttgcgttag tggtgtactg ggaaaaggaa      180

gatgagcaag tgattcagtt tgtggcagga gaggaggacc ttaagcctca gcacagcaac      240

ttcaggggga gagcctcgct gccaaaggac cagcttttga agggaaatgc tgcccttcag      300

atcacagacg tcaagctgca ggacgcaggc gtttactgct gcataatcag ctacggtggt      360

gcggactaca agcgaatcac gctgaaagtc aatgccccat accgcaaaat caaccagaga      420

atttccgtgg atccagccac ttctgagcat gaactaatat gtcaggccga gggttatcca      480

gaagctgagg taatctggac aaacagtgac caccaacccg tgagtgggaa gagaagtgtc      540

accacttccc ggacagaggg gatgcttctc aatgtgacca gcagtctgag ggtcaacgcc      600

acagcgaatg atgttttcta ctgtacgttt tggagatcac agccagggca aaaccacaca      660

gcggagctga tcatcccaga actgcctgca acacatcctc cacagaacag gactcactgg      720

gtgcttctgg gatccatcct gttgttcctc attgtagtgt ccacggtcct cctcttcttg      780

agaaaacaag tgagaatgct agatgtggag aaatgtggcg ttgaagatac aagctcaaaa      840

aaccgaaatg atacacaatt cgaggagacg taa                                   873


<210>  46
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-L1.COMP amino acid sequence (mouse)

<400>  46

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Phe Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr 
            20                  25                  30          


Val Val Glu Tyr Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val 
        35                  40                  45              


Glu Arg Glu Leu Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu 
    50                  55                  60                  


Asp Glu Gln Val Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro 
65                  70                  75                  80  


Gln His Ser Asn Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu 
                85                  90                  95      


Leu Lys Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp 
            100                 105                 110         


Ala Gly Val Tyr Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys 
        115                 120                 125             


Arg Ile Thr Leu Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg 
    130                 135                 140                 


Ile Ser Val Asp Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala 
145                 150                 155                 160 


Glu Gly Tyr Pro Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln 
                165                 170                 175     


Pro Val Ser Gly Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met 
            180                 185                 190         


Leu Leu Asn Val Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp 
        195                 200                 205             


Val Phe Tyr Cys Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr 
    210                 215                 220                 


Ala Glu Leu Ile Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn 
225                 230                 235                 240 


Arg Gly Thr Asp Leu Ala Pro Gln Met Leu Arg Glu Leu Gln Glu Thr 
                245                 250                 255     


Asn Ala Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Lys 
            260                 265                 270         


Glu Ile Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly 
        275                 280                 285             


Gly Ser Pro Gln Pro Gln Ser Glu Asn Leu Tyr Phe Gln Gly Gly Pro 
    290                 295                 300                 


Gln Pro Gln Gly Gly Ser Gly Ser Gly Ser Gly Gly Arg His His His 
305                 310                 315                 320 


His His His His His 
                325 


<210>  47
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-L1.COMP encoding nucleotide sequence (mouse)

<400>  47
atggaaaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

gaattcttta ctatcacggc tccaaaggac ttgtacgtgg tggagtatgg cagcaacgtc      120

acgatggagt gcagattccc tgtagaacgg gagctggacc tgcttgcgtt agtggtgtac      180

tgggaaaagg aagatgagca agtgattcag tttgtggcag gagaggagga ccttaagcct      240

cagcacagca acttcagggg gagagcctcg ctgccaaagg accagctttt gaagggaaat      300

gctgcccttc agatcacaga cgtcaagctg caggacgcag gcgtttactg ctgcataatc      360

agctacggtg gtgcggacta caagcgaatc acgctgaaag tcaatgcccc ataccgcaaa      420

atcaaccaga gaatttccgt ggatccagcc acttctgagc atgaactaat atgtcaggcc      480

gagggttatc cagaagctga ggtaatctgg acaaacagtg accaccaacc cgtgagtggg      540

aagagaagtg tcaccacttc ccggacagag gggatgcttc tcaatgtgac cagcagtctg      600

agggtcaacg ccacagcgaa tgatgttttc tactgtacgt tttggagatc acagccaggg      660

caaaaccaca cagcggagct gatcatccca gaactgcctg caacacatcc tccacagaac      720

aggggtaccg atctggcccc ccagatgctg agagagctgc aggaaacaaa cgccgccctg      780

caggacgtgc gcgagctgct gagacagcaa gtgaaagaga tcaccttcct gaagaacacc      840

gtgatggaat gcgacgcctg cggcggctct ccacaaccac agtctgagaa cctgtatttt      900

caaggcggcc cacaaccaca gggcggatcc ggctctggct ctggcggccg ccaccaccat      960

catcaccatc accactgatg a                                                981


<210>  48
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS-L extracellular domain cDNA nucleotide sequence (human)

