                         SEQUENCE LISTING

<110>  The University Court of the University of Edinburgh
       The University Court of the University of Glasgow	
 
<120>  MECP2 BASED THERAPY

<130>  P240204WO

<150>  GB 1704704.4
<151>  2017-03-24

<150>  GB 1704722.6
<151>  2017-03-24

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  1

Pro Ala Val Pro Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile 
1               5                   10                  15      


Ile Arg Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly 
            20                  25                  30          


Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys 
        35                  40                  45              


Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys 
    50                  55                  60                  


Val Glu Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp 
65                  70                  75                  80  


Pro Asn Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg 
                85                  90                  95      


Arg Glu Gln Lys Pro Pro 
            100         


<210>  2
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala 
1               5                   10                  15      


Val Lys Glu Ser Ser Ile Arg Ser Val Gln Glu Thr Val Leu Pro Ile 
            20                  25                  30          


Lys Lys Arg Lys Thr Arg Glu Thr Val 
        35                  40      


<210>  3
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Ala Ala Ala Ala Ala Pro Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Glu Glu Glu Arg Leu Glu Glu Lys Ser Glu Asp Gln Asp Leu Gln Gly 
            20                  25                  30          


Leu Lys Asp Lys Pro Leu Lys Phe Lys Lys Val Lys Lys Asp Lys Lys 
        35                  40                  45              


Glu Glu Lys Glu Gly Lys His Glu Pro Val Gln Pro Ser Ala His His 
    50                  55                  60                  


Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu Thr Ser Glu Gly Ser 
65                  70                  75                  80  


Gly Ser Ala Pro Ala Val Pro Glu Ala Ser Ala Ser Pro Lys Gln Arg 
                85                  90                  95      


Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu 
            100                 105                 110         


Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser 
        115                 120                 125             


Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe 
    130                 135                 140                 


Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr 
145                 150                 155                 160 


Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser 
                165                 170                 175     


Pro Ser Arg Arg Glu Gln Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys 
            180                 185                 190         


Ala Pro Gly Thr Gly Arg Gly Arg Gly Arg Pro Lys Gly Ser Gly Thr 
        195                 200                 205             


Thr Arg Pro Lys Ala Ala Thr Ser Glu Gly Val Gln Val Lys Arg Val 
    210                 215                 220                 


Leu Glu Lys Ser Pro Gly Lys Leu Leu Val Lys Met Pro Phe Gln Thr 
225                 230                 235                 240 


Ser Pro Gly Gly Lys Ala Glu Gly Gly Gly Ala Thr Thr Ser Thr Gln 
                245                 250                 255     


Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg Lys Ala Glu Ala Asp 
            260                 265                 270         


Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys Pro Gly Ser Val Val 
        275                 280                 285             


Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala Val Lys Glu Ser Ser 
    290                 295                 300                 


Ile Arg Ser Val Gln Glu Thr Val Leu Pro Ile Lys Lys Arg Lys Thr 
305                 310                 315                 320 


Arg Glu Thr Val Ser Ile Glu Val Lys Glu Val Val Lys Pro Leu Leu 
                325                 330                 335     


Val Ser Thr Leu Gly Glu Lys Ser Gly Lys Gly Leu Lys Thr Cys Lys 
            340                 345                 350         


Ser Pro Gly Arg Lys Ser Lys Glu Ser Ser Pro Lys Gly Arg Ser Ser 
        355                 360                 365             


Ser Ala Ser Ser Pro Pro Lys Lys Glu His His His His His His His 
    370                 375                 380                 


Ser Glu Ser Pro Lys Ala Pro Val Pro Leu Leu Pro Pro Leu Pro Pro 
385                 390                 395                 400 


Pro Pro Pro Glu Pro Glu Ser Ser Glu Asp Pro Thr Ser Pro Pro Glu 
                405                 410                 415     


Pro Gln Asp Leu Ser Ser Ser Val Cys Lys Glu Glu Lys Met Pro Arg 
            420                 425                 430         


Gly Gly Ser Leu Glu Ser Asp Gly Cys Pro Lys Glu Pro Ala Lys Thr 
        435                 440                 445             


Gln Pro Ala Val Ala Thr Ala Ala Thr Ala Ala Glu Lys Tyr Lys His 
    450                 455                 460                 


Arg Gly Glu Gly Glu Arg Lys Asp Ile Val Ser Ser Ser Met Pro Arg 
465                 470                 475                 480 


Pro Asn Arg Glu Glu Pro Val Asp Ser Arg Thr Pro Val Thr Glu Arg 
                485                 490                 495     


Val Ser 
        


<210>  4
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys Ser Glu Asp Gln 
1               5                   10                  15      


Asp Leu Gln Gly Leu Lys Asp Lys Pro Leu Lys Phe Lys Lys Val Lys 
            20                  25                  30          


Lys Asp Lys Lys Glu Glu Lys Glu Gly Lys His Glu Pro Val Gln Pro 
        35                  40                  45              


Ser Ala His His Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu Thr 
    50                  55                  60                  


Ser Glu Gly Ser Gly Ser Ala Pro Ala Val Pro Glu Ala Ser Ala Ser 
65                  70                  75                  80  


Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr Asp 
                85                  90                  95      


Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys 
            100                 105                 110         


Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln 
        115                 120                 125             


Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu Lys 
    130                 135                 140                 


Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val Thr 
145                 150                 155                 160 


Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys Pro Pro Lys Lys Pro 
                165                 170                 175     


Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly Arg Gly Arg Pro Lys 
            180                 185                 190         


Gly Ser Gly Thr Thr Arg Pro Lys Ala Ala Thr Ser Glu Gly Val Gln 
        195                 200                 205             


Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys Leu Leu Val Lys Met 
    210                 215                 220                 


Pro Phe Gln Thr Ser Pro Gly Gly Lys Ala Glu Gly Gly Gly Ala Thr 
225                 230                 235                 240 


Thr Ser Thr Gln Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg Lys 
                245                 250                 255     


Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys Pro 
            260                 265                 270         


Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala Val 
        275                 280                 285             


Lys Glu Ser Ser Ile Arg Ser Val Gln Glu Thr Val Leu Pro Ile Lys 
    290                 295                 300                 


Lys Arg Lys Thr Arg Glu Thr Val Ser Ile Glu Val Lys Glu Val Val 
305                 310                 315                 320 


Lys Pro Leu Leu Val Ser Thr Leu Gly Glu Lys Ser Gly Lys Gly Leu 
                325                 330                 335     


Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser Lys Glu Ser Ser Pro Lys 
            340                 345                 350         


Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro Lys Lys Glu His His His 
        355                 360                 365             


His His His His Ser Glu Ser Pro Lys Ala Pro Val Pro Leu Leu Pro 
    370                 375                 380                 


Pro Leu Pro Pro Pro Pro Pro Glu Pro Glu Ser Ser Glu Asp Pro Thr 
385                 390                 395                 400 


Ser Pro Pro Glu Pro Gln Asp Leu Ser Ser Ser Val Cys Lys Glu Glu 
                405                 410                 415     


Lys Met Pro Arg Gly Gly Ser Leu Glu Ser Asp Gly Cys Pro Lys Glu 
            420                 425                 430         


Pro Ala Lys Thr Gln Pro Ala Val Ala Thr Ala Ala Thr Ala Ala Glu 
        435                 440                 445             


Lys Tyr Lys His Arg Gly Glu Gly Glu Arg Lys Asp Ile Val Ser Ser 
    450                 455                 460                 


Ser Met Pro Arg Pro Asn Arg Glu Glu Pro Val Asp Ser Arg Thr Pro 
465                 470                 475                 480 


Val Thr Glu Arg Val Ser 
                485     


<210>  5
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Ala Ala Ala Ala Ala Pro Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Glu Glu Glu Arg Leu Glu Glu Lys Ser Glu Asp Gln Asp Leu Gln Gly 
            20                  25                  30          


Leu Lys Asp Lys Pro Leu Lys Phe Lys Lys Val Lys Lys Asp Lys Lys 
        35                  40                  45              


Glu Glu Lys Glu Gly Lys His Glu Pro Val Gln Pro Ser Ala His His 
    50                  55                  60                  


Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu Thr Ser Glu Gly Ser 
65                  70                  75                  80  


Gly Ser Ala 
            


<210>  6
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys Ser Glu Asp Gln 
1               5                   10                  15      


Asp Leu Gln Gly Leu Lys Asp Lys Pro Leu Lys Phe Lys Lys Val Lys 
            20                  25                  30          


Lys Asp Lys Lys Glu Glu Lys Glu Gly Lys His Glu Pro Val Gln Pro 
        35                  40                  45              


Ser Ala His His Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu Thr 
    50                  55                  60                  


Ser Glu Gly Ser Gly Ser Ala 
65                  70      


<210>  7
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Lys Pro Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly Arg Gly 
1               5                   10                  15      


Arg Pro Lys Gly Ser Gly Thr Thr Arg Pro Lys Ala Ala Thr Ser Glu 
            20                  25                  30          


Gly Val Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys Leu Leu 
        35                  40                  45              


Val Lys Met Pro Phe Gln Thr Ser Pro Gly Gly Lys Ala Glu Gly Gly 
    50                  55                  60                  


Gly Ala Thr Thr Ser Thr Gln Val Met Val Ile Lys Arg Pro Gly Arg 
65                  70                  75                  80  


Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly 
                85                  90                  95      


Arg Lys 
        


<210>  8
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Ile Glu Val Lys Glu Val Val Lys Pro Leu Leu Val Ser Thr Leu 
1               5                   10                  15      


Gly Glu Lys Ser Gly Lys Gly Leu Lys Thr Cys Lys Ser Pro Gly Arg 
            20                  25                  30          


Lys Ser Lys Glu Ser Ser Pro Lys Gly Arg Ser Ser Ser Ala Ser Ser 
        35                  40                  45              


Pro Pro Lys Lys Glu His His His His His His His Ser Glu Ser Pro 
    50                  55                  60                  


Lys Ala Pro Val Pro Leu Leu Pro Pro Leu Pro Pro Pro Pro Pro Glu 
65                  70                  75                  80  


Pro Glu Ser Ser Glu Asp Pro Thr Ser Pro Pro Glu Pro Gln Asp Leu 
                85                  90                  95      


Ser Ser Ser Val Cys Lys Glu Glu Lys Met Pro Arg Gly Gly Ser Leu 
            100                 105                 110         


Glu Ser Asp Gly Cys Pro Lys Glu Pro Ala Lys Thr Gln Pro Ala Val 
        115                 120                 125             


Ala Thr Ala Ala Thr Ala Ala Glu Lys Tyr Lys His Arg Gly Glu Gly 
    130                 135                 140                 


Glu Arg Lys Asp Ile Val Ser Ser Ser Met Pro Arg Pro Asn Arg Glu 
145                 150                 155                 160 


Glu Pro Val Asp Ser Arg Thr Pro Val Thr Glu Arg Val Ser 
                165                 170                 


<210>  9
<211>  29
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ala Ala Ala Ala Ala Thr Ala Ala Ala Ala Ala Ala Pro Ser Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Glu Glu Glu Arg Leu Glu Glu Lys 
            20                  25                  


<210>  10
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  10

Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys 
1               5                   10          


<210>  11
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ala Ala Ala Ala Ala Ala Pro Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Glu Glu Glu Arg Leu Glu Glu Lys 
            20                  


<210>  12
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys 
1               5                   10          


<210>  13
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dNC: A truncated synthetic polypeptide sequence (from human 
       MeCP2)

