                         SEQUENCE LISTING

<110>  Medicago Inc.
 
<120>  Norovirus Fusion Proteins and VLPs Comprising Norovirus Fusion 
       Proteins

<130>  V810810WO

<150>  US 62/475,660
<151>  2017-03-23

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  530
<212>  PRT
<213>  Norovirus GI.1/Norwalk/1968/US

<400>  1

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Gln Lys Thr Arg Pro Phe Thr Leu Pro Asn Leu Pro Leu Ser Ser 
225                 230                 235                 240 


Leu Ser Asn Ser Arg Ala Pro Leu Pro Ile Ser Ser Met Gly Ile Ser 
                245                 250                 255     


Pro Asp Asn Val Gln Ser Val Gln Phe Gln Asn Gly Arg Cys Thr Leu 
            260                 265                 270         


Asp Gly Arg Leu Val Gly Thr Thr Pro Val Ser Leu Ser His Val Ala 
        275                 280                 285             


Lys Ile Arg Gly Thr Ser Asn Gly Thr Val Ile Asn Leu Thr Glu Leu 
    290                 295                 300                 


Asp Gly Thr Pro Phe His Pro Phe Glu Gly Pro Ala Pro Ile Gly Phe 
305                 310                 315                 320 


Pro Asp Leu Gly Gly Cys Asp Trp His Ile Asn Met Thr Gln Phe Gly 
                325                 330                 335     


His Ser Ser Gln Thr Gln Tyr Asp Val Asp Thr Thr Pro Asp Thr Phe 
            340                 345                 350         


Val Pro His Leu Gly Ser Ile Gln Ala Asn Gly Ile Gly Ser Gly Asn 
        355                 360                 365             


Tyr Val Gly Val Leu Ser Trp Ile Ser Pro Pro Ser His Pro Ser Gly 
    370                 375                 380                 


Ser Gln Val Asp Leu Trp Lys Ile Pro Asn Tyr Gly Ser Ser Ile Thr 
385                 390                 395                 400 


Glu Ala Thr His Leu Ala Pro Ser Val Tyr Pro Pro Gly Phe Gly Glu 
                405                 410                 415     


Val Leu Val Phe Phe Met Ser Lys Met Pro Gly Pro Gly Ala Tyr Asn 
            420                 425                 430         


Leu Pro Cys Leu Leu Pro Gln Glu Tyr Ile Ser His Leu Ala Ser Glu 
        435                 440                 445             


Gln Ala Pro Thr Val Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro 
    450                 455                 460                 


Asp Thr Gly Arg Asn Leu Gly Glu Phe Lys Ala Tyr Pro Asp Gly Phe 
465                 470                 475                 480 


Leu Thr Cys Val Pro Asn Gly Ala Ser Ser Gly Pro Gln Gln Leu Pro 
                485                 490                 495     


Ile Asn Gly Val Phe Val Phe Val Ser Trp Val Ser Arg Phe Tyr Gln 
            500                 505                 510         


Leu Lys Pro Val Gly Thr Ala Ser Ser Ala Arg Gly Arg Leu Gly Leu 
        515                 520                 525             


Arg Arg 
    530 


<210>  2
<211>  546
<212>  PRT
<213>  Norovirus GI.2/Leuven/2003/Bel

<400>  2

Met Met Met Ala Ser Lys Asp Ala Pro Gln Ser Ala Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Thr Ala Asp Pro Leu Pro 
            20                  25                  30          


Met Glu Pro Val Ala Gly Pro Thr Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Val Asn Asn Phe Val Gln Ser Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Leu 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Ser Ala Gly Lys Ile Ile Val Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Thr Ser Ser Ser Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Glu Pro Ile Glu Met 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Tyr His Thr Asn Asp Asn Gln 
                165                 170                 175     


Pro Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly 
            180                 185                 190         


Gly Gly Ser Gly Asn Ser Asp Ser Phe Val Val Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Ala Pro Ser Ser Asp Phe Ser Phe Leu Phe Leu Val Pro Pro Thr 
    210                 215                 220                 


Ile Glu Gln Lys Thr Arg Ala Phe Thr Val Pro Asn Ile Pro Leu Gln 
225                 230                 235                 240 


Thr Leu Ser Asn Ser Arg Phe Pro Ser Leu Ile Gln Gly Met Ile Leu 
                245                 250                 255     


Ser Pro Asp Ala Ser Gln Val Val Gln Phe Gln Asn Gly Arg Cys Leu 
            260                 265                 270         


Ile Asp Gly Gln Leu Leu Gly Thr Thr Pro Ala Thr Ser Gly Gln Leu 
        275                 280                 285             


Phe Arg Val Arg Gly Lys Ile Asn Gln Gly Ala Arg Thr Leu Asn Leu 
    290                 295                 300                 


Thr Glu Val Asp Gly Lys Pro Phe Met Ala Phe Asp Ser Pro Ala Pro 
305                 310                 315                 320 


Val Gly Phe Pro Asp Phe Gly Lys Cys Asp Trp His Met Arg Ile Ser 
                325                 330                 335     


Lys Thr Pro Asn Asn Thr Ser Ser Gly Asp Pro Met Arg Ser Val Asp 
            340                 345                 350         


Val Gln Thr Asp Val Gln Gly Phe Val Pro His Leu Gly Ser Ile Gln 
        355                 360                 365             


Phe Asp Glu Val Phe Asn His Pro Thr Gly Asp Tyr Ile Gly Thr Ile 
    370                 375                 380                 


Glu Trp Ile Ser Gln Pro Ser Thr Pro Pro Gly Thr Asp Ile Asn Leu 
385                 390                 395                 400 


Trp Glu Ile Pro Asp Tyr Gly Ser Ser Leu Ser Gln Ala Ala Asn Leu 
                405                 410                 415     


Ala Pro Pro Val Phe Pro Pro Gly Phe Gly Glu Ala Leu Val Tyr Phe 
            420                 425                 430         


Val Ser Ala Phe Pro Gly Pro Asn Asn Arg Ser Ala Pro Asn Asp Val 
        435                 440                 445             


Pro Cys Leu Leu Pro Gln Glu Tyr Val Thr His Phe Val Ser Glu Gln 
    450                 455                 460                 


Ala Pro Thr Met Gly Asp Ala Ala Leu Leu His Tyr Val Asp Pro Asp 
465                 470                 475                 480 


Thr Asn Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu 
                485                 490                 495     


Thr Cys Val Pro Asn Gly Val Gly Ala Gly Pro Gln Gln Leu Pro Leu 
            500                 505                 510         


Asn Gly Val Phe Leu Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu 
        515                 520                 525             


Lys Pro Val Gly Thr Ala Ser Thr Ala Arg Gly Arg Leu Gly Val Arg 
    530                 535                 540                 


Arg Ile 
545     


<210>  3
<211>  543
<212>  PRT
<213>  Norovirus GI.3/S29/2008/Lilla Edet/Sweden

<400>  3

Met Met Met Ala Ser Lys Asp Ala Pro Thr Asn Met Asp Gly Thr Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Ser Thr Ala Glu Pro Ile Ser 
            20                  25                  30          


Met Glu Pro Val Ala Gly Ala Ala Thr Ala Ala Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Met Ser Asn Tyr Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ser His Leu 
                85                  90                  95      


Ala Gln Met Tyr Asn Gly Trp Val Gly Asn Met Lys Val Arg Val Leu 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Ile Ser Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Ala Ala Gln Asn Val Ser Ile Ala Gln Ala Thr Met 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Val Leu Glu Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Ser Thr 
                165                 170                 175     


Pro Thr Met Arg Leu Ile Cys Met Leu Tyr Thr Pro Leu Arg Ala Ser 
            180                 185                 190         


Gly Ser Ser Ser Gly Thr Asp Pro Phe Val Ile Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Asn 
    210                 215                 220                 


Val Glu Gln Lys Thr Lys Pro Phe Ser Val Pro Asn Leu Pro Leu Asn 
225                 230                 235                 240 


Val Leu Ser Asn Ser Arg Val Pro Ser Leu Ile Lys Ser Met Met Val 
                245                 250                 255     


Ser Gln Asp His Gly Gln Met Val Gln Phe Gln Asn Gly Arg Val Thr 
            260                 265                 270         


Leu Asp Gly Gln Leu Gln Gly Thr Thr Pro Thr Ser Ala Ser Gln Leu 
        275                 280                 285             


Cys Lys Ile Arg Gly Thr Val Tyr His Ala Thr Gly Gly Gln Gly Leu 
    290                 295                 300                 


Asn Leu Thr Glu Ile Asp Gly Thr Pro Tyr His Ala Phe Glu Ser Pro 
305                 310                 315                 320 


Ala Pro Ile Gly Phe Pro Asp Leu Gly Glu Cys Asp Trp His Ile Asn 
                325                 330                 335     


Ala Ser Pro Ala Asn Ala Phe Thr Asp Gly Ser Ile Ile His Arg Ile 
            340                 345                 350         


Asp Val Ala Gln Asp Ser Thr Phe Ala Pro His Leu Gly Thr Ile His 
        355                 360                 365             


Tyr Thr Asn Ala Asp Tyr Asn Ala Asn Val Gly Leu Ile Cys Ser Leu 
    370                 375                 380                 


Glu Trp Leu Ser Pro Pro Ser Gly Gly Ala Pro Lys Val Asn Pro Trp 
385                 390                 395                 400 


Ala Ile Pro Arg Tyr Gly Ser Thr Leu Thr Glu Ala Ala Gln Leu Ala 
                405                 410                 415     


Pro Pro Ile Tyr Pro Pro Gly Phe Gly Glu Ala Ile Val Phe Phe Met 
            420                 425                 430         


Ser Asp Phe Pro Ile Ala Asn Gly Ser Asp Gly Leu Ser Val Pro Cys 
        435                 440                 445             


Thr Ile Pro Gln Glu Phe Val Thr His Phe Val Asn Glu Gln Ala Pro 
    450                 455                 460                 


Thr Arg Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr His 
465                 470                 475                 480 


Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Glu Gly Phe Met Thr Cys 
                485                 490                 495     


Val Pro Asn Ser Ser Gly Ser Gly Pro Gln Thr Leu Pro Ile Asn Gly 
            500                 505                 510         


Val Phe Thr Phe Ile Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro 
        515                 520                 525             


Val Gly Thr Thr Gly Pro Val Arg Arg Leu Gly Ile Arg Arg Ser 
    530                 535                 540             


<210>  4
<211>  540
<212>  PRT
<213>  Norovirus GII.4/Sydney/NSW0514/2012/AU

<400>  4

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Val Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Pro Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asp Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly Arg Val Gln Phe Glu 
        355                 360                 365             


Thr Asp Thr Asp Arg Asp Phe Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Gly Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Val 
    530                 535                 540 


<210>  5
<211>  547
<212>  PRT
<213>  Norovirus GII.6/Ohio/490/12

<400>  5

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Ala Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ser Ile Ala Ala Pro Val Val Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Glu Asn Phe Val Gln Ala Pro Gln Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Met Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ser His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Met Gln Val Gln Val Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Val Glu Asn Ile Asn Ala Ala Gln Ile Thr Met Cys Pro His Val 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Ile Arg Asn Arg Phe Phe His Tyr Asn Gln Glu Asn Thr Ser Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Ser Gly Glu 
            180                 185                 190         


Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ala Pro Asp 
        195                 200                 205             


Phe Glu Phe Thr Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr Lys 
    210                 215                 220                 


Pro Phe Ser Leu Pro Ile Leu Thr Leu Gly Glu Leu Ser Asn Ser Arg 
225                 230                 235                 240 


Phe Pro Ala Pro Ile Asp Met Leu Tyr Thr Asp Pro Asn Glu Gly Ile 
                245                 250                 255     


Val Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Asp Gly Thr Leu Gln 
            260                 265                 270         


Gly Thr Thr Gln Leu Val Pro Thr Gln Ile Cys Ala Phe Arg Gly Thr 
        275                 280                 285             


Leu Ile Gly Gln Thr Ser Arg Ser Pro Asp Ser Thr Asp Ser Ala Pro 
    290                 295                 300                 


Arg Arg Arg Asp His Pro Leu His Val Gln Leu Lys Asn Leu Asp Gly 
305                 310                 315                 320 


Thr Gln Tyr Asp Pro Thr Asp Glu Val Pro Ala Val Leu Gly Ala Ile 
                325                 330                 335     


Asp Phe Lys Gly Thr Val Phe Gly Val Ala Ser Gln Arg Asp Val Ser 
            340                 345                 350         


Gly Gln Gln Val Gly Ala Thr Arg Ala His Glu Val His Ile Asn Thr 
        355                 360                 365             


Thr Asp Pro Arg Tyr Thr Pro Lys Leu Gly Ser Ile Leu Met Tyr Ser 
    370                 375                 380                 


Glu Ser Asp Asp Phe Val Thr Gly Gln Pro Val Arg Phe Thr Pro Ile 
385                 390                 395                 400 


Gly Met Gly Asp Asn Asp Trp His Gln Trp Glu Leu Pro Asp Tyr Pro 
                405                 410                 415     


Gly His Leu Thr Leu Asn Met Asn Leu Ala Pro Ala Val Ala Pro Ala 
            420                 425                 430         


Phe Pro Gly Glu Arg Ile Leu Phe Phe Arg Ser Ile Val Pro Ser Ala 
        435                 440                 445             


Gly Gly Tyr Gly Ser Gly Gln Ile Asp Cys Leu Ile Pro Gln Glu Trp 
    450                 455                 460                 


Val Gln His Phe Tyr Gln Glu Ala Ala Pro Ser Gln Ser Ala Val Ala 
465                 470                 475                 480 


Leu Ile Arg Tyr Val Asn Pro Asp Thr Gly Arg Asn Ile Phe Glu Ala 
                485                 490                 495     


Lys Leu His Arg Glu Gly Phe Ile Thr Val Ala Asn Ser Gly Asn Asn 
            500                 505                 510         


Pro Ile Val Val Pro Pro Asn Gly Tyr Phe Arg Phe Glu Ala Trp Val 
        515                 520                 525             


Asn Gln Phe Tyr Thr Leu Thr Pro Met Gly Thr Gly Gln Gly Arg Arg 
    530                 535                 540                 


Arg Asp Gln 
545         


<210>  6
<211>  542
<212>  PRT
<213>  Norovirus GII.13/VA173/2010/USA

<400>  6

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Ser Leu Val Pro Glu Ala Ile Asn Glu Thr Met Pro Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Val Ala Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Thr Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Ile Pro Pro Asn Phe 
        115                 120                 125             


Pro Val Asp Met Ile Ser Pro Ala Gln Ile Thr Met Leu Pro His Leu 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Ile Met Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Val Phe Tyr His Phe Asn Asn Gln Pro Gln Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             


Asp Phe Glu Phe Ile Tyr Leu Val Pro Pro Ser Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Ser Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Ser Ile Glu Gln Leu Tyr Thr Ala Pro Asn Glu Asn 
                245                 250                 255     


Asn Val Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Ser Ser Ala Val Cys Ser Tyr Arg Gly 
        275                 280                 285             


Arg Thr Val Ala Asn Ser Gly Asp Asn Trp Asp Gln Asn Val Leu Gln 
    290                 295                 300                 


Leu Thr Tyr Pro Ser Gly Ala Ser Tyr Asp Pro Thr Asp Glu Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Thr Gln Asp Phe Ser Gly Ile Leu Tyr Gly Val Leu 
                325                 330                 335     


Thr Gln Asp Asn Val Arg Glu Asn Thr Gly Glu Ala Lys Asn Ala Lys 
            340                 345                 350         


Gly Val Tyr Ile Ser Thr Thr Ser Gly Lys Phe Thr Pro Lys Ile Gly 
        355                 360                 365             


Ser Ile Gly Leu His Ser Ile Thr Glu Asp Val Arg Pro Asn Gln Gln 
    370                 375                 380                 


Ser Arg Phe Thr Pro Val Gly Val Ala Gln Asn Glu Asn Thr Pro Phe 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro His Tyr Ala Gly Ala Leu Ala Leu Asn Thr 
                405                 410                 415     


Asn Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Arg Val Pro Cys Val Gln Gly Leu Gln Gly Gln Asp 
        435                 440                 445             


Ala Phe Ile Asp Cys Leu Leu Pro Gln Glu Trp Val Asn His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ser Gln Ala Asp Val Ala Leu Ile Arg Tyr Val 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Thr Leu Phe Glu Ala Lys Leu His Arg Ser 
                485                 490                 495     


Gly Phe Ile Thr Val Ser His Thr Gly Ala Tyr Pro Leu Val Val Pro 
            500                 505                 510         


Pro Asn Gly His Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser 
        515                 520                 525             


Leu Ala Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Val Gln 
    530                 535                 540         


<210>  7
<211>  538
<212>  PRT
<213>  Norovirus GII.17/Kawasaki323/2014/JP

<400>  7

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Gly Asn Asn Glu Thr Leu Pro Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Ile Ala Ala Pro Val Thr Gly Gln Asn Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Thr Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Val Glu Phe Leu Ser Pro Ala Gln Ile Thr Met Leu Pro His Leu 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Ile Met Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Thr Phe Phe His Tyr Asn Asn Gln Pro Asn Ser Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             


Asp Phe Glu Phe Thr Tyr Leu Val Pro Pro Ser Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Ser Leu Pro Ile Leu Thr Leu Ser Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Ser Leu Phe Thr Ala Gln Asn Asn Val 
                245                 250                 255     


Leu Gln Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Pro Ser Gly Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Arg Val Thr Ala Glu Thr Asp His Arg Asp Lys Trp His Met Gln Leu 
    290                 295                 300                 


Gln Asn Leu Asn Gly Thr Thr Tyr Asp Pro Thr Asp Asp Val Pro Ala 
305                 310                 315                 320 


Pro Leu Gly Thr Pro Asp Phe Lys Gly Val Val Phe Gly Val Ala Ser 
                325                 330                 335     


Gln Arg Asn Val Gly Asn Asp Ala Pro Gly Ser Thr Arg Ala His Glu 
            340                 345                 350         


Ala Val Ile Ser Thr Tyr Ser Pro Gln Phe Val Pro Lys Leu Gly Ser 
        355                 360                 365             


Val Asn Phe Arg Ser Asn Asp Asn Asp Phe Gln Leu Gln Pro Thr Lys 
    370                 375                 380                 


Phe Thr Pro Val Gly Ile Asn Asp Asp Gly Asp His Pro Phe Arg Gln 
385                 390                 395                 400 


Trp Glu Leu Pro Asp Tyr Ser Gly Leu Leu Thr Leu Asn Met Asn Leu 
                405                 410                 415     


Ala Pro Pro Val Ala Pro Asn Phe Pro Gly Glu Gln Leu Leu Phe Phe 
            420                 425                 430         


Arg Ser Phe Val Pro Cys Ser Gly Gly Tyr Asn Gln Gly Ile Val Asp 
        435                 440                 445             


Cys Leu Ile Pro Gln Glu Trp Ile Gln His Phe Tyr Gln Glu Ser Ala 
    450                 455                 460                 


Pro Ser Gln Ser Asp Val Ala Leu Ile Arg Tyr Val Asn Pro Asp Thr 
465                 470                 475                 480 


Gly Arg Thr Leu Phe Glu Ala Lys Leu His Arg Ser Gly Tyr Ile Thr 
                485                 490                 495     


Val Ala His Ser Gly Asp Tyr Pro Leu Val Val Pro Ala Asn Gly Tyr 
            500                 505                 510         


Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Met 
        515                 520                 525             


Gly Thr Gly Asn Gly Arg Arg Arg Ala Gln 
    530                 535             


<210>  8
<211>  539
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of VP1 US96: 
       GII.4/Dresden174/1997/DE_AY741811

<400>  8

Met Lys Met Ala Ser Asn Asp Ala Asn Pro Ser Asp Gly Ser Thr Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Val Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Ser Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Lys Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Tyr Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Ala Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Ala Gly Ser His Asp Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Met Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Glu Asp Gly Ser Thr Arg Ala His Lys Ala Thr Val Ser 
            340                 345                 350         


Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val Gln Tyr Thr 
        355                 360                 365             


Thr Asp Thr Asn Asn Asp Phe Gln Thr Gly Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Asn Asn His Gln Asn Glu Pro Gln 
385                 390                 395                 400 


Gln Trp Val Leu Pro Asn Tyr Ser Gly Arg Thr Gly His Asn Val His 
                405                 410                 415     


Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu Phe 
            420                 425                 430         


Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asn Leu 
        435                 440                 445             


Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu Ala 
    450                 455                 460                 


Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro Asp 
465                 470                 475                 480 


Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr Val 
                485                 490                 495     


Thr Val Ala His Thr Gly Pro His Asp Leu Val Ile Pro Pro Asn Gly 
            500                 505                 510         


Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala Pro 
        515                 520                 525             


Met Gly Asn Gly Ala Gly Arg Arg Arg Ala Leu 
    530                 535                 


<210>  9
<211>  540
<212>  PRT
<213>  Norovirus GII.4/Dresden174/1997/DE

<400>  9

Met Lys Met Ala Ser Asn Asp Ala Asn Pro Ser Asp Gly Ser Thr Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Leu Asn Asp Pro Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Glu Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Gly Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Ala Gly Thr His Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Arg Ile Gln Gly Met Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Gly Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Ser 
            340                 345                 350         


Thr Gly Asp Val His Phe Thr Pro Lys Leu Gly Ser Ile Gln Phe Asn 
        355                 360                 365             


Thr Asp Thr Asn Asn Asp Phe Glu Thr Gly Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Val Gln Asp Gly Asn Gly Thr His Gln Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Thr Gly His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asn 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 540 


<210>  10
<211>  540
<212>  PRT
<213>  Norovirus GII.4/Hunter-NSW504D/2004/AU

<400>  10

Met Lys Met Ala Ser Asn Asp Ala Thr Pro Ser Asp Gly Ser Thr Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Val Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Leu Tyr His Tyr Asn Gln Ser Asn Asp Pro Thr Ile 
                165                 170                 175     


Arg Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Ile Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Ala Gly Thr Gln Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asn Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Arg Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Arg Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Ser 
            340                 345                 350         


Thr Gly Ser Val His Phe Thr Pro Lys Leu Gly Ser Val Gln Phe Ser 
        355                 360                 365             


Thr Asp Thr Ser Asn Asp Phe Glu Thr Gly Gln Asn Thr Arg Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Val Gln Asp Gly Ser Thr Thr His Gln Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Asp Tyr Ser Gly Arg Asp Ser His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asn 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ser Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Ala Gly Arg Arg Arg Ala Leu 
    530                 535                 540 


<210>  11
<211>  540
<212>  PRT
<213>  Norovirus GII.4/Shellharbour-NSW696T/2006/AU

<400>  11

Met Lys Met Ala Ser Asn Asp Ala Asn Pro Ser Asp Gly Ser Ala Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Ser Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Glu Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Thr Val Pro Ile Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Gly Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Ala Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Leu Lys Trp Asn Lys Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Lys Gly Asp Gly Ser Thr Arg Gly His Lys Ala Thr Ile Tyr 
            340                 345                 350         


Thr Gly Ser Ala Pro Phe Thr Pro Lys Leu Gly Ser Val Gln Phe Ser 
        355                 360                 365             


Thr Asp Thr Glu Asn Asp Phe Glu Thr His Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Thr Gln Asp Gly Ser Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Val His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 540 


<210>  12
<211>  540
<212>  PRT
<213>  Norovirus GII.4/Orange-NSW001P/2008/AU

<400>  12

Met Lys Met Ala Ser Ser Asp Ala Asn Pro Ser Asp Gly Ser Thr Ala 
1               5                   10                  15      


Asn Leu Val Pro Glu Val Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ala Ile Ala Ala Pro Val Ala Gly Gln Gln Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ala Pro Gly Glu Ile Leu Trp Ser Ala Pro 
65                  70                  75                  80  


Leu Gly Pro Asp Met Asn Pro Tyr Leu Ser His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Ile Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Thr Glu Gly Leu Ser Pro Ser Gln Val Thr Met Phe Pro His Ile 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Tyr His Tyr Asn Gln Ser Asn Asp Pro Thr Ile 
                165                 170                 175     


Lys Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ala Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Ile Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Ile Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Ala Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Ser Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Asp Phe Ser Pro Lys Leu Gly Arg Val Gln Phe Ala 
        355                 360                 365             


Thr Asp Thr Asp Asn Asp Phe Asp Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Asn Thr Ala His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Leu 
    530                 535                 540 


<210>  13
<211>  1593
<212>  PRT
<213>  Norovirus GI.1/Norwalk/1968/US

<400>  13

Ala Thr Gly Ala Thr Gly Ala Thr Gly Gly Cys Gly Thr Cys Thr Ala 
1               5                   10                  15      


Ala Gly Gly Ala Cys Gly Cys Thr Ala Cys Ala Thr Cys Ala Ala Gly 
            20                  25                  30          


Cys Gly Thr Gly Gly Ala Thr Gly Gly Cys Gly Cys Thr Ala Gly Thr 
        35                  40                  45              


Gly Gly Cys Gly Cys Thr Gly Gly Thr Cys Ala Gly Thr Thr Gly Gly 
    50                  55                  60                  


