                         SEQUENCE LISTING

<110>  Horizon Discovery Limited
 
<120>  ARGONAUTE SYSTEM

<130>  P9114WO1

<160>  156   

<170>  PatentIn version 3.5

<210>  1
<211>  710
<212>  PRT
<213>  Bacillus sp. (strain JF8)


<220>
<221>  misc_feature
<223>  UniProt ID No: S5Z517

<400>  1

Met Asn His Tyr Tyr Phe Ser Glu Cys Lys Ala Asn Glu Lys Ala Ser 
1               5                   10                  15      


Asp Ile Ala Ile His Leu Tyr Thr Ile Pro Leu Ser Asn Pro His Glu 
            20                  25                  30          


Lys Tyr Ser Tyr Ala His Ser Ile Ala Tyr Glu Leu Arg Lys Leu Asn 
        35                  40                  45              


Ser Tyr Ile Thr Val Thr Ala His Gly Gln Tyr Ile Ala Ser Phe Glu 
    50                  55                  60                  


Glu Ile Cys His Trp Arg Asp His Arg Tyr Ile Gln His Glu Tyr Arg 
65                  70                  75                  80  


Pro Ile Gln Cys Ser Leu Pro Met Glu Arg Thr Ile Leu Glu Arg Leu 
                85                  90                  95      


Leu Lys Lys Glu Leu Glu Asn Arg Cys Lys Ser Ser Tyr Lys Met Asp 
            100                 105                 110         


Asn Asp Leu Phe Arg Leu Ala Asn Gly Gln Ser Met His Val Gly Glu 
        115                 120                 125             


Ile Ser Val His Pro Ala Ile Tyr Ile Ser Phe Ser Val Glu Glu Asn 
    130                 135                 140                 


Gly Asp Ile Phe Val Gly Phe Asp Tyr Gln His Arg Phe Glu Tyr Arg 
145                 150                 155                 160 


Lys Thr Leu Gln Asp Val Ile Asn Asn Asp Pro Ser Ile Leu Lys Glu 
                165                 170                 175     


Gly Met Glu Val Val Asp Pro Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr 
            180                 185                 190         


Phe Val Gly Met Ala Asp Tyr Thr Ala Gly Gln Lys Ser Pro Phe Leu 
        195                 200                 205             


Gln Gln Ser Val Ile Asp Tyr Tyr Leu Glu Lys Asn Glu Leu Trp Lys 
    210                 215                 220                 


Leu Lys Gly Val His Glu Lys Thr Pro Val Val His Val Lys Asn Arg 
225                 230                 235                 240 


Asp Gly His Leu Leu Pro Tyr Leu Pro His Leu Leu Lys Leu Thr Cys 
                245                 250                 255     


Ser Tyr Glu Gln Leu Pro Pro Ser Met Thr Lys Lys Val Asn Arg Leu 
            260                 265                 270         


Ile Lys Leu Ser Pro His Glu Lys Met Phe Lys Leu Tyr Thr Glu Ala 
        275                 280                 285             


Phe Arg Leu Leu Ser Gln Gln Gln Val Leu Thr Phe Gln Lys Glu Asn 
    290                 295                 300                 


Val Arg Ala Val Asn Leu Gly Tyr Asp Val Asn Glu Leu Asp Ser Pro 
305                 310                 315                 320 


Ile Met Glu Phe Gly Gln Gly Tyr Lys Thr Asn Glu Ile Tyr Arg Gly 
                325                 330                 335     


Leu Lys Gln Ser Gly Val Tyr Glu Pro Ser Asn Val Thr Val Ser Tyr 
            340                 345                 350         


Phe Val Asp Pro Gln Leu Asn Tyr Asp Pro Gln Lys Arg Lys Glu Val 
        355                 360                 365             


Gly Cys Phe Val Lys Lys Leu Glu Ser Met Ser Glu Ala Leu Gly Val 
    370                 375                 380                 


Lys Leu Asn Val Ser Asp Gln Pro Arg Gln Leu Tyr Gly Gln Leu Pro 
385                 390                 395                 400 


Lys Asp Phe Leu Lys Gln Asp Asn Leu Ser Tyr His Leu Lys Ser Ile 
                405                 410                 415     


Thr Asp Gln Phe Arg Gly Thr Val Val Val Val Ile Gly Thr Glu Glu 
            420                 425                 430         


Asn Ile Asp Arg Ala Tyr Val Thr Ile Lys Lys Glu Phe Gly Gly Lys 
        435                 440                 445             


Glu Asp Leu Met Thr Gln Phe Val Gly Phe Thr Ser Ser Leu Val Thr 
    450                 455                 460                 


Glu Asn Asn Ile Phe His Tyr Tyr Asn Ile Leu Leu Gly Ile Tyr Ala 
465                 470                 475                 480 


Lys Ala Gly Val Gln Pro Trp Ile Leu Ala Ser Pro Met His Ser Asp 
                485                 490                 495     


Cys Phe Ile Gly Leu Asp Val Ser His Glu Tyr Gly Lys His Ala Ser 
            500                 505                 510         


Gly Ile Ile Gln Val Ile Gly Arg Asp Gly Lys Ile Ile Lys Gln Lys 
        515                 520                 525             


Leu Val Ala Thr Ala Glu Ala Gly Glu Ile Ile Ala Asn Ser Thr Met 
    530                 535                 540                 


Glu Glu Ile Val Asn Glu Ser Ile Tyr Ser Tyr Glu Gln Thr Tyr Gly 
545                 550                 555                 560 


Ala Lys Pro Arg His Ile Thr Phe His Arg Asp Gly Ile Cys Arg Glu 
                565                 570                 575     


Asp Leu Asp Phe Leu Gln Ala Tyr Leu Arg Ser Phe Gln Ile Pro Phe 
            580                 585                 590         


Asp Phe Val Glu Ile Ile Lys Lys Pro Arg Arg Arg Met Ala Ile Tyr 
        595                 600                 605             


Ser Asn Lys Lys Trp Val Thr Lys Gln Gly Ile Tyr Tyr Ser Lys Gly 
    610                 615                 620                 


Asn Thr Ala Tyr Leu Cys Ala Thr Asp Pro Arg Glu Ser Val Gly Met 
625                 630                 635                 640 


Ala Gln Leu Val Lys Ile Val Gln Lys Thr Asn Ser Leu Ser Val His 
                645                 650                 655     


Glu Ile Val Ser Asp Val Tyr Lys Leu Ser Phe Met His Ile His Ser 
            660                 665                 670         


Met Leu Lys Thr Arg Leu Pro Ile Thr Ile His Tyr Ala Asp Leu Ser 
        675                 680                 685             


Ser Thr Phe His Asn Arg Gly Leu Ile His Pro Arg Ser Gln Tyr Glu 
    690                 695                 700                 


Arg Ala Leu Pro Phe Val 
705                 710 


<210>  2
<211>  705
<212>  PRT
<213>  Clostridium sp. CAG:265


<220>
<221>  misc_feature
<223>  UniProt ID No: R6KUL9

<400>  2

Met Arg Glu Phe Asn Val Ile Thr Glu Phe Lys Asn Ser Ile Asn Ala 
1               5                   10                  15      


Asn Asn Ile Glu Ile Tyr Ile Tyr Lys Met Arg Val Arg Asp Phe Glu 
            20                  25                  30          


Asn Lys His Asn Glu Asn Tyr Asp Ile Val Lys Glu Leu Ile Lys Leu 
        35                  40                  45              


Asn Asn Asn Pro Thr Ile Ile Phe Tyr Glu Gln Tyr Ile Ala Ser Phe 
    50                  55                  60                  


Ile Glu Ile Gln Asn Trp Gly Ser Glu Lys Tyr Ile Asp Val Glu Lys 
65                  70                  75                  80  


Arg Ile Ile Thr Leu Asp Ser Asn Glu Lys Lys Ile Leu Glu Arg Leu 
                85                  90                  95      


Leu Leu Lys Glu Ile Lys Asp Ser Ile Asp Lys Glu Lys Tyr Lys Val 
            100                 105                 110         


Ile Lys Asn Ser Ile Tyr Ile Asn Lys Pro Val Tyr Tyr Glu Lys Gly 
        115                 120                 125             


Ile Lys Ile Asp Arg Tyr Phe Asn Phe Asp Ile Asn Ile Asn Cys Asn 
    130                 135                 140                 


Asn Glu Ile Ile Ile Gly Phe Asp Ala Lys His Ile Phe Glu Tyr Ile 
145                 150                 155                 160 


Asn Thr Leu Glu Cys Glu Ile Lys Asn Asp Asn Val Lys Ile Gly Asp 
                165                 170                 175     


Lys Val Lys Asp Tyr Phe Tyr Asn Leu Thr Tyr Glu Tyr Val Gly Ile 
            180                 185                 190         


Ala Pro Phe Thr Ile Ser Glu Ala Asn Glu Tyr Met Gly Cys Ser Ile 
        195                 200                 205             


Ile Asp Tyr Tyr Glu Asn Lys Asn Gln Gly Tyr Ile Val Asn Lys Leu 
    210                 215                 220                 


Pro Lys Asp Met Lys Ala Val Leu Val Lys Asn Asn Lys Asn Ser Ile 
225                 230                 235                 240 


Phe Pro Tyr Ile Pro Ser Arg Leu Lys Lys Val Cys Arg Phe Glu Asn 
                245                 250                 255     


Leu Pro Gln Asn Val Leu Lys Asp Phe Asn Asn Arg Val Lys Gln Lys 
            260                 265                 270         


Thr Asn Glu Lys Met Gln Phe Met Val Ser Glu Val Ile Asn Ile Val 
        275                 280                 285             


Lys Asn Ser Glu His Ile Asn Val Glu Lys Ile Asn Met Leu Cys Gly 
    290                 295                 300                 


Asn Ile Gly Tyr Lys Leu Lys Asp Leu Gln His Pro Asp Leu Leu Phe 
305                 310                 315                 320 


Gly Asn Ser Arg Ala Gln Lys Tyr Pro Leu Tyr Gly Leu Lys Asn Phe 
                325                 330                 335     


Gly Val Tyr Glu Asn Lys Thr Ile Glu Ile Lys Tyr Phe Ile Asp Pro 
            340                 345                 350         


Ile Leu Ala Lys Asn Asn Ile Asn Leu Lys Lys Val Ile Lys Phe Cys 
        355                 360                 365             


Asp Glu Leu Glu Cys Phe Ser Asn Met Leu Gly Val Lys Leu Asp Arg 
    370                 375                 380                 


Val Lys Leu Lys Asp Lys Val Asn Phe Lys Glu Ile Lys Ile Asp Asn 
385                 390                 395                 400 


Glu Asp Ile Phe Ser Tyr Glu Leu Lys Lys Ile Ala Ser Asn Tyr Asn 
                405                 410                 415     


Glu Thr Thr Ile Val Ile Leu Ser Glu Glu Asn Leu Ser Lys Tyr Tyr 
            420                 425                 430         


Asn Ile Ile Lys Lys Thr Phe Ser Gly Gly Asn Glu Ile Pro Thr Gln 
        435                 440                 445             


Cys Ile Gly Phe Asp Thr Leu Ser Tyr Asn Glu Lys Asn Lys Asp Ser 
    450                 455                 460                 


Ile Phe Phe Asn Ile Leu Leu Gly Ile Tyr Ala Lys Ser Gly Ile Gln 
465                 470                 475                 480 


Pro Trp Ile Leu Lys Glu Lys Leu Asn Ser Asp Cys Phe Ile Gly Leu 
                485                 490                 495     


Asp Val Ser Arg Glu Asn Lys Val Asn Lys Ala Gly Val Ile Gln Val 
            500                 505                 510         


Val Gly Lys Asp Gly Lys Val Leu Lys Thr Lys Val Ile Ser Ala Ser 
        515                 520                 525             


Gln Ser Gly Glu Lys Ile Lys Leu Glu Thr Leu Lys Glu Ile Val Phe 
    530                 535                 540                 


Glu Ala Val Gly Ser Tyr Glu Asn Ala Tyr Gly Cys Arg Pro Lys His 
545                 550                 555                 560 


Ile Thr Phe His Arg Asp Gly Ile Ser Arg Glu Glu Leu Glu Asn Leu 
                565                 570                 575     


Lys Asn Thr Met Asn Asn Leu Gly Ile Glu Phe Asp Tyr Ile Glu Ile 
            580                 585                 590         


Thr Lys Gly Ile Asn Arg Arg Ile Ala Thr Ile Ser Asp Asp Lys Gln 
        595                 600                 605             


Trp Lys Thr Val Met Gly Arg Cys Tyr Tyr Lys Asp Asp Ser Ala Phe 
    610                 615                 620                 


Ile Cys Thr Thr Lys Pro Tyr Glu Gly Met Gly Met Ala Gln Pro Ile 
625                 630                 635                 640 


Arg Ile Arg Arg Val Phe Gly Ser Leu Asp Ile Glu Lys Ile Val Glu 
                645                 650                 655     


Asp Ala Tyr Lys Leu Thr Phe Met His Val Gly Ala Ile Asn Lys Val 
            660                 665                 670         


Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp Leu Ser Ser Thr Tyr Gly 
        675                 680                 685             


Asn Arg Asp Leu Ile Pro Ser Asn Ile Asp Thr Asn Cys Leu Tyr Phe 
    690                 695                 700                 


Ile 
705 


<210>  3
<211>  721
<212>  PRT
<213>  Cyanothece sp. (strain PCC 7822)


<220>
<221>  misc_feature
<223>  UniProt ID No: E0UCX3

<400>  3

Met Asn Leu Asn Ser Asn Ala Glu Val Phe Leu Asn Ser Phe Pro Leu 
1               5                   10                  15      


Lys Arg Leu Ser Glu Gln Asp Arg Thr Val Gln Val Tyr Lys Tyr Asn 
            20                  25                  30          


Phe Lys Gln Ser Pro Glu Ala Gly Lys Glu Tyr Ser Ala Ile Ser Ser 
        35                  40                  45              


Ile Cys Trp Lys Val Asn Thr Pro Ala Thr Arg Phe Gln Glu Thr Ile 
    50                  55                  60                  


Ile Thr Lys Glu Lys Ile Ala Pro Glu Phe Leu Asn Asn Asp Asn Trp 
65                  70                  75                  80  


Ser Leu Gln Asp Gln Gly Ala Gln Val Leu Asp Thr Ser Asn Lys Ser 
                85                  90                  95      


Glu Asn Glu Ala Leu Lys Arg Leu Glu Lys Arg Trp Leu Glu Gln Lys 
            100                 105                 110         


Ile Lys Lys Ser Phe Lys Ser Ser Lys Ile Glu Arg Asp Thr Gln Ser 
        115                 120                 125             


Cys Leu Ile Trp Trp Asn Ala Glu Lys Val Ile Leu Ser Asn Leu Gly 
    130                 135                 140                 


Trp Glu Val His Thr Gly Val Cys Leu Asp Ile Leu Ile Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Phe Ile Glu Ile Asp Asp His His Ile Phe Tyr Ser Leu Trp 
                165                 170                 175     


Lys Leu Asn Lys Trp Leu Asn Ser Gly Tyr Lys Asn Leu Pro Ile Glu 
            180                 185                 190         


Tyr Val Arg Asn Thr Tyr Asp Asp Gln Thr Trp Lys Tyr Ala Arg Val 
        195                 200                 205             


Ser Asp Glu Lys Pro Glu Thr Val Met Ile Pro Gly Leu Gly Met Ser 
    210                 215                 220                 


Leu Ala Asp Tyr His Arg Asn His Lys Lys Tyr Pro Ala Thr Gln Glu 
225                 230                 235                 240 


Glu Ile Lys Asn Ser His Val Val Tyr Val Lys Asn Asn Asn Gly Gln 
                245                 250                 255     


Glu Ile Ala His Leu Ser Ser Arg Leu Arg Pro Ser Ile Thr Met Glu 
            260                 265                 270         


Ile Leu Ser Asn Leu Val Lys Phe Gly Asp Lys Glu Ala Ala Lys Val 
        275                 280                 285             


Phe Asn Gln Val Arg Lys Ser Ala Gln Ala Arg Phe Ser Lys Ala Glu 
    290                 295                 300                 


Glu Val Ile Gln Lys Ile Ala Glu Lys Ile Tyr Ser Leu Pro Thr Arg 
305                 310                 315                 320 


Ser Tyr Lys Pro Gln Lys Thr Asn Gly Val Leu Leu Arg Asn Lys Thr 
                325                 330                 335     


Pro Leu Leu Leu Thr Lys Lys Ser Asn Ile Arg Lys Pro Glu Ala Ser 
            340                 345                 350         


Leu Lys Gln Gly Cys Leu Arg Thr Gly Glu Gln Lys Phe Gly Cys Leu 
        355                 360                 365             


Ser Leu Ile Asp Ser Asn Ile Trp Pro Asn Leu Ile Lys Asn Lys Leu 
    370                 375                 380                 


Gln Leu Ala Ala Lys Ser Ser Asp Val Glu Ile Ile Leu Glu Glu Pro 
385                 390                 395                 400 


Lys Ile Lys Lys Asp Leu Pro Asp Ser Ser Leu Ser Arg Arg Gln Phe 
                405                 410                 415     


Trp Gln Asn Trp Ala Asp Glu Gly Thr Asn Thr Val Leu Val Val Ser 
            420                 425                 430         


Asn Trp Leu Gly Asn Asn Glu Lys Thr Gln Leu Arg Arg Glu Ala Leu 
        435                 440                 445             


Glu Ala Asn Ile Ala Leu Gln Phe Met Gln Pro Met Phe Lys Gln Glu 
    450                 455                 460                 


Asp Tyr Arg Ala Val Asn Ile Val Leu Gly Leu Leu Leu Lys Ala Lys 
465                 470                 475                 480 


Trp Gln Pro Val Gly Leu Glu Pro Leu Gln His Glu Gln Ala Ala Glu 
                485                 490                 495     


Leu Val Ile Gly Phe Asp Ala Gly Thr Asn Arg Ser Leu Tyr Tyr Gly 
            500                 505                 510         


Thr Ser Ala Phe Ala Val Leu Ala Asn Gly Gln Ser Leu Gly Trp Glu 
        515                 520                 525             


Leu Pro Glu Ala Gln Pro Gly Glu Arg Leu Ser Gly Gln Ala Val Leu 
    530                 535                 540                 


Arg Ala Thr Leu Asn Ile Val Asp Arg Phe Gln Lys Leu Glu Lys Arg 
545                 550                 555                 560 


Pro Pro Lys Arg Leu Leu Leu Leu Arg Asp Gly Phe Val Gln Arg Asp 
                565                 570                 575     


Glu Phe Asp Ser Thr Ile Ala Glu Leu Lys Gln Glu Asn Ile Ser Val 
            580                 585                 590         


Asp Leu Leu Gly Val Arg Lys Ser Gly Ala Gly Arg Met Ala Leu Ser 
        595                 600                 605             


Tyr Ser Pro Ser Pro Thr Glu Leu Pro Gln Leu Lys Asp Ala Pro Pro 
    610                 615                 620                 


Gly Met Ala Ile Phe Ser Gln Asp Gly Lys Thr Phe Lys Ile Val Thr 
625                 630                 635                 640 


Ser Glu Ala Lys Ala Gly Gly Ser Ala Arg Pro Leu Gln Ile Phe Arg 
                645                 650                 655     


Asp Thr Gly Asp Ala Pro Leu Glu Val Leu Ala Gln Gln Ile Asp Arg 
            660                 665                 670         


Leu Thr Met Leu Asn Pro Ala Ser Gly Tyr Phe Tyr Ser Arg Leu Pro 
        675                 680                 685             


Met Val Leu His Phe Ala Asp Lys Met Ala Lys Glu Val Gln Arg Leu 
    690                 695                 700                 


Gly Gln Ile Ala Phe Leu Gln Lys Val Glu Arg Glu Lys Ile Phe Phe 
705                 710                 715                 720 


Ala 
    


<210>  4
<211>  745
<212>  PRT
<213>  Dorea longicatena


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A174GIW5

<400>  4

Met Ser Lys Glu Leu Lys Met Glu Val Phe Ala Ser Lys Glu Pro Val 
1               5                   10                  15      


Lys Ser Val Lys Leu His Val Tyr Glu Phe His Thr Ser Glu Leu Tyr 
            20                  25                  30          


Glu Asn Lys Tyr Arg Leu Ile Arg Ser Ala Val Trp Lys Met Arg Asn 
        35                  40                  45              


Val Asn Ala Cys Gly Val Phe Glu Asp Gly Ser Tyr Ile Tyr Thr Thr 
    50                  55                  60                  


Glu Lys Ile Ser Glu Glu Ile Pro Asn Ala Thr Phe Arg Leu Thr Tyr 
65                  70                  75                  80  


Leu Gly Glu Gln Glu Leu Asn Val Leu Asp His Lys Lys Val Tyr Ser 
                85                  90                  95      


Glu Leu Ile Lys His Trp Ile Thr Gln Lys Leu Arg Thr Val Lys Ile 
            100                 105                 110         


Gln Lys Asn Ser Lys Glu Tyr Tyr Lys Tyr Ala Cys Arg Ser Asn Val 
        115                 120                 125             


Thr Ser Arg Trp Ile Gln Thr Glu Lys Gly Phe Gln Thr Phe Tyr Ser 
    130                 135                 140                 


Gly Asn Arg Gln Ile Ser Leu Glu Arg Lys Tyr Asn Phe Thr Val Lys 
145                 150                 155                 160 


Ile Leu Asp Asp Gly Lys Ala Tyr Leu Lys Ile Asp Thr Ser Ser Val 
                165                 170                 175     


Phe Ser Ser Asn Gln Thr Val Tyr Asp Tyr Ile Thr Gln Gly Met Asn 
            180                 185                 190         


Pro Ile Gly Met Glu Val Lys Asn Glu Trp Gly Lys Asn Asn Gln Thr 
        195                 200                 205             


Gly Ile Leu Thr Glu Ile Cys Asp Tyr Thr Val Val Asn Lys Ile Asp 
    210                 215                 220                 


Phe Ala Asp Ser Leu Lys Ala Tyr Tyr Thr Asp Met Lys Lys Glu Gly 
225                 230                 235                 240 


Tyr Arg Val Glu Asn Leu Pro Asp Gln Thr Pro Val Val Arg Val Glu 
                245                 250                 255     


Leu Gln Val Gly Lys Ile Tyr Pro Tyr Tyr Pro Gln Ala Leu Lys Pro 
            260                 265                 270         


Val Leu Thr Arg Glu Lys Val Gly Gln Ile Asp Ala Arg Phe Ser Met 
        275                 280                 285             


Ala Ile Glu Lys Tyr Ile Lys Arg Asp Met Ile Thr Arg Ile Glu Leu 
    290                 295                 300                 


Asp Lys Asp Phe Ile Gln Asp Ile Gly Ser Ile Ala Gln Leu Gly Asp 
305                 310                 315                 320 


Leu Glu Phe Glu Asn Asp Met Cys Asn Val Lys Glu Leu Gly Tyr Leu 
                325                 330                 335     


Lys Gly Lys Val Glu Ser Pro Ala Leu Thr Cys Gly Gln Gly Lys Arg 
            340                 345                 350         


Leu Arg Cys Gly Glu Glu Phe Lys Val Phe Asn Tyr Gly Phe Tyr Gln 
        355                 360                 365             


Lys Pro Asp Glu Lys Ile Lys Ile Gly Tyr Ile Tyr Pro Lys Asn Thr 
    370                 375                 380                 


Val Asp Leu Ile Lys Ala Val Val Asn Gly Ile Cys Glu Phe Ala Ala 
385                 390                 395                 400 


Tyr Gly Lys Tyr Gln Gly Glu Lys Asp Ala Tyr Ile Ile Pro Gly Leu 
                405                 410                 415     


Leu Asp Ile Gln Met Lys Pro Met Ile Lys Glu Glu Tyr Glu Leu Gly 
            420                 425                 430         


Asp Ile Thr Asp Tyr Lys Arg Ala Ala Gln Arg Leu Arg Lys Val Glu 
        435                 440                 445             


Gly Ile Asp Ile Val Ile Gly Ile Val Pro Asp Gly Met Asp Glu Asp 
    450                 455                 460                 


Gly Pro Tyr Asn Pro Phe Lys Thr Ile Trp Ala Glu Ala Asn Ile Pro 
465                 470                 475                 480 


Ser Gln Met Ile Ser Met Lys Thr Ala Gln Leu Phe Tyr Arg Gly Lys 
                485                 490                 495     


Arg Glu Gly Asn Lys Ser Lys Tyr Tyr Leu His Asn Ile Val Leu Gly 
            500                 505                 510         


Ile Leu Gly Lys Thr Gly Gly Ile Pro Trp Val Ile Lys Glu Met Pro 
        515                 520                 525             


Gly Asn Val Asp Cys Phe Val Gly Leu Asp Val Ala Ile Leu Glu Lys 
    530                 535                 540                 


Gly Ile His Tyr Pro Ala Cys Ser Val Val Phe Asp Lys Ser Gly Arg 
545                 550                 555                 560 


Leu Leu Gly Phe Tyr Lys Pro Lys Ser Ala Gln Arg Gly Glu Lys Ile 
                565                 570                 575     


Glu Thr Arg Ile Leu Gln Asp Ile Phe Asp Gln Val Leu Leu Ser Tyr 
            580                 585                 590         


Glu Glu Lys Phe Gly Glu Gln Pro Lys Asn Ile Met Ile His Arg Asp 
        595                 600                 605             


Gly Phe Ser Asn Glu Asn Asp Ala Trp Tyr Glu Lys Tyr Phe Gly Ala 
    610                 615                 620                 


Lys Gly Ile Ala Tyr Thr Ile Val Glu Val Arg Lys Asn Ile Ser Ser 
625                 630                 635                 640 


Lys Leu Ala Ile Ile Glu Asp Gly Val Ile Lys Asn Pro Glu Met Gly 
                645                 650                 655     


Tyr Cys Ile Tyr Asn Asn Asn Lys Gly Tyr Leu Val Thr Thr Asn Met 
            660                 665                 670         


Lys Asn Lys Lys Gly Ser Pro Asn Pro Leu Leu Leu Glu Lys Lys Cys 
        675                 680                 685             


Gly Asp Val Pro Met Thr Ile Ile Leu Lys Gln Val Leu Tyr Leu Ser 
    690                 695                 700                 


Gln Leu His Val Gly Ser Thr Gln Lys Met Arg Leu Pro Ile Thr Thr 
705                 710                 715                 720 


Gly Tyr Ala Asp Lys Ile Cys Lys Asn Arg Glu Phe Val Pro Glu Gly 
                725                 730                 735     


Lys Met Asp Asn Arg Leu Phe Phe Leu 
            740                 745 


<210>  5
<211>  740
<212>  PRT
<213>  Eubacterium sp. CAG:603


<220>
<221>  misc_feature
<223>  UniProt ID No: R5NJJ8

<400>  5

Met Glu Lys Asp Leu Arg Met Glu Val Phe Ser Ser Lys Asp Ile Val 
1               5                   10                  15      


Arg Ala Thr Cys Leu His Val Tyr Gln Leu His Thr Gln Lys Ile Asp 
            20                  25                  30          


Asn Thr Phe Ser Ile Ile Arg Gly Ala Ala Trp Lys Leu Arg Asn Tyr 
        35                  40                  45              


Phe His Val Gly Val Phe Glu Asp Gly Lys Arg Ile Tyr Thr Thr Glu 
    50                  55                  60                  


Lys Ile Glu Gly Thr Val Pro Asn Ala Asp Phe Ile Ile Glu Tyr Glu 
65                  70                  75                  80  


Gly Phe Lys Glu Leu Pro Val Leu Glu Asn Arg Lys Ile Tyr Cys Glu 
                85                  90                  95      


Leu Ile Lys His Phe Ile Thr Gln Asn Leu Ser Glu Val Met Val Tyr 
            100                 105                 110         


Asp Lys Tyr Arg Lys Tyr Ser Cys Lys Ser Ser Val Thr Ser Lys Trp 
        115                 120                 125             


Ile Met Thr Asn Gln Gly Phe Lys Thr Phe Ile Ser Lys Asn Lys Glu 
    130                 135                 140                 


Ile Ser Leu Glu Arg Lys Tyr Asn Phe Trp Val Glu Ile Leu Asp Asn 
145                 150                 155                 160 


Gly Lys Ala Tyr Leu Arg Leu Asp Thr Gly Ser Val Phe Thr Ser Asn 
                165                 170                 175     


Leu Thr Val Asn Asp Tyr Leu Val Lys Gly Val Asp Pro Ile Gly Met 
            180                 185                 190         


Glu Val Lys Asn Asp Trp Ala Lys Asn Asn Gln Thr Gly Ile Leu Thr 
        195                 200                 205             


Glu Ile Cys Asp Phe Thr Val Thr Asp Lys Leu Asp Phe Thr Asp Ser 
    210                 215                 220                 


Leu Lys Ala Tyr Tyr Ile Glu Arg Lys Glu Gly Tyr Arg Val Glu Lys 
225                 230                 235                 240 


Ile Pro Asp Asp Thr Lys Val Val Lys Val Glu Leu Gln Pro Gly Lys 
                245                 250                 255     


Ser Tyr Pro Tyr Tyr Pro Gln Ala Leu Lys Pro Val Leu Thr Arg Glu 
            260                 265                 270         


Lys Val Gly Gln Ile Asp Ala Thr Phe Ser Leu Gln Ile Asp Ser Tyr 
        275                 280                 285             


Val Lys Arg Asn Met Gln Thr Arg Leu Gln Leu Asp Ile Asp Phe Ile 
    290                 295                 300                 


Lys Asp Val Gly Ser Leu Ser Glu Leu Ser Asp Leu Glu Phe Asn Thr 
305                 310                 315                 320 


Glu Thr Cys Thr Val Glu Glu Ile Gly Tyr Thr Lys Gly Thr Val Pro 
                325                 330                 335     


Leu Pro Asn Leu Ile Cys Gly Lys Asp Lys Ala Leu Glu Cys Gly Lys 
            340                 345                 350         


Glu Leu Gln Val Phe Asn Tyr Gly Phe Tyr Arg Lys Thr Asp Arg Lys 
        355                 360                 365             


Ile Lys Ile Gly Tyr Ile Tyr Pro Lys Asn Thr Phe Asp Lys Met Lys 
    370                 375                 380                 


Ala Val Val Asn Glu Ile Tyr Ser Phe Ala Lys Leu Gly Lys Tyr Gln 
385                 390                 395                 400 


Gly Glu Lys Asp Lys Tyr Ile Val Glu Gly Leu Leu Asp Ile Gln Ala 
                405                 410                 415     


Glu Pro Met Ile Lys Glu Glu Tyr Glu Leu Gly Asp Leu Thr Asp Tyr 
            420                 425                 430         


Lys Arg Ala Ala Asn Arg Leu Gln Lys Val Lys Gly Ile Asp Ile Val 
        435                 440                 445             


Ile Ala Leu Ile Pro Asp Gly Ile Asp Glu Asp Gly Pro Tyr Asn Pro 
    450                 455                 460                 


Phe Lys Thr Ile Trp Ala Lys Ala Asn Ile Pro Ser Gln Met Ile Ser 
465                 470                 475                 480 


Met Lys Thr Ala Glu Leu Phe Ala Arg Gly Lys Ser Glu Gly Asn Lys 
                485                 490                 495     


Ser Lys Tyr Tyr Leu His Asn Ile Ile Leu Gly Ile Leu Gly Lys Thr 
            500                 505                 510         


Gly Gly Ile Pro Trp Ile Val Lys Asp Met Pro Gly Asn Val Asp Cys 
        515                 520                 525             


Phe Val Gly Leu Asp Val Ala Thr Val Ala Lys Gly Ile His Tyr Pro 
    530                 535                 540                 


Ala Cys Ser Val Val Phe Asp Lys Tyr Gly Arg Leu Leu Gly Phe Tyr 
545                 550                 555                 560 


Lys Pro Thr Thr Pro Gln Gln Gly Glu Lys Ile Thr Thr Arg Ile Leu 
                565                 570                 575     


Gln Asp Ile Phe Asp Gln Val Ile Phe Ser Tyr Glu Asp Arg Phe Glu 
            580                 585                 590         


Glu Met Pro Lys Asn Val Val Ile His Arg Asp Gly Phe Ser Asn Glu 
        595                 600                 605             


Asn Asp Asp Trp Tyr Arg Asn Tyr Phe Gly Ala Lys Gly Ile Glu Tyr 
    610                 615                 620                 


Ser Ile Ile Glu Val Arg Lys Asn Val Ser Ser Lys Leu Ile Leu Leu 
625                 630                 635                 640 


Gln Asp Asp Lys Ile Met Asn Pro Thr Met Gly Tyr Cys Val Tyr Asn 
                645                 650                 655     


Asn Asn Lys Gly Tyr Leu Val Thr Thr Asp Met Lys Asn Lys Lys Gly 
            660                 665                 670         


