                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF 
       NEURODEGENERATIVE DISEASE

<130>  BIO17059 GIRAULT

<160>  7     

<170>  PatentIn version 3.3

<210>  1
<211>  1009
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Val Gly Thr Leu 
1               5                   10                  15      


Arg Arg Pro Glu Gly Pro Pro Glu Pro Met Val Val Val Pro Val Asp 
            20                  25                  30          


Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn 
        35                  40                  45              


Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln 
    50                  55                  60                  


Thr Glu Ile Gln Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile 
65                  70                  75                  80  


Gly Pro Asn Ile Gln Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His 
                85                  90                  95      


Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly 
            100                 105                 110         


Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg 
        115                 120                 125             


Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu 
    130                 135                 140                 


Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn 
145                 150                 155                 160 


Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu 
                165                 170                 175     


Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His 
            180                 185                 190         


Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val 
        195                 200                 205             


Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro 
    210                 215                 220                 


Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser 
225                 230                 235                 240 


Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly 
                245                 250                 255     


Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly 
            260                 265                 270         


Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln 
        275                 280                 285             


Leu Thr Ser Gln Asp Thr Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln 
    290                 295                 300                 


Ile Lys Ser Ile Arg Cys Leu Pro Leu Glu Glu Thr Gln Ala Val Leu 
305                 310                 315                 320 


Gln Leu Gly Ile Glu Gly Ala Pro Gln Ser Leu Ser Ile Lys Thr Ser 
                325                 330                 335     


Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys 
            340                 345                 350         


Arg Leu Gln Gly Glu His Lys Gly Ser Leu Ile Met His Ala Lys Lys 
        355                 360                 365             


Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Thr Leu Asn Leu 
    370                 375                 380                 


Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp 
385                 390                 395                 400 


Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro 
                405                 410                 415     


Gln Tyr Gly Val Ala Arg Glu Glu Val Val Leu Asn Arg Ile Leu Gly 
            420                 425                 430         


Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys 
        435                 440                 445             


Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr 
    450                 455                 460                 


Gln Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn 
465                 470                 475                 480 


Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu 
                485                 490                 495     


Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His 
            500                 505                 510         


Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Pro Thr Leu Val Leu 
        515                 520                 525             


Tyr Thr Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn 
    530                 535                 540                 


Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro 
545                 550                 555                 560 


Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp 
                565                 570                 575     


Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met 
            580                 585                 590         


Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val 
        595                 600                 605             


Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln 
    610                 615                 620                 


Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys 
625                 630                 635                 640 


Gly Asp Arg Leu Pro Lys Pro Glu Leu Cys Pro Pro Val Leu Tyr Thr 
                645                 650                 655     


Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe 
            660                 665                 670         


Thr Glu Leu Val Cys Ser Leu Ser Asp Ile Tyr Gln Met Glu Lys Asp 
        675                 680                 685             


Ile Ala Ile Glu Gln Glu Arg Asn Ala Arg Tyr Arg Pro Pro Lys Ile 
    690                 695                 700                 


Leu Glu Pro Thr Thr Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro 
705                 710                 715                 720 


Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln 
                725                 730                 735     


Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser 
            740                 745                 750         


Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu 
        755                 760                 765             


His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe 
    770                 775                 780                 


Ile Arg Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu 
785                 790                 795                 800 


Lys Ile Lys Met Lys Gln Val Leu Glu Arg Gln Gln Lys Gln Met Val 
                805                 810                 815     


Glu Asp Ser Gln Trp Leu Arg Arg Glu Glu Arg Cys Leu Asp Pro Met 
            820                 825                 830         


Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Ala Gly 
        835                 840                 845             


Tyr Thr Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala 
    850                 855                 860                 


Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val 
865                 870                 875                 880 


Tyr His Asn Val Met Thr Leu Val Glu Ala Val Leu Glu Leu Lys Asn 
                885                 890                 895     


Lys Leu Gly Gln Leu Pro Pro Glu Asp Tyr Val Val Val Val Lys Asn 
            900                 905                 910         


Val Gly Leu Asn Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu 
        915                 920                 925             


Pro Ser Leu Pro Ala Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys 
    930                 935                 940                 


Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Lys Leu Ala 
945                 950                 955                 960 


Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Asp Cys Lys Arg Gln Met 
                965                 970                 975     


Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp 
            980                 985                 990         


Ala Val Asp Gln Ala Lys Val Val  Ala Asn Leu Ala His  Pro Pro Ala 
        995                 1000                 1005             


Glu 
    


<210>  2
<211>  1009
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu 
1               5                   10                  15      


Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp 
            20                  25                  30          


Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn 
        35                  40                  45              


Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln 
    50                  55                  60                  


Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile 
65                  70                  75                  80  


Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His 
                85                  90                  95      


Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly 
            100                 105                 110         


Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg 
        115                 120                 125             


Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu 
    130                 135                 140                 


Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn 
145                 150                 155                 160 


Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu 
                165                 170                 175     


Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His 
            180                 185                 190         


Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val 
        195                 200                 205             


Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro 
    210                 215                 220                 


Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser 
225                 230                 235                 240 


Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly 
                245                 250                 255     


Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly 
            260                 265                 270         


Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln 
        275                 280                 285             


Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln 
    290                 295                 300                 


Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu 
305                 310                 315                 320 


Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser 
                325                 330                 335     


Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys 
            340                 345                 350         


Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys 
        355                 360                 365             


Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu 
    370                 375                 380                 


Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp 
385                 390                 395                 400 


Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro 
                405                 410                 415     


Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly 
            420                 425                 430         


Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys 
        435                 440                 445             


Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr 
    450                 455                 460                 


Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn 
465                 470                 475                 480 


Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu 
                485                 490                 495     


Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His 
            500                 505                 510         


Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu 
        515                 520                 525             


Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn 
    530                 535                 540                 


Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro 
545                 550                 555                 560 


Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp 
                565                 570                 575     


Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met 
            580                 585                 590         


Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val 
        595                 600                 605             


Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln 
    610                 615                 620                 


Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys 
625                 630                 635                 640 


Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr 
                645                 650                 655     


Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe 
            660                 665                 670         


Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp 
        675                 680                 685             


Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile 
    690                 695                 700                 


Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro 
705                 710                 715                 720 


Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln 
                725                 730                 735     


Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser 
            740                 745                 750         


Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu 
        755                 760                 765             


His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe 
    770                 775                 780                 


Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu 
785                 790                 795                 800 


Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val 
                805                 810                 815     


Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met 
            820                 825                 830         


Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly 
        835                 840                 845             


Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala 
    850                 855                 860                 


Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val 
865                 870                 875                 880 


Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn 
                885                 890                 895     


Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn 
            900                 905                 910         


Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu 
        915                 920                 925             


Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys 
    930                 935                 940                 


Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala 
945                 950                 955                 960 


Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met 
                965                 970                 975     


Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp 
            980                 985                 990         


Ala Val Asp Gln Ala Lys Val Leu  Ala Asn Leu Ala His  Pro Pro Ala 
        995                 1000                 1005             


Glu 
    


<210>  3
<211>  3030
<212>  DNA
<213>  Mus musculus

<400>  3
atgtccgggg tgtctgagcc cttgagccgt gtaaaagtgg gcactttacg ccggcctgag     60