Thr Ala Cys Cys Gly Gly Ala Gly Gly Thr Thr Ala Ala Thr Gly Cys 
65                  70                  75                  80  


Thr Thr Cys Thr Gly Ala Cys Cys Cys Thr Cys Thr Thr Gly Cys Ala 
                85                  90                  95      


Ala Thr Gly Gly Ala Thr Cys Cys Thr Gly Thr Ala Gly Cys Ala Gly 
            100                 105                 110         


Gly Thr Thr Cys Thr Thr Cys Gly Ala Cys Ala Gly Cys Ala Gly Thr 
        115                 120                 125             


Cys Gly Cys Gly Ala Cys Thr Gly Cys Thr Gly Gly Ala Cys Ala Ala 
    130                 135                 140                 


Gly Thr Thr Ala Ala Thr Cys Cys Thr Ala Thr Thr Gly Ala Thr Cys 
145                 150                 155                 160 


Cys Cys Thr Gly Gly Ala Thr Ala Ala Thr Thr Ala Ala Thr Ala Ala 
                165                 170                 175     


Thr Thr Thr Thr Gly Thr Gly Cys Ala Ala Gly Cys Cys Cys Cys Cys 
            180                 185                 190         


Cys Ala Ala Gly Gly Thr Gly Ala Ala Thr Thr Thr Ala Cys Thr Ala 
        195                 200                 205             


Thr Thr Thr Cys Cys Cys Cys Ala Ala Ala Thr Ala Ala Thr Ala Cys 
    210                 215                 220                 


Cys Cys Cys Cys Gly Gly Thr Gly Ala Thr Gly Thr Thr Thr Thr Gly 
225                 230                 235                 240 


Thr Thr Thr Gly Ala Thr Thr Thr Gly Ala Gly Thr Thr Thr Gly Gly 
                245                 250                 255     


Gly Thr Cys Cys Cys Cys Ala Thr Cys Thr Thr Ala Ala Thr Cys Cys 
            260                 265                 270         


Thr Thr Thr Cys Thr Thr Gly Cys Thr Cys Cys Ala Thr Cys Thr Ala 
        275                 280                 285             


Thr Cys Ala Cys Ala Ala Ala Thr Gly Thr Ala Thr Ala Ala Thr Gly 
    290                 295                 300                 


Gly Thr Thr Gly Gly Gly Thr Thr Gly Gly Thr Ala Ala Cys Ala Thr 
305                 310                 315                 320 


Gly Ala Gly Ala Gly Thr Cys Ala Gly Gly Ala Thr Thr Ala Thr Gly 
                325                 330                 335     


Cys Thr Ala Gly Cys Thr Gly Gly Thr Ala Ala Thr Gly Cys Cys Thr 
            340                 345                 350         


Thr Thr Ala Cys Thr Gly Cys Gly Gly Gly Gly Ala Ala Gly Ala Thr 
        355                 360                 365             


Ala Ala Thr Ala Gly Thr Thr Thr Cys Cys Thr Gly Cys Ala Thr Ala 
    370                 375                 380                 


Cys Cys Cys Cys Cys Thr Gly Gly Thr Thr Thr Thr Gly Gly Thr Thr 
385                 390                 395                 400 


Cys Ala Cys Ala Thr Ala Ala Thr Cys Thr Thr Ala Cys Thr Ala Thr 
                405                 410                 415     


Ala Gly Cys Ala Cys Ala Ala Gly Cys Ala Ala Cys Thr Cys Thr Cys 
            420                 425                 430         


Thr Thr Thr Cys Cys Ala Cys Ala Thr Gly Thr Gly Ala Thr Thr Gly 
        435                 440                 445             


Cys Thr Gly Ala Thr Gly Thr Thr Ala Gly Gly Ala Cys Thr Cys Thr 
    450                 455                 460                 


Ala Gly Ala Cys Cys Cys Cys Ala Thr Thr Gly Ala Gly Gly Thr Gly 
465                 470                 475                 480 


Cys Cys Thr Thr Thr Gly Gly Ala Ala Gly Ala Thr Gly Thr Thr Ala 
                485                 490                 495     


Gly Gly Ala Ala Thr Gly Thr Thr Cys Thr Cys Thr Thr Thr Cys Ala 
            500                 505                 510         


Thr Ala Ala Thr Ala Ala Thr Gly Ala Thr Ala Gly Ala Ala Ala Thr 
        515                 520                 525             


Cys Ala Ala Cys Ala Ala Ala Cys Cys Ala Thr Gly Cys Gly Cys Cys 
    530                 535                 540                 


Thr Thr Gly Thr Gly Thr Gly Cys Ala Thr Gly Cys Thr Gly Thr Ala 
545                 550                 555                 560 


Cys Ala Cys Cys Cys Cys Cys Cys Thr Cys Cys Gly Cys Ala Cys Thr 
                565                 570                 575     


Gly Gly Thr Gly Gly Thr Gly Gly Thr Ala Cys Thr Gly Gly Thr Gly 
            580                 585                 590         


Ala Thr Thr Cys Thr Thr Thr Thr Gly Thr Ala Gly Thr Thr Gly Cys 
        595                 600                 605             


Ala Gly Gly Gly Cys Gly Ala Gly Thr Thr Ala Thr Gly Ala Cys Thr 
    610                 615                 620                 


Thr Gly Cys Cys Cys Cys Ala Gly Thr Cys Cys Thr Gly Ala Thr Thr 
625                 630                 635                 640 


Thr Thr Ala Ala Thr Thr Thr Cys Thr Thr Gly Thr Thr Thr Thr Thr 
                645                 650                 655     


Ala Gly Thr Cys Cys Cys Thr Cys Cys Thr Ala Cys Gly Gly Thr Gly 
            660                 665                 670         


Gly Ala Gly Cys Ala Gly Ala Ala Ala Ala Cys Cys Ala Gly Gly Cys 
        675                 680                 685             


Cys Cys Thr Thr Cys Ala Cys Ala Cys Thr Cys Cys Cys Ala Ala Ala 
    690                 695                 700                 


Thr Cys Thr Gly Cys Cys Ala Thr Thr Gly Ala Gly Thr Thr Cys Thr 
705                 710                 715                 720 


Cys Thr Gly Thr Cys Thr Ala Ala Cys Thr Cys Ala Cys Gly Thr Gly 
                725                 730                 735     


Cys Cys Cys Cys Thr Cys Thr Cys Cys Cys Ala Ala Thr Cys Ala Gly 
            740                 745                 750         


Thr Ala Gly Thr Ala Thr Gly Gly Gly Cys Ala Thr Thr Thr Cys Cys 
        755                 760                 765             


Cys Cys Ala Gly Ala Cys Ala Ala Thr Gly Thr Cys Cys Ala Gly Ala 
    770                 775                 780                 


Gly Thr Gly Thr Gly Cys Ala Gly Thr Thr Cys Cys Ala Ala Ala Ala 
785                 790                 795                 800 


Thr Gly Gly Thr Cys Gly Gly Thr Gly Thr Ala Cys Thr Cys Thr Gly 
                805                 810                 815     


Gly Ala Thr Gly Gly Cys Cys Gly Cys Cys Thr Gly Gly Thr Thr Gly 
            820                 825                 830         


Gly Cys Ala Cys Cys Ala Cys Cys Cys Cys Ala Gly Thr Thr Thr Cys 
        835                 840                 845             


Ala Thr Thr Gly Thr Cys Ala Cys Ala Thr Gly Thr Thr Gly Cys Cys 
    850                 855                 860                 


Ala Ala Gly Ala Thr Ala Ala Gly Ala Gly Gly Gly Ala Cys Cys Thr 
865                 870                 875                 880 


Cys Cys Ala Ala Thr Gly Gly Cys Ala Cys Thr Gly Thr Ala Ala Thr 
                885                 890                 895     


Cys Ala Ala Cys Cys Thr Thr Ala Cys Thr Gly Ala Ala Thr Thr Gly 
            900                 905                 910         


Gly Ala Thr Gly Gly Cys Ala Cys Ala Cys Cys Cys Thr Thr Thr Cys 
        915                 920                 925             


Ala Cys Cys Cys Thr Thr Thr Thr Gly Ala Gly Gly Gly Cys Cys Cys 
    930                 935                 940                 


Thr Gly Cys Cys Cys Cys Cys Ala Thr Thr Gly Gly Gly Thr Thr Thr 
945                 950                 955                 960 


Cys Cys Ala Gly Ala Cys Cys Thr Cys Gly Gly Thr Gly Gly Thr Thr 
                965                 970                 975     


Gly Thr Gly Ala Thr Thr Gly Gly Cys Ala Thr Ala Thr Cys Ala Ala 
            980                 985                 990         


Thr Ala Thr Gly Ala Cys Ala Cys  Ala Gly Thr Thr Thr  Gly Gly Cys 
        995                 1000                 1005             


Cys Ala  Thr Thr Cys Thr Ala  Gly Cys Cys Ala Gly  Ala Cys Cys 
    1010                 1015                 1020             


Cys Ala  Gly Thr Ala Thr Gly  Ala Thr Gly Thr Ala  Gly Ala Cys 
    1025                 1030                 1035             


Ala Cys  Cys Ala Cys Cys Cys  Cys Thr Gly Ala Cys  Ala Cys Thr 
    1040                 1045                 1050             


Thr Thr  Thr Gly Thr Cys Cys  Cys Cys Cys Ala Thr  Cys Thr Thr 
    1055                 1060                 1065             


Gly Gly  Thr Thr Cys Ala Ala  Thr Thr Cys Ala Gly  Gly Cys Ala 
    1070                 1075                 1080             


Ala Ala  Thr Gly Gly Cys Ala  Thr Thr Gly Gly Cys  Ala Gly Thr 
    1085                 1090                 1095             


Gly Gly  Thr Ala Ala Thr Thr  Ala Thr Gly Thr Thr  Gly Gly Thr 
    1100                 1105                 1110             


Gly Thr  Thr Cys Thr Thr Ala  Gly Cys Thr Gly Gly  Ala Thr Thr 
    1115                 1120                 1125             


Thr Cys  Cys Cys Cys Cys Cys  Cys Ala Thr Cys Ala  Cys Ala Cys 
    1130                 1135                 1140             


Cys Cys  Gly Thr Cys Thr Gly  Gly Cys Thr Cys Cys  Cys Ala Ala 
    1145                 1150                 1155             


Gly Thr  Thr Gly Ala Cys Cys  Thr Thr Thr Gly Gly  Ala Ala Gly 
    1160                 1165                 1170             


Ala Thr  Cys Cys Cys Cys Ala  Ala Thr Thr Ala Thr  Gly Gly Gly 
    1175                 1180                 1185             


Thr Cys  Ala Ala Gly Thr Ala  Thr Thr Ala Cys Gly  Gly Ala Gly 
    1190                 1195                 1200             


Gly Cys  Ala Ala Cys Ala Cys  Ala Thr Cys Thr Ala  Gly Cys Cys 
    1205                 1210                 1215             


Cys Cys  Thr Thr Cys Thr Gly  Thr Ala Thr Ala Cys  Cys Cys Cys 
    1220                 1225                 1230             


Cys Cys  Thr Gly Gly Thr Thr  Thr Cys Gly Gly Ala  Gly Ala Gly 
    1235                 1240                 1245             


Gly Thr  Ala Thr Thr Gly Gly  Thr Cys Thr Thr Thr  Thr Thr Cys 
    1250                 1255                 1260             


Ala Thr  Gly Thr Cys Ala Ala  Ala Ala Ala Thr Gly  Cys Cys Ala 
    1265                 1270                 1275             


Gly Gly  Thr Cys Cys Thr Gly  Gly Thr Gly Cys Thr  Thr Ala Thr 
    1280                 1285                 1290             


Ala Ala  Thr Thr Thr Gly Cys  Cys Cys Thr Gly Thr  Cys Thr Ala 
    1295                 1300                 1305             


Thr Thr  Ala Cys Cys Ala Cys  Ala Ala Gly Ala Gly  Thr Ala Cys 
    1310                 1315                 1320             


Ala Thr  Thr Thr Cys Ala Cys  Ala Thr Cys Thr Thr  Gly Cys Thr 
    1325                 1330                 1335             


Ala Gly  Thr Gly Ala Ala Cys  Ala Ala Gly Cys Cys  Cys Cys Thr 
    1340                 1345                 1350             


Ala Cys  Thr Gly Thr Ala Gly  Gly Thr Gly Ala Gly  Gly Cys Thr 
    1355                 1360                 1365             


Gly Cys  Cys Cys Thr Gly Cys  Thr Cys Cys Ala Cys  Thr Ala Thr 
    1370                 1375                 1380             


Gly Thr  Thr Gly Ala Cys Cys  Cys Thr Gly Ala Thr  Ala Cys Cys 
    1385                 1390                 1395             


Gly Gly  Thr Cys Gly Gly Ala  Ala Thr Cys Thr Thr  Gly Gly Gly 
    1400                 1405                 1410             


Gly Ala  Ala Thr Thr Cys Ala  Ala Ala Gly Cys Ala  Thr Ala Cys 
    1415                 1420                 1425             


Cys Cys  Thr Gly Ala Thr Gly  Gly Thr Thr Thr Cys  Cys Thr Cys 
    1430                 1435                 1440             


Ala Cys  Thr Thr Gly Thr Gly  Thr Cys Cys Cys Cys  Ala Ala Thr 
    1445                 1450                 1455             


Gly Gly  Gly Gly Cys Thr Ala  Gly Cys Thr Cys Gly  Gly Gly Thr 
    1460                 1465                 1470             


Cys Cys  Ala Cys Ala Ala Cys  Ala Gly Cys Thr Gly  Cys Cys Gly 
    1475                 1480                 1485             


Ala Thr  Cys Ala Ala Thr Gly  Gly Gly Gly Thr Cys  Thr Thr Thr 
    1490                 1495                 1500             


Gly Thr  Cys Thr Thr Thr Gly  Thr Thr Thr Cys Ala  Thr Gly Gly 
    1505                 1510                 1515             


Gly Thr  Gly Thr Cys Cys Ala  Gly Ala Thr Thr Thr  Thr Ala Thr 
    1520                 1525                 1530             


Cys Ala  Ala Thr Thr Ala Ala  Ala Gly Cys Cys Thr  Gly Thr Gly 
    1535                 1540                 1545             


Gly Gly  Ala Ala Cys Thr Gly  Cys Cys Ala Gly Cys  Thr Cys Gly 
    1550                 1555                 1560             


Gly Cys  Ala Ala Gly Ala Gly  Gly Thr Ala Gly Gly  Cys Thr Thr 
    1565                 1570                 1575             


Gly Gly  Thr Cys Thr Gly Cys  Gly Cys Cys Gly Ala  Thr Ala Ala 
    1580                 1585                 1590             


<210>  14
<211>  212
<212>  PRT
<213>  Norovirus GI.1/US/Norwalk/1968

<400>  14

Met Ala Gln Ala Ile Ile Gly Ala Ile Ala Ala Ser Thr Ala Gly Ser 
1               5                   10                  15      


Ala Leu Gly Ala Gly Ile Gln Val Gly Gly Glu Ala Ala Leu Gln Ser 
            20                  25                  30          


Gln Arg Tyr Gln Gln Asn Leu Gln Leu Gln Glu Asn Ser Phe Lys His 
        35                  40                  45              


Asp Arg Glu Met Ile Gly Tyr Gln Val Glu Ala Ser Asn Gln Leu Leu 
    50                  55                  60                  


Ala Lys Asn Leu Ala Thr Arg Tyr Ser Leu Leu Arg Ala Gly Gly Leu 
65                  70                  75                  80  


Thr Ser Ala Asp Ala Ala Arg Ser Val Ala Gly Ala Pro Val Thr Arg 
                85                  90                  95      


Ile Val Asp Trp Asn Gly Val Arg Val Ser Ala Pro Glu Ser Ser Ala 
            100                 105                 110         


Thr Thr Leu Arg Ser Gly Gly Phe Met Ser Val Pro Ile Pro Phe Ala 
        115                 120                 125             


Ser Lys Gln Lys Gln Val Gln Ser Ser Gly Ile Ser Asn Pro Asn Tyr 
    130                 135                 140                 


Ser Pro Ser Ser Ile Ser Arg Thr Thr Ser Trp Val Glu Ser Gln Asn 
145                 150                 155                 160 


Ser Ser Arg Phe Gly Asn Leu Ser Pro Tyr His Ala Glu Ala Leu Asn 
                165                 170                 175     


Thr Val Trp Leu Thr Pro Pro Gly Ser Thr Ala Ser Ser Thr Leu Ser 
            180                 185                 190         


Ser Val Pro Arg Gly Tyr Phe Asn Thr Asp Arg Leu Pro Leu Phe Ala 
        195                 200                 205             


Asn Asn Arg Arg 
    210         


<210>  15
<211>  639
<212>  DNA
<213>  Norovirus GI.1/US/Norwalk/1968

<400>  15
atggcccaag ccataattgg tgcaattgct gcttccacag caggtagtgc tctgggagcg       60

ggcatacagg ttggtggcga agcggccctc caaagccaaa ggtatcaaca aaatttgcaa      120

ctgcaagaaa attcttttaa acatgacagg gaaatgattg ggtatcaggt tgaagcttca      180

aatcaattat tggctaaaaa tttggcaact agatattcac tcctccgtgc tgggggtttg      240

accagtgctg atgcagcaag atctgtggca ggagctccag tcacccgcat tgtagattgg      300

aatggcgtga gagtgtctgc tcccgagtcc tctgctacca cattgagatc cggtggcttc      360

atgtcagttc ccataccatt tgcctctaag caaaaacagg ttcaatcatc tggtattagt      420

aatccaaatt attccccttc atccatttct cgaaccacta gttgggtcga gtcacaaaac      480

tcatcgagat ttggaaatct ttctccatac cacgcggagg ctctcaatac agtgtggttg      540

actccacccg gttcaacagc ctcttctaca ctgtcttctg tgccacgtgg ttatttcaat      600

acagacaggt tgccattatt cgcaaataat aggcgatga                             639


<210>  16
<211>  2231
<212>  DNA
<213>  Norovirus GI.1/US/Norwalk/1968

<400>  16
atgatgatgg cgtctaagga cgctacatca agcgtggatg gcgctagtgg cgctggtcag       60

ttggtaccgg aggttaatgc ttctgaccct cttgcaatgg atcctgtagc aggttcttcg      120

acagcagtcg cgactgctgg acaagttaat cctattgatc cctggataat taataatttt      180

gtgcaagccc cccaaggtga atttactatt tccccaaata atacccccgg tgatgttttg      240

tttgatttga gtttgggtcc ccatcttaat cctttcttgc tccatctatc acaaatgtat      300

aatggttggg ttggtaacat gagagtcagg attatgctag ctggtaatgc ctttactgcg      360

gggaagataa tagtttcctg cataccccct ggttttggtt cacataatct tactatagca      420

caagcaactc tctttccaca tgtgattgct gatgttagga ctctagaccc cattgaggtg      480

cctttggaag atgttaggaa tgttctcttt cataataatg atagaaatca acaaaccatg      540

cgccttgtgt gcatgctgta cacccccctc cgcactggtg gtggtactgg tgattctttt      600

gtagttgcag ggcgagttat gacttgcccc agtcctgatt ttaatttctt gtttttagtc      660

cctcctacgg tggagcagaa aaccaggccc ttcacactcc caaatctgcc attgagttct      720

ctgtctaact cacgtgcccc tctcccaatc agtagtatgg gcatttcccc agacaatgtc      780

cagagtgtgc agttccaaaa tggtcggtgt actctggatg gccgcctggt tggcaccacc      840

ccagtttcat tgtcacatgt tgccaagata agagggacct ccaatggcac tgtaatcaac      900

cttactgaat tggatggcac accctttcac ccttttgagg gccctgcccc cattgggttt      960

ccagacctcg gtggttgtga ttggcatatc aatatgacac agtttggcca ttctagccag     1020

acccagtatg atgtagacac cacccctgac acttttgtcc cccatcttgg ttcaattcag     1080

gcaaatggca ttggcagtgg taattatgtt ggtgttctta gctggatttc ccccccatca     1140

cacccgtctg gctcccaagt tgacctttgg aagatcccca attatgggtc aagtattacg     1200

gaggcaacac atctagcccc ttctgtatac ccccctggtt tcggagaggt attggtcttt     1260

ttcatgtcaa aaatgccagg tcctggtgct tataatttgc cctgtctatt accacaagag     1320

tacatttcac atcttgctag tgaacaagcc cctactgtag gtgaggctgc cctgctccac     1380

tatgttgacc ctgataccgg tcggaatctt ggggaattca aagcataccc tgatggtttc     1440

ctcacttgtg tccccaatgg ggctagctcg ggtccacaac agctgccgat caatggggtc     1500

tttgtctttg tttcatgggt gtccagattt tatcaattaa agcctgtggg aactgccagc     1560

tcggcaagag gtaggcttgg tctgcgccga taatggccca agccataatt ggtgcaattg     1620

ctgcttccac agcaggtagt gctctgggag cgggcataca ggttggtggc gaagcggccc     1680

tccaaagcca aaggtatcaa caaaatttgc aactgcaaga aaattctttt aaacatgaca     1740

gggaaatgat tgggtatcag gttgaagctt caaatcaatt attggctaaa aatttggcaa     1800

ctagatattc actcctccgt gctgggggtt tgaccagtgc tgatgcagca agatctgtgg     1860

caggagctcc agtcacccgc attgtagatt ggaatggcgt gagagtgtct gctcccgagt     1920

cctctgctac cacattgaga tccggtggct tcatgtcagt tcccatacca tttgcctcta     1980

agcaaaaaca ggttcaatca tctggtatta gtaatccaaa ttattcccct tcatccattt     2040

ctcgaaccac tagttgggtc gagtcacaaa actcatcgag atttggaaat ctttctccat     2100

accacgcgga ggctctcaat acagtgtggt tgactccacc cggttcaaca gcctcttcta     2160

cactgtcttc tgtgccacgt ggttatttca atacagacag gttgccatta ttcgcaaata     2220

ataggcgatg a                                                          2231


<210>  17
<211>  2297
<212>  DNA
<213>  Norovirus GI.1/US/Norwalk/1968

<400>  17
atgatgatgg cgtctaagga cgctacatca agcgtggatg gcgctagtgg cgctggtcag       60

ttggtaccgg aggttaatgc ttctgaccct cttgcaatgg atcctgtagc aggttcttcg      120

acagcagtcg cgactgctgg acaagttaat cctattgatc cctggataat taataatttt      180

gtgcaagccc cccaaggtga atttactatt tccccaaata atacccccgg tgatgttttg      240

tttgatttga gtttgggtcc ccatcttaat cctttcttgc tccatctatc acaaatgtat      300

aatggttggg ttggtaacat gagagtcagg attatgctag ctggtaatgc ctttactgcg      360

gggaagataa tagtttcctg cataccccct ggttttggtt cacataatct tactatagca      420

caagcaactc tctttccaca tgtgattgct gatgttagga ctctagaccc cattgaggtg      480

cctttggaag atgttaggaa tgttctcttt cataataatg atagaaatca acaaaccatg      540

cgccttgtgt gcatgctgta cacccccctc cgcactggtg gtggtactgg tgattctttt      600

gtagttgcag ggcgagttat gacttgcccc agtcctgatt ttaatttctt gtttttagtc      660

cctcctacgg tggagcagaa aaccaggccc ttcacactcc caaatctgcc attgagttct      720

ctgtctaact cacgtgcccc tctcccaatc agtagtatgg gcatttcccc agacaatgtc      780

cagagtgtgc agttccaaaa tggtcggtgt actctggatg gccgcctggt tggcaccacc      840

ccagtttcat tgtcacatgt tgccaagata agagggacct ccaatggcac tgtaatcaac      900

cttactgaat tggatggcac accctttcac ccttttgagg gccctgcccc cattgggttt      960

ccagacctcg gtggttgtga ttggcatatc aatatgacac agtttggcca ttctagccag     1020

acccagtatg atgtagacac cacccctgac acttttgtcc cccatcttgg ttcaattcag     1080

gcaaatggca ttggcagtgg taattatgtt ggtgttctta gctggatttc ccccccatca     1140

cacccgtctg gctcccaagt tgacctttgg aagatcccca attatgggtc aagtattacg     1200

gaggcaacac atctagcccc ttctgtatac ccccctggtt tcggagaggt attggtcttt     1260

ttcatgtcaa aaatgccagg tcctggtgct tataatttgc cctgtctatt accacaagag     1320

tacatttcac atcttgctag tgaacaagcc cctactgtag gtgaggctgc cctgctccac     1380

tatgttgacc ctgataccgg tcggaatctt ggggaattca aagcataccc tgatggtttc     1440

ctcacttgtg tccccaatgg ggctagctcg ggtccacaac agctgccgat caatggggtc     1500

tttgtctttg tttcatgggt gtccagattt tatcaattaa agcctgtggg aactgccagc     1560

tcggcaagag gtaggcttgg tctgcgccga taatggccca agccataatt ggtgcaattg     1620

ctgcttccac agcaggtagt gctctgggag cgggcataca ggttggtggc gaagcggccc     1680

tccaaagcca aaggtatcaa caaaatttgc aactgcaaga aaattctttt aaacatgaca     1740

gggaaatgat tgggtatcag gttgaagctt caaatcaatt attggctaaa aatttggcaa     1800

ctagatattc actcctccgt gctgggggtt tgaccagtgc tgatgcagca agatctgtgg     1860

caggagctcc agtcacccgc attgtagatt ggaatggcgt gagagtgtct gctcccgagt     1920

cctctgctac cacattgaga tccggtggct tcatgtcagt tcccatacca tttgcctcta     1980

agcaaaaaca ggttcaatca tctggtatta gtaatccaaa ttattcccct tcatccattt     2040

ctcgaaccac tagttgggtc gagtcacaaa actcatcgag atttggaaat ctttctccat     2100

accacgcgga ggctctcaat acagtgtggt tgactccacc cggttcaaca gcctcttcta     2160

cactgtcttc tgtgccacgt ggttatttca atacagacag gttgccatta ttcgcaaata     2220

ataggcgatg atgttgtaat atgaaatgtg ggcatcatat tcatttaatt aggtttaatt     2280

aggtttaatt tgatgtt                                                    2297


<210>  18
<211>  1593
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP1 G1.1