Ser Pro Asn Pro Ile Leu Val Glu Lys Lys Cys Gly Asn Val Ser Met 
        675                 680                 685             


Ala His Ile Leu Thr Gln Ile Leu Tyr Leu Ser Gln Leu His Val Gly 
    690                 695                 700                 


Ser Thr His Lys Met Arg Leu Pro Ile Thr Thr Gly Tyr Ala Asp Lys 
705                 710                 715                 720 


Ile Cys Lys Asn Arg Asp Phe Val Pro Glu Gly Lys Met Asp Asp Arg 
                725                 730                 735     


Leu Phe Phe Leu 
            740 


<210>  6
<211>  744
<212>  PRT
<213>  Fusicatenibacter saccharivorans


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A174T2R9

<400>  6

Met Glu Lys Asp Leu Lys Met Glu Val Phe Ala Ser Val Asp Thr Val 
1               5                   10                  15      


Lys Pro Val Glu Phe His Val Tyr Glu Leu His Val Gln Lys Ile Gly 
            20                  25                  30          


Asn Thr Tyr Ser Ile Ile Arg Gly Ala Ala Trp Lys Leu Arg Asn Trp 
        35                  40                  45              


Asn Gln Ala Gly Val Phe Glu Asp Gly Asn Lys Ile Tyr Ala Thr Glu 
    50                  55                  60                  


Lys Leu Gln Glu Lys Ile Pro Asn Ala Asp Phe Thr Val Glu Tyr Glu 
65                  70                  75                  80  


Gly Ser Arg Glu Leu Pro Val Leu Glu Asn Arg Arg Ile Tyr Gln Glu 
                85                  90                  95      


Leu Ile Lys Tyr Trp Ile Thr Gln Lys Leu Ser Gln Ile Leu Ile Phe 
            100                 105                 110         


Gly Lys Tyr Arg Lys Tyr Ser Cys Lys Ser Asn Val Thr Ser Lys Trp 
        115                 120                 125             


Ile Met Thr Asn Gln Gly Phe Glu Thr Phe Ser Ser Gly Asn Arg Glu 
    130                 135                 140                 


Ile Ser Leu Glu Arg Lys Tyr Asn Phe Trp Val Thr Ile Met Asp Asp 
145                 150                 155                 160 


Glu Lys Ala Tyr Leu Arg Ile Asp Thr Ser Ser Leu Phe Ser Ser Asn 
                165                 170                 175     


Gln Thr Val Ala Asp Tyr Leu Glu Lys Gly Leu Asn Leu Ile Gly Gln 
            180                 185                 190         


Glu Val Lys Asn Asp Trp Ala Lys Asn Asn Gln Thr Gly Ile Leu Thr 
        195                 200                 205             


Glu Ile Cys Asp Leu Thr Val Thr Asp Lys Leu Asp Phe Ala Asp Ser 
    210                 215                 220                 


Leu Lys Ala Tyr Tyr Ile Gln Arg Asn Glu Ala Tyr Arg Val Glu Asn 
225                 230                 235                 240 


Ile Ser Asp Asp Thr Arg Met Val Lys Val Ala Leu Gln Thr Gly Ile 
                245                 250                 255     


Glu Leu Pro Tyr Tyr Pro Gln Ala Leu Lys Pro Val Leu Thr Arg Glu 
            260                 265                 270         


Thr Val Ser Arg Met Asp Ala Ala Phe Ser Met Arg Thr Glu Ser Leu 
        275                 280                 285             


Val Lys Arg Asn Met Lys Thr Arg Val Leu Leu Asp Gln Asp Phe Ile 
    290                 295                 300                 


Gln Asp Ile Gly Thr Ile Glu Pro Leu Asp Gly Met Lys Phe Glu Thr 
305                 310                 315                 320 


Asp Pro Cys Thr Val Glu Lys Ile Gly Tyr Lys Lys Gly Lys Val Lys 
                325                 330                 335     


Glu Pro Leu Leu Val Cys Gly Lys Asp Lys Ala Leu Lys Cys Gly Glu 
            340                 345                 350         


Glu Phe Lys Val Phe Asn Tyr Gly Phe Tyr Arg Lys Thr Glu Lys Glu 
        355                 360                 365             


Ile Lys Ile Gly Tyr Leu Tyr Pro Arg Asn Ser Tyr Asp Leu Met Lys 
    370                 375                 380                 


Ala Val Val Asn Gly Ile Tyr Thr Phe Ala Lys Leu Gly Lys Tyr His 
385                 390                 395                 400 


Gly Glu Lys Asp Leu Tyr Thr Met Ala Gly Leu Leu Asp Leu Asp Val 
                405                 410                 415     


Lys Ala Met Val Arg Glu Glu Tyr Glu Leu Gly Asp Ile Thr Asp Tyr 
            420                 425                 430         


Lys Arg Ala Ala Asn Lys Leu Gln Lys Ile Glu Gly Ile Asp Leu Val 
        435                 440                 445             


Ile Ala Leu Val Pro Asp Gly Met Glu Glu Asp Gly Pro Tyr Asn Pro 
    450                 455                 460                 


Phe Lys Thr Ile Trp Ala Lys Ala Asn Ile Pro Ser Gln Met Ile Ser 
465                 470                 475                 480 


Met Lys Thr Ala Lys Leu Phe Ala Glu Glu Ala Lys Glu Gly Asn Lys 
                485                 490                 495     


Ala Lys Asn Ser Ser Arg Tyr Tyr Leu His Asn Ile Ile Leu Gly Ile 
            500                 505                 510         


Leu Gly Lys Thr Gly Gly Ile Pro Trp Val Val Lys Asp Met Pro Gly 
        515                 520                 525             


Asn Val Asp Cys Phe Val Gly Leu Asp Val Ala Thr Ile Ala Lys Gly 
    530                 535                 540                 


Ile His Tyr Pro Ala Cys Ser Val Val Phe Asp Lys Tyr Gly Arg Leu 
545                 550                 555                 560 


Leu Gly Phe Tyr Lys Pro Ala Ala Pro Gln Gln Gly Glu Lys Ile Thr 
                565                 570                 575     


Thr Arg Ile Leu Gln Asp Ile Phe Asp Gln Val Ile Phe Ala Tyr Glu 
            580                 585                 590         


Asp Arg Phe Gly Glu Met Pro Lys Asn Ile Val Ile His Arg Asp Gly 
        595                 600                 605             


Phe Ser Asn Glu Asp Asp Glu Trp Tyr Lys Asn Tyr Phe Ala Ala Lys 
    610                 615                 620                 


Gly Ile Met Tyr Asn Ile Ile Glu Val Arg Lys Asn Ile Ser Ser Lys 
625                 630                 635                 640 


Leu Ile Phe Trp Gln Asn Gly Gln Ile Glu Asn Pro Pro Met Gly Tyr 
                645                 650                 655     


Cys Val Tyr Asn Ala Asp Lys Gly Tyr Leu Val Thr Thr Asn Met Lys 
            660                 665                 670         


Asn Lys Lys Gly Ser Pro Asn Pro Ile Leu Ile Glu Lys Lys Cys Gly 
        675                 680                 685             


Asn Leu Ser Met Ala Asp Ile Leu Thr Gln Val Leu Tyr Leu Ser Gln 
    690                 695                 700                 


Leu His Val Gly Ser Thr Gln Lys Met Arg Leu Pro Ile Thr Thr Gly 
705                 710                 715                 720 


Tyr Ala Asp Lys Ile Cys Lys Asn Arg Glu Phe Val Pro Glu Gly Lys 
                725                 730                 735     


Met Asp Asp Arg Leu Phe Phe Leu 
            740                 


<210>  7
<211>  504
<212>  PRT
<213>  Halarchaeum acidiphilum MH1-52-1


<220>
<221>  misc_feature
<223>  UniProt ID No: U3A1K8

<400>  7

Met His Glu Gly Val Ala Asp Glu Glu Trp Arg Gln Lys Leu Ile Gln 
1               5                   10                  15      


Asp Asp Pro Arg Leu Leu Lys Ile Lys Tyr Gly Ser Asn Val Arg Asn 
            20                  25                  30          


Gln Ala Pro His Phe Leu Lys Leu Ala Pro Arg Ile Glu Gln Val Gln 
        35                  40                  45              


Asp Glu Asp Tyr Ala Phe Phe Gln Arg Phe Ala Ser Arg Arg Ser Met 
    50                  55                  60                  


Met Pro Gly Glu Lys Phe Glu Tyr Thr Lys Glu Phe Ile Glu Ser Leu 
65                  70                  75                  80  


Ser Trp Leu Pro Val Leu Glu Leu Ala Phe Glu Pro Gly Pro Thr Asn 
                85                  90                  95      


Asp Gly Tyr Asn Ser Ile Asp Ile Arg Gly Thr Arg Asp Arg Leu Ile 
            100                 105                 110         


Phe Gln Asn Ser Ala Pro Ala Asn Asn Pro Ser Ala Gly Leu Arg Gln 
        115                 120                 125             


Tyr Gly Val Tyr Gln Ser Pro Gly Gln Tyr Arg Val Gly Val Leu Val 
    130                 135                 140                 


Pro Glu Ala Trp Ser Glu Ile Gln Arg Glu Phe Pro Gly Leu Ile Thr 
145                 150                 155                 160 


Lys Gly Leu Ala Glu Ile Gln Ala Pro Gly Gly Val Thr Lys Tyr Glu 
                165                 170                 175     


Tyr Glu Leu Gly Asp Ile Ser Lys Tyr Thr Pro Ile Ala His Gln Leu 
            180                 185                 190         


His Asp Glu Thr Glu Val Val Val Ala Val Val Pro Asp Pro Gly Lys 
        195                 200                 205             


Ser Glu Gln Phe Gly Ile Glu Asp Pro His His Glu Val Lys Arg Thr 
    210                 215                 220                 


Leu Met Arg Gln Gly Val Pro Thr Gln Met Thr Thr Lys Ser Thr Val 
225                 230                 235                 240 


Asp Glu Leu Ile Lys Leu Gly Ala Asp Ala Gly Asn Asp Lys Met Leu 
                245                 250                 255     


Asn Ile Leu Ser Ala Val Val Gly Lys Ala Gly Gly Thr Pro Trp His 
            260                 265                 270         


Ile His Asp Met Pro Gly Glu Thr Asp Ala Phe Met Gly Leu Asp Val 
        275                 280                 285             


Ser His Asp Gln Ser Ser Asp Lys His Thr Gly Ala Ser Ala Ser Val 
    290                 295                 300                 


Val Leu Ser Asp Gly Thr Thr Tyr Ala Ala Glu Ser Thr Val Gly Gln 
305                 310                 315                 320 


Ser Gly Glu Thr Phe Ser Ala Glu His Val Gln Gln Phe Val Arg Asp 
                325                 330                 335     


Leu Val Phe Asp Phe Ala Met Glu Gln Gly Thr Glu Ile Asn Arg Leu 
            340                 345                 350         


Cys Ile Met Arg Asp Gly Lys Ile Ser Glu Asp Ile Asp Ala Ile Arg 
        355                 360                 365             


Asp Gly Leu Ser Glu Leu Ser Ala Glu Ile Asp Ile Val Gly Val Arg 
    370                 375                 380                 


Lys Ser Gly Gln Pro Arg Val Ala Glu Tyr Asp Gly Thr His Phe Tyr 
385                 390                 395                 400 


Ile Ala Gln Lys Gly Val Ala Phe Val Ser Asp Gly Gln Gly His Ala 
                405                 410                 415     


Ile Ile His Gly Ser Gly Lys Pro Glu Ile Lys Asp Asp Asn Ser Val 
            420                 425                 430         


Gly Thr Pro Gln Thr Tyr Arg Ile Thr Arg His Ser Gly Pro Thr Asp 
        435                 440                 445             


Ile Glu Thr Leu Ala Arg Gln Ala Tyr Trp Leu Ser Glu Val His Ile 
    450                 455                 460                 


Gly Ser Pro Val Arg Ser Pro Arg Leu Pro Ile Pro Ile Gly Tyr Ala 
465                 470                 475                 480 


Asp Lys Ala Ala Ser Tyr Val Ser Asp Glu Ile Val Ser Pro Gly Thr 
                485                 490                 495     


Val Ile Lys Gly Pro Ala Tyr Ile 
            500                 


<210>  8
<211>  736
<212>  PRT
<213>  Intestinibacter bartlettii DSM 16795


<220>
<221>  misc_feature
<223>  UniProt ID No: B0ADC8

<400>  8

Met Val Ser Leu Asp Arg Glu Phe Asn Val Ile Thr Glu Phe Lys Asn 
1               5                   10                  15      


Glu Leu Lys Pro Glu Asp Ile Lys Ile Phe Leu Tyr Ser Met Pro Ile 
            20                  25                  30          


Lys Asp Ile Asn Glu Arg His Ser Glu Asn Tyr Ala Ile Val Gln Glu 
        35                  40                  45              


Leu Lys Lys Ile Asn Glu Asn Pro Asn Ile Val Phe Asn Glu Tyr Ile 
    50                  55                  60                  


Ile Ala Ser Phe Asn Pro Ile Ile Asn Trp Gly Lys Tyr Lys Asp Ile 
65                  70                  75                  80  


Asp Val Lys Pro Asp Asn Arg Asn Ile Asn Leu Asp Asn Ser Thr Glu 
                85                  90                  95      


Arg Lys Ile Leu Glu Arg Leu Leu Leu Cys Asp Ile Lys Asn Asn Ile 
            100                 105                 110         


Asn Asn Asn Thr Thr Trp Ala Gln Gln Asn Lys Tyr Glu Ile Arg Gly 
        115                 120                 125             


Asn Ala Asn Pro Ala Val Tyr Leu Arg Lys Pro Ile Tyr Leu Asn Asp 
    130                 135                 140                 


Asn Leu Ile Ile Arg Arg Lys Leu Asn Phe Asp Val Asn Ile Asp Lys 
145                 150                 155                 160 


Lys Asp Ile Ile Ile Gly Phe Phe Leu Asn His Glu Phe Glu Tyr Gln 
                165                 170                 175     


Lys Thr Leu Asp Glu Glu Ile Lys Cys Gly Asn Ile Gln Lys Gly Asp 
            180                 185                 190         


Lys Val Lys Asp Phe Tyr Asn Asn Ile Thr Tyr Glu Phe Leu Glu Met 
        195                 200                 205             


Ala Pro Phe Ser Ile Ser Gln Glu Asn Lys Tyr Met Arg Ser Ser Ile 
    210                 215                 220                 


Ile Glu Tyr Tyr Leu Asn Lys Gly Gln Ser Tyr Ile Ile Ser Gly Leu 
225                 230                 235                 240 


Asp Lys Asn Thr Lys Ala Val Leu Val Lys Asn Lys Glu Gly Ser Ile 
                245                 250                 255     


Phe Pro Tyr Ile Pro Asn Arg Leu Lys Lys Ile Cys Val Phe Glu Asn 
            260                 265                 270         


Leu Gly Asn Arg Arg Ile Ile Glu Gly Asn Lys Tyr Ile Lys Met Asn 
        275                 280                 285             


Pro Ser Gln Asn Met Ser Glu Ser Ile Lys Leu Ala Glu Asp Ile Leu 
    290                 295                 300                 


Lys Asn Ser Lys Tyr Val Lys Phe Asn Lys Ala Asn Met Ile Val Glu 
305                 310                 315                 320 


Lys Ile Gly Tyr Lys Lys Asp Ile Val Lys Arg Pro Ala Leu Lys Phe 
                325                 330                 335     


Gly Lys Asn Glu Ser Asn Phe Ser Ala Met Tyr Gly Leu Asn Lys Ser 
            340                 345                 350         


Gly Ser Tyr Glu Gln Lys Asn Ile Glu Ile Asp Tyr Phe Ile Asp Pro 
        355                 360                 365             


Lys Ile Leu Asn Asn Lys Arg Asp Tyr Gln Ile Val Tyr Ser Phe Leu 
    370                 375                 380                 


Asn Asp Ile Ile Ser Lys Ser Lys Asp Leu Gly Val Glu Ile Asn Thr 
385                 390                 395                 400 


Asp Lys Ser Tyr Ile Asn Leu Thr Pro Ile Asn Ile Lys Asn Glu Asn 
                405                 410                 415     


Val Phe Glu Leu Asn Ile Ile Gln Ile Ile Glu Asn Tyr Asn Asn Pro 
            420                 425                 430         


Val Leu Val Ile Leu Glu Lys Glu Asn Ile Asp Lys Tyr Tyr Glu Thr 
        435                 440                 445             


Leu Lys Lys Ile Phe Gly Gly Arg Asn Asn Ile Pro Thr Gln Phe Val 
    450                 455                 460                 


Asp Leu Asp Thr Ile Lys Lys Cys Asp Pro Lys Ile Asp Asn Lys Arg 
465                 470                 475                 480 


Gly Lys Glu Ser Ile Phe Leu Asn Ile Leu Leu Gly Ile Tyr Cys Lys 
                485                 490                 495     


Ser Gly Ile Gln Pro Trp Val Leu Ala Asn Gly Leu Ser Ala Asp Cys 
            500                 505                 510         


Tyr Ile Gly Leu Asp Val Cys Arg Glu Asn Asn Met Ser Thr Ala Gly 
        515                 520                 525             


Leu Ile Gln Val Ile Gly Lys Asp Gly Arg Val Leu Lys Ser Lys Thr 
    530                 535                 540                 


Ile Ser Ser His Gln Ser Gly Glu Lys Ile Gln Ile Asn Ile Leu Lys 
545                 550                 555                 560 


Asp Ile Ile Phe Glu Ala Lys Gln Ala Tyr Lys Asn Thr Tyr Asn Lys 
                565                 570                 575     


Lys Leu Glu His Ile Val Phe His Arg Asp Gly Ile Asn Arg Glu Asp 
            580                 585                 590         


Ile Asp Leu Leu Lys Glu Ile Thr Asn Ser Leu Glu Ile Lys Phe Asp 
        595                 600                 605             


Tyr Val Glu Val Thr Lys Asn Ile Asn Arg Arg Met Ala Met Leu Glu 
    610                 615                 620                 


Lys Ser Asp Glu Asn Tyr Asn His Arg Asp Lys Glu Asn Lys Lys Trp 
625                 630                 635                 640 


Ile Thr Glu Ile Gly Met Cys Leu Lys Lys Glu Asn Glu Ala Tyr Leu 
                645                 650                 655     


Ile Thr Thr Asn Pro Ser Glu Asn Met Gly Met Ala Arg Pro Leu Arg 
            660                 665                 670         


Ile Lys Lys Val Tyr Gly Asn Gln Asn Met Asp Asp Ile Val Lys Asp 
        675                 680                 685             


Ile Tyr Lys Leu Ser Phe Met His Ile Gly Ser Ile Met Lys Ser Arg 
    690                 695                 700                 


Leu Pro Ile Thr Thr Tyr Tyr Ala Asp Leu Ser Ser Ile Tyr Ser His 
705                 710                 715                 720 


Arg Glu Leu Met Pro Lys Ser Val Asp Asn Asn Ile Leu His Phe Ile 
                725                 730                 735     


<210>  9
<211>  736
<212>  PRT
<213>  Intestinibacter bartlettii


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A174GM97

<400>  9

Met Val Ser Leu Asp Arg Glu Phe Asn Val Ile Thr Glu Phe Lys Asn 
1               5                   10                  15      


Glu Leu Lys Pro Glu Asp Ile Lys Ile Phe Leu Tyr Ser Met Pro Ile 
            20                  25                  30          


Lys Asp Ile Asn Glu Arg His Ser Glu Asn Tyr Ala Ile Val Gln Glu 
        35                  40                  45              


Leu Lys Lys Ile Asn Glu Asn Pro Asn Ile Val Phe Asn Glu Tyr Ile 
    50                  55                  60                  


Ile Ala Ser Phe Asn Pro Ile Ile Asn Trp Gly Lys Tyr Lys Asp Ile 
65                  70                  75                  80  


Asp Val Lys Pro Asp Asn Arg Asn Ile Asn Leu Asp Asn His Thr Glu 
                85                  90                  95      


Arg Lys Ile Leu Glu Arg Leu Leu Leu Cys Asp Ile Lys Asn Asn Ile 
            100                 105                 110         


Asn Asn Asn Thr Thr Trp Glu Gln Gln Asn Lys Tyr Glu Ile Arg Gly 
        115                 120                 125             


Asn Ala Asn Pro Ala Val Tyr Leu Arg Arg Pro Ile Tyr Ser Asn Asn 
    130                 135                 140                 


Asn Leu Ile Ile Arg Arg Lys Leu Asn Phe Asp Val Asn Ile Asp Lys 
145                 150                 155                 160 


Lys Asp Ile Ile Ile Gly Phe Phe Leu Asn His Glu Phe Glu Tyr Gln 
                165                 170                 175     


Lys Thr Leu Asp Glu Glu Ile Lys Cys Gly Asn Ile Gln Lys Gly Asp 
            180                 185                 190         


Lys Val Lys Asp Phe Tyr Asn Asn Ile Thr Tyr Glu Phe Leu Glu Ile 
        195                 200                 205             


Ala Pro Phe Ser Ile Ser Gln Glu Asn Lys Tyr Met Arg Ser Ser Ile 
    210                 215                 220                 


Ile Glu Tyr Tyr Leu Asn Lys Gly Gln Ser Tyr Ile Ile Ser Gly Leu 
225                 230                 235                 240 


Asp Lys Asn Thr Lys Ala Val Leu Val Lys Asn Lys Glu Gly Ser Ile 
                245                 250                 255     


Phe Pro Tyr Ile Pro Asn Arg Leu Lys Lys Ile Cys Val Phe Glu Asn 
            260                 265                 270         


Leu Gly Asn Arg Arg Ile Ile Glu Gly Asn Lys Tyr Ile Lys Met Asn 
        275                 280                 285             


Pro Ser Gln Asn Met Ser Glu Ser Ile Lys Leu Ala Glu Gly Ile Leu 
    290                 295                 300                 


Lys Asn Ser Lys Tyr Val Lys Phe Asn Lys Ala Asn Met Ile Val Glu 
305                 310                 315                 320 


Lys Ile Gly Tyr Lys Lys Asp Ile Val Lys Arg Pro Ala Leu Lys Phe 
                325                 330                 335     


Gly Lys Asn Glu Ser Asn Phe Ser Ala Met Tyr Gly Leu Asn Lys Ser 
            340                 345                 350         


Gly Ser Tyr Glu Gln Lys Asn Ile Lys Ile Asp Tyr Phe Ile Asp Pro 
        355                 360                 365             


Lys Ile Leu Asn Asn Lys Arg Asp Tyr Gln Ile Val Tyr Ser Phe Leu 
    370                 375                 380                 


Asn Asp Ile Ile Ser Lys Ser Lys Asp Leu Gly Val Glu Ile Asn Thr 
385                 390                 395                 400 


Asp Lys Ser Tyr Ile Asn Leu Thr Pro Ile Asn Ile Lys Asn Glu Asn 
                405                 410                 415     


Val Phe Glu Leu Asn Ile Ile Gln Ile Ile Glu Asn Tyr Asn Asn Pro 
            420                 425                 430         


Val Leu Val Ile Leu Glu Lys Glu Asn Ile Asp Lys Tyr Tyr Glu Thr 
        435                 440                 445             


Leu Lys Lys Ile Phe Gly Gly Arg Asn Asn Ile Pro Thr Gln Phe Val 
    450                 455                 460                 


Asp Leu Asp Thr Ile Lys Lys Cys Asp Pro Lys Ile Asp Asn Lys Arg 
465                 470                 475                 480 


Gly Lys Glu Ser Ile Phe Leu Asn Ile Leu Leu Gly Ile Tyr Cys Lys 
                485                 490                 495     


Ser Gly Ile Gln Pro Trp Val Leu Ala Asn Gly Leu Ser Ala Asp Cys 
            500                 505                 510         


Tyr Ile Gly Leu Asp Val Cys Arg Glu Asn Asn Met Ser Thr Ala Gly 
        515                 520                 525             


Leu Ile Gln Val Ile Gly Lys Asp Gly Arg Val Leu Lys Ser Lys Thr 
    530                 535                 540                 


Ile Ser Ser His Gln Ser Gly Glu Lys Ile Gln Ile Asn Ile Leu Lys 
545                 550                 555                 560 


Asp Ile Ile Phe Glu Ala Lys Gln Ala Tyr Lys Asn Thr Tyr Asn Lys 
                565                 570                 575     


Lys Leu Glu His Ile Val Phe His Arg Asp Gly Ile Asn Arg Glu Asp 
            580                 585                 590         


Ile Asp Leu Leu Lys Glu Ile Thr Asn Ser Leu Glu Ile Lys Phe Asp 
        595                 600                 605             


Tyr Val Glu Val Thr Lys Asn Ile Asn Arg Arg Met Ala Met Leu Glu 
    610                 615                 620                 


Lys Ser Asp Glu Asn Tyr Asn His Arg Asp Lys Glu Asn Lys Lys Trp 
625                 630                 635                 640 


Ile Thr Glu Ile Gly Met Cys Leu Lys Lys Glu Asn Glu Ala Tyr Leu 
                645                 650                 655     


Ile Thr Thr Asn Pro Ser Glu Asn Met Gly Met Ala Arg Pro Leu Arg 
            660                 665                 670         


Ile Lys Lys Val Tyr Gly Asn Gln Asn Met Asp Asp Ile Val Lys Asp 
        675                 680                 685             


Ile Tyr Lys Leu Ser Phe Met His Ile Gly Ser Ile Met Lys Ser Arg 
    690                 695                 700                 


Leu Pro Ile Thr Thr His Tyr Ala Asp Leu Ser Ser Ile Tyr Ser His 
705                 710                 715                 720 


Arg Glu Leu Met Pro Lys Ser Val Asp Asn Asn Ile Leu His Phe Ile 
                725                 730                 735     


<210>  10
<211>  751
<212>  PRT
<213>  Limnothrix sp. P13C2


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A1C0UUC4

<400>  10

Met Asp Ile Arg Glu Leu Ser Phe Gln Ser Arg Lys Pro Leu Gly Ala 
1               5                   10                  15      


Val Pro Ala Arg Arg Asp Arg Leu Arg Ile Val Gly Ser Ala Thr Pro 
            20                  25                  30          


Ile Glu Thr Leu Tyr Ser Leu Ala Arg Phe Cys Lys Phe Arg Leu Asn 
        35                  40                  45              


Gln Trp Val Thr Asn Asp Gln Ser Ser Leu Ala Leu Ile Ser Glu Asp 
    50                  55                  60                  


Arg Gly Gln Ala Ala Asn Leu Leu Ala Cys Leu Arg Gln Phe Cys Glu 
65                  70                  75                  80  


Thr Ser Ser Glu Pro Leu Glu Ile Glu Ile Leu Lys Ser Glu Ala Ile 
                85                  90                  95      


Asp Leu Ser Glu Pro Arg Tyr Gln Asn Trp Leu Phe Gln Leu Cys Asn 
            100                 105                 110         


Tyr Arg Leu Cys Ser Ile Phe Lys Thr Ile Asn Pro His Ser Ala Lys 
        115                 120                 125             


Lys Val Gln Glu Thr Arg Lys Arg Ile Tyr Ser Asn Glu Pro Pro Met 
    130                 135                 140                 


Gln Ile Arg Asp Pro Gln Gly Arg Ile Ile Ala Glu Ala Arg Arg Tyr 
145                 150                 155                 160 


Leu Thr Phe Asp Phe Trp Gln Asn Ser Ala Gly Phe Leu Phe Leu Thr 
                165                 170                 175     


Leu His Phe Arg Asn Glu Tyr Gln Ser Ile Gly Thr Ile Asp Gln Phe 
            180                 185                 190         


Asp Trp Gln Gln Phe Pro Pro Lys Gln Arg Leu Ile His Thr Tyr Asp 
        195                 200                 205             


Gly Lys Ser Cys Gln Phe Leu Gly Val Ala Pro Ile Thr Ile Gly Gln 
    210                 215                 220                 


Pro Leu Ala Glu Leu Gly Asn Gln Ser Leu Leu Asn Tyr His Cys Asp 
225                 230                 235                 240 


Arg Gln Asn Leu Pro Pro Glu Leu Ala Ala Gln Leu Asp Pro Asn Gln 
                245                 250                 255     


Pro Ala Val Ala Val Gly Tyr Pro Pro Arg Tyr Gln Pro Phe His His 
            260                 265                 270         


Leu Pro Gln Leu Leu Lys Arg Ile Tyr Ala Arg Glu Asp Leu Pro Ser 
        275                 280                 285             


Lys Ser Leu Asn His Cys Ile Leu Pro Leu Ala Lys Arg Arg Glu Leu 
    290                 295                 300                 


Met Gln Lys Thr Ile Asp Leu Leu Asn Lys Arg Glu Phe Ile Cys Gly 
305                 310                 315                 320 


Asp Arg Ile Glu Phe Asp Pro Asn Pro Trp Gln Pro Asp Arg Leu Thr 
                325                 330                 335     


Gln Leu Thr Ala Gly Ser Met Ala Arg Asn Leu Ser Phe Gly Ala Asp 
            340                 345                 350         


Pro Gln Gln Pro Asp Arg Pro Ile Leu Val Asp Glu Ala Trp Arg Gly 
        355                 360                 365             


Trp Lys Gln Arg Thr Leu His Gln Lys Pro Ala Glu Ile Arg Thr Gln 
    370                 375                 380                 


Val Leu Tyr Pro Gln Ala Trp Glu Ala Glu Val Lys Lys Tyr Met Ser 
385                 390                 395                 400 


Ala Leu Lys Ser Arg Phe Gln Glu Phe Gly Ile Thr Leu Thr Arg Ala 
                405                 410                 415     


Gly Asp Leu Arg Pro Tyr Asp Pro Gln Asn Ser Leu Ser Leu Arg Gln 
            420                 425                 430         


Val Cys Gln Asn Leu Pro Val Asn Ala Asn Asp Leu Ile Phe Ala Phe 
        435                 440                 445             


Val Pro Asn Gly Ala Asp Pro Ile Tyr Asn Ala Gln Val Asn Pro Tyr 
    450                 455                 460                 


Phe Thr Leu Lys Arg Ile Leu Asn Gln Gln Ser Tyr Cys Ser Gln Met 
465                 470                 475                 480 


Val Thr Arg Glu Thr Met Arg Gln Ile Asn Asn Asp Gly Arg Asp Gln 
                485                 490                 495     


Asn Val Val Phe Gly Ile Leu Ala Lys Leu Gly Tyr Ala Pro Trp Gln 
            500                 505                 510         


Leu His Gln Met Pro Gly Thr Ala Gln Ala Phe Val Gly Leu Asp Leu 
        515                 520                 525             


Gly Arg Lys Glu Glu Arg Thr Ile Gly Ala Ser Ala Phe Val Val Asn 
    530                 535                 540                 


Arg Gln Gly Gln Ala Ile Gly Trp Ser Ser Ala Ser Met Gln Arg Gly 
545                 550                 555                 560 


Glu Thr Phe Ser Glu Thr Ser Leu Arg Asn Ile Leu Leu Asp Leu Phe 
                565                 570                 575     


Gly Ala Phe Thr Glu Gln Ser Gly Glu Pro Leu Arg His Val Val Ile 
            580                 585                 590         


His Arg Asp Gly Thr Val Lys Asn Ser Glu Leu Ala Thr Leu Gln Ala 
        595                 600                 605             


Leu Glu Ala Glu Leu Arg Pro His Gly Leu Glu Gln Leu Glu Val Val 
    610                 615                 620                 


Glu Val Val Lys Asp Val Leu Ala Arg Ala Ala Val Arg Ala Ile Asp 
625                 630                 635                 640 


Pro Asn Thr Asn Gln Glu Gln Trp Gln Asn Pro Asp Arg Gly Trp Ala 
                645                 650                 655     


Trp Val His Asn Asp His Glu Ala Ile Val Leu Thr Thr Gly Ala Lys 
            660                 665                 670         


Gln Ala Lys Val Ala Pro Asn Ala Ser Pro Gln Pro Leu Leu Val Arg 
        675                 680                 685             


Arg Arg His Gly Gln Thr Asp Ile Leu Thr Ile Ala Ala Gln Ile Tyr 
    690                 695                 700                 


Trp Leu Ser Glu Met His Ile Gly Ser Thr Gln Val Ile Arg Leu Pro 
705                 710                 715                 720 


Ile Thr Thr Tyr Tyr Ala Asp Arg Ile Ala Glu Val Ala Leu Lys Asp 
                725                 730                 735     


Cys Leu Pro Ala Asp Val Arg Cys Glu Arg Arg Leu Tyr Phe Val 
            740                 745                 750     


<210>  11
<211>  714
<212>  PRT
<213>  Lyngbya confervoides BDU141951


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A0C1VHB4

<400>  11

Met Asn Gln Arg Pro Glu Val Tyr Leu Asn Arg Phe Pro Val Arg Ser 
1               5                   10                  15      