<400>  13

Pro Ala Val Pro Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile 
1               5                   10                  15      


Ile Arg Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly 
            20                  25                  30          


Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys 
        35                  40                  45              


Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys 
    50                  55                  60                  


Val Glu Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp 
65                  70                  75                  80  


Pro Asn Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg 
                85                  90                  95      


Arg Glu Gln Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala Pro Gly 
            100                 105                 110         


Thr Gly Arg Gly Arg Gly Arg Pro Lys Gly Ser Gly Thr Thr Arg Pro 
        115                 120                 125             


Lys Ala Ala Thr Ser Glu Gly Val Gln Val Lys Arg Val Leu Glu Lys 
    130                 135                 140                 


Ser Pro Gly Lys Leu Leu Val Lys Met Pro Phe Gln Thr Ser Pro Gly 
145                 150                 155                 160 


Gly Lys Ala Glu Gly Gly Gly Ala Thr Thr Ser Thr Gln Val Met Val 
                165                 170                 175     


Ile Lys Arg Pro Gly Arg Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala 
            180                 185                 190         


Ile Pro Lys Lys Arg Gly Arg Lys Pro Gly Ser Val Val Ala Ala Ala 
        195                 200                 205             


Ala Ala Glu Ala Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser 
    210                 215                 220                 


Val Gln Glu Thr Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr 
225                 230                 235                 240 


Val 
    


<210>  14
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dNIC: A truncated synthetic polypeptide sequence (from human 
       MeCP2)

<400>  14

Pro Ala Val Pro Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile 
1               5                   10                  15      


Ile Arg Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly 
            20                  25                  30          


Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys 
        35                  40                  45              


Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys 
    50                  55                  60                  


Val Glu Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp 
65                  70                  75                  80  


Pro Asn Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg 
                85                  90                  95      


Arg Glu Gln Lys Pro Pro Gly Ser Ser Gly Ser Ser Gly Pro Lys Lys 
            100                 105                 110         


Lys Arg Lys Val Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala 
        115                 120                 125             


Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser Val Gln Glu Thr 
    130                 135                 140                 


Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr Val 
145                 150                 155         


<210>  15
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dN mouse: A truncated synthetic polypeptide sequence (from mouse 
       MeCP2)

<400>  15

Pro Ala Val Pro Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile 
1               5                   10                  15      


Ile Arg Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly 
            20                  25                  30          


Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys 
        35                  40                  45              


Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys 
    50                  55                  60                  


Val Glu Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp 
65                  70                  75                  80  


Pro Asn Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg 
                85                  90                  95      


Arg Glu Gln Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala Pro Gly 
            100                 105                 110         


Thr Gly Arg Gly Arg Gly Arg Pro Lys Gly Ser Gly Thr Gly Arg Pro 
        115                 120                 125             


Lys Ala Ala Ala Ser Glu Gly Val Gln Val Lys Arg Val Leu Glu Lys 
    130                 135                 140                 


Ser Pro Gly Lys Leu Val Val Lys Met Pro Phe Gln Ala Ser Pro Gly 
145                 150                 155                 160 


Gly Lys Gly Glu Gly Gly Gly Ala Thr Thr Ser Ala Gln Val Met Val 
                165                 170                 175     


Ile Lys Arg Pro Gly Arg Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala 
            180                 185                 190         


Ile Pro Lys Lys Arg Gly Arg Lys Pro Gly Ser Val Val Ala Ala Ala 
        195                 200                 205             


Ala Ala Glu Ala Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser 
    210                 215                 220                 


Val His Glu Thr Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr 
225                 230                 235                 240 


Val Ser Ile Glu Val Lys Glu Val Val Lys Pro Leu Leu Val Ser Thr 
                245                 250                 255     


Leu Gly Glu Lys Ser Gly Lys Gly Leu Lys Thr Cys Lys Ser Pro Gly 
            260                 265                 270         


Arg Lys Ser Lys Glu Ser Ser Pro Lys Gly Arg Ser Ser Ser Ala Ser 
        275                 280                 285             


Ser Pro Pro Lys Lys Glu His His His His His His His Ser Glu Ser 
    290                 295                 300                 


Thr Lys Ala Pro Met Pro Leu Leu Pro Ser Pro Pro Pro Pro Glu Pro 
305                 310                 315                 320 


Glu Ser Ser Glu Asp Pro Ile Ser Pro Pro Glu Pro Gln Asp Leu Ser 
                325                 330                 335     


Ser Ser Ile Cys Lys Glu Glu Lys Met Pro Arg Gly Gly Ser Leu Glu 
            340                 345                 350         


Ser Asp Gly Cys Pro Lys Glu Pro Ala Lys Thr Gln Pro Met Val Ala 
        355                 360                 365             


Thr Thr Thr Thr Val Ala Glu Lys Tyr Lys His Arg Gly Glu Gly Glu 
    370                 375                 380                 


Arg Lys Asp Ile Val Ser Ser Ser Met Pro Arg Pro Asn Arg Glu Glu 
385                 390                 395                 400 


Pro Val Asp Ser Arg Thr Pro Val Thr Glu Arg Val Ser 
                405                 410             


<210>  16
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dNC mouse: A truncated synthetic polypeptide sequence (from mouse
       MeCP2)

<400>  16

Pro Ala Val Pro Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile 
1               5                   10                  15      


Ile Arg Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly 
            20                  25                  30          


Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys 
        35                  40                  45              


Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys 
    50                  55                  60                  


Val Glu Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp 
65                  70                  75                  80  


Pro Asn Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg 
                85                  90                  95      


Arg Glu Gln Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala Pro Gly 
            100                 105                 110         


Thr Gly Arg Gly Arg Gly Arg Pro Lys Gly Ser Gly Thr Gly Arg Pro 
        115                 120                 125             


Lys Ala Ala Ala Ser Glu Gly Val Gln Val Lys Arg Val Leu Glu Lys 
    130                 135                 140                 


Ser Pro Gly Lys Leu Val Val Lys Met Pro Phe Gln Ala Ser Pro Gly 
145                 150                 155                 160 


Gly Lys Gly Glu Gly Gly Gly Ala Thr Thr Ser Ala Gln Val Met Val 
                165                 170                 175     


Ile Lys Arg Pro Gly Arg Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala 
            180                 185                 190         


Ile Pro Lys Lys Arg Gly Arg Lys Pro Gly Ser Val Val Ala Ala Ala 
        195                 200                 205             


Ala Ala Glu Ala Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser 
    210                 215                 220                 


Val His Glu Thr Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr 
225                 230                 235                 240 


Val 
    


<210>  17
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dNIC mouse: A truncated synthetic polypeptide sequence (from 
       mouse MeCP2)

<400>  17

Pro Ala Val Pro Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile 
1               5                   10                  15      


Ile Arg Asp Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly 
            20                  25                  30          


Trp Thr Arg Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys 
        35                  40                  45              


Tyr Asp Val Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys 
    50                  55                  60                  


Val Glu Leu Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp 
65                  70                  75                  80  


Pro Asn Asp Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg 
                85                  90                  95      


Arg Glu Gln Lys Pro Pro Gly Ser Ser Gly Ser Ser Gly Pro Lys Lys 
            100                 105                 110         


Lys Arg Lys Val Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala 
        115                 120                 125             


Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser Val His Glu Thr 
    130                 135                 140                 


Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr Val 
145                 150                 155         


<210>  18
<211>  1494
<212>  DNA
<213>  Homo sapiens

<400>  18
atggccgccg ccgccgccgc cgcgccgagc ggaggaggag gaggaggcga ggaggagaga       60

ctggaagaaa agtcagaaga ccaggacctc cagggcctca aggacaaacc cctcaagttt      120

aaaaaggtga agaaagataa gaaagaagag aaagagggca agcatgagcc cgtgcagcca      180

tcagcccacc actctgctga gcccgcagag gcaggcaaag cagagacatc agaagggtca      240

ggctccgccc cggctgtgcc ggaagcttct gcctccccca aacagcggcg ctccatcatc      300

cgtgaccggg gacccatgta tgatgacccc accctgcctg aaggctggac acggaagctt      360

aagcaaagga aatctggccg ctctgctggg aagtatgatg tgtatttgat caatccccag      420

ggaaaagcct ttcgctctaa agtggagttg attgcgtact tcgaaaaggt aggcgacaca      480

tccctggacc ctaatgattt tgacttcacg gtaactggga gagggagccc ctcccggcga      540

gagcagaaac cacctaagaa gcccaaatct cccaaagctc caggaactgg cagaggccgg      600

ggacgcccca aagggagcgg caccacgaga cccaaggcgg ccacgtcaga gggtgtgcag      660

gtgaaaaggg tcctggagaa aagtcctggg aagctccttg tcaagatgcc ttttcaaact      720

tcgccagggg gcaaggctga ggggggtggg gccaccacat ccacccaggt catggtgatc      780

aaacgccccg gcaggaagcg aaaagctgag gccgaccctc aggccattcc caagaaacgg      840

ggccgaaagc cggggagtgt ggtggcagcc gctgccgccg aggccaaaaa gaaagccgtg      900

aaggagtctt ctatccgatc tgtgcaggag accgtactcc ccatcaagaa gcgcaagacc      960

cgggagacgg tcagcatcga ggtcaaggaa gtggtgaagc ccctgctggt gtccaccctc     1020

ggtgagaaga gcgggaaagg actgaagacc tgtaagagcc ctgggcggaa aagcaaggag     1080

agcagcccca aggggcgcag cagcagcgcc tcctcacccc ccaagaagga gcaccaccac     1140

catcaccacc actcagagtc cccaaaggcc cccgtgccac tgctcccacc cctgccccca     1200

cctccacctg agcccgagag ctccgaggac cccaccagcc cccctgagcc ccaggacttg     1260

agcagcagcg tctgcaaaga ggagaagatg cccagaggag gctcactgga gagcgacggc     1320

tgccccaagg agccagctaa gactcagccc gcggttgcca ccgccgccac ggccgcagaa     1380

aagtacaaac accgagggga gggagagcgc aaagacattg tttcatcctc catgccaagg     1440

ccaaacagag aggagcctgt ggacagccgg acgcccgtga ccgagagagt tagc           1494


<210>  19
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dNC: cDNA sequence of a truncated synthetic polypeptide sequence (from 
       human MeCP2)

<400>  19
ccggctgtgc cggaagcttc tgcctccccc aaacagcggc gctccatcat ccgtgaccgg       60

ggacccatgt atgatgaccc caccctgcct gaaggctgga cacggaagct taagcaaagg      120

aaatctggcc gctctgctgg gaagtatgat gtgtatttga tcaatcccca gggaaaagcc      180

tttcgctcta aagtggagtt gattgcgtac ttcgaaaagg taggcgacac atccctggac      240

cctaatgatt ttgacttcac ggtaactggg agagggagcc cctcccggcg agagcagaaa      300

ccacctaaga agcccaaatc tcccaaagct ccaggaactg gcagaggccg gggacgcccc      360

aaagggagcg gcaccacgag acccaaggcg gccacgtcag agggtgtgca ggtgaaaagg      420

gtcctggaga aaagtcctgg gaagctcctt gtcaagatgc cttttcaaac ttcgccaggg      480

ggcaaggctg aggggggtgg ggccaccaca tccacccagg tcatggtgat caaacgcccc      540

ggcaggaagc gaaaagctga ggccgaccct caggccattc ccaagaaacg gggccgaaag      600

ccggggagtg tggtggcagc cgctgccgcc gaggccaaaa agaaagccgt gaaggagtct      660

tctatccgat ctgtgcagga gaccgtactc cccatcaaga agcgcaagac ccgggagacg      720

gtc                                                                    723


<210>  20
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dNIC: cDNA sequence of a truncated synthetic polypeptide sequence (from 
       human MeCP2)