<400>  18
atgatgatgg ctagtaaaga tgcgacctcc tctgtggatg gtgcgtcagg ggcaggacaa       60

ctcgtacccg aggtaaacgc cagcgaccca cttgccatgg accccgttgc cggaagttcc      120

acagcagtgg ccacagccgg tcaagtgaat ccaattgatc cgtggattat caacaatttc      180

gtccaggcac cccagggcga gttcacaatt tcaccaaaca atacaccggg cgatgtgcta      240

ttcgatcttt ccttgggtcc tcaccttaac ccttttctac tccatctctc acagatgtac      300

aatggttggg taggaaacat gagagtccgg atcatgctgg ctggcaatgc ctttaccgct      360

ggcaagatca tcgtcagttg tattcctccc ggatttggat ctcataatct gaccattgct      420

caagcgactc tctttcccca tgtcatcgcc gacgttagga ccctggaccc catcgaggtg      480

cccctggagg acgtccggaa tgttttgttc cacaacaacg acagaaacca gcagacgatg      540

agacttgtct gtatgctcta taccccactg cggactggag gcgggactgg agactccttc      600

gttgtggcag gaagagtgat gacatgcccc tcccccgact tcaactttct ttttctggtc      660

ccaccaaccg ttgagcagaa gacgcggccc tttacactgc ccaatctccc gctttcaagt      720

ctgagtaatt cacgggcccc attgccgatc tcctcaatgg gaatctcccc cgacaacgtc      780

cagtctgtcc aattccaaaa tgggagatgc acactggacg gtcgcctggt gggaacaact      840

ccggtgtccc tctcacatgt cgccaaaatc cgcggcacat caaatggtac cgtaatcaat      900

ctgacagaac ttgatggcac gcccttccat ccctttgaag gaccagcccc tattggattt      960

cctgatctgg gaggttgcga ctggcacata aacatgacac agtttggcca ctccagccag     1020

acacagtatg atgtcgatac aaccccagat accttcgtgc cacacctggg atctattcaa     1080

gctaacggta ttggatccgg caactacgtg ggagtcttat cttggatctc accaccatcc     1140

cacccctcag gatcccaggt tgacttgtgg aagataccga attatggatc ctcgatcact     1200

gaagccacgc acctcgcacc ttccgtctac ccaccaggtt ttggagaagt cttggtgttt     1260

ttcatgagca aaatgcccgg ccctggagcc tacaatctcc cttgcctact ccctcaagag     1320

tatattagtc acctcgcatc tgagcaggcc ccgaccgttg gcgaggcagc cctgctgcat     1380

tatgtggatc cggacaccgg caggaacctg ggtgagttca aagcttatcc tgacggtttt     1440

ctaacatgtg taccaaatgg cgcttccagc ggccctcaac agctcccaat caatggcgtg     1500

ttcgtttttg tcagctgggt aagccgcttc taccagctga agcccgtggg gacagcttct     1560

tctgcccgcg gacgcctcgg tctgcggaga taa                                  1593


<210>  19
<211>  639
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP2 G1.1

<400>  19
atggctcagg ccattattgg cgccatcgct gcaagtacag ccgggagtgc attgggggcc       60

ggaatacagg tgggcgggga agctgcattg cagagccagc ggtaccagca aaacctgcag      120

ttacaggaga atagctttaa acacgacagg gagatgattg gatatcaggt ggaggccagc      180

aatcagctgc tcgccaaaaa cttggctact cgatactcat tactgcgcgc cggggggttg      240

actagcgccg acgccgcacg atctgtcgca ggcgcccccg tgactcggat cgtagactgg      300

aacggggtac gagtctcggc tcccgagtcg tctgcaacca ccctgaggtc gggagggttt      360

atgtccgtgc ccatcccatt cgctagcaaa cagaaacagg tccagagctc cggaatctcc      420

aatcccaatt actcccctag ctctatctct cgtaccactt cctgggtcga gagtcagaac      480

agcagtagat ttggcaacct gagcccctac catgctgaag ccctgaacac tgtgtggttg      540

actccacctg gtagcacggc ctcctcaacc ctgagttccg tgcctcgcgg gtacttcaat      600

accgacagac ttcctctgtt cgctaacaac cgccgctga                             639


<210>  20
<211>  2231
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP1/VP2 G1.1

<400>  20
atgatgatgg ctagtaaaga tgcgacctcc tctgtggatg gtgcgtcagg ggcaggacaa       60

ctcgtacccg aggtaaacgc cagcgaccca cttgccatgg accccgttgc cggaagttcc      120

acagcagtgg ccacagccgg tcaagtgaat ccaattgatc cgtggattat caacaatttc      180

gtccaggcac cccagggcga gttcacaatt tcaccaaaca atacaccggg cgatgtgcta      240

ttcgatcttt ccttgggtcc tcaccttaac ccttttctac tccatctctc acagatgtac      300

aatggttggg taggaaacat gagagtccgg atcatgctgg ctggcaatgc ctttaccgct      360

ggcaagatca tcgtcagttg tattcctccc ggatttggat ctcataatct gaccattgct      420

caagcgactc tctttcccca tgtcatcgcc gacgttagga ccctggaccc catcgaggtg      480

cccctggagg acgtccggaa tgttttgttc cacaacaacg acagaaacca gcagacgatg      540

agacttgtct gtatgctcta taccccactg cggactggag gcgggactgg agactccttc      600

gttgtggcag gaagagtgat gacatgcccc tcccccgact tcaactttct ttttctggtc      660

ccaccaaccg ttgagcagaa gacgcggccc tttacactgc ccaatctccc gctttcaagt      720

ctgagtaatt cacgggcccc attgccgatc tcctcaatgg gaatctcccc cgacaacgtc      780

cagtctgtcc aattccaaaa tgggagatgc acactggacg gtcgcctggt gggaacaact      840

ccggtgtccc tctcacatgt cgccaaaatc cgcggcacat caaatggtac cgtaatcaat      900

ctgacagaac ttgatggcac gcccttccat ccctttgaag gaccagcccc tattggattt      960

cctgatctgg gaggttgcga ctggcacata aacatgacac agtttggcca ctccagccag     1020

acacagtatg atgtcgatac aaccccagat accttcgtgc cacacctggg atctattcaa     1080

gctaacggta ttggatccgg caactacgtg ggagtcttat cttggatctc accaccatcc     1140

cacccctcag gatcccaggt tgacttgtgg aagataccga attatggatc ctcgatcact     1200

gaagccacgc acctcgcacc ttccgtctac ccaccaggtt ttggagaagt cttggtgttt     1260

ttcatgagca aaatgcccgg ccctggagcc tacaatctcc cttgcctact ccctcaagag     1320

tatattagtc acctcgcatc tgagcaggcc ccgaccgttg gcgaggcagc cctgctgcat     1380

tatgtggatc cggacaccgg caggaacctg ggtgagttca aagcttatcc tgacggtttt     1440

ctaacatgtg taccaaatgg cgcttccagc ggccctcaac agctcccaat caatggcgtg     1500

ttcgtttttg tcagctgggt aagccgcttc taccagctga agcccgtggg gacagcttct     1560

tctgcccgcg gacgcctcgg tctgcggaga taatggctca ggccattatt ggcgccatcg     1620

ctgcaagtac agccgggagt gcattggggg ccggaataca ggtgggcggg gaagctgcat     1680

tgcagagcca gcggtaccag caaaacctgc agttacagga gaatagcttt aaacacgaca     1740

gggagatgat tggatatcag gtggaggcca gcaatcagct gctcgccaaa aacttggcta     1800

ctcgatactc attactgcgc gccggggggt tgactagcgc cgacgccgca cgatctgtcg     1860

caggcgcccc cgtgactcgg atcgtagact ggaacggggt acgagtctcg gctcccgagt     1920

cgtctgcaac caccctgagg tcgggagggt ttatgtccgt gcccatccca ttcgctagca     1980

aacagaaaca ggtccagagc tccggaatct ccaatcccaa ttactcccct agctctatct     2040

ctcgtaccac ttcctgggtc gagagtcaga acagcagtag atttggcaac ctgagcccct     2100

accatgctga agccctgaac actgtgtggt tgactccacc tggtagcacg gcctcctcaa     2160

ccctgagttc cgtgcctcgc gggtacttca ataccgacag acttcctctg ttcgctaaca     2220

accgccgctg a                                                          2231


<210>  21
<211>  2297
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP1/VP2/3'UTR G1.1

<400>  21
atgatgatgg ctagtaaaga tgcgacctcc tctgtggatg gtgcgtcagg ggcaggacaa       60

ctcgtacccg aggtaaacgc cagcgaccca cttgccatgg accccgttgc cggaagttcc      120

acagcagtgg ccacagccgg tcaagtgaat ccaattgatc cgtggattat caacaatttc      180

gtccaggcac cccagggcga gttcacaatt tcaccaaaca atacaccggg cgatgtgcta      240

ttcgatcttt ccttgggtcc tcaccttaac ccttttctac tccatctctc acagatgtac      300

aatggttggg taggaaacat gagagtccgg atcatgctgg ctggcaatgc ctttaccgct      360

ggcaagatca tcgtcagttg tattcctccc ggatttggat ctcataatct gaccattgct      420

caagcgactc tctttcccca tgtcatcgcc gacgttagga ccctggaccc catcgaggtg      480

cccctggagg acgtccggaa tgttttgttc cacaacaacg acagaaacca gcagacgatg      540

agacttgtct gtatgctcta taccccactg cggactggag gcgggactgg agactccttc      600

gttgtggcag gaagagtgat gacatgcccc tcccccgact tcaactttct ttttctggtc      660

ccaccaaccg ttgagcagaa gacgcggccc tttacactgc ccaatctccc gctttcaagt      720

ctgagtaatt cacgggcccc attgccgatc tcctcaatgg gaatctcccc cgacaacgtc      780

cagtctgtcc aattccaaaa tgggagatgc acactggacg gtcgcctggt gggaacaact      840

ccggtgtccc tctcacatgt cgccaaaatc cgcggcacat caaatggtac cgtaatcaat      900

ctgacagaac ttgatggcac gcccttccat ccctttgaag gaccagcccc tattggattt      960

cctgatctgg gaggttgcga ctggcacata aacatgacac agtttggcca ctccagccag     1020

acacagtatg atgtcgatac aaccccagat accttcgtgc cacacctggg atctattcaa     1080

gctaacggta ttggatccgg caactacgtg ggagtcttat cttggatctc accaccatcc     1140

cacccctcag gatcccaggt tgacttgtgg aagataccga attatggatc ctcgatcact     1200

gaagccacgc acctcgcacc ttccgtctac ccaccaggtt ttggagaagt cttggtgttt     1260

ttcatgagca aaatgcccgg ccctggagcc tacaatctcc cttgcctact ccctcaagag     1320

tatattagtc acctcgcatc tgagcaggcc ccgaccgttg gcgaggcagc cctgctgcat     1380

tatgtggatc cggacaccgg caggaacctg ggtgagttca aagcttatcc tgacggtttt     1440

ctaacatgtg taccaaatgg cgcttccagc ggccctcaac agctcccaat caatggcgtg     1500

ttcgtttttg tcagctgggt aagccgcttc taccagctga agcccgtggg gacagcttct     1560

tctgcccgcg gacgcctcgg tctgcggaga taatggctca ggccattatt ggcgccatcg     1620

ctgcaagtac agccgggagt gcattggggg ccggaataca ggtgggcggg gaagctgcat     1680

tgcagagcca gcggtaccag caaaacctgc agttacagga gaatagcttt aaacacgaca     1740

gggagatgat tggatatcag gtggaggcca gcaatcagct gctcgccaaa aacttggcta     1800

ctcgatactc attactgcgc gccggggggt tgactagcgc cgacgccgca cgatctgtcg     1860

caggcgcccc cgtgactcgg atcgtagact ggaacggggt acgagtctcg gctcccgagt     1920

cgtctgcaac caccctgagg tcgggagggt ttatgtccgt gcccatccca ttcgctagca     1980

aacagaaaca ggtccagagc tccggaatct ccaatcccaa ttactcccct agctctatct     2040

ctcgtaccac ttcctgggtc gagagtcaga acagcagtag atttggcaac ctgagcccct     2100

accatgctga agccctgaac actgtgtggt tgactccacc tggtagcacg gcctcctcaa     2160

ccctgagttc cgtgcctcgc gggtacttca ataccgacag acttcctctg ttcgctaaca     2220

accgccgctg atgttgtaat atgaaatgtg ggcatcatat tcatttaatt aggtttaatt     2280

aggtttaatt tgatgtt                                                    2297


<210>  22
<211>  545
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GI.1)+P(GI.2) fusion VP1

<400>  22

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Gln Lys Thr Arg Ala Phe Thr Val Pro Asn Ile Pro Leu Gln Thr 
225                 230                 235                 240 


Leu Ser Asn Ser Arg Phe Pro Ser Leu Ile Gln Gly Met Ile Leu Ser 
                245                 250                 255     


Pro Asp Ala Ser Gln Val Val Gln Phe Gln Asn Gly Arg Cys Leu Ile 
            260                 265                 270         


Asp Gly Gln Leu Leu Gly Thr Thr Pro Ala Thr Ser Gly Gln Leu Phe 
        275                 280                 285             


Arg Val Arg Gly Lys Ile Asn Gln Gly Ala Arg Thr Leu Asn Leu Thr 
    290                 295                 300                 


Glu Val Asp Gly Lys Pro Phe Met Ala Phe Asp Ser Pro Ala Pro Val 
305                 310                 315                 320 


Gly Phe Pro Asp Phe Gly Lys Cys Asp Trp His Met Arg Ile Ser Lys 
                325                 330                 335     


Thr Pro Asn Asn Thr Ser Ser Gly Asp Pro Met Arg Ser Val Asp Val 
            340                 345                 350         


Gln Thr Asp Val Gln Gly Phe Val Pro His Leu Gly Ser Ile Gln Phe 
        355                 360                 365             


Asp Glu Val Phe Asn His Pro Thr Gly Asp Tyr Ile Gly Thr Ile Glu 
    370                 375                 380                 


Trp Ile Ser Gln Pro Ser Thr Pro Pro Gly Thr Asp Ile Asn Leu Trp 
385                 390                 395                 400 


Glu Ile Pro Asp Tyr Gly Ser Ser Leu Ser Gln Ala Ala Asn Leu Ala 
                405                 410                 415     


Pro Pro Val Phe Pro Pro Gly Phe Gly Glu Ala Leu Val Tyr Phe Val 
            420                 425                 430         


Ser Ala Phe Pro Gly Pro Asn Asn Arg Ser Ala Pro Asn Asp Val Pro 
        435                 440                 445             


Cys Leu Leu Pro Gln Glu Tyr Val Thr His Phe Val Ser Glu Gln Ala 
    450                 455                 460                 


Pro Thr Met Gly Asp Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr 
465                 470                 475                 480 


Asn Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu Thr 
                485                 490                 495     


Cys Val Pro Asn Gly Val Gly Ala Gly Pro Gln Gln Leu Pro Leu Asn 
            500                 505                 510         


Gly Val Phe Leu Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys 
        515                 520                 525             


Pro Val Gly Thr Ala Ser Thr Ala Arg Gly Arg Leu Gly Val Arg Arg 
    530                 535                 540                 


Ile 
545 


<210>  23
<211>  542
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GI.1)+P(GI.3) fusion VP1

<400>  23

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Gln Lys Thr Lys Pro Phe Ser Val Pro Asn Leu Pro Leu Asn Val 
225                 230                 235                 240 


Leu Ser Asn Ser Arg Val Pro Ser Leu Ile Lys Ser Met Met Val Ser 
                245                 250                 255     


Gln Asp His Gly Gln Met Val Gln Phe Gln Asn Gly Arg Val Thr Leu 
            260                 265                 270         


Asp Gly Gln Leu Gln Gly Thr Thr Pro Thr Ser Ala Ser Gln Leu Cys 
        275                 280                 285             


Lys Ile Arg Gly Thr Val Tyr His Ala Thr Gly Gly Gln Gly Leu Asn 
    290                 295                 300                 


Leu Thr Glu Ile Asp Gly Thr Pro Tyr His Ala Phe Glu Ser Pro Ala 
305                 310                 315                 320 


Pro Ile Gly Phe Pro Asp Leu Gly Glu Cys Asp Trp His Ile Asn Ala 
                325                 330                 335     


Ser Pro Ala Asn Ala Phe Thr Asp Gly Ser Ile Ile His Arg Ile Asp 
            340                 345                 350         


Val Ala Gln Asp Ser Thr Phe Ala Pro His Leu Gly Thr Ile His Tyr 
        355                 360                 365             


Thr Asn Ala Asp Tyr Asn Ala Asn Val Gly Leu Ile Cys Ser Leu Glu 
    370                 375                 380                 


Trp Leu Ser Pro Pro Ser Gly Gly Ala Pro Lys Val Asn Pro Trp Ala 
385                 390                 395                 400 


Ile Pro Arg Tyr Gly Ser Thr Leu Thr Glu Ala Ala Gln Leu Ala Pro 
                405                 410                 415     


Pro Ile Tyr Pro Pro Gly Phe Gly Glu Ala Ile Val Phe Phe Met Ser 
            420                 425                 430         


Asp Phe Pro Ile Ala Asn Gly Ser Asp Gly Leu Ser Val Pro Cys Thr 
        435                 440                 445             


Ile Pro Gln Glu Phe Val Thr His Phe Val Asn Glu Gln Ala Pro Thr 
    450                 455                 460                 


Arg Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr His Arg 
465                 470                 475                 480 


Asn Leu Gly Glu Phe Lys Leu Tyr Pro Glu Gly Phe Met Thr Cys Val 
                485                 490                 495     


Pro Asn Ser Ser Gly Ser Gly Pro Gln Thr Leu Pro Ile Asn Gly Val 
            500                 505                 510         


Phe Thr Phe Ile Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val 
        515                 520                 525             


Gly Thr Thr Gly Pro Val Arg Arg Leu Gly Ile Arg Arg Ser 
    530                 535                 540         


<210>  24
<211>  544
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GI.1)+P(GII.4) fusion VP1

<400>  24

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Ser Arg Thr Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu 
225                 230                 235                 240 


Met Thr Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly 
                245                 250                 255     


Pro Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr 
            260                 265                 270         


Asp Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys 
        275                 280                 285             


Thr Phe Arg Gly Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr 
    290                 295                 300                 


Met Asn Leu Ala Ser Gln Asn Trp Asn Asp Tyr Asp Pro Thr Glu Glu 
305                 310                 315                 320 


Ile Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly 
                325                 330                 335     


Val Leu Thr Gln Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys 
            340                 345                 350         


Ala Thr Val Tyr Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly Arg 
        355                 360                 365             


Val Gln Phe Glu Thr Asp Thr Asp Arg Asp Phe Glu Ala Asn Gln Asn 
    370                 375                 380                 


Thr Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Gly Thr Thr His 
385                 390                 395                 400 


Arg Asn Glu Pro Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn 
                405                 410                 415     


Thr His Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly 
            420                 425                 430         


Glu Gln Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr 
        435                 440                 445             


Pro Asn Met Asp Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr 
    450                 455                 460                 


Phe Tyr Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg 
465                 470                 475                 480 


Phe Val Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His 
                485                 490                 495     


Lys Ser Gly Tyr Val Thr Val Ala His Thr Gly Gln His Asp Leu Val 
            500                 505                 510         


Ile Pro Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe 
        515                 520                 525             


Tyr Thr Leu Ala Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Val 
    530                 535                 540                 


<210>  25
<211>  552
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GI.1)+P(GII.6) fusion VP1

<400>  25

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Ser Lys Thr Lys Pro Phe Ser Leu Pro Ile Leu Thr Leu Gly Glu 
225                 230                 235                 240 


Leu Ser Asn Ser Arg Phe Pro Ala Pro Ile Asp Met Leu Tyr Thr Asp 
                245                 250                 255     


Pro Asn Glu Gly Ile Val Val Gln Pro Gln Asn Gly Arg Cys Thr Leu 
            260                 265                 270         


Asp Gly Thr Leu Gln Gly Thr Thr Gln Leu Val Pro Thr Gln Ile Cys 
        275                 280                 285             


Ala Phe Arg Gly Thr Leu Ile Gly Gln Thr Ser Arg Ser Pro Asp Ser 
    290                 295                 300                 


Thr Asp Ser Ala Pro Arg Arg Arg Asp His Pro Leu His Val Gln Leu 
305                 310                 315                 320 


Lys Asn Leu Asp Gly Thr Gln Tyr Asp Pro Thr Asp Glu Val Pro Ala 
                325                 330                 335     


Val Leu Gly Ala Ile Asp Phe Lys Gly Thr Val Phe Gly Val Ala Ser 
            340                 345                 350         


Gln Arg Asp Val Ser Gly Gln Gln Val Gly Ala Thr Arg Ala His Glu 
        355                 360                 365             


Val His Ile Asn Thr Thr Asp Pro Arg Tyr Thr Pro Lys Leu Gly Ser 
    370                 375                 380                 


Ile Leu Met Tyr Ser Glu Ser Asp Asp Phe Val Thr Gly Gln Pro Val 
385                 390                 395                 400 


Arg Phe Thr Pro Ile Gly Met Gly Asp Asn Asp Trp His Gln Trp Glu 
                405                 410                 415     


Leu Pro Asp Tyr Pro Gly His Leu Thr Leu Asn Met Asn Leu Ala Pro 
            420                 425                 430         


Ala Val Ala Pro Ala Phe Pro Gly Glu Arg Ile Leu Phe Phe Arg Ser 
        435                 440                 445             


Ile Val Pro Ser Ala Gly Gly Tyr Gly Ser Gly Gln Ile Asp Cys Leu 
    450                 455                 460                 


Ile Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu Ala Ala Pro Ser 
465                 470                 475                 480 


Gln Ser Ala Val Ala Leu Ile Arg Tyr Val Asn Pro Asp Thr Gly Arg 
                485                 490                 495     


Asn Ile Phe Glu Ala Lys Leu His Arg Glu Gly Phe Ile Thr Val Ala 
            500                 505                 510         


Asn Ser Gly Asn Asn Pro Ile Val Val Pro Pro Asn Gly Tyr Phe Arg 
        515                 520                 525             


Phe Glu Ala Trp Val Asn Gln Phe Tyr Thr Leu Thr Pro Met Gly Thr 
    530                 535                 540                 


Gly Gln Gly Arg Arg Arg Asp Gln 
545                 550         


<210>  26
<211>  546
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GI.1)+P(GII.13) fusion VP1

<400>  26

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Ser Lys Thr Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Ser Glu 
225                 230                 235                 240 


Leu Thr Asn Ser Arg Phe Pro Ile Ser Ile Glu Gln Leu Tyr Thr Ala 
                245                 250                 255     


Pro Asn Glu Asn Asn Val Val Gln Cys Gln Asn Gly Arg Cys Thr Leu 
            260                 265                 270         


Asp Gly Glu Leu Gln Gly Thr Thr Gln Leu Leu Ser Ser Ala Val Cys 
        275                 280                 285             


Ser Tyr Arg Gly Arg Thr Val Ala Asn Ser Gly Asp Asn Trp Asp Gln 
    290                 295                 300                 


Asn Val Leu Gln Leu Thr Tyr Pro Ser Gly Ala Ser Tyr Asp Pro Thr 
305                 310                 315                 320 


Asp Glu Val Pro Ala Pro Leu Gly Thr Gln Asp Phe Ser Gly Ile Leu 
                325                 330                 335     


Tyr Gly Val Leu Thr Gln Asp Asn Val Arg Glu Asn Thr Gly Glu Ala 
            340                 345                 350         