Leu Asp Glu Asp Asp Leu Arg Val Phe Arg Tyr Arg Tyr Phe Phe Glu 
            20                  25                  30          


Glu Ser Pro Glu Asn Ser Asp Ile Tyr Lys Ala Val Gly Arg Ile Leu 
        35                  40                  45              


Tyr Gln Ile Gly Tyr Val Ala Gly Ala Arg Leu Asp Ser Gly Ile Ile 
    50                  55                  60                  


Thr Ser Ala Pro Ile Glu Glu Asp Arg Leu Gln Gly Glu Gly Trp His 
65                  70                  75                  80  


Leu Gln Phe Val Asp Glu Met Gln Leu Lys Pro Glu Ser Ser Val Glu 
                85                  90                  95      


Arg Lys Ala Leu Glu Gln Ile Phe Arg Lys His Leu Arg Gln Glu Leu 
            100                 105                 110         


Gln Lys Ile Lys Gly Gln Lys Val Glu Arg Ala Gly Glu Gly Leu Val 
        115                 120                 125             


Trp Trp Asp Glu Ser Lys Ile Glu Ser Ser Gly Asp Gly Trp Gln Val 
    130                 135                 140                 


Leu Lys Gly Ala Leu Val Asp Val Ala Ile Asp Glu Asn Gly Gln Leu 
145                 150                 155                 160 


Asn Leu Glu Ile Asp Thr His Tyr Arg Phe Tyr Ser Pro Trp Thr Leu 
                165                 170                 175     


His Gln Trp Leu Thr Arg Tyr Pro Asp Val Pro Val Asn Phe Val Arg 
            180                 185                 190         


Asn Val Gly Ser Asp Ile Ser Trp Tyr Phe Leu Glu Gly Ser Glu Glu 
        195                 200                 205             


Arg Pro Glu Asp Ile Asp Ile Lys Asp Leu Gly Ile Thr Leu Ala Asp 
    210                 215                 220                 


Tyr His Arg Asn Lys Gly Val Ser Glu Gln Ile Ile Gln Asp Ser Phe 
225                 230                 235                 240 


Val Val Tyr Val Arg Ser Thr Arg Lys Trp Gly Ala Lys Gln Asp Arg 
                245                 250                 255     


Val Ala His Leu Ser Lys Leu Leu Gln Pro Ser Val Ser Met Glu Val 
            260                 265                 270         


Leu Ser Tyr Val Ala Glu Gln Gly Asp Arg Asp Ala Glu Asn Val Leu 
        275                 280                 285             


Thr Gly Val Arg Lys Ser Ile Asn Glu Arg Leu Ser Lys Gly Gln Gly 
    290                 295                 300                 


Ile Ala Lys Phe Ile Ser Lys Lys Ile Tyr Gly Leu Glu Ser Ser Glu 
305                 310                 315                 320 


Val Ser Pro Gln Lys Arg Ile Ala Thr Leu Phe Thr Ser His Ser Leu 
                325                 330                 335     


Ile Ala Arg Asn Glu Ser Glu Val Lys Arg Ala Asn Asp Ala Leu Asn 
            340                 345                 350         


Lys Gly Cys Leu Arg Thr Gly Glu Thr Gln Phe Gly Tyr Leu Asn Leu 
        355                 360                 365             


Leu Gln Glu Asp Asn Asp Trp Pro Glu Ala Val Lys Asn Gln Leu Ser 
    370                 375                 380                 


Lys Val Ala Lys Ala Ser Gly Val Ser Leu Glu Leu Ser His Arg Phe 
385                 390                 395                 400 


His Arg Arg Asp Leu Pro Glu Ser Asp Met Glu Arg Arg Arg Phe Trp 
                405                 410                 415     


Ser Ser Ile Ser Asp Leu Asn Ile Lys Thr Met Leu Val Val Ser Pro 
            420                 425                 430         


Met Leu Gly Asn Ala Arg Lys Ala Gln Phe Arg Arg Glu Ala Leu Gln 
        435                 440                 445             


Ala Gly Ile Ala Leu Gln Phe Met Arg Pro Met Arg Gly Leu Asp Gln 
    450                 455                 460                 


Tyr Arg Ala Ala Asn Val Thr Leu Gly Leu Leu Val Lys Ala Gly Trp 
465                 470                 475                 480 


Gln Pro Ile Gly Met Lys Met Pro Ala Asp Pro Gln Ala Ala Asp Leu 
                485                 490                 495     


Cys Ile Gly Phe Asp Ala Gly Thr Asn Lys Lys Leu Phe Tyr Gly Thr 
            500                 505                 510         


Ser Ala Phe Ala Val Leu Ala Asn Gly Gln Ser Leu Gly Trp Glu Ile 
        515                 520                 525             


Pro Glu Ala Gln Leu Gly Glu Ser Phe Ser Ser Gln Ala Ile Trp Glu 
    530                 535                 540                 


Ala Thr Ser Ser Ile Val Glu Arg Phe Tyr Arg Leu Asn Asn Arg Asn 
545                 550                 555                 560 


Pro Gly Arg Ile Phe Leu Leu Arg Asp Gly Phe Val Arg Asp Gln Glu 
                565                 570                 575     


Phe Asp Tyr Thr Ile Asn Asn Leu Glu Ala Glu Asn Ile Ala Val Asp 
            580                 585                 590         


Leu Leu Glu Val His Lys Ser Gly Ala Gly Arg Met Ala Lys Arg Leu 
        595                 600                 605             


Gln Asn Asp Val Phe His Glu Val Asp Pro Gly Thr Gly Phe Ser Ile 
    610                 615                 620                 


Ala Asp Asp Ala Phe Arg Ile Val Thr Ser Gln Ala His Ala Gly Gly 
625                 630                 635                 640 


Ser Ala Arg Pro Leu Glu Val Val Lys Ile His Gly Asp Ala Ser Leu 
                645                 650                 655     


Arg Leu Leu Ala Asn Glu Ile Phe Ala Leu Ser Gln Phe His Pro Ala 
            660                 665                 670         


Ser Ala Phe Arg Ser Ser Arg Leu Pro Met Pro Leu His Tyr Ala Asp 
        675                 680                 685             


Arg Met Ile Lys Glu Val Gln Arg Leu Gly Gln Leu Ser Ile Leu His 
    690                 695                 700                 


Gly Ile Asp Arg Gln Lys Leu Phe Phe Ala 
705                 710                 


<210>  12
<211>  764
<212>  PRT
<213>  Lyngbya sp. (strain PCC 8106) (Lyngbya aestuarii (strain CCY9616))


<220>
<221>  misc_feature
<223>  UniProt ID No: A0YYT3

<400>  12

Met Asn Thr Thr Ser Gln Ala Pro Gln Asn Ser Thr Ser Ser Ser Ile 
1               5                   10                  15      


Tyr Leu Ser Glu Ile Phe Pro Leu Thr Ile Leu Lys Pro Asn Leu Ile 
            20                  25                  30          


Cys Phe Arg Leu Thr Pro Glu Val Asp Arg Glu Val Gly Asn Arg Leu 
        35                  40                  45              


Ser Trp Arg Phe Ser Gln Lys Phe Ala Glu Ile Val Val Ile Trp Glu 
    50                  55                  60                  


Asn Lys Tyr Phe Trp Val Leu Ala Lys Pro Thr Gln Lys Met Pro Ser 
65                  70                  75                  80  


Pro Glu Gln Trp Arg Gln Ala Leu Gly Glu Ile Leu Glu Gln Leu Lys 
                85                  90                  95      


Glu Asp Ile Gly Asp His Tyr Tyr Ser Ile Gln Trp Val Arg Asp Pro 
            100                 105                 110         


Gln Val Thr Ala Ser Thr Leu Ala Gln Leu Ala Val Arg Val Leu Lys 
        115                 120                 125             


Ile Arg Lys Pro Phe Ser Pro Asp Ile Ile Phe Ser Glu Asn Gln Val 
    130                 135                 140                 


Gln Val Gln Ser Glu Val Asp Phe Trp Pro Glu Thr Ile Glu Leu Ala 
145                 150                 155                 160 


Asn Thr Leu Thr Pro Ala Ile Thr Leu Thr Leu Lys Ser Arg Phe Leu 
                165                 170                 175     


Tyr Arg Gly Thr Leu Ala Glu Phe Tyr Ala Asn His Pro Tyr Arg Asn 
            180                 185                 190         


Lys Pro Lys Glu Leu Leu Val Gly Leu Lys Val Arg Asp Arg Glu Thr 
        195                 200                 205             


Asn Ser Ser Ala Thr Ile Val Glu Ile Ala Ala Ile Asp Glu Asp Arg 
    210                 215                 220                 


Arg Lys Glu Leu Ile Glu Lys Ala Thr Gly Ala Val Ser Arg Gln Ala 
225                 230                 235                 240 


Leu Glu Glu Ala Pro Asp Asp Gln Pro Leu Val Ser Val Arg Phe Gly 
                245                 250                 255     


Lys Asn Gln Lys Leu Phe Asp Tyr Pro Met Glu Ala Leu Cys Pro Ser 
            260                 265                 270         


Ile Thr Lys Glu Thr Ala Ser Lys Phe Asp Val Asn Tyr Gly Asp Leu 
        275                 280                 285             


Ile Lys Gln Thr Lys Pro Pro Tyr Gln Glu Arg Gln Asn His Leu Thr 
    290                 295                 300                 


Gln Ser Lys Gln Lys Ala Glu Glu Ser Leu Ala Val Tyr Gly Phe Gln 
305                 310                 315                 320 


Ile Asp Lys Ser Ile Asn Asn Leu Asp Tyr Pro Ser Leu Phe Gln Thr 
                325                 330                 335     


Leu Gln Phe Asn Leu Glu Asp Thr Glu Leu Leu Phe Gly Lys Asp Ser 
            340                 345                 350         


Ser Gly Lys His Phe Val Ser Lys Arg Gly Ser Val Leu Lys Gly Leu 
        355                 360                 365             


Ser Gln Gly Gly Val Tyr Arg Arg His Gln Asp Tyr Glu Asn Tyr Ser 
    370                 375                 380                 


Thr Pro Ile Arg Ile Ser Leu Leu Asn Leu Cys Asn Ser Lys Val Gly 
385                 390                 395                 400 


Lys Phe Val Ser Gln Val Glu Glu Arg Leu Lys Gln Tyr Lys Phe Glu 
                405                 410                 415     


Thr Ile Arg Phe Glu Lys Asp Ser Leu Asp Arg Arg Lys Glu Ile Lys 
            420                 425                 430         


Val Asp Asn Leu Asp Ser Ala Glu Ala Arg Val Ala Val Glu Lys Ala 
        435                 440                 445             


Leu Asp Glu Leu Met Val Ile Pro Thr Asn Ile Val Leu Thr Phe Leu 
    450                 455                 460                 


Pro Glu Ser Asp Arg His Thr Asp Asp Thr Glu Asp Gly Ser Phe Tyr 
465                 470                 475                 480 


Ser Phe Val Ser Ser Arg Leu Leu Arg Arg Gly Ile Ser Ser Gln Val 
                485                 490                 495     


Ile Tyr Glu Asp Thr Leu Lys Asn Pro Asn Asn Tyr Ser Tyr Ile Leu 
            500                 505                 510         


Asn Gln Val Ile Pro Gly Ile Leu Ala Lys Leu Gly Asn Leu Pro Phe 
        515                 520                 525             


Ile Leu Ala Lys Pro Leu Glu Ile Ala Asp Tyr Phe Ile Gly Leu Asp 
    530                 535                 540                 


Ile Ser Arg Thr Pro Lys Lys Arg Lys Ser Gly Ser Leu Asn Val Cys 
545                 550                 555                 560 


Ala Ser Val Arg Leu Tyr Gly Lys Tyr Gly Glu Phe Ile Arg Tyr Arg 
                565                 570                 575     


Leu Glu Asp Ala Leu Thr Gln Gly Glu Glu Ile Asp Lys Arg Thr Leu 
            580                 585                 590         


Glu Arg Phe Leu Pro Ala Ala Asp Leu Ser Gly Lys Thr Val Leu Ile 
        595                 600                 605             


Tyr Arg Asp Gly Arg Phe Cys Gly Asp Glu Ile Lys His Leu Arg Glu 
    610                 615                 620                 


Arg Ala Lys Ala Met Gly Ser Lys Phe Ile Leu Val Glu Cys Ile Lys 
625                 630                 635                 640 


Ser Gly Ile Pro Arg Leu Tyr Glu Val Gln Glu Leu Thr Val Lys Asp 
                645                 650                 655     


Lys Lys Lys Pro Ile Leu Lys Ala Pro Pro Lys Gly Leu Ala Leu Arg 
            660                 665                 670         


Leu Ser Ser His Glu Val Met Leu Val Thr Thr Glu Val Lys Ser Glu 
        675                 680                 685             


Lys Met Gly Leu Pro Asn Pro Leu Arg Leu Lys Val Ile Pro Glu Glu 
    690                 695                 700                 


Gly Gln Gln Val Ser Leu Glu Ser Leu Val Glu Ala Thr Leu Lys Leu 
705                 710                 715                 720 


Thr Leu Leu His His Gly Ser Leu Lys Glu Pro Arg Leu Pro Ile Pro 
                725                 730                 735     


Leu Tyr Gly Ser Asp Ile Ile Ala Tyr Arg Arg Leu Gln Gly Ile Ser 
            740                 745                 750         


Pro Gly Glu Leu Asp Gly Asp Arg Gln Phe Trp Leu 
        755                 760                 


<210>  13
<211>  568
<212>  PRT
<213>  Marinobacter sp. T13-3


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A139DLI2

<400>  13

Leu Gly Leu Ser Val Arg His Lys Ile Cys Ala Lys Asp Gly Ile Thr 
1               5                   10                  15      


Leu Asp Trp Val Ile Asn Asn Arg Pro Asp Trp Leu Lys Asp Ile Arg 
            20                  25                  30          


Arg Val Arg His Cys Tyr Val Ala Gln Gly Lys Pro Pro Gly Val Ala 
        35                  40                  45              


Asp Phe His Gly Leu Ala Asn Asp Lys Thr Ala Asp Ser Ala Val Pro 
    50                  55                  60                  


Gly Thr Pro His Thr Leu Tyr Ser Tyr His Glu Glu Lys Gly His Ile 
65                  70                  75                  80  


Arg Pro Gly Gln Ala Glu Ser Val His Thr Ser His Val Val Lys Val 
                85                  90                  95      


Ser Tyr Gly Arg Lys Asp Thr Phe Asp His Leu Gly Ala Leu Leu Glu 
            100                 105                 110         


Pro Met Phe Asp Phe Glu Thr Leu Gln Lys Ile Asp Ser Pro Leu Leu 
        115                 120                 125             


Asn Arg Met Ala Arg Asp Leu Lys Trp Pro Ile Met Asp Arg Leu Lys 
    130                 135                 140                 


Ala Ser Gly Ala Met Met Arg Gly Leu Val Leu Pro Gly Phe Lys Ala 
145                 150                 155                 160 


Arg Val Val Pro Leu Glu Pro Leu Leu Glu Ala Ala Asp Asn Ile Cys 
                165                 170                 175     


Pro Pro Phe Arg Leu Asn Phe Tyr Asn Gly Arg Thr Ala Asp Thr Glu 
            180                 185                 190         


Lys Ala Val Leu Lys Leu Gly Ala Phe Arg Gly Met Thr Arg Ser Gln 
        195                 200                 205             


Val Val Cys Leu Ala Val Gly Thr Ser Val Ser Ser Asp Asp Leu Ser 
    210                 215                 220                 


Asp His Phe His Lys Leu Arg Glu Ala Cys Gln Ser Leu Ser Ala Asp 
225                 230                 235                 240 


Pro Leu Pro Lys Trp Arg Gly Leu Leu Glu Pro Lys Pro Leu Lys His 
                245                 250                 255     


Ala Met Glu Leu Asp Lys Arg Leu Val Glu Thr Pro Pro Glu Asn Thr 
            260                 265                 270         


Leu Leu Val Ile Ala Ile Asp Lys Ser Val Asn Lys Ala Glu Ile Arg 
        275                 280                 285             


Asp Val Ala Phe Arg His Lys Leu Ala Cys Gln Phe Met Leu Val Asp 
    290                 295                 300                 


His Asn Ser Lys Thr Tyr Gln Arg Thr Tyr Tyr Asn Asn Leu Ala Ala 
305                 310                 315                 320 


Gly Val Phe Ser Lys Gly Gly Gly Leu Ile Cys Gly Leu Gly Asp Met 
                325                 330                 335     


Pro Gly Glu Val Asp Leu Phe Ile Gly Leu Asp Leu Gly Gly Val Ser 
            340                 345                 350         


Gln Arg Ala Pro Gly Ser Ala Phe Leu Phe Thr Arg Asn Gly Ala Gln 
        355                 360                 365             


Leu Gly Trp Gln Leu Ala Asp Leu Gln Ser Gly Glu Arg Leu Glu Asp 
    370                 375                 380                 


Lys Ala Leu Lys Ser Leu Leu His Lys Ser Ile Gln Glu Tyr Gly Arg 
385                 390                 395                 400 


His His Asn Gly Glu Pro Pro Arg Thr Met Thr Ile His Arg Asp Gly 
                405                 410                 415     


Arg Phe Phe Glu Ser Leu Asp Val Ile Ala Glu Val Glu Lys Gln Tyr 
            420                 425                 430         


Asp Met Lys Ile Ser Val Leu Glu Val Ile Lys Ser Gly Ala Pro Ile 
        435                 440                 445             


Leu Phe Arg Lys Tyr Gln Leu Ser Arg Lys Ser Glu Tyr Arg Asn Pro 
    450                 455                 460                 


Glu Val Gly Asp Val Tyr Arg Tyr Val Gly Leu Asp Glu Leu Ile Leu 
465                 470                 475                 480 


Ala Thr Tyr Ser Gly Gln Glu Leu Gly Ala Trp Gly Asp Lys Val Ser 
                485                 490                 495     


Val Arg Pro Leu Arg Leu Arg Lys Arg Tyr Gly Glu Gln Ser Leu Asp 
            500                 505                 510         


Val Met Ala Gln Gln Val Leu Leu Leu Ser Arg Ile His Gly Ala Ser 
        515                 520                 525             


Leu Tyr Arg His Pro Arg Leu Pro Val Thr Thr His His Ala Asp Arg 
    530                 535                 540                 


Phe Ala Ser Leu Arg Gln Ser Cys Ser Leu Glu Ala Leu Ser His Met 
545                 550                 555                 560 


Asp Arg Thr Cys Pro Val Tyr Leu 
                565             


<210>  14
<211>  760
<212>  PRT
<213>  Methylomonas koyamae


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A177NTC0

<400>  14

Met Leu Lys Lys Glu Leu Tyr Glu Gln Leu Val Asp Ala Ala Asn Ile 
1               5                   10                  15      


Ile Gln Arg Gln Phe Met Glu Asn Leu Ala Leu Ser Ala Leu Gln Leu 
            20                  25                  30          


Glu Ala Asn Leu Ile His Tyr Ser Val Cys His Tyr Gln Ile Val Tyr 
        35                  40                  45              


Gln Lys Phe Asp Glu Thr Ala Ser Gly Glu Gln Leu Ala Arg Lys Val 
    50                  55                  60                  


Ala Tyr Glu Leu Gln Arg Val Asn Gly Phe Ala Val Leu Thr Asn Leu 
65                  70                  75                  80  


Gly Ser Arg Arg Ile Ile Ser Leu Lys Pro Ile Ser Gln Leu Thr Ile 
                85                  90                  95      


Asp Leu Pro Gln Leu Gln Ala Asn Leu Gln Asp Tyr Gly Lys Leu Glu 
            100                 105                 110         


Leu Asp Cys Gly Glu Glu Gln Gln Gln Gln Ala Leu Gln Arg Leu Val 
        115                 120                 125             


Asn Gln Asp Ile Asn Lys Ala Ala Trp Lys Leu Thr Gln Glu Ser Gln 
    130                 135                 140                 


Gly Lys Leu Ala Ser Lys Lys Ala Ala Ser Gly Asn Thr Glu Ile Phe 
145                 150                 155                 160 


Glu Ser Ser Pro Ser Thr Arg Ile Asn Ala Arg Ala Thr Tyr Leu Asp 
                165                 170                 175     


Ala Phe Cys Ser Val Gln Leu Ser Pro Glu Val Leu Ala Asp Gly Thr 
            180                 185                 190         


Val Leu Ile Gly Leu His Leu Lys His Ser Leu Val Ala Lys Ser Asn 
        195                 200                 205             


Ile Ser Leu Gln Trp Ile Ile Asp Lys Arg Pro Asp Trp Ile Pro Ser 
    210                 215                 220                 


Ile Lys Lys Val Arg His Arg Tyr Phe Glu Ser Gly Lys Ala Pro Leu 
225                 230                 235                 240 


Val Ala Glu Phe Leu Arg Val Glu Asp Ser Leu Asn Gly Asn Ser Arg 
                245                 250                 255     


Leu Pro His Leu Gly Lys Ser Leu Val Asp Tyr His Gln Glu Lys Gly 
            260                 265                 270         


Leu Leu Ser Ser Gln Gln Leu Thr Glu Ala Ala Thr Ser Ser Leu Ile 
        275                 280                 285             


Lys Val Lys Tyr Gly Gln Asn Glu Ala Asp His Val Ala Ser Leu Val 
    290                 295                 300                 


Glu Pro Met Phe Asp Phe Asp Thr Leu Ser Lys Ile Asp Ser Val Phe 
305                 310                 315                 320 


Leu Asn Asn Leu Ala Lys Asp Leu Lys Trp Ser Leu Asp Asp Arg Ile 
                325                 330                 335     


Lys Val Ser Ala Lys Met Val Lys Gly Leu Tyr Leu Pro Asn Phe Asn 
            340                 345                 350         


Tyr Arg Leu Met Pro Val Asp Tyr Gln Asn Leu Lys Lys Ser Cys Leu 
        355                 360                 365             


Gln Tyr Glu Arg Met Leu Arg Phe Ala Asn Gly Ala Lys Ser Asn Arg 
    370                 375                 380                 


Glu Gln Asp Val Leu Lys Tyr Lys Ala Phe Gly Asp Met Thr Arg Thr 
385                 390                 395                 400 


Gln Val Ile Pro Leu Ile Ile Gly Lys Gln Asn Asn Thr Glu Arg Asn 
                405                 410                 415     


Gln Arg Leu Leu Ser Glu Val Tyr Lys Ser Leu Gly Gln Leu Thr Lys 
            420                 425                 430         


Ala Thr Leu Pro Pro Leu Thr Lys Phe Pro Asp Pro Val Glu Asn Ala 
        435                 440                 445             


Ser Glu Leu Asp Ala Arg Leu Asn Arg Lys Ser Pro Ala Asn Ala Ile 
    450                 455                 460                 


Leu Leu Ile Gly Leu Thr Asp Lys Ser Asp Lys Val Ala Ile Arg Asp 
465                 470                 475                 480 


Thr Ala Phe Ser Tyr Gly Leu Ala Thr Gln Phe Met Arg Leu Asp His 
                485                 490                 495     


His Ser Gly Ile Tyr Ser Ala Ser Tyr Phe Asn Asn Val Ala Ala Gly 
            500                 505                 510         


Val Phe Ser Lys Gly Gly Gly Gln Leu Cys Ser Ile Asn Asp Met Pro 
        515                 520                 525             


Gly Glu Thr Asp Leu Phe Ile Gly Leu Asp Met Gly Gly Val Asn Val 
    530                 535                 540                 


Arg Ala Pro Gly Phe Ala Phe Leu Phe Leu Ser Ser Gly Thr Gln Leu 
545                 550                 555                 560 


Gly Trp Gln Leu Ala Asp Lys Gln Gln Gly Glu Arg Met Gln Asp Glu 
                565                 570                 575     


Ala Leu Met Asn Leu Leu Glu Lys Ser Leu Lys Thr Tyr Leu Arg Ser 
            580                 585                 590         


Ser Asp Gly Val Leu Pro Arg Arg Ile Thr Leu His Arg Asp Gly Lys 
        595                 600                 605             


Phe Tyr Glu Ser Ile Asp Val Ile Glu Gln Phe Ser Lys Asn His Thr 
    610                 615                 620                 


Val Lys Ile Asp Val Leu Glu Val Leu Lys Ser Gly Ala Pro Val Leu 
625                 630                 635                 640 


Tyr Arg Arg Glu Gln Ser Ala Asp Gly Thr Lys Lys Phe Ile Asn Pro 
                645                 650                 655     


Asn Ala Gly Asp Ala Leu Tyr Leu Ser Asp Arg Glu Ile Ile Leu Ser 
            660                 665                 670         


Thr Tyr Ser Gly Ala Glu Leu Gly Lys Ser Trp Gly Asp Lys Val Ser 
        675                 680                 685             


Val Arg Pro Leu Arg Leu Arg Lys Arg Tyr Gly Glu Thr Ser Leu Glu 
    690                 695                 700                 


Val Leu Ala Gln Gln Val Leu Ile Leu Ser Arg Ile His Gly Ala Ser 
705                 710                 715                 720 


Leu Tyr Arg His Pro Arg Leu Pro Val Thr Thr His His Ala Asp Arg 
                725                 730                 735     


Phe Ala Thr Leu Arg Gln Glu Thr Cys Ile Asp Ala Leu Ser Lys Met 
            740                 745                 750         


Asp Arg Leu Cys Pro Val Tyr Leu 
        755                 760 


<210>  15
<211>  705
<212>  PRT
<213>  Paenibacillus borealis


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A089L658

<400>  15

Met Asn Thr Pro Leu Thr His Tyr Val Leu Thr Glu Trp Glu Ser Asp 
1               5                   10                  15      


Thr Asn Thr Asn Val Leu His Ile His Leu Tyr Thr Leu Pro Val Arg 
            20                  25                  30          


Asn Val Phe Glu Gln His Lys Glu Asn Gly Asn Ala Cys Phe Asp Leu 
        35                  40                  45              


Arg Lys Leu Asn Arg Ser Leu Ile Ile Asp Phe Tyr Asp Gln Tyr Ile 
    50                  55                  60                  


Val Ser Trp Gln Pro Ile Glu Asn Trp Gly Glu Tyr Thr Phe Thr Gln 
65                  70                  75                  80  


His Glu Tyr Arg Ser Ile Asn Pro Thr Ile Leu Ala Glu Arg Ala Ile 
                85                  90                  95      


Leu Glu Arg Leu Leu Leu Arg Thr Ile Glu Ser Val Gln Pro Lys Lys 
            100                 105                 110         


Glu Ile Ala Ala Gly Ser Arg Lys Phe Thr Trp Leu Lys Ala Glu Lys 
        115                 120                 125             


Val Val Glu Asn Ile Ser Ile His Arg Val Ile Gln Cys Asp Val Thr 
    130                 135                 140                 


Val Asp Tyr Ala Gly Lys Ile Ser Val Gly Phe Asp Leu Asn His Ser 
145                 150                 155                 160 


Tyr Arg Thr Asn Glu Ser Val Tyr Asp Leu Met Lys Ser Asn Ala Ile 
                165                 170                 175     


Phe Lys Gly Asp Arg Val Ile Asp Ile Tyr Asn Asn Leu His Tyr Glu 
            180                 185                 190         


Phe Val Glu Ile Ser Asn Ser Thr Ile Asn Asp Ser Ile Pro Glu Leu 
        195                 200                 205             


Asn Gln Ser Val Val Asn Tyr Phe Thr Lys Glu Arg Lys Gln Ala Trp 
    210                 215                 220                 


Lys Val Asp Lys Leu Glu Gln Ser Met Pro Val Val Tyr Leu Lys Ala 
225                 230                 235                 240 


Phe Asn Gly Ser Arg Ile Ala Tyr Ala Pro Ala Met Leu Gln Lys Glu 
                245                 250                 255     


Leu Thr Phe Glu Ser Leu Pro Thr Asn Val Val Arg Gln Thr Ser Glu 
            260                 265                 270         


Ile Phe Lys Gln Asn Ala Asn Gln Lys Ile Lys Thr Leu Leu Asp Glu 
        275                 280                 285             


Ile Gln Lys Ile Leu Ala Arg Thr Asp Lys Ile Lys Phe Asn Lys Gln 
    290                 295                 300                 


Lys Leu Leu Val Gln Gln Ala Gly Tyr Glu Ile Leu Glu Leu Ser Asn 
305                 310                 315                 320 


Pro Asn Leu Gln Phe Gly Lys Asn Val Thr Gln Thr Gln Leu Lys Tyr 
                325                 330                 335     


Gly Leu Asp Lys Gly Gly Val Val Ala Ser Lys Pro Leu Ser Ile Asn 
            340                 345                 350         


Leu Leu Val Tyr Pro Glu Leu Ile Asp Thr Lys Leu Asp Val Ile Asn 
        355                 360                 365             


Asp Phe Asn Asp Lys Leu Asn Ala Leu Ser His Lys Trp Gly Val Pro 
    370                 375                 380                 


Leu Ser Ile Leu Lys Lys Ser Gly Ala Tyr Arg Asn Arg Pro Ile Asp 
385                 390                 395                 400 


Phe Thr Asn Pro His Gln Leu Ala Ile Leu Leu Lys Glu Leu Thr Lys 
                405                 410                 415     


Asn Leu Phe Gln Glu Leu Thr Leu Val Ile Ile Pro Glu Lys Ile Ser 
            420                 425                 430         


Gly Met Trp Tyr Asp Leu Val Lys Lys Glu Phe Gly Gly Asn Ser Ser 
        435                 440                 445             


Val Pro Thr Gln Phe Ile Thr Ile Glu Thr Leu Gln Lys Ala Asn Asp 
    450                 455                 460                 


Tyr Ile Leu Gly Asn Leu Leu Leu Gly Leu Tyr Ser Lys Ser Gly Ile 
465                 470                 475                 480 


Gln Pro Trp Ile Leu Asn Ser Pro Leu Ser Ser Asp Cys Phe Ile Gly 
                485                 490                 495     


Leu Asp Val Ser His Glu Ala Gly Arg His Ser Thr Gly Ile Val Gln 
            500                 505                 510         


Val Val Gly Lys Asp Gly Arg Val Leu Ser Ser Lys Ala Asn Thr Ser 
        515                 520                 525             


Asn Glu Ala Gly Glu Lys Ile Arg His Glu Thr Met Cys Gln Ile Val 
    530                 535                 540                 


Tyr Ser Ala Ile Asp Gln Tyr Gln Gln His Tyr Asn Glu Arg Pro Lys 
545                 550                 555                 560 


His Val Thr Phe His Arg Asp Gly Phe Cys Arg Glu Asp Leu Leu Ser 
                565                 570                 575     


Leu Asp Glu Val Met Asn Ser Leu Asp Val Gln Tyr Asp Met Val Glu 
            580                 585                 590         


Ile Ile Lys Lys Thr Asn Arg Arg Met Ala Leu Thr Val Gly Lys Gln 
        595                 600                 605             


Gly Trp Glu Thr Lys Pro Gly Leu Cys Tyr Leu Lys Asp Glu Ser Ala 
    610                 615                 620                 


Tyr Leu Ile Ala Thr Asn Pro His Pro Arg Val Gly Thr Ala Gln Pro 
625                 630                 635                 640 


Ile Lys Ile Ile Lys Lys Lys Gly Ser Leu Pro Ile Glu Ala Ile Ile 
                645                 650                 655     


Gln Asp Ile Tyr His Leu Ser Phe Met His Ile Gly Ser Leu Leu Lys 
            660                 665                 670         


Cys Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp Leu Ser Ser Thr Phe 
        675                 680                 685             


Phe Asn Arg Gln Trp Leu Pro Ile Asp Ser Gly Glu Ala Leu His Phe 
    690                 695                 700                 


Val 
705 


<210>  16
<211>  676
<212>  PRT
<213>  Planococcus maritimus


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A150W6E9

<400>  16

Met Ala Ile Ala Glu Ile Lys Asp Met Ala Gly Tyr Glu Ala Lys Ser 
1               5                   10                  15      


Tyr Asp Tyr Arg Ile Ile Asp Glu His Ser Asn Phe Glu Cys Gly Leu 
            20                  25                  30          


Leu Glu Gln Leu Ile Lys Ala Ser Leu Leu Lys Ala Gly Thr His Arg 
        35                  40                  45              


Leu Asp Leu Lys Gln Val Gly Tyr Asp Leu Gln Lys Lys Gln Gly Glu 
    50                  55                  60                  


Lys Ala Gly Glu Val Leu Val Tyr Pro Ala Leu Ser Ile His Val Asn 
65                  70                  75                  80  


Ile Ile Asp Asn Lys Ile His Ile Gly Phe Asn Leu Thr His Lys Phe 
                85                  90                  95      


Glu Tyr Thr Ile Thr Leu Gln Gln Met Ile Glu Arg Asn Gly Val Ile 
            100                 105                 110         


Lys Asp Gln Leu Glu Leu Val Asp Thr Ser Asn Pro Tyr Ser Asn Tyr 
        115                 120                 125             