<400>  20
ccggctgtgc cggaagcttc tgcctccccc aaacagcggc gctccatcat ccgtgaccgg       60

ggacccatgt atgatgaccc caccctgcct gaaggctgga cacggaagct taagcaaagg      120

aaatctggcc gctctgctgg gaagtatgat gtgtatttga tcaatcccca gggaaaagcc      180

tttcgctcta aagtggagtt gattgcgtac ttcgaaaagg taggcgacac atccctggac      240

cctaatgatt ttgacttcac ggtaactggg agagggagcc cctcccggcg agagcagaaa      300

ccacctggat ccagtggcag ctctgggccc aagaaaaagc ggaaggtgcc ggggagtgtg      360

gtggcagccg ctgccgccga ggccaaaaag aaagccgtga aggagtcttc tatccgatct      420

gtgcaggaga ccgtactccc catcaagaag cgcaagaccc gggagacggt c               471


<210>  21
<211>  1506
<212>  DNA
<213>  Mus musculus

<400>  21
atggccgccg ctgccgccac cgccgccgcc gccgccgcgc cgagcggagg aggaggagga       60

ggcgaggagg agagactgga ggaaaagtca gaagaccagg atctccaggg cctcagagac      120

aagccactga agtttaagaa ggcgaagaaa gacaagaagg aggacaaaga aggcaagcat      180

gagccactac aaccttcagc ccaccattct gcagagccag cagaggcagg caaagcagaa      240

acatcagaaa gctcaggctc tgccccagca gtgccagaag cctcggcttc ccccaaacag      300

cggcgctcca ttatccgtga ccggggacct atgtatgatg accccacctt gcctgaaggt      360

tggacacgaa agcttaaaca aaggaagtct ggccgatctg ctggaaagta tgatgtatat      420

ttgatcaatc cccagggaaa agcttttcgc tctaaagtag aattgattgc atactttgaa      480

aaggtgggag acacctcctt ggaccctaat gattttgact tcacggtaac tgggagaggg      540

agcccctcca ggagagagca gaaaccacct aagaagccca aatctcccaa agctccagga      600

actggcaggg gtcggggacg ccccaaaggg agcggcactg ggagaccaaa ggcagcagca      660

tcagaaggtg ttcaggtgaa aagggtcctg gagaagagcc ctgggaaact tgttgtcaag      720

atgcctttcc aagcatcgcc tgggggtaag ggtgagggag gtggggctac cacatctgcc      780

caggtcatgg tgatcaaacg ccctggcaga aagcgaaaag ctgaagctga cccccaggcc      840

attcctaaga aacggggtag aaagcctggg agtgtggtgg cagctgctgc agctgaggcc      900

aaaaagaaag ccgtgaagga gtcttccata cggtctgtgc atgagactgt gctccccatc      960

aagaagcgca agacccggga gacggtcagc atcgaggtca aggaagtggt gaagcccctg     1020

ctggtgtcca cccttggtga gaaaagcggg aagggactga agacctgcaa gagccctggg     1080

cgtaaaagca aggagagcag ccccaagggg cgcagcagca gtgcctcctc cccacctaag     1140

aaggagcacc atcatcacca ccatcactca gagtccacaa aggcccccat gccactgctc     1200

ccatccccac ccccacctga gcctgagagc tctgaggacc ccatcagccc ccctgagcct     1260

caggacttga gcagcagcat ctgcaaagaa gagaagatgc cccgaggagg ctcactggaa     1320

agcgatggct gccccaagga gccagctaag actcagccta tggtcgccac cactaccaca     1380

gttgcagaaa agtacaaaca ccgaggggag ggagagcgca aagacattgt ttcatcttcc     1440

atgccaaggc caaacagaga ggagcctgtg gacagccgga cgcccgtgac cgagagagtt     1500

agctct                                                                1506


<210>  22
<211>  1242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dN mouse: cDNA for a truncated synthetic polypeptide sequence 
       (from mouse MeCP2)

<400>  22
ccagcagtgc cagaagcctc ggcttccccc aaacagcggc gctccattat ccgtgaccgg       60

ggacctatgt atgatgaccc caccttgcct gaaggttgga cacgaaagct taaacaaagg      120

aagtctggcc gatctgctgg aaagtatgat gtatatttga tcaatcccca gggaaaagct      180

tttcgctcta aagtagaatt gattgcatac tttgaaaagg tgggagacac ctccttggac      240

cctaatgatt ttgacttcac ggtaactggg agagggagcc cctccaggag agagcagaaa      300

ccacctaaga agcccaaatc tcccaaagct ccaggaactg gcaggggtcg gggacgcccc      360

aaagggagcg gcactgggag accaaaggca gcagcatcag aaggtgttca ggtgaaaagg      420

gtcctggaga agagccctgg gaaacttgtt gtcaagatgc ctttccaagc atcgcctggg      480

ggtaagggtg agggaggtgg ggctaccaca tctgcccagg tcatggtgat caaacgccct      540

ggcagaaagc gaaaagctga agctgacccc caggccattc ctaagaaacg gggtagaaag      600

cctgggagtg tggtggcagc tgctgcagct gaggccaaaa agaaagccgt gaaggagtct      660

tccatacggt ctgtgcatga gactgtgctc cccatcaaga agcgcaagac ccgggagacg      720

gtcagcatcg aggtcaagga agtggtgaag cccctgctgg tgtccaccct tggtgagaaa      780

agcgggaagg gactgaagac ctgcaagagc cctgggcgta aaagcaagga gagcagcccc      840

aaggggcgca gcagcagtgc ctcctcccca cctaagaagg agcaccatca tcaccaccat      900

cactcagagt ccacaaaggc ccccatgcca ctgctcccat ccccaccccc acctgagcct      960

gagagctctg aggaccccat cagcccccct gagcctcagg acttgagcag cagcatctgc     1020

aaagaagaga agatgccccg aggaggctca ctggaaagcg atggctgccc caaggagcca     1080

gctaagactc agcctatggt cgccaccact accacagttg cagaaaagta caaacaccga     1140

ggggagggag agcgcaaaga cattgtttca tcttccatgc caaggccaaa cagagaggag     1200

cctgtggaca gccggacgcc cgtgaccgag agagttagct gt                        1242


<210>  23
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dNC mouse: cDNA for a truncated synthetic polypeptide sequence (from mouse 
       MeCP2)

<400>  23
ccagcagtgc cagaagcctc ggcttccccc aaacagcggc gctccattat ccgtgaccgg       60

ggacctatgt atgatgaccc caccttgcct gaaggttgga cacgaaagct taaacaaagg      120

aagtctggcc gatctgctgg aaagtatgat gtatatttga tcaatcccca gggaaaagct      180

tttcgctcta aagtagaatt gattgcatac tttgaaaagg tgggagacac ctccttggac      240

cctaatgatt ttgacttcac ggtaactggg agagggagcc cctccaggag agagcagaaa      300

ccacctaaga agcccaaatc tcccaaagct ccaggaactg gcaggggtcg gggacgcccc      360

aaagggagcg gcactgggag accaaaggca gcagcatcag aaggtgttca ggtgaaaagg      420

gtcctggaga agagccctgg gaaacttgtt gtcaagatgc ctttccaagc atcgcctggg      480

ggtaagggtg agggaggtgg ggctaccaca tctgcccagg tcatggtgat caaacgccct      540

ggcagaaagc gaaaagctga agctgacccc caggccattc ctaagaaacg gggtagaaag      600

cctgggagtg tggtggcagc tgctgcagct gaggccaaaa agaaagccgt gaaggagtct      660

tccatacggt ctgtgcatga gactgtgctc cccatcaaga agcgcaagac ccgggagacg      720

gtc                                                                    723


<210>  24
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dNIC mouse: cDNA for a truncated synthetic polypeptide sequence 
       (from mouse MeCP2)

<400>  24
ccagcagtgc cagaagcctc ggcttccccc aaacagcggc gctccattat ccgtgaccgg       60

ggacctatgt atgatgaccc caccttgcct gaaggttgga cacgaaagct taaacaaagg      120

aagtctggcc gatctgctgg aaagtatgat gtatatttga tcaatcccca gggaaaagct      180

tttcgctcta aagtagaatt gattgcatac tttgaaaagg tgggagacac ctccttggac      240

cctaatgatt ttgacttcac ggtaactggg agagggagcc cctccaggag agagcagaaa      300

ccacctggat ccagtggcag ctctgggccc aagaaaaagc ggaaggtgcc tgggagtgtg      360

gtggcagctg ctgcagctga ggccaaaaag aaagccgtga aggagtcttc catacggtct      420

gtgcatgaga ctgtgctccc catcaagaag cgcaagaccc gggagacggt c               471


<210>  25
<211>  87
<212>  DNA
<213>  Mus musculus

<400>  25
atggccgccg ctgccgccac cgccgccgcc gccgccgcgc cgagcggagg aggaggagga       60

ggcgaggagg agagactgga ggaaaag                                           87


<210>  26
<211>  46
<212>  DNA
<213>  Mus musculus

<400>  26
atggtagctg ggatgttagg gctcagggag gaaaagggag gaaaag                      46


<210>  27
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  27
atggccgccg ccgccgccgc cgcgccgagc ggaggaggag gaggaggcga ggaggagaga       60

ctggaagaaa ag                                                           72


<210>  28
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  28
atggtagctg ggatgttagg gctcagggaa gaaaag                                 36


<210>  29
<211>  501
<212>  PRT
<213>  Mus musculus

<400>  29

Met Ala Ala Ala Ala Ala Thr Ala Ala Ala Ala Ala Ala Pro Ser Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Glu Glu Glu Arg Leu Glu Glu Lys Ser Glu Asp 
            20                  25                  30          


Gln Asp Leu Gln Gly Leu Arg Asp Lys Pro Leu Lys Phe Lys Lys Ala 
        35                  40                  45              


Lys Lys Asp Lys Lys Glu Asp Lys Glu Gly Lys His Glu Pro Leu Gln 
    50                  55                  60                  


Pro Ser Ala His His Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu 
65                  70                  75                  80  


Thr Ser Glu Ser Ser Gly Ser Ala Pro Ala Val Pro Glu Ala Ser Ala 
                85                  90                  95      


Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr 
            100                 105                 110         


Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg 
        115                 120                 125             


Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro 
    130                 135                 140                 


Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu 
145                 150                 155                 160 


Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val 
                165                 170                 175     


Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys Pro Pro Lys Lys 
            180                 185                 190         


Pro Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly Arg Gly Arg Pro 
        195                 200                 205             


Lys Gly Ser Gly Thr Gly Arg Pro Lys Ala Ala Ala Ser Glu Gly Val 
    210                 215                 220                 


Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys Leu Val Val Lys 
225                 230                 235                 240 


Met Pro Phe Gln Ala Ser Pro Gly Gly Lys Gly Glu Gly Gly Gly Ala 
                245                 250                 255     


Thr Thr Ser Ala Gln Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg 
            260                 265                 270         


Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys 
        275                 280                 285             


Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala 
    290                 295                 300                 


Val Lys Glu Ser Ser Ile Arg Ser Val His Glu Thr Val Leu Pro Ile 
305                 310                 315                 320 


