                         SEQUENCE LISTING

<110>  The National Institute for Biotechnology in the Negev, at 
       Ben-Gurion University
 
<120>  ANGIOPOIETIN 2-BASED POLYPEPTIDE INHIBITORS AND METHODS OF USE 
       THEREOF

<130>  3145/4.2

<150>  US 62/475,378
<151>  2017-03-23

<150>  US 62/550,709
<151>  2017-08-28

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is N or D

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  X is D or N

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  X is K or E

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X is Y or F

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  X is L or S

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  X is H or R

<220>
<221>  MISC_FEATURE
<222>  (128)..(128)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (134)..(134)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (153)..(153)
<223>  X is K or N

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (188)..(188)
<223>  X is N or K

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  X is F or L

<220>
<221>  MISC_FEATURE
<222>  (191)..(191)
<223>  X is N or D

<220>
<221>  MISC_FEATURE
<222>  (196)..(196)
<223>  X is Y or H

<400>  1

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Xaa Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Xaa Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Xaa 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Xaa Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Xaa Tyr Glu Xaa Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Xaa 
        115                 120                 125             


Gly Thr Ala Gly Lys Xaa Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Xaa Cys Xaa Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Xaa Lys Xaa Xaa Gly 
            180                 185                 190         


Ile Lys Trp Xaa Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  2
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  3
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  3

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Ser Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Leu Asn Gly 
            180                 185                 190         


Ile Lys Trp His Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  4
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  4

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Lys Lys Phe Asn Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  5
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  5

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Phe Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Ala 
        115                 120                 125             


Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  6
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  6

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asp Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asn Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Glu 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu Arg Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  7
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  7

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  8
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is F, L or S

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  X is F or L

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  X is S or L

<220>
<221>  MISC_FEATURE
<222>  (123)..(123)
<223>  X is H or R

<220>
<221>  MISC_FEATURE
<222>  (142)..(142)
<223>  X is N or Y

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  X is N or Y

<220>
<221>  MISC_FEATURE
<222>  (188)..(188)
<223>  X is N, Y, H or K

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  X is F or L

<400>  8

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Xaa Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Xaa Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Xaa 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Xaa Ser Glu Glu Leu Asn Tyr Arg Ile Xaa Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Xaa Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Xaa Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Xaa Lys Xaa Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  9
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  9

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Tyr Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  10
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  10

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Tyr Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  11
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  11

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr His Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  12
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  12

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Leu Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Tyr Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  13
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  13

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile Arg Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Tyr Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  14
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  14

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Leu 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Tyr Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  15
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  15

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Arg Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Lys Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  16
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  16

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Thr Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Tyr Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  17
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  17

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Leu Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Lys Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  18
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  18

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Tyr Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Leu Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  19
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  19

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Ser Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Tyr Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  20
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  20

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Lys Lys Phe Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  21
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  21

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Thr Phe Pro Asn Ser Thr Glu Glu Ile Lys Ala 
            20                  25                  30          


Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln Arg 
        35                  40                  45              


Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr Lys 
    50                  55                  60                  


Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu Phe 
65                  70                  75                  80  


Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His Leu 
                85                  90                  95      


Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe Tyr 
            100                 105                 110         


Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu Thr 
        115                 120                 125             


Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Asn Asp Phe 
    130                 135                 140                 


Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser Gln 
145                 150                 155                 160 


Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn Leu 
                165                 170                 175     


Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Leu Asp Gly 
            180                 185                 190         


Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala Thr 
        195                 200                 205             


Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215         


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  22

Leu Pro Asp Lys Pro Leu Ala Phe Gln Asp Pro Ser 
1               5                   10          


<210>  23
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is N, R, Y, or G

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is T, E, P, or R

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is C, G, R, or P

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X is C, N, or M

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  X is L, V, or P

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is P, D, or S

<400>  23

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Xaa Xaa Xaa Arg Gly Asp Xaa Xaa Xaa Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215             


<210>  24
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  24

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Asn Thr Cys Arg Gly Asp Cys Leu Pro Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215             


<210>  25
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  25

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Arg Glu Gly Arg Gly Asp Asn Val Asp Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215             


<210>  26
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  26

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Tyr Pro Gly Arg Gly Asp Asn Pro Asp Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215             


