                         SEQUENCE LISTING

<110>  The Research Foundation of State University of New York
 
<120>  Methods of Inhibiting Fungal Ceramide Synthase for Treatment of 
       Cryptoccus Neoformans Infection

<130>  90367-PCT/GJG/LPT

<150>  62/620,080
<151>  2018-01-22

<150>  62/473,742
<151>  2017-03-20

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1470
<212>  DNA
<213>  Cryptococcus neoformans

<400>  1
gttacgtgaa ctgtccagtc cacagccaag tgcagccttt tccttccccg tcaaaaacca       60

cccccccctc cccccctgca caggtaacca aacacccacg agctggcttc gtggactgca      120

ctgttccctt ccccccacgc gacatccgca cctgctgcag cagcgcactc cgccagcatg      180

gcgtgcaacc tcaccacctc ccccctcccc tccctcctcc actcctatgt cccacagtcg      240

ctgcggccct ttgtcaccct gtcgtatccc atcacagacc cgctcgccca cccgtccgcg      300

cagacactgt acgacaaggg cccgcaggat gcgtgcttgg tgctcttctg ggcgctggcg      360

ttcaccctgc tccgggaggc gttcatgaag ggtgtcttct ctccctttat gagaatatgt      420

ctgccaagcc cgccacagat caagggacag gagagagaat atgcaaaggc caggaagaag      480

agggagcata ccgtcacgag gtttgcagag caaggctgga gctggctgta ttgctctata      540

tattggacat ttggcgtgat tgtcctccgc cagaatccct ctccaacatc tcccgaacag      600

ctctggggca catacccggc cgtccctctc ccggcactca ccaagtttta ctatctctcc      660

cagctcggtt ggtggttcca ccagctgctc gttatcaact gcgagaagcg aagaaaagat      720

cattggcaga tgtttgggca ccacatattg actattactt tggttgtggg gagctacgtc      780

atgaacttta cctcggtcgg tgtcgttatc cactgtctta tggacttttg cgacatcctc      840

ttaccactcg ccaaaatgtt tcgctacctc tccctctcca ccctctgcga cctcacattc      900

gtcgtctttc tcatctcatg gttcatcact cgtgaagccg gtctcttcct cgtcatccgc      960

agcacctatg tggacgcgcc caaattcatc ccctttgaat gggctcccga acaaggccga     1020

ttccttactt acagggttta cctcggcttt gtcgccatgc tctccatcct ctggatcctc     1080

gccacggcgt ggttttacat ggcttgcaac gtcgcgatcc gcgtggtacg aggtatgggc     1140

gctgaagact cgagaagtga tgatgagtcc gaagaggatg cgttggagca agtgccagag     1200

agtgtaggtg cttcaactgc gaccaggtct gaggtagaag aggatctgcg aaaacgaaaa     1260

ttattttctc aacgagggac ttgatgatag attatttttg atatgaaggg acgtttttca     1320

aaaaaaaaaa aaaaggaaaa aaaaaataga cacaaaaaaa gatcagtgta tacctctaaa     1380

atagattgaa aaagtatcct caatttttta acgcaggatt ttttaacgcc gggatgatca     1440

tcacatgcat tagacgtcat atataaaaca                                      1470


<210>  2
<211>  1404
<212>  DNA
<213>  Aspergillus fumigatus

<400>  2
atggcaaaag acgaatccac gcgatcgcaa tccgtttcgg agcttaatac ttgtgtgtcc       60

accagtcacc gaactgctgc caaagacgcg acctttcgag aatggatgga cgcgaatcaa      120

attggtatgc gtcttttctc caacttgcct tggagttgga ctcgatggct gaccgttgct      180

ctgtatgcgt atctaggagt ctcattgact attcttggca cccttttggc tgctcataac      240

ctctacccca ccctccggcc atacacggcg ccgttcttcg aattgtcgta ctaccaacct      300

tccgaagggg tctatgtcca aggatttgac gatgtgtact ttgtcgtcag ctccgccatc      360

acgttcaccg ccgtccgagc gattgccatt gaatggatct tcagaccagc cgccagatat      420

gcgggattga agcggaaggc ttcaaatcgt tttgccgagc aggcgtggat gtggatgtac      480

tatgcgttct tctggacgtt tggaatgtat atctggacaa actcctatta ctggatggat      540

ttcaaggcaa tttgggctca atggcccgcg cggggtatct ctgcaaacct gaagtggtat      600

ctgctggcac agctgtcatt ctggttccag cagatcctgg ttatcaacat ggaagaaagg      660

agaaaagatc actaccagat gttgactcac cacatcatca ccagcactct cttgacgtcc      720

gcctatattt acggttttta taacgtttca aacgtggtcc tgtgtctgat ggacattgtc      780

gacctgttgc tgcctactgc caagattctc aagtacttca agttcgagct ttgctgcaac      840

atcaccttcg gcctgttcat ggtgacctgg ttgattacac gtcacatttt ctacccacta      900

ctctgctggt ctatctacaa ggatgtccct gatgccatgg cctacggctg ctactccggt      960

agcaccgcgg aaatgatttc aaccgatggg tacccgaacc gattccgcta cctttttaac     1020

cccttcttgg acatcaatgg ccccatctgc atgaatcgca ctgtcaagtg gattttcctt     1080

ggttttcttc tggcgttgca attgctctct ctcatatggt tcgtgatggt tgtccgcgtg     1140

gctgtaaatg tgctccgaac cggaaatgcc gaagacactc gaagcgacgg cgaagaggaa     1200

gaggaagaag tcgaagtccg acctgtgggc aaggacgcgc tcaacaacaa cccagtcggt     1260

gtggacgggg cgaatgccga ctggcgtcga gcctcgagcg gctcagctag cgtgcgacct     1320

cgcgcgcggg gacgaatccc acttggtgac cagagcgatc gcaaggccct ccttggcagg     1380

atcggatgcg acaagccgac gtag                                            1404


<210>  3
<211>  1135
<212>  DNA
<213>  Candida auris

<400>  3
atgaagctca cagcctcgca aaggcaaaag ctgaatcagc gtgtgcgtgc tttgagcgat       60

