                         SEQUENCE LISTING

<110>  CHILDREN'S MEDICAL CENTER CORPORATION
 
<120>  PRSS2 INHIBITION

<130>  C1233.70117WO00

<140>  PCT/US2018/023830
<141>  2018-03-22

<150>  US 62/475,143
<151>  2017-03-22

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  4524
<212>  PRT
<213>  Homo sapiens

<400>  1

Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe Ala Cys Arg Asp 
1               5                   10                  15      


Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp Gly Glu Arg Asp 
            20                  25                  30          


Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys Pro Gln Ser Lys 
        35                  40                  45              


Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu Gly Thr Glu Leu 
    50                  55                  60                  


Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln Asp Cys Met Asp 
65                  70                  75                  80  


Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln Gly Asn Cys Ser 
                85                  90                  95      


Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu Asp Gly Pro Thr 
            100                 105                 110         


Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp Gly Lys Thr Cys 
        115                 120                 125             


Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys Ser Gln Leu Cys 
    130                 135                 140                 


Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val Glu Gly Tyr Leu 
145                 150                 155                 160 


Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn Glu Pro Val Asp 
                165                 170                 175     


Arg Pro Pro Val Leu Leu Ile Ala Asn Ser Gln Asn Ile Leu Ala Thr 
            180                 185                 190         


Tyr Leu Ser Gly Ala Gln Val Ser Thr Ile Thr Pro Thr Ser Thr Arg 
        195                 200                 205             


Gln Thr Thr Ala Met Asp Phe Ser Tyr Ala Asn Glu Thr Val Cys Trp 
    210                 215                 220                 


Val His Val Gly Asp Ser Ala Ala Gln Thr Gln Leu Lys Cys Ala Arg 
225                 230                 235                 240 


Met Pro Gly Leu Lys Gly Phe Val Asp Glu His Thr Ile Asn Ile Ser 
                245                 250                 255     


Leu Ser Leu His His Val Glu Gln Met Ala Ile Asp Trp Leu Thr Gly 
            260                 265                 270         


Asn Phe Tyr Phe Val Asp Asp Ile Asp Asp Arg Ile Phe Val Cys Asn 
        275                 280                 285             


Arg Asn Gly Asp Thr Cys Val Thr Leu Leu Asp Leu Glu Leu Tyr Asn 
    290                 295                 300                 


Pro Lys Gly Ile Ala Leu Asp Pro Ala Met Gly Lys Val Phe Phe Thr 
305                 310                 315                 320 


Asp Tyr Gly Gln Ile Pro Lys Val Glu Arg Cys Asp Met Asp Gly Gln 
                325                 330                 335     


Asn Arg Thr Lys Leu Val Asp Ser Lys Ile Val Phe Pro His Gly Ile 
            340                 345                 350         


Thr Leu Asp Leu Val Ser Arg Leu Val Tyr Trp Ala Asp Ala Tyr Leu 
        355                 360                 365             


Asp Tyr Ile Glu Val Val Asp Tyr Glu Gly Lys Gly Arg Gln Thr Ile 
    370                 375                 380                 


Ile Gln Gly Ile Leu Ile Glu His Leu Tyr Gly Leu Thr Val Phe Glu 
385                 390                 395                 400 


Asn Tyr Leu Tyr Ala Thr Asn Ser Asp Asn Ala Asn Ala Gln Gln Lys 
                405                 410                 415     


Thr Ser Val Ile Arg Val Asn Arg Phe Asn Ser Thr Glu Tyr Gln Val 
            420                 425                 430         


Val Thr Arg Val Asp Lys Gly Gly Ala Leu His Ile Tyr His Gln Arg 
        435                 440                 445             


Arg Gln Pro Arg Val Arg Ser His Ala Cys Glu Asn Asp Gln Tyr Gly 
    450                 455                 460                 


Lys Pro Gly Gly Cys Ser Asp Ile Cys Leu Leu Ala Asn Ser His Lys 
465                 470                 475                 480 


Ala Arg Thr Cys Arg Cys Arg Ser Gly Phe Ser Leu Gly Ser Asp Gly 
                485                 490                 495     


Lys Ser Cys Lys Lys Pro Glu His Glu Leu Phe Leu Val Tyr Gly Lys 
            500                 505                 510         


Gly Arg Pro Gly Ile Ile Arg Gly Met Asp Met Gly Ala Lys Val Pro 
        515                 520                 525             


Asp Glu His Met Ile Pro Ile Glu Asn Leu Met Asn Pro Arg Ala Leu 
    530                 535                 540                 


Asp Phe His Ala Glu Thr Gly Phe Ile Tyr Phe Ala Asp Thr Thr Ser 
545                 550                 555                 560 


Tyr Leu Ile Gly Arg Gln Lys Ile Asp Gly Thr Glu Arg Glu Thr Ile 
                565                 570                 575     


Leu Lys Asp Gly Ile His Asn Val Glu Gly Val Ala Val Asp Trp Met 
            580                 585                 590         


Gly Asp Asn Leu Tyr Trp Thr Asp Asp Gly Pro Lys Lys Thr Ile Ser 
        595                 600                 605             


Val Ala Arg Leu Glu Lys Ala Ala Gln Thr Arg Lys Thr Leu Ile Glu 
    610                 615                 620                 


Gly Lys Met Thr His Pro Arg Ala Ile Val Val Asp Pro Leu Asn Gly 
625                 630                 635                 640 


Trp Met Tyr Trp Thr Asp Trp Glu Glu Asp Pro Lys Asp Ser Arg Arg 
                645                 650                 655     


Gly Arg Leu Glu Arg Ala Trp Met Asp Gly Ser His Arg Asp Ile Phe 
            660                 665                 670         


Val Thr Ser Lys Thr Val Leu Trp Pro Asn Gly Leu Ser Leu Asp Ile 
        675                 680                 685             


Pro Ala Gly Arg Leu Tyr Trp Val Asp Ala Phe Tyr Asp Arg Ile Glu 
    690                 695                 700                 


Thr Ile Leu Leu Asn Gly Thr Asp Arg Lys Ile Val Tyr Glu Gly Pro 
705                 710                 715                 720 


Glu Leu Asn His Ala Phe Gly Leu Cys His His Gly Asn Tyr Leu Phe 
                725                 730                 735     


Trp Thr Glu Tyr Arg Ser Gly Ser Val Tyr Arg Leu Glu Arg Gly Val 
            740                 745                 750         


Gly Gly Ala Pro Pro Thr Val Thr Leu Leu Arg Ser Glu Arg Pro Pro 
        755                 760                 765             


Ile Phe Glu Ile Arg Met Tyr Asp Ala Gln Gln Gln Gln Val Gly Thr 
    770                 775                 780                 


Asn Lys Cys Arg Val Asn Asn Gly Gly Cys Ser Ser Leu Cys Leu Ala 
785                 790                 795                 800 


Thr Pro Gly Ser Arg Gln Cys Ala Cys Ala Glu Asp Gln Val Leu Asp 
                805                 810                 815     


Ala Asp Gly Val Thr Cys Leu Ala Asn Pro Ser Tyr Val Pro Pro Pro 
            820                 825                 830         


Gln Cys Gln Pro Gly Glu Phe Ala Cys Ala Asn Ser Arg Cys Ile Gln 
        835                 840                 845             


Glu Arg Trp Lys Cys Asp Gly Asp Asn Asp Cys Leu Asp Asn Ser Asp 
    850                 855                 860                 


