                         SEQUENCE LISTING

<110>  The Broad Institute
       Massachusetts Institute of Technology
       Brigham and Women's Hospital
       Wallrapp, Antonia
       Riesenfeld, Samantha J.
       Burkett, Patrick R.
       Kowalczyk, Monika S.
       Regev, Aviv
       Kurchroo, Vijay K.
 
<120>  Methods and Compositions for Regulating Innate Lymphoid Cell 
       Inflammatory Responses

<130>  BROD-2007WP

<150>  US 62/476,352
<151>  2017-03-24

<150>  US 62/558,298
<151>  2017-09-13

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Pro Leu Cys Leu Asn Cys Ser Val Leu Pro Gly Asp Leu Tyr 
1               5                   10                  15      


Pro Gly Gly Ala Arg Asn Pro Met Ala Cys Asn Gly Ser Ala Ala Arg 
            20                  25                  30          


Gly His Phe Asp Pro Glu Asp Leu Asn Leu Thr Asp Glu Ala Leu Arg 
        35                  40                  45              


Leu Lys Tyr Leu Gly Pro Gln Gln Thr Glu Leu Phe Met Pro Ile Cys 
    50                  55                  60                  


Ala Thr Tyr Leu Leu Ile Phe Val Val Gly Ala Val Gly Asn Gly Leu 
65                  70                  75                  80  


Thr Cys Leu Val Ile Leu Arg His Lys Ala Met Arg Thr Pro Thr Asn 
                85                  90                  95      


Tyr Tyr Leu Phe Ser Leu Ala Val Ser Asp Leu Leu Val Leu Leu Val 
            100                 105                 110         


Gly Leu Pro Leu Glu Leu Tyr Glu Met Trp His Asn Tyr Pro Phe Leu 
        115                 120                 125             


Leu Gly Val Gly Gly Cys Tyr Phe Arg Thr Leu Leu Phe Glu Met Val 
    130                 135                 140                 


Cys Leu Ala Ser Val Leu Asn Val Thr Ala Leu Ser Val Glu Arg Tyr 
145                 150                 155                 160 


Val Ala Val Val His Pro Leu Gln Ala Arg Ser Met Val Thr Arg Ala 
                165                 170                 175     


His Val Arg Arg Val Leu Gly Ala Val Trp Gly Leu Ala Met Leu Cys 
            180                 185                 190         


Ser Leu Pro Asn Thr Ser Leu His Gly Ile Arg Gln Leu His Val Pro 
        195                 200                 205             


Cys Arg Gly Pro Val Pro Asp Ser Ala Val Cys Met Leu Val Arg Pro 
    210                 215                 220                 


Arg Ala Leu Tyr Asn Met Val Val Gln Thr Thr Ala Leu Leu Phe Phe 
225                 230                 235                 240 


Cys Leu Pro Met Ala Ile Met Ser Val Leu Tyr Leu Leu Ile Gly Leu 
                245                 250                 255     


Arg Leu Arg Arg Glu Arg Leu Leu Leu Met Gln Glu Ala Lys Gly Arg 
            260                 265                 270         


Gly Ser Ala Ala Ala Arg Ser Arg Tyr Thr Cys Arg Leu Gln Gln His 
        275                 280                 285             


Asp Arg Gly Arg Arg Gln Val Thr Lys Met Leu Phe Val Leu Val Val 
    290                 295                 300                 


Val Phe Gly Ile Cys Trp Ala Pro Phe His Ala Asp Arg Val Met Trp 
305                 310                 315                 320 


Ser Val Val Ser Gln Trp Thr Asp Gly Leu His Leu Ala Phe Gln His 
                325                 330                 335     


Val His Val Ile Ser Gly Ile Phe Phe Tyr Leu Gly Ser Ala Ala Asn 
            340                 345                 350         


Pro Val Leu Tyr Ser Leu Met Ser Ser Arg Phe Arg Glu Thr Phe Gln 
        355                 360                 365             


Glu Ala Leu Cys Leu Gly Ala Cys Cys His Arg Leu Arg Pro Arg His 
    370                 375                 380                 


Ser Ser His Ser Leu Ser Arg Met Thr Thr Gly Ser Thr Leu Cys Asp 
385                 390                 395                 400 


Val Gly Ser Leu Gly Ser Trp Val His Pro Leu Ala Gly Asn Asp Gly 
                405                 410                 415     


Pro Glu Ala Gln Gln Glu Thr Asp Pro Ser 
            420                 425     


<210>  2
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Arg Thr Glu Ser Cys Arg Pro Arg Ser Pro Ala Gly Gln Val 
1               5                   10                  15      