<400>  48
gatactcagg agaaggaagt cagagcgatg gtaggcagcg acgtggagct cagctgcgct       60

tgccctgaag gaagccgttt tgatttaaat gatgtttacg tatattggca aaccagtgag      120

tcgaaaaccg tggtgaccta ccacatccca cagaacagct ccttggaaaa cgtggacagc      180

cgctaccgga accgagccct gatgtcaccg gccggcatgc tgcggggcga cttctccctg      240

cgcttgttca acgtcacccc ccaggacgag cagaagtttc actgcctggt gttgagccaa      300

tccctgggat tccaggaggt tttgagcgtt gaggttacac tgcatgtggc agcaaacttc      360

agcgtgcccg tcgtcagcgc cccccacagc ccctcccagg atgagctcac cttcacgtgt      420

acatccataa acggctaccc caggcccaac gtgtactgga tcaataagac ggacaacagc      480

ctgctggacc aggctctgca gaatgacacc gtcttcttga acatgcgggg cttgtatgac      540

gtggtcagcg tgctgaggat cgcacggacc cccagcgtga acattggctg ctgcatagag      600

aacgtgcttc tgcagcagaa cctgactgtc ggcagccaga caggaaatga catcggagag      660

agagacaaga tcacagagaa tccagtcagt accggcgaga aaaacgcggc cacgtggtcc      720


<210>  49
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS-L extracellular domain amino acid sequence (human)

<400>  49

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr Trp Ser 
225                 230                 235                 240 


<210>  50
<211>  1572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS-L full length cDNA nucleotide sequence (human)

<400>  50
gagtagagcc gatctcccgc gccccgaggt tgctcctctc cgaggtctcc cgcggcccaa       60

gttctccgcg ccccgaggtc tccgcgcccc gaggtctccg cggcccgagg tctccgcccg      120

caccatgcgg ctgggcagtc ctggactgct cttcctgctc ttcagcagcc ttcgagctga      180

tactcaggag aaggaagtca gagcgatggt aggcagcgac gtggagctca gctgcgcttg      240

ccctgaagga agccgttttg atttaaatga tgtttacgta tattggcaaa ccagtgagtc      300

gaaaaccgtg gtgacctacc acatcccaca gaacagctcc ttggaaaacg tggacagccg      360

ctaccggaac cgagccctga tgtcaccggc cggcatgctg cggggcgact tctccctgcg      420

cttgttcaac gtcacccccc aggacgagca gaagtttcac tgcctggtgt tgagccaatc      480

cctgggattc caggaggttt tgagcgttga ggttacactg catgtggcag caaacttcag      540

cgtgcccgtc gtcagcgccc cccacagccc ctcccaggat gagctcacct tcacgtgtac      600

atccataaac ggctacccca ggcccaacgt gtactggatc aataagacgg acaacagcct      660

gctggaccag gctctgcaga atgacaccgt cttcttgaac atgcggggct tgtatgacgt      720

ggtcagcgtg ctgaggatcg cacggacccc cagcgtgaac attggctgct gcatagagaa      780

cgtgcttctg cagcagaacc tgactgtcgg cagccagaca ggaaatgaca tcggagagag      840

agacaagatc acagagaatc cagtcagtac cggcgagaaa aacgcggcca cgtggagcat      900

cctggctgtc ctgtgcctgc ttgtggtcgt ggcggtggcc ataggctggg tgtgcaggga      960

ccgatgcctc caacacagct atgcaggtgc ctgggctgtg agtccggaga cagagctcac     1020

tggccacgtt tgaccggagc tcaccgccca gagcgtggac agggcttcca tgagacgcca     1080

ccgtgagagg ccaggtggca gcttgagcat ggactcccag actgcagggg agcacttggg     1140

gcagccccca gaaggaccac tgctggatcc cagggagaac ctgctggcgt tggctgtgat     1200

cctggaatga ggccctttca aaagcgtcat ccacaccaaa ggcaaatgtc cccaagtgag     1260

tgggctcccc gctgtcactg ccagtcaccc acaggaaggg actggtgatg ggctgtctct     1320

acccggagcg tgcgggattc agcaccaggc tcttcccagt accccagacc cactgtgggt     1380

cttcccgtgg gatgcgggat cctgagaccg aagggtgttt ggtttaaaaa gaagactggg     1440

cgtccgctct tccaggacgg cctctgtgct gctggggtca cgcgaggctg tttgcagggg     1500

acacggtcac aggagctctt ctgccctgaa cgcttccaac ctgctccggc cggaagccac     1560

aggacccact ca                                                         1572


<210>  51
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS-L full length amino acid sequence (human)