Lys Lys Arg Lys Thr Arg Glu Thr Val Ser Ile Glu Val Lys Glu Val 
                325                 330                 335     


Val Lys Pro Leu Leu Val Ser Thr Leu Gly Glu Lys Ser Gly Lys Gly 
            340                 345                 350         


Leu Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser Lys Glu Ser Ser Pro 
        355                 360                 365             


Lys Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro Lys Lys Glu His His 
    370                 375                 380                 


His His His His His Ser Glu Ser Thr Lys Ala Pro Met Pro Leu Leu 
385                 390                 395                 400 


Pro Ser Pro Pro Pro Pro Glu Pro Glu Ser Ser Glu Asp Pro Ile Ser 
                405                 410                 415     


Pro Pro Glu Pro Gln Asp Leu Ser Ser Ser Ile Cys Lys Glu Glu Lys 
            420                 425                 430         


Met Pro Arg Gly Gly Ser Leu Glu Ser Asp Gly Cys Pro Lys Glu Pro 
        435                 440                 445             


Ala Lys Thr Gln Pro Met Val Ala Thr Thr Thr Thr Val Ala Glu Lys 
    450                 455                 460                 


Tyr Lys His Arg Gly Glu Gly Glu Arg Lys Asp Ile Val Ser Ser Ser 
465                 470                 475                 480 


Met Pro Arg Pro Asn Arg Glu Glu Pro Val Asp Ser Arg Thr Pro Val 
                485                 490                 495     


Thr Glu Arg Val Ser 
            500     


<210>  30
<211>  484
<212>  PRT
<213>  Mus musculus

<400>  30

Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys Ser Glu Asp Gln 
1               5                   10                  15      


Asp Leu Gln Gly Leu Arg Asp Lys Pro Leu Lys Phe Lys Lys Ala Lys 
            20                  25                  30          


Lys Asp Lys Lys Glu Asp Lys Glu Gly Lys His Glu Pro Leu Gln Pro 
        35                  40                  45              


Ser Ala His His Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu Thr 
    50                  55                  60                  


Ser Glu Ser Ser Gly Ser Ala Pro Ala Val Pro Glu Ala Ser Ala Ser 
65                  70                  75                  80  


Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr Asp 
                85                  90                  95      


Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys 
            100                 105                 110         


Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln 
        115                 120                 125             


Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu Lys 
    130                 135                 140                 


Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val Thr 
145                 150                 155                 160 


Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys Pro Pro Lys Lys Pro 
                165                 170                 175     


Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly Arg Gly Arg Pro Lys 
            180                 185                 190         


Gly Ser Gly Thr Gly Arg Pro Lys Ala Ala Ala Ser Glu Gly Val Gln 
        195                 200                 205             


Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys Leu Val Val Lys Met 
    210                 215                 220                 


Pro Phe Gln Ala Ser Pro Gly Gly Lys Gly Glu Gly Gly Gly Ala Thr 
225                 230                 235                 240 


Thr Ser Ala Gln Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg Lys 
                245                 250                 255     


Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys Pro 
            260                 265                 270         


Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala Val 
        275                 280                 285             


Lys Glu Ser Ser Ile Arg Ser Val His Glu Thr Val Leu Pro Ile Lys 
    290                 295                 300                 


Lys Arg Lys Thr Arg Glu Thr Val Ser Ile Glu Val Lys Glu Val Val 
305                 310                 315                 320 


Lys Pro Leu Leu Val Ser Thr Leu Gly Glu Lys Ser Gly Lys Gly Leu 
                325                 330                 335     


Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser Lys Glu Ser Ser Pro Lys 
            340                 345                 350         


Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro Lys Lys Glu His His His 
        355                 360                 365             


His His His His Ser Glu Ser Thr Lys Ala Pro Met Pro Leu Leu Pro 
    370                 375                 380                 


Ser Pro Pro Pro Pro Glu Pro Glu Ser Ser Glu Asp Pro Ile Ser Pro 
385                 390                 395                 400 


Pro Glu Pro Gln Asp Leu Ser Ser Ser Ile Cys Lys Glu Glu Lys Met 
                405                 410                 415     


Pro Arg Gly Gly Ser Leu Glu Ser Asp Gly Cys Pro Lys Glu Pro Ala 
            420                 425                 430         


Lys Thr Gln Pro Met Val Ala Thr Thr Thr Thr Val Ala Glu Lys Tyr 
        435                 440                 445             


Lys His Arg Gly Glu Gly Glu Arg Lys Asp Ile Val Ser Ser Ser Met 
    450                 455                 460                 


Pro Arg Pro Asn Arg Glu Glu Pro Val Asp Ser Arg Thr Pro Val Thr 
465                 470                 475                 480 


Glu Arg Val Ser 
                


<210>  31
<211>  1452
<212>  DNA
<213>  Mus musculus

<400>  31
atggtagctg ggatgttagg gctcagggag gaaaagtcag aagaccagga tctccagggc       60

ctcagagaca agccactgaa gtttaagaag gcgaagaaag acaagaagga ggacaaagaa      120

ggcaagcatg agccactaca accttcagcc caccattctg cagagccagc agaggcaggc      180

aaagcagaaa catcagaaag ctcaggctct gccccagcag tgccagaagc ctcggcttcc      240

cccaaacagc ggcgctccat tatccgtgac cggggaccta tgtatgatga ccccaccttg      300

cctgaaggtt ggacacgaaa gcttaaacaa aggaagtctg gccgatctgc tggaaagtat      360

gatgtatatt tgatcaatcc ccagggaaaa gcttttcgct ctaaagtaga attgattgca      420

tactttgaaa aggtgggaga cacctccttg gaccctaatg attttgactt cacggtaact      480

gggagaggga gcccctccag gagagagcag aaaccaccta agaagcccaa atctcccaaa      540

gctccaggaa ctggcagggg tcggggacgc cccaaaggga gcggcactgg gagaccaaag      600

gcagcagcat cagaaggtgt tcaggtgaaa agggtcctgg agaagagccc tgggaaactt      660

gttgtcaaga tgcctttcca agcatcgcct gggggtaagg gtgagggagg tggggctacc      720

acatctgccc aggtcatggt gatcaaacgc cctggcagaa agcgaaaagc tgaagctgac      780

ccccaggcca ttcctaagaa acggggtaga aagcctggga gtgtggtggc agctgctgca      840

gctgaggcca aaaagaaagc cgtgaaggag tcttccatac ggtctgtgca tgagactgtg      900

ctccccatca agaagcgcaa gacccgggag acggtcagca tcgaggtcaa ggaagtggtg      960

aagcccctgc tggtgtccac ccttggtgag aaaagcggga agggactgaa gacctgcaag     1020

agccctgggc gtaaaagcaa ggagagcagc cccaaggggc gcagcagcag tgcctcctcc     1080

ccacctaaga aggagcacca tcatcaccac catcactcag agtccacaaa ggcccccatg     1140

ccactgctcc catccccacc cccacctgag cctgagagct ctgaggaccc catcagcccc     1200

cctgagcctc aggacttgag cagcagcatc tgcaaagaag agaagatgcc ccgaggaggc     1260

tcactggaaa gcgatggctg ccccaaggag ccagctaaga ctcagcctat ggtcgccacc     1320

actaccacag ttgcagaaaa gtacaaacac cgaggggagg gagagcgcaa agacattgtt     1380

tcatcttcca tgccaaggcc aaacagagag gagcctgtgg acagccggac gcccgtgacc     1440

gagagagtta gc                                                         1452


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localisation sequence (NLS) polypeptide

<400>  32

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide sequence encoding NLS

<400>  33
cccaagaaaa agcggaaggt g                                                 21


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker polypeptide sequence

<400>  34

Gly Ser Ser Gly Ser Ser Gly 
1               5           


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide sequence encoding linker

<400>  35
ggatccagtg gcagctctgg g                                                 21


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker polypeptide sequence

<400>  36

Cys Lys Asp Pro Pro Val Ala Thr 
1               5               


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide sequence encoding linker

<400>  37
tgtaaggatc caccggtcgc cacc                                              24


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide sequence

<400>  38

Gly Ser Ser Gly Ser Ser Gly 
1               5           


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide sequence encoding linker

<400>  39
gggagctccg gcagttctgg a                                                 21


<210>  40
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse WT e1 with EGFP tag polypeptide 

<400>  40

Met Ala Ala Ala Ala Ala Thr Ala Ala Ala Ala Ala Ala Pro Ser Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Glu Glu Glu Arg Leu Glu Glu Lys Ser Glu Asp 
            20                  25                  30          


Gln Asp Leu Gln Gly Leu Arg Asp Lys Pro Leu Lys Phe Lys Lys Ala 
        35                  40                  45              


Lys Lys Asp Lys Lys Glu Asp Lys Glu Gly Lys His Glu Pro Leu Gln 
    50                  55                  60                  


Pro Ser Ala His His Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu 
65                  70                  75                  80  


Thr Ser Glu Ser Ser Gly Ser Ala Pro Ala Val Pro Glu Ala Ser Ala 
                85                  90                  95      


Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr 
            100                 105                 110         


Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg 
        115                 120                 125             


Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro 
    130                 135                 140                 


Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu 
145                 150                 155                 160 


Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val 
                165                 170                 175     


Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys Pro Pro Lys Lys 
            180                 185                 190         


Pro Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly Arg Gly Arg Pro 
        195                 200                 205             


Lys Gly Ser Gly Thr Gly Arg Pro Lys Ala Ala Ala Ser Glu Gly Val 
    210                 215                 220                 


Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys Leu Val Val Lys 
225                 230                 235                 240 


Met Pro Phe Gln Ala Ser Pro Gly Gly Lys Gly Glu Gly Gly Gly Ala 
                245                 250                 255     


Thr Thr Ser Ala Gln Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg 
            260                 265                 270         


Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys 
        275                 280                 285             


Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala 
    290                 295                 300                 


Val Lys Glu Ser Ser Ile Arg Ser Val His Glu Thr Val Leu Pro Ile 
305                 310                 315                 320 


Lys Lys Arg Lys Thr Arg Glu Thr Val Ser Ile Glu Val Lys Glu Val 
                325                 330                 335     


Val Lys Pro Leu Leu Val Ser Thr Leu Gly Glu Lys Ser Gly Lys Gly 
            340                 345                 350         


Leu Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser Lys Glu Ser Ser Pro 
        355                 360                 365             


Lys Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro Lys Lys Glu His His 
    370                 375                 380                 


His His His His His Ser Glu Ser Thr Lys Ala Pro Met Pro Leu Leu 
385                 390                 395                 400 


Pro Ser Pro Pro Pro Pro Glu Pro Glu Ser Ser Glu Asp Pro Ile Ser 
                405                 410                 415     


Pro Pro Glu Pro Gln Asp Leu Ser Ser Ser Ile Cys Lys Glu Glu Lys 
            420                 425                 430         


Met Pro Arg Gly Gly Ser Leu Glu Ser Asp Gly Cys Pro Lys Glu Pro 
        435                 440                 445             


Ala Lys Thr Gln Pro Met Val Ala Thr Thr Thr Thr Val Ala Glu Lys 
    450                 455                 460                 


Tyr Lys His Arg Gly Glu Gly Glu Arg Lys Asp Ile Val Ser Ser Ser 
465                 470                 475                 480 


Met Pro Arg Pro Asn Arg Glu Glu Pro Val Asp Ser Arg Thr Pro Val 
                485                 490                 495     


Thr Glu Arg Val Ser Cys Lys Asp Pro Pro Val Ala Thr Met Val Ser 
            500                 505                 510         