Lys Asn Ala Lys Gly Val Tyr Ile Ser Thr Thr Ser Gly Lys Phe Thr 
        355                 360                 365             


Pro Lys Ile Gly Ser Ile Gly Leu His Ser Ile Thr Glu Asp Val Arg 
    370                 375                 380                 


Pro Asn Gln Gln Ser Arg Phe Thr Pro Val Gly Val Ala Gln Asn Glu 
385                 390                 395                 400 


Asn Thr Pro Phe Gln Gln Trp Val Leu Pro His Tyr Ala Gly Ala Leu 
                405                 410                 415     


Ala Leu Asn Thr Asn Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly 
            420                 425                 430         


Glu Gln Leu Leu Phe Phe Arg Ser Arg Val Pro Cys Val Gln Gly Leu 
        435                 440                 445             


Gln Gly Gln Asp Ala Phe Ile Asp Cys Leu Leu Pro Gln Glu Trp Val 
    450                 455                 460                 


Asn His Phe Tyr Gln Glu Ala Ala Pro Ser Gln Ala Asp Val Ala Leu 
465                 470                 475                 480 


Ile Arg Tyr Val Asn Pro Asp Thr Gly Arg Thr Leu Phe Glu Ala Lys 
                485                 490                 495     


Leu His Arg Ser Gly Phe Ile Thr Val Ser His Thr Gly Ala Tyr Pro 
            500                 505                 510         


Leu Val Val Pro Pro Asn Gly His Phe Arg Phe Asp Ser Trp Val Asn 
        515                 520                 525             


Gln Phe Tyr Ser Leu Ala Pro Met Gly Thr Gly Asn Gly Arg Arg Arg 
    530                 535                 540                 


Val Gln 
545     


<210>  27
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GI.1)+P(GII.17) fusion VP1

<400>  27

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Gln Lys Thr Arg Pro Phe Thr Leu Pro Asn Leu Pro Leu Ser Ser 
225                 230                 235                 240 


Leu Ser Asn Ser Arg Ala Pro Leu Pro Ile Ser Ser Met Gly Ile Ser 
                245                 250                 255     


Pro Asp Asn Val Gln Ser Val Gln Phe Gln Asn Gly Arg Cys Thr Leu 
            260                 265                 270         


Asp Gly Arg Leu Val Gly Thr Thr Gln Leu Leu Pro Ser Gly Ile Cys 
        275                 280                 285             


Ala Phe Arg Gly Arg Val Thr Ala Glu Thr Asp His Arg Asp Lys Trp 
    290                 295                 300                 


His Met Gln Leu Gln Asn Leu Asn Gly Thr Thr Tyr Asp Pro Thr Asp 
305                 310                 315                 320 


Asp Val Pro Ala Pro Leu Gly Thr Pro Asp Phe Lys Gly Val Val Phe 
                325                 330                 335     


Gly Val Ala Ser Gln Arg Asn Val Gly Asn Asp Ala Pro Gly Ser Thr 
            340                 345                 350         


Arg Ala His Glu Ala Val Ile Ser Thr Tyr Ser Pro Gln Phe Val Pro 
        355                 360                 365             


Lys Leu Gly Ser Val Asn Phe Arg Ser Asn Asp Asn Asp Phe Gln Leu 
    370                 375                 380                 


Gln Pro Thr Lys Phe Thr Pro Val Gly Ile Asn Asp Asp Gly Asp His 
385                 390                 395                 400 


Pro Phe Arg Gln Trp Glu Leu Pro Asp Tyr Ser Gly Leu Leu Thr Leu 
                405                 410                 415     


Asn Met Asn Leu Ala Pro Ser Val Tyr Pro Pro Gly Phe Gly Glu Val 
            420                 425                 430         


Leu Val Phe Phe Met Ser Lys Met Pro Gly Pro Gly Ala Tyr Asn Leu 
        435                 440                 445             


Pro Cys Leu Leu Pro Gln Glu Tyr Ile Ser His Leu Ala Ser Glu Gln 
    450                 455                 460                 


Ala Pro Thr Val Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp 
465                 470                 475                 480 


Thr Gly Arg Asn Leu Gly Glu Phe Lys Ala Tyr Pro Asp Gly Phe Leu 
                485                 490                 495     


Thr Cys Val Pro Asn Gly Ala Ser Ser Gly Pro Gln Gln Leu Pro Ile 
            500                 505                 510         


Asn Gly Val Phe Val Phe Val Ser 
        515                 520 


<210>  28
<211>  535
<212>  PRT
<213>  Norovirus GII.12/HS206/2010/USA

<400>  28

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Glu Leu Tyr Thr Ser Pro Asn Glu Ser 
                245                 250                 255     


Leu Val Val Gln Pro Gln Asn Gly Arg Cys Ala Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Pro Thr Ala Ile Cys Ser Phe Arg Gly 
        275                 280                 285             


Arg Ile Asn Gln Lys Val Ser Gly Glu Asn His Val Trp Asn Met Gln 
    290                 295                 300                 


Val Thr Asn Ile Asp Gly Thr Pro Phe Asp Pro Thr Glu Asp Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Thr Pro Asp Phe Ser Gly Lys Leu Phe Gly Val Leu 
                325                 330                 335     


Ser Gln Arg Asp His Asp Asn Ala Cys Arg Ser His Asp Ala Val Ile 
            340                 345                 350         


Ala Thr Asn Ser Ala Lys Phe Thr Pro Lys Leu Gly Ala Ile Gln Ile 
        355                 360                 365             


Gly Thr Trp Glu Gln Asp Asp Val His Ile Asn Gln Pro Thr Lys Phe 
    370                 375                 380                 


Thr Pro Val Gly Leu Phe Glu Ser Glu Gly Phe Asn Gln Trp Thr Leu 
385                 390                 395                 400 


Pro Asn Tyr Ser Gly Ala Leu Thr Leu Asn Met Gly Leu Ala Pro Pro 
                405                 410                 415     


Val Ala Pro Thr Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser His 
            420                 425                 430         


Ile Pro Leu Lys Gly Gly Val Ala Asp Pro Val Ile Asp Cys Leu Leu 
        435                 440                 445             


Pro Gln Glu Trp Ile Gln His Leu Tyr Gln Glu Ser Ala Pro Ser Gln 
    450                 455                 460                 


Thr Asp Val Ala Leu Ile Arg Phe Thr Asn Pro Asp Thr Gly Arg Val 
465                 470                 475                 480 


Leu Phe Glu Ala Lys Leu His Arg Ser Gly Tyr Ile Thr Val Ala Asn 
                485                 490                 495     


Thr Gly Ser Arg Pro Ile Val Val Pro Ala Asn Gly Tyr Phe Arg Phe 
            500                 505                 510         


Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Met Gly Thr Gly 
        515                 520                 525             


Asn Gly Arg Arg Arg Val Gln 
    530                 535 


<210>  29
<211>  526
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GI.1) fusion VP1

<400>  29

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Gln Lys Thr 
    210                 215                 220                 


Arg Pro Phe Thr Leu Pro Asn Leu Pro Leu Ser Ser Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Ala Pro Leu Pro Ile Ser Ser Met Gly Ile Ser Pro Asp Asn Val 
                245                 250                 255     


Gln Ser Val Gln Phe Gln Asn Gly Arg Cys Thr Leu Asp Gly Arg Leu 
            260                 265                 270         


Val Gly Thr Thr Pro Val Ser Leu Ser His Val Ala Lys Ile Arg Gly 
        275                 280                 285             


Thr Ser Asn Gly Thr Val Ile Asn Leu Thr Glu Leu Asp Gly Thr Pro 
    290                 295                 300                 


Phe His Pro Phe Glu Gly Pro Ala Pro Ile Gly Phe Pro Asp Leu Gly 
305                 310                 315                 320 


Gly Cys Asp Trp His Ile Asn Met Thr Gln Phe Gly His Ser Ser Gln 
                325                 330                 335     


Thr Gln Tyr Asp Val Asp Thr Thr Pro Asp Thr Phe Val Pro His Leu 
            340                 345                 350         


Gly Ser Ile Gln Ala Asn Gly Ile Gly Ser Gly Asn Tyr Val Gly Val 
        355                 360                 365             


Leu Ser Trp Ile Ser Pro Pro Ser His Pro Ser Gly Ser Gln Val Asp 
    370                 375                 380                 


Leu Trp Lys Ile Pro Asn Tyr Gly Ser Ser Ile Thr Glu Ala Thr His 
385                 390                 395                 400 


Leu Ala Pro Ser Val Tyr Pro Pro Gly Phe Gly Glu Val Leu Val Phe 
                405                 410                 415     


Phe Met Ser Lys Met Pro Gly Pro Gly Ala Tyr Asn Leu Pro Cys Leu 
            420                 425                 430         


Leu Pro Gln Glu Tyr Ile Ser His Leu Ala Ser Glu Gln Ala Pro Thr 
        435                 440                 445             


Val Gly Glu Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr Gly Arg 
    450                 455                 460                 


Asn Leu Gly Glu Phe Lys Ala Tyr Pro Asp Gly Phe Leu Thr Cys Val 
465                 470                 475                 480 


Pro Asn Gly Ala Ser Ser Gly Pro Gln Gln Leu Pro Ile Asn Gly Val 
                485                 490                 495     


Phe Val Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val 
            500                 505                 510         


Gly Thr Ala Ser Ser Ala Arg Gly Arg Leu Gly Leu Arg Arg 
        515                 520                 525     


<210>  30
<211>  541
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GI.2)fusion VP1

<400>  30

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Gln Lys Thr 
    210                 215                 220                 


Arg Ala Phe Thr Val Pro Asn Ile Pro Leu Gln Thr Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ser Leu Ile Gln Gly Met Ile Leu Ser Pro Asp Ala Ser 
                245                 250                 255     


Gln Val Val Gln Phe Gln Asn Gly Arg Cys Leu Ile Asp Gly Gln Leu 
            260                 265                 270         


Leu Gly Thr Thr Pro Ala Thr Ser Gly Gln Leu Phe Arg Val Arg Gly 
        275                 280                 285             


Lys Ile Asn Gln Gly Ala Arg Thr Leu Asn Leu Thr Glu Val Asp Gly 
    290                 295                 300                 


Lys Pro Phe Met Ala Phe Asp Ser Pro Ala Pro Val Gly Phe Pro Asp 
305                 310                 315                 320 


Phe Gly Lys Cys Asp Trp His Met Arg Ile Ser Lys Thr Pro Asn Asn 
                325                 330                 335     


Thr Ser Ser Gly Asp Pro Met Arg Ser Val Asp Val Gln Thr Asp Val 
            340                 345                 350         


Gln Gly Phe Val Pro His Leu Gly Ser Ile Gln Phe Asp Glu Val Phe 
        355                 360                 365             


Asn His Pro Thr Gly Asp Tyr Ile Gly Thr Ile Glu Trp Ile Ser Gln 
    370                 375                 380                 


Pro Ser Thr Pro Pro Gly Thr Asp Ile Asn Leu Trp Glu Ile Pro Asp 
385                 390                 395                 400 


Tyr Gly Ser Ser Leu Ser Gln Ala Ala Asn Leu Ala Pro Pro Val Phe 
                405                 410                 415     


Pro Pro Gly Phe Gly Glu Ala Leu Val Tyr Phe Val Ser Ala Phe Pro 
            420                 425                 430         


Gly Pro Asn Asn Arg Ser Ala Pro Asn Asp Val Pro Cys Leu Leu Pro 
        435                 440                 445             


Gln Glu Tyr Val Thr His Phe Val Ser Glu Gln Ala Pro Thr Met Gly 
    450                 455                 460                 


Asp Ala Ala Leu Leu His Tyr Val Asp Pro Asp Thr Asn Arg Asn Leu 
465                 470                 475                 480 


Gly Glu Phe Lys Leu Tyr Pro Gly Gly Tyr Leu Thr Cys Val Pro Asn 
                485                 490                 495     


Gly Val Gly Ala Gly Pro Gln Gln Leu Pro Leu Asn Gly Val Phe Leu 
            500                 505                 510         


Phe Val Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val Gly Thr 
        515                 520                 525             


Ala Ser Thr Ala Arg Gly Arg Leu Gly Val Arg Arg Ile 
    530                 535                 540     


<210>  31
<211>  538
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GI.3) fusion VP1

<400>  31

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Gln Lys Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Asn Leu Pro Leu Asn Val Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Val Pro Ser Leu Ile Lys Ser Met Met Val Ser Gln Asp His Gly 
                245                 250                 255     


Gln Met Val Gln Phe Gln Asn Gly Arg Val Thr Leu Asp Gly Gln Leu 
            260                 265                 270         


Gln Gly Thr Thr Pro Thr Ser Ala Ser Gln Leu Cys Lys Ile Arg Gly 
        275                 280                 285             


Thr Val Tyr His Ala Thr Gly Gly Gln Gly Leu Asn Leu Thr Glu Ile 
    290                 295                 300                 


Asp Gly Thr Pro Tyr His Ala Phe Glu Ser Pro Ala Pro Ile Gly Phe 
305                 310                 315                 320 


Pro Asp Leu Gly Glu Cys Asp Trp His Ile Asn Ala Ser Pro Ala Asn 
                325                 330                 335     


Ala Phe Thr Asp Gly Ser Ile Ile His Arg Ile Asp Val Ala Gln Asp 
            340                 345                 350         


Ser Thr Phe Ala Pro His Leu Gly Thr Ile His Tyr Thr Asn Ala Asp 
        355                 360                 365             


Tyr Asn Ala Asn Val Gly Leu Ile Cys Ser Leu Glu Trp Leu Ser Pro 
    370                 375                 380                 


Pro Ser Gly Gly Ala Pro Lys Val Asn Pro Trp Ala Ile Pro Arg Tyr 
385                 390                 395                 400 


Gly Ser Thr Leu Thr Glu Ala Ala Gln Leu Ala Pro Pro Ile Tyr Pro 
                405                 410                 415     


Pro Gly Phe Gly Glu Ala Ile Val Phe Phe Met Ser Asp Phe Pro Ile 
            420                 425                 430         


Ala Asn Gly Ser Asp Gly Leu Ser Val Pro Cys Thr Ile Pro Gln Glu 
        435                 440                 445             


Phe Val Thr His Phe Val Asn Glu Gln Ala Pro Thr Arg Gly Glu Ala 
    450                 455                 460                 


Ala Leu Leu His Tyr Val Asp Pro Asp Thr His Arg Asn Leu Gly Glu 
465                 470                 475                 480 


Phe Lys Leu Tyr Pro Glu Gly Phe Met Thr Cys Val Pro Asn Ser Ser 
                485                 490                 495     


Gly Ser Gly Pro Gln Thr Leu Pro Ile Asn Gly Val Phe Thr Phe Ile 
            500                 505                 510         


Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val Gly Thr Thr Gly 
        515                 520                 525             


Pro Val Arg Arg Leu Gly Ile Arg Arg Ser 
    530                 535             


<210>  32
<211>  538
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GI.5) fusion VP1

<400>  32

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Gln Lys Thr 
    210                 215                 220                 


Arg Pro Phe Ser Val Pro Asn Ile Pro Leu Gln Leu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Val Pro Asn Leu Ile Gln Ser Met Val Leu Ser Pro Asp Gln Ala 
                245                 250                 255     


Gln Asn Val Gln Phe Gln Asn Gly Arg Cys Thr Thr Asp Gly Gln Leu 
            260                 265                 270         


Leu Gly Thr Thr Pro Val Ser Val Ser Gln Ile Leu Lys Phe Arg Gly 
        275                 280                 285             


Lys Val Ser Ala Gly Ser Lys Val Ile Asn Leu Thr Glu Leu Asp Gly 
    290                 295                 300                 


Ser Pro Phe Leu Ala Phe Glu Ala Pro Ala Pro Thr Gly Phe Pro Asp 
305                 310                 315                 320 


Leu Gly Thr Ser Asp Trp His Val Glu Met Ser Leu Asn Ser Asn Ser 
                325                 330                 335     


Gln Ser Ser Gly Asn Pro Ile Leu Leu Arg Asp Ile His Pro Asn Ser 
            340                 345                 350         


Ser Glu Phe Val Pro His Leu Gly Ser Val Cys Val Thr Ala Ala Ile 
        355                 360                 365             


Glu Val Ala Gly Asp Tyr Thr Gly Thr Ile Gln Trp Thr Ser Gln Pro 
    370                 375                 380                 


Ser Asn Val Thr Pro Val Pro Asp Val Asn Phe Trp Thr Ile Pro His 
385                 390                 395                 400 


Tyr Gly Ser Asn Leu Ala Glu Ala Ser Gln Leu Ala Pro Val Val Tyr 
                405                 410                 415     


Pro Pro Gly Phe Gly Glu Ala Ile Val Tyr Phe Met Ser Pro Ile Pro 
            420                 425                 430         


Gly Pro Asn Thr Ala His Lys Pro Asn Leu Val Pro Cys Leu Leu Pro 
        435                 440                 445             


Gln Glu Phe Val Thr His Phe Val Ser Glu Gln Ala Pro Ser Met Gly 
    450                 455                 460                 


Glu Ala Ala Leu Val His Tyr Val Asp Pro Asp Thr Asn Arg Asn Leu 
465                 470                 475                 480 


Gly Glu Phe Lys Leu Tyr Pro Glu Gly Phe Ile Thr Cys Val Pro Asn 
                485                 490                 495     


Gly Thr Gly Pro Gln Gln Leu Pro Leu Asn Gly Val Phe Val Phe Ala 
            500                 505                 510         


Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val Gly Thr Ala Ser 
        515                 520                 525             


Ser Ala Arg Gly Arg Leu Gly Val Arg Arg 
    530                 535             


<210>  33
<211>  535
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.1) fusion VP1

<400>  33

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Glu Leu Tyr Thr Ser Pro Asn Glu Gly 
                245                 250                 255     


Val Val Val Gln Pro Gln Asn Gly Arg Ser Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Val Pro Ser Asn Ile Cys Ala Leu Arg Gly 
        275                 280                 285             


Arg Ile Asn Ala Gln Val Pro Asp Asp His His Gln Trp Asn Leu Gln 
    290                 295                 300                 


Val Thr Asn Ala Asn Gly Thr Ser Phe Asp Pro Thr Glu Asp Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Thr Pro Asp Phe Leu Ala Asn Ile Tyr Gly Val Thr 
                325                 330                 335     


Ser Gln Arg Asn Pro Asp Asn Thr Cys Arg Ala His Asp Gly Val Leu 
            340                 345                 350         


Ala Thr Trp Ser Pro Lys Phe Thr Pro Lys Leu Gly Ser Val Val Leu 
        355                 360                 365             


Gly Thr Trp Glu Glu Ser Asp Leu Asp Leu Asn Gln Pro Thr Arg Phe 
    370                 375                 380                 


Thr Pro Val Gly Leu Tyr Asp Thr Gly His Phe Asp Gln Trp Val Leu 
385                 390                 395                 400 


Pro Asn Tyr Ser Gly Arg Leu Thr Leu Asn Met Asn Leu Ala Pro Ser 
                405                 410                 415     


Val Ala Pro Leu Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser His 
            420                 425                 430         


Ile Pro Leu Lys Gly Gly Thr Ser Asn Gly Ala Ile Asp Cys Leu Leu 
        435                 440                 445             


Pro Gln Glu Trp Ile Gln His Phe Tyr Gln Glu Ser Ala Pro Ser Pro 
    450                 455                 460                 


Thr Asp Val Ala Leu Ile Arg Tyr Thr Asn Pro Asp Thr Gly Arg Val 
465                 470                 475                 480 


Leu Phe Glu Ala Lys Leu His Arg Gln Gly Phe Ile Thr Val Ala Asn 
                485                 490                 495     


Ser Gly Ser Arg Pro Ile Val Val Pro Pro Asn Gly Tyr Phe Arg Phe 
            500                 505                 510         


Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Met Gly Thr Gly 
        515                 520                 525             


Asn Gly Arg Arg Arg Val Gln 
    530                 535 


<210>  34
<211>  542
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.2) fusion VP1

<400>  34

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Leu Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Ser Ile Asp Gln Met Tyr Thr Ser Pro Asn Glu Val 
                245                 250                 255     


Ile Ser Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Gln Val Ser Gly Ile Cys Ala Phe Lys Gly 
        275                 280                 285             


Glu Val Thr Ala His Leu His Asp Asn Asp His Leu Tyr Asn Val Thr 
    290                 295                 300                 


Ile Thr Asn Leu Asn Gly Ser Pro Phe Asp Pro Ser Glu Asp Ile Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Val Pro Asp Phe Gln Gly Arg Val Phe Gly Val Ile 
                325                 330                 335     


Ser Gln Arg Asp Lys His Asn Thr Pro Gly His Asn Glu Pro Ala Asn 
            340                 345                 350         


Arg Ala His Asp Ala Val Val Pro Thr Tyr Thr Ala Gln Tyr Thr Pro 
        355                 360                 365             


Lys Leu Gly Gln Ile Gln Ile Gly Thr Trp Gln Thr Asp Asp Leu Thr 
    370                 375                 380                 


Val Asn Gln Pro Val Lys Phe Thr Pro Val Gly Leu Asn Asp Thr Asp 
385                 390                 395                 400 


His Phe Asn Gln Trp Val Val Pro Arg Tyr Ala Gly Ala Leu Asn Leu 
                405                 410                 415     


Asn Thr Asn Leu Ala Pro Ser Val Ala Pro Val Phe Pro Gly Glu Arg 
            420                 425                 430         


Leu Leu Phe Phe Arg Ser Tyr Ile Pro Leu Lys Gly Gly Tyr Gly Thr 
        435                 440                 445             


Pro Ala Ile Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ser Met Ser Glu Val Ala Leu Val Arg Tyr Ile 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Ala Leu Phe Glu Ala Lys Leu His Arg Ala 
                485                 490                 495     


Gly Phe Met Thr Val Ser Ser Asn Thr Ser Ala Pro Val Val Val Pro 
            500                 505                 510         


Ala Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser 
        515                 520                 525             


Leu Ala Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Ile Gln 
    530                 535                 540         


<210>  35
<211>  548
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.3) fusion VP1

<400>  35

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Ser Leu Pro Ile Leu Thr Ile Ser Glu Met Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Ser Leu His Thr Ser Pro Thr Glu Asn 
                245                 250                 255     


Ile Val Val Gln Cys Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Met Gly Thr Thr Gln Leu Leu Pro Ser Gln Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Thr Leu Thr Arg Ser Thr Ser Arg Ala Ser Asp Gln Ala Asp Thr Ala 
    290                 295                 300                 


Thr Pro Arg Leu Phe Asn Tyr Tyr Trp His Ile Gln Leu Asp Asn Leu 
305                 310                 315                 320 


Asn Gly Thr Pro Tyr Asp Pro Ala Glu Asp Ile Pro Ala Pro Leu Gly 
                325                 330                 335     


Thr Pro Asp Phe Arg Gly Lys Val Phe Gly Val Ala Ser Gln Arg Asn 
            340                 345                 350         


Pro Asp Ala Thr Thr Arg Ala His Glu Ala Lys Ile Asp Thr Thr Ser 
        355                 360                 365             


Gly Arg Phe Thr Pro Lys Leu Gly Ser Leu Glu Ile Ser Thr Glu Ser 
    370                 375                 380                 


Gly Asp Phe Asp Gln Asn Gln Pro Thr Arg Phe Thr Pro Val Gly Ile 
385                 390                 395                 400 


Gly Val Asp His Glu Pro Asp Phe Gln Gln Trp Ala Leu Pro Asp Tyr 
                405                 410                 415     


Ala Gly Gln Phe Thr His Asn Met Asn Leu Ala Pro Ala Val Ala Pro 
            420                 425                 430         


Asn Phe Pro Gly Glu Gln Leu Leu Phe Phe Arg Ser Gln Leu Pro Ser 
        435                 440                 445             


Ser Gly Gly Arg Ser Asn Gly Ile Leu Asp Cys Leu Val Pro Gln Glu 
    450                 455                 460                 


Trp Val Gln His Phe Tyr Gln Glu Ser Ala Pro Ser Gln Thr Gln Val 
465                 470                 475                 480 


Ala Leu Val Arg Tyr Val Asn Pro Asp Thr Gly Arg Val Leu Phe Glu 
                485                 490                 495     


Ala Lys Leu His Lys Leu Arg Phe Met Thr Ile Ala Lys Ser Gly Asp 
            500                 505                 510         


Ser Pro Ile Thr Val Pro Pro Asn Gly Tyr Phe Arg Phe Glu Ser Trp 
        515                 520                 525             


Val Asn Pro Phe Tyr Thr Leu Ala Pro Met Gly Thr Gly Asn Gly Arg 
    530                 535                 540                 


Arg Arg Ile Gln 
545             


<210>  36
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.4) fusion VP1

<400>  36

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asp Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly Arg Val Gln Phe Glu 
        355                 360                 365             