<400>  51

Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         


Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             


Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val 
    290                 295                 300         


<210>  52
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS-L extracellular domain cDNA nucleotide sequence (mouse)

<400>  52
gagactgaag tcggtgcaat ggtgggcagc aatgtggtgc tcagctgcat tgacccccac       60

agacgccatt tcaacttgag tggtctgtat gtctattggc aaatcgaaaa cccagaagtt      120

tcggtgactt actacctgcc ttacaagtct ccagggatca atgtggacag ttcctacaag      180

aacaggggcc atctgtccct ggactccatg aagcagggta acttctctct gtacctgaag      240

aatgtcaccc ctcaggatac ccaggagttc acatgccggg tatttatgaa tacagccaca      300

gagttagtca agatcttgga agaggtggtc aggctgcgtg tggcagcaaa cttcagtaca      360

cctgtcatca gcacctctga tagctccaac ccgggccagg aacgtaccta cacctgcatg      420

tccaagaatg gctacccaga gcccaacctg tattggatca acacaacgga caatagccta      480

atagacacgg ctctgcagaa taacactgtc tacttgaaca agttgggcct gtatgatgta      540

atcagcacat taaggctccc ttggacatct cgtggggatg ttctgtgctg cgtagagaat      600

gtggctctcc accagaacat cactagcatt agccaggcag aaagtttcac tggaaataac      660

acaaagaacc cacaggaaac ccacaataat gagcttaag                             699


<210>  53
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS-L extracellular domain amino acid sequence (mouse)

<400>  53

Glu Thr Glu Val Gly Ala Met Val Gly Ser Asn Val Val Leu Ser Cys 
1               5                   10                  15      


Ile Asp Pro His Arg Arg His Phe Asn Leu Ser Gly Leu Tyr Val Tyr 
            20                  25                  30          


Trp Gln Ile Glu Asn Pro Glu Val Ser Val Thr Tyr Tyr Leu Pro Tyr 
        35                  40                  45              


Lys Ser Pro Gly Ile Asn Val Asp Ser Ser Tyr Lys Asn Arg Gly His 
    50                  55                  60                  


Leu Ser Leu Asp Ser Met Lys Gln Gly Asn Phe Ser Leu Tyr Leu Lys 
65                  70                  75                  80  


Asn Val Thr Pro Gln Asp Thr Gln Glu Phe Thr Cys Arg Val Phe Met 
                85                  90                  95      


Asn Thr Ala Thr Glu Leu Val Lys Ile Leu Glu Glu Val Val Arg Leu 
            100                 105                 110         


Arg Val Ala Ala Asn Phe Ser Thr Pro Val Ile Ser Thr Ser Asp Ser 
        115                 120                 125             


Ser Asn Pro Gly Gln Glu Arg Thr Tyr Thr Cys Met Ser Lys Asn Gly 
    130                 135                 140                 


Tyr Pro Glu Pro Asn Leu Tyr Trp Ile Asn Thr Thr Asp Asn Ser Leu 
145                 150                 155                 160 


Ile Asp Thr Ala Leu Gln Asn Asn Thr Val Tyr Leu Asn Lys Leu Gly 
                165                 170                 175     


Leu Tyr Asp Val Ile Ser Thr Leu Arg Leu Pro Trp Thr Ser Arg Gly 
            180                 185                 190         


Asp Val Leu Cys Cys Val Glu Asn Val Ala Leu His Gln Asn Ile Thr 
        195                 200                 205             


Ser Ile Ser Gln Ala Glu Ser Phe Thr Gly Asn Asn Thr Lys Asn Pro 
    210                 215                 220                 


Gln Glu Thr His Asn Asn Glu Leu Lys 
225                 230             


<210>  54
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS-L full length amino acid sequence (mouse)

<400>  54

Met Gln Leu Lys Cys Pro Cys Phe Val Ser Leu Gly Thr Arg Gln Pro 
1               5                   10                  15      


Val Trp Lys Lys Leu His Val Ser Ser Gly Phe Phe Ser Gly Leu Gly 
            20                  25                  30          