ggccccccag agcccatggt ggtggtacca gtggatgtgg agaaggaaga cgtgcgcatc    120

ctcaaggtct gcttctacag caacagcttc aacccaggga agaacttcaa gcttgtcaaa    180

tgcacagtgc agacagagat ccaggagatc atcacctcca tcctcctgag tgggcgaata    240

gggcccaaca tccagctggc tgaatgctat gggctgaggc tgaagcacat gaagtcagac    300

gagatccact ggctgcaccc acagatgacc gtgggcgaag tgcaggacaa gtatgaatgt    360

ctacacgtgg aagctgagtg gaggtatgac cttcaaatcc gctacttgcc ggaagacttc    420

atggagagcc tgaaagaaga caggaccaca ttgctgtact tttatcaaca gctccggaat    480

gactacatgc aacgctacgc cagcaaggtc agtgaaggca tggctctgca gctgggctgt    540

ctggagctca ggagattctt caaggacatg ccccacaatg cactggacaa aaagtccaac    600

tttgaactcc tggaaaaaga agtcggtctg gacctgtttt tcccaaagca gatgcaggaa    660

aacttaaagc ccaagcagtt ccggaagatg atccagcaga ccttccagca gtatgcatca    720

ctccgggagg aagagtgtgt catgaaattc ttcaataccc tagcgggctt tgccaacatt    780

gaccaggaga cctaccgctg cgaactcatt caaggatgga acattactgt ggacctggtc    840

atcggcccta aaggcatccg tcagctgaca agtcaagata caaagcccac ctgcctggcc    900

gagtttaagc agatcaaatc catcaggtgc ctcccattgg aagagaccca ggcagtcctg    960

cagctgggca tcgagggtgc cccccagtcc ttgtctatca aaacgtcgtc cctggcagag   1020

gctgagaaca tggctgacct catagatggc tactgcaggc tgcaaggaga acataagggc   1080

tctctcatca tgcatgccaa gaaagatggt gagaagagga acagcctgcc tcagatcccc   1140

acactaaacc tggaggctcg gcggtcgcac ctctcagaaa gctgcagcat agagtcagac   1200

atctatgcgg agattcccga tgagaccctg cgaagaccag gaggtccaca gtacggtgtt   1260

gcccgtgaag aagtagttct taaccgcatt ctgggtgaag gcttctttgg ggaggtctat   1320

gaaggtgtct acacgaacca caaaggggaa aaaattaatg tggccgtcaa gacctgtaag   1380

aaagactgta cccaggacaa caaggagaag ttcatgagtg aggcagtgat catgaagaat   1440

cttgaccacc ctcacatcgt gaagctgatt ggcatcattg aagaggaacc cacctggatt   1500

atcatggaac tgtatcctta tggggagctg ggacactacc tggaacgaaa taaaaactcc   1560

ctgaaggtac ccactctggt cctgtacacc ctacagatat gcaaagccat ggcctatctg   1620

gagagcatca actgtgtgca cagggatatt gctgtccgga acatcctggt ggcctctcct   1680

gagtgtgtga agctggggga ctttgggctc tcccggtaca ttgaggacga agactattac   1740

aaagcctctg tgacccgtct acccatcaaa tggatgtccc ccgagtccat caacttccgc   1800

cgcttcacaa ccgccagtga tgtctggatg tttgctgtat gcatgtggga gatcctcagc   1860

tttgggaagc agcctttctt ctggctcgaa aataaggatg tcatcggagt gctggagaaa   1920

ggggacaggc tgcccaagcc cgaactctgt ccgcctgtcc tttacacact catgactcgc   1980

tgctgggact acgaccccag tgaccggccc cgcttcacgg agcttgtgtg cagcctcagt   2040

gacatttatc agatggagaa ggacattgcc atagagcaag aaaggaatgc tcgctaccga   2100

ccccccaaaa tattggagcc tactaccttt caggaacccc cacccaagcc cagccggccc   2160

aagtacagac ctcctccaca gaccaacctg ctggctccta agctgcagtt ccaggtccct   2220

gagggtctgt gtgccagctc tcctacgctt accagcccta tggagtatcc atctccagtt   2280

aactcgctac acaccccacc tctccaccgg cacaatgtct tcaagcgcca cagcatgcgg   2340

gaggaggact tcatccggcc cagtagccga gaagaggccc agcagctctg ggaggcagag   2400

aagatcaaga tgaagcaggt cctagaaaga cagcagaagc agatggtgga agattcccag   2460

tggctgaggc gagaggaaag atgcttggac cctatggttt atatgaatga caagtcccca   2520

ctgactccag agaaggaggc cggctacacg gagttcacag ggcccccaca gaaaccacct   2580

cggctcggtg cacagtccat tcagcccaca gccaacctgg acaggaccga tgacctcgtg   2640

taccacaatg tcatgaccct ggtggaggct gtgctggaac tcaagaacaa gcttggccag   2700

ttgccccctg aggactatgt ggtggtggtg aagaacgtgg ggctgaacct gcggaagctc   2760

atcggcagtg tggacgatct cttgccctcc ttgccggcat cttcgaggac agagattgaa   2820

gggacccaga aactgctcaa caaagacctg gcagagctca tcaacaagat gaagttggct   2880

cagcagaacg ccgtgacgtc cctgagtgag gactgcaagc ggcagatgct cacagcgtcc   2940

cataccctgg ctgtggatgc caagaacctg ctggatgctg tggaccaagc caaggttgtg   3000

gctaatctgg cccacccgcc tgcagagtga                                    3030


<210>  4
<211>  3030
<212>  DNA
<213>  Homo sapiens

<400>  4
atgtctgggg tgtccgagcc cctgagccga gtaaagttgg gcacattacg ccggcctgaa     60