Thr Asp Thr Asp Arg Asp Phe Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Gly Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Val 
    530                 535                 540 


<210>  37
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.5) fusion VP1

<400>  37

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Val Leu Thr Leu Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Leu Ser Ile Asp Glu Met Val Thr Ser Pro Asn Glu Ser 
                245                 250                 255     


Ile Val Val Gln Pro Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Gln Ala Cys Asn Ile Cys Ser Ile Arg Gly 
        275                 280                 285             


Lys Val Thr Gly Gln Val Pro Asn Glu Gln His Met Trp Asn Leu Glu 
    290                 295                 300                 


Ile Thr Asn Leu Asn Gly Thr Gln Phe Asp Pro Thr Asp Asp Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Val Pro Asp Phe Ala Gly Glu Val Phe Gly Val Leu 
                325                 330                 335     


Ser Gln Arg Asn Arg Gly Glu Ser Asn Pro Ala Asn Arg Ala His Asp 
            340                 345                 350         


Ala Val Val Ala Thr Tyr Ser Asp Lys Tyr Thr Pro Lys Leu Gly Leu 
        355                 360                 365             


Val Gln Ile Gly Thr Trp Asn Thr Asn Asp Val Glu Asn Gln Pro Thr 
    370                 375                 380                 


Lys Phe Thr Pro Ile Gly Leu Asn Glu Val Ala Asn Gly His Arg Phe 
385                 390                 395                 400 


Glu Gln Trp Thr Leu Pro Arg Tyr Ser Gly Ala Leu Thr Leu Asn Met 
                405                 410                 415     


Asn Leu Ala Pro Ala Val Ala Pro Leu Phe Pro Gly Glu Arg Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Tyr Val Pro Leu Lys Gly Gly Phe Gly Asn Pro Ala 
        435                 440                 445             


Ile Asp Cys Leu Val Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ser Ala Pro Ser Leu Gly Asp Val Ala Leu Val Arg Tyr Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Lys Gly Gly Phe 
                485                 490                 495     


Leu Thr Val Ser Ser Thr Ser Thr Gly Pro Val Val Val Pro Ala Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala 
        515                 520                 525             


Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Phe Gln 
    530                 535                 540 


<210>  38
<211>  548
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.6) fusion VP1

<400>  38

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Ser Leu Pro Ile Leu Thr Leu Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ala Pro Ile Asp Met Leu Tyr Thr Asp Pro Asn Glu Gly 
                245                 250                 255     


Ile Val Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Asp Gly Thr Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Val Pro Thr Gln Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Thr Leu Ile Gly Gln Thr Ser Arg Ser Pro Asp Ser Thr Asp Ser Ala 
    290                 295                 300                 


Pro Arg Arg Arg Asp His Pro Leu His Val Gln Leu Lys Asn Leu Asp 
305                 310                 315                 320 


Gly Thr Gln Tyr Asp Pro Thr Asp Glu Val Pro Ala Val Leu Gly Ala 
                325                 330                 335     


Ile Asp Phe Lys Gly Thr Val Phe Gly Val Ala Ser Gln Arg Asp Val 
            340                 345                 350         


Ser Gly Gln Gln Val Gly Ala Thr Arg Ala His Glu Val His Ile Asn 
        355                 360                 365             


Thr Thr Asp Pro Arg Tyr Thr Pro Lys Leu Gly Ser Ile Leu Met Tyr 
    370                 375                 380                 


Ser Glu Ser Asp Asp Phe Val Thr Gly Gln Pro Val Arg Phe Thr Pro 
385                 390                 395                 400 


Ile Gly Met Gly Asp Asn Asp Trp His Gln Trp Glu Leu Pro Asp Tyr 
                405                 410                 415     


Pro Gly His Leu Thr Leu Asn Met Asn Leu Ala Pro Ala Val Ala Pro 
            420                 425                 430         


Ala Phe Pro Gly Glu Arg Ile Leu Phe Phe Arg Ser Ile Val Pro Ser 
        435                 440                 445             


Ala Gly Gly Tyr Gly Ser Gly Gln Ile Asp Cys Leu Ile Pro Gln Glu 
    450                 455                 460                 


Trp Val Gln His Phe Tyr Gln Glu Ala Ala Pro Ser Gln Ser Ala Val 
465                 470                 475                 480 


Ala Leu Ile Arg Tyr Val Asn Pro Asp Thr Gly Arg Asn Ile Phe Glu 
                485                 490                 495     


Ala Lys Leu His Arg Glu Gly Phe Ile Thr Val Ala Asn Ser Gly Asn 
            500                 505                 510         


Asn Pro Ile Val Val Pro Pro Asn Gly Tyr Phe Arg Phe Glu Ala Trp 
        515                 520                 525             


Val Asn Gln Phe Tyr Thr Leu Thr Pro Met Gly Thr Gly Gln Gly Arg 
    530                 535                 540                 


Arg Arg Asp Gln 
545             


<210>  39
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.7) fusion VP1

<400>  39

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Gln Phe Thr Leu Pro Ile Leu Lys Ile Ser Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Val Glu Met Met Tyr Thr Ala Arg Asn Glu Asn 
                245                 250                 255     


Gln Val Val Gln Pro Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Pro Leu Leu Ala Val Asn Ile Cys Lys Phe Lys Gly 
        275                 280                 285             


Glu Val Ile Ala Lys Asn Gly Asp Val Arg Ser Tyr Arg Met Asp Met 
    290                 295                 300                 


Glu Ile Thr Asn Thr Asp Gly Thr Pro Ile Asp Pro Thr Glu Asp Thr 
305                 310                 315                 320 


Pro Gly Pro Ile Gly Ser Pro Asp Phe Gln Gly Ile Leu Phe Gly Val 
                325                 330                 335     


Ala Ser Gln Arg Asn Lys Asn Glu Gln Asn Pro Ala Thr Arg Ala His 
            340                 345                 350         


Glu Ala Asn Ile Asn Thr Gly Gly Asp Gln Tyr Ala Pro Lys Leu Ala 
        355                 360                 365             


Gln Val Lys Phe Phe Ser Glu Ser Gln Asp Phe Glu Val His Gln Pro 
    370                 375                 380                 


Thr Val Phe Thr Pro Val Gly Val Ala Gly Asp Thr Ser His Pro Phe 
385                 390                 395                 400 


Arg Gln Trp Val Leu Pro Arg Tyr Gly Gly His Leu Thr Asn Asn Thr 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Leu Phe Pro Gly Glu Gln Ile Leu 
            420                 425                 430         


Phe Phe Arg Ser Gln Ile Pro Ser Ser Gly Gly His Glu Leu Gly Tyr 
        435                 440                 445             


Met Asp Cys Leu Val Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Thr Ala Gln Ser Glu Val Ala Leu Ile Arg Phe Ile Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Lys Gln Gly Phe 
                485                 490                 495     


Ile Thr Val Ala His Thr Gly Asp Asn Pro Ile Val Met Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Glu Ala Trp Val Asn Gln Phe Tyr Ser Leu Ala 
        515                 520                 525             


Pro Val Gly Thr Gly Asn Gly Arg Arg Arg Ile Gln 
    530                 535                 540 


<210>  40
<211>  542
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.13) fusion VP1

<400>  40

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Ser Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Ser Ile Glu Gln Leu Tyr Thr Ala Pro Asn Glu Asn 
                245                 250                 255     


Asn Val Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Ser Ser Ala Val Cys Ser Tyr Arg Gly 
        275                 280                 285             


Arg Thr Val Ala Asn Ser Gly Asp Asn Trp Asp Gln Asn Val Leu Gln 
    290                 295                 300                 


Leu Thr Tyr Pro Ser Gly Ala Ser Tyr Asp Pro Thr Asp Glu Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Thr Gln Asp Phe Ser Gly Ile Leu Tyr Gly Val Leu 
                325                 330                 335     


Thr Gln Asp Asn Val Arg Glu Asn Thr Gly Glu Ala Lys Asn Ala Lys 
            340                 345                 350         


Gly Val Tyr Ile Ser Thr Thr Ser Gly Lys Phe Thr Pro Lys Ile Gly 
        355                 360                 365             


Ser Ile Gly Leu His Ser Ile Thr Glu Asp Val Arg Pro Asn Gln Gln 
    370                 375                 380                 


Ser Arg Phe Thr Pro Val Gly Val Ala Gln Asn Glu Asn Thr Pro Phe 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro His Tyr Ala Gly Ala Leu Ala Leu Asn Thr 
                405                 410                 415     


Asn Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Arg Val Pro Cys Val Gln Gly Leu Gln Gly Gln Asp 
        435                 440                 445             


Ala Phe Ile Asp Cys Leu Leu Pro Gln Glu Trp Val Asn His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ser Gln Ala Asp Val Ala Leu Ile Arg Tyr Val 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Thr Leu Phe Glu Ala Lys Leu His Arg Ser 
                485                 490                 495     


Gly Phe Ile Thr Val Ser His Thr Gly Ala Tyr Pro Leu Val Val Pro 
            500                 505                 510         


Pro Asn Gly His Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser 
        515                 520                 525             


Leu Ala Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Val Gln 
    530                 535                 540         


<210>  41
<211>  536
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.14) fusion VP1

<400>  41

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Asn Phe Thr Leu Pro Val Leu Arg Val Ser Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Val Leu Asp Gln Met Tyr Thr Ser Arg Asn Glu Asn 
                245                 250                 255     


Ile Ile Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Ile Leu Gln Ser Val Ser Ile Cys Asn Phe Lys Gly 
        275                 280                 285             


Thr Met Gln Ala Lys Leu Asn Glu Glu Pro Arg Tyr Gln Leu Gln Leu 
    290                 295                 300                 


Thr Asn Leu Asp Gly Ser Pro Ile Asp Pro Thr Asp Asp Met Pro Ala 
305                 310                 315                 320 


Pro Leu Gly Thr Pro Asp Phe Gln Ala Met Leu Tyr Gly Val Ala Ser 
                325                 330                 335     


Gln Arg Ser Ser Ile Asp Asn Ala Thr Arg Ala His Asp Ala Gln Ile 
            340                 345                 350         


Asp Thr Ala Gly Asp Thr Phe Ala Pro Lys Ile Gly Gln Val Arg Phe 
        355                 360                 365             


Lys Ser Ser Ser Asn Asp Phe Asp Leu His Asp Pro Thr Lys Phe Thr 
    370                 375                 380                 


Pro Ile Gly Val Asn Val Asp Asp Gln His Pro Phe Arg Gln Trp Ser 
385                 390                 395                 400 


Leu Pro Asn Tyr Gly Gly His Leu Ala Leu Asn Asn His Leu Ala Pro 
                405                 410                 415     


Ala Val Thr Pro Leu Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser 
            420                 425                 430         


Tyr Ile Pro Ser Ala Gly Gly His Thr Asp Gly Ala Met Asp Cys Leu 
        435                 440                 445             


Leu Pro Gln Glu Trp Val Glu His Phe Tyr Gln Glu Ala Ala Pro Ser 
    450                 455                 460                 


Gln Ser Asp Ile Ala Leu Val Arg Phe Ile Asn Pro Asp Thr Gly Arg 
465                 470                 475                 480 


Val Leu Phe Glu Ala Lys Leu His Lys Gln Gly Phe Leu Thr Ile Ala 
                485                 490                 495     


Ala Ser Gly Asp His Pro Ile Val Met Pro Thr Asn Gly Tyr Phe Arg 
            500                 505                 510         


Phe Glu Ala Trp Val Asn Pro Phe Tyr Thr Leu Ala Pro Val Gly Thr 
        515                 520                 525             


Gly Ser Gly Arg Arg Arg Ile Gln 
    530                 535     


<210>  42
<211>  538
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.17) fusion VP1

<400>  42

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Ser Leu Pro Ile Leu Thr Leu Ser Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Ser Leu Phe Thr Ala Gln Asn Asn Val 
                245                 250                 255     


Leu Gln Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Pro Ser Gly Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Arg Val Thr Ala Glu Thr Asp His Arg Asp Lys Trp His Met Gln Leu 
    290                 295                 300                 


Gln Asn Leu Asn Gly Thr Thr Tyr Asp Pro Thr Asp Asp Val Pro Ala 
305                 310                 315                 320 


Pro Leu Gly Thr Pro Asp Phe Lys Gly Val Val Phe Gly Val Ala Ser 
                325                 330                 335     


Gln Arg Asn Val Gly Asn Asp Ala Pro Gly Ser Thr Arg Ala His Glu 
            340                 345                 350         


Ala Val Ile Ser Thr Tyr Ser Pro Gln Phe Val Pro Lys Leu Gly Ser 
        355                 360                 365             


Val Asn Phe Arg Ser Asn Asp Asn Asp Phe Gln Leu Gln Pro Thr Lys 
    370                 375                 380                 


Phe Thr Pro Val Gly Ile Asn Asp Asp Gly Asp His Pro Phe Arg Gln 
385                 390                 395                 400 


Trp Glu Leu Pro Asp Tyr Ser Gly Leu Leu Thr Leu Asn Met Asn Leu 
                405                 410                 415     


Ala Pro Pro Val Ala Pro Asn Phe Pro Gly Glu Gln Leu Leu Phe Phe 
            420                 425                 430         


Arg Ser Phe Val Pro Cys Ser Gly Gly Tyr Asn Gln Gly Ile Val Asp 
        435                 440                 445             


Cys Leu Ile Pro Gln Glu Trp Ile Gln His Phe Tyr Gln Glu Ser Ala 
    450                 455                 460                 


Pro Ser Gln Ser Asp Val Ala Leu Ile Arg Tyr Val Asn Pro Asp Thr 
465                 470                 475                 480 


Gly Arg Thr Leu Phe Glu Ala Lys Leu His Arg Ser Gly Tyr Ile Thr 
                485                 490                 495     


Val Ala His Ser Gly Asp Tyr Pro Leu Val Val Pro Ala Asn Gly Tyr 
            500                 505                 510         


Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Met 
        515                 520                 525             


Gly Thr Gly Asn Gly Arg Arg Arg Ala Gln 
    530                 535             


<210>  43
<211>  539
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.12)+P(GII.21) fusion VP1

<400>  43

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Leu Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Ile Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Asn Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ala Pro Ile Asp Gln Leu Tyr Thr Ser Pro Asn Ala Asp 
                245                 250                 255     


Val Val Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Thr Thr Ala Ile Cys Ser Tyr Arg Gly 
        275                 280                 285             


Met Thr Ser Asn Pro Thr Ser Asp Tyr Trp Asp Asp His Leu Leu His 
    290                 295                 300                 


Leu Val His Pro Asn Gly Ala Thr Tyr Asp Pro Thr Glu Asp Val Pro 
305                 310                 315                 320 


Ala Pro Phe Gly Thr Gln Asp Phe Arg Gly Ile Leu Tyr Gly Met Leu 
                325                 330                 335     


Thr Gln Asn Pro Arg Thr Ser Gly Asp Glu Ala Ala Asn Ser His Gly 
            340                 345                 350         


Ile Tyr Ile Ser Ser Thr Ser Glu Lys Phe Thr Pro Lys Leu Gly Thr 
        355                 360                 365             


Ile Gly Leu His Gln Val Gln Gly Asp Ile Ala Ser Asn Gln Gln Ser 
    370                 375                 380                 


Lys Phe Thr Pro Val Gly Ile Ala Val Asn Gly Asn Thr Pro Phe Arg 
385                 390                 395                 400 


Gln Trp Glu Leu Pro Asn Tyr Ser Gly Ala Leu Thr Leu Asn Thr Asn 
                405                 410                 415     


Leu Ala Pro Ala Val Gly Pro Asn Phe Pro Gly Glu Gln Ile Leu Phe 
            420                 425                 430         


Phe Arg Ser Asn Val Pro Ser Val Gln Gly Gly Gln Pro Ile Glu Ile 
        435                 440                 445             


Asp Cys Leu Ile Pro Gln Glu Trp Val Ser His Phe Tyr Gln Glu Ser 
    450                 455                 460                 


Ala Pro Ser Gln Ser Asp Val Ala Leu Val Arg Tyr Val Asn Pro Asp 
465                 470                 475                 480 


Thr Gly Arg Thr Ile Phe Glu Ala Lys Leu His Arg Gln Gly Phe Ile 
                485                 490                 495     


Thr Ile Ala Ala Thr Gly Ser Asn Pro Val Val Val Pro Pro Asn Gly 
            500                 505                 510         


Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ala Leu Ala Pro 
        515                 520                 525             


Met Gly Thr Gly Asn Gly Arg Arg Arg Val Gln 
    530                 535                 


<210>  44
<211>  543
<212>  PRT
<213>  Norovirus GI.5/Siklos/Hun5407/2013/HUN

<400>  44

Met Met Met Ala Ser Lys Asp Ala Pro Ser Ser Ala Asp Gly Ala Asn 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Asn Ala Glu Pro Leu Pro 
            20                  25                  30          


Leu Asp Pro Val Ala Gly Ala Ser Thr Ala Leu Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Phe Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ala His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Ile 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Ile Ile Ala Asp Val Arg Thr Leu Glu Pro Ile Glu Ile 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Thr Leu Tyr His Thr Asn Asp Asn Gln 
                165                 170                 175     


Pro Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Thr Asp Ala Phe Val Val Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Ser Ser Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr 
    210                 215                 220                 


Val Glu Gln Lys Thr Arg Pro Phe Ser Val Pro Asn Ile Pro Leu Gln 
225                 230                 235                 240 


Leu Leu Ser Asn Ser Arg Val Pro Asn Leu Ile Gln Ser Met Val Leu 
                245                 250                 255     


Ser Pro Asp Gln Ala Gln Asn Val Gln Phe Gln Asn Gly Arg Cys Thr 
            260                 265                 270         


Thr Asp Gly Gln Leu Leu Gly Thr Thr Pro Val Ser Val Ser Gln Ile 
        275                 280                 285             


Leu Lys Phe Arg Gly Lys Val Ser Ala Gly Ser Lys Val Ile Asn Leu 
    290                 295                 300                 


Thr Glu Leu Asp Gly Ser Pro Phe Leu Ala Phe Glu Ala Pro Ala Pro 
305                 310                 315                 320 


Thr Gly Phe Pro Asp Leu Gly Thr Ser Asp Trp His Val Glu Met Ser 
                325                 330                 335     


Leu Asn Ser Asn Ser Gln Ser Ser Gly Asn Pro Ile Leu Leu Arg Asp 
            340                 345                 350         


Ile His Pro Asn Ser Ser Glu Phe Val Pro His Leu Gly Ser Val Cys 
        355                 360                 365             


Val Thr Ala Ala Ile Glu Val Ala Gly Asp Tyr Thr Gly Thr Ile Gln 
    370                 375                 380                 


Trp Thr Ser Gln Pro Ser Asn Val Thr Pro Val Pro Asp Val Asn Phe 
385                 390                 395                 400 


Trp Thr Ile Pro His Tyr Gly Ser Asn Leu Ala Glu Ala Ser Gln Leu 
                405                 410                 415     


Ala Pro Val Val Tyr Pro Pro Gly Phe Gly Glu Ala Ile Val Tyr Phe 
            420                 425                 430         


Met Ser Pro Ile Pro Gly Pro Asn Thr Ala His Lys Pro Asn Leu Val 
        435                 440                 445             


Pro Cys Leu Leu Pro Gln Glu Phe Val Thr His Phe Val Ser Glu Gln 
    450                 455                 460                 


Ala Pro Ser Met Gly Glu Ala Ala Leu Val His Tyr Val Asp Pro Asp 
465                 470                 475                 480 


Thr Asn Arg Asn Leu Gly Glu Phe Lys Leu Tyr Pro Glu Gly Phe Ile 
                485                 490                 495     


Thr Cys Val Pro Asn Gly Thr Gly Pro Gln Gln Leu Pro Leu Asn Gly 
            500                 505                 510         


Val Phe Val Phe Ala Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro 
        515                 520                 525             


Val Gly Thr Ala Ser Ser Ala Arg Gly Arg Leu Gly Val Arg Arg 
    530                 535                 540             


<210>  45
<211>  535
<212>  PRT
<213>  Norovirus GII.1/Ascension208/2010/USA

<400>  45

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Met Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Phe Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Ile Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Leu Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Pro Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Glu Leu Tyr Thr Ser Pro Asn Glu Gly 
                245                 250                 255     


Val Val Val Gln Pro Gln Asn Gly Arg Ser Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Val Pro Ser Asn Ile Cys Ala Leu Arg Gly 
        275                 280                 285             


Arg Ile Asn Ala Gln Val Pro Asp Asp His His Gln Trp Asn Leu Gln 
    290                 295                 300                 


Val Thr Asn Ala Asn Gly Thr Ser Phe Asp Pro Thr Glu Asp Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Thr Pro Asp Phe Leu Ala Asn Ile Tyr Gly Val Thr 
                325                 330                 335     


Ser Gln Arg Asn Pro Asp Asn Thr Cys Arg Ala His Asp Gly Val Leu 
            340                 345                 350         


Ala Thr Trp Ser Pro Lys Phe Thr Pro Lys Leu Gly Ser Val Val Leu 
        355                 360                 365             


Gly Thr Trp Glu Glu Ser Asp Leu Asp Leu Asn Gln Pro Thr Arg Phe 
    370                 375                 380                 


Thr Pro Val Gly Leu Tyr Asp Thr Gly His Phe Asp Gln Trp Val Leu 
385                 390                 395                 400 


Pro Asn Tyr Ser Gly Arg Leu Thr Leu Asn Met Asn Leu Ala Pro Ser 
                405                 410                 415     


Val Ala Pro Leu Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser His 
            420                 425                 430         


Ile Pro Leu Lys Gly Gly Thr Ser Asn Gly Ala Ile Asp Cys Leu Leu 
        435                 440                 445             


Pro Gln Glu Trp Ile Gln His Phe Tyr Gln Glu Ser Ala Pro Ser Pro 
    450                 455                 460                 


Thr Asp Val Ala Leu Ile Arg Tyr Thr Asn Pro Asp Thr Gly Arg Val 
465                 470                 475                 480 


Leu Phe Glu Ala Lys Leu His Arg Gln Gly Phe Ile Thr Val Ala Asn 
                485                 490                 495     


Ser Gly Ser Arg Pro Ile Val Val Pro Pro Asn Gly Tyr Phe Arg Phe 
            500                 505                 510         


Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Met Gly Thr Gly 
        515                 520                 525             


Asn Gly Arg Arg Arg Val Gln 
    530                 535 


<210>  46
<211>  536
<212>  PRT
<213>  Norovirus GII.14/8610/Saga/2008/JP

<400>  46

Met Lys Met Ala Ser Asn Asp Ala Thr Pro Ser Asp Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Val Val Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Ala Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Leu Leu Leu Asp Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly His Ala Gly Gly Met Glu Val Gln Ile Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Ile Pro Pro Ser Phe 
        115                 120                 125             


Pro Tyr Glu Asn Leu Ser Pro Ala Gln Leu Thr Met Cys Pro His Val 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 


Ile Arg Asn Val Phe Tyr His Tyr Asn Gln Asn Asn Ser Pro Lys Leu 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Gln Phe Thr Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Asn Phe Thr Leu Pro Val Leu Arg Val Ser Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Val Leu Asp Gln Met Tyr Thr Ser Arg Asn Glu Asn 
                245                 250                 255     


Ile Ile Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Ile Leu Gln Ser Val Ser Ile Cys Asn Phe Lys Gly 
        275                 280                 285             


Thr Met Gln Ala Lys Leu Asn Glu Glu Pro Arg Tyr Gln Leu Gln Leu 
    290                 295                 300                 


Thr Asn Leu Asp Gly Ser Pro Ile Asp Pro Thr Asp Asp Met Pro Ala 
305                 310                 315                 320 


Pro Leu Gly Thr Pro Asp Phe Gln Ala Met Leu Tyr Gly Val Ala Ser 
                325                 330                 335     


Gln Arg Ser Ser Ile Asp Asn Ala Thr Arg Ala His Asp Ala Gln Ile 
            340                 345                 350         


Asp Thr Ala Gly Asp Thr Phe Ala Pro Lys Ile Gly Gln Val Arg Phe 
        355                 360                 365             


Lys Ser Ser Ser Asn Asp Phe Asp Leu His Asp Pro Thr Lys Phe Thr 
    370                 375                 380                 


Pro Ile Gly Val Asn Val Asp Asp Gln His Pro Phe Arg Gln Trp Ser 
385                 390                 395                 400 


Leu Pro Asn Tyr Gly Gly His Leu Ala Leu Asn Asn His Leu Ala Pro 
                405                 410                 415     


Ala Val Thr Pro Leu Phe Pro Gly Glu Gln Ile Leu Phe Phe Arg Ser 
            420                 425                 430         


Tyr Ile Pro Ser Ala Gly Gly His Thr Asp Gly Ala Met Asp Cys Leu 
        435                 440                 445             


Leu Pro Gln Glu Trp Val Glu His Phe Tyr Gln Glu Ala Ala Pro Ser 
    450                 455                 460                 


Gln Ser Asp Ile Ala Leu Val Arg Phe Ile Asn Pro Asp Thr Gly Arg 
465                 470                 475                 480 