Glu Ala Pro Ala Leu Cys His Gln His Thr Cys Pro Ser Asp Arg Phe 
865                 870                 875                 880 


Lys Cys Glu Asn Asn Arg Cys Ile Pro Asn Arg Trp Leu Cys Asp Gly 
                885                 890                 895     


Asp Asn Asp Cys Gly Asn Ser Glu Asp Glu Ser Asn Ala Thr Cys Ser 
            900                 905                 910         


Ala Arg Thr Cys Pro Pro Asn Gln Phe Ser Cys Ala Ser Gly Arg Cys 
        915                 920                 925             


Ile Pro Ile Ser Trp Thr Cys Asp Leu Asp Asp Asp Cys Gly Asp Arg 
    930                 935                 940                 


Ser Asp Glu Ser Ala Ser Cys Ala Tyr Pro Thr Cys Phe Pro Leu Thr 
945                 950                 955                 960 


Gln Phe Thr Cys Asn Asn Gly Arg Cys Ile Asn Ile Asn Trp Arg Cys 
                965                 970                 975     


Asp Asn Asp Asn Asp Cys Gly Asp Asn Ser Asp Glu Ala Gly Cys Ser 
            980                 985                 990         


His Ser Cys Ser Ser Thr Gln Phe  Lys Cys Asn Ser Gly  Arg Cys Ile 
        995                 1000                 1005             


Pro Glu  His Trp Thr Cys Asp  Gly Asp Asn Asp Cys  Gly Asp Tyr 
    1010                 1015                 1020             


Ser Asp  Glu Thr His Ala Asn  Cys Thr Asn Gln Ala  Thr Arg Pro 
    1025                 1030                 1035             


Pro Gly  Gly Cys His Thr Asp  Glu Phe Gln Cys Arg  Leu Asp Gly 
    1040                 1045                 1050             


Leu Cys  Ile Pro Leu Arg Trp  Arg Cys Asp Gly Asp  Thr Asp Cys 
    1055                 1060                 1065             


Met Asp  Ser Ser Asp Glu Lys  Ser Cys Glu Gly Val  Thr His Val 
    1070                 1075                 1080             


Cys Asp  Pro Ser Val Lys Phe  Gly Cys Lys Asp Ser  Ala Arg Cys 
    1085                 1090                 1095             


Ile Ser  Lys Ala Trp Val Cys  Asp Gly Asp Asn Asp  Cys Glu Asp 
    1100                 1105                 1110             


Asn Ser  Asp Glu Glu Asn Cys  Glu Ser Leu Ala Cys  Arg Pro Pro 
    1115                 1120                 1125             


Ser His  Pro Cys Ala Asn Asn  Thr Ser Val Cys Leu  Pro Pro Asp 
    1130                 1135                 1140             


Lys Leu  Cys Asp Gly Asn Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    1145                 1150                 1155             


Gly Glu  Leu Cys Asp Gln Cys  Ser Leu Asn Asn Gly  Gly Cys Ser 
    1160                 1165                 1170             


His Asn  Cys Ser Val Ala Pro  Gly Glu Gly Ile Val  Cys Ser Cys 
    1175                 1180                 1185             


Pro Leu  Gly Met Glu Leu Gly  Pro Asp Asn His Thr  Cys Gln Ile 
    1190                 1195                 1200             


Gln Ser  Tyr Cys Ala Lys His  Leu Lys Cys Ser Gln  Lys Cys Asp 
    1205                 1210                 1215             


Gln Asn  Lys Phe Ser Val Lys  Cys Ser Cys Tyr Glu  Gly Trp Val 
    1220                 1225                 1230             


Leu Glu  Pro Asp Gly Glu Ser  Cys Arg Ser Leu Asp  Pro Phe Lys 
    1235                 1240                 1245             


Pro Phe  Ile Ile Phe Ser Asn  Arg His Glu Ile Arg  Arg Ile Asp 
    1250                 1255                 1260             


Leu His  Lys Gly Asp Tyr Ser  Val Leu Val Pro Gly  Leu Arg Asn 
    1265                 1270                 1275             


Thr Ile  Ala Leu Asp Phe His  Leu Ser Gln Ser Ala  Leu Tyr Trp 
    1280                 1285                 1290             


Thr Asp  Val Val Glu Asp Lys  Ile Tyr Arg Gly Lys  Leu Leu Asp 
    1295                 1300                 1305             


Asn Gly  Ala Leu Thr Ser Phe  Glu Val Val Ile Gln  Tyr Gly Leu 
    1310                 1315                 1320             


Ala Thr  Pro Glu Gly Leu Ala  Val Asp Trp Ile Ala  Gly Asn Ile 
    1325                 1330                 1335             


Tyr Trp  Val Glu Ser Asn Leu  Asp Gln Ile Glu Val  Ala Lys Leu 
    1340                 1345                 1350             


Asp Gly  Thr Leu Arg Thr Thr  Leu Leu Ala Gly Asp  Ile Glu His 
    1355                 1360                 1365             


Pro Arg  Ala Ile Ala Leu Asp  Pro Arg Asp Gly Ile  Leu Phe Trp 
    1370                 1375                 1380             


Thr Asp  Trp Asp Ala Ser Leu  Pro Arg Ile Glu Ala  Ala Ser Met 
    1385                 1390                 1395             


Ser Gly  Ala Gly Arg Arg Thr  Val His Arg Glu Thr  Gly Ser Gly 
    1400                 1405                 1410             


Gly Trp  Pro Asn Gly Leu Thr  Val Asp Tyr Leu Glu  Lys Arg Ile 
    1415                 1420                 1425             


Leu Trp  Ile Asp Ala Arg Ser  Asp Ala Ile Tyr Ser  Ala Arg Tyr 
    1430                 1435                 1440             


Asp Gly  Ser Gly His Met Glu  Val Leu Arg Gly His  Glu Phe Leu 
    1445                 1450                 1455             


Ser His  Pro Phe Ala Val Thr  Leu Tyr Gly Gly Glu  Val Tyr Trp 
    1460                 1465                 1470             


Thr Asp  Trp Arg Thr Asn Thr  Leu Ala Lys Ala Asn  Lys Trp Thr 
    1475                 1480                 1485             


Gly His  Asn Val Thr Val Val  Gln Arg Thr Asn Thr  Gln Pro Phe 
    1490                 1495                 1500             


Asp Leu  Gln Val Tyr His Pro  Ser Arg Gln Pro Met  Ala Pro Asn 
    1505                 1510                 1515             


Pro Cys  Glu Ala Asn Gly Gly  Gln Gly Pro Cys Ser  His Leu Cys 
    1520                 1525                 1530             


Leu Ile  Asn Tyr Asn Arg Thr  Val Ser Cys Ala Cys  Pro His Leu 
    1535                 1540                 1545             


Met Lys  Leu His Lys Asp Asn  Thr Thr Cys Tyr Glu  Phe Lys Lys 
    1550                 1555                 1560             


Phe Leu  Leu Tyr Ala Arg Gln  Met Glu Ile Arg Gly  Val Asp Leu 
    1565                 1570                 1575             


Asp Ala  Pro Tyr Tyr Asn Tyr  Ile Ile Ser Phe Thr  Val Pro Asp 
    1580                 1585                 1590             