Thr Tyr Phe Phe Asp His Leu Ala Asp Tyr Gly Val Tyr Asp Asn Ser 
    130                 135                 140                 


Pro Leu Met Asn Gln Ser Ile Val Glu Tyr Phe Asn Gln Lys Gly Gln 
145                 150                 155                 160 


Lys Phe Lys Ile Gly Leu Leu Ser Lys Ser Thr Lys Val Ala His Val 
                165                 170                 175     


Lys Thr Arg Asp Gly Lys Leu Ile Val Met Ala Ala Gln Phe Leu Lys 
            180                 185                 190         


Pro Val Cys Ser Tyr Lys Ser Met Lys Ala Asn Glu Ile Ser Ala Val 
        195                 200                 205             


Asn Lys Val Ile Arg Leu Lys Pro Leu Phe Arg Met Lys Gln Thr Met 
    210                 215                 220                 


Glu Asp Ser Leu Asp Ile Leu Asn Ser Val Lys Tyr Leu Thr Phe Ser 
225                 230                 235                 240 


Pro Glu Pro Phe Leu Ala Lys Asn Asn Gly Tyr Glu Ile Lys Lys Leu 
                245                 250                 255     


Glu Asp Ser Thr Val Leu Phe Asp Lys Pro Gln Lys Trp Pro Val Tyr 
            260                 265                 270         


Gly Leu Lys Asn Gly Lys Ile Tyr Lys Gly Gly Glu Met Thr Val Ser 
        275                 280                 285             


Leu Phe Val Asp Glu Thr Thr Leu Asn Glu Ser Ile Asp Lys Val Phe 
    290                 295                 300                 


Val Tyr Lys Tyr Phe Cys Ile Leu Arg Glu Ile Ala Arg Lys His Gly 
305                 310                 315                 320 


Val Lys Ile Asp Ile Ser Asn Gln Thr Arg Ser Ile Ser Gly Lys Leu 
                325                 330                 335     


Asn Gln Glu Phe Phe Lys Asn Phe Asp Trp Gln Ile Lys Glu His Glu 
            340                 345                 350         


Ala Val Phe Lys Asn Thr Thr Val Leu Ala Val Leu Ser Val Pro His 
        355                 360                 365             


Leu Glu Leu Tyr Glu Pro Phe Lys Lys Gln Phe Gly Gly Asn Trp Asp 
    370                 375                 380                 


Ile Ser Ser Gln Val Ile Ser Val Glu Arg Leu Lys Glu Phe Gln Lys 
385                 390                 395                 400 


Met Leu Ser Ser Asn Lys Glu Leu Ser Phe Asn Pro Lys Asp Asp Glu 
                405                 410                 415     


Ala Val Lys Arg Ile Ala Leu Ser Val Gln Asn Asp Arg Asn Leu Ser 
            420                 425                 430         


Tyr Thr Phe Tyr Asn Ile Leu Leu Gly Leu Tyr Val Lys Ser Gly Met 
        435                 440                 445             


Gln Pro Trp Val Leu Asn Lys Lys Thr Asn Ser Asp Cys Phe Ile Gly 
    450                 455                 460                 


Leu Asp Val Ser His Glu Lys Gly Arg Ser Thr Ala Gly Ile Ile Asn 
465                 470                 475                 480 


Val Ile Gly Asn Asp Gly Arg Leu Ile Lys Gln Ser Ala Val Gly Gly 
                485                 490                 495     


Ala Asn Ala Gly Glu Lys Val Ser Asp Glu Leu Leu Lys Asp Thr Leu 
            500                 505                 510         


Asn Glu Val Leu His Lys Tyr Lys Val Gln Phe Asp Glu Leu Pro Lys 
        515                 520                 525             


His Val Thr Ile His Arg Asp Gly Phe Trp Arg Glu Asn Thr Glu Leu 
    530                 535                 540                 


Ile Ser Glu Val Leu Gly Ala Lys Gly Ile Gln Phe Asp Ile Val Glu 
545                 550                 555                 560 


Val Ile Lys Ser Pro Lys Arg Arg Met Ala Tyr Tyr Asp Ser Lys Asp 
                565                 570                 575     


Asn Lys Met Glu Thr Arg Gln Gly Thr Tyr Tyr Phe Arg Gly Lys Glu 
            580                 585                 590         


Ala Leu Leu Cys Ala Thr Asn Pro Arg Glu Gln Ile Gly Met Ala Leu 
        595                 600                 605             


Pro Ile Lys Val Val Gln Lys Thr Ser Thr Leu Ser Phe Glu Gln Val 
    610                 615                 620                 


Ile Ser Asp Val Tyr Ala Leu Ser Phe Met His Val His Ala Leu Asn 
625                 630                 635                 640 


Lys Thr Arg Leu Pro Ala Thr Thr His Tyr Ala Asp Leu Ser Ser Thr 
                645                 650                 655     


Phe Tyr Gln Arg Gly Met Val Ala Ala Arg Thr Thr Asn Glu Thr His 
            660                 665                 670         


Leu Pro Phe Val 
        675     


<210>  17
<211>  724
<212>  PRT
<213>  Prochlorothrix hollandica PCC 9006 = CALU 1027


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A0M2PXX3

<400>  17

Met Ser Cys Asp Arg Leu Arg Pro Leu Thr Pro Ser Asp Gly Asp Pro 
1               5                   10                  15      


Ile Gln Asp Leu Arg Arg Leu Ala Ser Gln Ala Arg Tyr His Leu Lys 
            20                  25                  30          


His Trp Leu Glu Ile Asp Thr Ser Arg Ala Ala Leu Val Tyr Pro Pro 
        35                  40                  45              


His Leu Ala Trp Asp Arg Ile Ala Gly Ser Met Ala Arg Gly Tyr Arg 
    50                  55                  60                  


Ser Gln Ala Ser Gln Ala Val Val Glu Arg Leu Asp Thr Glu Pro Ile 
65                  70                  75                  80  


Asp Leu Ala Asp Pro Ile Arg Ser Ser Leu Leu Phe Lys Phe Cys Asn 
                85                  90                  95      


Tyr Gln Phe Asn Gly Ile Phe Lys Ala Met Arg Ser Ser His Val Leu 
            100                 105                 110         


Glu Ala Arg Lys Arg Ile Tyr Ser Leu Asp Pro Pro Lys Ile Ile Asp 
        115                 120                 125             


Asn Ser Ala Glu Ala Leu Leu Tyr Met Thr Phe Asp Phe Asn Arg Asp 
    130                 135                 140                 


Arg Glu Gly His Leu Ile Leu Val Met Asp Phe Ala His Glu Tyr Arg 
145                 150                 155                 160 


Ser Arg Gln Ser Leu Asp Arg Trp Gly Leu Gly Asn Leu Lys Pro Arg 
                165                 170                 175     


His Arg Leu Ser Gln Thr Tyr Asp His Lys Gly Cys Glu Trp Val Gly 
            180                 185                 190         


Met Ala Asp Ile Thr Ile Gly Glu Arg Val Ala Glu Leu Gly Asn Arg 
        195                 200                 205             


Ser Leu Leu Asp Tyr His Gln Glu Lys Gly Tyr Leu Lys Asn Ile Asn 
    210                 215                 220                 


Pro Asp Arg Leu Asp Pro Gln Gln Arg Ala Val Lys Ile Arg Tyr Phe 
225                 230                 235                 240 


Asn Gln Thr Lys Glu Ile Leu His Leu Pro Gln Leu Leu Gln Pro Leu 
                245                 250                 255     


Tyr Asp Arg Ser Asp Leu Asn Lys Lys Thr Leu Asp Thr Leu Ile Cys 
            260                 265                 270         


Ser Leu Thr Gln Lys Ile Glu Lys Ala Gln Lys Ala Ile Ala Ala Val 
        275                 280                 285             


Asn Ala Lys Gly Phe Tyr Cys Gly Asp Arg Leu Tyr Phe Glu Pro Ser 
    290                 295                 300                 


Leu Arg His Pro Pro Arg Leu Thr Thr Phe Val Gln Gly Asp Arg Gln 
305                 310                 315                 320 


Arg Asn Leu Asp Phe Gly Val Asp Cys Ala Thr Asn Pro Gln His Arg 
                325                 330                 335     


Tyr Tyr Ala Glu Pro Trp Gln Gly Trp Asn Asp Gln His Leu Leu Gln 
            340                 345                 350         


Lys Pro Asp Arg Ile Arg Thr Gln Val Leu Tyr Pro Glu Ala Trp Glu 
        355                 360                 365             


Pro Arg Met Lys Arg Tyr Met Gln Lys Leu Arg Glu Thr Phe Leu Lys 
    370                 375                 380                 


Phe Gly Ile Asp Leu Ser Pro Ala Gly Glu Ser Arg Ala Tyr Asn Pro 
385                 390                 395                 400 


Gln Asp Ala Met Gly Leu Gln Arg Val Cys Gln Gly Leu Pro Asp Ala 
                405                 410                 415     


Cys Gln Leu Val Phe Ala Phe Val Pro Asp Ser Arg Asp Arg Ser Tyr 
            420                 425                 430         


Asn Pro His Ile Asp Pro Tyr Lys Thr Phe Lys Arg Gln Leu His Arg 
        435                 440                 445             


Ala Lys Leu Pro Ser Gln Met Val Thr Gln Asp Thr Met Asn Gln Pro 
    450                 455                 460                 


Gly Asn Ser Gly Arg Asp Gln Asn Val Val Phe Gly Ile Leu Val Lys 
465                 470                 475                 480 


Leu Gly Tyr Leu Pro Trp Gln Leu Arg Ser Met Pro Gly Thr Ala Gln 
                485                 490                 495     


Ala Phe Val Gly Leu Asp Leu Gly Thr Lys Glu Gly Arg Thr Val Gly 
            500                 505                 510         


Ala Ser Ala Phe Val Val Asp Ala His Gly Gln Val Ile Gly Trp Ser 
        515                 520                 525             


Ser Val Ser Leu Gln Thr Gly Glu Thr Phe Ser Asp Asp Ser Leu Arg 
    530                 535                 540                 


Gln Ile Leu Arg Gly Leu Phe Gln Glu Phe Glu Leu Arg Thr Gly Asn 
545                 550                 555                 560 


Pro Leu Glu His Leu Val Ile His Arg Asp Gly Thr Phe Lys Thr Arg 
                565                 570                 575     


Glu Leu Ala Thr Leu Lys Ala Leu Glu Ala Glu Leu Arg Thr Gln Gly 
            580                 585                 590         


Leu Gln Arg Leu Asp Leu Val Glu Val Val Lys Gln His Leu Val Arg 
        595                 600                 605             


Ala Ala Gln Arg Val Glu Lys Asn Gly Thr Thr Thr Trp Asp Asn Pro 
    610                 615                 620                 


His Arg Gly Trp Gly Trp Glu His Ser Pro Gln Glu Ala Ile Val Leu 
625                 630                 635                 640 


Thr Thr Gly Lys Asn Glu Thr Lys Ile Ser Arg His Ala Ser Pro Lys 
                645                 650                 655     


Pro Leu Leu Ile Arg Arg Arg Gln Gly Asp Thr Asp Leu Leu Val Leu 
            660                 665                 670         


Ala Glu Gln Val Tyr Trp Leu Ser Lys Ile His Gly Gly Ser Ser Gln 
        675                 680                 685             


Thr Ile Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp Arg Ile Ala Glu 
    690                 695                 700                 


Val Thr Leu Gln Gly Leu Leu Pro Pro Asp Val Gln Arg Glu His Cys 
705                 710                 715                 720 


Leu Tyr Phe Val 
                


<210>  18
<211>  732
<212>  PRT
<213>  Pseudoalteromonas piscicida


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A0F4NXW8

<400>  18

Met Gln Asn Gln Ile Gly Ile Ser Ala Leu Gln Leu Ala Lys Ser Phe 
1               5                   10                  15      


Ser Ala Thr Arg Val Tyr Cys Tyr Gln Val Ala Phe Lys Lys Gln Ile 
            20                  25                  30          


Asp Ser Leu Glu Val Thr Lys Ala Met Arg Gln Leu Ala Asn Lys Leu 
        35                  40                  45              


Lys Trp Gln Asn Asn Ala Gln Ala Val Thr Asp Phe Ala Gly Phe Lys 
    50                  55                  60                  


Leu Ile Ser Leu Ala Pro Leu Thr Lys Leu Ala His Pro Asp Ala Gln 
65                  70                  75                  80  


Ile Thr Ala Leu Glu Pro Ile Thr Leu Leu Ala Gln Asn Gly Asn Glu 
                85                  90                  95      


Arg Glu Ala Leu Gln Arg Leu Ile Asn Gln Gly Ile Tyr Ser Gly Ala 
            100                 105                 110         


Tyr Arg Tyr Ala Lys Thr Arg Arg Leu Met Cys Lys Lys Ala Ala Thr 
        115                 120                 125             


Ala Thr Thr Gln Leu Ile Glu Gln Thr Pro Ser Asn Arg Val Ala Leu 
    130                 135                 140                 


Thr Ser Asn Phe Leu Glu Val Tyr Lys Thr Val Thr Leu Thr Pro Gln 
145                 150                 155                 160 


Leu Leu Ser Ser Gly Lys Cys Leu Val Gln Phe Glu Leu Lys His Ser 
                165                 170                 175     


Leu Ala Ala Lys His His Val Thr Leu Gln Trp Val Ile Thr Gln Arg 
            180                 185                 190         


Asn Ala Trp Leu Gly Ser Leu Arg Arg Val Arg Asn Arg Tyr Lys Ser 
        195                 200                 205             


Asn Asp Asp Met Thr Met Ser Phe Asp Phe Val Ala Val Glu Pro Asn 
    210                 215                 220                 


Leu Asn Ala Gln Ser Thr Pro Asp Gly Met Ala Met Ser Leu Leu Glu 
225                 230                 235                 240 


Tyr His Val Ser Gln Gly Asn Ile Asn Lys Asn Glu Leu Ala Ala Ala 
                245                 250                 255     


Glu Gln Ser Ala Val Val Lys Val Arg Thr Ala Lys Gly Gln Thr Leu 
            260                 265                 270         


Leu His Leu Ala Tyr Leu Leu Glu Pro Val Phe Asp Phe Asp Ser Leu 
        275                 280                 285             


Ser Val Leu Glu Pro Ala Leu Leu Asn Arg Ile Ala Lys Lys Leu Lys 
    290                 295                 300                 


Trp Gln Val Asn Glu Arg Ile His Glu Ala His Val Leu Cys Asn Gly 
305                 310                 315                 320 


Ile Glu Phe Tyr Glu Leu Ala Cys Gly Leu Thr Lys Ile Ser Glu Pro 
                325                 330                 335     


Gln Leu Ser Phe Asp Thr Leu Val Met Pro Trp Arg Leu Arg Phe Ala 
            340                 345                 350         


Thr Gly Ser Ser Ile His Glu Lys Asp Val Thr Ser Tyr Lys Ala Val 
        355                 360                 365             


Lys Pro Ile Thr Arg Glu Arg Ile Ile Pro Val Ile Val Gly Glu His 
    370                 375                 380                 


Asn Asn Thr Pro Lys Asn Arg Gln Arg Met Thr Asp Ser Ile Asn Ala 
385                 390                 395                 400 


Ile Ser Ala Leu Cys Asn Ser Ser Asn Asn Lys Ala Thr Pro Phe Val 
                405                 410                 415     


Val Ile Asn Ser Glu Leu Glu Leu Ala Asn Arg Leu Ala Ser Lys Glu 
            420                 425                 430         


Val Ser Asp Ala Ile Phe Leu Ile Gly Leu Cys Asp Lys Ala Asn Lys 
        435                 440                 445             


Ala Lys Leu Arg Asp Glu Ala Phe Ile Lys Gly Ala Ala Thr Gln Phe 
    450                 455                 460                 


Met Lys Leu Asp His Lys Pro Asn Ile Tyr Ser Thr Ser Tyr Tyr Arg 
465                 470                 475                 480 


Asn Val Ala Ala Gly Leu Phe Ser Lys Ala Gly Gly Gln Leu Val Ala 
                485                 490                 495     


Leu Ala Asn Met Pro Gly Gln Ala Asp Leu Phe Ile Gly Leu Asp Met 
            500                 505                 510         


Gly Gly Thr His Leu Arg Phe Pro Gly Val Ser Phe Leu Phe Ser Ala 
        515                 520                 525             


Thr Gly Ala Gln Leu Gly Trp Gln Ile Ala Asp Ser Gln Gln Gly Glu 
    530                 535                 540                 


Lys Leu Lys Glu Asn Ala Leu Thr Asp Leu Leu Tyr Lys Cys Leu Arg 
545                 550                 555                 560 


Asn Tyr Ala Gln Thr His Asn Gly Asn Lys Pro Lys His Ile Val Leu 
                565                 570                 575     


His Arg Asp Gly Lys Phe Tyr Glu Asp Leu Gly Gln Ile Lys Ala Phe 
            580                 585                 590         


Glu Gln Ala His Asp Leu Lys Ile Thr Val Val Glu Val Leu Lys Ser 
        595                 600                 605             


Gly Ala Pro Val Leu Phe Arg Arg Gly Lys Asn Gln Gln Gly Gln Lys 
    610                 615                 620                 


Val Phe Met Asn Pro Cys Val Gly Asp Tyr Ala Leu Leu Glu Glu Asn 
625                 630                 635                 640 


Glu Ala Ile Leu Ala Thr Tyr Ser Gly Gln Glu Leu Gly Lys Met Gly 
                645                 650                 655     


Glu Gln Val Thr Val Arg Pro Leu Arg Ile Arg Lys Val Tyr Gly Asp 
            660                 665                 670         


Ala Ala Leu Val Asp Val Leu Glu Gln Ile Thr Ala Leu Ser Arg Val 
        675                 680                 685             


His Gly Ala Ser Leu Tyr Arg His Pro Arg Leu Pro Val Thr Thr His 
    690                 695                 700                 


His Ala Asp Arg Phe Ala Thr Leu Arg Gln Asp Val Cys Val Asp Ala 
705                 710                 715                 720 


Leu Ser Arg Met Asp Arg Leu Cys Pro Val Tyr Leu 
                725                 730         


<210>  19
<211>  713
<212>  PRT
<213>  Stanieria cyanosphaera (strain ATCC 29371 / PCC 7437)


<220>
<221>  misc_feature
<223>  UniProt ID No: K9XZC6

<400>  19

Met Asn Asn Ser Ala Val Glu Val Phe Leu Asn Arg Phe Pro Val Lys 
1               5                   10                  15      


Arg Leu Thr Glu Ala Glu Arg Thr Val Gln Thr Tyr Thr Tyr Thr Phe 
            20                  25                  30          


Asn Pro Ser Pro Glu Pro Gly Lys Glu Tyr Ser Ala Ile Asn Arg Ile 
        35                  40                  45              


Thr Trp Asn Ile Gly Thr Pro Gly Val Arg Phe Gly Ser Thr Ile Ile 
    50                  55                  60                  


Thr Lys Gln Pro Ile Ala Glu Arg Tyr Leu Gln Gly Glu Asn Trp Leu 
65                  70                  75                  80  


Leu Lys Pro Gln Gly Thr Gln Leu Leu Asp Leu Asn Asn Ser Asn Glu 
                85                  90                  95      


Lys Glu Ala Leu Glu Arg Leu Glu Arg Arg Trp Leu Gly Trp Lys Leu 
            100                 105                 110         


Arg Gln Thr Ser Glu Lys Tyr Arg Leu Glu Asn Ser Pro Glu Gly Gly 
        115                 120                 125             


Phe Ile Trp Trp Asn Leu Asp Lys Thr Ile Leu Gln Gly Leu Gly Trp 
    130                 135                 140                 


Glu Val His Thr Gly Val Cys Leu Asp Ile Ser Ile His His Ser Gly 
145                 150                 155                 160 


Val Val Leu Thr Glu Ile Asp Ile His His Arg Phe Tyr Thr Ser Trp 
                165                 170                 175     


Thr Leu Glu Gln Trp Leu Gln Thr Tyr Pro Asp Leu Ser Ile Asn Trp 
            180                 185                 190         


Val Arg Asn Thr Tyr Asn Asp Arg Ser Trp Lys Phe Glu Arg Ile Ser 
        195                 200                 205             


Asp Glu Asn Pro Glu Thr Val Met Ile Pro Ser Gly Ser Leu Ala Asp 
    210                 215                 220                 


Tyr His Arg Asn Leu Glu Asn Asn Gln Ala Lys Glu Thr Glu Ile Ser 
225                 230                 235                 240 


Asn Ala Lys Val Val Tyr Val Ser Ser Lys Gly Asn Gln Glu Ile Pro 
                245                 250                 255     


His Leu Ser Thr Arg Leu Gln Pro Ser Ile Thr Met Glu Met Leu Ser 
            260                 265                 270         


Cys Leu Gln Asp Arg Gly Ser Gln Glu Ala Ala Lys Val Phe Lys Gln 
        275                 280                 285             


Ile Arg Gln Ser Ser Gln Val Arg Phe Asp Arg Gly Arg Asp Ile Ala 
    290                 295                 300                 


Lys Trp Leu Ala Ser Lys Ile Tyr His Val Glu Lys Gln Ile Asn Pro 
305                 310                 315                 320 


Gln Lys Ala Glu Gly Ile Met Leu Arg Asn Lys Phe Pro Leu Leu Ile 
                325                 330                 335     


Thr Lys Ser Lys Lys Val Tyr Arg Pro Glu Ala Ser Phe Lys Gln Gly 
            340                 345                 350         


Cys Phe Arg Thr Gly Glu Lys Gln Phe Gly Cys Leu Asp Leu Thr Gly 
        355                 360                 365             


Asn Gly Asp Trp Ser Glu Leu Ile Arg Asn Lys Leu Glu Asp Leu Ala 
    370                 375                 380                 


Gln Lys Ser Gly Val Asp Ile Leu Leu Glu Pro Ala Lys Lys Thr Thr 
385                 390                 395                 400 


Asp Leu Pro Asp Ser Leu Leu Thr Arg Lys Gln Phe Trp Gln Asp Trp 
                405                 410                 415     


Ala Asn Gln Gly Thr His Thr Val Leu Val Ile Thr Pro Trp Leu Gln 
            420                 425                 430         


Asn Thr Glu Lys Ser Arg Leu Gln Arg Glu Ala Leu Glu Ala Asn Ile 
        435                 440                 445             


Ala Leu Gln Phe Met Gln Pro Met Ser Lys Pro Asp Asn Tyr Arg Ala 
    450                 455                 460                 


Val Asn Ile Ile Leu Gly Leu Leu Leu Lys Ala Lys Trp Gln Pro Val 
465                 470                 475                 480 


Gly Leu Glu Pro Leu Gln Asp Glu Tyr Ala Ala Glu Leu Val Ile Gly 
                485                 490                 495     


Phe Asp Ala Gly Thr Asn Arg Asn Leu Tyr Tyr Gly Thr Ser Ala Phe 
            500                 505                 510         


Ala Ile Leu Ala Asn Gly Gln Ser Leu Gly Trp Glu Leu Pro Glu Ala 
        515                 520                 525             


Gln Pro Gly Glu Lys Leu Ser Gly Gln Ala Val Leu Asn Thr Val Ala 
    530                 535                 540                 


Asn Ile Ile Asn Arg Phe Gln Arg Ile Glu Asn Arg Leu Pro Lys Arg 
545                 550                 555                 560 


Ile Leu Leu Leu Arg Asp Gly Ile Val Gln Arg Asp Glu Phe Glu Ser 
                565                 570                 575     


Ala Ile Ala Leu Leu Gln Gln Asp His Ile Ala Val Asp Leu Leu Gly 
            580                 585                 590         


Val Arg Lys Ser Gly Ala Gly Arg Met Ala Val Ile Lys Gln Thr Ser 
        595                 600                 605             


Gly Asn Leu Ile Asp Val Leu Pro Gly Thr Ala Val Leu Ser His Asp 
    610                 615                 620                 


Gly Glu Thr Phe Arg Ile Val Thr Ser Glu Ala Lys Ala Gly Gly Ser 
625                 630                 635                 640 


Ala Arg Pro Leu Gln Val Leu Arg Asp Tyr Gly Asp Ala Pro Leu Glu 
                645                 650                 655     


Ile Leu Ala Arg Gln Ile Asp Arg Leu Cys Leu Leu Asn Pro Ala Ser 
            660                 665                 670         


Gly Tyr Ser Val Ser Arg Leu Pro Tyr Val Ile His Phe Ala Asp Lys 
        675                 680                 685             


Met Ala Lys Ile Val Gln Arg Ile Gly Glu Val Gly Val Leu Gln Gly 
    690                 695                 700                 


Ile Asp Arg Gln Lys Ile Phe Phe Ala 
705                 710             


<210>  20
<211>  718
<212>  PRT
<213>  Stanieria sp. NIES-3757


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A140KBY4

<400>  20

Met Asn Asn Ser Thr Leu Glu Val Phe Leu Asn Arg Phe Pro Val Lys 
1               5                   10                  15      


Arg Leu Thr Glu Val Glu Arg Thr Val His Thr Tyr Thr Tyr Thr Phe 
            20                  25                  30          


Asn Pro Ser Pro Glu Pro Gly Lys Glu Tyr Ser Ala Ile Asn Arg Ile 
        35                  40                  45              


Thr Trp Asn Ile Gly Thr Pro Gly Val Arg Phe Gly Ser Thr Ile Ile 
    50                  55                  60                  


Thr Lys Gln Thr Ile Ala Glu Gly Tyr Leu Gln Gly Glu Asn Trp Gln 
65                  70                  75                  80  


Leu Arg Ser Gln Gly Thr Gln Leu Leu Glu Leu Asn Lys Ser Asn Glu 
                85                  90                  95      


Arg Glu Ala Leu Glu Asn Leu Glu Arg Arg Trp Leu Gly Trp Lys Leu 
            100                 105                 110         


Arg Gln Thr Ser Glu Lys Ser Arg Ile Glu Asn Ser Pro Glu Gly Gly 
        115                 120                 125             


Phe Ile Trp Trp Asn Ala Gln Lys Thr Ile Val Gln Gly Leu Gly Trp 
    130                 135                 140                 


Glu Val His Thr Gly Val Arg Leu Asn Leu Ala Leu His His Ser Gly 
145                 150                 155                 160 


Ala Val Leu Thr Glu Ile Asp Ile His His Arg Phe Tyr Thr Ser Trp 
                165                 170                 175     


Thr Leu Glu Gln Trp Leu Gln Thr Tyr Pro Asp Ile Pro Ile Asn Trp 
            180                 185                 190         


Val Arg Asn Thr Tyr Asp Glu Arg Ser Trp Lys Phe Glu Arg Val Ser 
        195                 200                 205             


Asn Glu Asn Pro Glu Thr Thr Met Ile Pro Asn Leu Gly Ser Leu Ala 
    210                 215                 220                 


Asp Tyr His Arg Asn Leu Ser Lys Asn Pro Ala Thr Glu Ala Glu Ile 
225                 230                 235                 240 


Arg Asn Ala Arg Val Val Tyr Val Thr Ser Lys Gly Lys Glu Ile Pro 
                245                 250                 255     


His Leu Ser Thr Arg Leu Gln Pro Ser Ile Thr Met Glu Ile Leu Ser 
            260                 265                 270         


Cys Leu Gln Glu Arg Gly Ser Lys Glu Ala Ala Lys Val Phe Lys Gln 
        275                 280                 285             


Ile Arg Gln Ser Ser Gln Val Arg Phe Asp Arg Gly Arg Glu Ile Ala 
    290                 295                 300                 


Lys Trp Leu Ala Ser Asn Ile Tyr Asn Ile Asp Gln Lys Ile Ile Asp 
305                 310                 315                 320 


Ala Lys Ile Asn Pro Gln Lys Ala Glu Gly Ile Met Val Arg His Lys 
                325                 330                 335     


Ser Pro Leu Leu Met Ile Lys Ser Lys Lys Val Tyr Arg Pro Glu Ala 
            340                 345                 350         


Ser Leu Glu Gln Gly Cys Phe Gln Thr Gly Glu Lys Gln Phe Gly Cys 
        355                 360                 365             


Leu Asp Leu Thr Gly Asn Gly Asp Trp Ser Glu Leu Ile Arg Asn Lys 
    370                 375                 380                 


Leu Glu Thr Val Ala Lys Lys Ser Asn Val Asp Ile Val Leu Glu Pro 
385                 390                 395                 400 


Val Lys His Lys Thr Asp Leu Pro Asp Ser Leu Leu Thr Arg Lys Gln 
                405                 410                 415     


Phe Trp His Asp Trp Ala Asp Arg Gly Thr His Thr Val Leu Val Val 
            420                 425                 430         


Thr Pro Trp Leu Gln Asn Thr Glu Lys Ala Arg Leu Gln Arg Glu Ala 
        435                 440                 445             


Leu Ala Ala Asn Ile Ala Leu Gln Phe Met Gln Pro Met Ser Arg Pro 
    450                 455                 460                 


Asp Asn Tyr Arg Ala Val Asn Ile Ile Leu Gly Leu Leu Leu Lys Ala 
465                 470                 475                 480 


Lys Trp Gln Pro Val Ala Leu Glu Pro Leu Pro Asn Glu Tyr Ala Ala 
                485                 490                 495     


Glu Leu Val Ile Gly Phe Asp Ala Gly Thr Asn Arg Ser Leu Tyr Tyr 
            500                 505                 510         


Gly Thr Ser Ala Phe Ala Ile Leu Ala Asn Gly Gln Ser Leu Gly Trp 
        515                 520                 525             


Glu Leu Pro Glu Ala Gln Pro Gly Glu Lys Leu Ser Gly Gln Ala Val 
    530                 535                 540                 


Leu Arg Thr Val Ala His Leu Ile His Arg Phe Gln Arg Ile Glu Asn 
545                 550                 555                 560 


Arg Leu Pro Lys Arg Ile Leu Leu Leu Arg Asp Gly Ile Val Gln Arg 
                565                 570                 575     


Asp Glu Phe Ala Ser Ala Ile Ala Val Leu Gln Gln Asp His Ile Ala 
            580                 585                 590         


Val Asp Leu Leu Gly Val Arg Lys Ser Gly Ala Gly Arg Met Ala Val 
        595                 600                 605             


Ile Pro Tyr Gln Ser Glu Lys Leu Ile Asp Ala Leu Pro Gly Thr Thr 
    610                 615                 620                 


Val Leu Ser Glu Asp Gly Asp Thr Phe Arg Ile Val Thr Ser Glu Ala 
625                 630                 635                 640 


Lys Thr Gly Gly Ser Ala Arg Pro Leu Gln Val Val Arg Asp Tyr Gly 
                645                 650                 655     


Asp Ala Pro Leu Glu Ile Leu Ala Arg Gln Val Asp Arg Leu Cys Leu 
            660                 665                 670         


Leu Asn Pro Ala Ser Gly Tyr Ser Phe Ser Arg Leu Pro Tyr Val Ile 
        675                 680                 685             


His Phe Ala Asp Lys Met Ala Lys Thr Val Gln Arg Ile Gly Glu Val 
    690                 695                 700                 


Gly Ile Leu Gln Gly Ile Asp Arg Gln Lys Ile Phe Phe Ala 
705                 710                 715             


<210>  21
<211>  770
<212>  PRT
<213>  Pyrococcus furiosus COM1


<220>
<221>  misc_feature
<223>  UniProt ID No: I6U616

<400>  21

Met Lys Ala Lys Val Val Ile Asn Leu Val Lys Ile Asn Lys Lys Ile 
1               5                   10                  15      


Ile Pro Asp Lys Ile Tyr Val Tyr Arg Leu Phe Asn Asp Pro Glu Glu 
            20                  25                  30          


Glu Leu Gln Lys Glu Gly Tyr Ser Ile Tyr Arg Leu Ala Tyr Glu Asn 
        35                  40                  45              


Val Gly Ile Val Ile Asp Pro Glu Asn Leu Ile Ile Ala Thr Thr Lys 
    50                  55                  60                  


Glu Leu Glu Tyr Glu Gly Glu Phe Ile Pro Glu Gly Glu Ile Ser Phe 
65                  70                  75                  80  


Ser Glu Leu Arg Asn Asp Tyr Gln Ser Lys Leu Val Leu Arg Leu Leu 
                85                  90                  95      


Lys Glu Asn Gly Ile Gly Glu Tyr Glu Leu Ser Lys Leu Leu Arg Lys 
            100                 105                 110         


Phe Arg Lys Pro Lys Thr Phe Gly Asp Tyr Lys Val Ile Pro Ser Val 
        115                 120                 125             


Glu Met Ser Val Ile Lys His Asp Glu Asp Phe Tyr Leu Val Ile His 
    130                 135                 140                 


Ile Ile His Gln Ile Gln Ser Met Lys Thr Leu Trp Glu Leu Val Asn 
145                 150                 155                 160 