gaatcaagga ccgatgttgc aataatacgc aaaatgtttg ttgcatttaa ggaattgtca      120

ttcagacaca cttggataaa tccgttcatt atcctttcgg tgttctacat ttcgtacttt      180

ggtactactg aatcaaaccc gattcatgaa aatctcaaaa aactcattaa accatcgtac      240

catatcgttg gaacagatca gtatggaaaa ggtgtgaatg acttctattt tgttgcattt      300

tacgctcttt tttttacatt tttgagagaa tttatgatgt gcgtaatttt gaggcctctc      360

gcgggcatgt taggtgtcac aaggccgcac aaagttaata gatttatgga gcaaagttac      420

gcaatgttct attatggttt gtctggcccc tatggacttt atgttatgtc cagaatgcca      480

ctttggtttt ttgagactac tcctttgtac gaaagttacc ctcacaagac gcatgattgg      540

cttttcaaag tatactacct cggacaggcg gccttttggg ttcaacaatc cgttgttcta      600

attctccagc ttgaaaaacc tagaaaggac ttccatgagc ttattcttca ccacattatc      660

acgattgcgc tcatttggtt gtcctacaga tttcatttca cgtggatggg gctcgaaatt      720

tatgttacca tggatgtctc ggactttttt ttagcaactt cgaaaacgtt gaactatctc      780

gattcgattc tcacagggcc atttttaata ggctttgtat ttatttggat ctatctcaga      840

cactatgtga atctaaaaat attatggtct gtactcactg agtttaaaac cgttggtgag      900

tgggagttga attgggaaac gcagcaatac aaatgttgga tttctcagcc cattgtcttt      960

gggctcattt ttgcattgca agtcttgaat gcttattggt tattcctaat attgagaatt     1020

ttgtatagat acgttgttgg cggcgttaaa gcagacgaaa gaagtgagtc agaagatgag     1080

gatgaagatg aacctcctca gaaggataaa tctgtatcag aaggataaat ctgta          1135


<210>  4
<211>  1434
<212>  DNA
<213>  Balstomyces dermatitidis

<400>  4
gccgcaaaaa tccttaaata cctcggatac gaacgcgcct gcaccgtagg gttcatagtc       60

ttcctcgtca cctgggtaat atcgcgccac atcatctata acctcctttg gtggtctatc      120

tacgtcaacg tccccgacgt tatgccctac ggctgctact ccgccacgac aacgaagatg      180

atctcacccg ctgccaacac caccctggac aacggcgccg catccataga cctaaacaac      240

tggaaccacc tcctccaccc attccaagac ctgggcggcc gcatctgcat gagcccgcgc      300

atcaaatggg tgttcctctc tttcttgctt ttcctacaga tcctcgccct tatatggttc      360

acgatgattc tgcgtgtggc tgttaaggtg ctgaagagcg ggtcagcgga ggactcacgg      420

agcgatgacg aaggggagga ggaagaagaa gtgaattcgg agactacgag gatgggtgga      480

aatgggacaa ttgctggtgt tcgtgatggg attaatggta atgggaccgc gatcgtttcg      540

ggcagttcta cttcatcgtc aaccgcgcag ggtcatcatc ctgtgcgaat tcggacgggt      600

cggggccggg ttacgttgag tgatcagaat gaccggaaag cgttgttggg gcgcattggg      660

tgtgataaac cctcatgcct ttggtaccat tctaaatact ggaataattt ccgcgagata      720

tggaccgact ggccttccag agacatctcc ggcgtcttca agtggtactg cctgacacag      780

ctggcgttct ggttccaaca gatcatcgtc atcaacattg aggagaggcg gaaggattac      840

tatcagatgc tggttcacca catcgtcaca agcactcttt taggctctgc ttatgtctat      900

ggcttctaca acgtcgccaa tgtcgtcctc tgtatcatgg acatcgtcga tttcctgctg      960

ccggtaagac gcataggtat ctgcatcacc atcctcacaa tgatattcgc cctgcacaat     1020

ctctatccat ctctaagacc gtacacctcc cctttcctgc aattaccgca ctaccagcct     1080

gagaagggta catatgtcca gggttgggat gatctttatt ttgccatggg aggcgttctg     1140

gcattcactg ccgtcagggc gatcgctgtc gagtggatct tccagcccct tgcccgaaga     1200

tacggtctga agcataaggc cgccgtccgg ttggcggaac aaggctggct tcttgtttac     1260

tattttggtt tctggactta cggagtggta atggtgaaga ccctctccag ccagcccaat     1320

tcagtttccg aagtcaatgc ctgtgtttct cccatggaag gctgtcgggc ggccaagatg     1380

aagccaaaag aggagaccaa ttttcgacaa tgggtgctgc aaaatcagat aggt           1434


<210>  5
<211>  1395
<212>  DNA
<213>  Histoplasma capsulatum

<400>  5
gccgcaaaaa tcctcaaata cctcgggtat gaacgcgcct gcacggcggg cttcatagtc       60

ttccttgtca cttgggtaat ctcccgccat atcgtctaca atctcctctg gtggtctatc      120

tatatcaacg tcccagacgt tatgccctac ggttgctact ctgcaactac aaccgagatg      180

atttcacccg ctgcaaacgc caccctagac ggcgccgcat ccatagacct aaacaactgg      240

agccacctcc tccagccatt ccgagatctg ggcggccgca tttgcatgag cccacgcgtc      300

aaatgggttt tcctctcttt cctgttattc ctgcagatcc tcgcgatttt atggttcacg      360

atgattctac gtgtagctgt caaggtgctg aagagtgggt cggcagagga ttcgcggagt      420

gatgatgagg aagaagatga ggaagaggtg gattcgcaaa atttaaggac ggaagggaat      480

gctggtgtta gggatggtgg tcgtgggaat ggcacggcga tcgtgtctgg gagttctgtc      540

tcatcatccg cggggcaagg tcatcatccc gtgcgaatca ggaccggacg aggtcgagtt      600

accttgagtg atcagaatga tcggaaagcg ctgttgggac ggattgggtg tgataaaccc      660

acgttccttt ggtacaattc taagtactgg tataatttcc gcgagatatg gaccgattgg      720

ccctccagag atatctccgg tatcttcaaa tggtactgtc tgacgcagct ggctttctgg      780

ttccaacaga tccttgttat caacattgag gagagacgca aagattattg tcagatgctg      840

gtccatcaca tagtcacaag cacgctttta gggtctgctt acgtctatgg cttttataat      900

gtcgccaacg tcgtcctctg cattatggac attgtcgatt ttctgctgcc ggtaagcaag      960

ataggtatct gcatcactac cctcacaatg atattcgccc ttcacaacct ctacccgtcg     1020

ctgaggccgt acacctcccc cttcctgcaa ttgccgcact accagcctga gaagggtaca     1080

tatgtccagg gctgggatga tatctatttt gttatggggg gcgttctcgc tttcaccgcc     1140

gtccgagcga ttgccatcga atggatcttc cagccccttg cccgcagata cggcttgaaa     1200

cacaaagcat ctgtccggct ggcggagcaa ggctggattc tcgtttatta ttttggcttc     1260

tgggcttacg gagtgatgac gaaggtgaag ccaacgccgg agaccaattt tcgacaatgg     1320

gtgctgcaga accagatagg tacaatatac aaatgttcct caatctttgt cccgcccaat     1380

atcccatcac taaaa                                                      1395


<210>  6
<211>  1666
<212>  DNA
<213>  Coccidioides immitis

<400>  6
aactcttact cttcatatgc tttgtttctg ttcggtcggt tctcagtacc tttccggagt       60