Ala Ala Ala Ser Pro Leu Leu Leu Leu Leu Leu Leu Leu Ala Trp Cys 
            20                  25                  30          


Ala Gly Ala Cys Arg Gly Ala Pro Ile Leu Pro Gln Gly Leu Gln Pro 
        35                  40                  45              


Glu Gln Gln Leu Gln Leu Trp Asn Glu Ile Asp Asp Thr Cys Ser Ser 
    50                  55                  60                  


Phe Leu Ser Ile Asp Ser Gln Pro Gln Ala Ser Asn Ala Leu Glu Glu 
65                  70                  75                  80  


Leu Cys Phe Met Ile Met Gly Met Leu Pro Lys Pro Gln Glu Gln Asp 
                85                  90                  95      


Glu Lys Asp Asn Thr Lys Arg Phe Leu Phe His Tyr Ser Lys Thr Gln 
            100                 105                 110         


Lys Leu Gly Lys Ser Asn Val Val Ser Ser Val Val His Pro Leu Leu 
        115                 120                 125             


Gln Leu Val Pro His Leu His Glu Arg Arg Met Lys Arg Phe Arg Val 
    130                 135                 140                 


Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg Gly Tyr Phe 
145                 150                 155                 160 


Leu Phe Arg Pro Arg Asn Gly Arg Arg Ser Ala Gly Phe Ile 
                165                 170                 


<210>  3
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Glu Arg Pro Arg Leu Gly Glu Asp Ser Ser Leu Ile Ser Leu 
1               5                   10                  15      


Phe Leu Gln Val Val Ala Phe Leu Ala Met Val Met Gly Thr His Thr 
            20                  25                  30          


Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
        35                  40                  45              


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
    50                  55                  60                  


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
65                  70                  75                  80  


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
                85                  90                  95      


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
            100                 105                 110         


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
        115                 120                 125             


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
    130                 135                 140                 


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
                165                 170                 175     


Gly 
    


<210>  4
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25  


<210>  5
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  (PEG)2   40 kDa

<400>  5

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25  


<210>  6
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  6

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25  


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   


<210>  8
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  8

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Pro Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  9

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Pro Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25  


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  10

Cys Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl)

<400>  11

Cys Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2  40 kDa

<400>  12

Cys Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(Cholesteroyl)

<400>  13

Cys Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   10  


<210>  14
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  14

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  15
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl)

<400>  15

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  16
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2  40 kDa

<400>  16

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  17
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2 40 kDa

<400>  17

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  18
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(Cholesteroyl)

<400>  18

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  19
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG) 20 kDa

<400>  19

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  20
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2 20 kDa

<400>  20

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  21
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  D-Alanine

<400>  21

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Ala Trp Arg Pro Arg Asn 
            20                  25      


<210>  22
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl)

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  D-Alanine

<400>  22

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Ala Trp Arg Pro Arg Asn 
            20                  25      


<210>  23
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2 40 kDa

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  D-Alanine

<400>  23

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Ala Trp Arg Pro Arg Asn 
            20                  25      


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X at position 2 = 1-amino-4,7,10-trioxa-13-tridecanamine 
       succinimic acid

<400>  24

Cys Xaa Phe Leu Phe Arg Pro Arg Asn 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X at position 2 = 1-amino-4,7,10-trioxa-13-tridecanamine 
       succinimic acid

<400>  25

Cys Xaa Phe Leu Phe Arg Pro Arg Asn 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2 40 kDa

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N at position 2 = 1-amino-4,7,10-trioxa-13-tridecanamine 
       succinimic acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X at position 2 = 1-amino-4,7,10-trioxa-13-tridecanamine 
       succinimic acid

<400>  26

Cys Xaa Phe Leu Phe Arg Pro Arg Asn 
1               5                   


<210>  27
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  27

Cys Ala Ser Gln Ser Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl

<400>  28

Cys Ala Ser Gln Ser Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2 40 kDa

<400>  29

Cys Ala Ser Gln Ser Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   10                  15  


<210>  30
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  30

Cys Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg Gly Tyr Phe Leu Phe 
1               5                   10                  15      


Arg Pro Arg Asn 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl)

<400>  31

Cys Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg Gly Tyr Phe Leu Phe 
1               5                   10                  15      


Arg Pro Arg Asn 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2 40 kDa

<400>  32

Cys Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg Gly Tyr Phe Leu Phe 
1               5                   10                  15      


Arg Pro Arg Asn 
            20  


<210>  33
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  33

Cys Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln 
1               5                   10                  15      


Ser Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25          


<210>  34
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl)