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
        515                 520                 525             


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
    530                 535                 540                 


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
545                 550                 555                 560 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr 
                565                 570                 575     


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
            580                 585                 590         


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
        595                 600                 605             


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
    610                 615                 620                 


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
625                 630                 635                 640 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
                645                 650                 655     


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
            660                 665                 670         


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
        675                 680                 685             


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
    690                 695                 700                 


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
705                 710                 715                 720 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
                725                 730                 735     


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            740                 745             


<210>  41
<211>  689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse dN e1 with EGFP tag polypeptide

<400>  41

Met Ala Ala Ala Ala Ala Thr Ala Ala Ala Ala Ala Ala Pro Ser Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Glu Glu Glu Arg Leu Glu Glu Lys Pro Ala Val 
            20                  25                  30          


Pro Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp 
        35                  40                  45              


Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg 
    50                  55                  60                  


Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val 
65                  70                  75                  80  


Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu 
                85                  90                  95      


Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp 
            100                 105                 110         


Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln 
        115                 120                 125             


Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg 
    130                 135                 140                 


Gly Arg Gly Arg Pro Lys Gly Ser Gly Thr Gly Arg Pro Lys Ala Ala 
145                 150                 155                 160 


Ala Ser Glu Gly Val Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly 
                165                 170                 175     


Lys Leu Val Val Lys Met Pro Phe Gln Ala Ser Pro Gly Gly Lys Gly 
            180                 185                 190         


Glu Gly Gly Gly Ala Thr Thr Ser Ala Gln Val Met Val Ile Lys Arg 
        195                 200                 205             


Pro Gly Arg Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys 
    210                 215                 220                 


Lys Arg Gly Arg Lys Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu 
225                 230                 235                 240 


Ala Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser Val His Glu 
                245                 250                 255     


Thr Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr Val Ser Ile 
            260                 265                 270         


Glu Val Lys Glu Val Val Lys Pro Leu Leu Val Ser Thr Leu Gly Glu 
        275                 280                 285             


Lys Ser Gly Lys Gly Leu Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser 
    290                 295                 300                 


Lys Glu Ser Ser Pro Lys Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro 
305                 310                 315                 320 


Lys Lys Glu His His His His His His His Ser Glu Ser Thr Lys Ala 
                325                 330                 335     


Pro Met Pro Leu Leu Pro Ser Pro Pro Pro Pro Glu Pro Glu Ser Ser 
            340                 345                 350         


Glu Asp Pro Ile Ser Pro Pro Glu Pro Gln Asp Leu Ser Ser Ser Ile 
        355                 360                 365             


Cys Lys Glu Glu Lys Met Pro Arg Gly Gly Ser Leu Glu Ser Asp Gly 
    370                 375                 380                 


Cys Pro Lys Glu Pro Ala Lys Thr Gln Pro Met Val Ala Thr Thr Thr 
385                 390                 395                 400 


Thr Val Ala Glu Lys Tyr Lys His Arg Gly Glu Gly Glu Arg Lys Asp 
                405                 410                 415     


Ile Val Ser Ser Ser Met Pro Arg Pro Asn Arg Glu Glu Pro Val Asp 
            420                 425                 430         


Ser Arg Thr Pro Val Thr Glu Arg Val Ser Cys Lys Asp Pro Pro Val 
        435                 440                 445             


Ala Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
    450                 455                 460                 


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
465                 470                 475                 480 


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
                485                 490                 495     


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
            500                 505                 510         


Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His 
        515                 520                 525             


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
    530                 535                 540                 


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
545                 550                 555                 560 


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
                565                 570                 575     


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
            580                 585                 590         


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
        595                 600                 605             


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
    610                 615                 620                 


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
625                 630                 635                 640 


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
                645                 650                 655     


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
            660                 665                 670         


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
        675                 680                 685             


Lys 
    


<210>  42
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse dNC e1 with EGFP tag polypeptide

<400>  42

Met Ala Ala Ala Ala Ala Thr Ala Ala Ala Ala Ala Ala Pro Ser Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Glu Glu Glu Arg Leu Glu Glu Lys Pro Ala Val 
            20                  25                  30          


Pro Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp 
        35                  40                  45              


Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg 
    50                  55                  60                  


Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val 
65                  70                  75                  80  


Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu 
                85                  90                  95      


Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp 
            100                 105                 110         


Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln 
        115                 120                 125             


Lys Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg 
    130                 135                 140                 


Gly Arg Gly Arg Pro Lys Gly Ser Gly Thr Gly Arg Pro Lys Ala Ala 
145                 150                 155                 160 


Ala Ser Glu Gly Val Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly 
                165                 170                 175     


Lys Leu Val Val Lys Met Pro Phe Gln Ala Ser Pro Gly Gly Lys Gly 
            180                 185                 190         


Glu Gly Gly Gly Ala Thr Thr Ser Ala Gln Val Met Val Ile Lys Arg 
        195                 200                 205             


Pro Gly Arg Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys 
    210                 215                 220                 


Lys Arg Gly Arg Lys Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu 
225                 230                 235                 240 


Ala Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser Val His Glu 
                245                 250                 255     


Thr Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr Val Gly Ser 
            260                 265                 270         


Ser Gly Ser Ser Gly Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly 
        275                 280                 285             


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
    290                 295                 300                 


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
305                 310                 315                 320 


Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
                325                 330                 335     


Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr 
            340                 345                 350         


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
        355                 360                 365             


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
    370                 375                 380                 


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
385                 390                 395                 400 


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
                405                 410                 415     


His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala 
            420                 425                 430         


Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn 
        435                 440                 445             


Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
    450                 455                 460                 


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
465                 470                 475                 480 


Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
                485                 490                 495     


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
            500                 505                 510         


Glu Leu Tyr Lys 
        515     


<210>  43
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse dNIC e1 with EGFP tag polypeptide

<400>  43

Met Ala Ala Ala Ala Ala Thr Ala Ala Ala Ala Ala Ala Pro Ser Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Glu Glu Glu Arg Leu Glu Glu Lys Pro Ala Val 
            20                  25                  30          


Pro Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp 
        35                  40                  45              


Arg Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg 
    50                  55                  60                  


Lys Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val 
65                  70                  75                  80  


Tyr Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu 
                85                  90                  95      


Ile Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp 
            100                 105                 110         


Phe Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln 
        115                 120                 125             


Lys Pro Pro Gly Ser Ser Gly Ser Ser Gly Pro Lys Lys Lys Arg Lys 
    130                 135                 140                 


Val Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys 
145                 150                 155                 160 


Ala Val Lys Glu Ser Ser Ile Arg Ser Val His Glu Thr Val Leu Pro 
                165                 170                 175     


Ile Lys Lys Arg Lys Thr Arg Glu Thr Val Gly Ser Ser Gly Ser Ser 
            180                 185                 190         


Gly Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
        195                 200                 205             


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
    210                 215                 220                 


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
225                 230                 235                 240 


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
                245                 250                 255     


Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
            260                 265                 270         


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
        275                 280                 285             


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
    290                 295                 300                 


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
305                 310                 315                 320 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
                325                 330                 335     


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
            340                 345                 350         


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
        355                 360                 365             


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
    370                 375                 380                 


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
385                 390                 395                 400 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
                405                 410                 415     


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            420                 425                 430         


<210>  44
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse WT e2 with EGFP tag polypeptide

<400>  44

Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys Ser Glu Asp Gln 
1               5                   10                  15      


Asp Leu Gln Gly Leu Arg Asp Lys Pro Leu Lys Phe Lys Lys Ala Lys 
            20                  25                  30          


Lys Asp Lys Lys Glu Asp Lys Glu Gly Lys His Glu Pro Leu Gln Pro 
        35                  40                  45              


Ser Ala His His Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu Thr 
    50                  55                  60                  


Ser Glu Ser Ser Gly Ser Ala Pro Ala Val Pro Glu Ala Ser Ala Ser 
65                  70                  75                  80  


Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr Asp 
                85                  90                  95      


Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys 
            100                 105                 110         


Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln 
        115                 120                 125             


Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu Lys 
    130                 135                 140                 


Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val Thr 
145                 150                 155                 160 


Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys Pro Pro Lys Lys Pro 
                165                 170                 175     


Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly Arg Gly Arg Pro Lys 
            180                 185                 190         


Gly Ser Gly Thr Gly Arg Pro Lys Ala Ala Ala Ser Glu Gly Val Gln 
        195                 200                 205             


Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys Leu Val Val Lys Met 
    210                 215                 220                 


Pro Phe Gln Ala Ser Pro Gly Gly Lys Gly Glu Gly Gly Gly Ala Thr 
225                 230                 235                 240 


Thr Ser Ala Gln Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg Lys 
                245                 250                 255     


Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys Pro 
            260                 265                 270         


Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala Val 
        275                 280                 285             


Lys Glu Ser Ser Ile Arg Ser Val His Glu Thr Val Leu Pro Ile Lys 
    290                 295                 300                 


Lys Arg Lys Thr Arg Glu Thr Val Ser Ile Glu Val Lys Glu Val Val 
305                 310                 315                 320 


Lys Pro Leu Leu Val Ser Thr Leu Gly Glu Lys Ser Gly Lys Gly Leu 
                325                 330                 335     


Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser Lys Glu Ser Ser Pro Lys 
            340                 345                 350         


Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro Lys Lys Glu His His His 
        355                 360                 365             


His His His His Ser Glu Ser Thr Lys Ala Pro Met Pro Leu Leu Pro 
    370                 375                 380                 


Ser Pro Pro Pro Pro Glu Pro Glu Ser Ser Glu Asp Pro Ile Ser Pro 
385                 390                 395                 400 


Pro Glu Pro Gln Asp Leu Ser Ser Ser Ile Cys Lys Glu Glu Lys Met 
                405                 410                 415     


Pro Arg Gly Gly Ser Leu Glu Ser Asp Gly Cys Pro Lys Glu Pro Ala 
            420                 425                 430         


Lys Thr Gln Pro Met Val Ala Thr Thr Thr Thr Val Ala Glu Lys Tyr 
        435                 440                 445             


Lys His Arg Gly Glu Gly Glu Arg Lys Asp Ile Val Ser Ser Ser Met 
    450                 455                 460                 


Pro Arg Pro Asn Arg Glu Glu Pro Val Asp Ser Arg Thr Pro Val Thr 
465                 470                 475                 480 


Glu Arg Val Ser Cys Lys Asp Pro Pro Val Ala Thr Met Val Ser Lys 
                485                 490                 495     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            500                 505                 510         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        515                 520                 525             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    530                 535                 540                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
545                 550                 555                 560 


Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                565                 570                 575     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            580                 585                 590         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        595                 600                 605             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    610                 615                 620                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
625                 630                 635                 640 


His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val 
                645                 650                 655     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
            660                 665                 670         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        675                 680                 685             


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro 
    690                 695                 700                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
705                 710                 715                 720 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                725                 730     


<210>  45
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse dN e2 with EGFP tag polypeptide

<400>  45

Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys Pro Ala Val Pro 
1               5                   10                  15      


Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg 
            20                  25                  30          


Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys 
        35                  40                  45              


Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr 
    50                  55                  60                  


Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile 
65                  70                  75                  80  


Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe 
                85                  90                  95      


Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys 
            100                 105                 110         


Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly 
        115                 120                 125             


Arg Gly Arg Pro Lys Gly Ser Gly Thr Gly Arg Pro Lys Ala Ala Ala 
    130                 135                 140                 


Ser Glu Gly Val Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys 
145                 150                 155                 160 