Leu Phe Leu Leu Leu Leu Ser Ser Leu Cys Ala Ala Ser Ala Glu Thr 
        35                  40                  45              


Glu Val Gly Ala Met Val Gly Ser Asn Val Val Leu Ser Cys Ile Asp 
    50                  55                  60                  


Pro His Arg Arg His Phe Asn Leu Ser Gly Leu Tyr Val Tyr Trp Gln 
65                  70                  75                  80  


Ile Glu Asn Pro Glu Val Ser Val Thr Tyr Tyr Leu Pro Tyr Lys Ser 
                85                  90                  95      


Pro Gly Ile Asn Val Asp Ser Ser Tyr Lys Asn Arg Gly His Leu Ser 
            100                 105                 110         


Leu Asp Ser Met Lys Gln Gly Asn Phe Ser Leu Tyr Leu Lys Asn Val 
        115                 120                 125             


Thr Pro Gln Asp Thr Gln Glu Phe Thr Cys Arg Val Phe Met Asn Thr 
    130                 135                 140                 


Ala Thr Glu Leu Val Lys Ile Leu Glu Glu Val Val Arg Leu Arg Val 
145                 150                 155                 160 


Ala Ala Asn Phe Ser Thr Pro Val Ile Ser Thr Ser Asp Ser Ser Asn 
                165                 170                 175     


Pro Gly Gln Glu Arg Thr Tyr Thr Cys Met Ser Lys Asn Gly Tyr Pro 
            180                 185                 190         


Glu Pro Asn Leu Tyr Trp Ile Asn Thr Thr Asp Asn Ser Leu Ile Asp 
        195                 200                 205             


Thr Ala Leu Gln Asn Asn Thr Val Tyr Leu Asn Lys Leu Gly Leu Tyr 
    210                 215                 220                 


Asp Val Ile Ser Thr Leu Arg Leu Pro Trp Thr Ser Arg Gly Asp Val 
225                 230                 235                 240 


Leu Cys Cys Val Glu Asn Val Ala Leu His Gln Asn Ile Thr Ser Ile 
                245                 250                 255     


Ser Gln Ala Glu Ser Phe Thr Gly Asn Asn Thr Lys Asn Pro Gln Glu 
            260                 265                 270         


Thr His Asn Asn Glu Leu Lys Val Leu Val Pro Val Leu Ala Val Leu 
        275                 280                 285             


Ala Ala Ala Ala Phe Val Ser Phe Ile Ile Tyr Arg Arg Thr Arg Pro 
    290                 295                 300                 


His Arg Ser Tyr Thr Gly Pro Lys Thr Val Gln Leu Glu Leu Thr Asp 
305                 310                 315                 320 


His Ala 
        


<210>  55
<211>  2718
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS-L full length cDNA nucleotide sequence (mouse)

<400>  55
ccggaacccc aaccgctgca actctccgcg tccgaaatcc agcatcccgc agtctgcgct       60