Ile Asp  Asn Val Thr Val Leu  Asp Tyr Asp Ala Arg  Glu Gln Arg 
    1595                 1600                 1605             


Val Tyr  Trp Ser Asp Val Arg  Thr Gln Ala Ile Lys  Arg Ala Phe 
    1610                 1615                 1620             


Ile Asn  Gly Thr Gly Val Glu  Thr Val Val Ser Ala  Asp Leu Pro 
    1625                 1630                 1635             


Asn Ala  His Gly Leu Ala Val  Asp Trp Val Ser Arg  Asn Leu Phe 
    1640                 1645                 1650             


Trp Thr  Ser Tyr Asp Thr Asn  Lys Lys Gln Ile Asn  Val Ala Arg 
    1655                 1660                 1665             


Leu Asp  Gly Ser Phe Lys Asn  Ala Val Val Gln Gly  Leu Glu Gln 
    1670                 1675                 1680             


Pro His  Gly Leu Val Val His  Pro Leu Arg Gly Lys  Leu Tyr Trp 
    1685                 1690                 1695             


Thr Asp  Gly Asp Asn Ile Ser  Met Ala Asn Met Asp  Gly Ser Asn 
    1700                 1705                 1710             


Arg Thr  Leu Leu Phe Ser Gly  Gln Lys Gly Pro Val  Gly Leu Ala 
    1715                 1720                 1725             


Ile Asp  Phe Pro Glu Ser Lys  Leu Tyr Trp Ile Ser  Ser Gly Asn 
    1730                 1735                 1740             


His Thr  Ile Asn Arg Cys Asn  Leu Asp Gly Ser Gly  Leu Glu Val 
    1745                 1750                 1755             


Ile Asp  Ala Met Arg Ser Gln  Leu Gly Lys Ala Thr  Ala Leu Ala 
    1760                 1765                 1770             


Ile Met  Gly Asp Lys Leu Trp  Trp Ala Asp Gln Val  Ser Glu Lys 
    1775                 1780                 1785             


Met Gly  Thr Cys Ser Lys Ala  Asp Gly Ser Gly Ser  Val Val Leu 
    1790                 1795                 1800             


Arg Asn  Ser Thr Thr Leu Val  Met His Met Lys Val  Tyr Asp Glu 
    1805                 1810                 1815             


Ser Ile  Gln Leu Asp His Lys  Gly Thr Asn Pro Cys  Ser Val Asn 
    1820                 1825                 1830             


Asn Gly  Asp Cys Ser Gln Leu  Cys Leu Pro Thr Ser  Glu Thr Thr 
    1835                 1840                 1845             


Arg Ser  Cys Met Cys Thr Ala  Gly Tyr Ser Leu Arg  Ser Gly Gln 
    1850                 1855                 1860             


Gln Ala  Cys Glu Gly Val Gly  Ser Phe Leu Leu Tyr  Ser Val His 
    1865                 1870                 1875             


Glu Gly  Ile Arg Gly Ile Pro  Leu Asp Pro Asn Asp  Lys Ser Asp 
    1880                 1885                 1890             


Ala Leu  Val Pro Val Ser Gly  Thr Ser Leu Ala Val  Gly Ile Asp 
    1895                 1900                 1905             


Phe His  Ala Glu Asn Asp Thr  Ile Tyr Trp Val Asp  Met Gly Leu 
    1910                 1915                 1920             


Ser Thr  Ile Ser Arg Ala Lys  Arg Asp Gln Thr Trp  Arg Glu Asp 
    1925                 1930                 1935             


Val Val  Thr Asn Gly Ile Gly  Arg Val Glu Gly Ile  Ala Val Asp 
    1940                 1945                 1950             


Trp Ile  Ala Gly Asn Ile Tyr  Trp Thr Asp Gln Gly  Phe Asp Val 
    1955                 1960                 1965             


Ile Glu  Val Ala Arg Leu Asn  Gly Ser Phe Arg Tyr  Val Val Ile 
    1970                 1975                 1980             


Ser Gln  Gly Leu Asp Lys Pro  Arg Ala Ile Thr Val  His Pro Glu 
    1985                 1990                 1995             


Lys Gly  Tyr Leu Phe Trp Thr  Glu Trp Gly Gln Tyr  Pro Arg Ile 
    2000                 2005                 2010             


Glu Arg  Ser Arg Leu Asp Gly  Thr Glu Arg Val Val  Leu Val Asn 
    2015                 2020                 2025             


Val Ser  Ile Ser Trp Pro Asn  Gly Ile Ser Val Asp  Tyr Gln Asp 
    2030                 2035                 2040             


Gly Lys  Leu Tyr Trp Cys Asp  Ala Arg Thr Asp Lys  Ile Glu Arg 
    2045                 2050                 2055             


Ile Asp  Leu Glu Thr Gly Glu  Asn Arg Glu Val Val  Leu Ser Ser 
    2060                 2065                 2070             


Asn Asn  Met Asp Met Phe Ser  Val Ser Val Phe Glu  Asp Phe Ile 
    2075                 2080                 2085             


Tyr Trp  Ser Asp Arg Thr His  Ala Asn Gly Ser Ile  Lys Arg Gly 
    2090                 2095                 2100             


Ser Lys  Asp Asn Ala Thr Asp  Ser Val Pro Leu Arg  Thr Gly Ile 
    2105                 2110                 2115             


Gly Val  Gln Leu Lys Asp Ile  Lys Val Phe Asn Arg  Asp Arg Gln 
    2120                 2125                 2130             


Lys Gly  Thr Asn Val Cys Ala  Val Ala Asn Gly Gly  Cys Gln Gln 
    2135                 2140                 2145             


Leu Cys  Leu Tyr Arg Gly Arg  Gly Gln Arg Ala Cys  Ala Cys Ala 
    2150                 2155                 2160             


His Gly  Met Leu Ala Glu Asp  Gly Ala Ser Cys Arg  Glu Tyr Ala 
    2165                 2170                 2175             


Gly Tyr  Leu Leu Tyr Ser Glu  Arg Thr Ile Leu Lys  Ser Ile His 
    2180                 2185                 2190             


Leu Ser  Asp Glu Arg Asn Leu  Asn Ala Pro Val Gln  Pro Phe Glu 
    2195                 2200                 2205             


Asp Pro  Glu His Met Lys Asn  Val Ile Ala Leu Ala  Phe Asp Tyr 
    2210                 2215                 2220             


Arg Ala  Gly Thr Ser Pro Gly  Thr Pro Asn Arg Ile  Phe Phe Ser 
    2225                 2230                 2235             


Asp Ile  His Phe Gly Asn Ile  Gln Gln Ile Asn Asp  Asp Gly Ser 
    2240                 2245                 2250             


Arg Arg  Ile Thr Ile Val Glu  Asn Val Gly Ser Val  Glu Gly Leu 
    2255                 2260                 2265             


Ala Tyr  His Arg Gly Trp Asp  Thr Leu Tyr Trp Thr  Ser Tyr Thr 
    2270                 2275                 2280             


Thr Ser  Thr Ile Thr Arg His  Thr Val Asp Gln Thr  Arg Pro Gly 
    2285                 2290                 2295             


Ala Phe  Glu Arg Glu Thr Val  Ile Thr Met Ser Gly  Asp Asp His 
    2300                 2305                 2310             


Pro Arg  Ala Phe Val Leu Asp  Glu Cys Gln Asn Leu  Met Phe Trp 
    2315                 2320                 2325             