ggccctgcag agcccatggt ggtggtacca gtagatgtgg aaaaggagga cgtgcgtatc    120

ctcaaggtct gcttctatag caacagcttc aatcctggga agaacttcaa actggtcaaa    180

tgcactgtcc agacggagat ccgggagatc atcacctcca tcctgctgag cgggcggatc    240

gggcccaaca tccggttggc tgagtgctat gggctgaggc tgaagcacat gaagtccgat    300

gagatccact ggctgcaccc acagatgacg gtgggtgagg tgcaggacaa gtatgagtgt    360

ctgcacgtgg aagccgagtg gaggtatgac cttcaaatcc gctacttgcc agaagacttc    420

atggagagcc tgaaggagga caggaccacg ctgctctatt tttaccaaca gctccggaac    480

gactacatgc agcgctacgc cagcaaggtc agcgagggca tggccctgca gctgggctgc    540

ctggagctca ggcggttctt caaggatatg ccccacaatg cacttgacaa gaagtccaac    600

ttcgagctcc tagaaaagga agtggggctg gacttgtttt tcccaaagca gatgcaggag    660

aacttaaagc ccaaacagtt ccggaagatg atccagcaga ccttccagca gtacgcctcg    720

ctcagggagg aggagtgcgt catgaagttc ttcaacactc tcgccggctt cgccaacatc    780

gaccaggaga cctaccgctg tgaactcatt caaggatgga acattactgt ggacctggtc    840

attggcccta aagggatccg ccagctgact agtcaggacg caaagcccac ctgcctggcc    900

gagttcaagc agatcaggtc catcaggtgc ctcccgctgg aggagggcca ggcagtactt    960

cagctgggca ttgaaggtgc cccccaggcc ttgtccatca aaacctcatc cctagcagag   1020

gctgagaaca tggctgacct catagacggc tactgccggc tgcagggtga gcaccaaggc   1080

tctctcatca tccatcctag gaaagatggt gagaagcgga acagcctgcc ccagatcccc   1140

atgctaaacc tggaggcccg gcggtcccac ctctcagaga gctgcagcat agagtcagac   1200

atctacgcag agattcccga cgaaaccctg cgaaggcccg gaggtccaca gtatggcatt   1260

gcccgtgaag atgtggtcct gaatcgtatt cttggggaag gcttttttgg ggaggtctat   1320

gaaggtgtct acacaaatca caaaggggag aaaatcaatg tagctgtcaa gacctgcaag   1380

aaagactgca ctctggacaa caaggagaag ttcatgagcg aggcagtgat catgaagaac   1440

ctcgaccacc cgcacatcgt gaagctgatc ggcatcattg aagaggagcc cacctggatc   1500

atcatggaat tgtatcccta tggggagctg ggccactacc tggagcggaa caagaactcc   1560

ctgaaggtgc tcaccctcgt gctgtactca ctgcagatat gcaaagccat ggcctacctg   1620

gagagcatca actgcgtgca cagggacatt gctgtccgga acatcctggt ggcctcccct   1680

gagtgtgtga agctggggga ctttggtctt tcccggtaca ttgaggacga ggactattac   1740

aaagcctctg tgactcgtct ccccatcaaa tggatgtccc cagagtccat taacttccga   1800

cgcttcacga cagccagtga cgtctggatg ttcgccgtgt gcatgtggga gatcctgagc   1860

tttgggaagc agcccttctt ctggctggag aacaaggatg tcatcggggt gctggagaaa   1920

ggagaccggc tgcccaagcc tgatctctgt ccaccggtcc tttataccct catgacccgc   1980

tgctgggact acgaccccag tgaccggccc cgcttcaccg agctggtgtg cagcctcagt   2040

gacgtttatc agatggagaa ggacattgcc atggagcaag agaggaatgc tcgctaccga   2100

acccccaaaa tcttggagcc cacagccttc caggaacccc cacccaagcc cagccgacct   2160

aagtacagac cccctccgca aaccaacctc ctggctccaa agctgcagtt ccaggttcct   2220

gagggtctgt gtgccagctc tcctacgctc accagcccta tggagtatcc atctcccgtt   2280

aactcactgc acaccccacc tctccaccgg cacaatgtct tcaaacgcca cagcatgcgg   2340

gaggaggact tcatccaacc cagcagccga gaagaggccc agcagctgtg ggaggctgaa   2400

aaggtcaaaa tgcggcaaat cctggacaaa cagcagaagc agatggtgga ggactaccag   2460

tggctcaggc aggaggagaa gtccctggac cccatggttt atatgaatga taagtcccca   2520

ttgacgccag agaaggaggt cggctacctg gagttcacag ggcccccaca gaagcccccg   2580

aggctgggcg cacagtccat ccagcccaca gctaacctgg accggaccga tgacctggtg   2640

tacctcaatg tcatggagct ggtgcgggcc gtgctggagc tcaagaatga gctctgtcag   2700

ctgccccccg agggctacgt ggtggtggtg aagaatgtgg ggctgaccct gcggaagctc   2760

atcgggagcg tggatgatct cctgccttcc ttgccgtcat cttcacggac agagatcgag   2820

ggcacccaga aactgctcaa caaagacctg gcagagctca tcaacaagat gcggctggcg   2880

cagcagaacg ccgtgacctc cctgagtgag gagtgcaaga ggcagatgct gacggcttca   2940

cacaccctgg ctgtggacgc caagaacctg ctcgacgctg tggaccaggc caaggttctg   3000

gccaatctgg cccacccacc tgcagagtga                                    3030


<210>  5
<211>  7841
<212>  DNA
<213>  Artificial

<220>
<223>  expression cassette of the AAV transfer vector encoding 
       codon-optimized mouse PYK2 (AAV-CaMKII-EGFP-T2A-mPTK2B)

<400>  5
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc     60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca    120