Leu Val Val Lys Met Pro Phe Gln Ala Ser Pro Gly Gly Lys Gly Glu 
                165                 170                 175     


Gly Gly Gly Ala Thr Thr Ser Ala Gln Val Met Val Ile Lys Arg Pro 
            180                 185                 190         


Gly Arg Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys 
        195                 200                 205             


Arg Gly Arg Lys Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala 
    210                 215                 220                 


Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser Val His Glu Thr 
225                 230                 235                 240 


Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr Val Ser Ile Glu 
                245                 250                 255     


Val Lys Glu Val Val Lys Pro Leu Leu Val Ser Thr Leu Gly Glu Lys 
            260                 265                 270         


Ser Gly Lys Gly Leu Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser Lys 
        275                 280                 285             


Glu Ser Ser Pro Lys Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro Lys 
    290                 295                 300                 


Lys Glu His His His His His His His Ser Glu Ser Thr Lys Ala Pro 
305                 310                 315                 320 


Met Pro Leu Leu Pro Ser Pro Pro Pro Pro Glu Pro Glu Ser Ser Glu 
                325                 330                 335     


Asp Pro Ile Ser Pro Pro Glu Pro Gln Asp Leu Ser Ser Ser Ile Cys 
            340                 345                 350         


Lys Glu Glu Lys Met Pro Arg Gly Gly Ser Leu Glu Ser Asp Gly Cys 
        355                 360                 365             


Pro Lys Glu Pro Ala Lys Thr Gln Pro Met Val Ala Thr Thr Thr Thr 
    370                 375                 380                 


Val Ala Glu Lys Tyr Lys His Arg Gly Glu Gly Glu Arg Lys Asp Ile 
385                 390                 395                 400 


Val Ser Ser Ser Met Pro Arg Pro Asn Arg Glu Glu Pro Val Asp Ser 
                405                 410                 415     


Arg Thr Pro Val Thr Glu Arg Val Ser Cys Lys Asp Pro Pro Val Ala 
            420                 425                 430         


Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
        435                 440                 445             


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
    450                 455                 460                 


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
465                 470                 475                 480 


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
                485                 490                 495     


Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
            500                 505                 510         


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
        515                 520                 525             


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
    530                 535                 540                 


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
545                 550                 555                 560 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
                565                 570                 575     


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
            580                 585                 590         


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
        595                 600                 605             


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
    610                 615                 620                 


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
625                 630                 635                 640 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
                645                 650                 655     


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            660                 665                 670         


<210>  46
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse dNC e2 with EGFP tag polypeptide

<400>  46

Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys Pro Ala Val Pro 
1               5                   10                  15      


Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg 
            20                  25                  30          


Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys 
        35                  40                  45              


Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr 
    50                  55                  60                  


Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile 
65                  70                  75                  80  


Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe 
                85                  90                  95      


Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys 
            100                 105                 110         


Pro Pro Lys Lys Pro Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly 
        115                 120                 125             


Arg Gly Arg Pro Lys Gly Ser Gly Thr Gly Arg Pro Lys Ala Ala Ala 
    130                 135                 140                 


Ser Glu Gly Val Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys 
145                 150                 155                 160 


Leu Val Val Lys Met Pro Phe Gln Ala Ser Pro Gly Gly Lys Gly Glu 
                165                 170                 175     


Gly Gly Gly Ala Thr Thr Ser Ala Gln Val Met Val Ile Lys Arg Pro 
            180                 185                 190         


Gly Arg Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys 
        195                 200                 205             


Arg Gly Arg Lys Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala 
    210                 215                 220                 


Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser Val His Glu Thr 
225                 230                 235                 240 


Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu Thr Val Gly Ser Ser 
                245                 250                 255     


Gly Ser Ser Gly Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
            260                 265                 270         


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
        275                 280                 285             


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
    290                 295                 300                 


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
305                 310                 315                 320 


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
                325                 330                 335     


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
            340                 345                 350         


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
        355                 360                 365             


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
    370                 375                 380                 


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
385                 390                 395                 400 


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
                405                 410                 415     


Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
            420                 425                 430         


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
        435                 440                 445             


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
    450                 455                 460                 


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
465                 470                 475                 480 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
                485                 490                 495     


Leu Tyr Lys 
            


<210>  47
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse dNIC e2 with EGFP tag polypeptide

<400>  47

Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys Pro Ala Val Pro 
1               5                   10                  15      


Glu Ala Ser Ala Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg 
            20                  25                  30          


Gly Pro Met Tyr Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys 
        35                  40                  45              


Leu Lys Gln Arg Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr 
    50                  55                  60                  


Leu Ile Asn Pro Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile 
65                  70                  75                  80  


Ala Tyr Phe Glu Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe 
                85                  90                  95      


Asp Phe Thr Val Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys 
            100                 105                 110         


Pro Pro Gly Ser Ser Gly Ser Ser Gly Pro Lys Lys Lys Arg Lys Val 
        115                 120                 125             


Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala 
    130                 135                 140                 


Val Lys Glu Ser Ser Ile Arg Ser Val His Glu Thr Val Leu Pro Ile 
145                 150                 155                 160 


Lys Lys Arg Lys Thr Arg Glu Thr Val Gly Ser Ser Gly Ser Ser Gly 
                165                 170                 175     


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
            180                 185                 190         


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
        195                 200                 205             


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
    210                 215                 220                 


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
225                 230                 235                 240 


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
                245                 250                 255     


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
            260                 265                 270         


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
        275                 280                 285             


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
    290                 295                 300                 


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
305                 310                 315                 320 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
                325                 330                 335     


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
            340                 345                 350         


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
        355                 360                 365             


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
    370                 375                 380                 


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
385                 390                 395                 400 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                405                 410                 415 


<210>  48
<211>  2274
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse WT  e1 with EGFP tag cDNA

<400>  48
atggccgccg ctgccgccac cgccgccgcc gccgccgcgc cgagcggagg aggaggagga       60

ggcgaggagg agagactgga ggaaaagtca gaagaccagg atctccaggg cctcagagac      120

aagccactga agtttaagaa ggcgaagaaa gacaagaagg aggacaaaga aggcaagcat      180

gagccactac aaccttcagc ccaccattct gcagagccag cagaggcagg caaagcagaa      240

acatcagaaa gctcaggctc tgccccagca gtgccagaag cctcggcttc ccccaaacag      300

cggcgctcca ttatccgtga ccggggacct atgtatgatg accccacctt gcctgaaggt      360

tggacacgaa agcttaaaca aaggaagtct ggccgatctg ctggaaagta tgatgtatat      420

ttgatcaatc cccagggaaa agcttttcgc tctaaagtag aattgattgc atactttgaa      480

aaggtgggag acacctcctt ggaccctaat gattttgact tcacggtaac tgggagaggg      540

agcccctcca ggagagagca gaaaccacct aagaagccca aatctcccaa agctccagga      600

actggcaggg gtcggggacg ccccaaaggg agcggcactg ggagaccaaa ggcagcagca      660

tcagaaggtg ttcaggtgaa aagggtcctg gagaagagcc ctgggaaact tgttgtcaag      720

atgcctttcc aagcatcgcc tgggggtaag ggtgagggag gtggggctac cacatctgcc      780

caggtcatgg tgatcaaacg ccctggcaga aagcgaaaag ctgaagctga cccccaggcc      840

attcctaaga aacggggtag aaagcctggg agtgtggtgg cagctgctgc agctgaggcc      900

aaaaagaaag ccgtgaagga gtcttccata cggtctgtgc atgagactgt gctccccatc      960

aagaagcgca agacccggga gacggtcagc atcgaggtca aggaagtggt gaagcccctg     1020

ctggtgtcca cccttggtga gaaaagcggg aagggactga agacctgcaa gagccctggg     1080

cgtaaaagca aggagagcag ccccaagggg cgcagcagca gtgcctcctc cccacctaag     1140

aaggagcacc atcatcacca ccatcactca gagtccacaa aggcccccat gccactgctc     1200

ccatccccac ccccacctga gcctgagagc tctgaggacc ccatcagccc ccctgagcct     1260

caggacttga gcagcagcat ctgcaaagaa gagaagatgc cccgaggagg ctcactggaa     1320

agcgatggct gccccaagga gccagctaag actcagccta tggtcgccac cactaccaca     1380

gttgcagaaa agtacaaaca ccgaggggag ggagagcgca aagacattgt ttcatcttcc     1440

atgccaaggc caaacagaga ggagcctgtg gacagccgga cgcccgtgac cgagagagtt     1500

agctgtaagg atccaccggt cgccaccatg gtgagcaagg gcgaggagct gttcaccggg     1560

gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc     1620

ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat ctgcaccacc     1680

ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg cgtgcagtgc     1740

ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa     1800

ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc     1860

gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc     1920

aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag ccacaacgtc     1980

tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat ccgccacaac     2040

atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc catcggcgac     2100

ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct gagcaaagac     2160

cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc cgggatcact     2220

ctcggcatgg acgagctgta caagtaactc ggcatggacg agctgtacaa gtaa           2274


<210>  49
<211>  2070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse dN  e1 with EGFP tag cDNA

<400>  49
atggccgccg ctgccgccac cgccgccgcc gccgccgcgc cgagcggagg aggaggagga       60

ggcgaggagg agagactgga ggaaaagcca gcagtgccag aagcctcggc ttcccccaaa      120

cagcggcgct ccattatccg tgaccgggga cctatgtatg atgaccccac cttgcctgaa      180

ggttggacac gaaagcttaa acaaaggaag tctggccgat ctgctggaaa gtatgatgta      240

tatttgatca atccccaggg aaaagctttt cgctctaaag tagaattgat tgcatacttt      300

gaaaaggtgg gagacacctc cttggaccct aatgattttg acttcacggt aactgggaga      360

gggagcccct ccaggagaga gcagaaacca cctaagaagc ccaaatctcc caaagctcca      420

ggaactggca ggggtcgggg acgccccaaa gggagcggca ctgggagacc aaaggcagca      480

gcatcagaag gtgttcaggt gaaaagggtc ctggagaaga gccctgggaa acttgttgtc      540

aagatgcctt tccaagcatc gcctgggggt aagggtgagg gaggtggggc taccacatct      600

gcccaggtca tggtgatcaa acgccctggc agaaagcgaa aagctgaagc tgacccccag      660

gccattccta agaaacgggg tagaaagcct gggagtgtgg tggcagctgc tgcagctgag      720

gccaaaaaga aagccgtgaa ggagtcttcc atacggtctg tgcatgagac tgtgctcccc      780

atcaagaagc gcaagacccg ggagacggtc agcatcgagg tcaaggaagt ggtgaagccc      840

ctgctggtgt ccacccttgg tgagaaaagc gggaagggac tgaagacctg caagagccct      900

gggcgtaaaa gcaaggagag cagccccaag gggcgcagca gcagtgcctc ctccccacct      960

aagaaggagc accatcatca ccaccatcac tcagagtcca caaaggcccc catgccactg     1020

ctcccatccc cacccccacc tgagcctgag agctctgagg accccatcag cccccctgag     1080

cctcaggact tgagcagcag catctgcaaa gaagagaaga tgccccgagg aggctcactg     1140

gaaagcgatg gctgccccaa ggagccagct aagactcagc ctatggtcgc caccactacc     1200

acagttgcag aaaagtacaa acaccgaggg gagggagagc gcaaagacat tgtttcatct     1260

tccatgccaa ggccaaacag agaggagcct gtggacagcc ggacgcccgt gaccgagaga     1320

gttagctgta aggatccacc ggtcgccacc atggtgagca agggcgagga gctgttcacc     1380

ggggtggtgc ccatcctggt cgagctggac ggcgacgtaa acggccacaa gttcagcgtg     1440

tccggcgagg gcgagggcga tgccacctac ggcaagctga ccctgaagtt catctgcacc     1500

accggcaagc tgcccgtgcc ctggcccacc ctcgtgacca ccctgaccta cggcgtgcag     1560

tgcttcagcc gctaccccga ccacatgaag cagcacgact tcttcaagtc cgccatgccc     1620

gaaggctacg tccaggagcg caccatcttc ttcaaggacg acggcaacta caagacccgc     1680

gccgaggtga agttcgaggg cgacaccctg gtgaaccgca tcgagctgaa gggcatcgac     1740

ttcaaggagg acggcaacat cctggggcac aagctggagt acaactacaa cagccacaac     1800

gtctatatca tggccgacaa gcagaagaac ggcatcaagg tgaacttcaa gatccgccac     1860

aacatcgagg acggcagcgt gcagctcgcc gaccactacc agcagaacac ccccatcggc     1920

gacggccccg tgctgctgcc cgacaaccac tacctgagca cccagtccgc cctgagcaaa     1980

gaccccaacg agaagcgcga tcacatggtc ctgctggagt tcgtgaccgc cgccgggatc     2040

actctcggca tggacgagct gtacaagtaa                                      2070


<210>  50
<211>  1551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse dNC  e1 with EGFP tag cDNA