Thr Asn  Trp Asn Glu Gln His  Pro Ser Ile Met Arg  Ala Ala Leu 
    2330                 2335                 2340             


Ser Gly  Ala Asn Val Leu Thr  Leu Ile Glu Lys Asp  Ile Arg Thr 
    2345                 2350                 2355             


Pro Asn  Gly Leu Ala Ile Asp  His Arg Ala Glu Lys  Leu Tyr Phe 
    2360                 2365                 2370             


Ser Asp  Ala Thr Leu Asp Lys  Ile Glu Arg Cys Glu  Tyr Asp Gly 
    2375                 2380                 2385             


Ser His  Arg Tyr Val Ile Leu  Lys Ser Glu Pro Val  His Pro Phe 
    2390                 2395                 2400             


Gly Leu  Ala Val Tyr Gly Glu  His Ile Phe Trp Thr  Asp Trp Val 
    2405                 2410                 2415             


Arg Arg  Ala Val Gln Arg Ala  Asn Lys His Val Gly  Ser Asn Met 
    2420                 2425                 2430             


Lys Leu  Leu Arg Val Asp Ile  Pro Gln Gln Pro Met  Gly Ile Ile 
    2435                 2440                 2445             


Ala Val  Ala Asn Asp Thr Asn  Ser Cys Glu Leu Ser  Pro Cys Arg 
    2450                 2455                 2460             


Ile Asn  Asn Gly Gly Cys Gln  Asp Leu Cys Leu Leu  Thr His Gln 
    2465                 2470                 2475             


Gly His  Val Asn Cys Ser Cys  Arg Gly Gly Arg Ile  Leu Gln Asp 
    2480                 2485                 2490             


Asp Leu  Thr Cys Arg Ala Val  Asn Ser Ser Cys Arg  Ala Gln Asp 
    2495                 2500                 2505             


Glu Phe  Glu Cys Ala Asn Gly  Glu Cys Ile Asn Phe  Ser Leu Thr 
    2510                 2515                 2520             


Cys Asp  Gly Val Pro His Cys  Lys Asp Lys Ser Asp  Glu Lys Pro 
    2525                 2530                 2535             


Ser Tyr  Cys Asn Ser Arg Arg  Cys Lys Lys Thr Phe  Arg Gln Cys 
    2540                 2545                 2550             


Ser Asn  Gly Arg Cys Val Ser  Asn Met Leu Trp Cys  Asn Gly Ala 
    2555                 2560                 2565             


Asp Asp  Cys Gly Asp Gly Ser  Asp Glu Ile Pro Cys  Asn Lys Thr 
    2570                 2575                 2580             


Ala Cys  Gly Val Gly Glu Phe  Arg Cys Arg Asp Gly  Thr Cys Ile 
    2585                 2590                 2595             


Gly Asn  Ser Ser Arg Cys Asn  Gln Phe Val Asp Cys  Glu Asp Ala 
    2600                 2605                 2610             


Ser Asp  Glu Met Asn Cys Ser  Ala Thr Asp Cys Ser  Ser Tyr Phe 
    2615                 2620                 2625             


Arg Leu  Gly Val Lys Gly Val  Leu Phe Gln Pro Cys  Glu Arg Thr 
    2630                 2635                 2640             


Ser Leu  Cys Tyr Ala Pro Ser  Trp Val Cys Asp Gly  Ala Asn Asp 
    2645                 2650                 2655             


Cys Gly  Asp Tyr Ser Asp Glu  Arg Asp Cys Pro Gly  Val Lys Arg 
    2660                 2665                 2670             


Pro Arg  Cys Pro Leu Asn Tyr  Phe Ala Cys Pro Ser  Gly Arg Cys 
    2675                 2680                 2685             


Ile Pro  Met Ser Trp Thr Cys  Asp Lys Glu Asp Asp  Cys Glu His 
    2690                 2695                 2700             


Gly Glu  Asp Glu Thr His Cys  Asn Lys Phe Cys Ser  Glu Ala Gln 
    2705                 2710                 2715             


Phe Glu  Cys Gln Asn His Arg  Cys Ile Ser Lys Gln  Trp Leu Cys 
    2720                 2725                 2730             


Asp Gly  Ser Asp Asp Cys Gly  Asp Gly Ser Asp Glu  Ala Ala His 
    2735                 2740                 2745             


Cys Glu  Gly Lys Thr Cys Gly  Pro Ser Ser Phe Ser  Cys Pro Gly 
    2750                 2755                 2760             


Thr His  Val Cys Val Pro Glu  Arg Trp Leu Cys Asp  Gly Asp Lys 
    2765                 2770                 2775             


Asp Cys  Ala Asp Gly Ala Asp  Glu Ser Ile Ala Ala  Gly Cys Leu 
    2780                 2785                 2790             


Tyr Asn  Ser Thr Cys Asp Asp  Arg Glu Phe Met Cys  Gln Asn Arg 
    2795                 2800                 2805             


Gln Cys  Ile Pro Lys His Phe  Val Cys Asp His Asp  Arg Asp Cys 
    2810                 2815                 2820             


Ala Asp  Gly Ser Asp Glu Ser  Pro Glu Cys Glu Tyr  Pro Thr Cys 
    2825                 2830                 2835             


Gly Pro  Ser Glu Phe Arg Cys  Ala Asn Gly Arg Cys  Leu Ser Ser 
    2840                 2845                 2850             


Arg Gln  Trp Glu Cys Asp Gly  Glu Asn Asp Cys His  Asp Gln Ser 
    2855                 2860                 2865             


Asp Glu  Ala Pro Lys Asn Pro  His Cys Thr Ser Gln  Glu His Lys 
    2870                 2875                 2880             


Cys Asn  Ala Ser Ser Gln Phe  Leu Cys Ser Ser Gly  Arg Cys Val 
    2885                 2890                 2895             


Ala Glu  Ala Leu Leu Cys Asn  Gly Gln Asp Asp Cys  Gly Asp Ser 
    2900                 2905                 2910             


Ser Asp  Glu Arg Gly Cys His  Ile Asn Glu Cys Leu  Ser Arg Lys 
    2915                 2920                 2925             


Leu Ser  Gly Cys Ser Gln Asp  Cys Glu Asp Leu Lys  Ile Gly Phe 
    2930                 2935                 2940             


Lys Cys  Arg Cys Arg Pro Gly  Phe Arg Leu Lys Asp  Asp Gly Arg 
    2945                 2950                 2955             


Thr Cys  Ala Asp Val Asp Glu  Cys Ser Thr Thr Phe  Pro Cys Ser 
    2960                 2965                 2970             


Gln Arg  Cys Ile Asn Thr His  Gly Ser Tyr Lys Cys  Leu Cys Val 
    2975                 2980                 2985             


Glu Gly  Tyr Ala Pro Arg Gly  Gly Asp Pro His Ser  Cys Lys Ala 
    2990                 2995                 3000             


Val Thr  Asp Glu Glu Pro Phe  Leu Ile Phe Ala Asn  Arg Tyr Tyr 
    3005                 3010                 3015             


Leu Arg  Lys Leu Asn Leu Asp  Gly Ser Asn Tyr Thr  Leu Leu Lys 
    3020                 3025                 3030             


Gln Gly  Leu Asn Asn Ala Val  Ala Leu Asp Phe Asp  Tyr Arg Glu 
    3035                 3040                 3045             