cacaagtagc tcctttccgc cgtctgagga aattttctga gcaagcaaca caaaactcag      120

agacaaatta atattctcct tcctctcttc cttctactcc cccctctact cttgtaggcg      180

cgatcttcct cgaattttca gtcctggatc tcccgatacc tcttcttgtc aacttcggcc      240

cacaagaaca aatcacgggc tttcactctt gttgaggttg cgtggtgtcg ggggcgccat      300

tgaaacagag tcgataatgg cgaagccggc ccgtagccat tccaactctg ttacagaggt      360

cgaggcctgc gtttcgtcgc cagaagggag agggtccatc aggaaagatg ccagtcttcg      420

agaacggctg ctcagcaacc aaatcggaat ctcccttacc attcttacga tgatcttcgc      480

ggttcacaac ttataccctt cgcttagacc atacacgtct cctttcttaa ctttgccaca      540

ttaccgatcg acaaaaggaa tatacgtcca gggatgggac gacttgtact tcatcatcgg      600

ttccatggtc gcctttacag caatccgagc catcgcaatt gactggatcc ttatgcccat      660

cgcacaacaa cttgggctaa agttgaaggc atcgttgaga ttcgccgaac aaggctggct      720

actggtgtat tacattgtct tctggtccta tggtttgtat atttggatga attcaaagta      780

ctggatggat ttccgagaaa tttggacgga ctggccgtcg agagagatac caggctattt      840

caagctgtat tgcctgttgc agttgtcatt ttggttgcaa caaattttcg tcatcaacat      900

tgaggaaaga agaaaagacc attatcagat gttgacgcat catatcgtca caagcaccct      960

tctcggatca gcttatgttt acagcttcta taacgtggcc aacgttgttc tatgtattat     1020

ggatattgta gatttcctcc tcccggctgc gaagatgcta aaatatatgg gttacgagcg     1080

catttgcacc attgcattcg gggtcttcct agccacatgg ttcattgccc gccatgtgat     1140

ttacatgatg ttatggtggt ccatttacca aaatgttcca gatgcaatgt catttggatg     1200

ttatctgggc gcaaccggcc agaagcttat tgacgtatct cccgattcct ggggctcact     1260

catatatccg tttcgggata tcgatggacc tatttgcatg agtttccgca tcaaatgggc     1320

ctttctcact ctgctcctaa tacttcagat gctctctctt atctggttcg gcatgatcct     1380

tcgtgtggca gtgcatgtgc ttcggacagg ctcatccgcg gaggataccc gcagcgacga     1440

tgagggcgaa gaatcaactg aggcagtccg ccctgttcgc cgaggcagcc ctagaagaca     1500

ggaagattat gaagagaatg gatggagtaa atctgttgcg gtcaacggtt ccgcccagaa     1560

tcatcacccg gtgcgaatca gaacagctcg cggccgcgtt acactcagcg atcagaacga     1620

acgaaaggct ttactcggca gaatcgggtg cgacaagcct tcttaa                    1666


<210>  7
<211>  1080
<212>  DNA
<213>  Pichia kudriavzevii

<400>  7
atgagacaaa gatcggcatt ggaaaagcaa caaacaattg ttgacaagga tgaaaaaaat       60

tcaaaattta tcccgaaggg taacaaacgt gaacaaaggc aagagcaaaa gcgcctgtat      120

gaaatacatc agatccaaaa ttcagaatta gtcgataaag caattataat ttcatcactc      180

attttttatt taatcttatt cattgcatct cgatttgtgt ctctcaaatt caagaaattt      240

tacaagttgt catacaaata tgaagattct gattattatg acattggttt tgacgatctt      300

tattttggga tattttggat tatcaattta ctatttttaa ggagtttcct cattctattt      360

tgttttaatc catgcgcaaa actcttagga atcaaaaagt ttaaagccac ccaaagattt      420

attgaacagg cttggtcaat ggtatactac tcattttctt ggggattcgg gttctacctt      480

tactataatt ctgattatta tttagactgc tacaacattt atgccaattg gccacatgac      540

gtactctcag cacctatgaa attctactac ttgcttcaat cagcgagctg gttccaacaa      600

tttattgttc tacatataga gtcaaggaga aaggaccatt atcaaatgtt agcccaccat      660

atcatcactt gtattctaac aactgcttct tactcattat attttaccaa gattggtcat      720

gtgattcttt tattaatgga cattgtggat gtttttttgt caactgccaa aatcttaaaa      780

tatgctggat ttcaaacagt atgtgattta atgtttctat tttttatggt ttcttggatt      840

atatttagac atggagttta taattacgtt ttatggttta cagcaacaag ggctagagat      900

ataatgggaa ataagtgctc aacatttttg cctagtgaga cttataaagc atgttacaca      960

gatttacagg tggatatttt tatgctactc ctagttgcat tacaagtgat aatgtgtatc     1020

tggatgtata tgatttttag agtcgctttc catgttattt caggtggatc cgcagatgat     1080


<210>  8
<211>  1284
<212>  DNA
<213>  Candida albicans

<400>  8
atgagttcag gatcaattgc aactacaaca atacccagta caccaatgtc tattgaatca       60