<400>  50
atggccgccg ctgccgccac cgccgccgcc gccgccgcgc cgagcggagg aggaggagga       60

ggcgaggagg agagactgga ggaaaagcca gcagtgccag aagcctcggc ttcccccaaa      120

cagcggcgct ccattatccg tgaccgggga cctatgtatg atgaccccac cttgcctgaa      180

ggttggacac gaaagcttaa acaaaggaag tctggccgat ctgctggaaa gtatgatgta      240

tatttgatca atccccaggg aaaagctttt cgctctaaag tagaattgat tgcatacttt      300

gaaaaggtgg gagacacctc cttggaccct aatgattttg acttcacggt aactgggaga      360

gggagcccct ccaggagaga gcagaaacca cctaagaagc ccaaatctcc caaagctcca      420

ggaactggca ggggtcgggg acgccccaaa gggagcggca ctgggagacc aaaggcagca      480

gcatcagaag gtgttcaggt gaaaagggtc ctggagaaga gccctgggaa acttgttgtc      540

aagatgcctt tccaagcatc gcctgggggt aagggtgagg gaggtggggc taccacatct      600

gcccaggtca tggtgatcaa acgccctggc agaaagcgaa aagctgaagc tgacccccag      660

gccattccta agaaacgggg tagaaagcct gggagtgtgg tggcagctgc tgcagctgag      720

gccaaaaaga aagccgtgaa ggagtcttcc atacggtctg tgcatgagac tgtgctcccc      780

atcaagaagc gcaagacccg ggagacggtc gggagctccg gcagttctgg aatggtgagc      840

aagggcgagg agctgttcac cggggtggtg cccatcctgg tcgagctgga cggcgacgta      900

aacggccaca agttcagcgt gtccggcgag ggcgagggcg atgccaccta cggcaagctg      960

accctgaagt tcatctgcac caccggcaag ctgcccgtgc cctggcccac cctcgtgacc     1020

accctgacct acggcgtgca gtgcttcagc cgctaccccg accacatgaa gcagcacgac     1080

ttcttcaagt ccgccatgcc cgaaggctac gtccaggagc gcaccatctt cttcaaggac     1140

gacggcaact acaagacccg cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc     1200

atcgagctga agggcatcga cttcaaggag gacggcaaca tcctggggca caagctggag     1260

tacaactaca acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag     1320

gtgaacttca agatccgcca caacatcgag gacggcagcg tgcagctcgc cgaccactac     1380

cagcagaaca cccccatcgg cgacggcccc gtgctgctgc ccgacaacca ctacctgagc     1440

acccagtccg ccctgagcaa agaccccaac gagaagcgcg atcacatggt cctgctggag     1500

ttcgtgaccg ccgccgggat cactctcggc atggacgagc tgtacaagta a              1551


<210>  51
<211>  1299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse dNIC  e1 with EGFP tag cDNA

<400>  51
atggccgccg ctgccgccac cgccgccgcc gccgccgcgc cgagcggagg aggaggagga       60

ggcgaggagg agagactgga ggaaaagcca gcagtgccag aagcctcggc ttcccccaaa      120

cagcggcgct ccattatccg tgaccgggga cctatgtatg atgaccccac cttgcctgaa      180

ggttggacac gaaagcttaa acaaaggaag tctggccgat ctgctggaaa gtatgatgta      240

tatttgatca atccccaggg aaaagctttt cgctctaaag tagaattgat tgcatacttt      300

gaaaaggtgg gagacacctc cttggaccct aatgattttg acttcacggt aactgggaga      360

gggagcccct ccaggagaga gcagaaacca cctggatcca gtggcagctc tgggcccaag      420

aaaaagcgga aggtgcctgg gagtgtggtg gcagctgctg cagctgaggc caaaaagaaa      480

gccgtgaagg agtcttccat acggtctgtg catgagactg tgctccccat caagaagcgc      540

aagacccggg agacggtcgg gagctccggc agttctggaa tggtgagcaa gggcgaggag      600

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag      660

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc      720

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac      780

ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc      840

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac      900

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag      960

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac     1020

agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag     1080

atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc     1140

cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc     1200

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc     1260

gccgggatca ctctcggcat ggacgagctg tacaagtaa                            1299


<210>  52
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse WT  e2 with EGFP tag cDNA

<400>  52
atggtagctg ggatgttagg gctcagggag gaaaagtcag aagaccagga tctccagggc       60

ctcagagaca agccactgaa gtttaagaag gcgaagaaag acaagaagga ggacaaagaa      120

ggcaagcatg agccactaca accttcagcc caccattctg cagagccagc agaggcaggc      180

aaagcagaaa catcagaaag ctcaggctct gccccagcag tgccagaagc ctcggcttcc      240

cccaaacagc ggcgctccat tatccgtgac cggggaccta tgtatgatga ccccaccttg      300

cctgaaggtt ggacacgaaa gcttaaacaa aggaagtctg gccgatctgc tggaaagtat      360

gatgtatatt tgatcaatcc ccagggaaaa gcttttcgct ctaaagtaga attgattgca      420

tactttgaaa aggtgggaga cacctccttg gaccctaatg attttgactt cacggtaact      480

gggagaggga gcccctccag gagagagcag aaaccaccta agaagcccaa atctcccaaa      540

gctccaggaa ctggcagggg tcggggacgc cccaaaggga gcggcactgg gagaccaaag      600

gcagcagcat cagaaggtgt tcaggtgaaa agggtcctgg agaagagccc tgggaaactt      660

gttgtcaaga tgcctttcca agcatcgcct gggggtaagg gtgagggagg tggggctacc      720

acatctgccc aggtcatggt gatcaaacgc cctggcagaa agcgaaaagc tgaagctgac      780

ccccaggcca ttcctaagaa acggggtaga aagcctggga gtgtggtggc agctgctgca      840

gctgaggcca aaaagaaagc cgtgaaggag tcttccatac ggtctgtgca tgagactgtg      900

ctccccatca agaagcgcaa gacccgggag acggtcagca tcgaggtcaa ggaagtggtg      960

aagcccctgc tggtgtccac ccttggtgag aaaagcggga agggactgaa gacctgcaag     1020

agccctgggc gtaaaagcaa ggagagcagc cccaaggggc gcagcagcag tgcctcctcc     1080

ccacctaaga aggagcacca tcatcaccac catcactcag agtccacaaa ggcccccatg     1140

ccactgctcc catccccacc cccacctgag cctgagagct ctgaggaccc catcagcccc     1200

cctgagcctc aggacttgag cagcagcatc tgcaaagaag agaagatgcc ccgaggaggc     1260

tcactggaaa gcgatggctg ccccaaggag ccagctaaga ctcagcctat ggtcgccacc     1320

actaccacag ttgcagaaaa gtacaaacac cgaggggagg gagagcgcaa agacattgtt     1380

tcatcttcca tgccaaggcc aaacagagag gagcctgtgg acagccggac gcccgtgacc     1440

gagagagtta gctgtaagga tccaccggtc gccaccatgg tgagcaaggg cgaggagctg     1500

ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc     1560

agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc     1620

tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc     1680

gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc     1740

atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag     1800

acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc     1860

atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc     1920

cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc     1980

cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc     2040

atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg     2100

agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc     2160

gggatcactc tcggcatgga cgagctgtac aagtaa                               2196


<210>  53
<211>  2019
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse dN  e2 with EGFP tag cDNA

<400>  53
atggtagctg ggatgttagg gctcagggag gaaaagccag cagtgccaga agcctcggct       60

tcccccaaac agcggcgctc cattatccgt gaccggggac ctatgtatga tgaccccacc      120

ttgcctgaag gttggacacg aaagcttaaa caaaggaagt ctggccgatc tgctggaaag      180

tatgatgtat atttgatcaa tccccaggga aaagcttttc gctctaaagt agaattgatt      240

gcatactttg aaaaggtggg agacacctcc ttggacccta atgattttga cttcacggta      300

actgggagag ggagcccctc caggagagag cagaaaccac ctaagaagcc caaatctccc      360

aaagctccag gaactggcag gggtcgggga cgccccaaag ggagcggcac tgggagacca      420

aaggcagcag catcagaagg tgttcaggtg aaaagggtcc tggagaagag ccctgggaaa      480

cttgttgtca agatgccttt ccaagcatcg cctgggggta agggtgaggg aggtggggct      540

accacatctg cccaggtcat ggtgatcaaa cgccctggca gaaagcgaaa agctgaagct      600

gacccccagg ccattcctaa gaaacggggt agaaagcctg ggagtgtggt ggcagctgct      660

gcagctgagg ccaaaaagaa agccgtgaag gagtcttcca tacggtctgt gcatgagact      720

gtgctcccca tcaagaagcg caagacccgg gagacggtca gcatcgaggt caaggaagtg      780

gtgaagcccc tgctggtgtc cacccttggt gagaaaagcg ggaagggact gaagacctgc      840

aagagccctg ggcgtaaaag caaggagagc agccccaagg ggcgcagcag cagtgcctcc      900

tccccaccta agaaggagca ccatcatcac caccatcact cagagtccac aaaggccccc      960

atgccactgc tcccatcccc acccccacct gagcctgaga gctctgagga ccccatcagc     1020

ccccctgagc ctcaggactt gagcagcagc atctgcaaag aagagaagat gccccgagga     1080

ggctcactgg aaagcgatgg ctgccccaag gagccagcta agactcagcc tatggtcgcc     1140

accactacca cagttgcaga aaagtacaaa caccgagggg agggagagcg caaagacatt     1200

gtttcatctt ccatgccaag gccaaacaga gaggagcctg tggacagccg gacgcccgtg     1260

accgagagag ttagctgtaa ggatccaccg gtcgccacca tggtgagcaa gggcgaggag     1320

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag     1380

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc     1440

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac     1500

ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc     1560

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac     1620

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag     1680

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac     1740

agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag     1800

atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc     1860

cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc     1920

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc     1980

gccgggatca ctctcggcat ggacgagctg tacaagtaa                            2019


<210>  54
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse dNC  e2 with EGFP tag cDNA