Lys Asp Pro Lys Glu Leu Glu Glu Phe Leu Met Thr His Lys Glu Asn 
                165                 170                 175     


Leu Met Leu Lys Asp Ile Ala Ser Pro Leu Lys Thr Val Tyr Lys Pro 
            180                 185                 190         


Cys Phe Glu Glu Tyr Thr Lys Lys Pro Lys Leu Asp His Asn Gln Glu 
        195                 200                 205             


Ile Val Lys Tyr Trp Tyr Asn Tyr His Ile Glu Arg Tyr Trp Asn Thr 
    210                 215                 220                 


Pro Glu Ala Lys Leu Glu Phe Tyr Arg Lys Phe Gly Gln Val Asp Leu 
225                 230                 235                 240 


Lys Gln Pro Ala Ile Leu Ala Lys Phe Ala Ser Lys Ile Lys Lys Asn 
                245                 250                 255     


Lys Asn Tyr Lys Ile Tyr Leu Leu Pro Gln Leu Val Val Pro Thr Tyr 
            260                 265                 270         


Asn Ala Glu Gln Leu Glu Ser Asp Val Ala Lys Glu Ile Leu Glu Tyr 
        275                 280                 285             


Thr Lys Leu Met Pro Glu Glu Arg Lys Glu Leu Leu Glu Asn Ile Leu 
    290                 295                 300                 


Ala Glu Val Asp Ser Asp Ile Ile Asp Lys Ser Leu Ser Glu Ile Glu 
305                 310                 315                 320 


Val Glu Lys Ile Ala Gln Glu Leu Glu Asn Lys Ile Arg Val Arg Asp 
                325                 330                 335     


Asp Lys Gly Asn Ser Val Pro Ile Ser Gln Leu Asn Val Gln Lys Ser 
            340                 345                 350         


Gln Leu Leu Leu Trp Thr Asn Tyr Ser Arg Lys Tyr Pro Val Ile Leu 
        355                 360                 365             


Pro Tyr Glu Val Pro Glu Lys Phe Arg Lys Ile Arg Glu Ile Pro Met 
    370                 375                 380                 


Phe Ile Ile Leu Asp Ser Gly Leu Leu Ala Asp Ile Gln Asn Phe Ala 
385                 390                 395                 400 


Thr Asn Glu Phe Arg Glu Leu Val Lys Ser Met Tyr Tyr Ser Leu Ala 
                405                 410                 415     


Lys Lys Tyr Asn Ser Leu Ala Lys Lys Ala Arg Ser Thr Asn Glu Ile 
            420                 425                 430         


Gly Leu Pro Phe Leu Asp Phe Arg Gly Lys Glu Lys Val Ile Thr Glu 
        435                 440                 445             


Asp Leu Asn Ser Asp Lys Gly Ile Ile Glu Val Val Glu Gln Val Ser 
    450                 455                 460                 


Ser Phe Met Lys Gly Lys Glu Leu Gly Leu Ala Phe Ile Ala Ala Arg 
465                 470                 475                 480 


Asn Lys Leu Ser Ser Glu Lys Phe Glu Glu Ile Lys Arg Arg Leu Phe 
                485                 490                 495     


Asn Leu Asn Val Ile Ser Gln Val Val Asn Glu Asp Thr Leu Lys Asn 
            500                 505                 510         


Lys Arg Asp Lys Tyr Asp Arg Asn Arg Leu Asp Leu Phe Val Arg His 
        515                 520                 525             


Asn Leu Leu Phe Gln Val Leu Ser Lys Leu Gly Val Lys Tyr Tyr Val 
    530                 535                 540                 


Leu Asp Tyr Arg Phe Asn Tyr Asp Tyr Ile Ile Gly Ile Asp Val Ala 
545                 550                 555                 560 


Pro Met Lys Arg Ser Glu Gly Tyr Ile Gly Gly Ser Ala Val Met Phe 
                565                 570                 575     


Asp Ser Gln Gly Tyr Ile Arg Lys Ile Val Pro Ile Lys Ile Gly Glu 
            580                 585                 590         


Gln Arg Gly Glu Ser Val Asp Met Asn Glu Phe Phe Lys Glu Met Val 
        595                 600                 605             


Asp Lys Phe Lys Glu Phe Asn Ile Lys Leu Asp Asn Lys Lys Ile Leu 
    610                 615                 620                 


Leu Leu Arg Asp Gly Arg Ile Thr Asn Asn Glu Glu Glu Gly Leu Lys 
625                 630                 635                 640 


Tyr Ile Ser Glu Met Phe Asp Ile Glu Val Val Thr Met Asp Val Ile 
                645                 650                 655     


Lys Asn His Pro Val Arg Ala Phe Ala Asn Met Lys Met Tyr Phe Asn 
            660                 665                 670         


Leu Gly Gly Ala Ile Tyr Leu Ile Pro His Lys Leu Lys Gln Ala Lys 
        675                 680                 685             


Gly Thr Pro Ile Pro Ile Lys Leu Ala Lys Lys Arg Ile Ile Lys Asn 
    690                 695                 700                 


Gly Lys Val Glu Lys Gln Ser Ile Thr Arg Gln Asp Val Leu Asp Ile 
705                 710                 715                 720 


Phe Ile Leu Thr Arg Leu Asn Tyr Gly Ser Ile Ser Ala Asp Met Arg 
                725                 730                 735     


Leu Pro Ala Pro Val His Tyr Ala His Lys Phe Ala Asn Ala Ile Arg 
            740                 745                 750         


Asn Glu Trp Lys Ile Lys Glu Glu Phe Leu Ala Glu Gly Phe Leu Tyr 
        755                 760                 765             


Phe Val 
    770 


<210>  22
<211>  685
<212>  PRT
<213>  Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)


<220>
<221>  misc_feature
<223>  UniProt ID No: Q746M7

<400>  22

Met Asn His Leu Gly Lys Thr Glu Val Phe Leu Asn Arg Phe Ala Leu 
1               5                   10                  15      


Arg Pro Leu Asn Pro Glu Glu Leu Arg Pro Trp Arg Leu Glu Val Val 
            20                  25                  30          


Leu Asp Pro Pro Pro Gly Arg Glu Glu Val Tyr Pro Leu Leu Ala Gln 
        35                  40                  45              


Val Ala Arg Arg Ala Gly Gly Val Thr Val Arg Met Gly Asp Gly Leu 
    50                  55                  60                  


Ala Ser Trp Ser Pro Pro Glu Val Leu Val Leu Glu Gly Thr Leu Ala 
65                  70                  75                  80  


Arg Met Gly Gln Thr Tyr Ala Tyr Arg Leu Tyr Pro Lys Gly Arg Arg 
                85                  90                  95      


Pro Leu Asp Pro Lys Asp Pro Gly Glu Arg Ser Val Leu Ser Ala Leu 
            100                 105                 110         


Ala Arg Arg Leu Leu Gln Glu Arg Leu Arg Arg Leu Glu Gly Val Trp 
        115                 120                 125             


Val Glu Gly Leu Ala Val Tyr Arg Arg Glu His Ala Arg Gly Pro Gly 
    130                 135                 140                 


Trp Arg Val Leu Gly Gly Ala Val Leu Asp Leu Trp Val Ser Asp Ser 
145                 150                 155                 160 


Gly Ala Phe Leu Leu Glu Val Asp Pro Ala Tyr Arg Ile Leu Cys Glu 
                165                 170                 175     


Met Ser Leu Glu Ala Trp Leu Ala Gln Gly His Pro Leu Pro Lys Arg 
            180                 185                 190         


Val Arg Asn Ala Tyr Asp Arg Arg Thr Trp Glu Leu Leu Arg Leu Gly 
        195                 200                 205             


Glu Glu Asp Pro Lys Glu Leu Pro Leu Pro Gly Gly Leu Ser Leu Leu 
    210                 215                 220                 


Asp Tyr His Ala Ser Lys Gly Arg Leu Gln Gly Arg Glu Gly Gly Arg 
225                 230                 235                 240 


Val Ala Trp Val Ala Asp Pro Lys Asp Pro Arg Lys Pro Ile Pro His 
                245                 250                 255     


Leu Thr Gly Leu Leu Val Pro Val Leu Thr Leu Glu Asp Leu His Glu 
            260                 265                 270         


Glu Glu Gly Ser Leu Ala Leu Ser Leu Pro Trp Glu Glu Arg Arg Arg 
        275                 280                 285             


Arg Thr Arg Glu Ile Ala Ser Trp Ile Gly Arg Arg Leu Gly Leu Gly 
    290                 295                 300                 


Thr Pro Glu Ala Val Arg Ala Gln Ala Tyr Arg Leu Ser Ile Pro Lys 
305                 310                 315                 320 


Leu Met Gly Arg Arg Ala Val Ser Lys Pro Ala Asp Ala Leu Arg Val 
                325                 330                 335     


Gly Phe Tyr Arg Ala Gln Glu Thr Ala Leu Ala Leu Leu Arg Leu Asp 
            340                 345                 350         


Gly Ala Gln Gly Trp Pro Glu Phe Leu Arg Arg Ala Leu Leu Arg Ala 
        355                 360                 365             


Phe Gly Ala Ser Gly Ala Ser Leu Arg Leu His Thr Leu His Ala His 
    370                 375                 380                 


Pro Ser Gln Gly Leu Ala Phe Arg Glu Ala Leu Arg Lys Ala Lys Glu 
385                 390                 395                 400 


Glu Gly Val Gln Ala Val Leu Val Leu Thr Pro Pro Met Ala Trp Glu 
                405                 410                 415     


Asp Arg Asn Arg Leu Lys Ala Leu Leu Leu Arg Glu Gly Leu Pro Ser 
            420                 425                 430         


Gln Ile Leu Asn Val Pro Leu Arg Glu Glu Glu Arg His Arg Trp Glu 
        435                 440                 445             


Asn Ala Leu Leu Gly Leu Leu Ala Lys Ala Gly Leu Gln Val Val Ala 
    450                 455                 460                 


Leu Ser Gly Ala Tyr Pro Ala Glu Leu Ala Val Gly Phe Asp Ala Gly 
465                 470                 475                 480 


Gly Arg Glu Ser Phe Arg Phe Gly Gly Ala Ala Cys Ala Val Gly Gly 
                485                 490                 495     


Asp Gly Gly His Leu Leu Trp Thr Leu Pro Glu Ala Gln Ala Gly Glu 
            500                 505                 510         


Arg Ile Pro Gln Glu Val Val Trp Asp Leu Leu Glu Glu Thr Leu Trp 
        515                 520                 525             


Ala Phe Arg Arg Lys Ala Gly Arg Leu Pro Ser Arg Val Leu Leu Leu 
    530                 535                 540                 


Arg Asp Gly Arg Val Pro Gln Asp Glu Phe Ala Leu Ala Leu Glu Ala 
545                 550                 555                 560 


Leu Ala Arg Glu Gly Ile Ala Tyr Asp Leu Val Ser Val Arg Lys Ser 
                565                 570                 575     


Gly Gly Gly Arg Val Tyr Pro Val Gln Gly Arg Leu Ala Asp Gly Leu 
            580                 585                 590         


Tyr Val Pro Leu Glu Asp Lys Thr Phe Leu Leu Leu Thr Val His Arg 
        595                 600                 605             


Asp Phe Arg Gly Thr Pro Arg Pro Leu Lys Leu Val His Glu Ala Gly 
    610                 615                 620                 


Asp Thr Pro Leu Glu Ala Leu Ala His Gln Ile Phe His Leu Thr Arg 
625                 630                 635                 640 


Leu Tyr Pro Ala Ser Gly Phe Ala Phe Pro Arg Leu Pro Ala Pro Leu 
                645                 650                 655     


His Leu Ala Asp Arg Leu Val Lys Glu Val Gly Arg Leu Gly Ile Arg 
            660                 665                 670         


His Leu Lys Glu Val Asp Arg Glu Lys Leu Phe Phe Val 
        675                 680                 685 


<210>  23
<211>  710
<212>  PRT
<213>  Geobacillus stearothermophilus


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A0K9HMC6

<400>  23

Met Asn His Tyr Tyr Phe Ser Glu Cys Lys Ala Asp Glu Lys Ala Ser 
1               5                   10                  15      


Asp Ile Ala Ile His Leu Tyr Thr Val Pro Leu Ser Asn Pro His Glu 
            20                  25                  30          


Lys Tyr Ser Tyr Ala His Ser Ile Ala Tyr Glu Leu Arg Lys Leu Asn 
        35                  40                  45              


Ser Tyr Ile Thr Val Val Ala His Gly Gln Tyr Ile Ala Ser Phe Glu 
    50                  55                  60                  


Glu Ile Cys His Trp Gly Asp His Arg Tyr Ile Gln His Glu His Arg 
65                  70                  75                  80  


Pro Ile Gln Cys Ser Leu Pro Met Glu Arg Thr Ile Leu Glu Arg Leu 
                85                  90                  95      


Leu Lys Lys Glu Leu Glu Asn Arg Cys Lys Ser Ser Tyr Lys Met Asp 
            100                 105                 110         


Asn Asp Leu Phe Arg Leu Ala Asn Glu Gln Ser Met His Val Gly Glu 
        115                 120                 125             


Ile Ser Ile His Pro Ala Ile Tyr Ile Ser Phe Ser Val Glu Glu Asn 
    130                 135                 140                 


Gly Asp Ile Phe Val Gly Phe Asp Tyr Gln His Arg Phe Glu Tyr Arg 
145                 150                 155                 160 


Lys Thr Leu Gln Asp Val Ile Asn Asn Asp Pro Ser Leu Leu Lys Glu 
                165                 170                 175     


Gly Met Glu Val Val Asp Pro Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr 
            180                 185                 190         


Phe Val Gly Met Ala Asp Tyr Thr Ala Gly Gln Lys Ser Pro Phe Leu 
        195                 200                 205             


Gln Gln Ser Val Ile Asp Tyr Tyr Leu Glu Lys Asn Glu Arg Trp Lys 
    210                 215                 220                 


Leu Lys Gly Val His Glu Lys Thr Pro Val Val His Val Lys Asn Arg 
225                 230                 235                 240 


Asp Gly His Leu Leu Pro Tyr Leu Pro His Leu Leu Lys Leu Thr Cys 
                245                 250                 255     


Ser Tyr Glu Gln Leu Pro Pro Ser Met Thr Lys Lys Val Asn Arg Leu 
            260                 265                 270         


Ile Lys Leu Ser Pro His Glu Lys Met Phe Lys Leu Tyr Thr Glu Thr 
        275                 280                 285             


Phe Arg Leu Leu Arg Gln Gln Gln Val Leu Thr Phe Gln Lys Glu Asn 
    290                 295                 300                 


Val Arg Ala Val Asn Leu Gly Tyr Asp Val Asn Glu Leu Asp Ser Pro 
305                 310                 315                 320 


Ile Met Glu Phe Gly Gln Gly Tyr Lys Thr Asn Glu Ile Tyr Arg Gly 
                325                 330                 335     


Leu Lys Gln Ser Gly Val Tyr Glu Pro Ser Asn Val Ala Val Ser Tyr 
            340                 345                 350         


Phe Val Asp Pro Glu Leu Asn Tyr Asp Pro Gln Lys Arg Lys Glu Val 
        355                 360                 365             


Gly Cys Phe Val Lys Lys Leu Glu Ser Met Ser Glu Ala Leu Gly Val 
    370                 375                 380                 


Lys Leu Asn Ile Ser Asp Gln Pro Arg Gln Leu Tyr Gly Gln Leu Pro 
385                 390                 395                 400 


Lys Asp Phe Phe Lys Gln Asp Asn Leu Ser Tyr His Leu Lys Ser Ile 
                405                 410                 415     


Thr Asp Gln Phe Arg Gly Thr Val Val Val Val Ile Gly Thr Glu Glu 
            420                 425                 430         


Asn Ile Asp Arg Ala Tyr Val Thr Ile Lys Lys Glu Phe Gly Gly Lys 
        435                 440                 445             


Glu Asp Leu Met Thr Gln Phe Val Gly Phe Thr Ser Ser Leu Val Thr 
    450                 455                 460                 


Glu Asn Asn Ile Phe His Tyr Tyr Asn Ile Leu Leu Gly Ile Tyr Ala 
465                 470                 475                 480 


Lys Ala Gly Ile Gln Pro Trp Ile Leu Ala Ser Pro Met His Ser Asp 
                485                 490                 495     


Cys Phe Ile Gly Leu Asp Val Ser His Glu His Gly Lys His Ala Ser 
            500                 505                 510         


Gly Ile Ile Gln Val Ile Gly Arg Asp Gly Lys Ile Ile Lys Gln Lys 
        515                 520                 525             


Ser Val Ala Thr Ala Glu Ala Gly Glu Thr Ile Ala Asn Ser Thr Met 
    530                 535                 540                 


Glu Glu Ile Val Asn Glu Ser Ile Tyr Ser Tyr Glu Gln Ile Tyr Gly 
545                 550                 555                 560 


Ala Lys Pro Arg His Ile Thr Phe His Arg Asp Gly Ile Trp Arg Glu 
                565                 570                 575     


Asp Leu Asp Phe Leu Gln Ala Tyr Leu Arg Ser Phe Gln Ile Pro Phe 
            580                 585                 590         


Asp Phe Val Glu Ile Ile Lys Lys Pro Arg Arg Arg Met Ala Ile Tyr 
        595                 600                 605             


Ser Asn Lys Lys Trp Val Thr Lys Gln Gly Ile Tyr Tyr Ser Lys Gly 
    610                 615                 620                 


Asn Thr Ala Tyr Leu Cys Ala Thr Asp Pro Arg Glu Ser Val Gly Met 
625                 630                 635                 640 


Ala Gln Leu Val Lys Ile Val Gln Lys Thr Asn Gly Leu Ser Val His 
                645                 650                 655     


Glu Ile Val Ser Asp Val Tyr Lys Leu Ser Phe Met His Ile His Ser 
            660                 665                 670         


Met Leu Lys Thr Arg Leu Pro Ile Thr Ile His Tyr Ser Asp Leu Ser 
        675                 680                 685             


Ser Thr Phe His Asn Arg Gly Leu Ile His Pro Arg Ser Gln His Glu 
    690                 695                 700                 


Arg Ala Leu Pro Phe Val 
705                 710 


<210>  24
<211>  710
<212>  PRT
<213>  Geobacillus thermoleovorans


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A098L665

<400>  24

Met Asn His Tyr Tyr Phe Ser Glu Cys Lys Ala Asp Glu Lys Ala Ser 
1               5                   10                  15      


Asp Ile Ala Ile His Leu Tyr Thr Val Pro Leu Ser Asn Pro His Glu 
            20                  25                  30          


Lys Tyr Ser Tyr Ala His Ser Ile Ala Tyr Glu Leu Arg Lys Leu Asn 
        35                  40                  45              


Ser Tyr Ile Thr Val Ala Ala His Gly Gln Tyr Ile Ala Ser Phe Glu 
    50                  55                  60                  


Glu Ile Cys His Trp Gly Asp His Arg Tyr Ile Gln His Glu His Arg 
65                  70                  75                  80  


Pro Ile Gln Cys Ser Leu Pro Met Glu Arg Thr Ile Leu Glu Arg Leu 
                85                  90                  95      


Leu Lys Lys Glu Leu Glu Asn Arg Cys Lys Ser Ser Tyr Lys Met Asp 
            100                 105                 110         


Asn Asp Leu Phe Arg Leu Ala Asn Glu Gln Ser Met His Val Gly Glu 
        115                 120                 125             


Ile Ser Ile His Pro Ala Ile Tyr Ile Ser Phe Ser Val Glu Glu Asn 
    130                 135                 140                 


Gly Asp Ile Phe Val Gly Phe Asp Tyr Gln His Arg Phe Glu Tyr Arg 
145                 150                 155                 160 


Lys Thr Leu Gln Asp Val Ile Asn Asn Asp Pro Ser Leu Leu Lys Glu 
                165                 170                 175     


Gly Met Glu Val Val Asp Pro Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr 
            180                 185                 190         


Phe Val Gly Met Ala Asp Tyr Thr Ala Gly Gln Lys Ser Pro Phe Leu 
        195                 200                 205             


Gln Gln Ser Val Ile Asp Tyr Tyr Leu Glu Lys Asn Glu Leu Trp Lys 
    210                 215                 220                 


Leu Lys Gly Val His Glu Lys Thr Pro Val Val His Val Lys Ser Arg 
225                 230                 235                 240 


Asp Gly His Leu Leu Pro Tyr Leu Pro His Leu Leu Lys Leu Thr Cys 
                245                 250                 255     


Ser Tyr Glu Gln Leu Leu Pro Ser Met Thr Lys Glu Val Asn Arg Leu 
            260                 265                 270         


Ile Lys Leu Ser Pro Asn Glu Lys Met Ser Lys Leu Tyr Thr Glu Met 
        275                 280                 285             


Phe Arg Leu Leu Arg Gln Gln Gln Val Leu Thr Phe Lys Lys Glu Asn 
    290                 295                 300                 


Val Arg Ala Val Asn Leu Gly Tyr Asp Val Asn Glu Leu Asp Ser Pro 
305                 310                 315                 320 


Ile Met Glu Phe Gly Gln Gly Tyr Lys Thr Asn Glu Ile Tyr Arg Gly 
                325                 330                 335     


Leu Lys Gln Ser Gly Val Tyr Glu Pro Ser Ser Val Ala Val Ser Phe 
            340                 345                 350         


Phe Val Asp Pro Glu Leu Asn Tyr Asp Pro Gln Lys Arg Lys Glu Val 
        355                 360                 365             


Gly Cys Phe Val Lys Lys Leu Glu Ser Met Ser Glu Ala Leu Gly Val 
    370                 375                 380                 


Lys Leu Asn Ile Ser Asp Gln Pro Arg Gln Leu Tyr Gly Gln Leu Pro 
385                 390                 395                 400 


Lys Asp Phe Phe Lys Gln Asp Asn Leu Ser Tyr His Leu Lys Ser Ile 
                405                 410                 415     


Thr Asp Gln Phe Arg Gly Thr Val Val Val Val Ile Gly Thr Glu Glu 
            420                 425                 430         


Asn Ile Asp Arg Ala Tyr Val Thr Ile Lys Lys Glu Phe Gly Gly Lys 
        435                 440                 445             


Glu Asp Leu Met Thr Gln Phe Val Gly Phe Thr Ser Ser Leu Val Thr 
    450                 455                 460                 


Glu Asn Asn Ile Phe His Tyr Tyr Asn Ile Leu Leu Gly Ile Tyr Ala 
465                 470                 475                 480 


Lys Ala Gly Val Gln Pro Trp Ile Leu Ala Ser Pro Met His Ser Asp 
                485                 490                 495     


Cys Phe Ile Gly Leu Asp Val Ser His Glu His Gly Lys His Ala Ser 
            500                 505                 510         


Gly Ile Ile Gln Val Ile Gly Arg Asp Gly Lys Ile Ile Lys Gln Lys 
        515                 520                 525             


Ser Val Ala Thr Ala Glu Ala Gly Glu Thr Ile Ala Asn Ser Thr Met 
    530                 535                 540                 


Glu Glu Ile Val Asn Glu Ser Ile Tyr Ser Tyr Glu Gln Ile Tyr Gly 
545                 550                 555                 560 


Ala Lys Pro Arg His Ile Thr Phe His Arg Asp Gly Ile Cys Arg Glu 
                565                 570                 575     


Asp Leu Asp Phe Leu Gln Ala Tyr Leu Arg Ser Phe Gln Ile Pro Phe 
            580                 585                 590         


Asp Phe Val Glu Ile Ile Lys Lys Pro Arg Arg Arg Met Ala Ile Tyr 
        595                 600                 605             


Ser Asn Lys Lys Trp Val Thr Lys Gln Gly Ile Tyr Tyr Ser Lys Gly 
    610                 615                 620                 


Asn Thr Ala Tyr Leu Cys Ala Thr Asp Pro Arg Glu Ser Val Gly Met 
625                 630                 635                 640 


Ala Gln Leu Val Lys Ile Val Gln Lys Thr Asn Gly Leu Ser Val His 
                645                 650                 655     


Glu Ile Val Ser Asp Val Tyr Lys Leu Ser Phe Met His Ile His Ser 
            660                 665                 670         


Met Leu Lys Thr Arg Leu Pro Ile Thr Ile His Tyr Ser Asp Leu Ser 
        675                 680                 685             


Ser Thr Phe His Asn Arg Gly Leu Ile His Pro Arg Ser Gln His Glu 
    690                 695                 700                 


Arg Ala Leu Pro Phe Val 
705                 710 


<210>  25
<211>  710
<212>  PRT
<213>  Geobacillus sp. 1017


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A1Q5SQX4

<400>  25

Met Asn His Tyr Tyr Phe Ser Glu Cys Lys Ala Asp Glu Lys Ala Ser 
1               5                   10                  15      


Asp Ile Ala Ile His Leu Tyr Thr Val Pro Leu Ser Asn Pro His Glu 
            20                  25                  30          


Lys Tyr Ser Tyr Ala His Ser Ile Ala Tyr Glu Leu Arg Lys Leu Asn 
        35                  40                  45              


Ser Tyr Ile Thr Val Ala Ala His Gly Gln Tyr Ile Ala Ser Phe Glu 
    50                  55                  60                  


Glu Ile Cys His Trp Gly Asp His Arg Tyr Ile Gln His Glu His Arg 
65                  70                  75                  80  


Pro Ile Gln Cys Ser Leu Pro Met Glu Arg Thr Ile Leu Glu Arg Leu 
                85                  90                  95      


Leu Lys Lys Glu Leu Glu Asn Arg Cys Lys Ser Ser Tyr Lys Met Asp 
            100                 105                 110         


Asn Asp Leu Phe Arg Leu Ala Asn Glu Gln Ser Met His Val Gly Glu 
        115                 120                 125             


Ile Ser Ile His Pro Ala Ile Tyr Ile Ser Phe Ser Val Glu Glu Asn 
    130                 135                 140                 


Gly Asp Ile Phe Val Gly Phe Asp Tyr Gln His Arg Phe Glu Tyr Arg 
145                 150                 155                 160 


Lys Thr Leu Gln Asp Val Ile Asn Asn Asp Pro Ser Leu Leu Lys Glu 
                165                 170                 175     


Gly Met Glu Val Val Asp Pro Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr 
            180                 185                 190         


Phe Val Gly Met Ala Asp Tyr Thr Ala Gly Gln Lys Ser Pro Phe Leu 
        195                 200                 205             


Gln Gln Ser Val Ile Asp Tyr Tyr Leu Glu Lys Asn Glu Leu Trp Lys 
    210                 215                 220                 


Leu Lys Gly Val His Glu Lys Thr Pro Val Val His Val Lys Ser Arg 
225                 230                 235                 240 


Asp Gly His Leu Leu Pro Tyr Leu Pro His Leu Leu Lys Leu Thr Cys 
                245                 250                 255     


Ser Tyr Glu Gln Leu Leu Pro Ser Met Thr Lys Glu Val Asn Arg Leu 
            260                 265                 270         


Ile Lys Leu Ser Pro Asn Glu Lys Met Ser Lys Leu Tyr Thr Glu Met 
        275                 280                 285             


Phe Arg Leu Leu Arg Gln Gln Gln Val Leu Thr Phe Lys Lys Glu Asn 
    290                 295                 300                 


Val Arg Ala Val Asn Leu Gly Tyr Asp Val Asn Glu Leu Asp Ser Pro 
305                 310                 315                 320 


Ile Met Glu Phe Gly Gln Gly Tyr Lys Thr Asn Glu Ile Tyr Arg Gly 
                325                 330                 335     


Leu Lys Gln Ser Gly Val Tyr Glu Pro Ser Ser Val Ala Val Ser Phe 
            340                 345                 350         


Phe Val Asp Pro Glu Leu Asn Tyr Asp Pro Gln Lys Arg Lys Glu Val 
        355                 360                 365             


Gly Cys Phe Val Lys Lys Leu Glu Ser Met Ser Glu Ala Leu Gly Val 
    370                 375                 380                 


Lys Leu Asn Ile Ser Asp Gln Pro Arg Gln Leu Tyr Gly Gln Leu Pro 
385                 390                 395                 400 


Lys Asp Phe Phe Lys Gln Asp Asn Leu Ser Tyr His Leu Lys Ser Ile 
                405                 410                 415     


Thr Asp Gln Phe Arg Gly Thr Val Val Val Val Ile Gly Thr Glu Glu 
            420                 425                 430         


Asn Ile Asp Arg Ala Tyr Val Thr Ile Lys Lys Glu Phe Gly Gly Lys 
        435                 440                 445             


Glu Asp Leu Met Thr Gln Phe Val Gly Phe Thr Ser Ser Leu Val Thr 
    450                 455                 460                 


Glu Asn Asn Ile Phe His Tyr Tyr Asn Ile Leu Leu Gly Ile Tyr Ala 
465                 470                 475                 480 


Lys Ala Gly Val Gln Pro Trp Ile Leu Ala Ser Pro Met His Ser Asp 
                485                 490                 495     


Cys Phe Ile Gly Leu Asp Val Ser His Glu His Gly Lys His Ala Ser 
            500                 505                 510         


Gly Ile Ile Gln Val Ile Gly Arg Asp Gly Lys Ile Ile Lys Gln Lys 
        515                 520                 525             


Ser Val Ala Thr Ala Glu Ala Gly Glu Thr Ile Ala Asn Ser Thr Met 
    530                 535                 540                 


Glu Glu Ile Val Asn Glu Ser Ile Tyr Ser Tyr Glu Gln Ile Tyr Gly 
545                 550                 555                 560 


Ala Lys Pro Arg His Ile Thr Phe His Arg Asp Gly Ile Cys Arg Glu 
                565                 570                 575     


Asp Leu Asp Phe Leu Gln Ala Tyr Leu Arg Ser Phe Gln Ile Pro Phe 
            580                 585                 590         


Asp Phe Val Glu Ile Ile Lys Lys Pro Arg Arg Arg Met Ala Ile Tyr 
        595                 600                 605             


Ser Asn Lys Lys Trp Val Thr Lys Gln Gly Ile Tyr Tyr Ser Lys Gly 
    610                 615                 620                 


Asn Thr Ala Tyr Leu Cys Ala Thr Asp Pro Arg Glu Ser Val Gly Met 
625                 630                 635                 640 


Ala Gln Leu Val Lys Ile Val Gln Lys Thr Asn Gly Leu Ser Val His 
                645                 650                 655     


Glu Ile Val Ser Asp Val Tyr Lys Leu Ser Phe Met His Ile His Ser 
            660                 665                 670         


Met Leu Lys Thr Arg Leu Pro Ile Thr Ile His Tyr Ser Asp Leu Ser 
        675                 680                 685             


Ser Thr Phe His Asn Arg Gly Leu Ile His Pro Arg Ser Gln His Glu 
    690                 695                 700                 


Arg Ala Leu Pro Phe Val 
705                 710 


<210>  26
<211>  710
<212>  PRT
<213>  Geobacillus kaustophilus GBlys


<220>
<221>  misc_feature
<223>  UniProt ID No: U2X7T6

<400>  26

Met Asn His Tyr Tyr Phe Ser Glu Cys Lys Ala Asp Glu Lys Ala Ser 
1               5                   10                  15      


Asp Ile Ala Ile His Leu Tyr Thr Val Pro Leu Ser Asn Pro His Glu 
            20                  25                  30          


Lys Tyr Ser Tyr Ala His Ser Ile Ala Tyr Glu Leu Arg Lys Leu Asn 
        35                  40                  45              


Ser Tyr Ile Thr Val Ala Ala His Gly Gln Tyr Ile Ala Ser Phe Glu 
    50                  55                  60                  


Glu Ile Cys His Trp Gly Asp His Arg Tyr Ile Gln His Glu His Arg 
65                  70                  75                  80  


Pro Ile Gln Cys Ser Leu Pro Met Glu Arg Thr Ile Leu Glu Arg Leu 
                85                  90                  95      


Leu Lys Lys Glu Leu Glu Asn Arg Cys Lys Ser Ser Tyr Lys Met Asp 
            100                 105                 110         


Asn Asp Leu Phe Arg Leu Ala Asn Glu Gln Ser Met His Val Gly Glu 
        115                 120                 125             


Ile Ser Ile His Pro Ala Ile Tyr Ile Ser Phe Ser Val Glu Glu Asn 
    130                 135                 140                 


Gly Asp Ile Phe Val Gly Phe Asp Tyr Gln His Arg Phe Glu Tyr Arg 
145                 150                 155                 160 


Lys Thr Leu Gln Asp Val Ile Asn Asn Asp Pro Ser Leu Leu Lys Glu 
                165                 170                 175     


Gly Met Glu Val Val Asp Pro Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr 
            180                 185                 190         


Phe Val Gly Met Ala Asp Tyr Thr Ala Gly Gln Lys Ser Pro Phe Leu 
        195                 200                 205             


Gln Gln Ser Val Ile Asp Tyr Tyr Leu Glu Lys Asn Glu Leu Trp Lys 
    210                 215                 220                 