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Cys(N-ethylmaleimidyl)

<400>  34

Cys Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln 
1               5                   10                  15      


Ser Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25          


<210>  35
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG) 20 kDa

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Cys(PEG)20 kDa

<400>  35

Cys Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln 
1               5                   10                  15      


Ser Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25          


<210>  36
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Palmitoyl-Cysteine

<400>  36

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  37
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Palmitoyl Cysteine

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl)

<400>  37

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  38
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Palmitoyl Cysteine

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2 40 kDa

<400>  38

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  39
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG) 40 kDa

<400>  39

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  40
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X at position 2 = 1-amino-4,7,10-trioxa-13-tridecanamine 
       succinimic acid

<400>  40

Cys Xaa Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X at position 2 = 1-amino-4,7,10-trioxa-13-tridecanamine 
       succinimic acid

<400>  41

Cys Xaa Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2 40 kDa

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X at position 2 = 1-amino-4,7,10-trioxa-13-tridecanamine 
       succinimic acid

<400>  42

Cys Xaa Gly Tyr Phe Leu Phe Arg Pro Arg Asn 
1               5                   10      


<210>  43
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl)

<400>  43

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Pro Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  44
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2 40 kDa

<400>  44

Cys Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser 
1               5                   10                  15      


Arg Pro Tyr Phe Leu Phe Arg Pro Arg Asn 
            20                  25      


<210>  45
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  45

Tyr Phe Trp Arg Pro Arg Asn 
1               5           


<210>  46
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L at position 3 is D-Leucine

<400>  46

Tyr Phe Leu Trp Arg Pro Arg Asn 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  47

Tyr Phe Gly Trp Arg Pro Arg Asn 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  A at position 3 is D-Alanine

<400>  48

Tyr Phe Ala Trp Arg Pro Arg Asn 
1               5               


<210>  49
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L at position 2 is D-Leucine

<400>  49

Phe Leu Trp Arg Pro Arg Asn 
1               5           


<210>  50
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  50

Phe Phe Arg Pro Arg Asn 
1               5       


<210>  51
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  51

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Gly Tyr Phe Trp Arg Pro Arg Asn 
            20                  


<210>  52
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  L at position 20 is D-Leucine

<400>  52

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Gly Tyr Phe Leu Trp Arg Pro Arg Asn 
            20                  25  


<210>  53
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X at position 7 is Homoarginine

<400>  53

Phe Trp Leu Phe Arg Pro Xaa Asn 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X at position 7 is Homoarginine

<400>  54

Phe Trp Leu Phe Arg Ala Xaa Asn 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X at position 8 is Norleucine

<400>  55

Trp Phe Leu Phe Arg Ala Arg Xaa 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  56

Phe Trp Leu Phe Arg Ala Arg Asn 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  57

Trp Ala Leu Phe Arg Ala Arg Asn 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  58

Phe Ala Leu Phe Arg Pro Arg Asn 
1               5               


<210>  59
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X at position 24 is Homoarginine

<400>  59

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Gly Phe Trp Leu Phe Arg Pro Xaa Asn 
            20                  25  


<210>  60
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X at position 24 is Homoarginine

<400>  60

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Gly Phe Trp Leu Phe Arg Ala Xaa Asn 
            20                  25  


<210>  61
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X at position 25 is Norleucine

<400>  61

Phe Arg Val Asp Glu Glu Phe Gln Ser Pro Phe Ala Ser Gln Ser Arg 
1               5                   10                  15      


Gly Phe Trp Leu Phe Arg Pro Arg Xaa 
            20                  25  


<210>  62
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  62

Ile Leu Gln Arg Gly Ser Gly Thr Ala Ala Val Asp Phe Thr Lys Lys 
1               5                   10                  15      


Asp His Thr Ala Thr Trp Gly Arg Pro Phe Phe Leu Phe Arg Pro Arg 
            20                  25                  30          


Asn 
    


<210>  63
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  63

Cys Ile Leu Gln Arg Gly Ser Gly Thr Ala Ala Val Asp Phe Thr Lys 
1               5                   10                  15      


Lys Asp His Thr Ala Thr Trp Gly Arg Pro Phe Phe Leu Phe Arg Pro 
            20                  25                  30          


Arg Asn 
        


<210>  64
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(N-ethylmaleimidyl)

<400>  64

Cys Ile Leu Gln Arg Gly Ser Gly Thr Ala Ala Val Asp Phe Thr Lys 
1               5                   10                  15      


Lys Asp His Thr Ala Thr Trp Gly Arg Pro Phe Phe Leu Phe Arg Pro 
            20                  25                  30          