<210>  27
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  27

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Gly Arg Arg Arg Gly Asp Met Pro Asp Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215             


<210>  28
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  28

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Tyr Glu Pro Arg Gly Asp Asn Pro Ser Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Ile Ser Ser Ile Ser Gln Pro Gly Asn Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Lys Cys Ile Cys Lys Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Phe Asn 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215             


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  29

Val Thr Gly Arg Gly Asp Ser Pro Ala 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  30

Gln Val Thr Arg Gly Asp Val Phe Thr 
1               5                   


<210>  31
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X is N, R, Y, or G

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is N, R, Y, or G

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X is C, G, R, or P

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X is C, N, or M

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  X is L, V, or P

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is P, D, or S

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  X is F or L

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  X is S or L

<220>
<221>  MISC_FEATURE
<222>  (124)..(124)
<223>  X is H or R

<220>
<221>  MISC_FEATURE
<222>  (143)..(143)
<223>  X is N or Y

<220>
<221>  MISC_FEATURE
<222>  (158)..(158)
<223>  X is K or R

<220>
<221>  MISC_FEATURE
<222>  (189)..(189)
<223>  X is N, Y, H or K

<220>
<221>  MISC_FEATURE
<222>  (191)..(191)
<223>  X is F or L

<400>  31

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Xaa Xaa Xaa Arg Gly Asp Xaa Xaa Xaa Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Xaa Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Xaa Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Xaa Ser Glu Glu Leu Asn Tyr Arg Ile Xaa Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Xaa Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Xaa Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Xaa Lys Xaa Asp 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe 
    210                 215             


<210>  32
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  32

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Asn Thr Cys Arg Gly Asp Cys Leu Pro Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Tyr Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Leu Asp 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe Pro Arg 
    210                 215                 220 


<210>  33
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  33

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Arg Glu Gly Arg Gly Asp Asn Val Asp Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Tyr Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Leu Asp 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe Pro Arg 
    210                 215                 220 


<210>  34
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  34

Glu Phe Arg Asp Cys Ala Glu Val Phe Lys Ser Gly His Thr Thr Asn 
1               5                   10                  15      


Gly Ile Tyr Thr Leu Tyr Pro Gly Arg Gly Asp Asn Pro Asp Ile Lys 
            20                  25                  30          


Ala Tyr Cys Asp Met Glu Ala Gly Gly Gly Gly Trp Thr Ile Ile Gln 
        35                  40                  45              


Arg Arg Glu Asp Gly Ser Val Asp Phe Gln Arg Thr Trp Lys Glu Tyr 
    50                  55                  60                  


Lys Val Gly Phe Gly Asn Pro Ser Gly Glu Tyr Trp Leu Gly Asn Glu 
65                  70                  75                  80  


Phe Val Ser Gln Leu Thr Asn Gln Gln Arg Tyr Val Leu Lys Ile His 
                85                  90                  95      


Leu Lys Asp Trp Glu Gly Asn Glu Ala Tyr Ser Leu Tyr Glu His Phe 
            100                 105                 110         


Tyr Leu Ser Ser Glu Glu Leu Asn Tyr Arg Ile His Leu Lys Gly Leu 
        115                 120                 125             


Thr Gly Thr Ala Gly Lys Thr Ser Ser Ile Ser Gln Pro Gly Tyr Asp 
    130                 135                 140                 


Phe Ser Thr Lys Asp Gly Asp Asn Asp Asn Cys Thr Cys Lys Cys Ser 
145                 150                 155                 160 


Gln Met Leu Thr Gly Gly Trp Trp Phe Asp Ala Cys Gly Pro Ser Asn 
                165                 170                 175     


Leu Asn Gly Met Tyr Tyr Pro Gln Arg Gln Asn Thr Asn Lys Leu Asp 
            180                 185                 190         


Gly Ile Lys Trp Tyr Tyr Trp Lys Gly Ser Gly Tyr Ser Leu Lys Ala 
        195                 200                 205             


Thr Thr Met Met Ile Arg Pro Ala Asp Phe Pro Arg 
    210                 215                 220 