atagaagatc atcaatatca taattctttt ttagccatgg ttgaaagaaa tcaaataccg      120

ttatctagaa atctattaat aattttatat ttatcacatt tattattaca aaataacaat      180

accactatta ctccttatac atccaaattt atacacattc aaaattgtgt tggtattgat      240

gaattcactg ggaaatcaat atatgatatt gatattaatg atacatattt tgtgattcat      300

tcattagtca ttgttacatt tcttcgttca ttcttgatga aatggtgttt tgaaccattt      360

gcatcgaaat tttgtcatat tcattcgaaa aaagccaaaa ctagatttgc tgaacaaagt      420

tggtcatttg tttattattc aatttcattt atatttggcg tggtattata ttgggatagt      480

ccttattata ataatttaga tcaagtttat atcaattggc caaatcatta catgtcatgg      540

gaatttaaaa cttattattt agtaagtatg ggattttggc tacaacaaat ttttgtttta      600

aatgttgaaa aaccaagaaa agatcattat caaatgttta gtcatcatat cattacttgt      660

ttattgatta ttggttcata ttattattat tatttccgta ttggtcattt aatattgatg      720

attatggatt cagtagacat ttttttggca gcagcaaaaa tgttaaaata cgctgggttt      780

agtaatgcat gtgatgccat gtttctttta tttttagtca gttggattgt attaagacat      840

ggagtatata attatatctt ttatcatgct tggtataaat cagttgattt aatgaaaaat      900

ggacaatgtg ttgaaggatt gatgcaaaaa agatgttgga ctccagttgt tattgataca      960

tttttgggtt tactcggagg attacaaatt ataacttgta tttggatgta tttgatatta     1020

aaagttgctt ataaagttgt tactggatca ggtgctgaag atgttcgaag tgatgaagat     1080

gacactgata ttgagttgga agaagaagaa aaagaagaag aagaggagga ggaagtagga     1140

caaccaatat ttgtggaaaa aaaggaagaa gaagttgtat tagaaattga agaagataaa     1200

tactcttttg aaagagattc atttagttca tcatcagaat caactttgga cgagaaaaag     1260

gatattagga aaagaaaagt ataa                                            1284


<210>  9
<211>  368
<212>  PRT
<213>  Cryptococcus neoformans

<400>  9

Met Ala Cys Asn Leu Thr Thr Ser Pro Leu Pro Ser Leu Leu His Ser 
1               5                   10                  15      


Tyr Val Pro Gln Ser Leu Arg Pro Phe Val Thr Leu Ser Tyr Pro Ile 
            20                  25                  30          


Thr Asp Pro Leu Ala His Pro Ser Ala Gln Thr Leu Tyr Asp Lys Gly 
        35                  40                  45              


Pro Gln Asp Ala Cys Leu Val Leu Phe Trp Ala Leu Ala Phe Thr Leu 
    50                  55                  60                  


Leu Arg Glu Ala Phe Met Lys Gly Val Phe Ser Pro Phe Met Arg Ile 
65                  70                  75                  80  


Cys Leu Pro Ser Pro Pro Gln Ile Lys Gly Gln Glu Arg Glu Tyr Ala 
                85                  90                  95      


Lys Ala Arg Lys Lys Arg Glu His Thr Val Thr Arg Phe Ala Glu Gln 
            100                 105                 110         


Gly Trp Ser Trp Leu Tyr Cys Ser Ile Tyr Trp Thr Phe Gly Val Ile 
        115                 120                 125             


Val Leu Arg Gln Asn Pro Ser Pro Thr Ser Pro Glu Gln Leu Trp Gly 
    130                 135                 140                 


Thr Tyr Pro Ala Val Pro Leu Pro Ala Leu Thr Lys Phe Tyr Tyr Leu 
145                 150                 155                 160 


Ser Gln Leu Gly Trp Trp Phe His Gln Leu Leu Val Ile Asn Cys Glu 
                165                 170                 175     


Lys Arg Arg Lys Asp His Trp Gln Met Phe Gly His His Ile Leu Thr 
            180                 185                 190         


Ile Thr Leu Val Val Gly Ser Tyr Val Met Asn Phe Thr Ser Val Gly 
        195                 200                 205             


Val Val Ile His Cys Leu Met Asp Phe Cys Asp Ile Leu Leu Pro Leu 
    210                 215                 220                 


Ala Lys Met Phe Arg Tyr Leu Ser Leu Ser Thr Leu Cys Asp Leu Thr 
225                 230                 235                 240 


Phe Val Val Phe Leu Ile Ser Trp Phe Ile Thr Arg Glu Ala Gly Leu 
                245                 250                 255     


Phe Leu Val Ile Arg Ser Thr Tyr Val Asp Ala Pro Lys Phe Ile Pro 
            260                 265                 270         


Phe Glu Trp Ala Pro Glu Gln Gly Arg Phe Leu Thr Tyr Arg Val Tyr 
        275                 280                 285             


Leu Gly Phe Val Ala Met Leu Ser Ile Leu Trp Ile Leu Ala Thr Ala 
    290                 295                 300                 


Trp Phe Tyr Met Ala Cys Asn Val Ala Ile Arg Val Val Arg Gly Met 
305                 310                 315                 320 


Gly Ala Glu Asp Ser Arg Ser Asp Asp Glu Ser Glu Glu Asp Ala Leu 
                325                 330                 335     


Glu Gln Val Pro Glu Ser Val Gly Ala Ser Thr Ala Thr Arg Ser Glu 
            340                 345                 350         


Val Glu Glu Asp Leu Arg Lys Arg Lys Leu Phe Ser Gln Arg Gly Thr 
        355                 360                 365             


<210>  10
<211>  443
<212>  PRT
<213>  Aspergillus fumigatus

<400>  10

Met Ala Lys Asp Glu Ser Thr Arg Ser Gln Ser Val Ser Glu Leu Asn 
1               5                   10                  15      


Thr Cys Val Ser Thr Ser His Arg Thr Ala Ala Lys Asp Ala Thr Phe 
            20                  25                  30          


Arg Glu Trp Met Asp Ala Asn Gln Ile Gly Val Ser Leu Thr Ile Leu 
        35                  40                  45              


Gly Thr Leu Leu Ala Ala His Asn Leu Tyr Pro Thr Leu Arg Pro Tyr 
    50                  55                  60                  


Thr Ala Pro Phe Phe Glu Leu Ser Tyr Tyr Gln Pro Ser Glu Gly Val 
65                  70                  75                  80  


Tyr Val Gln Gly Phe Asp Asp Val Tyr Phe Val Val Ser Ser Ala Ile 
                85                  90                  95      


Thr Phe Thr Ala Val Arg Ala Ile Ala Ile Glu Trp Ile Phe Arg Pro 
            100                 105                 110         


Ala Ala Arg Tyr Ala Gly Leu Lys Arg Lys Ala Ser Asn Arg Phe Ala 
        115                 120                 125             


Glu Gln Ala Trp Met Trp Met Tyr Tyr Ala Phe Phe Trp Thr Phe Gly 
    130                 135                 140                 


Met Tyr Ile Trp Thr Asn Ser Tyr Tyr Trp Met Asp Phe Lys Ala Ile 
145                 150                 155                 160 


Trp Ala Gln Trp Pro Ala Arg Gly Ile Ser Ala Asn Leu Lys Trp Tyr 
                165                 170                 175     