Leu Lys Gly Val His Glu Lys Thr Pro Val Val His Val Lys Ser Arg 
225                 230                 235                 240 


Asp Gly His Leu Leu Pro Tyr Leu Pro His Leu Leu Lys Leu Thr Cys 
                245                 250                 255     


Ser Tyr Glu Gln Leu Leu Pro Ser Met Thr Lys Glu Val Asn Arg Leu 
            260                 265                 270         


Ile Lys Leu Ser Pro Asn Glu Lys Met Ser Lys Leu Tyr Thr Glu Met 
        275                 280                 285             


Phe Arg Leu Leu Arg Gln Gln Gln Val Leu Thr Phe Lys Lys Glu Asn 
    290                 295                 300                 


Val Arg Ala Val Asn Leu Gly Tyr Asp Val Asn Glu Leu Asp Ser Pro 
305                 310                 315                 320 


Ile Met Glu Phe Gly Gln Gly Tyr Lys Thr Asn Glu Ile Tyr Arg Gly 
                325                 330                 335     


Leu Lys Gln Ser Gly Val Tyr Glu Pro Ser Ser Val Ala Val Ser Phe 
            340                 345                 350         


Phe Val Asp Pro Glu Leu Asn Tyr Asp Pro Gln Lys Arg Lys Glu Val 
        355                 360                 365             


Gly Cys Phe Val Lys Lys Leu Glu Ser Met Ser Glu Ala Leu Gly Val 
    370                 375                 380                 


Lys Leu Asn Ile Ser Asp Gln Pro Arg Gln Leu Tyr Gly Gln Leu Pro 
385                 390                 395                 400 


Lys Asp Phe Phe Lys Gln Asp Asn Leu Ser Tyr His Leu Lys Ser Ile 
                405                 410                 415     


Thr Asp Gln Phe Arg Gly Thr Val Val Val Val Ile Gly Thr Glu Glu 
            420                 425                 430         


Asn Ile Asp Arg Ala Tyr Val Thr Ile Lys Lys Glu Phe Gly Gly Lys 
        435                 440                 445             


Glu Asp Leu Met Thr Gln Phe Val Gly Phe Thr Ser Ser Leu Val Thr 
    450                 455                 460                 


Glu Asn Asn Ile Phe His Tyr Tyr Asn Ile Leu Leu Gly Ile Tyr Ala 
465                 470                 475                 480 


Lys Ala Gly Val Gln Pro Trp Ile Leu Ala Ser Pro Met His Ser Asp 
                485                 490                 495     


Cys Phe Ile Gly Leu Asp Val Ser His Glu His Gly Lys His Ala Ser 
            500                 505                 510         


Gly Ile Ile Gln Val Ile Gly Arg Asp Gly Lys Ile Ile Lys Gln Lys 
        515                 520                 525             


Ser Val Ala Thr Ala Glu Ala Gly Glu Thr Ile Ala Asn Ser Thr Met 
    530                 535                 540                 


Glu Glu Ile Val Asn Glu Ser Ile Tyr Ser Tyr Glu Gln Ile Tyr Gly 
545                 550                 555                 560 


Ala Lys Pro Arg His Ile Thr Phe His Arg Asp Gly Ile Cys Arg Glu 
                565                 570                 575     


Asp Leu Asp Phe Leu Gln Ala Tyr Leu Arg Ser Phe Gln Ile Pro Phe 
            580                 585                 590         


Asp Phe Val Glu Ile Ile Lys Lys Pro Arg Arg Arg Met Ala Ile Tyr 
        595                 600                 605             


Ser Asn Lys Lys Trp Val Thr Lys Gln Gly Ile Tyr Tyr Ser Lys Gly 
    610                 615                 620                 


Asn Thr Ala Tyr Leu Cys Ala Thr Asp Pro Arg Glu Ser Val Gly Met 
625                 630                 635                 640 


Ala Gln Leu Val Lys Ile Val Gln Lys Thr Asn Gly Leu Ser Val His 
                645                 650                 655     


Glu Ile Val Ser Asp Val Tyr Lys Leu Ser Phe Met His Ile His Ser 
            660                 665                 670         


Met Leu Lys Thr Arg Leu Pro Ile Thr Ile His Tyr Ser Asp Leu Ser 
        675                 680                 685             


Ser Thr Phe His Asn Arg Gly Leu Ile His Pro Arg Ser Gln His Glu 
    690                 695                 700                 


Arg Ala Leu Pro Phe Val 
705                 710 


<210>  27
<211>  710
<212>  PRT
<213>  Geobacillus thermoleovorans CCB_US3_UF5


<220>
<221>  misc_feature
<223>  UniProt ID No: G8N378

<400>  27

Met Asn His Tyr Tyr Phe Ser Glu Cys Lys Ala Asp Glu Lys Ala Ser 
1               5                   10                  15      


Asp Ile Ala Ile His Leu Tyr Thr Val Pro Leu Ser Asn Pro His Glu 
            20                  25                  30          


Lys Tyr Ser Tyr Ala His Ser Ile Ala Tyr Glu Leu Arg Lys Leu Asn 
        35                  40                  45              


Ser Tyr Ile Thr Val Ala Ala His Gly Gln Tyr Ile Ala Ser Phe Glu 
    50                  55                  60                  


Glu Ile Cys His Trp Gly Asp His Arg Tyr Ile Gln His Glu His Arg 
65                  70                  75                  80  


Pro Ile Gln Cys Ser Leu Pro Met Glu Arg Thr Ile Leu Glu Arg Leu 
                85                  90                  95      


Leu Lys Lys Glu Leu Glu Asn Arg Cys Lys Ser Ser Tyr Lys Met Asp 
            100                 105                 110         


Asn Asp Leu Phe Arg Leu Ala Asn Glu Gln Ser Met His Val Gly Glu 
        115                 120                 125             


Ile Ser Ile His Pro Ala Ile Tyr Ile Ser Phe Ser Val Glu Glu Asn 
    130                 135                 140                 


Gly Asp Ile Phe Val Gly Phe Asp Tyr Gln His Arg Phe Glu Tyr Arg 
145                 150                 155                 160 


Lys Thr Leu Gln Asp Val Ile Asn Asn Asp Pro Ser Leu Leu Lys Glu 
                165                 170                 175     


Gly Met Glu Val Val Asp Pro Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr 
            180                 185                 190         


Phe Val Gly Met Ala Asp Tyr Thr Ala Gly Gln Lys Ser Pro Phe Leu 
        195                 200                 205             


Gln Gln Ser Val Ile Asp Tyr Tyr Leu Glu Lys Asn Glu Leu Trp Lys 
    210                 215                 220                 


Leu Lys Gly Val His Glu Lys Thr Pro Val Val His Val Lys Ser Arg 
225                 230                 235                 240 


Asp Gly His Leu Leu Pro Tyr Leu Pro His Leu Leu Lys Leu Thr Cys 
                245                 250                 255     


Ser Tyr Glu Gln Leu Leu Pro Ser Met Thr Lys Glu Val Asn Arg Leu 
            260                 265                 270         


Ile Lys Leu Ser Pro Asn Glu Lys Met Ser Lys Leu Tyr Thr Glu Met 
        275                 280                 285             


Phe Arg Leu Leu Arg Gln Gln Gln Val Leu Thr Phe Lys Lys Glu Asn 
    290                 295                 300                 


Val Arg Ala Val Asn Leu Gly Tyr Asp Val Asn Glu Leu Asp Ser Pro 
305                 310                 315                 320 


Ile Met Glu Phe Gly Gln Gly Tyr Lys Thr Asn Glu Ile Tyr Arg Gly 
                325                 330                 335     


Leu Lys Gln Ser Gly Val Tyr Glu Pro Ser Ser Val Ala Val Ser Phe 
            340                 345                 350         


Phe Val Asp Pro Glu Leu Asn Tyr Asp Pro Gln Lys Arg Lys Glu Val 
        355                 360                 365             


Gly Cys Phe Val Lys Lys Leu Glu Ser Met Ser Glu Ala Leu Gly Val 
    370                 375                 380                 


Lys Leu Asn Ile Ser Asp Gln Pro Arg Gln Leu Tyr Gly Gln Leu Pro 
385                 390                 395                 400 


Lys Asp Phe Phe Met Gln Asp Asn Leu Ser Tyr His Leu Lys Ser Ile 
                405                 410                 415     


Thr Asp Gln Phe Arg Gly Thr Val Val Val Val Ile Gly Thr Glu Glu 
            420                 425                 430         


Asn Ile Asp Arg Ala Tyr Val Thr Ile Lys Lys Glu Phe Gly Gly Lys 
        435                 440                 445             


Glu Asp Leu Met Thr Gln Phe Val Gly Phe Thr Ser Ser Leu Val Thr 
    450                 455                 460                 


Glu Asn Asn Ile Phe His Tyr Tyr Asn Ile Leu Leu Gly Ile Tyr Ala 
465                 470                 475                 480 


Lys Ala Gly Val Gln Pro Trp Ile Leu Ala Ser Pro Met His Ser Asp 
                485                 490                 495     


Cys Phe Ile Gly Leu Asp Val Ser His Glu His Gly Lys His Ala Ser 
            500                 505                 510         


Gly Ile Ile Gln Val Ile Gly Arg Asp Gly Lys Ile Ile Lys Gln Lys 
        515                 520                 525             


Ser Val Ala Thr Ala Glu Ala Gly Glu Thr Ile Ala Asn Ser Thr Met 
    530                 535                 540                 


Glu Glu Ile Val Asn Glu Ser Ile Tyr Ser Tyr Glu Gln Ile Tyr Gly 
545                 550                 555                 560 


Ala Lys Pro Arg His Ile Thr Phe His Arg Asp Gly Ile Cys Arg Glu 
                565                 570                 575     


Asp Leu Asp Phe Leu Gln Ala Tyr Leu Arg Ser Phe Gln Ile Pro Phe 
            580                 585                 590         


Asp Phe Val Glu Ile Ile Lys Lys Pro Arg Arg Arg Met Ala Ile Tyr 
        595                 600                 605             


Ser Asn Lys Lys Trp Val Thr Lys Gln Gly Ile Tyr Tyr Ser Lys Gly 
    610                 615                 620                 


Asn Thr Ala Tyr Leu Cys Ala Thr Asp Pro Arg Glu Ser Val Gly Met 
625                 630                 635                 640 


Ala Gln Leu Val Lys Ile Val Gln Lys Thr Asn Gly Leu Ser Val His 
                645                 650                 655     


Glu Ile Val Ser Asp Val Tyr Lys Leu Ser Phe Met His Ile His Ser 
            660                 665                 670         


Met Leu Lys Thr Arg Leu Pro Ile Thr Ile His Tyr Ser Asp Leu Ser 
        675                 680                 685             


Ser Thr Phe His Asn Arg Gly Leu Ile His Pro Arg Ser Gln His Glu 
    690                 695                 700                 


Arg Ala Leu Pro Phe Val 
705                 710 


<210>  28
<211>  559
<212>  PRT
<213>  Geobacillus stearothermophilus


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A161SXW4

<400>  28

Met Ser Ala Asp Thr Gln Leu Ala Pro Arg Val Leu Gln Asp Phe Ile 
1               5                   10                  15      


Asp Thr Asp Pro Ser Leu Leu Lys Glu Gly Met Glu Val Val Asp Pro 
            20                  25                  30          


Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr Phe Val Glu Ile Ala Asp Tyr 
        35                  40                  45              


Thr Ala Gly Gln Lys Ser Pro Phe Leu Gln Gln Ser Val Ile Asp Tyr 
    50                  55                  60                  


Tyr Leu Glu Lys Asn Glu Arg Trp Lys Leu Lys Ser Val His Glu Lys 
65                  70                  75                  80  


Thr Pro Val Val His Val Lys Ser Arg Asp Gly His Leu Leu Pro Tyr 
                85                  90                  95      


Leu Pro His Leu Leu Lys Leu Thr Cys Ser Tyr Glu Gln Leu Pro Pro 
            100                 105                 110         


Ser Met Met Lys Lys Val Asn Arg Leu Ile Lys Leu Ser Pro Asn Glu 
        115                 120                 125             


Lys Met Ser Lys Leu Tyr Thr Glu Thr Phe Arg Leu Leu Arg Gln Gln 
    130                 135                 140                 


Gln Val Leu Thr Phe Lys Lys Glu Asn Val Arg Ala Val Asn Leu Gly 
145                 150                 155                 160 


Tyr Asp Val Asn Glu Leu Asp Ser Pro Ile Met Glu Phe Gly Gln Gly 
                165                 170                 175     


Tyr Lys Thr Asn Glu Ile Tyr Arg Gly Leu Lys Gln Ser Gly Val Tyr 
            180                 185                 190         


Glu Pro Ser Ser Val Ala Val Ser Phe Phe Val Asp Pro Glu Leu Asn 
        195                 200                 205             


Tyr Asp Pro Gln Lys Arg Lys Glu Val Gly Tyr Phe Val Lys Lys Leu 
    210                 215                 220                 


Glu Ser Met Ser Glu Val Leu Gly Val Lys Leu Asn Ile Ser Asp Gln 
225                 230                 235                 240 


Pro Arg Gln Leu Tyr Gly Gln Leu Pro Lys Asp Phe Phe Lys Gln Asp 
                245                 250                 255     


Asn Leu Ser Tyr His Leu Lys Ser Ile Thr Asp Gln Phe Arg Gly Thr 
            260                 265                 270         


Val Val Val Val Ile Gly Thr Glu Glu Asn Ile Asp Arg Ala Tyr Val 
        275                 280                 285             


Thr Ile Lys Lys Glu Phe Gly Gly Lys Glu Asp Leu Met Thr Gln Phe 
    290                 295                 300                 


Val Gly Phe Thr Ser Ser Leu Val Thr Glu Asn Asn Ile Phe His Tyr 
305                 310                 315                 320 


Tyr Asn Ile Leu Leu Gly Ile Tyr Ala Lys Ala Gly Ile Gln Pro Trp 
                325                 330                 335     


Ile Leu Ala Ser Pro Met His Ser Asp Cys Phe Ile Gly Leu Asp Val 
            340                 345                 350         


Ser His Glu His Gly Lys His Val Ser Gly Ile Ile Gln Val Ile Gly 
        355                 360                 365             


Arg Asp Gly Lys Ile Ile Lys Gln Lys Ser Val Ala Thr Ala Glu Ala 
    370                 375                 380                 


Gly Glu Thr Ile Ala Asn Ser Thr Met Glu Glu Ile Val Asn Glu Ser 
385                 390                 395                 400 


Ile Tyr Ser Tyr Glu Gln Ile Tyr Gly Ala Lys Pro Arg His Ile Thr 
                405                 410                 415     


Phe His Arg Asp Gly Ile Cys Arg Glu Asp Leu Asp Phe Leu Gln Ala 
            420                 425                 430         


Tyr Leu Arg Ser Phe Gln Ile Pro Phe Asp Phe Val Glu Ile Ile Lys 
        435                 440                 445             


Lys Pro Arg Arg Arg Met Ala Ile Tyr Ser Asn Lys Lys Trp Val Thr 
    450                 455                 460                 


Lys Gln Gly Ile Tyr Tyr Ser Lys Gly Asn Thr Ala Tyr Leu Cys Ala 
465                 470                 475                 480 


Thr Asp Pro Lys Glu Phe Val Gly Met Ala Gln Leu Val Lys Ile Val 
                485                 490                 495     


Gln Lys Thr Asn Gly Leu Ser Val His Glu Ile Val Ser Asp Val Tyr 
            500                 505                 510         


Lys Leu Ser Phe Met His Ile His Ser Met Leu Lys Thr Arg Leu Pro 
        515                 520                 525             


Ile Thr Ile Tyr Tyr Ala Asp Leu Ser Ser Thr Phe His Asn Arg Gly 
    530                 535                 540                 


Leu Ile His Pro Arg Ser Gln His Glu Arg Ala Leu Pro Phe Val 
545                 550                 555                 


<210>  29
<211>  89
<212>  PRT
<213>  Paenibacillus borealis


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A089L658_ region of the PIWI domain from 601 to 
       700

<400>  29

Pro Leu Ser Ser Asp Cys Phe Ile Gly Leu Asp Val Ser His Glu Ala 
1               5                   10                  15      


Gly Arg His Ser Thr Gly Ile Val Gln Val Val Gly Lys Asp Gly Arg 
            20                  25                  30          


Val Leu Ser Ser Lys Ala Asn Thr Ser Asn Glu Ala Gly Glu Lys Ile 
        35                  40                  45              


Arg His Glu Thr Met Cys Gln Ile Val Tyr Ser Ala Ile Asp Gln Tyr 
    50                  55                  60                  


Gln Gln His Tyr Asn Glu Arg Pro Lys His Val Thr Phe His Arg Asp 
65                  70                  75                  80  


Gly Phe Cys Arg Glu Asp Leu Leu Ser 
                85                  


<210>  30
<211>  91
<212>  PRT
<213>  Lyngbya confervoides BDU141951


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A0C1VHB4_region of the PIWI domain from 601 to 
       700

<400>  30

Ala Asp Pro Gln Ala Ala Asp Leu Cys Ile Gly Phe Asp Ala Gly Thr 
1               5                   10                  15      


Asn Lys Lys Leu Phe Tyr Gly Thr Ser Ala Phe Ala Val Leu Ala Asn 
            20                  25                  30          


Gly Gln Ser Leu Gly Trp Glu Ile Pro Glu Ala Gln Leu Gly Glu Ser 
        35                  40                  45              


Phe Ser Ser Gln Ala Ile Trp Glu Ala Thr Ser Ser Ile Val Glu Arg 
    50                  55                  60                  


Phe Tyr Arg Leu Asn Asn Arg Asn Pro Gly Arg Ile Phe Leu Leu Arg 
65                  70                  75                  80  


Asp Gly Phe Val Arg Asp Gln Glu Phe Asp Tyr 
                85                  90      


<210>  31
<211>  88
<212>  PRT
<213>  Pseudoalteromonas piscicida


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A0F4NXW8_region of the PIWI domain from 601 to 
       700

<400>  31

Pro Gly Gln Ala Asp Leu Phe Ile Gly Leu Asp Met Gly Gly Thr His 
1               5                   10                  15      


Leu Arg Phe Pro Gly Val Ser Phe Leu Phe Ser Ala Thr Gly Ala Gln 
            20                  25                  30          


Leu Gly Trp Gln Ile Ala Asp Ser Gln Gln Gly Glu Lys Leu Lys Glu 
        35                  40                  45              


Asn Ala Leu Thr Asp Leu Leu Tyr Lys Cys Leu Arg Asn Tyr Ala Gln 
    50                  55                  60                  


Thr His Asn Gly Asn Lys Pro Lys His Ile Val Leu His Arg Asp Gly 
65                  70                  75                  80  


Lys Phe Tyr Glu Asp Leu Gly Gln 
                85              


<210>  32
<211>  88
<212>  PRT
<213>  Prochlorothrix hollandica PCC 9006 = CALU 1027.


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A0M2PXX3_ region of the PIWI domain from 601 to 
       700

<400>  32

Pro Gly Thr Ala Gln Ala Phe Val Gly Leu Asp Leu Gly Thr Lys Glu 
1               5                   10                  15      


Gly Arg Thr Val Gly Ala Ser Ala Phe Val Val Asp Ala His Gly Gln 
            20                  25                  30          


Val Ile Gly Trp Ser Ser Val Ser Leu Gln Thr Gly Glu Thr Phe Ser 
        35                  40                  45              


Asp Asp Ser Leu Arg Gln Ile Leu Arg Gly Leu Phe Gln Glu Phe Glu 
    50                  55                  60                  


Leu Arg Thr Gly Asn Pro Leu Glu His Leu Val Ile His Arg Asp Gly 
65                  70                  75                  80  


Thr Phe Lys Thr Arg Glu Leu Ala 
                85              


<210>  33
<211>  88
<212>  PRT
<213>  Marinobacter sp. T13-3


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A139DLI2_region of the PIWI domain from 601 to 
       700

<400>  33

Pro Gly Glu Val Asp Leu Phe Ile Gly Leu Asp Leu Gly Gly Val Ser 
1               5                   10                  15      


Gln Arg Ala Pro Gly Ser Ala Phe Leu Phe Thr Arg Asn Gly Ala Gln 
            20                  25                  30          


Leu Gly Trp Gln Leu Ala Asp Leu Gln Ser Gly Glu Arg Leu Glu Asp 
        35                  40                  45              


Lys Ala Leu Lys Ser Leu Leu His Lys Ser Ile Gln Glu Tyr Gly Arg 
    50                  55                  60                  


His His Asn Gly Glu Pro Pro Arg Thr Met Thr Ile His Arg Asp Gly 
65                  70                  75                  80  


Arg Phe Phe Glu Ser Leu Asp Val 
                85              


<210>  34
<211>  91
<212>  PRT
<213>  Stanieria sp. NIES-3757


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A140KBY4_ region of the PIWI domain from 601 to 
       700

<400>  34

Pro Asn Glu Tyr Ala Ala Glu Leu Val Ile Gly Phe Asp Ala Gly Thr 
1               5                   10                  15      


Asn Arg Ser Leu Tyr Tyr Gly Thr Ser Ala Phe Ala Ile Leu Ala Asn 
            20                  25                  30          


Gly Gln Ser Leu Gly Trp Glu Leu Pro Glu Ala Gln Pro Gly Glu Lys 
        35                  40                  45              


Leu Ser Gly Gln Ala Val Leu Arg Thr Val Ala His Leu Ile His Arg 
    50                  55                  60                  


Phe Gln Arg Ile Glu Asn Arg Leu Pro Lys Arg Ile Leu Leu Leu Arg 
65                  70                  75                  80  


Asp Gly Ile Val Gln Arg Asp Glu Phe Ala Ser 
                85                  90      


<210>  35
<211>  89
<212>  PRT
<213>  Planococcus maritimus


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A150W6E9_ region of the PIWI domain from 601 to 
       700

<400>  35

Lys Thr Asn Ser Asp Cys Phe Ile Gly Leu Asp Val Ser His Glu Lys 
1               5                   10                  15      


Gly Arg Ser Thr Ala Gly Ile Ile Asn Val Ile Gly Asn Asp Gly Arg 
            20                  25                  30          


Leu Ile Lys Gln Ser Ala Val Gly Gly Ala Asn Ala Gly Glu Lys Val 
        35                  40                  45              


Ser Asp Glu Leu Leu Lys Asp Thr Leu Asn Glu Val Leu His Lys Tyr 
    50                  55                  60                  


Lys Val Gln Phe Asp Glu Leu Pro Lys His Val Thr Ile His Arg Asp 
65                  70                  75                  80  


Gly Phe Trp Arg Glu Asn Thr Glu Leu 
                85                  


<210>  36
<211>  90
<212>  PRT
<213>  Dorea longicatena


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A174GIW5_ region of the PIWI domain from 601 to 
       700

<400>  36

Pro Gly Asn Val Asp Cys Phe Val Gly Leu Asp Val Ala Ile Leu Glu 
1               5                   10                  15      


Lys Gly Ile His Tyr Pro Ala Cys Ser Val Val Phe Asp Lys Ser Gly 
            20                  25                  30          


Arg Leu Leu Gly Phe Tyr Lys Pro Lys Ser Ala Gln Arg Gly Glu Lys 
        35                  40                  45              


Ile Glu Thr Arg Ile Leu Gln Asp Ile Phe Asp Gln Val Leu Leu Ser 
    50                  55                  60                  


Tyr Glu Glu Lys Phe Gly Glu Gln Pro Lys Asn Ile Met Ile His Arg 
65                  70                  75                  80  


Asp Gly Phe Ser Asn Glu Asn Asp Ala Trp 
                85                  90  


<210>  37
<211>  89
<212>  PRT
<213>  Intestinibacter bartlettii


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A174GM97_ region of the PIWI domain from 601 to 
       700

<400>  37

Gly Leu Ser Ala Asp Cys Tyr Ile Gly Leu Asp Val Cys Arg Glu Asn 
1               5                   10                  15      


Asn Met Ser Thr Ala Gly Leu Ile Gln Val Ile Gly Lys Asp Gly Arg 
            20                  25                  30          


Val Leu Lys Ser Lys Thr Ile Ser Ser His Gln Ser Gly Glu Lys Ile 
        35                  40                  45              


Gln Ile Asn Ile Leu Lys Asp Ile Ile Phe Glu Ala Lys Gln Ala Tyr 
    50                  55                  60                  


Lys Asn Thr Tyr Asn Lys Lys Leu Glu His Ile Val Phe His Arg Asp 
65                  70                  75                  80  


Gly Ile Asn Arg Glu Asp Ile Asp Leu 
                85                  


<210>  38
<211>  90
<212>  PRT
<213>  Fusicatenibacter saccharivorans


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A174T2R9_ region of the PIWI domain from 601 to 
       700

<400>  38

Pro Gly Asn Val Asp Cys Phe Val Gly Leu Asp Val Ala Thr Ile Ala 
1               5                   10                  15      


Lys Gly Ile His Tyr Pro Ala Cys Ser Val Val Phe Asp Lys Tyr Gly 
            20                  25                  30          


Arg Leu Leu Gly Phe Tyr Lys Pro Ala Ala Pro Gln Gln Gly Glu Lys 
        35                  40                  45              


Ile Thr Thr Arg Ile Leu Gln Asp Ile Phe Asp Gln Val Ile Phe Ala 
    50                  55                  60                  


Tyr Glu Asp Arg Phe Gly Glu Met Pro Lys Asn Ile Val Ile His Arg 
65                  70                  75                  80  


Asp Gly Phe Ser Asn Glu Asp Asp Glu Trp 
                85                  90  


<210>  39
<211>  88
<212>  PRT
<213>  Methylomonas koyamae


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A177NTC0_region of the PIWI domain from 601 to 
       700

<400>  39

Pro Gly Glu Thr Asp Leu Phe Ile Gly Leu Asp Met Gly Gly Val Asn 
1               5                   10                  15      


Val Arg Ala Pro Gly Phe Ala Phe Leu Phe Leu Ser Ser Gly Thr Gln 
            20                  25                  30          


Leu Gly Trp Gln Leu Ala Asp Lys Gln Gln Gly Glu Arg Met Gln Asp 
        35                  40                  45              


Glu Ala Leu Met Asn Leu Leu Glu Lys Ser Leu Lys Thr Tyr Leu Arg 
    50                  55                  60                  


Ser Ser Asp Gly Val Leu Pro Arg Arg Ile Thr Leu His Arg Asp Gly 
65                  70                  75                  80  


Lys Phe Tyr Glu Ser Ile Asp Val 
                85              


<210>  40
<211>  88
<212>  PRT
<213>  Limnothrix sp. P13C2


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A1C0UUC4_ region of the PIWI domain from 601 to 
       700

<400>  40

Pro Gly Thr Ala Gln Ala Phe Val Gly Leu Asp Leu Gly Arg Lys Glu 
1               5                   10                  15      


Glu Arg Thr Ile Gly Ala Ser Ala Phe Val Val Asn Arg Gln Gly Gln 
            20                  25                  30          


Ala Ile Gly Trp Ser Ser Ala Ser Met Gln Arg Gly Glu Thr Phe Ser 
        35                  40                  45              


Glu Thr Ser Leu Arg Asn Ile Leu Leu Asp Leu Phe Gly Ala Phe Thr 
    50                  55                  60                  


Glu Gln Ser Gly Glu Pro Leu Arg His Val Val Ile His Arg Asp Gly 
65                  70                  75                  80  


Thr Val Lys Asn Ser Glu Leu Ala 
                85              


<210>  41
<211>  87
<212>  PRT
<213>  Lyngbya sp. (strain PCC 8106) (Lyngbya aestuarii (strain CCY9616))


<220>
<221>  misc_feature
<223>  UniProt ID No: A0YYT3_ region of the PIWI domain from 601 to 700

<400>  41

Leu Glu Ile Ala Asp Tyr Phe Ile Gly Leu Asp Ile Ser Arg Thr Pro 
1               5                   10                  15      


Lys Lys Arg Lys Ser Gly Ser Leu Asn Val Cys Ala Ser Val Arg Leu 
            20                  25                  30          


Tyr Gly Lys Tyr Gly Glu Phe Ile Arg Tyr Arg Leu Glu Asp Ala Leu 
        35                  40                  45              


Thr Gln Gly Glu Glu Ile Asp Lys Arg Thr Leu Glu Arg Phe Leu Pro 
    50                  55                  60                  


Ala Ala Asp Leu Ser Gly Lys Thr Val Leu Ile Tyr Arg Asp Gly Arg 
65                  70                  75                  80  


Phe Cys Gly Asp Glu Ile Lys 
                85          


<210>  42
<211>  89
<212>  PRT
<213>  Intestinibacter bartlettii DSM 16795


<220>
<221>  misc_feature
<223>  UniProt ID No: B0ADC8_ region of the PIWI domain from 601 to 700

<400>  42

Gly Leu Ser Ala Asp Cys Tyr Ile Gly Leu Asp Val Cys Arg Glu Asn 
1               5                   10                  15      


Asn Met Ser Thr Ala Gly Leu Ile Gln Val Ile Gly Lys Asp Gly Arg 
            20                  25                  30          


Val Leu Lys Ser Lys Thr Ile Ser Ser His Gln Ser Gly Glu Lys Ile 
        35                  40                  45              


Gln Ile Asn Ile Leu Lys Asp Ile Ile Phe Glu Ala Lys Gln Ala Tyr 
    50                  55                  60                  


Lys Asn Thr Tyr Asn Lys Lys Leu Glu His Ile Val Phe His Arg Asp 
65                  70                  75                  80  


Gly Ile Asn Arg Glu Asp Ile Asp Leu 
                85                  


<210>  43
<211>  90
<212>  PRT
<213>  Halarchaeum acidiphilum MH1-52-1


<220>
<221>  misc_feature
<223>  UniProt ID No: U3A1K8_ region of the PIWI domain from 601 to 700

<400>  43

Pro Gly Glu Thr Asp Ala Phe Met Gly Leu Asp Val Ser His Asp Gln 
1               5                   10                  15      


Ser Ser Asp Lys His Thr Gly Ala Ser Ala Ser Val Val Leu Ser Asp 
            20                  25                  30          


Gly Thr Thr Tyr Ala Ala Glu Ser Thr Val Gly Gln Ser Gly Glu Thr 
        35                  40                  45              


Phe Ser Ala Glu His Val Gln Gln Phe Val Arg Asp Leu Val Phe Asp 
    50                  55                  60                  


Phe Ala Met Glu Gln Gly Thr Glu Ile Asn Arg Leu Cys Ile Met Arg 
65                  70                  75                  80  


Asp Gly Lys Ile Ser Glu Asp Ile Asp Ala 
                85                  90  


<210>  44
<211>  89
<212>  PRT
<213>  Bacillus sp. (strain JF8)


<220>
<221>  misc_feature
<223>  UniProt ID No: S5Z517_ region of the PIWI domain from 601 to 700

<400>  44

Pro Met His Ser Asp Cys Phe Ile Gly Leu Asp Val Ser His Glu Tyr 
1               5                   10                  15      


Gly Lys His Ala Ser Gly Ile Ile Gln Val Ile Gly Arg Asp Gly Lys 
            20                  25                  30          


Ile Ile Lys Gln Lys Leu Val Ala Thr Ala Glu Ala Gly Glu Ile Ile 
        35                  40                  45              


Ala Asn Ser Thr Met Glu Glu Ile Val Asn Glu Ser Ile Tyr Ser Tyr 
    50                  55                  60                  


Glu Gln Thr Tyr Gly Ala Lys Pro Arg His Ile Thr Phe His Arg Asp 
65                  70                  75                  80  


Gly Ile Cys Arg Glu Asp Leu Asp Phe 
                85                  


<210>  45
<211>  89
<212>  PRT
<213>  Clostridium sp. CAG:265


<220>
<221>  misc_feature
<223>  UniProt ID No: R6KUL9_ region of the PIWI domain from 601 to 700

<400>  45

Lys Leu Asn Ser Asp Cys Phe Ile Gly Leu Asp Val Ser Arg Glu Asn 
1               5                   10                  15      


Lys Val Asn Lys Ala Gly Val Ile Gln Val Val Gly Lys Asp Gly Lys 
            20                  25                  30          


Val Leu Lys Thr Lys Val Ile Ser Ala Ser Gln Ser Gly Glu Lys Ile 
        35                  40                  45              


Lys Leu Glu Thr Leu Lys Glu Ile Val Phe Glu Ala Val Gly Ser Tyr 
    50                  55                  60                  


Glu Asn Ala Tyr Gly Cys Arg Pro Lys His Ile Thr Phe His Arg Asp 
65                  70                  75                  80  


Gly Ile Ser Arg Glu Glu Leu Glu Asn 
                85                  


<210>  46
<211>  90
<212>  PRT
<213>  Eubacterium sp. CAG:603


<220>
<221>  misc_feature
<223>  UniProt ID No: R5NJJ8_ region of the PIWI domain from 601 to 700