Arg Asn 
        


<210>  65
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)2 40 kDa

<400>  65

Cys Ile Leu Gln Arg Gly Ser Gly Thr Ala Ala Val Asp Phe Thr Lys 
1               5                   10                  15      


Lys Asp His Thr Ala Thr Trp Gly Arg Pro Phe Phe Leu Phe Arg Pro 
            20                  25                  30          


Arg Asn 
        


<210>  66
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(Cholesteroyl)

<400>  66

Cys Ile Leu Gln Arg Gly Ser Gly Thr Ala Ala Val Asp Phe Thr Lys 
1               5                   10                  15      


Lys Asp His Thr Ala Thr Trp Gly Arg Pro Phe Phe Leu Phe Arg Pro 
            20                  25                  30          


Arg Asn 
        


<210>  67
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Cys(PEG)20 kDa

<400>  67

Cys Ile Leu Gln Arg Gly Ser Gly Thr Ala Ala Val Asp Phe Thr Lys 
1               5                   10                  15      


Lys Asp His Thr Ala Thr Trp Gly Arg Pro Phe Phe Leu Phe Arg Pro 
            20                  25                  30          


Arg Asn 
        


<210>  68
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Palmitoyl Isoleucine

<400>  68

Ile Leu Gln Arg Gly Ser Gly Thr Ala Ala Val Asp Phe Thr Lys Lys 
1               5                   10                  15      


Asp His Thr Ala Thr Trp Gly Arg Pro Phe Phe Leu Phe Arg Pro Arg 
            20                  25                  30          


Asn 
    


<210>  69
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Met Asp Pro Ile Arg Ser Arg Thr Pro Ser Pro Ala Arg Glu Leu Leu 
1               5                   10                  15      


Ser Gly Pro Gln Pro Asp Gly Val Gln Pro Thr Ala Asp Arg Gly Val 
            20                  25                  30          


Ser Pro Pro Ala Gly Gly Pro Leu Asp Gly Leu Pro Ala Arg Arg Thr 
        35                  40                  45              


Met Ser Arg Thr Arg Leu Pro Ser Pro Pro Ala Pro Ser Pro Ala Phe 
    50                  55                  60                  


Ser Ala Asp Ser Phe Ser Asp Leu Leu Arg Gln Phe Asp Pro Ser Leu 
65                  70                  75                  80  


Phe Asn Thr Ser Leu Phe Asp Ser Leu Pro Pro Phe Gly Ala His His 
                85                  90                  95      


Thr Glu Ala Ala Thr Gly Glu Trp Asp Glu Val Gln Ser Gly Leu Arg 
            100                 105                 110         


Ala Ala Asp Ala Pro Pro Pro Thr Met Arg Val Ala Val Thr Ala Ala 
        115                 120                 125             


Arg Pro Pro Arg Ala Lys Pro Ala Pro Arg Arg Arg Ala Ala Gln Pro 
    130                 135                 140                 


Ser Asp Ala Ser Pro Ala Ala Gln Val Asp Leu Arg Thr Leu Gly Tyr 
145                 150                 155                 160 


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 
                165                 170                 175     


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
            180                 185                 190         


Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 
        195                 200                 205             


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 
    210                 215                 220                 


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
225                 230                 235                 240 


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
                245                 250                 255     


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
            260                 265                 270         


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
        275                 280                 285             


<210>  70
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro 
1               5                   10                  15      


Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu 
            20                  25                  30          


Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala 
        35                  40                  45              


Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr Ser 
    50                  55                  60                  


His Arg Val Ala Asp His Ala Gln Val Val Arg Val Leu Gly Phe Phe 
65                  70                  75                  80  


Gln Cys His Ser His Pro Ala Gln Ala Phe Asp Asp Ala Met Thr Gln 
                85                  90                  95      


Phe Gly Met Ser Arg His Gly Leu Leu Gln Leu Phe Arg Arg Val Gly 
            100                 105                 110         


Val Thr Glu Leu Glu Ala Arg Ser Gly Thr Leu Pro Pro Ala Ser Gln 
        115                 120                 125             


Arg Trp Asp Arg Ile Leu Gln Ala Ser Gly Met Lys Arg Ala Lys Pro 
    130                 135                 140                 


Ser Pro Thr Ser Thr Gln Thr Pro Asp Gln Ala Ser Leu His Ala Phe 
145                 150                 155                 160 


Ala Asp Ser Leu Glu Arg Asp Leu Asp Ala Pro Ser Pro Met His Glu 
                165                 170                 175     


Gly Asp Gln Thr Arg Ala Ser 
            180             