actccatcac taggggttcc tgcggccaat tcagtcgata actataacgg tcctaaggta    180

gcgatttaaa tacgcgctct cttaaggtag ccccgggacg cgtcaattga gcgatgatca    240

cttgtggact aagtttgttc gcatcccctt ctccaacccc ctcagtacat caccctgggg    300

gaacagggtc cacttgctcc tgggcccaca cagtcctgca gtattgtgta tataaggcca    360

gggcaaagag gagcaggttt taaagtgaaa ggcaggcagg tgttggggag gcagttaccg    420

gggcaacggg aacagggcgt ttcggaggtg gttgccatgg ggacctggat gctgacgaag    480

gctcgcgagg ctgtgagcag ccacagtgcc ctgctcagaa gccccaagct cgtcagtcaa    540

gccggttctc cgtttgcact caggagcacg ggcaggcgag tggcccctag ttctgggggc    600

agcgctagcg tttaaactta agcttggtac cggccgctgc ggccctcgag caagctggct    660

agttaagcta tcaacaagtt tgtataaaaa agcaggcttt aaaggaacca attcagtcga    720

cgctagctcg ccaccatggt gagcaagggc gaggagctgt tcaccggggt ggtgcccatc    780

ctggtcgagc tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag    840

ggcgatgcca cctacggcaa gctgaccctg aagttcatct gcaccaccgg caagctgccc    900

gtgccctggc ccaccctcgt gaccaccctg acctacggcg tgcagtgctt cagccgctac    960

cccgaccaca tgaagcagca cgacttcttc aagtccgcca tgcccgaagg ctacgtccag   1020

gagcgcacca tcttcttcaa ggacgacggc aactacaaga cccgcgccga ggtgaagttc   1080

gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc   1140

aacatcctgg ggcacaagct ggagtacaac tacaacagcc acaacgtcta tatcatggcc   1200

gacaagcaga agaacggcat caaggtgaac ttcaagatcc gccacaacat cgaggacggc   1260

agcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg ccccgtgctg   1320

ctgcccgaca accactacct gagcacccag tccgccctga gcaaagaccc caacgagaag   1380

cgcgatcaca tggtcctgct ggagttcgtg accgccgccg ggatcactct cggcatggac   1440

gagctgtaca agggatccgg cagtggagag ggcagaggaa gtctgctaac atgcggtgac   1500

gtcgaggaga atcctggccc aagatctatg tccggggtgt ctgagccctt gagccgtgta   1560

aaagtgggca ctttacgccg gcctgagggc cccccagagc ccatggtggt ggtaccagtg   1620

gatgtggaga aggaagacgt gcgcatcctc aaggtctgct tctacagcaa cagcttcaac   1680

ccagggaaga acttcaagct tgtcaaatgc acagtgcaga cagagatcca ggagatcatc   1740

acctccatcc tcctgagtgg gcgaataggg cccaacatcc agctggctga atgctatggg   1800

ctgaggctga agcacatgaa gtcagacgag atccactggc tgcacccaca gatgaccgtg   1860

ggcgaagtgc aggacaagta tgaatgtcta cacgtggaag ctgagtggag gtatgacctt   1920

caaatccgct acttgccgga agacttcatg gagagcctga aagaagacag gaccacattg   1980

ctgtactttt atcaacagct ccggaatgac tacatgcaac gctacgccag caaggtcagt   2040

gaaggcatgg ctctgcagct gggctgtctg gagctcagga gattcttcaa ggacatgccc   2100

cacaatgcac tggacaaaaa gtccaacttt gaactcctgg aaaaagaagt cggtctggac   2160

ctgtttttcc caaagcagat gcaggaaaac ttaaagccca agcagttccg gaagatgatc   2220

cagcagacct tccagcagta tgcatcactc cgggaggaag agtgtgtcat gaaattcttc   2280

aataccctag cgggctttgc caacattgac caggagacct accgctgcga actcattcaa   2340

ggatggaaca ttactgtgga cctggtcatc ggccctaaag gcatccgtca gctgacaagt   2400

caagatacaa agcccacctg cctggccgag tttaagcaga tcagatccat caggtgcctc   2460

ccattggaag agacccaggc agtcctgcag ctgggcatcg agggtgcccc ccagtccttg   2520

tctatcaaaa cgtcgtccct ggcagaggct gagaacatgg ctgatctcat agatggctac   2580

tgcaggctgc aaggagaaca taagggctct ctcatcatgc atgccaagaa agatggtgag   2640

aagaggaaca gcctgcctca gatccccaca ctaaacctgg aggctcggcg gtcgcacctc   2700