cgcaccatgc agctaaagtg tccctgtttt gtgtccttgg gaaccaggca gcctgtttgg      120

aagaagctcc atgtttctag cgggttcttt tctggtcttg gtctgttctt gctgctgttg      180

agcagcctct gtgctgcctc tgcagagact gaagtcggtg caatggtggg cagcaatgtg      240

gtgctcagct gcattgaccc ccacagacgc catttcaact tgagtggtct gtatgtctat      300

tggcaaatcg aaaacccaga agtttcggtg acttactacc tgccttacaa gtctccaggg      360

atcaatgtgg acagttccta caagaacagg ggccatctgt ccctggactc catgaagcag      420

ggtaacttct ctctgtacct gaagaatgtc acccctcagg atacccagga gttcacatgc      480

cgggtattta tgaatacagc cacagagtta gtcaagatct tggaagaggt ggtcaggctg      540

cgtgtggcag caaacttcag tacacctgtc atcagcacct ctgatagctc caacccgggc      600

caggaacgta cctacacctg catgtccaag aatggctacc cagagcccaa cctgtattgg      660

atcaacacaa cggacaatag cctaatagac acggctctgc agaataacac tgtctacttg      720

aacaagttgg gcctgtatga tgtaatcagc acattaaggc tcccttggac atctcgtggg      780

gatgttctgt gctgcgtaga gaatgtggct ctccaccaga acatcactag cattagccag      840

gcagaaagtt tcactggaaa taacacaaag aacccacagg aaacccacaa taatgagtta      900

aaagtccttg tccccgtcct tgctgtactg gcggcagcgg cattcgtttc cttcatcata      960

tacagacgca cgcgtcccca ccgaagctat acaggaccca agactgtaca gcttgaactt     1020

acagaccacg cctgacagga ctctgcccag gatatggaca gggtttctgt gagttgccac     1080

caggtggatg tcagacacaa cttcagagtg gacccccaca ggcctggtga cagaggacaa     1140

cgagctgtct gcttatgggc tgtgatggag gccaggaatc cctggcttta cgaggcacag     1200

agacttcatc ccagaaaccc cgagggagat ctctccagtg ggcagcagca acatcatcgg     1260

aatatggagc ctccggtgag ctgtcggcac agagagcagc agcttgtgag aagatccttc     1320

cttggcacgt tactactcag gcctaggagc tttataaaag agcgtttgag ccactctgaa     1380

agccctacag agtctactgg agactttccc tgcaggacct tcagttgggg aggaagcctg     1440

actttattta ggtctcaggc tacttgggcc tcttcgagga tatgtgggat tttgtctact     1500

gcaaacctgt ttctggctga caatggttgg gctcagaggc actcagcttc acaacatcaa     1560

tgggacacgc ctcatccttg acttcctgtg gctacagaag ctttccgaaa gccttgagct     1620

ctttcagact gaacagctct gcccagtctc agcagcccat gaagatctca actccagctt     1680

cctgggtctc cgtgttgctg gccagaatag agctagctct tttgtttcaa gatggttctg     1740

caaagttggc tgcttggaaa cctagggatg tatgtacaag ctccaggctg atgcagtagg     1800

gggcacggac tccccgatgg aacacagtat ctgaccctag gtgagggcaa gctccttccc     1860

acgcagagga ctggaaattc tggaccgtca aggcctgtct gctatgtggc tggggctcag     1920

tgctgatgga tgtgtgagat ctcaggaatg aggagtgaga accctgggct caggactagg     1980

aagacctgtc catttttttt tttttttaat gcccacatgg actttttatt cttcacaccg     2040

atgtattcaa tgagtgtaga gagaactact taagtccttc ccgagtacaa agcattacct     2100

acctgcagaa tagcaactgt tgttatgggt cttgagttgg cagctacagc aaacaagcac     2160

aaggagcagt tggggtgcaa gaagatgggg tgcagcgccc ccaaggacag acatttggga     2220

attagtggtc tccctgatgc ccatagttcc ccaggaactc aggtgggtct gcggcagcac     2280

agtaggagta ttcctcctac tttaactttt cttgtcagac gtagtttagg ttcagaaaga     2340

ggtcaactca gcaagccagc tagccgcctt ggggcaccag acacactgcc ccccaccccc     2400

tgcttatgta ggcattggga acccttcaca gaccactggc tgtacagtca ccatcacctg     2460

ctgattccag caggccccca ccttcttgtg gaatcctggg agcactcccc tcttacccct     2520

cactgccccc caccccctgc acatcagcat tcattagatt tgccctgtaa cgtctgattc     2580

ctcctttatc tgggttgtag atggggcata gtgacttcta gaaacctaac aagggaataa     2640

atgtaagatg tgctttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2700

aaaaaaaaaa aaaaaaaa                                                   2718


<210>  56
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized ICOS-L.COMP encoding nucleotide sequence (human)