Gln Met  Ile Tyr Trp Thr Asp  Val Thr Thr Gln Gly  Ser Met Ile 
    3050                 3055                 3060             


Arg Arg  Met His Leu Asn Gly  Ser Asn Val Gln Val  Leu His Arg 
    3065                 3070                 3075             


Thr Gly  Leu Ser Asn Pro Asp  Gly Leu Ala Val Asp  Trp Val Gly 
    3080                 3085                 3090             


Gly Asn  Leu Tyr Trp Cys Asp  Lys Gly Arg Asp Thr  Ile Glu Val 
    3095                 3100                 3105             


Ser Lys  Leu Asn Gly Ala Tyr  Arg Thr Val Leu Val  Ser Ser Gly 
    3110                 3115                 3120             


Leu Arg  Glu Pro Arg Ala Leu  Val Val Asp Val Gln  Asn Gly Tyr 
    3125                 3130                 3135             


Leu Tyr  Trp Thr Asp Trp Gly  Asp His Ser Leu Ile  Gly Arg Ile 
    3140                 3145                 3150             


Gly Met  Asp Gly Ser Ser Arg  Ser Val Ile Val Asp  Thr Lys Ile 
    3155                 3160                 3165             


Thr Trp  Pro Asn Gly Leu Thr  Leu Asp Tyr Val Thr  Glu Arg Ile 
    3170                 3175                 3180             


Tyr Trp  Ala Asp Ala Arg Glu  Asp Tyr Ile Glu Phe  Ala Ser Leu 
    3185                 3190                 3195             


Asp Gly  Ser Asn Arg His Val  Val Leu Ser Gln Asp  Ile Pro His 
    3200                 3205                 3210             


Ile Phe  Ala Leu Thr Leu Phe  Glu Asp Tyr Val Tyr  Trp Thr Asp 
    3215                 3220                 3225             


Trp Glu  Thr Lys Ser Ile Asn  Arg Ala His Lys Thr  Thr Gly Thr 
    3230                 3235                 3240             


Asn Lys  Thr Leu Leu Ile Ser  Thr Leu His Arg Pro  Met Asp Leu 
    3245                 3250                 3255             


His Val  Phe His Ala Leu Arg  Gln Pro Asp Val Pro  Asn His Pro 
    3260                 3265                 3270             


Cys Lys  Val Asn Asn Gly Gly  Cys Ser Asn Leu Cys  Leu Leu Ser 
    3275                 3280                 3285             


Pro Gly  Gly Gly His Lys Cys  Ala Cys Pro Thr Asn  Phe Tyr Leu 
    3290                 3295                 3300             


Gly Ser  Asp Gly Arg Thr Cys  Val Ser Asn Cys Thr  Ala Ser Gln 
    3305                 3310                 3315             


Phe Val  Cys Lys Asn Asp Lys  Cys Ile Pro Phe Trp  Trp Lys Cys 
    3320                 3325                 3330             


Asp Thr  Glu Asp Asp Cys Gly  Asp His Ser Asp Glu  Pro Pro Asp 
    3335                 3340                 3345             


Cys Pro  Glu Phe Lys Cys Arg  Pro Gly Gln Phe Gln  Cys Ser Thr 
    3350                 3355                 3360             


Gly Ile  Cys Thr Asn Pro Ala  Phe Ile Cys Asp Gly  Asp Asn Asp 
    3365                 3370                 3375             


Cys Gln  Asp Asn Ser Asp Glu  Ala Asn Cys Asp Ile  His Val Cys 
    3380                 3385                 3390             


Leu Pro  Ser Gln Phe Lys Cys  Thr Asn Thr Asn Arg  Cys Ile Pro 
    3395                 3400                 3405             


Gly Ile  Phe Arg Cys Asn Gly  Gln Asp Asn Cys Gly  Asp Gly Glu 
    3410                 3415                 3420             


Asp Glu  Arg Asp Cys Pro Glu  Val Thr Cys Ala Pro  Asn Gln Phe 
    3425                 3430                 3435             


Gln Cys  Ser Ile Thr Lys Arg  Cys Ile Pro Arg Val  Trp Val Cys 
    3440                 3445                 3450             


Asp Arg  Asp Asn Asp Cys Val  Asp Gly Ser Asp Glu  Pro Ala Asn 
    3455                 3460                 3465             


Cys Thr  Gln Met Thr Cys Gly  Val Asp Glu Phe Arg  Cys Lys Asp 
    3470                 3475                 3480             


Ser Gly  Arg Cys Ile Pro Ala  Arg Trp Lys Cys Asp  Gly Glu Asp 
    3485                 3490                 3495             


Asp Cys  Gly Asp Gly Ser Asp  Glu Pro Lys Glu Glu  Cys Asp Glu 
    3500                 3505                 3510             


Arg Thr  Cys Glu Pro Tyr Gln  Phe Arg Cys Lys Asn  Asn Arg Cys 
    3515                 3520                 3525             


Val Pro  Gly Arg Trp Gln Cys  Asp Tyr Asp Asn Asp  Cys Gly Asp 
    3530                 3535                 3540             


Asn Ser  Asp Glu Glu Ser Cys  Thr Pro Arg Pro Cys  Ser Glu Ser 
    3545                 3550                 3555             


Glu Phe  Ser Cys Ala Asn Gly  Arg Cys Ile Ala Gly  Arg Trp Lys 
    3560                 3565                 3570             


Cys Asp  Gly Asp His Asp Cys  Ala Asp Gly Ser Asp  Glu Lys Asp 
    3575                 3580                 3585             


Cys Thr  Pro Arg Cys Asp Met  Asp Gln Phe Gln Cys  Lys Ser Gly 
    3590                 3595                 3600             


His Cys  Ile Pro Leu Arg Trp  Arg Cys Asp Ala Asp  Ala Asp Cys 
    3605                 3610                 3615             


Met Asp  Gly Ser Asp Glu Glu  Ala Cys Gly Thr Gly  Val Arg Thr 
    3620                 3625                 3630             


Cys Pro  Leu Asp Glu Phe Gln  Cys Asn Asn Thr Leu  Cys Lys Pro 
    3635                 3640                 3645             


Leu Ala  Trp Lys Cys Asp Gly  Glu Asp Asp Cys Gly  Asp Asn Ser 
    3650                 3655                 3660             


Asp Glu  Asn Pro Glu Glu Cys  Ala Arg Phe Val Cys  Pro Pro Asn 
    3665                 3670                 3675             


Arg Pro  Phe Arg Cys Lys Asn  Asp Arg Val Cys Leu  Trp Ile Gly 
    3680                 3685                 3690             


Arg Gln  Cys Asp Gly Thr Asp  Asn Cys Gly Asp Gly  Thr Asp Glu 
    3695                 3700                 3705             


Glu Asp  Cys Glu Pro Pro Thr  Ala His Thr Thr His  Cys Lys Asp 
    3710                 3715                 3720             


Lys Lys  Glu Phe Leu Cys Arg  Asn Gln Arg Cys Leu  Ser Ser Ser 
    3725                 3730                 3735             


Leu Arg  Cys Asn Met Phe Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3740                 3745                 3750             


Glu Asp  Cys Ser Ile Asp Pro  Lys Leu Thr Ser Cys  Ala Thr Asn 
    3755                 3760                 3765             