tcagaaagct gcagcataga gtcagacatc tatgcggaga ttcccgatga gaccctgcga   2760

agaccaggag gtccacagta cggtgttgcc cgtgaagaag tagttcttaa ccgcattctg   2820

ggtgaaggct tctttgggga ggtctatgaa ggtgtctaca cgaaccacaa aggggaaaaa   2880

attaatgtgg ccgtcaagac ctgtaagaaa gactgtaccc aggacaacaa ggagaagttc   2940

atgagtgagg cagtgatcat gaagaatctt gaccaccctc acatcgtgaa gctgattggc   3000

atcattgaag aggaacccac ctggattatc atggaactgt atccttatgg ggagctggga   3060

cactacctgg aacgaaataa aaactccctg aaggtaccca ctctggtcct gtacacccta   3120

cagatatgca aagccatggc ctatctggag agcatcaact gtgtgcacag ggatattgct   3180

gtccggaaca tcctggtggc ctctcctgag tgtgtgaagc tgggggactt tgggctctcc   3240

cggtacattg aggacgaaga ctattacaaa gcctctgtga cacgtctacc catcaaatgg   3300

atgtcccccg agtccatcaa cttccgccgc ttcacaaccg ccagtgatgt ctggatgttt   3360

gctgtatgca tgtgggagat cctcagcttt gggaagcagc ctttcttctg gctcgaaaat   3420

aaggatgtca tcggagtgct ggagaaaggg gacaggctgc ccaagcccga actctgtccg   3480

cctgtccttt acacactcat gactcgctgc tgggactacg accccagtga ccggccccgc   3540

ttcacggagc ttgtgtgcag cctcagtgac atttatcaga tggagaagga cattgccata   3600

gagcaagaaa ggaatgctcg ctaccgaccc cctaaaatat tggagcctac tacctttcag   3660

gaacccccac ccaagcccag ccggcccaag tacagacctc ctccacagac caacctgctg   3720

gctcctaagc tgcagttcca ggtccctgag ggtctgtgtg ccagctctcc tacgcttacc   3780

agccctatgg agtatccatc tccagttaac tcgctgcaca ccccacctct ccaccggcac   3840

aatgtcttca agcgccacag catgcgggag gaggacttca tccggcccag tagccgagaa   3900

gaggcccagc agctctggga ggcagagaag atcaagatga agcaggtcct agaaagacag   3960

cagaagcaga tggtggaaga ttcccagtgg ctgaggcgag aggaaagatg cttggaccct   4020

atggtttata tgaatgacaa gtccccactg actccagaga aggaggccgg ctacacggag   4080

ttcacagggc ccccacagaa accacctcgg ctcggtgcac agtccattca gcccacagcc   4140

aacctggaca ggaccgatga cctcgtgtac cacaatgtca tgaccctggt ggaggctgtg   4200

ctggaactca agaacaagct tggccagttg ccccctgagg actatgtggt ggtggtgaag   4260

aacgtggggc tgaacctgcg gaagctcatc ggcagtgtgg acgatctctt gccctccttg   4320

ccggcatctt cgaggacaga gattgaaggg acccagaaac tgctcaacaa agacctggca   4380

gagctcatca acaagatgaa gttggctcag cagaacgccg tgacgtccct gagtgaggac   4440

tgcaagcggc agatgctcac agcgtcccat accctggctg tggatgccaa gaacctgctg   4500

gatgctgtgg accaagccaa ggttgtggct aatctggccc acccgcctgc agagtgagcg   4560

gccgcctcga gtctagaccc agctttcttg tataaagtgg ttgatctaga gggcccgtaa   4620

ctagttgaca tatgaccggt tagtaatgag tttatccagc acagtggcgg ccgctcgagt   4680

ctagagggcc cttcgaaggt aagcctatcc ctaaccctct cctcggtctc gattctacgc   4740

gtaccggtca tcatcaccat caccattgag tttaaacccg ctgatcagcc tcgactgtgc   4800

cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag   4860

gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta   4920

ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag   4980

acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca   5040

gatcctctct taaggtagca tcgagattta aattagggat aacagggtaa tggcgcgggc   5100

cgcaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg   5160

aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg   5220

agcgagcgcg cagctgcctg caggggcgcc tgatgcggta ttttctcctt acgcatctgt   5280