Val Leu Phe Glu Ala Lys Leu His Lys Gln Gly Phe Leu Thr Ile Ala 
                485                 490                 495     


Ala Ser Gly Asp His Pro Ile Val Met Pro Thr Asn Gly Tyr Phe Arg 
            500                 505                 510         


Phe Glu Ala Trp Val Asn Pro Phe Tyr Thr Leu Ala Pro Val Gly Thr 
        515                 520                 525             


Gly Ser Gly Arg Arg Arg Ile Gln 
    530                 535     


<210>  47
<211>  539
<212>  PRT
<213>  Norovirus GII.21/Salisbury150/2011/USA

<400>  47

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Thr 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Thr Glu Thr Leu Pro Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Ile Ala Ala Pro Val Thr Gly Gln Asn Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Met Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Val Asp Met Leu Ser Pro Ala Gln Ile Thr Met Leu Pro His Leu 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Ile Met Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Val Phe Tyr His Phe Asn Asn Gln Pro Ala Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             


Asp Phe Glu Phe Thr Tyr Leu Val Pro Pro Ser Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ala Pro Ile Asp Gln Leu Tyr Thr Ser Pro Asn Ala Asp 
                245                 250                 255     


Val Val Val Gln Pro Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Thr Thr Ala Ile Cys Ser Tyr Arg Gly 
        275                 280                 285             


Met Thr Ser Asn Pro Thr Ser Asp Tyr Trp Asp Asp His Leu Leu His 
    290                 295                 300                 


Leu Val His Pro Asn Gly Ala Thr Tyr Asp Pro Thr Glu Asp Val Pro 
305                 310                 315                 320 


Ala Pro Phe Gly Thr Gln Asp Phe Arg Gly Ile Leu Tyr Gly Met Leu 
                325                 330                 335     


Thr Gln Asn Pro Arg Thr Ser Gly Asp Glu Ala Ala Asn Ser His Gly 
            340                 345                 350         


Ile Tyr Ile Ser Ser Thr Ser Glu Lys Phe Thr Pro Lys Leu Gly Thr 
        355                 360                 365             


Ile Gly Leu His Gln Val Gln Gly Asp Ile Ala Ser Asn Gln Gln Ser 
    370                 375                 380                 


Lys Phe Thr Pro Val Gly Ile Ala Val Asn Gly Asn Thr Pro Phe Arg 
385                 390                 395                 400 


Gln Trp Glu Leu Pro Asn Tyr Ser Gly Ala Leu Thr Leu Asn Thr Asn 
                405                 410                 415     


Leu Ala Pro Ala Val Gly Pro Asn Phe Pro Gly Glu Gln Ile Leu Phe 
            420                 425                 430         


Phe Arg Ser Asn Val Pro Ser Val Gln Gly Gly Gln Pro Ile Glu Ile 
        435                 440                 445             


Asp Cys Leu Ile Pro Gln Glu Trp Val Ser His Phe Tyr Gln Glu Ser 
    450                 455                 460                 


Ala Pro Ser Gln Ser Asp Val Ala Leu Val Arg Tyr Val Asn Pro Asp 
465                 470                 475                 480 


Thr Gly Arg Thr Ile Phe Glu Ala Lys Leu His Arg Gln Gly Phe Ile 
                485                 490                 495     


Thr Ile Ala Ala Thr Gly Ser Asn Pro Val Val Val Pro Pro Asn Gly 
            500                 505                 510         


Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ala Leu Ala Pro 
        515                 520                 525             


Met Gly Thr Gly Asn Gly Arg Arg Arg Val Gln 
    530                 535                 


<210>  48
<211>  545
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GI.5)+P(GII.4) fusion VP1

<400>  48

Met Met Met Ala Ser Lys Asp Ala Pro Ser Ser Ala Asp Gly Ala Asn 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Asn Ala Glu Pro Leu Pro 
            20                  25                  30          


Leu Asp Pro Val Ala Gly Ala Ser Thr Ala Leu Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Met Ile Asp Pro Trp Ile Phe Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Ile Leu 
65                  70                  75                  80  


Phe Asp Leu Gln Leu Gly Pro His Leu Asn Pro Phe Leu Ala His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Val Ile 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Val Ile Ile Cys Cys Val 
        115                 120                 125             


Pro Pro Gly Phe Gln Ser Arg Thr Leu Ser Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Ile Ile Ala Asp Val Arg Thr Leu Glu Pro Ile Glu Ile 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Thr Leu Tyr His Thr Asn Asp Asn Gln 
                165                 170                 175     


Pro Thr Met Arg Leu Leu Cys Met Leu Tyr Thr Pro Leu Arg Thr Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Thr Asp Ala Phe Val Val Ala Gly Arg Val Leu 
        195                 200                 205             


Thr Cys Pro Ser Ser Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr 
    210                 215                 220                 


Val Glu Ser Arg Thr Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu 
225                 230                 235                 240 


Glu Met Thr Asn Ser Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr 
                245                 250                 255     


Gly Pro Ser Ser Ala Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr 
            260                 265                 270         


Thr Asp Gly Val Leu Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile 
        275                 280                 285             


Cys Thr Phe Arg Gly Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr 
    290                 295                 300                 


Thr Met Asn Leu Ala Ser Gln Asn Trp Asn Asp Tyr Asp Pro Thr Glu 
305                 310                 315                 320 


Glu Ile Pro Ala Pro Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln 
                325                 330                 335     


Gly Val Leu Thr Gln Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His 
            340                 345                 350         


Lys Ala Thr Val Tyr Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly 
        355                 360                 365             


Arg Val Gln Phe Glu Thr Asp Thr Asp Arg Asp Phe Glu Ala Asn Gln 
    370                 375                 380                 


Asn Thr Lys Phe Thr Pro Val Gly Val Ile Gln Asp Gly Gly Thr Thr 
385                 390                 395                 400 


His Arg Asn Glu Pro Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg 
                405                 410                 415     


Asn Thr His Asn Val His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro 
            420                 425                 430         


Gly Glu Gln Leu Leu Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly 
        435                 440                 445             


Tyr Pro Asn Met Asp Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln 
    450                 455                 460                 


Tyr Phe Tyr Gln Glu Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu 
465                 470                 475                 480 


Arg Phe Val Asn Pro Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu 
                485                 490                 495     


His Lys Ser Gly Tyr Val Thr Val Ala His Thr Gly Gln His Asp Leu 
            500                 505                 510         


Val Ile Pro Pro Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln 
        515                 520                 525             


Phe Tyr Thr Leu Ala Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala 
    530                 535                 540                 


Val 
545 


<210>  49
<211>  538
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.1)+P(GI.3) fusion VP1

<400>  49

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Met Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Phe Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Ile Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Leu Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Pro Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Gln Lys Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Asn Leu Pro Leu Asn Val Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Val Pro Ser Leu Ile Lys Ser Met Met Val Ser Gln Asp His Gly 
                245                 250                 255     


Gln Met Val Gln Phe Gln Asn Gly Arg Val Thr Leu Asp Gly Gln Leu 
            260                 265                 270         


Gln Gly Thr Thr Pro Thr Ser Ala Ser Gln Leu Cys Lys Ile Arg Gly 
        275                 280                 285             


Thr Val Tyr His Ala Thr Gly Gly Gln Gly Leu Asn Leu Thr Glu Ile 
    290                 295                 300                 


Asp Gly Thr Pro Tyr His Ala Phe Glu Ser Pro Ala Pro Ile Gly Phe 
305                 310                 315                 320 


Pro Asp Leu Gly Glu Cys Asp Trp His Ile Asn Ala Ser Pro Ala Asn 
                325                 330                 335     


Ala Phe Thr Asp Gly Ser Ile Ile His Arg Ile Asp Val Ala Gln Asp 
            340                 345                 350         


Ser Thr Phe Ala Pro His Leu Gly Thr Ile His Tyr Thr Asn Ala Asp 
        355                 360                 365             


Tyr Asn Ala Asn Val Gly Leu Ile Cys Ser Leu Glu Trp Leu Ser Pro 
    370                 375                 380                 


Pro Ser Gly Gly Ala Pro Lys Val Asn Pro Trp Ala Ile Pro Arg Tyr 
385                 390                 395                 400 


Gly Ser Thr Leu Thr Glu Ala Ala Gln Leu Ala Pro Pro Ile Tyr Pro 
                405                 410                 415     


Pro Gly Phe Gly Glu Ala Ile Val Phe Phe Met Ser Asp Phe Pro Ile 
            420                 425                 430         


Ala Asn Gly Ser Asp Gly Leu Ser Val Pro Cys Thr Ile Pro Gln Glu 
        435                 440                 445             


Phe Val Thr His Phe Val Asn Glu Gln Ala Pro Thr Arg Gly Glu Ala 
    450                 455                 460                 


Ala Leu Leu His Tyr Val Asp Pro Asp Thr His Arg Asn Leu Gly Glu 
465                 470                 475                 480 


Phe Lys Leu Tyr Pro Glu Gly Phe Met Thr Cys Val Pro Asn Ser Ser 
                485                 490                 495     


Gly Ser Gly Pro Gln Thr Leu Pro Ile Asn Gly Val Phe Thr Phe Ile 
            500                 505                 510         


Ser Trp Val Ser Arg Phe Tyr Gln Leu Lys Pro Val Gly Thr Thr Gly 
        515                 520                 525             


Pro Val Arg Arg Leu Gly Ile Arg Arg Ser 
    530                 535             


<210>  50
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.1)+P(GII.4) fusion VP1

<400>  50

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Met Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Phe Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Ile Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Leu Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Pro Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asp Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly Arg Val Gln Phe Glu 
        355                 360                 365             


Thr Asp Thr Asp Arg Asp Phe Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Gly Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Val 
    530                 535                 540 


<210>  51
<211>  538
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.1)+P(GII.17) fusion VP1

<400>  51

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Val Asn Asn Glu Thr Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Leu Thr Gly Gln Asn Asn Val Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Met Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Phe Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Ile Pro Pro His Phe 
        115                 120                 125             


Pro Leu Glu Asn Leu Ser Pro Gly Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gln Pro Glu Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Asn Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Ser Leu Pro Ile Leu Thr Leu Ser Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Ser Leu Phe Thr Ala Gln Asn Asn Val 
                245                 250                 255     


Leu Gln Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Pro Ser Gly Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Arg Val Thr Ala Glu Thr Asp His Arg Asp Lys Trp His Met Gln Leu 
    290                 295                 300                 


Gln Asn Leu Asn Gly Thr Thr Tyr Asp Pro Thr Asp Asp Val Pro Ala 
305                 310                 315                 320 


Pro Leu Gly Thr Pro Asp Phe Lys Gly Val Val Phe Gly Val Ala Ser 
                325                 330                 335     


Gln Arg Asn Val Gly Asn Asp Ala Pro Gly Ser Thr Arg Ala His Glu 
            340                 345                 350         


Ala Val Ile Ser Thr Tyr Ser Pro Gln Phe Val Pro Lys Leu Gly Ser 
        355                 360                 365             


Val Asn Phe Arg Ser Asn Asp Asn Asp Phe Gln Leu Gln Pro Thr Lys 
    370                 375                 380                 


Phe Thr Pro Val Gly Ile Asn Asp Asp Gly Asp His Pro Phe Arg Gln 
385                 390                 395                 400 


Trp Glu Leu Pro Asp Tyr Ser Gly Leu Leu Thr Leu Asn Met Asn Leu 
                405                 410                 415     


Ala Pro Pro Val Ala Pro Asn Phe Pro Gly Glu Gln Leu Leu Phe Phe 
            420                 425                 430         


Arg Ser Phe Val Pro Cys Ser Gly Gly Tyr Asn Gln Gly Ile Val Asp 
        435                 440                 445             


Cys Leu Ile Pro Gln Glu Trp Ile Gln His Phe Tyr Gln Glu Ser Ala 
    450                 455                 460                 


Pro Ser Gln Ser Asp Val Ala Leu Ile Arg Tyr Val Asn Pro Asp Thr 
465                 470                 475                 480 


Gly Arg Thr Leu Phe Glu Ala Lys Leu His Arg Ser Gly Tyr Ile Thr 
                485                 490                 495     


Val Ala His Ser Gly Asp Tyr Pro Leu Val Val Pro Ala Asn Gly Tyr 
            500                 505                 510         


Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro Met 
        515                 520                 525             


Gly Thr Gly Asn Gly Arg Arg Arg Ala Gln 
    530                 535             


<210>  52
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.14)+P(GII.4) fusion VP1

<400>  52

Met Lys Met Ala Ser Asn Asp Ala Thr Pro Ser Asp Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Ile Ala Ala Pro Val Val Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Ala Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Leu Leu Leu Asp Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly His Ala Gly Gly Met Glu Val Gln Ile Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Ile Pro Pro Ser Phe 
        115                 120                 125             


Pro Tyr Glu Asn Leu Ser Pro Ala Gln Leu Thr Met Cys Pro His Val 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 


Ile Arg Asn Val Phe Tyr His Tyr Asn Gln Asn Asn Ser Pro Lys Leu 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Gln Phe Thr Phe Leu Val Pro Pro Thr Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asp Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly Arg Val Gln Phe Glu 
        355                 360                 365             


Thr Asp Thr Asp Arg Asp Phe Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Gly Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Val 
    530                 535                 540 


<210>  53
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GII.21)+P(GII.4) fusion VP1

<400>  53

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Thr 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Thr Glu Thr Leu Pro Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Ile Ala Ala Pro Val Thr Gly Gln Asn Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Met Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Val Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Leu Phe Ala Ala Val Pro Pro Asn Phe 
        115                 120                 125             


Pro Val Asp Met Leu Ser Pro Ala Gln Ile Thr Met Leu Pro His Leu 
    130                 135                 140                 


Ile Val Asp Val Arg Thr Leu Glu Pro Ile Met Ile Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Val Phe Tyr His Phe Asn Asn Gln Pro Ala Pro Arg Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             


Asp Phe Glu Phe Thr Tyr Leu Val Pro Pro Ser Val Glu Ser Arg Thr 
    210                 215                 220                 


Lys Pro Phe Ser Val Pro Val Leu Thr Val Glu Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Ile Pro Leu Glu Lys Leu Phe Thr Gly Pro Ser Ser Ala 
                245                 250                 255     


Phe Val Val Gln Pro Gln Asn Gly Arg Cys Thr Thr Asp Gly Val Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Ser Pro Val Asn Ile Cys Thr Phe Arg Gly 
        275                 280                 285             


Asp Val Thr His Ile Thr Gly Ser Arg Asn Tyr Thr Met Asn Leu Ala 
    290                 295                 300                 


Ser Gln Asn Trp Asn Asp Tyr Asp Pro Thr Glu Glu Ile Pro Ala Pro 
305                 310                 315                 320 


Leu Gly Thr Pro Asp Phe Val Gly Lys Ile Gln Gly Val Leu Thr Gln 
                325                 330                 335     


Thr Thr Arg Thr Asp Gly Ser Thr Arg Gly His Lys Ala Thr Val Tyr 
            340                 345                 350         


Thr Gly Ser Ala Asp Phe Ala Pro Lys Leu Gly Arg Val Gln Phe Glu 
        355                 360                 365             


Thr Asp Thr Asp Arg Asp Phe Glu Ala Asn Gln Asn Thr Lys Phe Thr 
    370                 375                 380                 


Pro Val Gly Val Ile Gln Asp Gly Gly Thr Thr His Arg Asn Glu Pro 
385                 390                 395                 400 


Gln Gln Trp Val Leu Pro Ser Tyr Ser Gly Arg Asn Thr His Asn Val 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Thr Phe Pro Gly Glu Gln Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Thr Met Pro Gly Cys Ser Gly Tyr Pro Asn Met Asp 
        435                 440                 445             


Leu Asp Cys Leu Leu Pro Gln Glu Trp Val Gln Tyr Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Pro Ala Gln Ser Asp Val Ala Leu Leu Arg Phe Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Cys Lys Leu His Lys Ser Gly Tyr 
                485                 490                 495     


Val Thr Val Ala His Thr Gly Gln His Asp Leu Val Ile Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Thr Leu Ala 
        515                 520                 525             


Pro Met Gly Asn Gly Thr Gly Arg Arg Arg Ala Val 
    530                 535                 540 


<210>  54
<211>  1641
<212>  PRT
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP1 
       G1.2_Leuven_2003_D2DEL3

<400>  54

Ala Thr Gly Ala Thr Gly Ala Thr Gly Gly Cys Thr Thr Cys Ala Ala 
1               5                   10                  15      


Ala Gly Gly Ala Thr Gly Cys Thr Cys Cys Cys Cys Ala Ala Ala Gly 
            20                  25                  30          


Cys Gly Cys Gly Gly Ala Cys Gly Gly Ala Gly Cys Thr Ala Gly Cys 
        35                  40                  45              


Gly Gly Cys Gly Cys Cys Gly Gly Ala Cys Ala Gly Thr Thr Gly Gly 
    50                  55                  60                  


Thr Thr Cys Cys Gly Gly Ala Ala Gly Thr Cys Ala Ala Cys Ala Cys 
65                  70                  75                  80  


Thr Gly Cys Cys Gly Ala Thr Cys Cys Ala Cys Thr Gly Cys Cys Cys 
                85                  90                  95      


Ala Thr Gly Gly Ala Ala Cys Cys Cys Gly Thr Ala Gly Cys Thr Gly 
            100                 105                 110         


Gly Thr Cys Cys Ala Ala Cys Ala Ala Cys Cys Gly Cys Thr Gly Thr 
        115                 120                 125             


Thr Gly Cys Cys Ala Cys Cys Gly Cys Cys Gly Gly Cys Cys Ala Gly 
    130                 135                 140                 


Gly Thr Thr Ala Ala Cys Ala Thr Gly Ala Thr Cys Gly Ala Thr Cys 
145                 150                 155                 160 


Cys Ala Thr Gly Gly Ala Thr Thr Gly Thr Thr Ala Ala Thr Ala Ala 
                165                 170                 175     


Cys Thr Thr Thr Gly Thr Ala Cys Ala Gly Ala Gly Cys Cys Cys Cys 
            180                 185                 190         


Cys Ala Gly Gly Gly Gly Gly Ala Gly Thr Thr Cys Ala Cys Ala Ala 
        195                 200                 205             


Thr Thr Thr Cys Thr Cys Cys Gly Ala Ala Cys Ala Ala Thr Ala Cys 
    210                 215                 220                 


Cys Cys Cys Thr Gly Gly Gly Gly Ala Cys Ala Thr Thr Cys Thr Gly 
225                 230                 235                 240 


Thr Thr Cys Gly Ala Thr Cys Thr Gly Cys Ala Ala Cys Thr Gly Gly 
                245                 250                 255     


Gly Cys Cys Cys Ala Cys Ala Cys Thr Thr Gly Ala Ala Thr Cys Cys 
            260                 265                 270         


Thr Thr Thr Cys Cys Thr Gly Ala Gly Cys Cys Ala Thr Cys Thr Thr 
        275                 280                 285             


Thr Cys Ala Cys Ala Gly Ala Thr Gly Thr Ala Cys Ala Ala Cys Gly 
    290                 295                 300                 


Gly Ala Thr Gly Gly Gly Thr Thr Gly Gly Gly Ala Ala Cys Ala Thr 
305                 310                 315                 320 


Gly Cys Gly Thr Gly Thr Thr Cys Gly Gly Ala Thr Cys Cys Thr Cys 
                325                 330                 335     


Cys Thr Thr Gly Cys Thr Gly Gly Cys Ala Ala Cys Gly Cys Cys Thr 
            340                 345                 350         


Thr Cys Ala Gly Thr Gly Cys Thr Gly Gly Cys Ala Ala Gly Ala Thr 
        355                 360                 365             


Thr Ala Thr Cys Gly Thr Gly Thr Gly Cys Thr Gly Cys Gly Thr Ala 
    370                 375                 380                 


Cys Cys Ala Cys Cys Ala Gly Gly Gly Thr Thr Thr Ala Cys Cys Thr 
385                 390                 395                 400 


Cys Gly Ala Gly Thr Thr Cys Ala Thr Thr Ala Ala Cys Cys Ala Thr 
                405                 410                 415     


Thr Gly Cys Thr Cys Ala Gly Gly Cys Cys Ala Cys Cys Cys Thr Thr 
            420                 425                 430         


Thr Thr Cys Cys Cys Thr Cys Ala Cys Gly Thr Gly Ala Thr Cys Gly 
        435                 440                 445             


Cys Ala Gly Ala Cys Gly Thr Gly Cys Gly Thr Ala Cys Cys Thr Thr 
    450                 455                 460                 


Ala Gly Ala Ala Cys Cys Ala Ala Thr Cys Gly Ala Ala Ala Thr Gly 
465                 470                 475                 480 


Cys Cys Cys Cys Thr Gly Gly Ala Ala Gly Ala Thr Gly Thr Ala Cys 
                485                 490                 495     


Gly Gly Ala Ala Cys Gly Thr Gly Cys Thr Gly Thr Ala Cys Cys Ala 
            500                 505                 510         


Thr Ala Cys Thr Ala Ala Thr Gly Ala Thr Ala Ala Cys Cys Ala Gly 
        515                 520                 525             


Cys Cys Ala Ala Cys Gly Ala Thr Gly Ala Gly Ala Thr Thr Ala Gly 
    530                 535                 540                 


Thr Gly Thr Gly Cys Ala Thr Gly Cys Thr Gly Thr Ala Cys Ala Cys 
545                 550                 555                 560 


Cys Cys Cys Cys Cys Thr Gly Ala Gly Ala Ala Cys Thr Gly Gly Ala 
                565                 570                 575     


Gly Gly Ala Gly Gly Thr Thr Cys Thr Gly Gly Ala Ala Ala Thr Thr 
            580                 585                 590         


Cys Cys Gly Ala Cys Ala Gly Thr Thr Thr Thr Gly Thr Gly Gly Thr 
        595                 600                 605             


Gly Gly Cys Thr Gly Gly Cys Ala Gly Gly Gly Thr Cys Cys Thr Gly 
    610                 615                 620                 


Ala Cys Cys Gly Cys Thr Cys Cys Cys Ala Gly Thr Ala Gly Cys Gly 
625                 630                 635                 640 


Ala Cys Thr Thr Cys Ala Gly Cys Thr Thr Thr Thr Thr Gly Thr Thr 
                645                 650                 655     


Cys Cys Thr Cys Gly Thr Thr Cys Cys Thr Cys Cys Thr Ala Cys Ala 
            660                 665                 670         


Ala Thr Cys Gly Ala Ala Cys Ala Ala Ala Ala Ala Ala Cys Ala Ala 
        675                 680                 685             


Gly Ala Gly Cys Ala Thr Thr Cys Ala Cys Ala Gly Thr Gly Cys Cys 
    690                 695                 700                 


Cys Ala Ala Cys Ala Thr Thr Cys Cys Ala Cys Thr Gly Cys Ala Gly 
705                 710                 715                 720 


Ala Cys Thr Thr Thr Ala Ala Gly Cys Ala Ala Thr Thr Cys Cys Ala 
                725                 730                 735     


Gly Gly Thr Thr Thr Cys Cys Cys Ala Gly Cys Thr Thr Gly Ala Thr 
            740                 745                 750         


Cys Cys Ala Gly Gly Gly Thr Ala Thr Gly Ala Thr Cys Cys Thr Thr 
        755                 760                 765             


Thr Cys Thr Cys Cys Cys Gly Ala Cys Gly Cys Cys Thr Cys Cys Cys 
    770                 775                 780                 


Ala Ala Gly Thr Thr Gly Thr Gly Cys Ala Gly Thr Thr Cys Cys Ala 
785                 790                 795                 800 


Gly Ala Ala Thr Gly Gly Gly Ala Gly Ala Thr Gly Thr Cys Thr Thr 
                805                 810                 815     


Ala Thr Cys Gly Ala Cys Gly Gly Thr Cys Ala Gly Cys Thr Thr Cys 
            820                 825                 830         


Thr Gly Gly Gly Ala Ala Cys Ala Ala Cys Cys Cys Cys Thr Gly Cys 
        835                 840                 845             


Cys Ala Cys Cys Thr Cys Cys Gly Gly Gly Cys Ala Ala Cys Thr Cys 
    850                 855                 860                 


Thr Thr Cys Cys Gly Gly Gly Thr Gly Ala Gly Ala Gly Gly Cys Ala 
865                 870                 875                 880 


Ala Ala Ala Thr Cys Ala Ala Thr Cys Ala Gly Gly Gly Cys Gly Cys 
                885                 890                 895     


Cys Ala Gly Ala Ala Cys Ala Cys Thr Gly Ala Ala Thr Cys Thr Gly 
            900                 905                 910         


Ala Cys Ala Gly Ala Ala Gly Thr Gly Gly Ala Cys Gly Gly Gly Ala 
        915                 920                 925             


Ala Ala Cys Cys Cys Thr Thr Thr Ala Thr Gly Gly Cys Gly Thr Thr 
    930                 935                 940                 