Ala Ser  Ile Cys Gly Asp Glu  Ala Arg Cys Val Arg  Thr Glu Lys 
    3770                 3775                 3780             


Ala Ala  Tyr Cys Ala Cys Arg  Ser Gly Phe His Thr  Val Pro Gly 
    3785                 3790                 3795             


Gln Pro  Gly Cys Gln Asp Ile  Asn Glu Cys Leu Arg  Phe Gly Thr 
    3800                 3805                 3810             


Cys Ser  Gln Leu Cys Asn Asn  Thr Lys Gly Gly His  Leu Cys Ser 
    3815                 3820                 3825             


Cys Ala  Arg Asn Phe Met Lys  Thr His Asn Thr Cys  Lys Ala Glu 
    3830                 3835                 3840             


Gly Ser  Glu Tyr Gln Val Leu  Tyr Ile Ala Asp Asp  Asn Glu Ile 
    3845                 3850                 3855             


Arg Ser  Leu Phe Pro Gly His  Pro His Ser Ala Tyr  Glu Gln Ala 
    3860                 3865                 3870             


Phe Gln  Gly Asp Glu Ser Val  Arg Ile Asp Ala Met  Asp Val His 
    3875                 3880                 3885             


Val Lys  Ala Gly Arg Val Tyr  Trp Thr Asn Trp His  Thr Gly Thr 
    3890                 3895                 3900             


Ile Ser  Tyr Arg Ser Leu Pro  Pro Ala Ala Pro Pro  Thr Thr Ser 
    3905                 3910                 3915             


Asn Arg  His Arg Arg Gln Ile  Asp Arg Gly Val Thr  His Leu Asn 
    3920                 3925                 3930             


Ile Ser  Gly Leu Lys Met Pro  Arg Gly Ile Ala Ile  Asp Trp Val 
    3935                 3940                 3945             


Ala Gly  Asn Val Tyr Trp Thr  Asp Ser Gly Arg Asp  Val Ile Glu 
    3950                 3955                 3960             


Val Ala  Gln Met Lys Gly Glu  Asn Arg Lys Thr Leu  Ile Ser Gly 
    3965                 3970                 3975             


Met Ile  Asp Glu Pro His Ala  Ile Val Val Asp Pro  Leu Arg Gly 
    3980                 3985                 3990             


Thr Met  Tyr Trp Ser Asp Trp  Gly Asn His Pro Lys  Ile Glu Thr 
    3995                 4000                 4005             


Ala Ala  Met Asp Gly Thr Leu  Arg Glu Thr Leu Val  Gln Asp Asn 
    4010                 4015                 4020             


Ile Gln  Trp Pro Thr Gly Leu  Ala Val Asp Tyr His  Asn Glu Arg 
    4025                 4030                 4035             


Leu Tyr  Trp Ala Asp Ala Lys  Leu Ser Val Ile Gly  Ser Ile Arg 
    4040                 4045                 4050             


Leu Asn  Gly Thr Asp Pro Ile  Val Ala Ala Asp Ser  Lys Arg Gly 
    4055                 4060                 4065             


Leu Ser  His Pro Phe Ser Ile  Asp Val Phe Glu Asp  Tyr Ile Tyr 
    4070                 4075                 4080             


Gly Val  Thr Tyr Ile Asn Asn  Arg Val Phe Lys Ile  His Lys Phe 
    4085                 4090                 4095             


Gly His  Ser Pro Leu Val Asn  Leu Thr Gly Gly Leu  Ser His Ala 
    4100                 4105                 4110             


Ser Asp  Val Val Leu Tyr His  Gln His Lys Gln Pro  Glu Val Thr 
    4115                 4120                 4125             


Asn Pro  Cys Asp Arg Lys Lys  Cys Glu Trp Leu Cys  Leu Leu Ser 
    4130                 4135                 4140             


Pro Ser  Gly Pro Val Cys Thr  Cys Pro Asn Gly Lys  Arg Leu Asp 
    4145                 4150                 4155             


Asn Gly  Thr Cys Val Pro Val  Pro Ser Pro Thr Pro  Pro Pro Asp 
    4160                 4165                 4170             


Ala Pro  Arg Pro Gly Thr Cys  Asn Leu Gln Cys Phe  Asn Gly Gly 
    4175                 4180                 4185             


Ser Cys  Phe Leu Asn Ala Arg  Arg Gln Pro Lys Cys  Arg Cys Gln 
    4190                 4195                 4200             


Pro Arg  Tyr Thr Gly Asp Lys  Cys Glu Leu Asp Gln  Cys Trp Glu 
    4205                 4210                 4215             


His Cys  Arg Asn Gly Gly Thr  Cys Ala Ala Ser Pro  Ser Gly Met 
    4220                 4225                 4230             


Pro Thr  Cys Arg Cys Pro Thr  Gly Phe Thr Gly Pro  Lys Cys Thr 
    4235                 4240                 4245             


Gln Gln  Val Cys Ala Gly Tyr  Cys Ala Asn Asn Ser  Thr Cys Thr 
    4250                 4255                 4260             


Val Asn  Gln Gly Asn Gln Pro  Gln Cys Arg Cys Leu  Pro Gly Phe 
    4265                 4270                 4275             


Leu Gly  Asp Arg Cys Gln Tyr  Arg Gln Cys Ser Gly  Tyr Cys Glu 
    4280                 4285                 4290             


Asn Phe  Gly Thr Cys Gln Met  Ala Ala Asp Gly Ser  Arg Gln Cys 
    4295                 4300                 4305             


Arg Cys  Thr Ala Tyr Phe Glu  Gly Ser Arg Cys Glu  Val Asn Lys 
    4310                 4315                 4320             


Cys Ser  Arg Cys Leu Glu Gly  Ala Cys Val Val Asn  Lys Gln Ser 
    4325                 4330                 4335             


Gly Asp  Val Thr Cys Asn Cys  Thr Asp Gly Arg Val  Ala Pro Ser 
    4340                 4345                 4350             


Cys Leu  Thr Cys Val Gly His  Cys Ser Asn Gly Gly  Ser Cys Thr 
    4355                 4360                 4365             


Met Asn  Ser Lys Met Met Pro  Glu Cys Gln Cys Pro  Pro His Met 
    4370                 4375                 4380             


Thr Gly  Pro Arg Cys Glu Glu  His Val Phe Ser Gln  Gln Gln Pro 
    4385                 4390                 4395             


Gly His  Ile Ala Ser Ile Leu  Ile Pro Leu Leu Leu  Leu Leu Leu 
    4400                 4405                 4410             


Leu Val  Leu Val Ala Gly Val  Val Phe Trp Tyr Lys  Arg Arg Val 
    4415                 4420                 4425             


Gln Gly  Ala Lys Gly Phe Gln  His Gln Arg Met Thr  Asn Gly Ala 
    4430                 4435                 4440             


Met Asn  Val Glu Ile Gly Asn  Pro Thr Tyr Lys Met  Tyr Glu Gly 
    4445                 4450                 4455             


Gly Glu  Pro Asp Asp Val Gly  Gly Leu Leu Asp Ala  Asp Phe Ala 
    4460                 4465                 4470             


Leu Asp  Pro Asp Lys Pro Thr  Asn Phe Thr Asn Pro  Val Tyr Ala 
    4475                 4480                 4485             


Thr Leu  Tyr Met Gly Gly His  Gly Ser Arg His Ser  Leu Ala Ser 
    4490                 4495                 4500             