gcggtatttc acaccgcata cgtcaaagca accatagtac gcgccctgta gcggcgcatt   5340

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc   5400

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca   5460

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc   5520

caaaaaactt gatttgggtg atggttcacg tagtgggcca tcgccctgat agacggtttt   5580

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac   5640

aacactcaac cctatctcgg gctattcttt tgatttataa gggattttgc cgatttcggc   5700

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt   5760

aacgtttaca attttatggt gcactctcag tacaatctgc tctgatgccg catagttaag   5820

ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc   5880

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc   5940

gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa   6000

tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg   6060

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata   6120

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg   6180

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac   6240

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact   6300

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat   6360

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga   6420

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac   6480

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat   6540

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac   6600

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct   6660

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac   6720

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga   6780

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg   6840

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact   6900

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac   6960

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta   7020

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt   7080

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga   7140

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc   7200

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt   7260

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc   7320

gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc   7380

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg   7440

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg   7500

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga   7560

actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc   7620

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg   7680

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg   7740

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt   7800

tttacggttc ctggcctttt gctggccttt tgctcacatg t                       7841


<210>  6
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Pyk2 forward primer

<400>  6
gagagtgctg ggtactccag actcagatag                                      30


<210>  7
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Pyk2 reverse primer

<400>  7
ttcaggaaca ccagagaact agggtgg                                         27