Cys Gly Ala Thr Ala Gly Cys Cys Cys Cys Gly Cys Gly Cys Cys Cys 
945                 950                 955                 960 


Gly Thr Thr Gly Gly Ala Thr Thr Cys Cys Cys Thr Gly Ala Cys Thr 
                965                 970                 975     


Thr Cys Gly Gly Cys Ala Ala Gly Thr Gly Thr Gly Ala Thr Thr Gly 
            980                 985                 990         


Gly Cys Ala Cys Ala Thr Gly Cys  Gly Cys Ala Thr Cys  Ala Gly Thr 
        995                 1000                 1005             


Ala Ala  Gly Ala Cys Thr Cys  Cys Cys Ala Ala Cys  Ala Ala Cys 
    1010                 1015                 1020             


Ala Cys  Thr Thr Cys Ala Thr  Cys Thr Gly Gly Ala  Gly Ala Cys 
    1025                 1030                 1035             


Cys Cys  Cys Ala Thr Gly Ala  Gly Gly Ala Gly Cys  Gly Thr Gly 
    1040                 1045                 1050             


Gly Ala  Thr Gly Thr Cys Cys  Ala Gly Ala Cys Cys  Gly Ala Cys 
    1055                 1060                 1065             


Gly Thr  Gly Cys Ala Gly Gly  Gly Cys Thr Thr Cys  Gly Thr Gly 
    1070                 1075                 1080             


Cys Cys  Gly Cys Ala Cys Thr  Thr Gly Gly Gly Ala  Thr Cys Thr 
    1085                 1090                 1095             


Ala Thr  Cys Cys Ala Gly Thr  Thr Cys Gly Ala Thr  Gly Ala Gly 
    1100                 1105                 1110             


Gly Thr  Gly Thr Thr Cys Ala  Ala Thr Cys Ala Cys  Cys Cys Thr 
    1115                 1120                 1125             


Ala Cys  Thr Gly Gly Cys Gly  Ala Cys Thr Ala Cys  Ala Thr Ala 
    1130                 1135                 1140             


Gly Gly  Cys Ala Cys Ala Ala  Thr Thr Gly Ala Gly  Thr Gly Gly 
    1145                 1150                 1155             


Ala Thr  Ala Ala Gly Thr Cys  Ala Ala Cys Cys Ala  Thr Cys Thr 
    1160                 1165                 1170             


Ala Cys  Ala Cys Cys Thr Cys  Cys Ala Gly Gly Gly  Ala Cys Cys 
    1175                 1180                 1185             


Gly Ala  Cys Ala Thr Ala Ala  Ala Cys Cys Thr Gly  Thr Gly Gly 
    1190                 1195                 1200             


Gly Ala  Ala Ala Thr Thr Cys  Cys Thr Gly Ala Thr  Thr Ala Cys 
    1205                 1210                 1215             


Gly Gly  Gly Thr Cys Ala Thr  Cys Cys Cys Thr Gly  Ala Gly Thr 
    1220                 1225                 1230             


Cys Ala  Ala Gly Cys Thr Gly  Cys Cys Ala Ala Thr  Cys Thr Thr 
    1235                 1240                 1245             


Gly Cys  Ala Cys Cys Cys Cys  Cys Thr Gly Thr Cys  Thr Thr Thr 
    1250                 1255                 1260             


Cys Cys  Cys Cys Cys Cys Gly  Gly Cys Thr Thr Thr  Gly Gly Thr 
    1265                 1270                 1275             


Gly Ala  Gly Gly Cys Thr Cys  Thr Thr Gly Thr Thr  Thr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Cys Gly Thr Cys Thr  Cys Thr Gly Cys Ala  Thr Thr Thr 
    1295                 1300                 1305             


Cys Cys  Thr Gly Gly Thr Cys  Cys Thr Ala Ala Cys  Ala Ala Cys 
    1310                 1315                 1320             


Cys Gly  Cys Thr Cys Cys Gly  Cys Cys Cys Cys Thr  Ala Ala Cys 
    1325                 1330                 1335             


Gly Ala  Thr Gly Thr Thr Cys  Cys Gly Thr Gly Thr  Thr Thr Gly 
    1340                 1345                 1350             


Thr Thr  Ala Cys Cys Cys Cys  Ala Gly Gly Ala Ala  Thr Ala Thr 
    1355                 1360                 1365             


Gly Thr  Gly Ala Cys Thr Cys  Ala Thr Thr Thr Cys  Gly Thr Thr 
    1370                 1375                 1380             


Thr Cys  Cys Gly Ala Ala Cys  Ala Gly Gly Cys Ala  Cys Cys Cys 
    1385                 1390                 1395             


Ala Cys  Cys Ala Thr Gly Gly  Gly Gly Gly Ala Cys  Gly Cys Thr 
    1400                 1405                 1410             


Gly Cys  Cys Cys Thr Gly Cys  Thr Ala Cys Ala Cys  Thr Ala Thr 
    1415                 1420                 1425             


Gly Thr  Gly Gly Ala Cys Cys  Cys Cys Gly Ala Cys  Ala Cys Cys 
    1430                 1435                 1440             


Ala Ala  Thr Ala Gly Ala Ala  Ala Cys Cys Thr Cys  Gly Gly Cys 
    1445                 1450                 1455             


Gly Ala  Gly Thr Thr Cys Ala  Ala Ala Cys Thr Cys  Thr Ala Cys 
    1460                 1465                 1470             


Cys Cys  Cys Gly Gly Gly Gly  Gly Ala Thr Ala Cys  Cys Thr Gly 
    1475                 1480                 1485             


Ala Cys  Cys Thr Gly Thr Gly  Thr Thr Cys Cys Ala  Ala Ala Thr 
    1490                 1495                 1500             


Gly Gly  Ala Gly Thr Gly Gly  Gly Ala Gly Cys Ala  Gly Gly Cys 
    1505                 1510                 1515             


Cys Cys  Ala Cys Ala Ala Cys  Ala Gly Cys Thr Gly  Cys Cys Cys 
    1520                 1525                 1530             


Cys Thr  Gly Ala Ala Thr Gly  Gly Gly Gly Thr Cys  Thr Thr Cys 
    1535                 1540                 1545             


Cys Thr  Gly Thr Thr Cys Gly  Thr Thr Thr Cys Thr  Thr Gly Gly 
    1550                 1555                 1560             


Gly Thr  Gly Thr Cys Ala Cys  Gly Cys Thr Thr Thr  Thr Ala Cys 
    1565                 1570                 1575             


Cys Ala  Gly Cys Thr Gly Ala  Ala Gly Cys Cys Cys  Gly Thr Thr 
    1580                 1585                 1590             


Gly Gly  Cys Ala Cys Ala Gly  Cys Thr Thr Cys Thr  Ala Cys Gly 
    1595                 1600                 1605             


Gly Cys  Ala Cys Gly Cys Gly  Gly Cys Ala Gly Gly  Cys Thr Ala 
    1610                 1615                 1620             


Gly Gly  Gly Gly Thr Cys Cys  Gly Cys Cys Gly Ala  Ala Thr Cys 
    1625                 1630                 1635             


Thr Gly  Ala 
    1640     


<210>  55
<211>  1632
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP1 
       GI.3_LillaEdet_2008_H2DG70

<400>  55
atgatgatgg cttccaagga tgctcccaca aacatggatg gaacaagcgg cgcggggcaa       60

cttgtgccgg aggtgtccac ggcggaaccc atttccatgg aacctgtggc cggcgcagcc      120

actgctgccg ccaccgcagg acaggtaaac atgatcgacc cctggatcat gtcaaattac      180

gttcaggctc cacaggggga gtttaccata agcccaaaca acaccccggg tgacatcttg      240

tttgacctgc agctaggacc acacttgaat ccgtttctga gtcacttggc tcagatgtat      300

aatggatggg ttggaaacat gaaggtgcgc gtgctcctgg cgggcaatgc attcacagcc      360

gggaagatta ttatctcttg cgtgccacct ggatttgcag cccagaacgt gtctatcgca      420

caggcaacca tgtttccgca tgtcatcgca gatgtgcgcg tgctagagcc catcgaggtg      480

ccccttgagg acgtgcgcaa cgtcctattc cataacaatg atagcacccc caccatgcgc      540

ttgatatgta tgttatatac tcccctccgc gccagtgggt ccagctccgg gaccgatcct      600

tttgtgattg ctgggcgggt gttgacttgt cctagccctg acttcaactt cctttttctg      660

gtgcctccaa atgtagaaca gaaaacaaag ccattcagcg tgccaaacct gccccttaac      720

gtgctgtcga attcccgagt gccttccctt attaagtcca tgatggtatc tcaggatcac      780

ggtcaaatgg tgcagtttca gaacggccga gtgacgttag acgggcagct gcagggcaca      840

accccaacca gtgccagtca gctgtgtaag atcagaggca ccgtctacca cgcaactggc      900

ggacaggggc tgaatcttac tgagatcgat ggtaccccct accatgcatt cgagtcacct      960

gcacctattg gatttcccga tcttggggag tgtgattggc atatcaatgc ttcacctgcc     1020

aacgctttca cagacgggtc tattattcat cgcattgacg tagcacagga tagcacattt     1080

gccccgcacc tgggtaccat ccactatacg aacgcagatt acaacgcaaa cgtgggtctt     1140

atctgtagcc tagagtggct atctccgcca agcggtgggg cccctaaagt taacccatgg     1200

gctattcctc ggtacgggtc tacgctgact gaggccgctc agctggcacc ccccatatat     1260

ccaccaggat tcggggaagc cattgttttc tttatgtccg attttccgat agccaacggt     1320

tcagatggcc ttagtgtccc ttgcacgatt ccacaggaat ttgtgacaca cttcgtaaac     1380

gagcaggctc ctactcgggg cgaggctgcc ttgttgcatt acgtagaccc cgatacccat     1440

agaaacctgg gcgaattcaa actctaccct gaaggtttca tgacctgcgt acctaactcc     1500

tccggcagtg gccctcaaac cttgccgatc aacggcgtgt tcacgtttat cagctgggtt     1560

tcacggtttt accaactcaa gcccgtcgga acaactgggc cagttcggag gctcgggatc     1620

agacggagct ag                                                         1632


<210>  56
<211>  1623
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP1 
       GII.4_Sydney_2012_K4LM89

<400>  56
atgaaaatgg cctcgagtga cgctaaccct agtgacggca gcgccgccaa tcttgtgcct       60

gaggttaata atgaggtgat ggccctggag cctgtggtgg gcgcagccat agcagcgccc      120

gtggccggtc agcagaatgt gattgacccg tggatacgca acaattttgt ccaagcccct      180

ggtggggagt tcaccgttag cccgagaaat gcgccaggag aaatcctgtg gtcggcccca      240

ttgggacccg atctgaaccc ctatttgtca catctcgctc ggatgtacaa cgggtatgcc      300

ggcggatttg aagtgcaggt gattctggct gggaacgcgt tcactgctgg caaagtgatc      360

tttgcagcgg tgcctcccaa cttccccact gaaggactgt ctccaagcca ggtcacaatg      420

tttccacaca tcgtggtgga cgtacggcag ctagagcctg tcctgattcc cctccctgat      480

gtacgcaata atttctacca ctacaatcaa tccaatgatc cgaccattaa actcatcgcg      540

atgttgtaca cccctctgcg cgctaacaat gctggagacg acgtattcac cgtgtcatgc      600

agagtgctca ccagaccttc accagacttt gactttatct tcttagtgcc ccccactgtt      660

gagagccgaa ccaagccctt tagtgtcccc gtactcacag tcgaggagat gacaaatagc      720

cgctttccaa tcccccttga gaaactgttc acaggacctt cctcggcatt cgtggttcag      780

ccacagaacg gacgctgcac aactgacggc gtgctgctcg gaaccaccca gcttagccct      840

gttaatatct gtacgtttag aggcgacgta actcacataa ctggctcacg gaactatacc      900

atgaatctgg catcacagaa ttggaatgac tacgacccaa ccgaagagat tcccgcacct      960

cttggaaccc ccgactttgt gggaaaaata cagggcgtcc tgacacaaac caccagaacc     1020

gatggctcca cacggggaca caaggcaacc gtctacactg gctctgccga ttttgccccg     1080

aaactgggta gagtgcagtt tgagaccgac actgaccggg actttgaagc caatcagaat     1140

actaagttca cacctgtagg agtgattcag gacgggggca ccactcaccg gaacgagccg     1200

caacaatggg tcctgccctc ttatagcggg aggaatactc ataatgtgca tttggctcct     1260

gcagtggctc ccacgtttcc cggggaacaa ctgctctttt ttcgttcaac catgcctgga     1320

tgctccggat atcccaatat ggatctcgat tgcctgctcc cacaggaatg ggtgcagtat     1380

ttttatcaag aggccgcacc agcccaatcc gacgtcgcac ttctgcggtt cgtgaatcca     1440

gacacaggcc gcgtgttgtt tgagtgcaaa ttgcacaaat caggatacgt tacagtggct     1500

catactggac agcatgacct ggtgatccca cccaacggat attttaggtt cgactcctgg     1560

gtgaatcagt tttatacatt agcccccatg gggaatggga ctggcagacg cagggctgtc     1620

tga                                                                   1623


<210>  57
<211>  1638
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon optimized S(GI.1)+P(GI.2) 
       fusion VP1

<400>  57
atgatgatgg ctagtaaaga tgcgacctcc tctgtggatg gtgcgtcagg ggcaggacaa       60

ctcgtacccg aggtaaacgc cagcgaccca cttgccatgg accccgttgc cggaagttcc      120

acagcagtgg ccacagccgg tcaagtgaat ccaattgatc cgtggattat caacaatttc      180

gtccaggcac cccagggcga gttcacaatt tcaccaaaca atacaccggg cgatgtgcta      240

ttcgatcttt ccttgggtcc tcaccttaac ccttttctac tccatctctc acagatgtac      300

aatggttggg taggaaacat gagagtccgg atcatgctgg ctggcaatgc ctttaccgct      360

ggcaagatca tcgtcagttg tattcctccc ggatttggat ctcataatct gaccattgct      420

caagcgactc tctttcccca tgtcatcgcc gacgttagga ccctggaccc catcgaggtg      480

cccctggagg acgtccggaa tgttttgttc cacaacaacg acagaaacca gcagacgatg      540

agacttgtct gtatgctcta taccccactg cggactggag gcgggactgg agactccttc      600

gttgtggcag gaagagtgat gacatgcccc tcccccgact tcaactttct ttttctggtc      660

ccaccaaccg ttgagcaaaa aacaagagca ttcacagtgc ccaacattcc actgcagact      720

ttaagcaatt ccaggtttcc cagcttgatc cagggtatga tcctttctcc cgacgcctcc      780

caagttgtgc agttccagaa tgggagatgt cttatcgacg gtcagcttct gggaacaacc      840

cctgccacct ccgggcaact cttccgggtg agaggcaaaa tcaatcaggg cgccagaaca      900

ctgaatctga cagaagtgga cgggaaaccc tttatggcgt tcgatagccc cgcgcccgtt      960

ggattccctg acttcggcaa gtgtgattgg cacatgcgca tcagtaagac tcccaacaac     1020

acttcatctg gagaccccat gaggagcgtg gatgtccaga ccgacgtgca gggcttcgtg     1080

ccgcacttgg gatctatcca gttcgatgag gtgttcaatc accctactgg cgactacata     1140

ggcacaattg agtggataag tcaaccatct acacctccag ggaccgacat aaacctgtgg     1200

gaaattcctg attacgggtc atccctgagt caagctgcca atcttgcacc ccctgtcttt     1260

ccccccggct ttggtgaggc tcttgtttac ttcgtctctg catttcctgg tcctaacaac     1320

cgctccgccc ctaacgatgt tccgtgtttg ttaccccagg aatatgtgac tcatttcgtt     1380

tccgaacagg cacccaccat gggggacgct gccctgctac actatgtgga ccccgacacc     1440

aatagaaacc tcggcgagtt caaactctac cccgggggat acctgacctg tgttccaaat     1500

ggagtgggag caggcccaca acagctgccc ctgaatgggg tcttcctgtt cgtttcttgg     1560

gtgtcacgct tttaccagct gaagcccgtt ggcacagctt ctacggcacg cggcaggcta     1620

ggggtccgcc gaatctga                                                   1638


<210>  58
<211>  1629
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon optimized S(GI.1)+P(GI.3) 
       fusion VP1

<400>  58
atgatgatgg ctagtaaaga tgcgacctcc tctgtggatg gtgcgtcagg ggcaggacaa       60

ctcgtacccg aggtaaacgc cagcgaccca cttgccatgg accccgttgc cggaagttcc      120

acagcagtgg ccacagccgg tcaagtgaat ccaattgatc cgtggattat caacaatttc      180

gtccaggcac cccagggcga gttcacaatt tcaccaaaca atacaccggg cgatgtgcta      240

ttcgatcttt ccttgggtcc tcaccttaac ccttttctac tccatctctc acagatgtac      300

aatggttggg taggaaacat gagagtccgg atcatgctgg ctggcaatgc ctttaccgct      360

ggcaagatca tcgtcagttg tattcctccc ggatttggat ctcataatct gaccattgct      420

caagcgactc tctttcccca tgtcatcgcc gacgttagga ccctggaccc catcgaggtg      480

cccctggagg acgtccggaa tgttttgttc cacaacaacg acagaaacca gcagacgatg      540

agacttgtct gtatgctcta taccccactg cggactggag gcgggactgg agactccttc      600

gttgtggcag gaagagtgat gacatgcccc tcccccgact tcaactttct ttttctggtc      660

ccaccaaccg ttgagcagaa aacaaagcca ttcagcgtgc caaacctgcc ccttaacgtg      720

ctgtcgaatt cccgagtgcc ttcccttatt aagtccatga tggtatctca ggatcacggt      780

caaatggtgc agtttcagaa cggccgagtg acgttagacg ggcagctgca gggcacaacc      840

ccaaccagtg ccagtcagct gtgtaagatc agaggcaccg tctaccacgc aactggcgga      900

caggggctga atcttactga gatcgatggt accccctacc atgcattcga gtcacctgca      960

cctattggat ttcccgatct tggggagtgt gattggcata tcaatgcttc acctgccaac     1020

gctttcacag acgggtctat tattcatcgc attgacgtag cacaggatag cacatttgcc     1080

ccgcacctgg gtaccatcca ctatacgaac gcagattaca acgcaaacgt gggtcttatc     1140

tgtagcctag agtggctatc tccgccaagc ggtggggccc ctaaagttaa cccatgggct     1200

attcctcggt acgggtctac gctgactgag gccgctcagc tggcaccccc catatatcca     1260

ccaggattcg gggaagccat tgttttcttt atgtccgatt ttccgatagc caacggttca     1320

gatggcctta gtgtcccttg cacgattcca caggaatttg tgacacactt cgtaaacgag     1380

caggctccta ctcggggcga ggctgccttg ttgcattacg tagaccccga tacccataga     1440

aacctgggcg aattcaaact ctaccctgaa ggtttcatga cctgcgtacc taactcctcc     1500

ggcagtggcc ctcaaacctt gccgatcaac ggcgtgttca cgtttatcag ctgggtttca     1560

cggttttacc aactcaagcc cgtcggaaca actgggccag ttcggaggct cgggatcaga     1620

cggagctag                                                             1629


<210>  59
<211>  1635
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon optimized S(GI.1)+P(GII.4) 
       fusion VP1

<400>  59
atgatgatgg ctagtaaaga tgcgacctcc tctgtggatg gtgcgtcagg ggcaggacaa       60

ctcgtacccg aggtaaacgc cagcgaccca cttgccatgg accccgttgc cggaagttcc      120

acagcagtgg ccacagccgg tcaagtgaat ccaattgatc cgtggattat caacaatttc      180

gtccaggcac cccagggcga gttcacaatt tcaccaaaca atacaccggg cgatgtgcta      240

ttcgatcttt ccttgggtcc tcaccttaac ccttttctac tccatctctc acagatgtac      300

aatggttggg taggaaacat gagagtccgg atcatgctgg ctggcaatgc ctttaccgct      360

ggcaagatca tcgtcagttg tattcctccc ggatttggat ctcataatct gaccattgct      420

caagcgactc tctttcccca tgtcatcgcc gacgttagga ccctggaccc catcgaggtg      480

cccctggagg acgtccggaa tgttttgttc cacaacaacg acagaaacca gcagacgatg      540

agacttgtct gtatgctcta taccccactg cggactggag gcgggactgg agactccttc      600

gttgtggcag gaagagtgat gacatgcccc tcccccgact tcaactttct ttttctggtc      660

ccaccaaccg ttgagagccg aaccaagccc tttagtgtcc ccgtactcac agtcgaggag      720

atgacaaata gccgctttcc aatccccctt gagaaactgt tcacaggacc ttcctcggca      780

ttcgtggttc agccacagaa cggacgctgc acaactgacg gcgtgctgct cggaaccacc      840

cagcttagcc ctgttaatat ctgtacgttt agaggcgacg taactcacat aactggctca      900

cggaactata ccatgaatct ggcatcacag aattggaatg actacgaccc aaccgaagag      960

attcccgcac ctcttggaac ccccgacttt gtgggaaaaa tacagggcgt cctgacacaa     1020

accaccagaa ccgatggctc cacacgggga cacaaggcaa ccgtctacac tggctctgcc     1080

gattttgccc cgaaactggg tagagtgcag tttgagaccg acactgaccg ggactttgaa     1140

gccaatcaga atactaagtt cacacctgta ggagtgattc aggacggggg caccactcac     1200

cggaacgagc cgcaacaatg ggtcctgccc tcttatagcg ggaggaatac tcataatgtg     1260

catttggctc ctgcagtggc tcccacgttt cccggggaac aactgctctt ttttcgttca     1320

accatgcctg gatgctccgg atatcccaat atggatctcg attgcctgct cccacaggaa     1380

tgggtgcagt atttttatca agaggccgca ccagcccaat ccgacgtcgc acttctgcgg     1440

ttcgtgaatc cagacacagg ccgcgtgttg tttgagtgca aattgcacaa atcaggatac     1500

gttacagtgg ctcatactgg acagcatgac ctggtgatcc cacccaacgg atattttagg     1560

ttcgactcct gggtgaatca gttttataca ttagccccca tggggaatgg gactggcaga     1620

cgcagggctg tctga                                                      1635


<210>  60
<211>  1644
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP1 
       GII.6_Ohio_2012_M9T020

<400>  60
atgaagatgg caagcaacga cgcagctccc tccaatgatg gtgccgccaa cctggtcccc       60

gaagctaata atgaggtgat ggcgttagag ccggtggttg gcgcatctat tgcagcgcct      120

gtggtcggac agcagaacat cattgatccc tggattcgcg agaacttcgt acaagctcca      180

cagggggagt tcacagtctc cccccggaac tccccgggcg agatgctgct caatctggaa      240

ctcggccctg aactaaaccc ttatctgtca cacctttcac ggatgtacaa tggctacgca      300

ggaggaatgc aagttcaggt ggtcctggcc ggcaatgctt tcaccgcggg caaaatcatc      360

tttgcggccg ttcctccaca cttccctgtc gaaaatatca acgccgccca gattactatg      420

tgcccccacg tgattgtgga tgtgcgacag ttagagccag ttctgctgcc cctgcccgac      480

atcagaaacc ggttcttcca ttacaatcaa gagaatactt cacggatgag acttgttgcg      540

atgctgtaca cccctcttcg tgcaaattcc ggcgaagacg tgttcactgt gtcttgtcga      600

gtacttaccc gacccgcccc cgatttcgaa ttcaccttcc tggttccccc tactgtggag      660

agcaagacaa aacccttcag cctcccaatc ttaacactcg gggagctgtc taattcacgc      720

ttccccgcac ctattgatat gctgtatact gaccccaacg aggggatagt ggtgcagccc      780

caaaatggac ggtgtactct cgacggcacg ctccagggca caacccaact ggtgccaacc      840

cagatttgtg cattcagggg cactttgatt gggcagacat cgagatctcc agattctact      900

gattccgcgc caaggaggag ggaccaccca ctccacgttc agttaaaaaa cctggacgga      960

acccagtacg accctacaga cgaggtcccc gctgtcctcg gagccatcga ctttaaagga     1020

actgtatttg gagtggcatc ccaaagggat gtctcggggc agcaggtggg agctacgaga     1080

gcacatgaag tccacattaa caccacagac ccaagatata ccccaaaact agggtcaatt     1140

ttaatgtatt cggaatcaga cgattttgtt acaggtcagc ccgtgcggtt taccccgatc     1200

ggaatggggg acaacgattg gcaccagtgg gaattgcccg attaccctgg acacctcacc     1260

ttgaatatga atctggcccc agccgtcgcg cccgccttcc ccggtgagcg gatcctcttt     1320

tttagaagca tagtgccctc cgcaggtggg tatggatcag ggcagattga ttgcctgatc     1380

ccccaagaat gggtacagca tttctaccag gaagcagccc ctagccagtc cgcagtagca     1440

ctgatcagat atgttaatcc tgatacggga aggaacatct tcgaagcaaa actgcaccgt     1500

gagggcttca ttaccgtcgc caacagtggt aataacccta ttgtggtgcc tcctaatgga     1560

tacttcaggt ttgaggcatg ggtgaatcag ttttatactc tgactcccat ggggacaggc     1620

caggggcgac gccgggatca gtga                                            1644


<210>  61
<211>  1629
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP1 
       GII.13_VA173_2010_H9AWU4