Leu Leu Ala Gln Leu Ser Phe Trp Phe Gln Gln Ile Leu Val Ile Asn 
            180                 185                 190         


Met Glu Glu Arg Arg Lys Asp His Tyr Gln Met Leu Thr His His Ile 
        195                 200                 205             


Ile Thr Ser Thr Leu Leu Thr Ser Ala Tyr Ile Tyr Gly Phe Tyr Asn 
    210                 215                 220                 


Val Ser Asn Val Val Leu Cys Leu Met Asp Ile Val Asp Leu Leu Leu 
225                 230                 235                 240 


Pro Thr Ala Lys Ile Leu Lys Tyr Phe Lys Phe Glu Leu Cys Cys Asn 
                245                 250                 255     


Ile Thr Phe Gly Leu Phe Met Val Thr Trp Leu Ile Thr Arg His Ile 
            260                 265                 270         


Phe Tyr Pro Leu Leu Cys Trp Ser Ile Tyr Lys Asp Val Pro Asp Ala 
        275                 280                 285             


Met Ala Tyr Gly Cys Tyr Ser Gly Ser Thr Ala Glu Met Ile Ser Thr 
    290                 295                 300                 


Asp Gly Tyr Pro Asn Arg Phe Arg Tyr Leu Phe Asn Pro Phe Leu Asp 
305                 310                 315                 320 


Ile Asn Gly Pro Ile Cys Met Asn Arg Thr Val Lys Trp Ile Phe Leu 
                325                 330                 335     


Gly Phe Leu Leu Ala Leu Gln Leu Leu Ser Leu Ile Trp Phe Val Met 
            340                 345                 350         


Val Val Arg Val Ala Val Asn Val Leu Arg Thr Gly Asn Ala Glu Asp 
        355                 360                 365             


Thr Arg Ser Asp Gly Glu Glu Glu Glu Glu Glu Val Glu Val Arg Pro 
    370                 375                 380                 


Val Gly Lys Asp Ala Leu Asn Asn Asn Pro Val Gly Val Asp Gly Ala 
385                 390                 395                 400 


Asn Ala Asp Trp Arg Arg Ala Ser Ser Gly Ser Ala Ser Val Arg Pro 
                405                 410                 415     


Arg Ala Arg Gly Arg Ile Pro Leu Gly Asp Gln Ser Asp Arg Lys Ala 
            420                 425                 430         


Leu Leu Gly Arg Ile Gly Cys Asp Lys Pro Thr 
        435                 440             


<210>  11
<211>  371
<212>  PRT
<213>  Candida auris

<400>  11

Met Lys Leu Thr Ala Ser Gln Arg Gln Lys Leu Asn Gln Arg Val Arg 
1               5                   10                  15      


Ala Leu Ser Asp Glu Ser Arg Thr Asp Val Ala Ile Ile Arg Lys Met 
            20                  25                  30          


Phe Val Ala Phe Lys Glu Leu Ser Phe Arg His Thr Trp Ile Asn Pro 
        35                  40                  45              


Phe Ile Ile Leu Ser Val Phe Tyr Ile Ser Tyr Phe Gly Thr Thr Glu 
    50                  55                  60                  


Ser Asn Pro Ile His Glu Asn Leu Lys Lys Leu Ile Lys Pro Ser Tyr 
65                  70                  75                  80  


His Ile Val Gly Thr Asp Gln Tyr Gly Lys Gly Val Asn Asp Phe Tyr 
                85                  90                  95      


Phe Val Ala Phe Tyr Ala Leu Phe Phe Thr Phe Leu Arg Glu Phe Met 
            100                 105                 110         


Met Cys Val Ile Leu Arg Pro Leu Ala Gly Met Leu Gly Val Thr Arg 
        115                 120                 125             


Pro His Lys Val Asn Arg Phe Met Glu Gln Ser Tyr Ala Met Phe Tyr 
    130                 135                 140                 


Tyr Gly Leu Ser Gly Pro Tyr Gly Leu Tyr Val Met Ser Arg Met Pro 
145                 150                 155                 160 


Leu Trp Phe Phe Glu Thr Thr Pro Leu Tyr Glu Ser Tyr Pro His Lys 
                165                 170                 175     


Thr His Trp Leu Phe Lys Val Tyr Tyr Leu Gly Gln Ala Ala Phe Trp 
            180                 185                 190         


Val Gln Gln Ser Val Val Leu Ile Leu Gln Leu Glu Lys Pro Arg Lys 
        195                 200                 205             


Asp Phe His Glu Leu Ile Leu His His Ile Ile Thr Ile Ala Leu Ile 
    210                 215                 220                 


Trp Leu Ser Tyr Arg Phe His Phe Thr Trp Met Gly Leu Glu Ile Tyr 
225                 230                 235                 240 


Val Thr Met Asp Val Ser Asp Phe Phe Leu Ala Thr Ser Lys Thr Leu 
                245                 250                 255     


Asn Tyr Leu Asp Ser Ile Leu Thr Gly Pro Phe Leu Ile Gly Phe Val 
            260                 265                 270         


Phe Ile Trp Ile Tyr Leu Arg His Tyr Val Asn Leu Lys Ile Leu Trp 
        275                 280                 285             


Ser Val Leu Thr Glu Phe Lys Thr Val Gly Glu Trp Glu Leu Asn Trp 
    290                 295                 300                 


Glu Thr Gln Gln Tyr Lys Cys Trp Ile Ser Gln Pro Ile Val Phe Gly 
305                 310                 315                 320 


Leu Ile Phe Ala Leu Gln Val Leu Asn Ala Tyr Trp Leu Phe Leu Ile 
                325                 330                 335     


Leu Arg Ile Leu Tyr Arg Tyr Val Val Gly Gly Val Lys Ala Asp Glu 
            340                 345                 350         


Arg Ser Glu Ser Glu Asp Glu Asp Glu Asp Glu Pro Pro Gln Lys Asp 
        355                 360                 365             


Lys Ser Val 
    370     


<210>  12
<211>  472
<212>  PRT
<213>  Balstomyces dermatitidis

<400>  12

Met Val Lys Thr Leu Ser Ser Gln Pro Asn Ser Val Ser Glu Val Asn 
1               5                   10                  15      


Ala Cys Val Ser Pro Met Glu Gly Cys Arg Ala Ala Lys Met Lys Pro 
            20                  25                  30          


Lys Glu Glu Thr Asn Phe Arg Gln Trp Val Leu Gln Asn Gln Ile Gly 
        35                  40                  45              


Ile Cys Ile Thr Ile Leu Thr Met Ile Phe Ala Leu His Asn Leu Tyr 
    50                  55                  60                  