Thr Asp  Glu Lys Arg Glu Leu  Leu Gly Arg Gly Pro  Glu Asp Glu 
    4505                 4510                 4515             


Ile Gly  Asp Pro Leu Ala 
    4520                 


<210>  2
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe Ala Cys Arg Asp 
1               5                   10                  15      


Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp Gly Glu Arg Asp 
            20                  25                  30          


Cys Pro Asp Gly Ser Asp Glu Ala Pro Glu Ile Cys Pro Gln Ser Lys 
        35                  40                  45              


Ala Gln Arg Cys Gln Pro Asn Glu His Asn Cys Leu Gly Thr Glu Leu 
    50                  55                  60                  


Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln Asp Cys Met Asp 
65                  70                  75                  80  


Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu Gln Gly Asn Cys Ser 
                85                  90                  95      


Arg Leu Gly Cys Gln His His Cys Val Pro Thr Leu Asp Gly Pro Thr 
            100                 105                 110         


Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp Gly Lys Thr Cys 
        115                 120                 125             


Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys Ser Gln Leu Cys 
    130                 135                 140                 


Thr Asn Thr Asp Gly Ser Phe Ile Cys Gly Cys Val Glu Gly Tyr Leu 
145                 150                 155                 160 


Leu Gln Pro Asp Asn Arg Ser Cys Lys Ala Lys Asn 
                165                 170         


<210>  3
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Phe Ile Cys Gly Cys Val Glu Gly Tyr Leu Leu Gln Pro Asp Asn Arg 
1               5                   10                  15      


Ser Cys Lys Ala Lys Asn 
            20          


<210>  4
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
ccggtctgag ttctggtgcc gactactcga gtagtcggca ccagaactca gatttttg         58


<210>  5
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
ccggacagct tcctgagggc taattctcga gaattagccc tcaggaagct gttttttg         58


<210>  6
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
ccgggatccg tgtgaaccgc tttaactcga gttaaagcgg ttcacacgga tctttttg         58


<210>  7
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Ile Asp Ala Pro Lys Thr Cys Ser Pro Lys Gln Phe Ala Cys Arg Asp 
1               5                   10                  15      


Gln Ile Thr Cys Ile Ser Lys Gly Trp 
            20                  25  


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Arg Asp Gln Ile Thr Cys Ile Ser Lys Gly Trp Arg Cys Asp Gly Glu 
1               5                   10                  15      


Arg Asp Cys Pro Asp Gly Ser Asp Glu 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Arg Cys Asp Gly Glu Arg Asp Cys Pro Asp Gly Ser Asp Glu Ala Pro 
1               5                   10                  15      


Glu Ile Cys Pro Gln Ser Lys Ala Gln 
            20                  25  


<210>  10
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Ala Pro Glu Ile Cys Pro Gln Ser Lys Ala Gln Arg Cys Gln Pro Asn 
1               5                   10                  15      


Glu His Asn Cys Leu Gly Thr Glu Leu 
            20                  25  


<210>  11
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Arg Cys Gln Pro Asn Glu His Asn Cys Leu Gly Thr Glu Leu Cys Val 
1               5                   10                  15      


Pro Met Ser Arg Leu Cys Asn Gly Val 
            20                  25  


<210>  12
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Thr Glu Leu Cys Val Pro Met Ser Arg Leu Cys Asn Gly Val Gln Asp 
1               5                   10                  15      


Cys Met Asp Gly Ser Asp Glu Gly Pro 
            20                  25  


<210>  13
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Gln Asp Cys Met Asp Gly Ser Asp Glu Gly Pro His Cys Arg Glu Leu 
1               5                   10                  15      


Gln Gly Asn Cys Ser Arg Leu Gly Cys 
            20                  25  


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

His Cys Arg Glu Leu Gln Gly Asn Cys Ser Arg Leu Gly Cys Gln His 
1               5                   10                  15      


His Cys Val Pro Thr Leu Asp Gly Pro 
            20                  25  


<210>  15
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Gln His His Cys Val Pro Thr Leu Asp Gly Pro Thr Cys Tyr Cys Asn 
1               5                   10                  15      


Ser Ser Phe Gln Leu Gln Ala Asp Gly Lys Thr 
            20                  25          


<210>  16
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Thr Cys Tyr Cys Asn Ser Ser Phe Gln Leu Gln Ala Asp Gly Lys Thr 
1               5                   10                  15      


Cys Lys Asp Phe Asp Glu Cys Ser Val 
            20                  25  


<210>  17
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Lys Thr Cys Lys Asp Phe Asp Glu Cys Ser Val Tyr Gly Thr Cys Ser 
1               5                   10                  15      


Gln Leu Cys Thr Asn Thr Asp Gly Ser 
            20                  25  


<210>  18
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Tyr Gly Thr Cys Ser Gln Leu Cys Thr Asn Thr Asp Gly Ser Phe Ile 
1               5                   10                  15      


Cys Gly Cys Val Glu Gly Tyr Leu Leu 
            20                  25  


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Phe Ile Cys Gly Cys Val Glu Gly Tyr Leu Leu 
1               5                   10      


<210>  20
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
atgaatctac ttctgatcct tacctttgtt gcagctgctg ttgctgcccc ctttgatgat       60

gatgacaaga tcgttggggg ctacatctgt gaggagaatt ctgtccccta ccaggtgtcc      120

ttgaattctg gctaccactt ctgcggtggc tccctcatca gcgaacagtg ggtggtgtca      180

gcaggtcact gctacaagtc ggcaattaac tcaaaattat caggaagagg gtgtgaatat      240

caccgcatcc aggtgagact gggagagcac aacatcgaag tcctggaggg gaatgaacag      300

ttcatcaatg cggccaagat catccgccac cccaaataca acagccggac tctggacaat      360

gacatcctgc tgatcaagct ctcctcacct gccgtcatca attcccgcgt gtccgccatc      420

tctctgccca ctgcccctcc agctgctggc accgagtccc tcatctccgg ctggggcaac      480

actctgagtt ctggtgccga ctacccagac gagctgcagt gcctggatgc tcctgtgctg      540

agccaggctg agtgtgaagc ctcctaccct gagaagatta ccaacaacat gttctgtgtg      600

ggcttcctcg agggaggcaa ggattcctgc cagggtgatt ctggtggccc tgtggtctcc      660

aatggagagc tccaaggaat tgtctcctgg ggctatggct gtgcccagaa gaacaggcct      720

ggagtctaca ccaaggtcta caactatgtg gactggatta aggacaccat agctgccaac      780

agctaa                                                                 786


<210>  21
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
atgaatctac ttctgatcct tacctttgtt gcagctgctg ttgctgcccc ctttgatgat       60