<400>  46

Pro Gly Asn Val Asp Cys Phe Val Gly Leu Asp Val Ala Thr Val Ala 
1               5                   10                  15      


Lys Gly Ile His Tyr Pro Ala Cys Ser Val Val Phe Asp Lys Tyr Gly 
            20                  25                  30          


Arg Leu Leu Gly Phe Tyr Lys Pro Thr Thr Pro Gln Gln Gly Glu Lys 
        35                  40                  45              


Ile Thr Thr Arg Ile Leu Gln Asp Ile Phe Asp Gln Val Ile Phe Ser 
    50                  55                  60                  


Tyr Glu Asp Arg Phe Glu Glu Met Pro Lys Asn Val Val Ile His Arg 
65                  70                  75                  80  


Asp Gly Phe Ser Asn Glu Asn Asp Asp Trp 
                85                  90  


<210>  47
<211>  91
<212>  PRT
<213>  Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)


<220>
<221>  misc_feature
<223>  UniProt ID No: Q746M7_ region of the PIWI domain from 601 to 700

<400>  47

Ser Gly Ala Tyr Pro Ala Glu Leu Ala Val Gly Phe Asp Ala Gly Gly 
1               5                   10                  15      


Arg Glu Ser Phe Arg Phe Gly Gly Ala Ala Cys Ala Val Gly Gly Asp 
            20                  25                  30          


Gly Gly His Leu Leu Trp Thr Leu Pro Glu Ala Gln Ala Gly Glu Arg 
        35                  40                  45              


Ile Pro Gln Glu Val Val Trp Asp Leu Leu Glu Glu Thr Leu Trp Ala 
    50                  55                  60                  


Phe Arg Arg Lys Ala Gly Arg Leu Pro Ser Arg Val Leu Leu Leu Arg 
65                  70                  75                  80  


Asp Gly Arg Val Pro Gln Asp Glu Phe Ala Leu 
                85                  90      


<210>  48
<211>  91
<212>  PRT
<213>  Stanieria cyanosphaera (strain ATCC 29371 / PCC 7437)


<220>
<221>  misc_feature
<223>  UniProt ID No: K9XZC6_ region of the PIWI domain from 601 to 700

<400>  48

Gln Asp Glu Tyr Ala Ala Glu Leu Val Ile Gly Phe Asp Ala Gly Thr 
1               5                   10                  15      


Asn Arg Asn Leu Tyr Tyr Gly Thr Ser Ala Phe Ala Ile Leu Ala Asn 
            20                  25                  30          


Gly Gln Ser Leu Gly Trp Glu Leu Pro Glu Ala Gln Pro Gly Glu Lys 
        35                  40                  45              


Leu Ser Gly Gln Ala Val Leu Asn Thr Val Ala Asn Ile Ile Asn Arg 
    50                  55                  60                  


Phe Gln Arg Ile Glu Asn Arg Leu Pro Lys Arg Ile Leu Leu Leu Arg 
65                  70                  75                  80  


Asp Gly Ile Val Gln Arg Asp Glu Phe Glu Ser 
                85                  90      


<210>  49
<211>  91
<212>  PRT
<213>  Pyrococcus furiosus COM1


<220>
<221>  misc_feature
<223>  UniProt ID: I6U616_ region of the PIWI domain from 601 to 700

<400>  49

Arg Phe Asn Tyr Asp Tyr Ile Ile Gly Ile Asp Val Ala Pro Met Lys 
1               5                   10                  15      


Arg Ser Glu Gly Tyr Ile Gly Gly Ser Ala Val Met Phe Asp Ser Gln 
            20                  25                  30          


Gly Tyr Ile Arg Lys Ile Val Pro Ile Lys Ile Gly Glu Gln Arg Gly 
        35                  40                  45              


Glu Ser Val Asp Met Asn Glu Phe Phe Lys Glu Met Val Asp Lys Phe 
    50                  55                  60                  


Lys Glu Phe Asn Ile Lys Leu Asp Asn Lys Lys Ile Leu Leu Leu Arg 
65                  70                  75                  80  


Asp Gly Arg Ile Thr Asn Asn Glu Glu Glu Gly 
                85                  90      


<210>  50
<211>  91
<212>  PRT
<213>  Cyanothece sp. (strain PCC 7822)


<220>
<221>  misc_feature
<223>  UniProt ID No: E0UCX3_ region of the PIWI domain from 601 to 700

<400>  50

Gln His Glu Gln Ala Ala Glu Leu Val Ile Gly Phe Asp Ala Gly Thr 
1               5                   10                  15      


Asn Arg Ser Leu Tyr Tyr Gly Thr Ser Ala Phe Ala Val Leu Ala Asn 
            20                  25                  30          


Gly Gln Ser Leu Gly Trp Glu Leu Pro Glu Ala Gln Pro Gly Glu Arg 
        35                  40                  45              


Leu Ser Gly Gln Ala Val Leu Arg Ala Thr Leu Asn Ile Val Asp Arg 
    50                  55                  60                  


Phe Gln Lys Leu Glu Lys Arg Pro Pro Lys Arg Leu Leu Leu Leu Arg 
65                  70                  75                  80  


Asp Gly Phe Val Gln Arg Asp Glu Phe Asp Ser 
                85                  90      


<210>  51
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus100_region of the PIWI domain from 601 to 700


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(88)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (92)..(100)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Asp Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Asn Val Cys Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Gly Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Asp Gly Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa 
            100 


<210>  52
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus80_region of the PIWI domain from 601 to 700


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(88)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (92)..(100)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Gly Xaa Asp Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Leu Asn Val Cys Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa 
        35                  40                  45              


Xaa Xaa Xaa Gln Xaa Gly Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Asp Gly Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa 
            100 


<210>  53
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus60_region of the PIWI domain from 601 to 700


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(81)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (83)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (92)..(100)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Xaa Xaa Xaa Tyr Ala Xaa Asp Xaa Phe Ile Gly Leu Asp Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Leu Asn Val Cys Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Leu Xaa Xaa Xaa Xaa Ile Xaa 
        35                  40                  45              


Xaa Xaa Xaa Gln Xaa Gly Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Pro Xaa Xaa Xaa Xaa Xaa His Arg Asp Gly Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa 
            100 


<210>  54
<211>  189
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD46 Exon 2

<400>  54
atgcctgtga ggagccacca acatttgaag ctatggagct cattggtaaa ccaaaaccct       60

actatgagat tggtgaacga gtagattata agtgtaaaaa aggatacttc tatatacctc      120

ctcttgccac ccatactatt tgtgatcgga atcatacatg gctacctgtc tcagatgacg      180

cctgttata                                                              189


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA1

<400>  55
aggatacttc tatatacctc c                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA2


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  56
aggatacttc tatatacctc c                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA3

<400>  57
ggaggtatat agaagtatcc t                                                 21


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA4


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  58
ggaggtatat agaagtatcc t                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA5

<400>  59
ctatttgtga tcggaatcat a                                                 21


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA6


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  60
ctatttgtga tcggaatcat a                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA7

<400>  61
tatgattccg atcacaaata g                                                 21


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  62
tatgattccg atcacaaata g                                                 21


<210>  63
<211>  198
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD46 Exon 5

<400>  63
aggttttgtg tacaccacct ccaaaaataa aaaatggaaa acacaccttt agtgaagtag       60

aagtatttga gtatcttgat gcagtaactt atagttgtga tcctgcacct ggaccagatc      120

cattttcact tattggagag agcacgattt attgtggtga caattcagtg tggagtcgtg      180

ctgctccaga gtgtaaag                                                    198


<210>  64
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA9

<400>  64
gtgaagtaga agtatttgag tatc                                              24


<210>  65
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA10


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  65
gtgaagtaga agtatttgag tatc                                              24


<210>  66
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA11

<400>  66
gatactcaaa tacttctact tcac                                              24


<210>  67
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA12


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  67
gatactcaaa tacttctact tcac                                              24


<210>  68
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA13

<400>  68
gttgtgatcc tgcacctgga ccag                                              24


<210>  69
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA14


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  69
gttgtgatcc tgcacctgga ccag                                              24


<210>  70
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA15

<400>  70
ctggtccagg tgcaggatca caac                                              24


<210>  71
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA16


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  71
ctggtccagg tgcaggatca caac                                              24


<210>  72
<211>  115
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD81 Exon 2

<400>  72
ctggctggag gcgtgatcct gggtgtggcc ctgtggctcc gccatgaccc gcagaccacc       60

aacctcctgt atctggagct gggagacaag cccgcgccca acaccttcta tgtag           115


<210>  73
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA17

<400>  73
cctgggtgtg gccctgtggc tccg                                              24


<210>  74
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA18


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  74
cctgggtgtg gccctgtggc tccg                                              24


<210>  75
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA19

<400>  75
cggagccaca gggccacacc cagg                                              24


<210>  76
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA20


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  76
cggagccaca gggccacacc cagg                                              24


<210>  77
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA21

<400>  77
caacctcctg tatctggagc tggg                                              24


<210>  78
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA22


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  78
caacctcctg tatctggagc tggg                                              24


<210>  79
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA23

<400>  79
cccagctcca gatacaggag gttg                                              24


<210>  80
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA24


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  80
cccagctcca gatacaggag gttg                                              24


<210>  81
<211>  98
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD81 Exon 3

<400>  81
gcatctacat cctcatcgct gtgggcgctg tcatgatgtt cgttggcttc ctgggctgct       60

acggggccat ccaggaatcc cagtgcctgc tggggacg                               98


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA25

<400>  82
ctgtcatgat gttcgttggc t                                                 21


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA26


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  83
ctgtcatgat gttcgttggc t                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA27

<400>  84
agccaacgaa catcatgaca g                                                 21


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA28


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  85
agccaacgaa catcatgaca g                                                 21


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA29

<400>  86
ggccatccag gaatcccagt g                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA30


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  87
ggccatccag gaatcccagt g                                                 21


<210>  88
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA31

<400>  88
cactgggatt cctggatggc c                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA32


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  89
cactgggatt cctggatggc c                                                 21


<210>  90
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA1


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  90
aggauacuuc uauauaccuc c                                                 21


<210>  91
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA2


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  91
ggagguauau agaaguaucc u                                                 21


<210>  92
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA3


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  92
cuauuuguga ucggaaucau a                                                 21


<210>  93
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA4


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  93
uaugauuccg aucacaaaua g                                                 21


<210>  94
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA5


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  94
gugaaguaga aguauuugag uauc                                              24


<210>  95
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA6


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  95
gauacucaaa uacuucuacu ucac                                              24


<210>  96
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA7


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  96
guugugaucc ugcaccugga ccag                                              24


<210>  97
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA8


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  97
cugguccagg ugcaggauca caac                                              24


<210>  98
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA9


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  98
ccugggugug gcccuguggc uccg                                              24


<210>  99
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA10


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  99
cggagccaca gggccacacc cagg                                              24


<210>  100
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA11


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  100
caaccuccug uaucuggagc uggg                                              24


<210>  101
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA12


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  101
cccagcucca gauacaggag guug                                              24


<210>  102
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA13


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  102
cugucaugau guucguuggc u                                                 21


<210>  103
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA14


<220>
<221>  misc_feature
<223>  5'end phopshorylated

<400>  103
agccaacgaa caucaugaca g                                                 21


<210>  104
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA15


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  104
ggccauccag gaaucccagu g                                                 21


<210>  105
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gRNA16


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  105
cacugggauu ccuggauggc c                                                 21


<210>  106
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN1

<400>  106
gattataagt gtaaaaaagg atacttctat atacctcctc ttgccaccca tactatttgt       60

gatcggaatc atacatggct acctgtctca gatgacgc                               98


<210>  107
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN2

<400>  107
gcgtcatctg agacaggtag ccatgtatga ttccgatcac aaatagtatg ggtggcaaga       60

ggaggtatat agaagtatcc ttttttacac ttataatc                               98


<210>  108
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN3

<400>  108
ggaaaacaca cctttagtga agtagaagta tttgagtatc ttgatgcagt aacttatagt       60

tgtgatcctg cacctggacc agatccattt tcacttattg gagag                      105


<210>  109
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN4

<400>  109
ctctccaata agtgaaaatg gatctggtcc aggtgcagga tcacaactat aagttactgc       60

atcaagatac tcaaatactt ctacttcact aaaggtgtgt tttcc                      105


<210>  110
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN5

<400>  110
ctggctggag gcgtgatcct gggtgtggcc ctgtggctcc gccatgaccc gcagaccacc       60

aacctcctgt atctggagct gggagacaag cccgcgccca ac                         102


<210>  111
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN6

<400>  111
gttgggcgcg ggcttgtctc ccagctccag atacaggagg ttggtggtct gcgggtcatg       60

gcggagccac agggccacac ccaggatcac gcctccagcc ag                         102


<210>  112
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN7

<400>  112
gcatctacat cctcatcgct gtgggcgctg tcatgatgtt cgttggcttc ctgggctgct       60

acggggccat ccaggaatcc cagtgcctgc tggggacg                               98


<210>  113
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN8

<400>  113
cgtccccagc aggcactggg attcctggat ggccccgtag cagcccagga agccaacgaa       60

catcatgaca gcgcccacag cgatgaggat gtagatgc                               98


<210>  114
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD46_exon2_fwd

<400>  114
ccaaacaaac caaaagctaa tagga                                             25


<210>  115
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD46_exon2_rev

<400>  115
acaagaagaa aatcatcatc accgt                                             25


<210>  116
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD46_exon5_fwd

<400>  116
tcacaaacag cttgtagaaa ccc                                               23


<210>  117
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD46_exon5_rev

<400>  117
gggtgagaaa tagggaactc tagc                                              24


<210>  118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD81_exon2_fwd

<400>  118
gagtcacact ccacaggtgc                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD81_exon2_rev

<400>  119
tccatctcaa cccttgtgcc                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD81_exon3_fwd

<400>  120
gcctccttag tctccgtcct                                                   20


<210>  121
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD81_exon3_rev

<400>  121
aaagcggtca cgtaggaact                                                   20


<210>  122
<211>  710
<212>  PRT
<213>  Geobacillus lituanicus


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A223DRY4

<400>  122

Met Asn His Tyr Tyr Phe Ser Glu Cys Lys Ala Asn Glu Lys Ala Ser 
1               5                   10                  15      


Asp Ile Pro Ile His Leu Tyr Thr Val Pro Leu Ser Asn Pro His Glu 
            20                  25                  30          


Lys Tyr Ser Tyr Ala His Ser Ile Ala Tyr Glu Leu Arg Lys Leu Asn 
        35                  40                  45              


Ser Tyr Ile Thr Val Val Ala His Gly Gln Tyr Ile Ala Ser Phe Glu 
    50                  55                  60                  


Glu Ile Cys His Trp Gly Asp His Arg Tyr Ile Gln His Glu His Arg 
65                  70                  75                  80  


Pro Ile Gln Cys Ser Leu Pro Met Glu Arg Thr Ile Leu Glu Lys Leu 
                85                  90                  95      


Leu Lys Lys Glu Leu Glu Asn Arg Cys Lys Ser Ser Tyr Lys Met Asp 
            100                 105                 110         


Asn Asp Leu Phe Arg Leu Ala Asn Glu Gln Ser Met His Val Gly Glu 
        115                 120                 125             


Ile Ser Ile His Pro Ala Ile Tyr Ile Ser Phe Ser Val Glu Glu Asn 
    130                 135                 140                 


Gly Asp Ile Phe Val Gly Phe Asp Tyr Gln His Arg Phe Glu Tyr Arg 
145                 150                 155                 160 


Lys Thr Leu Gln Asp Val Ile Asn Asn Asp Pro Ser Leu Leu Lys Glu 
                165                 170                 175     


Gly Met Glu Val Val Asp Leu Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr 
            180                 185                 190         


Phe Val Gly Met Ala Asp Tyr Thr Ala Gly Gln Lys Ser Pro Phe Leu 
        195                 200                 205             


Gln Gln Ser Val Ile Asp Tyr Tyr Leu Glu Lys Asn Glu Leu Trp Lys 
    210                 215                 220                 


Leu Lys Gly Val His Glu Lys Thr Pro Val Val His Val Lys Asn Arg 
225                 230                 235                 240 


Asp Gly His Leu Leu Pro Tyr Leu Pro His Leu Leu Lys Leu Thr Cys 
                245                 250                 255     


Ser Tyr Glu Gln Leu Pro Pro Ser Met Thr Lys Lys Val Asn Arg Leu 
            260                 265                 270         


Ile Lys Leu Ser Pro His Glu Lys Met Phe Lys Leu Tyr Thr Glu Ala 
        275                 280                 285             


Phe Arg Leu Leu Ser Gln Gln Gln Val Leu Thr Phe Gln Lys Glu Asn 
    290                 295                 300                 


Val Arg Ala Val Asn Leu Gly Tyr Asp Val Asn Glu Leu Asp Ser Pro 
305                 310                 315                 320 


Ile Met Glu Phe Gly Gln Gly Tyr Lys Thr Asn Glu Ile Tyr Arg Gly 
                325                 330                 335     


Leu Lys Gln Ser Gly Val Tyr Glu Pro Ser Asn Val Ala Val Ser Tyr 
            340                 345                 350         


Phe Val Asp Pro Glu Leu Asn Tyr Asp Pro Gln Lys Arg Lys Glu Val 
        355                 360                 365             


Gly Cys Phe Val Lys Lys Leu Glu Ser Met Ser Glu Ala Leu Gly Val 
    370                 375                 380                 


Lys Leu Asn Val Ser Asn Gln Pro Arg Gln Leu Tyr Gly Gln Leu Pro 
385                 390                 395                 400 


Lys Asp Phe Phe Lys Gln Asp Asn Leu Ser Tyr His Leu Lys Ser Ile 
                405                 410                 415     


Thr Asp Gln Phe Arg Gly Thr Val Val Val Val Ile Gly Thr Glu Glu 
            420                 425                 430         


Asn Ile Asp Arg Ala Tyr Val Thr Ile Lys Lys Glu Phe Gly Gly Lys 
        435                 440                 445             


Glu Asp Leu Met Thr Gln Phe Val Gly Phe Thr Ser Ser Leu Val Thr 
    450                 455                 460                 


Glu Asn Asn Ile Phe His Tyr Tyr Asn Ile Leu Leu Gly Ile Tyr Ala 
465                 470                 475                 480 


Lys Ala Gly Val Gln Pro Trp Ile Leu Ala Ser Pro Met His Ser Asp 
                485                 490                 495     


Cys Phe Ile Gly Leu Asp Val Ser His Glu His Gly Lys His Ala Ser 
            500                 505                 510         


Gly Ile Ile Gln Val Ile Gly Arg Asp Gly Lys Ile Ile Lys Gln Lys 
        515                 520                 525             


Ser Val Ala Thr Ala Glu Ala Gly Glu Thr Ile Ala Asn Ser Thr Met 
    530                 535                 540                 


Glu Glu Ile Val Asn Glu Ser Ile Tyr Ser Tyr Glu Gln Ile Tyr Gly 
545                 550                 555                 560 


Ala Lys Pro Arg His Ile Thr Phe His Arg Asp Gly Ile Cys Arg Glu 
                565                 570                 575     


Asp Leu Asp Phe Leu Gln Ala Tyr Leu Arg Ser Phe Gln Ile Pro Phe 
            580                 585                 590         


Asp Phe Val Glu Ile Ile Lys Lys Pro Arg Arg Arg Met Ala Ile Tyr 
        595                 600                 605             


Ser Asn Lys Lys Trp Val Thr Lys Gln Gly Ile Tyr Tyr Ser Lys Gly 
    610                 615                 620                 


Asn Thr Ala Tyr Leu Cys Ala Thr Asp Pro Arg Glu Ser Val Gly Met 
625                 630                 635                 640 


Ala Gln Leu Val Lys Ile Val Gln Lys Thr Asn Gly Leu Ser Val His 
                645                 650                 655     


Glu Ile Val Ser Asp Val Tyr Lys Leu Ser Phe Met His Ile His Ser 
            660                 665                 670         


Met Leu Lys Thr Arg Leu Pro Ile Thr Ile His Tyr Ser Asp Leu Ser 
        675                 680                 685             


Ser Thr Phe His Asn Arg Gly Leu Ile His Pro Arg Ser Gln His Glu 
    690                 695                 700                 


Arg Ala Leu Pro Phe Val 
705                 710 


<210>  123
<211>  710
<212>  PRT
<213>  Geobacillus thermoglucosidasius


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A1Y3PFV5

<400>  123

Met Asn His Tyr Tyr Phe Ser Glu Cys Lys Ala Asn Glu Lys Ala Ser 
1               5                   10                  15      


Asp Ile Ala Ile His Leu Tyr Thr Val Pro Leu Ser Asn Pro His Glu 
            20                  25                  30          


Lys Tyr Ser Tyr Ala His Ser Ile Ala Tyr Glu Leu Arg Lys Leu Asn 
        35                  40                  45              


Ser Tyr Ile Thr Val Ala Ala His Gly Gln Tyr Ile Ala Ser Phe Glu 
    50                  55                  60                  


Glu Ile Cys His Trp Gly Asp His Arg Tyr Ile Arg His Glu His Arg 
65                  70                  75                  80  


Pro Ile Gln Cys Ser Leu Pro Met Glu Arg Thr Ile Leu Glu Lys Leu 
                85                  90                  95      


Leu Lys Lys Glu Leu Glu Asn Arg Cys Lys Ser Gly Tyr Lys Met Asp 
            100                 105                 110         


Asn Asp Leu Phe Arg Leu Ala Asn Glu Gln Ser Met His Val Gly Glu 
        115                 120                 125             


Ile Ser Ile His Pro Val Ile Tyr Ile Ser Phe Ser Val Glu Glu Asn 
    130                 135                 140                 


Gly Asp Ile Phe Val Gly Phe Asp Tyr Gln His Arg Phe Glu Tyr Arg 
145                 150                 155                 160 


Lys Thr Leu Gln Asp Phe Ile Asp Thr Asp Pro Ser Leu Leu Lys Glu 
                165                 170                 175     


Gly Met Glu Val Val Asp Pro Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr 
            180                 185                 190         


Phe Val Glu Ile Ala Asp Tyr Thr Ala Gly Gln Lys Ser Pro Phe Leu 
        195                 200                 205             


Gln Gln Ser Val Ile Asp Tyr Tyr Leu Glu Lys Asn Glu Leu Trp Lys 
    210                 215                 220                 


Leu Lys Gly Val His Glu Lys Thr Pro Val Val His Val Lys Ser Arg 
225                 230                 235                 240 


Asp Gly His Leu Leu Pro Tyr Leu Pro His Leu Leu Lys Leu Thr Cys 
                245                 250                 255     


Ser Tyr Glu Gln Leu Pro Pro Leu Met Thr Lys Lys Val Asn Arg Leu 
            260                 265                 270         


Ile Lys Leu Ser Pro His Glu Lys Met Ser Lys Leu Tyr Thr Glu Thr 
        275                 280                 285             


Phe Arg Leu Leu Gly Gln Gln Gln Val Leu Thr Phe Gln Lys Glu Asn 
    290                 295                 300                 


Val Arg Ala Val Asn Leu Gly Tyr Asp Val Asn Glu Leu Asp Ser Pro 
305                 310                 315                 320 


Ile Met Val Phe Gly Gln Gly Tyr Lys Thr Asn Glu Ile Tyr Arg Gly 
                325                 330                 335     


Leu Lys Gln Ser Gly Val Tyr Glu Pro Ser Ser Val Ala Ile Ser Phe 
            340                 345                 350         


Phe Val Asp Pro Glu Leu Asn Tyr Asp Leu Gln Lys Arg Lys Glu Val 
        355                 360                 365             


Gly Tyr Phe Val Lys Lys Leu Glu Ser Met Ser Glu Ala Leu Gly Val 
    370                 375                 380                 


Lys Leu Asn Ile Ser Asp Gln Pro Arg Gln Leu Tyr Gly Gln Leu Pro 
385                 390                 395                 400 


Lys Asp Phe Phe Lys Gln Asp Asn Leu Ser Tyr His Leu Lys Ser Ile 
                405                 410                 415     


Thr Asp Gln Phe Arg Gly Thr Val Val Val Val Ile Gly Thr Glu Glu 
            420                 425                 430         


Asn Ile Asp Arg Ala Tyr Val Thr Ile Lys Lys Glu Phe Gly Gly Lys 
        435                 440                 445             


Glu Asp Leu Met Thr Gln Phe Val Gly Phe Thr Ser Ser Leu Val Thr 
    450                 455                 460                 


Glu Asn Asn Ile Phe His Tyr Tyr Asn Ile Leu Leu Gly Ile Tyr Ala 
465                 470                 475                 480 


Lys Ala Gly Ile Gln Pro Trp Ile Leu Ala Ser Pro Met His Ser Asp 
                485                 490                 495     


Cys Phe Ile Gly Leu Asp Val Ser His Glu His Gly Lys His Ala Ser 
            500                 505                 510         


Gly Ile Ile Gln Val Ile Gly Arg Asp Gly Lys Ile Ile Lys Gln Lys 
        515                 520                 525             


Ser Val Val Thr Ala Glu Ala Gly Glu Thr Ile Ala Asn Ser Thr Met 
    530                 535                 540                 


Glu Glu Ile Val Asn Glu Ser Ile Tyr Gly Tyr Glu Gln Ile Tyr Gly 
545                 550                 555                 560 


Ala Lys Pro Arg His Ile Thr Phe His Arg Asp Gly Val Cys Arg Glu 
                565                 570                 575     


Asp Leu Glu Phe Leu Gln Ala Tyr Leu Arg Ser Phe Gln Ile Pro Phe 
            580                 585                 590         


Gly Phe Val Glu Ile Ile Lys Lys Pro Arg Arg Arg Met Ala Ile Tyr 
        595                 600                 605             


Ser Asn Lys Lys Trp Val Thr Lys Gln Gly Val Tyr Tyr Ser Lys Gly 
    610                 615                 620                 


Asn Thr Ala Tyr Leu Cys Ala Thr Asp Pro Lys Glu Phe Val Gly Met 
625                 630                 635                 640 


Ala Gln Leu Val Lys Ile Val Lys Lys Thr Asn Gly Leu Ser Val His 
                645                 650                 655     


Glu Ile Val Ser Asp Val Tyr Lys Leu Ser Phe Met His Ile His Ser 
            660                 665                 670         


Met Leu Lys Thr Arg Leu Pro Ile Thr Ile His Tyr Ala Asp Leu Ser 
        675                 680                 685             


Ser Thr Phe His Asn Arg Gly Leu Ile His Pro Arg Ser Gln His Glu 
    690                 695                 700                 


Arg Ala Leu Pro Phe Val 
705                 710 


<210>  124
<211>  710
<212>  PRT
<213>  Parageobacillus thermantarcticus


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A1I0T5N6

<400>  124

Met Asn His Tyr Tyr Phe Ser Glu Cys Lys Ala Asp Glu Lys Ala Ser 
1               5                   10                  15      


Asp Ile Ala Ile His Leu Tyr Thr Val Pro Leu Ser Asn Pro His Glu 
            20                  25                  30          


Lys Tyr Ser Tyr Ala His Ser Ile Ala Tyr Glu Leu Arg Lys Leu Asn 
        35                  40                  45              


Ser Tyr Ile Thr Val Ala Ala His Gly Gln Tyr Ile Ala Ser Phe Glu 
    50                  55                  60                  


Glu Ile Cys His Trp Gly Asp Arg Arg Tyr Ile Arg His Glu His Arg 
65                  70                  75                  80  


Pro Ile Gln Cys Ser Leu Pro Met Glu Arg Thr Ile Leu Glu Lys Leu 
                85                  90                  95      


Leu Lys Lys Glu Leu Glu Asn Arg Cys Gln Ser Gly Tyr Lys Met Asp 
            100                 105                 110         


Asn Asp Leu Phe Arg Leu Ala Asn Glu Gln Ser Met His Val Gly Glu 
        115                 120                 125             


Ile Ser Ile His Pro Ala Ile Tyr Ile Ser Phe Ser Val Glu Glu Asn 
    130                 135                 140                 


Gly Asp Ile Phe Val Gly Phe Asp Tyr Gln His Arg Phe Glu Tyr Arg 
145                 150                 155                 160 


Lys Thr Leu Gln Asp Phe Ile Asp Thr Asp Pro Ser Leu Leu Lys Glu 
                165                 170                 175     


Gly Met Glu Val Val Asp Leu Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr 
            180                 185                 190         


Phe Val Glu Ile Ala Asp Tyr Thr Ala Gly Gln Lys Ser Pro Phe Leu 
        195                 200                 205             


Gln Gln Ser Val Ile Asp Tyr Tyr Leu Glu Lys Asn Glu Arg Trp Lys 
    210                 215                 220                 


Leu Lys Gly Val His Glu Lys Thr Pro Ile Val His Val Lys Ser Arg 
225                 230                 235                 240 


Asp Gly His Leu Leu Pro Tyr Leu Pro His Leu Leu Lys Leu Thr Cys 
                245                 250                 255     


Ser Tyr Glu Gln Leu Pro Pro Ser Met Thr Lys Lys Val Asn Arg Leu 
            260                 265                 270         


Ile Lys Leu Ser Pro His Glu Lys Met Ser Lys Leu Tyr Thr Glu Thr 
        275                 280                 285             


Phe His Leu Leu Gly Gln Gln Gln Val Leu Thr Phe Gln Lys Glu Asn 
    290                 295                 300                 


Val Arg Ala Val Asn Leu Gly Tyr Asp Val Asn Glu Leu Asp Ser Pro 
305                 310                 315                 320 


Leu Met Ala Phe Gly Gln Gly Tyr Lys Thr Asn Glu Ile Tyr Arg Gly 
                325                 330                 335     


Leu Lys Gln Ser Gly Val Tyr Glu Pro Ser Ser Val Ala Ile Ser Phe 
            340                 345                 350         


Phe Val Asp Pro Glu Leu Asn Tyr Asp Leu Gln Lys Arg Lys Glu Val 
        355                 360                 365             


Gly Tyr Phe Val Lys Lys Leu Glu Ser Met Ser Glu Ala Leu Gly Val 
    370                 375                 380                 


Lys Leu Asn Ile Ser Asp Gln Pro Arg Gln Leu Tyr Gly Gln Leu Pro 
385                 390                 395                 400 


Lys Asp Phe Phe Lys Gln Asp Asn Leu Ser Tyr His Leu Lys Ser Ile 
                405                 410                 415     


Thr Asp Gln Phe Arg Gly Thr Val Val Val Val Ile Gly Thr Glu Glu 
            420                 425                 430         


Asn Ile Asp Arg Ala Tyr Val Thr Ile Lys Lys Glu Phe Gly Gly Lys 
        435                 440                 445             


Glu Asp Leu Met Thr Gln Phe Val Gly Phe Thr Ser Ser Leu Val Thr 
    450                 455                 460                 


Glu Asn Asn Ile Phe His Tyr Tyr Asn Ile Leu Leu Gly Ile Tyr Ala 
465                 470                 475                 480 


Lys Ala Gly Ile Gln Pro Trp Ile Leu Ser Ser Pro Met His Ser Glu 
                485                 490                 495     


Cys Phe Ile Gly Leu Asp Val Ser His Glu Gln Gly Arg His Ala Ser 
            500                 505                 510         


Gly Ile Val Gln Ile Ile Gly Arg Glu Gly Lys Ile Ile Lys Gln Lys 
        515                 520                 525             


Ser Val Ala Ala Ala Glu Ser Gly Glu Thr Ile Ala Asn Ser Thr Met 
    530                 535                 540                 


Glu Glu Ile Val Asn Glu Ser Ile Tyr Ser Tyr Glu Gln Thr Tyr Gly 
545                 550                 555                 560 


Ala Lys Pro Arg His Ile Thr Phe His Arg Asp Gly Ile Cys Arg Glu 
                565                 570                 575     


Asp Leu Asp Phe Leu Gln Ala Tyr Leu Arg Ser Phe Gln Ile Pro Phe 
            580                 585                 590         


Asp Phe Val Glu Ile Ile Lys Lys Pro Arg Arg Arg Met Ala Ile Tyr 
        595                 600                 605             


Ser Asn Lys Lys Trp Val Thr Lys Gln Gly Val Tyr Tyr Ser Lys Gly 
    610                 615                 620                 


Asn Met Ala Tyr Leu Cys Ala Thr Asp Pro Lys Glu Ala Val Gly Met 
625                 630                 635                 640 


Ala Gln Pro Ile Lys Ile Val Gln Lys Thr Asn Gly Leu Ser Ile His 
                645                 650                 655     


Glu Ile Val Ser Asp Ile Tyr Lys Leu Ser Phe Met His Ile His Ser 
            660                 665                 670         


Met Leu Lys Thr Arg Leu Pro Ile Thr Ile His Tyr Ala Asp Leu Ser 
        675                 680                 685             


Ser Thr Phe His Asn Arg Gly Leu Ile His Pro Arg Ser Gln His Glu 
    690                 695                 700                 