<400>  56
atggaaaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

gaattcgaca cccaagaaaa agaagtcaga gcaatggtag ggtccgacgt tgagctcagc      120

tgcgcatgtc ccgaagggag ccgatttgac cttaacgatg tctacgtcta ttggcagacc      180

agtgaatcaa agactgtagt tacctatcac ataccacaga atagttcatt ggagaacgta      240

gattcacgct ataggaatag agctctgatg tcaccggcgg gcatgttgcg aggggacttt      300

agcctgaggc ttttcaacgt tacgccacaa gatgagcaga agttccactg tcttgtactg      360

tcacagagtt tgggattcca agaggttctc tcagtggagg tcacgttgca cgtagctgcc      420

aatttcagtg tccctgttgt ctctgcaccc catagcccat cccaggacga gttgacattc      480

acttgtacaa gcataaatgg ctacccacgc ccgaatgtct attggattaa caagacagat      540

aatagcctct tggatcaagc tcttcagaat gatacggttt tcctcaacat gcgcgggctt      600

tacgacgtgg tatccgtttt gcgaatcgca cgaactcctt ctgtcaatat cggttgctgc      660

atcgagaatg tactcctgca gcagaatctt acggtcggtt ctcaaactgg caatgacatc      720

ggcgagcgcg ataaaataac tgagaatccg gtcagcacag gagaaaaaaa cgccgcaaca      780

tggtccgaat tcggctctgg accaggtcca tcgggtaccg atctggcccc ccagatgctg      840

agagagctgc aggaaacaaa cgccgccctg caggacgtgc gcgagctgct gagacagcaa      900

gtgaaagaga tcaccttcct gaagaacacc gtgatggaat gcgacgcctg cggcggctct      960

ccacaaccac agtctgagaa cctgtatttt caaggcggcc cacaaccaca gggcggatcc     1020

ggctctggct ctggcggccg ccaccaccat catcaccatc accactgatg a              1071


<210>  57
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS-L.COMP amino acid sequence (human)

<400>  57

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Phe Asp Thr Gln Glu Lys Glu Val Arg Ala Met 
            20                  25                  30          


Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg 
        35                  40                  45              


Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys 
    50                  55                  60                  


Thr Val Val Thr Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val 
65                  70                  75                  80  


Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu 
                85                  90                  95      


Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu 
            100                 105                 110         


Gln Lys Phe His Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu 
        115                 120                 125             


Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val 
    130                 135                 140                 


Pro Val Val Ser Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe 
145                 150                 155                 160 


Thr Cys Thr Ser Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile 
                165                 170                 175     


Asn Lys Thr Asp Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr 
            180                 185                 190         


Val Phe Leu Asn Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg 
        195                 200                 205             


Ile Ala Arg Thr Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val 
    210                 215                 220                 


Leu Leu Gln Gln Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile 
225                 230                 235                 240 


Gly Glu Arg Asp Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys 
                245                 250                 255     


Asn Ala Ala Thr Trp Ser Glu Phe Gly Ser Gly Pro Gly Pro Ser Gly 
            260                 265                 270         


Thr Asp Leu Ala Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala 
        275                 280                 285             


Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Lys Glu Ile 
    290                 295                 300                 


Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly Gly Ser 
305                 310                 315                 320 


Pro Gln Pro Gln Ser Glu Asn Leu Tyr Phe Gln Gly Gly Pro Gln Pro 
                325                 330                 335     


Gln Gly Gly Ser Gly Ser Gly Ser Gly Gly Arg His His His His His 
            340                 345                 350         


His His His 
        355 


<210>  58
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized ICOS-L.COMP nucleotide sequence (mouse)

<400>  58
atggaaaccg acaccctgct gctgtgggtg ctgctgctgt gggtgccagg cagcaccggc       60

gaattcgaaa ctgaagtagg agctatggtc gggtctaacg tcgtcctctc ctgcattgat      120

ccgcacagaa ggcatttcaa cttgtcaggt ctgtacgtgt actggcaaat tgaaaacccg      180

gaagtttcag ttacatacta cttgccatat aaatctcctg gtataaatgt agatagctct      240

tataaaaata gaggacatct cagtctggat tcaatgaaac aaggtaactt ctcactgtac      300

cttaagaatg taacgccaca agacacacag gaatttacgt gtagggtatt tatgaacact      360

gccacagaac tggtgaaaat acttgaagag gttgtgcgcc tgcgcgtggc ggcgaacttt      420

tcaacgcctg ttatttcaac tagtgacagt tctaatcctg gacaagaacg aacgtatacc      480

tgtatgtcca agaatggtta cccagagccc aacctttatt ggataaacac gaccgataac      540

agccttattg acacggcgct tcagaacaac acagtgtacc ttaacaaatt gggattgtat      600

gacgtaattt ccacgttgag acttccttgg actagtagag gagacgtttt gtgctgcgtg      660

gagaatgttg ctttgcatca aaatattacc tcaatttctc aagcggagtc tttcaccggc      720

aataatacca agaacccaca agaaacgcac aacaacgagt tgaaagaatt cggctctgga      780

ccaggtccat cgggtaccga tctggccccc cagatgctga gagagctgca ggaaacaaac      840

gccgccctgc aggacgtgcg cgagctgctg agacagcaag tgaaagagat caccttcctg      900

aagaacaccg tgatggaatg cgacgcctgc ggcggctctc cacaaccaca gtctgagaac      960

ctgtattttc aaggcggccc acaaccacag ggcggatccg gctctggctc tggcggccgc     1020

caccaccatc atcaccatca ccactgatga                                      1050


<210>  59
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Codon optimized ICOS-L.COMP amino acid sequence (mouse)