Pro Ser Leu Arg Pro Tyr Thr Ser Pro Phe Leu Gln Leu Pro His Tyr 
65                  70                  75                  80  


Gln Pro Glu Lys Gly Thr Tyr Val Gln Gly Trp Asp Asp Leu Tyr Phe 
                85                  90                  95      


Ala Met Gly Gly Val Leu Ala Phe Thr Ala Val Arg Ala Ile Ala Val 
            100                 105                 110         


Glu Trp Ile Phe Gln Pro Leu Ala Arg Arg Tyr Gly Leu Lys His Lys 
        115                 120                 125             


Ala Ala Val Arg Leu Ala Glu Gln Gly Trp Leu Leu Val Tyr Tyr Phe 
    130                 135                 140                 


Gly Phe Trp Thr Tyr Gly Val Cys Leu Trp Tyr His Ser Lys Tyr Trp 
145                 150                 155                 160 


Asn Asn Phe Arg Glu Ile Trp Thr Asp Trp Pro Ser Arg Asp Ile Ser 
                165                 170                 175     


Gly Val Phe Lys Trp Tyr Cys Leu Thr Gln Leu Ala Phe Trp Phe Gln 
            180                 185                 190         


Gln Ile Ile Val Ile Asn Ile Glu Glu Arg Arg Lys Asp Tyr Tyr Gln 
        195                 200                 205             


Met Leu Val His His Ile Val Thr Ser Thr Leu Leu Gly Ser Ala Tyr 
    210                 215                 220                 


Val Tyr Gly Phe Tyr Asn Val Ala Asn Val Val Leu Cys Ile Met Asp 
225                 230                 235                 240 


Ile Val Asp Phe Leu Leu Pro Ala Ala Lys Ile Leu Lys Tyr Leu Gly 
                245                 250                 255     


Tyr Glu Arg Ala Cys Thr Val Gly Phe Ile Val Phe Leu Val Thr Trp 
            260                 265                 270         


Val Ile Ser Arg His Ile Ile Tyr Asn Leu Leu Trp Trp Ser Ile Tyr 
        275                 280                 285             


Val Asn Val Pro Asp Val Met Pro Tyr Gly Cys Tyr Ser Ala Thr Thr 
    290                 295                 300                 


Thr Lys Met Ile Ser Pro Ala Ala Asn Thr Thr Leu Asp Asn Gly Ala 
305                 310                 315                 320 


Ala Ser Ile Asp Leu Asn Asn Trp Asn His Leu Leu His Pro Phe Gln 
                325                 330                 335     


Asp Leu Gly Gly Arg Ile Cys Met Ser Pro Arg Ile Lys Trp Val Phe 
            340                 345                 350         


Leu Ser Phe Leu Leu Phe Leu Gln Ile Leu Ala Leu Ile Trp Phe Thr 
        355                 360                 365             


Met Ile Leu Arg Val Ala Val Lys Val Leu Lys Ser Gly Ser Ala Glu 
    370                 375                 380                 


Asp Ser Arg Ser Asp Asp Glu Gly Glu Glu Glu Glu Glu Val Asn Ser 
385                 390                 395                 400 


Glu Thr Thr Arg Met Gly Gly Asn Gly Thr Ile Ala Gly Val Arg Asp 
                405                 410                 415     


Gly Ile Asn Gly Asn Gly Thr Ala Ile Val Ser Gly Ser Ser Thr Ser 
            420                 425                 430         


Ser Ser Thr Ala Gln Gly His His Pro Val Arg Ile Arg Thr Gly Arg 
        435                 440                 445             


Gly Arg Val Thr Leu Ser Asp Gln Asn Asp Arg Lys Ala Leu Leu Gly 
    450                 455                 460                 


Arg Ile Gly Cys Asp Lys Pro Ser 
465                 470         


<210>  13
<211>  442
<212>  PRT
<213>  Histoplasma capsulatum

<400>  13

Met Thr Lys Val Lys Pro Thr Pro Glu Thr Asn Phe Arg Gln Trp Val 
1               5                   10                  15      


Leu Gln Asn Gln Ile Gly Ile Cys Ile Thr Thr Leu Thr Met Ile Phe 
            20                  25                  30          


Ala Leu His Asn Leu Tyr Pro Ser Leu Arg Pro Tyr Thr Ser Pro Phe 
        35                  40                  45              


Leu Gln Leu Pro His Tyr Gln Pro Glu Lys Gly Thr Tyr Val Gln Gly 
    50                  55                  60                  


Trp Asp Asp Ile Tyr Phe Val Met Gly Gly Val Leu Ala Phe Thr Ala 
65                  70                  75                  80  


Val Arg Ala Ile Ala Ile Glu Trp Ile Phe Gln Pro Leu Ala Arg Arg 
                85                  90                  95      


Tyr Gly Leu Lys His Lys Ala Ser Val Arg Leu Ala Glu Gln Gly Trp 
            100                 105                 110         


Ile Leu Val Tyr Tyr Phe Gly Phe Trp Ala Tyr Gly Val Phe Leu Trp 
        115                 120                 125             


Tyr Asn Ser Lys Tyr Trp Tyr Asn Phe Arg Glu Ile Trp Thr Asp Trp 
    130                 135                 140                 


Pro Ser Arg Asp Ile Ser Gly Ile Phe Lys Trp Tyr Cys Leu Thr Gln 
145                 150                 155                 160 


Leu Ala Phe Trp Phe Gln Gln Ile Leu Val Ile Asn Ile Glu Glu Arg 
                165                 170                 175     


Arg Lys Asp Tyr Cys Gln Met Leu Val His His Ile Val Thr Ser Thr 
            180                 185                 190         


Leu Leu Gly Ser Ala Tyr Val Tyr Gly Phe Tyr Asn Val Ala Asn Val 
        195                 200                 205             


Val Leu Cys Ile Met Asp Ile Val Asp Phe Leu Leu Pro Ala Ala Lys 
    210                 215                 220                 


Ile Leu Lys Tyr Leu Gly Tyr Glu Arg Ala Cys Thr Ala Gly Phe Ile 
225                 230                 235                 240 


Val Phe Leu Val Thr Trp Val Ile Ser Arg His Ile Val Tyr Asn Leu 
                245                 250                 255     


Leu Trp Trp Ser Ile Tyr Ile Asn Val Pro Asp Val Met Pro Tyr Gly 
            260                 265                 270         


Cys Tyr Ser Ala Thr Thr Thr Glu Met Ile Ser Pro Ala Ala Asn Ala 
        275                 280                 285             