Arg Ala Leu Pro Phe Val 
705                 710 


<210>  125
<211>  87
<212>  PRT
<213>  Geobacillus stearothermophilus


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A150MMB4

<400>  125

Met Glu Val Val Asp Pro Phe Asn Arg Arg Ala Tyr Tyr Tyr Thr Phe 
1               5                   10                  15      


Val Glu Ile Ala Asp Tyr Thr Ala Gly Gln Lys Ser Pro Phe Leu Gln 
            20                  25                  30          


Gln Ser Val Ile Asp Tyr Tyr Leu Glu Lys Asn Glu Arg Trp Lys Leu 
        35                  40                  45              


Lys Ser Val His Glu Lys Thr Pro Val Val His Val Lys Ser Arg Asp 
    50                  55                  60                  


Gly His Leu Leu Pro Tyr Leu Pro His Leu Leu Lys Leu Thr Cys Phe 
65                  70                  75                  80  


Pro Arg Asn Val Arg Val Tyr 
                85          


<210>  126
<211>  744
<212>  PRT
<213>  Fusicatenibacter saccharivorans


<220>
<221>  misc_feature
<223>  UniProt ID No: A0A174UAQ4

<400>  126

Met Glu Lys Asp Leu Lys Met Glu Val Phe Ala Ser Val Asp Thr Val 
1               5                   10                  15      


Lys Pro Val Glu Phe His Val Tyr Glu Leu His Val Gln Lys Ile Gly 
            20                  25                  30          


Asn Thr Tyr Ser Ile Ile Arg Gly Ala Ala Trp Lys Leu Arg Asn Trp 
        35                  40                  45              


Asn Gln Ala Gly Val Phe Glu Asp Gly Asn Lys Ile Tyr Ala Thr Glu 
    50                  55                  60                  


Lys Leu Gln Glu Lys Ile Pro Asn Ala Asp Phe Thr Val Glu Tyr Glu 
65                  70                  75                  80  


Gly Ser Arg Glu Leu Pro Val Leu Glu Asn Arg Arg Ile Tyr Gln Glu 
                85                  90                  95      


Leu Ile Lys Tyr Trp Ile Thr Gln Lys Leu Ser Gln Ile Leu Ile Phe 
            100                 105                 110         


Gly Lys Tyr Arg Lys Tyr Ser Cys Lys Ser Asn Val Thr Ser Lys Trp 
        115                 120                 125             


Ile Met Thr Asn Gln Gly Phe Glu Thr Phe Ser Ser Gly Asn Arg Glu 
    130                 135                 140                 


Ile Ser Leu Glu Arg Lys Tyr Asn Phe Trp Val Thr Ile Met Asp Asp 
145                 150                 155                 160 


Glu Lys Ala Tyr Leu Arg Ile Asp Thr Ser Ser Leu Phe Ser Ser Asn 
                165                 170                 175     


Gln Thr Val Ala Asp Tyr Leu Glu Lys Gly Leu Asn Leu Ile Gly Gln 
            180                 185                 190         


Glu Val Lys Asn Asp Trp Ala Lys Asn Asn Gln Thr Gly Ile Leu Thr 
        195                 200                 205             


Glu Ile Cys Asp Leu Thr Val Thr Asp Lys Leu Asp Phe Ala Asp Ser 
    210                 215                 220                 


Leu Lys Ala Tyr Tyr Ile Gln Arg Asn Glu Ala Tyr Arg Val Glu Asn 
225                 230                 235                 240 


Ile Ser Asp Asp Thr Arg Met Val Lys Val Ala Leu Gln Thr Gly Ile 
                245                 250                 255     


Glu Leu Pro Tyr Tyr Pro Gln Ala Leu Lys Pro Val Leu Thr Arg Glu 
            260                 265                 270         


Thr Val Ser Arg Met Asp Ala Ala Phe Ser Met Arg Thr Glu Ser Leu 
        275                 280                 285             


Val Lys Arg Asn Met Lys Thr Arg Val Leu Leu Asp Gln Asp Phe Ile 
    290                 295                 300                 


Gln Asp Ile Gly Thr Ile Glu Pro Leu Asp Gly Met Lys Phe Glu Thr 
305                 310                 315                 320 


Asp Pro Cys Thr Val Glu Lys Ile Gly Tyr Lys Lys Gly Lys Val Lys 
                325                 330                 335     


Glu Pro Leu Leu Val Cys Gly Lys Asp Lys Ala Leu Lys Cys Gly Glu 
            340                 345                 350         


Glu Phe Lys Val Phe Asn Tyr Gly Phe Tyr Arg Lys Thr Glu Lys Glu 
        355                 360                 365             


Ile Lys Ile Gly Tyr Leu Tyr Pro Arg Asn Ser Tyr Asp Leu Met Lys 
    370                 375                 380                 


Ala Val Val Asn Gly Ile Tyr Thr Phe Ala Lys Leu Gly Lys Tyr His 
385                 390                 395                 400 


Gly Glu Lys Asp Leu Tyr Thr Met Ala Gly Leu Leu Asp Leu Asp Val 
                405                 410                 415     


Lys Ala Met Val Arg Glu Glu Tyr Glu Leu Gly Asp Ile Thr Asp Tyr 
            420                 425                 430         


Lys Arg Ala Ala Asn Lys Leu Gln Lys Ile Glu Gly Ile Asn Leu Val 
        435                 440                 445             


Ile Ala Leu Val Pro Asp Gly Met Glu Glu Asp Gly Pro Tyr Asn Pro 
    450                 455                 460                 


Phe Lys Thr Ile Trp Ala Lys Ala Asn Ile Pro Ser Gln Met Ile Ser 
465                 470                 475                 480 


Met Lys Thr Ala Lys Leu Phe Ala Glu Glu Ala Lys Glu Gly Asn Lys 
                485                 490                 495     


Ala Lys Asn Asn Ser Arg Tyr Tyr Leu His Asn Ile Ile Leu Gly Ile 
            500                 505                 510         


Leu Gly Lys Thr Gly Gly Ile Pro Trp Val Val Lys Asp Met Pro Gly 
        515                 520                 525             


Asn Val Asp Cys Phe Val Gly Leu Asp Val Ala Thr Ile Ala Lys Gly 
    530                 535                 540                 


Ile His Tyr Pro Ala Cys Ser Val Val Phe Asp Lys Tyr Gly Arg Leu 
545                 550                 555                 560 


Leu Gly Phe Tyr Lys Pro Ala Ala Pro Gln Gln Gly Glu Lys Ile Thr 
                565                 570                 575     


Thr Arg Ile Leu Gln Asp Ile Phe Asp Gln Val Ile Phe Ala Tyr Glu 
            580                 585                 590         


Asp Arg Phe Gly Glu Met Pro Lys Asn Ile Val Ile His Arg Asp Gly 
        595                 600                 605             


Phe Ser Asn Glu Asp Asp Glu Trp Tyr Lys Asn Tyr Phe Ala Ala Lys 
    610                 615                 620                 


Gly Ile Met Tyr Asn Ile Ile Glu Val Arg Lys Asn Ile Ser Ser Lys 
625                 630                 635                 640 


Leu Ile Phe Trp Gln Asn Gly Gln Ile Glu Asn Pro Pro Met Gly Tyr 
                645                 650                 655     


Cys Val Tyr Asn Ala Asp Lys Gly Tyr Leu Val Thr Thr Asn Met Lys 
            660                 665                 670         


Asn Lys Lys Gly Ser Pro Asn Pro Ile Leu Ile Glu Lys Lys Cys Gly 
        675                 680                 685             


Asn Leu Ser Met Ala Asp Ile Leu Thr Gln Val Leu Tyr Leu Ser Gln 
    690                 695                 700                 


Leu His Val Gly Ser Thr Gln Lys Met Arg Leu Pro Ile Thr Thr Gly 
705                 710                 715                 720 


Tyr Ala Asp Lys Ile Cys Lys Asn Arg Glu Phe Val Pro Glu Gly Lys 
                725                 730                 735     


Met Asp Asp Arg Leu Phe Phe Leu 
            740                 


<210>  127
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA33

<400>  127
aatctcatag tagggttttg gtt                                               23


<210>  128
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA34

<400>  128
tgagctccat agcttcaaat gtt                                               23


<210>  129
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA35

<400>  129
ccagttacac gctgaaataa at                                                22


<210>  130
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssODN10

<400>  130
atgcctgtga ggagccacca acatttgaag ctatggagct cattggtaaa ccaaaaccct       60

actatgagat tggtgaacga gtagattata agtgtaaaaa aggatacttc tatatacctc      120

ctcttgccac ccatactatt tgtgatcgga atcatacatg gctacctgtc tcagatgacg      180

cctgttata                                                              189


<210>  131
<211>  803
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  expressed AGO A0A1C0UUC4 preparation


<220>
<221>  misc_feature
<222>  (2)..(15)
<223>  V5 tag

<220>
<221>  misc_feature
<222>  (16)..(24)
<223>  c-Myc NLS

<220>
<221>  misc_feature
<222>  (25)..(774)
<223>  A0A1C0UUC4 amino acid sequence minus the first methionine

<220>
<221>  misc_feature
<222>  (775)..(781)
<223>  SV40 NLS 1

<220>
<221>  misc_feature
<222>  (784)..(790)
<223>  SV40 NLS 2

<220>
<221>  misc_feature
<222>  (794)..(801)
<223>  StrepTagII

<400>  131

Met Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Pro 
1               5                   10                  15      


Ala Ala Lys Arg Val Lys Leu Asp Asp Ile Arg Glu Leu Ser Phe Gln 
            20                  25                  30          


Ser Arg Lys Pro Leu Gly Ala Val Pro Ala Arg Arg Asp Arg Leu Arg 
        35                  40                  45              


Ile Val Gly Ser Ala Thr Pro Ile Glu Thr Leu Tyr Ser Leu Ala Arg 
    50                  55                  60                  


Phe Cys Lys Phe Arg Leu Asn Gln Trp Val Thr Asn Asp Gln Ser Ser 
65                  70                  75                  80  


Leu Ala Leu Ile Ser Glu Asp Arg Gly Gln Ala Ala Asn Leu Leu Ala 
                85                  90                  95      


Cys Leu Arg Gln Phe Cys Glu Thr Ser Ser Glu Pro Leu Glu Ile Glu 
            100                 105                 110         


Ile Leu Lys Ser Glu Ala Ile Asp Leu Ser Glu Pro Arg Tyr Gln Asn 
        115                 120                 125             


Trp Leu Phe Gln Leu Cys Asn Tyr Arg Leu Cys Ser Ile Phe Lys Thr 
    130                 135                 140                 


Ile Asn Pro His Ser Ala Lys Lys Val Gln Glu Thr Arg Lys Arg Ile 
145                 150                 155                 160 


Tyr Ser Asn Glu Pro Pro Met Gln Ile Arg Asp Pro Gln Gly Arg Ile 
                165                 170                 175     


Ile Ala Glu Ala Arg Arg Tyr Leu Thr Phe Asp Phe Trp Gln Asn Ser 
            180                 185                 190         


Ala Gly Phe Leu Phe Leu Thr Leu His Phe Arg Asn Glu Tyr Gln Ser 
        195                 200                 205             


Ile Gly Thr Ile Asp Gln Phe Asp Trp Gln Gln Phe Pro Pro Lys Gln 
    210                 215                 220                 


Arg Leu Ile His Thr Tyr Asp Gly Lys Ser Cys Gln Phe Leu Gly Val 
225                 230                 235                 240 


Ala Pro Ile Thr Ile Gly Gln Pro Leu Ala Glu Leu Gly Asn Gln Ser 
                245                 250                 255     


Leu Leu Asn Tyr His Cys Asp Arg Gln Asn Leu Pro Pro Glu Leu Ala 
            260                 265                 270         


Ala Gln Leu Asp Pro Asn Gln Pro Ala Val Ala Val Gly Tyr Pro Pro 
        275                 280                 285             


Arg Tyr Gln Pro Phe His His Leu Pro Gln Leu Leu Lys Arg Ile Tyr 
    290                 295                 300                 


Ala Arg Glu Asp Leu Pro Ser Lys Ser Leu Asn His Cys Ile Leu Pro 
305                 310                 315                 320 


Leu Ala Lys Arg Arg Glu Leu Met Gln Lys Thr Ile Asp Leu Leu Asn 
                325                 330                 335     


Lys Arg Glu Phe Ile Cys Gly Asp Arg Ile Glu Phe Asp Pro Asn Pro 
            340                 345                 350         


Trp Gln Pro Asp Arg Leu Thr Gln Leu Thr Ala Gly Ser Met Ala Arg 
        355                 360                 365             


Asn Leu Ser Phe Gly Ala Asp Pro Gln Gln Pro Asp Arg Pro Ile Leu 
    370                 375                 380                 


Val Asp Glu Ala Trp Arg Gly Trp Lys Gln Arg Thr Leu His Gln Lys 
385                 390                 395                 400 


Pro Ala Glu Ile Arg Thr Gln Val Leu Tyr Pro Gln Ala Trp Glu Ala 
                405                 410                 415     


Glu Val Lys Lys Tyr Met Ser Ala Leu Lys Ser Arg Phe Gln Glu Phe 
            420                 425                 430         


Gly Ile Thr Leu Thr Arg Ala Gly Asp Leu Arg Pro Tyr Asp Pro Gln 
        435                 440                 445             


Asn Ser Leu Ser Leu Arg Gln Val Cys Gln Asn Leu Pro Val Asn Ala 
    450                 455                 460                 


Asn Asp Leu Ile Phe Ala Phe Val Pro Asn Gly Ala Asp Pro Ile Tyr 
465                 470                 475                 480 


Asn Ala Gln Val Asn Pro Tyr Phe Thr Leu Lys Arg Ile Leu Asn Gln 
                485                 490                 495     


Gln Ser Tyr Cys Ser Gln Met Val Thr Arg Glu Thr Met Arg Gln Ile 
            500                 505                 510         


Asn Asn Asp Gly Arg Asp Gln Asn Val Val Phe Gly Ile Leu Ala Lys 
        515                 520                 525             


Leu Gly Tyr Ala Pro Trp Gln Leu His Gln Met Pro Gly Thr Ala Gln 
    530                 535                 540                 


Ala Phe Val Gly Leu Asp Leu Gly Arg Lys Glu Glu Arg Thr Ile Gly 
545                 550                 555                 560 


Ala Ser Ala Phe Val Val Asn Arg Gln Gly Gln Ala Ile Gly Trp Ser 
                565                 570                 575     


Ser Ala Ser Met Gln Arg Gly Glu Thr Phe Ser Glu Thr Ser Leu Arg 
            580                 585                 590         


Asn Ile Leu Leu Asp Leu Phe Gly Ala Phe Thr Glu Gln Ser Gly Glu 
        595                 600                 605             


Pro Leu Arg His Val Val Ile His Arg Asp Gly Thr Val Lys Asn Ser 
    610                 615                 620                 


Glu Leu Ala Thr Leu Gln Ala Leu Glu Ala Glu Leu Arg Pro His Gly 
625                 630                 635                 640 


Leu Glu Gln Leu Glu Val Val Glu Val Val Lys Asp Val Leu Ala Arg 
                645                 650                 655     


Ala Ala Val Arg Ala Ile Asp Pro Asn Thr Asn Gln Glu Gln Trp Gln 
            660                 665                 670         


Asn Pro Asp Arg Gly Trp Ala Trp Val His Asn Asp His Glu Ala Ile 
        675                 680                 685             


Val Leu Thr Thr Gly Ala Lys Gln Ala Lys Val Ala Pro Asn Ala Ser 
    690                 695                 700                 


Pro Gln Pro Leu Leu Val Arg Arg Arg His Gly Gln Thr Asp Ile Leu 
705                 710                 715                 720 


Thr Ile Ala Ala Gln Ile Tyr Trp Leu Ser Glu Met His Ile Gly Ser 
                725                 730                 735     


Thr Gln Val Ile Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp Arg Ile 
            740                 745                 750         


Ala Glu Val Ala Leu Lys Asp Cys Leu Pro Ala Asp Val Arg Cys Glu 
        755                 760                 765             


Arg Arg Leu Tyr Phe Val Pro Lys Lys Lys Arg Lys Val Glu Asp Pro 
    770                 775                 780                 


Lys Lys Lys Arg Lys Val Asp Gly Ser Trp Ser His Pro Gln Phe Glu 
785                 790                 795                 800 


Lys Gly Ser 
            


<210>  132
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_11


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  132
tatgattccg a                                                            11


<210>  133
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_13


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  133
tatgattccg atc                                                          13


<210>  134
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_15


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  134
tatgattccg atcac                                                        15


<210>  135
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_17


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  135
tatgattccg atcacaa                                                      17


<210>  136
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_19


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  136
tatgattccg atcacaaat                                                    19


<210>  137
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_23


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  137
tatgattccg atcacaaata gta                                               23


<210>  138
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_25


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  138
tatgattccg atcacaaata gtatg                                             25


<210>  139
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_27


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  139
tatgattccg atcacaaata gtatggg                                           27


<210>  140
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_29


<220>
<221>  misc_feature
<223>  5'end phosphorylated

<400>  140
tatgattccg atcacaaata gtatgggtg                                         29


<210>  141
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_23_up

<400>  141
tatgattccg atcacaaata gta                                               23


<210>  142
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_23_1mm

<400>  142
tatgattccg agcacaaata gta                                               23


<210>  143
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_23_2mm

<400>  143
tatgattacg agcacaaata gta                                               23


<210>  144
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_23_3mm

<400>  144
tatgattacg agcacagata gta                                               23


<210>  145
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_23_4mm

<400>  145
tattattacg agcacagata gta                                               23


<210>  146
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_23_5mm

<400>  146
tattattact agcacagata gta                                               23


<210>  147
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDNA8_23_6mm

<400>  147
tattattact agcacagata tta                                               23


<210>  148
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D8_17

<400>  148
tatgattccg atcacaa                                                      17


<210>  149
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MM1

<400>  149
atacattccg atcacaa                                                      17


<210>  150
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MM2

<400>  150
tatgtaagcg atcacaa                                                      17


<210>  151
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MM3

<400>  151
tatgattcgc tacacaa                                                      17


<210>  152
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MM4

<400>  152
tatgattccg atgtgta                                                      17


<210>  153
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPIB ssODN1

<400>  153
ccctccccta gcaacgcccc tttaaagaag ctaagttgga aatggtctct ttcctcaggt       60

gtattttgac ctacgaattg gagatgaaga tgtaggccgg gtgatctttg gtctcttcgg      120

aaagactgtt                                                             130


<210>  154
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AG43

<400>  154
atcttcatct ccaattcg                                                     18


<210>  155
<211>  774
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-NLS AGO A0A1C0UUC4


<220>
<221>  misc_feature
<222>  (2)..(15)
<223>  V5 epitope tag

<220>
<221>  misc_feature
<222>  (16)..(24)
<223>  c-Myc NLS

<220>
<221>  misc_feature
<222>  (25)..(774)
<223>  A0A1C0UUC4 amino acid sequence minus the first methionine

<400>  155

Met Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Pro 
1               5                   10                  15      


Ala Ala Lys Arg Val Lys Leu Asp Asp Ile Arg Glu Leu Ser Phe Gln 
            20                  25                  30          


Ser Arg Lys Pro Leu Gly Ala Val Pro Ala Arg Arg Asp Arg Leu Arg 
        35                  40                  45              


Ile Val Gly Ser Ala Thr Pro Ile Glu Thr Leu Tyr Ser Leu Ala Arg 
    50                  55                  60                  


Phe Cys Lys Phe Arg Leu Asn Gln Trp Val Thr Asn Asp Gln Ser Ser 
65                  70                  75                  80  


Leu Ala Leu Ile Ser Glu Asp Arg Gly Gln Ala Ala Asn Leu Leu Ala 
                85                  90                  95      


Cys Leu Arg Gln Phe Cys Glu Thr Ser Ser Glu Pro Leu Glu Ile Glu 
            100                 105                 110         


Ile Leu Lys Ser Glu Ala Ile Asp Leu Ser Glu Pro Arg Tyr Gln Asn 
        115                 120                 125             


Trp Leu Phe Gln Leu Cys Asn Tyr Arg Leu Cys Ser Ile Phe Lys Thr 
    130                 135                 140                 


Ile Asn Pro His Ser Ala Lys Lys Val Gln Glu Thr Arg Lys Arg Ile 
145                 150                 155                 160 


Tyr Ser Asn Glu Pro Pro Met Gln Ile Arg Asp Pro Gln Gly Arg Ile 
                165                 170                 175     


Ile Ala Glu Ala Arg Arg Tyr Leu Thr Phe Asp Phe Trp Gln Asn Ser 
            180                 185                 190         


Ala Gly Phe Leu Phe Leu Thr Leu His Phe Arg Asn Glu Tyr Gln Ser 
        195                 200                 205             


Ile Gly Thr Ile Asp Gln Phe Asp Trp Gln Gln Phe Pro Pro Lys Gln 
    210                 215                 220                 


Arg Leu Ile His Thr Tyr Asp Gly Lys Ser Cys Gln Phe Leu Gly Val 
225                 230                 235                 240 


Ala Pro Ile Thr Ile Gly Gln Pro Leu Ala Glu Leu Gly Asn Gln Ser 
                245                 250                 255     


Leu Leu Asn Tyr His Cys Asp Arg Gln Asn Leu Pro Pro Glu Leu Ala 
            260                 265                 270         


Ala Gln Leu Asp Pro Asn Gln Pro Ala Val Ala Val Gly Tyr Pro Pro 
        275                 280                 285             


Arg Tyr Gln Pro Phe His His Leu Pro Gln Leu Leu Lys Arg Ile Tyr 
    290                 295                 300                 


Ala Arg Glu Asp Leu Pro Ser Lys Ser Leu Asn His Cys Ile Leu Pro 
305                 310                 315                 320 


Leu Ala Lys Arg Arg Glu Leu Met Gln Lys Thr Ile Asp Leu Leu Asn 
                325                 330                 335     


Lys Arg Glu Phe Ile Cys Gly Asp Arg Ile Glu Phe Asp Pro Asn Pro 
            340                 345                 350         


Trp Gln Pro Asp Arg Leu Thr Gln Leu Thr Ala Gly Ser Met Ala Arg 
        355                 360                 365             


Asn Leu Ser Phe Gly Ala Asp Pro Gln Gln Pro Asp Arg Pro Ile Leu 
    370                 375                 380                 


Val Asp Glu Ala Trp Arg Gly Trp Lys Gln Arg Thr Leu His Gln Lys 
385                 390                 395                 400 


Pro Ala Glu Ile Arg Thr Gln Val Leu Tyr Pro Gln Ala Trp Glu Ala 
                405                 410                 415     


Glu Val Lys Lys Tyr Met Ser Ala Leu Lys Ser Arg Phe Gln Glu Phe 
            420                 425                 430         


Gly Ile Thr Leu Thr Arg Ala Gly Asp Leu Arg Pro Tyr Asp Pro Gln 
        435                 440                 445             


Asn Ser Leu Ser Leu Arg Gln Val Cys Gln Asn Leu Pro Val Asn Ala 
    450                 455                 460                 


Asn Asp Leu Ile Phe Ala Phe Val Pro Asn Gly Ala Asp Pro Ile Tyr 
465                 470                 475                 480 


Asn Ala Gln Val Asn Pro Tyr Phe Thr Leu Lys Arg Ile Leu Asn Gln 
                485                 490                 495     


Gln Ser Tyr Cys Ser Gln Met Val Thr Arg Glu Thr Met Arg Gln Ile 
            500                 505                 510         


Asn Asn Asp Gly Arg Asp Gln Asn Val Val Phe Gly Ile Leu Ala Lys 
        515                 520                 525             


Leu Gly Tyr Ala Pro Trp Gln Leu His Gln Met Pro Gly Thr Ala Gln 
    530                 535                 540                 


Ala Phe Val Gly Leu Asp Leu Gly Arg Lys Glu Glu Arg Thr Ile Gly 
545                 550                 555                 560 


Ala Ser Ala Phe Val Val Asn Arg Gln Gly Gln Ala Ile Gly Trp Ser 
                565                 570                 575     


Ser Ala Ser Met Gln Arg Gly Glu Thr Phe Ser Glu Thr Ser Leu Arg 
            580                 585                 590         


Asn Ile Leu Leu Asp Leu Phe Gly Ala Phe Thr Glu Gln Ser Gly Glu 
        595                 600                 605             


Pro Leu Arg His Val Val Ile His Arg Asp Gly Thr Val Lys Asn Ser 
    610                 615                 620                 


Glu Leu Ala Thr Leu Gln Ala Leu Glu Ala Glu Leu Arg Pro His Gly 
625                 630                 635                 640 


Leu Glu Gln Leu Glu Val Val Glu Val Val Lys Asp Val Leu Ala Arg 
                645                 650                 655     


Ala Ala Val Arg Ala Ile Asp Pro Asn Thr Asn Gln Glu Gln Trp Gln 
            660                 665                 670         


Asn Pro Asp Arg Gly Trp Ala Trp Val His Asn Asp His Glu Ala Ile 
        675                 680                 685             


Val Leu Thr Thr Gly Ala Lys Gln Ala Lys Val Ala Pro Asn Ala Ser 
    690                 695                 700                 


Pro Gln Pro Leu Leu Val Arg Arg Arg His Gly Gln Thr Asp Ile Leu 
705                 710                 715                 720 


Thr Ile Ala Ala Gln Ile Tyr Trp Leu Ser Glu Met His Ile Gly Ser 
                725                 730                 735     


Thr Gln Val Ile Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp Arg Ile 
            740                 745                 750         


Ala Glu Val Ala Leu Lys Asp Cys Leu Pro Ala Asp Val Arg Cys Glu 
        755                 760                 765             


Arg Arg Leu Tyr Phe Val 
    770                 


<210>  156
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-NLS AGO A0A1C0UUC4


<220>
<221>  misc_feature
<222>  (2)..(15)
<223>  V5 epitope tag

<220>
<221>  misc_feature
<222>  (16)..(24)
<223>  c-Myc NLS

<220>
<221>  misc_feature
<222>  (25)..(774)
<223>  A0A1C0UUC4 amino acid sequence minus the first methionine

<220>
<221>  misc_feature
<222>  (775)..(782)
<223>  SV40 NLS

<400>  156

Met Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Pro 
1               5                   10                  15      


Ala Ala Lys Arg Val Lys Leu Asp Asp Ile Arg Glu Leu Ser Phe Gln 
            20                  25                  30          


Ser Arg Lys Pro Leu Gly Ala Val Pro Ala Arg Arg Asp Arg Leu Arg 
        35                  40                  45              


Ile Val Gly Ser Ala Thr Pro Ile Glu Thr Leu Tyr Ser Leu Ala Arg 
    50                  55                  60                  


Phe Cys Lys Phe Arg Leu Asn Gln Trp Val Thr Asn Asp Gln Ser Ser 
65                  70                  75                  80  


Leu Ala Leu Ile Ser Glu Asp Arg Gly Gln Ala Ala Asn Leu Leu Ala 
                85                  90                  95      


Cys Leu Arg Gln Phe Cys Glu Thr Ser Ser Glu Pro Leu Glu Ile Glu 
            100                 105                 110         


Ile Leu Lys Ser Glu Ala Ile Asp Leu Ser Glu Pro Arg Tyr Gln Asn 
        115                 120                 125             


Trp Leu Phe Gln Leu Cys Asn Tyr Arg Leu Cys Ser Ile Phe Lys Thr 
    130                 135                 140                 


Ile Asn Pro His Ser Ala Lys Lys Val Gln Glu Thr Arg Lys Arg Ile 
145                 150                 155                 160 


Tyr Ser Asn Glu Pro Pro Met Gln Ile Arg Asp Pro Gln Gly Arg Ile 
                165                 170                 175     


Ile Ala Glu Ala Arg Arg Tyr Leu Thr Phe Asp Phe Trp Gln Asn Ser 
            180                 185                 190         


Ala Gly Phe Leu Phe Leu Thr Leu His Phe Arg Asn Glu Tyr Gln Ser 
        195                 200                 205             


Ile Gly Thr Ile Asp Gln Phe Asp Trp Gln Gln Phe Pro Pro Lys Gln 
    210                 215                 220                 


Arg Leu Ile His Thr Tyr Asp Gly Lys Ser Cys Gln Phe Leu Gly Val 
225                 230                 235                 240 


Ala Pro Ile Thr Ile Gly Gln Pro Leu Ala Glu Leu Gly Asn Gln Ser 
                245                 250                 255     


Leu Leu Asn Tyr His Cys Asp Arg Gln Asn Leu Pro Pro Glu Leu Ala 
            260                 265                 270         


Ala Gln Leu Asp Pro Asn Gln Pro Ala Val Ala Val Gly Tyr Pro Pro 
        275                 280                 285             


Arg Tyr Gln Pro Phe His His Leu Pro Gln Leu Leu Lys Arg Ile Tyr 
    290                 295                 300                 


Ala Arg Glu Asp Leu Pro Ser Lys Ser Leu Asn His Cys Ile Leu Pro 
305                 310                 315                 320 


Leu Ala Lys Arg Arg Glu Leu Met Gln Lys Thr Ile Asp Leu Leu Asn 
                325                 330                 335     


Lys Arg Glu Phe Ile Cys Gly Asp Arg Ile Glu Phe Asp Pro Asn Pro 
            340                 345                 350         


Trp Gln Pro Asp Arg Leu Thr Gln Leu Thr Ala Gly Ser Met Ala Arg 
        355                 360                 365             


Asn Leu Ser Phe Gly Ala Asp Pro Gln Gln Pro Asp Arg Pro Ile Leu 
    370                 375                 380                 


Val Asp Glu Ala Trp Arg Gly Trp Lys Gln Arg Thr Leu His Gln Lys 
385                 390                 395                 400 


Pro Ala Glu Ile Arg Thr Gln Val Leu Tyr Pro Gln Ala Trp Glu Ala 
                405                 410                 415     


Glu Val Lys Lys Tyr Met Ser Ala Leu Lys Ser Arg Phe Gln Glu Phe 
            420                 425                 430         


Gly Ile Thr Leu Thr Arg Ala Gly Asp Leu Arg Pro Tyr Asp Pro Gln 
        435                 440                 445             


Asn Ser Leu Ser Leu Arg Gln Val Cys Gln Asn Leu Pro Val Asn Ala 
    450                 455                 460                 


Asn Asp Leu Ile Phe Ala Phe Val Pro Asn Gly Ala Asp Pro Ile Tyr 
465                 470                 475                 480 


Asn Ala Gln Val Asn Pro Tyr Phe Thr Leu Lys Arg Ile Leu Asn Gln 
                485                 490                 495     


Gln Ser Tyr Cys Ser Gln Met Val Thr Arg Glu Thr Met Arg Gln Ile 
            500                 505                 510         


Asn Asn Asp Gly Arg Asp Gln Asn Val Val Phe Gly Ile Leu Ala Lys 
        515                 520                 525             


Leu Gly Tyr Ala Pro Trp Gln Leu His Gln Met Pro Gly Thr Ala Gln 
    530                 535                 540                 


Ala Phe Val Gly Leu Asp Leu Gly Arg Lys Glu Glu Arg Thr Ile Gly 
545                 550                 555                 560 


Ala Ser Ala Phe Val Val Asn Arg Gln Gly Gln Ala Ile Gly Trp Ser 
                565                 570                 575     


Ser Ala Ser Met Gln Arg Gly Glu Thr Phe Ser Glu Thr Ser Leu Arg 
            580                 585                 590         


Asn Ile Leu Leu Asp Leu Phe Gly Ala Phe Thr Glu Gln Ser Gly Glu 
        595                 600                 605             


Pro Leu Arg His Val Val Ile His Arg Asp Gly Thr Val Lys Asn Ser 
    610                 615                 620                 


Glu Leu Ala Thr Leu Gln Ala Leu Glu Ala Glu Leu Arg Pro His Gly 
625                 630                 635                 640 


Leu Glu Gln Leu Glu Val Val Glu Val Val Lys Asp Val Leu Ala Arg 
                645                 650                 655     


Ala Ala Val Arg Ala Ile Asp Pro Asn Thr Asn Gln Glu Gln Trp Gln 
            660                 665                 670         


Asn Pro Asp Arg Gly Trp Ala Trp Val His Asn Asp His Glu Ala Ile 
        675                 680                 685             


Val Leu Thr Thr Gly Ala Lys Gln Ala Lys Val Ala Pro Asn Ala Ser 
    690                 695                 700                 


Pro Gln Pro Leu Leu Val Arg Arg Arg His Gly Gln Thr Asp Ile Leu 
705                 710                 715                 720 


Thr Ile Ala Ala Gln Ile Tyr Trp Leu Ser Glu Met His Ile Gly Ser 
                725                 730                 735     


Thr Gln Val Ile Arg Leu Pro Ile Thr Thr Tyr Tyr Ala Asp Arg Ile 
            740                 745                 750         


Ala Glu Val Ala Leu Lys Asp Cys Leu Pro Ala Asp Val Arg Cys Glu 
        755                 760                 765             


Arg Arg Leu Tyr Phe Val Pro Lys Lys Lys Arg Lys Val Gly Ser 
    770                 775                 780             