<400>  59

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Phe Glu Thr Glu Val Gly Ala Met Val Gly Ser 
            20                  25                  30          


Asn Val Val Leu Ser Cys Ile Asp Pro His Arg Arg His Phe Asn Leu 
        35                  40                  45              


Ser Gly Leu Tyr Val Tyr Trp Gln Ile Glu Asn Pro Glu Val Ser Val 
    50                  55                  60                  


Thr Tyr Tyr Leu Pro Tyr Lys Ser Pro Gly Ile Asn Val Asp Ser Ser 
65                  70                  75                  80  


Tyr Lys Asn Arg Gly His Leu Ser Leu Asp Ser Met Lys Gln Gly Asn 
                85                  90                  95      


Phe Ser Leu Tyr Leu Lys Asn Val Thr Pro Gln Asp Thr Gln Glu Phe 
            100                 105                 110         


Thr Cys Arg Val Phe Met Asn Thr Ala Thr Glu Leu Val Lys Ile Leu 
        115                 120                 125             


Glu Glu Val Val Arg Leu Arg Val Ala Ala Asn Phe Ser Thr Pro Val 
    130                 135                 140                 


Ile Ser Thr Ser Asp Ser Ser Asn Pro Gly Gln Glu Arg Thr Tyr Thr 
145                 150                 155                 160 


Cys Met Ser Lys Asn Gly Tyr Pro Glu Pro Asn Leu Tyr Trp Ile Asn 
                165                 170                 175     


Thr Thr Asp Asn Ser Leu Ile Asp Thr Ala Leu Gln Asn Asn Thr Val 
            180                 185                 190         


Tyr Leu Asn Lys Leu Gly Leu Tyr Asp Val Ile Ser Thr Leu Arg Leu 
        195                 200                 205             


Pro Trp Thr Ser Arg Gly Asp Val Leu Cys Cys Val Glu Asn Val Ala 
    210                 215                 220                 


Leu His Gln Asn Ile Thr Ser Ile Ser Gln Ala Glu Ser Phe Thr Gly 
225                 230                 235                 240 


Asn Asn Thr Lys Asn Pro Gln Glu Thr His Asn Asn Glu Leu Lys Glu 
                245                 250                 255     


Phe Gly Ser Gly Pro Gly Pro Ser Gly Thr Asp Leu Ala Pro Gln Met 
            260                 265                 270         


Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg Glu 
        275                 280                 285             


Leu Leu Arg Gln Gln Val Lys Glu Ile Thr Phe Leu Lys Asn Thr Val 
    290                 295                 300                 


Met Glu Cys Asp Ala Cys Gly Gly Ser Pro Gln Pro Gln Ser Glu Asn 
305                 310                 315                 320 


Leu Tyr Phe Gln Gly Gly Pro Gln Pro Gln Gly Gly Ser Gly Ser Gly 
                325                 330                 335     


Ser Gly Gly Arg His His His His His His His His 
            340                 345             


<210>  60
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep-tag-II VISTA.COMP amino acid sequence (mouse)

<400>  60

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val 
            20                  25                  30          


Cys Pro Glu Gly Gln Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro 
        35                  40                  45              


Val Ser Lys Gly His Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser 
    50                  55                  60                  


Ser Arg Gly Glu Val Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn 
65                  70                  75                  80  


Phe Thr Leu Gln His Leu Gln His His Gly Ser His Leu Lys Ala Asn 
                85                  90                  95      


Ala Ser His Asp Gln Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp 
            100                 105                 110         


His His Gly Asn Phe Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp 
        115                 120                 125             


Ser Gly Leu Tyr Cys Cys Leu Val Ile Glu Leu Lys Asn His His Pro 
    130                 135                 140                 


Glu Gln Arg Phe Tyr Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys 
145                 150                 155                 160 


Gly Ser Gly Ser Thr Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser 
                165                 170                 175     


Ile Thr Ala Glu Phe Gly Ser Gly Pro Gly Pro Ser Gly Thr Asp Leu 
            180                 185                 190         


Ala Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln 
        195                 200                 205             


Asp Val Arg Glu Leu Leu Arg Gln Gln Val Lys Glu Ile Thr Phe Leu 
    210                 215                 220                 


Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly Gly Ser Pro Gln Pro 
225                 230                 235                 240 


Gln Ser Glu Asn Leu Tyr Phe Gln Gly Gly Pro Gln Pro Gln Gly Gly 
                245                 250                 255     