gatgacaaga tcgttggggg ctacatctgt gaggagaatt ctgtccccta ccaggtgtcc      120

ttgaattctg gctaccactt ctgcggtggc tccctcatca gcgaacagtg ggtggtgtca      180

gcaggtcact gctacaagtc ggcaattaac tcaaaattat caggaagagg gtgtgaatat      240

caccgcatcc aggtgagact gggagagcac aacatcgaag tcctggaggg gaatgaacag      300

ttcatcaatg cggccaagat catccgccac cccaaataca acagccggac tctggacaat      360

gacatcctgc tgatcaagct ctcctcacct gccgtcatca attcccgcgt gtccgccatc      420

tctctgccca ctgcccctcc agctgctggc accgagtccc tcatctccgg ctggggcaac      480

actctgagtt ctggtgccga ctacccagac gagctgcagt gcctggatgc tcctgtgctg      540

agccaggctg agtgtgaagc ctcctaccct gagaagatta ccaacaacat gttctgtgtg      600

ggcttcctcg agcgaggcaa ggattcctgc cagggtgatt ctggtggccc tgtggtctcc      660

aatggagagc tccaaggaat tgtctcctgg ggctatggct gtgcccagaa gaacaggcct      720

ggagtctaca ccaaggtcta caactatgtg gactggatta aggacaccat agctgccaac      780

agctaa                                                                 786


<210>  22
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
atgaatctac ttctgatcct tacctttgtt gcagctgctg ttgctgcccc ctttgatgat       60

gatgacaaga tcgttggggg ctacatctgt gaggagaatt ctgtccccta ccaggtgtcc      120

ttgaattctg gctaccactt ctgcggtggc tccctcatca gcgaacagtg ggtggtgtca      180

gcaggtcact gctacaagtc ggcaattaac tcaaaattat caggaagagg gtgtgaatat      240

caccgcatcc aggtgagact gggagagcac aacatcgaag tcctggaggg gaatgaacag      300

ttcatcaatg cggccaagat catccgccac cccaaataca acagccggac tctggacaat      360

gacatcctgc tgatcaagct ctcctcacct gccgtcatca attcccgcgt gtccgccatc      420

tctctgccca ctgcccctcc agctgctggc accgagtccc tcatctccgg ctggggcaac      480

actctgagtt ctggtgccga ctacccagac gagctgcagt gcctggatgc tcctgtgctg      540

agccaggctg agtgtgaagc ctcctaccct gagaagatta ccaacaacat gttctgtgtg      600

ggcttcctcg agggaggcaa ggattcctgc cagggtgatg ctggtggccc tgtggtctcc      660

aatggagagc tccaaggaat tgtctcctgg ggctatggct gtgcccagaa gaacaggcct      720

ggagtctaca ccaaggtcta caactatgtg gactggatta aggacaccat agctgccaac      780

agctaa                                                                 786


<210>  23
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  23
atgaatctac ttctgatcct tacctttgtt gcagctgctg ttgctgcccc ctttgatgat       60

gatgacaaga tcgttggggg ctacatctgt gaggagaatt ctgtccccta ccaggtgtcc      120

ttgaattctg gctaccactt ctgcggtggc tccctcatca gcgaacagtg ggtggtgtca      180

gcaggtcact gctacaagtc ggcaattaac tcaaaattat caggaagagg gtgtgaatat      240

caccgcatcc aggtgagact gggagagcac aacatcgaag tcctggaggg gaatgaacag      300

ttcatcaatg cggccaagat catccgccac cccaaataca acagccggac tctggacaat      360

gacatcctgc tgatcaagct ctcctcacct gccgtcatca attcccgcgt gtccgccatc      420

tctctgccca ctgcccctcc agctgctggc accgagtccc tcatctccgg ctggggcaac      480

actctgagtt ctggtgccga ctacccagac gagctgcagt gcctggatgc tcctgtgctg      540

agccaggctg agtgtgaagc ctcctaccct gagaagatta ccaacaacat gttctgtgtg      600

ggcttcctcg agggaggcaa ggattcctgc cagggtgata ctggtggccc tgtggtctcc      660

aatggagagc tccaaggaat tgtctcctgg ggctatggct gtgcccagaa gaacaggcct      720

ggagtctaca ccaaggtcta caactatgtg gactggatta aggacaccat agctgccaac      780

agctaa                                                                 786


<210>  24
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  24
atgaatctac ttctgatcct tacctttgtt gcagctgctg ttgctgcccc ctttgatgat       60

gatgacaaga tcgttggggg ctacatctgt gaggagaatt ctgtccccta ccaggtgtcc      120

ttgaattctg gctaccactt ctgcggtggc tccctcatca gcgaacagtg ggtggtgtca      180

gcaggtcact gctacaagtc ggcaattaac tcaaaattat caggaagagg gtgtgaatat      240

caccgcatcc aggtgagact gggagagcac aacatcgaag tcctggaggg gaatgaacag      300

ttcatcaatg cggccaagat catccgccac cccaaataca acagccggac tctggacaat      360

gacatcctgc tgatcaagct ctcctcacct gccgtcatca attcccgcgt gtccgccatc      420

tctctgccca ctgcccctcc agctgctggc accgagtccc tcatctccgg ctggggcaac      480

actctgagtt ctggtgccga ctacccagac gagctgcagt gcctggatgc tcctgtgctg      540

agccaggctg agtgtgaagc ctcctaccct gagaagatta ccaacaacat gttctgtgtg      600

ggcttcctcg agggaggcaa ggattcctgc cagggtgatt gtggtggccc tgtggtctcc      660

aatggagagc tccaaggaat tgtctcctgg ggctatggct gtgcccagaa gaacaggcct      720

ggagtctaca ccaaggtcta caactatgtg gactggatta aggacaccat agctgccaac      780

agctaa                                                                 786


<210>  25
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala Ala 
1               5                   10                  15      


Pro Phe Asp Asp Asp Asp Lys Ile Val Gly Gly Tyr Ile Cys Glu Glu 
            20                  25                  30          


Asn Ser Val Pro Tyr Gln Val Ser Leu Asn Ser Gly Tyr His Phe Cys 
        35                  40                  45              


Gly Gly Ser Leu Ile Ser Glu Gln Trp Val Val Ser Ala Gly His Cys 
    50                  55                  60                  


Tyr Lys Ser Ala Ile Asn Ser Lys Leu Ser Gly Arg Gly Cys Glu Tyr 
65                  70                  75                  80  


His Arg Ile Gln Val Arg Leu Gly Glu His Asn Ile Glu Val Leu Glu 
                85                  90                  95      


Gly Asn Glu Gln Phe Ile Asn Ala Ala Lys Ile Ile Arg His Pro Lys 
            100                 105                 110         


Tyr Asn Ser Arg Thr Leu Asp Asn Asp Ile Leu Leu Ile Lys Leu Ser 
        115                 120                 125             


Ser Pro Ala Val Ile Asn Ser Arg Val Ser Ala Ile Ser Leu Pro Thr 
    130                 135                 140                 


Ala Pro Pro Ala Ala Gly Thr Glu Ser Leu Ile Ser Gly Trp Gly Asn 
145                 150                 155                 160 


Thr Leu Ser Ser Gly Ala Asp Tyr Pro Asp Glu Leu Gln Cys Leu Asp 
                165                 170                 175     


Ala Pro Val Leu Ser Gln Ala Glu Cys Glu Ala Ser Tyr Pro Gly Lys 
            180                 185                 190         


Ile Thr Asn Asn Met Phe Cys Val Gly Phe Leu Glu Gly Gly Lys Asp 
        195                 200                 205             


Ser Cys Gln Gly Asp Ser Gly Gly Pro Val Val Ser Asn Gly Glu Leu 
    210                 215                 220                 


Gln Gly Ile Val Ser Trp Gly Tyr Gly Cys Ala Gln Lys Asn Arg Pro 
225                 230                 235                 240 


Gly Val Tyr Thr Lys Val Tyr Asn Tyr Val Asp Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Ala Ala Asn Ser 
            260     