<400>  54
atggtagctg ggatgttagg gctcagggag gaaaagccag cagtgccaga agcctcggct       60

tcccccaaac agcggcgctc cattatccgt gaccggggac ctatgtatga tgaccccacc      120

ttgcctgaag gttggacacg aaagcttaaa caaaggaagt ctggccgatc tgctggaaag      180

tatgatgtat atttgatcaa tccccaggga aaagcttttc gctctaaagt agaattgatt      240

gcatactttg aaaaggtggg agacacctcc ttggacccta atgattttga cttcacggta      300

actgggagag ggagcccctc caggagagag cagaaaccac ctaagaagcc caaatctccc      360

aaagctccag gaactggcag gggtcgggga cgccccaaag ggagcggcac tgggagacca      420

aaggcagcag catcagaagg tgttcaggtg aaaagggtcc tggagaagag ccctgggaaa      480

cttgttgtca agatgccttt ccaagcatcg cctgggggta agggtgaggg aggtggggct      540

accacatctg cccaggtcat ggtgatcaaa cgccctggca gaaagcgaaa agctgaagct      600

gacccccagg ccattcctaa gaaacggggt agaaagcctg ggagtgtggt ggcagctgct      660

gcagctgagg ccaaaaagaa agccgtgaag gagtcttcca tacggtctgt gcatgagact      720

gtgctcccca tcaagaagcg caagacccgg gagacggtcg ggagctccgg cagttctgga      780

atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac      840

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      900

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      960

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag     1020

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc     1080

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg     1140

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac     1200

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac     1260

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc     1320

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac     1380

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc     1440

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa     1500


<210>  55
<211>  1248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse dNIC e2 with EGFP tag cDNA

<400>  55
atggtagctg ggatgttagg gctcagggag gaaaagccag cagtgccaga agcctcggct       60

tcccccaaac agcggcgctc cattatccgt gaccggggac ctatgtatga tgaccccacc      120

ttgcctgaag gttggacacg aaagcttaaa caaaggaagt ctggccgatc tgctggaaag      180

tatgatgtat atttgatcaa tccccaggga aaagcttttc gctctaaagt agaattgatt      240

gcatactttg aaaaggtggg agacacctcc ttggacccta atgattttga cttcacggta      300

actgggagag ggagcccctc caggagagag cagaaaccac ctggatccag tggcagctct      360

gggcccaaga aaaagcggaa ggtgcctggg agtgtggtgg cagctgctgc agctgaggcc      420

aaaaagaaag ccgtgaagga gtcttccata cggtctgtgc atgagactgt gctccccatc      480

aagaagcgca agacccggga gacggtcggg agctccggca gttctggaat ggtgagcaag      540

ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac      600

ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc      660

ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc      720

ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc      780

ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac      840

ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc      900

gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac      960

aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg     1020

aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag     1080

cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc     1140

cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc     1200

gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaa                  1248


<210>  56
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer: R111G Forward

<400>  56
tggacacgaa agcttaaaca agggaagtct ggcc                                   34


<210>  57
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer: R111G Reverse

<400>  57
ggccagactt cccttgttta agctttcgtg tcca                                   34


<210>  58
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer: R306C Forward

<400>  58
ctcccgggtc ttgcacttct tgatgggga                                         29


<210>  59
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer: R306C Reverse

<400>  59
tccccatcaa gaagtgcaag acccgggag                                         29


<210>  60
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human dNC e1 with Myc tag polypeptide

<400>  60

Met Ala Ala Ala Ala Ala Ala Ala Pro Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Glu Glu Glu Arg Leu Glu Glu Lys Pro Ala Val Pro Glu Ala Ser Ala 
            20                  25                  30          


Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr 
        35                  40                  45              


Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg 
    50                  55                  60                  


Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro 
65                  70                  75                  80  


Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu 
                85                  90                  95      


Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val 
            100                 105                 110         


Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys Pro Pro Lys Lys 
        115                 120                 125             


Pro Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly Arg Gly Arg Pro 
    130                 135                 140                 


Lys Gly Ser Gly Thr Thr Arg Pro Lys Ala Ala Thr Ser Glu Gly Val 
145                 150                 155                 160 


Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys Leu Leu Val Lys 
                165                 170                 175     


Met Pro Phe Gln Thr Ser Pro Gly Gly Lys Ala Glu Gly Gly Gly Ala 
            180                 185                 190         


Thr Thr Ser Thr Gln Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg 
        195                 200                 205             


Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys 
    210                 215                 220                 


Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala 
225                 230                 235                 240 


Val Lys Glu Ser Ser Ile Arg Ser Val Gln Glu Thr Val Leu Pro Ile 
                245                 250                 255     


Lys Lys Arg Lys Thr Arg Glu Thr Val Gly Ser Ser Gly Ser Ser Gly 
            260                 265                 270         


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Val Asp 
        275                 280                 


<210>  61
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human dNIC e1 with Myc tag polypeptide

<400>  61

Met Ala Ala Ala Ala Ala Ala Ala Pro Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Glu Glu Glu Arg Leu Glu Glu Lys Pro Ala Val Pro Glu Ala Ser Ala 
            20                  25                  30          


Ser Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr 
        35                  40                  45              


Asp Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg 
    50                  55                  60                  


Lys Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro 
65                  70                  75                  80  


Gln Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu 
                85                  90                  95      


Lys Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val 
            100                 105                 110         


Thr Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys Pro Pro Gly Ser 
        115                 120                 125             


Ser Gly Ser Ser Gly Pro Lys Lys Lys Arg Lys Val Pro Gly Ser Val 
    130                 135                 140                 


Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala Val Lys Glu Ser 
145                 150                 155                 160 


Ser Ile Arg Ser Val Gln Glu Thr Val Leu Pro Ile Lys Lys Arg Lys 
                165                 170                 175     


Thr Arg Glu Thr Val Gly Ser Ser Gly Ser Ser Gly Glu Gln Lys Leu 
            180                 185                 190         


Ile Ser Glu Glu Asp Leu Val Asp 
        195                 200 


<210>  62
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human dNC e1 with Myc tag cDNA

<400>  62
atggccgccg ccgccgccgc cgcgccgagc ggaggaggag gaggaggcga ggaggagaga       60

ctggaagaaa agccggctgt gccggaagct tctgcctccc ccaaacagcg gcgctccatc      120

atccgtgacc ggggacccat gtatgatgac cccaccctgc ctgaaggctg gacacggaag      180

cttaagcaaa ggaaatctgg ccgctctgct gggaagtatg atgtgtattt gatcaatccc      240

cagggaaaag cctttcgctc taaagtggag ttgattgcgt acttcgaaaa ggtaggcgac      300

acatccctgg accctaatga ttttgacttc acggtaactg ggagagggag cccctcccgg      360

cgagagcaga aaccacctaa gaagcccaaa tctcccaaag ctccaggaac tggcagaggc      420

cggggacgcc ccaaagggag cggcaccacg agacccaagg cggccacgtc agagggtgtg      480

caggtgaaaa gggtcctgga gaaaagtcct gggaagctcc ttgtcaagat gccttttcaa      540

acttcgccag ggggcaaggc tgaggggggt ggggccacca catccaccca ggtcatggtg      600

atcaaacgcc ccggcaggaa gcgaaaagct gaggccgacc ctcaggccat tcccaagaaa      660

cggggccgaa agccggggag tgtggtggca gccgctgccg ccgaggccaa aaagaaagcc      720

gtgaaggagt cttctatccg atctgtgcag gagaccgtac tccccatcaa gaagcgcaag      780

acccgggaga cggtcgggag ctccggcagt tctggagaac aaaaactcat ctcagaagag      840

gatctggtcg actag                                                       855


<210>  63
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human dNIC e1 with Myc tag cDNA

<400>  63
atggccgccg ccgccgccgc cgcgccgagc ggaggaggag gaggaggcga ggaggagaga       60

ctggaagaaa agccggctgt gccggaagct tctgcctccc ccaaacagcg gcgctccatc      120

atccgtgacc ggggacccat gtatgatgac cccaccctgc ctgaaggctg gacacggaag      180

cttaagcaaa ggaaatctgg ccgctctgct gggaagtatg atgtgtattt gatcaatccc      240

cagggaaaag cctttcgctc taaagtggag ttgattgcgt acttcgaaaa ggtaggcgac      300

acatccctgg accctaatga ttttgacttc acggtaactg ggagagggag cccctcccgg      360

cgagagcaga aaccacctgg atccagtggc agctctgggc ccaagaaaaa gcggaaggtg      420

ccggggagtg tggtggcagc cgctgccgcc gaggccaaaa agaaagccgt gaaggagtct      480

tctatccgat ctgtgcagga gaccgtactc cccatcaaga agcgcaagac ccgggagacg      540

gtcgggagct ccggcagttc tggagaacaa aaactcatct cagaagagga tctggtcgac      600

tag                                                                    603


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide sequence RNA

<400>  64
ggttgtgacc cgccatggat                                                   20


<210>  65
<211>  1504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dNIC expression cassette flanked by AAV2 ITRs

<400>  65
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggggttcg gtacccatag      120

gcgccaagag cctagacttc cttaagcgcc agagtccaca agggcccagt taatcctcaa      180

cattcaaatg ctgcccacaa aaccagcccc tctgtgccct agccgcctct tttttccaag      240

tgacagtaga actccaccaa tccgcagctg aatggggtcc gcctcttttc cctgcctaaa      300

cagacaggaa ctcctgccaa ttgagggcgt caccgctaag gctccgcccc agcctgggct      360

ccacaaccaa tgaagggtaa tctcgacaaa gagcaagggg tggggcgcgg gcgcgcaggt      420

gcagcagcac acaggctggt cgggagggcg gggcgcgacg tctgccgtgc ggggtcccgg      480

catcggttgc gcgcgcgctc cctcctctcg gagagagggc tgtggtaaaa cccgtccgga      540

aaccatggcc gccgccgccg ccgccgcgcc gagcggagga ggaggaggag gcgaggagga      600

gagactggaa gaaaagccgg ctgtgccgga agcttctgcc tcccccaaac agcggcgctc      660

catcatccgt gaccggggac ccatgtatga tgaccccacc ctgcctgaag gctggacacg      720

gaagcttaag caaaggaaat ctggccgctc tgctgggaag tatgatgtgt atttgatcaa      780

tccccaggga aaagcctttc gctctaaagt ggagttgatt gcgtacttcg aaaaggtagg      840

cgacacatcc ctggacccta atgattttga cttcacggta actgggagag ggagcccctc      900

ccggcgagag cagaaaccac ctggatccag tggcagctct gggcccaaga aaaagcggaa      960

ggtgccgggg agtgtggtgg cagccgctgc cgccgaggcc aaaaagaaag ccgtgaagga     1020

gtcttctatc cgatctgtgc aggagaccgt actccccatc aagaagcgca agacccggga     1080

gacggtcggg agctccggca gttctggaga acaaaaactc atctcagaag aggatctggt     1140

cgactagagc tcgctgatca gcctcacaag aataaaggca gctgttgtct cttcagaagt     1200

agctttgcac ttttctaaac taggaatatc accaggactg ttactcaatg tgtgggtacc     1260

gaaagcactg atatatttaa aaacaaaagg tgtaacctat ttattatata aagagtttgc     1320

cttataaatt tacataaaaa tgtccgtttg tgtcttttgt tgtaaaaatc acgcgtagga     1380

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg     1440

gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc     1500

gcgc                                                                  1504