Ser Gly Ser Gly Ser Gly Gly Leu Pro Glu Thr Gly Gly Trp Ser His 
            260                 265                 270         


Pro Gln Phe Glu Lys 
        275         


<210>  61
<211>  1572
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human ICOS-L extracellular domain mRNA sequence

<400>  61
gaguagagcc gaucucccgc gccccgaggu ugcuccucuc cgaggucucc cgcggcccaa       60

guucuccgcg ccccgagguc uccgcgcccc gaggucuccg cggcccgagg ucuccgcccg      120

caccaugcgg cugggcaguc cuggacugcu cuuccugcuc uucagcagcc uucgagcuga      180

uacucaggag aaggaaguca gagcgauggu aggcagcgac guggagcuca gcugcgcuug      240

cccugaagga agccguuuug auuuaaauga uguuuacgua uauuggcaaa ccagugaguc      300

gaaaaccgug gugaccuacc acaucccaca gaacagcucc uuggaaaacg uggacagccg      360

cuaccggaac cgagcccuga ugucaccggc cggcaugcug cggggcgacu ucucccugcg      420

cuuguucaac gucacccccc aggacgagca gaaguuucac ugccuggugu ugagccaauc      480

ccugggauuc caggagguuu ugagcguuga gguuacacug cauguggcag caaacuucag      540

cgugcccguc gucagcgccc cccacagccc cucccaggau gagcucaccu ucacguguac      600

auccauaaac ggcuacccca ggcccaacgu guacuggauc aauaagacgg acaacagccu      660

gcuggaccag gcucugcaga augacaccgu cuucuugaac augcggggcu uguaugacgu      720

ggucagcgug cugaggaucg cacggacccc cagcgugaac auuggcugcu gcauagagaa      780

cgugcuucug cagcagaacc ugacugucgg cagccagaca ggaaaugaca ucggagagag      840

agacaagauc acagagaauc cagucaguac cggcgagaaa aacgcggcca cguggagcau      900

ccuggcuguc cugugccugc uuguggucgu ggcgguggcc auaggcuggg ugugcaggga      960

ccgaugccuc caacacagcu augcaggugc cugggcugug aguccggaga cagagcucac     1020

uggccacguu ugaccggagc ucaccgccca gagcguggac agggcuucca ugagacgcca     1080

ccgugagagg ccagguggca gcuugagcau ggacucccag acugcagggg agcacuuggg     1140

gcagccccca gaaggaccac ugcuggaucc cagggagaac cugcuggcgu uggcugugau     1200

ccuggaauga ggcccuuuca aaagcgucau ccacaccaaa ggcaaauguc cccaagugag     1260

ugggcucccc gcugucacug ccagucaccc acaggaaggg acuggugaug ggcugucucu     1320

acccggagcg ugcgggauuc agcaccaggc ucuucccagu accccagacc cacugugggu     1380

cuucccgugg gaugcgggau ccugagaccg aaggguguuu gguuuaaaaa gaagacuggg     1440

cguccgcucu uccaggacgg ccucugugcu gcugggguca cgcgaggcug uuugcagggg     1500

acacggucac aggagcucuu cugcccugaa cgcuuccaac cugcuccggc cggaagccac     1560

aggacccacu ca                                                         1572


<210>  62
<211>  657
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human PD-L1 extracellular domain mRNA sequence

<400>  62
uuuacuauca cggcuccaaa ggacuuguac gugguggagu auggcagcaa cgucacgaug       60

gagugcagau ucccuguaga acgggagcug gaccugcuug cguuaguggu guacugggaa      120

aaggaagaug agcaagugau ucaguuugug gcaggagagg aggaccuuaa gccucagcac      180

agcaacuuca gggggagagc cucgcugcca aaggaccagc uuuugaaggg aaaugcugcc      240

cuucagauca cagacgucaa gcugcaggac gcaggcguuu acugcugcau aaucagcuac      300

gguggugcgg acuacaagcg aaucacgcug aaagucaaug ccccauaccg caaaaucaac      360

cagagaauuu ccguggaucc agccacuucu gagcaugaac uaauauguca ggccgagggu      420

uauccagaag cugagguaau cuggacaaac agugaccacc aacccgugag ugggaagaga      480

agugucacca cuucccggac agaggggaug cuucucaaug ugaccagcag ucugaggguc      540

aacgccacag cgaaugaugu uuucuacugu acguuuugga gaucacagcc agggcaaaac      600

cacacagcgg agcugaucau cccagaacug ccugcaacac auccuccaca gaacagg         657