Thr Leu Asp Gly Ala Ala Ser Ile Asp Leu Asn Asn Trp Ser His Leu 
    290                 295                 300                 


Leu Gln Pro Phe Arg Asp Leu Gly Gly Arg Ile Cys Met Ser Pro Arg 
305                 310                 315                 320 


Val Lys Trp Val Phe Leu Ser Phe Leu Leu Phe Leu Gln Ile Leu Ala 
                325                 330                 335     


Ile Leu Trp Phe Thr Met Ile Leu Arg Val Ala Val Lys Val Leu Lys 
            340                 345                 350         


Ser Gly Ser Ala Glu Asp Ser Arg Ser Asp Asp Glu Glu Glu Asp Glu 
        355                 360                 365             


Glu Glu Val Asp Ser Gln Asn Leu Arg Thr Glu Gly Asn Ala Gly Val 
    370                 375                 380                 


Arg Asp Gly Gly Arg Gly Asn Gly Thr Ala Ile Val Ser Gly Ser Ser 
385                 390                 395                 400 


Val Ser Ser Ser Ala Gly Gln Gly His His Pro Val Arg Ile Arg Thr 
                405                 410                 415     


Gly Arg Gly Arg Val Thr Leu Ser Asp Gln Asn Asp Arg Lys Ala Leu 
            420                 425                 430         


Leu Gly Arg Ile Gly Cys Asp Lys Pro Thr 
        435                 440         


<210>  14
<211>  449
<212>  PRT
<213>  Coccidioides immitis

<400>  14

Met Ala Lys Pro Ala Arg Ser His Ser Asn Ser Val Thr Glu Val Glu 
1               5                   10                  15      


Ala Cys Val Ser Ser Pro Glu Gly Arg Gly Ser Ile Arg Lys Asp Ala 
            20                  25                  30          


Ser Leu Arg Glu Arg Leu Leu Ser Asn Gln Ile Gly Ile Ser Leu Thr 
        35                  40                  45              


Ile Leu Thr Met Ile Phe Ala Val His Asn Leu Tyr Pro Ser Leu Arg 
    50                  55                  60                  


Pro Tyr Thr Ser Pro Phe Leu Thr Leu Pro His Tyr Arg Ser Thr Lys 
65                  70                  75                  80  


Gly Ile Tyr Val Gln Gly Trp Asp Asp Leu Tyr Phe Ile Ile Gly Ser 
                85                  90                  95      


Met Val Ala Phe Thr Ala Ile Arg Ala Ile Ala Ile Asp Trp Ile Leu 
            100                 105                 110         


Met Pro Ile Ala Gln Gln Leu Gly Leu Lys Leu Lys Ala Ser Leu Arg 
        115                 120                 125             


Phe Ala Glu Gln Gly Trp Leu Leu Val Tyr Tyr Ile Val Phe Trp Ser 
    130                 135                 140                 


Tyr Gly Leu Tyr Ile Trp Met Asn Ser Lys Tyr Trp Met Asp Phe Arg 
145                 150                 155                 160 


Glu Ile Trp Thr Asp Trp Pro Ser Arg Glu Ile Pro Gly Tyr Phe Lys 
                165                 170                 175     


Leu Tyr Cys Leu Leu Gln Leu Ser Phe Trp Leu Gln Gln Ile Phe Val 
            180                 185                 190         


Ile Asn Ile Glu Glu Arg Arg Lys Asp His Tyr Gln Met Leu Thr His 
        195                 200                 205             


His Ile Val Thr Ser Thr Leu Leu Gly Ser Ala Tyr Val Tyr Ser Phe 
    210                 215                 220                 


Tyr Asn Val Ala Asn Val Val Leu Cys Ile Met Asp Ile Val Asp Phe 
225                 230                 235                 240 


Leu Leu Pro Ala Ala Lys Met Leu Lys Tyr Met Gly Tyr Glu Arg Ile 
                245                 250                 255     


Cys Thr Ile Ala Phe Gly Val Phe Leu Ala Thr Trp Phe Ile Ala Arg 
            260                 265                 270         


His Val Ile Tyr Met Met Leu Trp Trp Ser Ile Tyr Gln Asn Val Pro 
        275                 280                 285             


Asp Ala Met Ser Phe Gly Cys Tyr Leu Gly Ala Thr Gly Gln Lys Leu 
    290                 295                 300                 


Ile Asp Val Ser Pro Asp Ser Trp Gly Ser Leu Ile Tyr Pro Phe Arg 
305                 310                 315                 320 


Asp Ile Asp Gly Pro Ile Cys Met Ser Phe Arg Ile Lys Trp Ala Phe 
                325                 330                 335     


Leu Thr Leu Leu Leu Ile Leu Gln Met Leu Ser Leu Ile Trp Phe Gly 
            340                 345                 350         


Met Ile Leu Arg Val Ala Val His Val Leu Arg Thr Gly Ser Ser Ala 
        355                 360                 365             


Glu Asp Thr Arg Ser Asp Asp Glu Gly Glu Glu Ser Thr Glu Ala Val 
    370                 375                 380                 


Arg Pro Val Arg Arg Gly Ser Pro Arg Arg Gln Glu Asp Tyr Glu Glu 
385                 390                 395                 400 


Asn Gly Trp Ser Lys Ser Val Ala Val Asn Gly Ser Ala Gln Asn His 
                405                 410                 415     


His Pro Val Arg Ile Arg Thr Ala Arg Gly Arg Val Thr Leu Ser Asp 
            420                 425                 430         


Gln Asn Glu Arg Lys Ala Leu Leu Gly Arg Ile Gly Cys Asp Lys Pro 
        435                 440                 445             


Ser 
    


<210>  15
<211>  367
<212>  PRT
<213>  Pichia kudriavzevii

<400>  15

Met Arg Gln Arg Ser Ala Leu Glu Lys Gln Gln Thr Ile Val Asp Lys 
1               5                   10                  15      


Asp Glu Lys Asn Ser Lys Phe Ile Pro Lys Gly Asn Lys Arg Glu Gln 
            20                  25                  30          


Arg Gln Glu Gln Lys Arg Leu Tyr Glu Ile His Gln Ile Gln Asn Ser 
        35                  40                  45              


Glu Leu Val Asp Lys Ala Ile Ile Ile Ser Ser Leu Ile Phe Tyr Leu 
    50                  55                  60                  


Ile Leu Phe Ile Ala Ser Arg Phe Val Ser Leu Lys Phe Lys Lys Phe 
65                  70                  75                  80  


Tyr Lys Leu Ser Tyr Lys Tyr Glu Asp Ser Asp Tyr Tyr Asp Ile Gly 
                85                  90                  95      


Phe Asp Asp Leu Tyr Phe Gly Ile Phe Trp Ile Ile Asn Leu Leu Phe 
            100                 105                 110         


Leu Arg Ser Phe Leu Ile Leu Phe Cys Phe Asn Pro Cys Ala Lys Leu 
        115                 120                 125             


Leu Gly Ile Lys Lys Phe Lys Ala Thr Gln Arg Phe Ile Glu Gln Ala 
    130                 135                 140                 


Trp Ser Met Val Tyr Tyr Ser Phe Ser Trp Gly Phe Gly Phe Tyr Leu 
145                 150                 155                 160 


Tyr Tyr Asn Ser Asp Tyr Tyr Leu Asp Cys Tyr Asn Ile Tyr Ala Asn 
                165                 170                 175     


Trp Pro His Asp Val Leu Ser Ala Pro Met Lys Phe Tyr Tyr Leu Leu 
            180                 185                 190         


Gln Ser Ala Ser Trp Phe Gln Gln Phe Ile Val Leu His Ile Glu Ser 
        195                 200                 205             


Arg Arg Lys Asp His Tyr Gln Met Leu Ala His His Ile Ile Thr Cys 
    210                 215                 220                 


Ile Leu Thr Thr Ala Ser Tyr Ser Leu Tyr Phe Thr Lys Ile Gly His 
225                 230                 235                 240 


Val Ile Leu Leu Leu Met Asp Ile Val Asp Val Phe Leu Ser Thr Ala 
                245                 250                 255     


Lys Ile Leu Lys Tyr Ala Gly Phe Gln Thr Val Cys Asp Leu Met Phe 
            260                 265                 270         


Leu Phe Phe Met Val Ser Trp Ile Ile Phe Arg His Gly Val Tyr Asn 
        275                 280                 285             


Tyr Val Leu Trp Phe Thr Ala Thr Arg Ala Arg Asp Ile Met Gly Asn 
    290                 295                 300                 


Lys Cys Ser Thr Phe Leu Pro Ser Glu Thr Tyr Lys Ala Cys Tyr Thr 
305                 310                 315                 320 


Asp Leu Gln Val Asp Ile Phe Met Leu Leu Leu Val Ala Leu Gln Val 
                325                 330                 335     


Ile Met Cys Ile Trp Met Tyr Met Ile Phe Arg Val Ala Phe His Val 
            340                 345                 350         


Ile Ser Gly Gly Ser Ala Asp Asp Val Arg Ser Asp Thr Asp Asp 
        355                 360                 365         


<210>  16
<211>  427
<212>  PRT
<213>  Candida albicans

<400>  16

Met Ser Ser Gly Ser Ile Ala Thr Thr Thr Ile Pro Ser Thr Pro Met 
1               5                   10                  15      


Ser Ile Glu Ser Ile Glu Asp His Gln Tyr His Asn Ser Phe Leu Ala 
            20                  25                  30          


Met Val Glu Arg Asn Gln Ile Pro Leu Ser Arg Asn Leu Leu Ile Ile 
        35                  40                  45              


Leu Tyr Leu Ser His Leu Leu Leu Gln Asn Asn Asn Thr Thr Ile Thr 
    50                  55                  60                  


Pro Tyr Thr Ser Lys Phe Ile His Ile Gln Asn Cys Val Gly Ile Asp 
65                  70                  75                  80  


Glu Phe Thr Gly Lys Ser Ile Tyr Asp Ile Asp Ile Asn Asp Thr Tyr 
                85                  90                  95      


Phe Val Ile His Ser Leu Val Ile Val Thr Phe Leu Arg Ser Phe Leu 
            100                 105                 110         


Met Lys Trp Cys Phe Glu Pro Phe Ala Ser Lys Phe Cys His Ile His 
        115                 120                 125             


Ser Lys Lys Ala Lys Thr Arg Phe Ala Glu Gln Ser Trp Ser Phe Val 
    130                 135                 140                 


Tyr Tyr Ser Ile Ser Phe Ile Phe Gly Val Val Leu Tyr Trp Asp Ser 
145                 150                 155                 160 


Pro Tyr Tyr Asn Asn Leu Asp Gln Val Tyr Ile Asn Trp Pro Asn His 
                165                 170                 175     


Tyr Met Ser Trp Glu Phe Lys Thr Tyr Tyr Leu Val Ser Met Gly Phe 
            180                 185                 190         


Trp Leu Gln Gln Ile Phe Val Leu Asn Val Glu Lys Pro Arg Lys Asp 
        195                 200                 205             


His Tyr Gln Met Phe Ser His His Ile Ile Thr Cys Leu Leu Ile Ile 
    210                 215                 220                 


Gly Ser Tyr Tyr Tyr Tyr Tyr Phe Arg Ile Gly His Leu Ile Leu Met 
225                 230                 235                 240 


Ile Met Asp Ser Val Asp Ile Phe Leu Ala Ala Ala Lys Met Leu Lys 
                245                 250                 255     


Tyr Ala Gly Phe Ser Asn Ala Cys Asp Ala Met Phe Leu Leu Phe Leu 
            260                 265                 270         


Val Ser Trp Ile Val Leu Arg His Gly Val Tyr Asn Tyr Ile Phe Tyr 
        275                 280                 285             


His Ala Trp Tyr Lys Ser Val Asp Leu Met Lys Asn Gly Gln Cys Val 
    290                 295                 300                 


Glu Gly Leu Met Gln Lys Arg Cys Trp Thr Pro Val Val Ile Asp Thr 
305                 310                 315                 320 


Phe Leu Gly Leu Leu Gly Gly Leu Gln Ile Ile Thr Cys Ile Trp Met 
                325                 330                 335     


Tyr Leu Ile Leu Lys Val Ala Tyr Lys Val Val Thr Gly Ser Gly Ala 
            340                 345                 350         


Glu Asp Val Arg Ser Asp Glu Asp Asp Thr Asp Ile Glu Leu Glu Glu 
        355                 360                 365             


Glu Glu Lys Glu Glu Glu Glu Glu Glu Glu Val Gly Gln Pro Ile Phe 
    370                 375                 380                 


Val Glu Lys Lys Glu Glu Glu Val Val Leu Glu Ile Glu Glu Asp Lys 
385                 390                 395                 400 


Tyr Ser Phe Glu Arg Asp Ser Phe Ser Ser Ser Ser Glu Ser Thr Leu 
                405                 410                 415     


Asp Glu Lys Lys Asp Ile Arg Lys Arg Lys Val 
            420                 425         