<400>  61
atgaaaatgg cttctaatga tgccgcgccc agcaatgatg gtgccgccag ccttgtgccc       60

gaagcaatta acgagacaat gcccttggag ccagtcgccg gggcttctat tgcggcccca      120

gttgctggac agacgaatat catcgatcct tggatacgga ctaattttgt tcaagctcct      180

aacggagagt tcactgtctc cccccgtaat agtcctggcg agatcctgtt gaacctcgag      240

ttggggccag atctcaatcc ttacctggct catctgtcga gaatgtacaa cgggtacgcg      300

gggggggttg aggtgcaggt cttactggca ggtaacgcat tcacagcagg caagattctg      360

tttgcggcca tccctcctaa ttttccagtg gatatgatat ctccagcaca gattacaatg      420

ctgccccatt tgatagtgga tgtgcggaca cttgaaccta tcatgatccc tttgcccgat      480

gtccgaaatg tgttttatca tttcaacaac cagccgcagc caagaatgcg tctcgtcgcg      540

atgctgtaca ccccgttgcg gtccaacggc tctggcgatg atgttttcac agtgtcgtgt      600

cgagtgttaa cccgccctac cccagatttt gagtttatat atctagttcc cccttctgtg      660

gaaagcaaga ctaaaccctt tactcttccc attctgacta tatccgagct taccaactcc      720

cggttcccca tctcaatcga gcaactgtac actgcaccca acgagaacaa cgtagtccag      780

tgccagaacg ggagatgtac cctggacggg gagctccaag ggaccacgca actgttaagt      840

tcagccgttt gcagttacag aggcaggact gtggcgaact ctggtgataa ctgggatcaa      900

aatgtgttgc agctgactta cccatccggc gcaagctacg atccaacaga tgaggtgcca      960

gcgccccttg gcacacagga tttctcagga attctatacg gggtgcttac tcaggataat     1020

gtgcgagaaa atactggcga ggccaagaat gctaaaggag tgtatataag cacgacaagc     1080

ggtaagttta cccccaaaat tggcagtatt gggctccaca gcattactga ggacgtccgc     1140

ccaaaccagc agtctcgttt cactcccgtg ggggtggcac agaacgagaa cacacctttc     1200

cagcagtggg tcttgcccca ttatgcaggt gctttggcgc tcaatacaaa tctggcaccc     1260

gccgtagcgc cgacatttcc tggggagcaa ttgctgttct ttagaagccg cgtcccgtgt     1320

gttcagggct tgcagggcca ggacgcgttc attgattgcc tcttgcccca ggaatgggtc     1380

aaccactttt atcaggaggc agcgccctct caagcagatg tggccctgat aagatatgtg     1440

aatcccgaca caggacggac tttgtttgag gcaaaactcc accggtcagg attcattact     1500

gtgagtcaca caggagccta tccccttgtg gttccaccta atggccactt caggttcgac     1560

tcttgggtca atcagtttta ttcgctggca ccaatgggta ccgggaatgg tcgccgtcgg     1620

gtgcaatga                                                             1629


<210>  62
<211>  1617
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP1 
       GII.17_Kawa_2014_A0A077KVU6

<400>  62
atgaaaatgg catctaacga cgcagccccc tcaaacgatg gcgctgctgg actcgtgccg       60

gaggggaata atgagacact tccactagag ccggttgcag gcgccgctat agctgcccca      120

gtgacagggc agaataatat tatagaccct tggattcgga caaacttcgt gcaggcaccc      180

aacggcgagt ttacagtatc cccccggaac tccccaggtg agatactcct gaatcttgag      240

ctcggccctg acctcaatcc atatctggct catctgagcc gcatgtacaa tggttacgct      300

gggggggtcg aagtgcaggt cctcctggcc ggaaacgcct ttaccgctgg caaaattctg      360

tttgccgccg ttccaccaaa ctttccagtc gaattcctct ctcccgcgca aataaccatg      420

ctgccacatt tgatcgttga cgtgcggacc ctggagccaa taatgattcc cctgccggat      480

gtgcgtaaca cctttttcca ttataacaat cagccaaact ctcggatgag acttgttgct      540

atgctgtaca cccccctgcg gagcaacggc agtggcgatg atgtgtttac cgtgagttgc      600

agagtcctga cgcgcccaac cccggacttc gagttcacct acctggtgcc cccttctgtg      660

gaatctaaga ccaaaccgtt ttcactgcca atcttaactc tctccgaact gactaacagc      720

cggtttccag tacccataga ttctcttttt accgctcaaa acaacgtact ccaagtccag      780

tgccagaacg gccgctgtac gcttgatggt gagttgcagg ggacaacaca gctactcccc      840

agtggcatct gtgcattccg gggccgcgtg accgctgaga cagaccatcg tgacaaatgg      900

cacatgcaac tccaaaactt aaacgggacc acctacgacc caaccgacga cgtccctgct      960

ccgctaggga ctcctgactt taagggggtg gtgttcggag tggcctctca gcggaatgtt     1020

gggaatgacg cccccggctc tacccgagct cacgaggccg ttatctcaac atatagcccc     1080

caatttgtgc ccaagctcgg atccgttaat tttcgtagta acgacaacga cttccaactg     1140

caaccaacga agtttacgcc agtggggatt aatgatgatg gagaccatcc tttccgccaa     1200

tgggaactac cagattattc tgggctgctc accctcaata tgaacctcgc cccacccgtg     1260

gcccctaatt tccccggtga gcagctgctg ttttttcgga gctttgtgcc atgcagtggc     1320

ggatataatc aaggcatcgt agactgcttg attccccaag agtggataca acatttttac     1380

caggaaagtg cgccctccca gtccgatgtg gccctgatac ggtacgttaa ccccgatacc     1440

ggaagaacat tattcgaagc gaaattgcac agatcagggt acattaccgt tgcacattcc     1500

ggcgattatc ccctggtggt tcccgccaac ggttacttta ggttcgatag ttgggtcaac     1560

cagttctatt cactagcccc aatgggcacc ggtaacggca gacgccgggc tcagtag        1617


<210>  63
<211>  1659
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon optimized S(GI.1)+P(GII.6) 
       fusion VP1

<400>  63
atgatgatgg ctagtaaaga tgcgacctcc tctgtggatg gtgcgtcagg ggcaggacaa       60

ctcgtacccg aggtaaacgc cagcgaccca cttgccatgg accccgttgc cggaagttcc      120

acagcagtgg ccacagccgg tcaagtgaat ccaattgatc cgtggattat caacaatttc      180

gtccaggcac cccagggcga gttcacaatt tcaccaaaca atacaccggg cgatgtgcta      240

ttcgatcttt ccttgggtcc tcaccttaac ccttttctac tccatctctc acagatgtac      300

aatggttggg taggaaacat gagagtccgg atcatgctgg ctggcaatgc ctttaccgct      360

ggcaagatca tcgtcagttg tattcctccc ggatttggat ctcataatct gaccattgct      420

caagcgactc tctttcccca tgtcatcgcc gacgttagga ccctggaccc catcgaggtg      480

cccctggagg acgtccggaa tgttttgttc cacaacaacg acagaaacca gcagacgatg      540

agacttgtct gtatgctcta taccccactg cggactggag gcgggactgg agactccttc      600

gttgtggcag gaagagtgat gacatgcccc tcccccgact tcaactttct ttttctggtc      660

ccaccaaccg ttgagagcaa gacaaaaccc ttcagcctcc caatcttaac actcggggag      720

ctgtctaatt cacgcttccc cgcacctatt gatatgctgt atactgaccc caacgagggg      780

atagtggtgc agccccaaaa tggacggtgt actctcgacg gcacgctcca gggcacaacc      840

caactggtgc caacccagat ttgtgcattc aggggcactt tgattgggca gacatcgaga      900

tctccagatt ctactgattc cgcgccaagg aggagggacc acccactcca cgttcagtta      960

aaaaacctgg acggaaccca gtacgaccct acagacgagg tccccgctgt cctcggagcc     1020

atcgacttta aaggaactgt atttggagtg gcatcccaaa gggatgtctc ggggcagcag     1080

gtgggagcta cgagagcaca tgaagtccac attaacacca cagacccaag atatacccca     1140

aaactagggt caattttaat gtattcggaa tcagacgatt ttgttacagg tcagcccgtg     1200

cggtttaccc cgatcggaat gggggacaac gattggcacc agtgggaatt gcccgattac     1260

cctggacacc tcaccttgaa tatgaatctg gccccagccg tcgcgcccgc cttccccggt     1320

gagcggatcc tcttttttag aagcatagtg ccctccgcag gtgggtatgg atcagggcag     1380

attgattgcc tgatccccca agaatgggta cagcatttct accaggaagc agcccctagc     1440

cagtccgcag tagcactgat cagatatgtt aatcctgata cgggaaggaa catcttcgaa     1500

gcaaaactgc accgtgaggg cttcattacc gtcgccaaca gtggtaataa ccctattgtg     1560

gtgcctccta atggatactt caggtttgag gcatgggtga atcagtttta tactctgact     1620

cccatgggga caggccaggg gcgacgccgg gatcagtga                            1659


<210>  64
<211>  1641
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon optimized S(GI.1)+P(GII.13) 
       fusion VP1

<400>  64
atgatgatgg ctagtaaaga tgcgacctcc tctgtggatg gtgcgtcagg ggcaggacaa       60

ctcgtacccg aggtaaacgc cagcgaccca cttgccatgg accccgttgc cggaagttcc      120

acagcagtgg ccacagccgg tcaagtgaat ccaattgatc cgtggattat caacaatttc      180

gtccaggcac cccagggcga gttcacaatt tcaccaaaca atacaccggg cgatgtgcta      240

ttcgatcttt ccttgggtcc tcaccttaac ccttttctac tccatctctc acagatgtac      300

aatggttggg taggaaacat gagagtccgg atcatgctgg ctggcaatgc ctttaccgct      360

ggcaagatca tcgtcagttg tattcctccc ggatttggat ctcataatct gaccattgct      420

caagcgactc tctttcccca tgtcatcgcc gacgttagga ccctggaccc catcgaggtg      480

cccctggagg acgtccggaa tgttttgttc cacaacaacg acagaaacca gcagacgatg      540

agacttgtct gtatgctcta taccccactg cggactggag gcgggactgg agactccttc      600

gttgtggcag gaagagtgat gacatgcccc tcccccgact tcaactttct ttttctggtc      660

ccaccaaccg ttgagagcaa gactaaaccc tttactcttc ccattctgac tatatccgag      720

cttaccaact cccggttccc catctcaatc gagcaactgt acactgcacc caacgagaac      780

aacgtagtcc agtgccagaa cgggagatgt accctggacg gggagctcca agggaccacg      840

caactgttaa gttcagccgt ttgcagttac agaggcagga ctgtggcgaa ctctggtgat      900

aactgggatc aaaatgtgtt gcagctgact tacccatccg gcgcaagcta cgatccaaca      960

gatgaggtgc cagcgcccct tggcacacag gatttctcag gaattctata cggggtgctt     1020

actcaggata atgtgcgaga aaatactggc gaggccaaga atgctaaagg agtgtatata     1080

agcacgacaa gcggtaagtt tacccccaaa attggcagta ttgggctcca cagcattact     1140

gaggacgtcc gcccaaacca gcagtctcgt ttcactcccg tgggggtggc acagaacgag     1200

aacacacctt tccagcagtg ggtcttgccc cattatgcag gtgctttggc gctcaataca     1260

aatctggcac ccgccgtagc gccgacattt cctggggagc aattgctgtt ctttagaagc     1320

cgcgtcccgt gtgttcaggg cttgcagggc caggacgcgt tcattgattg cctcttgccc     1380

caggaatggg tcaaccactt ttatcaggag gcagcgccct ctcaagcaga tgtggccctg     1440

ataagatatg tgaatcccga cacaggacgg actttgtttg aggcaaaact ccaccggtca     1500

ggattcatta ctgtgagtca cacaggagcc tatccccttg tggttccacc taatggccac     1560

ttcaggttcg actcttgggt caatcagttt tattcgctgg caccaatggg taccgggaat     1620

ggtcgccgtc gggtgcaatg a                                               1641


<210>  65
<211>  1629
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon optimized S(GI.1)+P(GII.17) 
       fusion VP1

<400>  65
atgatgatgg ctagtaaaga tgcgacctcc tctgtggatg gtgcgtcagg ggcaggacaa       60

ctcgtacccg aggtaaacgc cagcgaccca cttgccatgg accccgttgc cggaagttcc      120

acagcagtgg ccacagccgg tcaagtgaat ccaattgatc cgtggattat caacaatttc      180

gtccaggcac cccagggcga gttcacaatt tcaccaaaca atacaccggg cgatgtgcta      240

ttcgatcttt ccttgggtcc tcaccttaac ccttttctac tccatctctc acagatgtac      300

aatggttggg taggaaacat gagagtccgg atcatgctgg ctggcaatgc ctttaccgct      360

ggcaagatca tcgtcagttg tattcctccc ggatttggat ctcataatct gaccattgct      420

caagcgactc tctttcccca tgtcatcgcc gacgttagga ccctggaccc catcgaggtg      480

cccctggagg acgtccggaa tgttttgttc cacaacaacg acagaaacca gcagacgatg      540

agacttgtct gtatgctcta taccccactg cggactggag gcgggactgg agactccttc      600

gttgtggcag gaagagtgat gacatgcccc tcccccgact tcaactttct ttttctggtc      660

ccaccaaccg ttgagtctaa gaccaaaccg ttttcactgc caatcttaac tctctccgaa      720

ctgactaaca gccggtttcc agtacccata gattctcttt ttaccgctca aaacaacgta      780

ctccaagtcc agtgccagaa cggccgctgt acgcttgatg gtgagttgca ggggacaaca      840

cagctactcc ccagtggcat ctgtgcattc cggggccgcg tgaccgctga gacagaccat      900

cgtgacaaat ggcacatgca actccaaaac ttaaacggga ccacctacga cccaaccgac      960

gacgtccctg ctccgctagg gactcctgac tttaaggggg tggtgttcgg agtggcctct     1020

cagcggaatg ttgggaatga cgcccccggc tctacccgag ctcacgaggc cgttatctca     1080

acatatagcc cccaatttgt gcccaagctc ggatccgtta attttcgtag taacgacaac     1140

gacttccaac tgcaaccaac gaagtttacg ccagtgggga ttaatgatga tggagaccat     1200

cctttccgcc aatgggaact accagattat tctgggctgc tcaccctcaa tatgaacctc     1260

gccccacccg tggcccctaa tttccccggt gagcagctgc tgttttttcg gagctttgtg     1320

ccatgcagtg gcggatataa tcaaggcatc gtagactgct tgattcccca agagtggata     1380

caacattttt accaggaaag tgcgccctcc cagtccgatg tggccctgat acggtacgtt     1440

aaccccgata ccggaagaac attattcgaa gcgaaattgc acagatcagg gtacattacc     1500

gttgcacatt ccggcgatta tcccctggtg gttcccgcca acggttactt taggttcgat     1560

agttgggtca accagttcta ttcactagcc ccaatgggca ccggtaacgg cagacgccgg     1620

gctcagtag                                                             1629


<210>  66
<211>  542
<212>  PRT
<213>  Norovirus GII.2/CGMH47/2011/TW

<400>  66

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Thr Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ser Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Leu Ala Ala Pro Val Thr Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Ala Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Met Glu Val Gln Val Met Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Val Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Val Glu Asn Leu Ser Pro Gln Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Leu Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Lys Asp Asp Pro Lys Met 
                165                 170                 175     


Arg Ile Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Asp Phe Thr Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Leu Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Ser Ile Asp Gln Met Tyr Thr Ser Pro Asn Glu Val 
                245                 250                 255     


Ile Ser Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Gln Val Ser Gly Ile Cys Ala Phe Lys Gly 
        275                 280                 285             


Glu Val Thr Ala His Leu His Asp Asn Asp His Leu Tyr Asn Val Thr 
    290                 295                 300                 


Ile Thr Asn Leu Asn Gly Ser Pro Phe Asp Pro Ser Glu Asp Ile Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Val Pro Asp Phe Gln Gly Arg Val Phe Gly Val Ile 
                325                 330                 335     


Ser Gln Arg Asp Lys His Asn Thr Pro Gly His Asn Glu Pro Ala Asn 
            340                 345                 350         


Arg Ala His Asp Ala Val Val Pro Thr Tyr Thr Ala Gln Tyr Thr Pro 
        355                 360                 365             


Lys Leu Gly Gln Ile Gln Ile Gly Thr Trp Gln Thr Asp Asp Leu Thr 
    370                 375                 380                 


Val Asn Gln Pro Val Lys Phe Thr Pro Val Gly Leu Asn Asp Thr Asp 
385                 390                 395                 400 


His Phe Asn Gln Trp Val Val Pro Arg Tyr Ala Gly Ala Leu Asn Leu 
                405                 410                 415     


Asn Thr Asn Leu Ala Pro Ser Val Ala Pro Val Phe Pro Gly Glu Arg 
            420                 425                 430         


Leu Leu Phe Phe Arg Ser Tyr Ile Pro Leu Lys Gly Gly Tyr Gly Thr 
        435                 440                 445             


Pro Ala Ile Asp Cys Leu Leu Pro Gln Glu Trp Val Gln His Phe Tyr 
    450                 455                 460                 


Gln Glu Ala Ala Pro Ser Met Ser Glu Val Ala Leu Val Arg Tyr Ile 
465                 470                 475                 480 


Asn Pro Asp Thr Gly Arg Ala Leu Phe Glu Ala Lys Leu His Arg Ala 
                485                 490                 495     


Gly Phe Met Thr Val Ser Ser Asn Thr Ser Ala Pro Val Val Val Pro 
            500                 505                 510         


Ala Asn Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser 
        515                 520                 525             


Leu Ala Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Ile Gln 
    530                 535                 540         


<210>  67
<211>  548
<212>  PRT
<213>  Norovirus GII.3/Jingzhou/2013402/CHN

<400>  67

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Ser Ser Glu Ala Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ala Ile Ala Ala Pro Leu Thr Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Met Asn Asn Phe Val Gln Ala Pro Gly Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Ile Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Phe Glu Val Gln Val Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Ile Pro Pro Asn Phe 
        115                 120                 125             


Pro Ile Asp Asn Leu Ser Ala Ala Gln Ile Thr Met Cys Pro His Val 
    130                 135                 140                 


Ile Val Asp Val Arg Gln Leu Glu Pro Val Asn Leu Pro Met Pro Asp 
145                 150                 155                 160 


Val Arg Asn Asn Phe Phe His Tyr Asn Gln Gly Ser Asp Ser Arg Leu 
                165                 170                 175     


Arg Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Asp Phe Ser Phe Asn Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Ser Leu Pro Ile Leu Thr Ile Ser Glu Met Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Ile Asp Ser Leu His Thr Ser Pro Thr Glu Asn 
                245                 250                 255     


Ile Val Val Gln Cys Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Met Gly Thr Thr Gln Leu Leu Pro Ser Gln Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Thr Leu Thr Arg Ser Thr Ser Arg Ala Ser Asp Gln Ala Asp Thr Ala 
    290                 295                 300                 


Thr Pro Arg Leu Phe Asn Tyr Tyr Trp His Ile Gln Leu Asp Asn Leu 
305                 310                 315                 320 


Asn Gly Thr Pro Tyr Asp Pro Ala Glu Asp Ile Pro Ala Pro Leu Gly 
                325                 330                 335     


Thr Pro Asp Phe Arg Gly Lys Val Phe Gly Val Ala Ser Gln Arg Asn 
            340                 345                 350         


Pro Asp Ala Thr Thr Arg Ala His Glu Ala Lys Ile Asp Thr Thr Ser 
        355                 360                 365             


Gly Arg Phe Thr Pro Lys Leu Gly Ser Leu Glu Ile Ser Thr Glu Ser 
    370                 375                 380                 


Gly Asp Phe Asp Gln Asn Gln Pro Thr Arg Phe Thr Pro Val Gly Ile 
385                 390                 395                 400 


Gly Val Asp His Glu Pro Asp Phe Gln Gln Trp Ala Leu Pro Asp Tyr 
                405                 410                 415     


Ala Gly Gln Phe Thr His Asn Met Asn Leu Ala Pro Ala Val Ala Pro 
            420                 425                 430         


Asn Phe Pro Gly Glu Gln Leu Leu Phe Phe Arg Ser Gln Leu Pro Ser 
        435                 440                 445             


Ser Gly Gly Arg Ser Asn Gly Ile Leu Asp Cys Leu Val Pro Gln Glu 
    450                 455                 460                 


Trp Val Gln His Phe Tyr Gln Glu Ser Ala Pro Ser Gln Thr Gln Val 
465                 470                 475                 480 


Ala Leu Val Arg Tyr Val Asn Pro Asp Thr Gly Arg Val Leu Phe Glu 
                485                 490                 495     


Ala Lys Leu His Lys Leu Arg Phe Met Thr Ile Ala Lys Ser Gly Asp 
            500                 505                 510         


Ser Pro Ile Thr Val Pro Pro Asn Gly Tyr Phe Arg Phe Glu Ser Trp 
        515                 520                 525             


Val Asn Pro Phe Tyr Thr Leu Ala Pro Met Gly Thr Gly Asn Gly Arg 
    530                 535                 540                 


Arg Arg Ile Gln 
545             


<210>  68
<211>  540
<212>  PRT
<213>  Norovirus GII.5/AlbertaEI390/2013/CA

<400>  68

Met Lys Met Ala Ser Asn Asp Ala Thr Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ser Asn Asn Glu Ala Met Ala Leu Glu Pro Val 
            20                  25                  30          


Val Gly Ala Ser Leu Ala Ala Pro Val Thr Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Thr Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Val Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Met Glu Val Gln Val Leu Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Val Pro Pro Tyr Phe 
        115                 120                 125             


Pro Val Glu Asn Leu Ser Pro Ser Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 


Val Arg Ser Thr Leu Phe His Phe Asn Gln Lys Asp Glu Pro Lys Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Ile Leu Thr Arg Pro Ser Pro 
        195                 200                 205             


Glu Phe Asp Phe Thr Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Val Leu Thr Leu Gly Glu Leu Ser Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Leu Ser Ile Asp Glu Met Val Thr Ser Pro Asn Glu Ser 
                245                 250                 255     


Ile Val Val Gln Pro Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Gln Leu Gln Ala Cys Asn Ile Cys Ser Ile Arg Gly 
        275                 280                 285             


Lys Val Thr Gly Gln Val Pro Asn Glu Gln His Met Trp Asn Leu Glu 
    290                 295                 300                 


Ile Thr Asn Leu Asn Gly Thr Gln Phe Asp Pro Thr Asp Asp Val Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Val Pro Asp Phe Ala Gly Glu Val Phe Gly Val Leu 
                325                 330                 335     


Ser Gln Arg Asn Arg Gly Glu Ser Asn Pro Ala Asn Arg Ala His Asp 
            340                 345                 350         


Ala Val Val Ala Thr Tyr Ser Asp Lys Tyr Thr Pro Lys Leu Gly Leu 
        355                 360                 365             


Val Gln Ile Gly Thr Trp Asn Thr Asn Asp Val Glu Asn Gln Pro Thr 
    370                 375                 380                 


Lys Phe Thr Pro Ile Gly Leu Asn Glu Val Ala Asn Gly His Arg Phe 
385                 390                 395                 400 


Glu Gln Trp Thr Leu Pro Arg Tyr Ser Gly Ala Leu Thr Leu Asn Met 
                405                 410                 415     


Asn Leu Ala Pro Ala Val Ala Pro Leu Phe Pro Gly Glu Arg Leu Leu 
            420                 425                 430         


Phe Phe Arg Ser Tyr Val Pro Leu Lys Gly Gly Phe Gly Asn Pro Ala 
        435                 440                 445             


Ile Asp Cys Leu Val Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ser Ala Pro Ser Leu Gly Asp Val Ala Leu Val Arg Tyr Val Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Lys Gly Gly Phe 
                485                 490                 495     


Leu Thr Val Ser Ser Thr Ser Thr Gly Pro Val Val Val Pro Ala Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala 
        515                 520                 525             


Pro Met Gly Thr Gly Asn Gly Arg Arg Arg Phe Gln 
    530                 535                 540 


<210>  69
<211>  540
<212>  PRT
<213>  Norovirus GII.7/Musahimurayama/2010/JP

<400>  69

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ile Asn Asn Glu Val Met Pro Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Leu Ala Thr Pro Val Val Gly Gln Gln Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Asn Asn Phe Val Gln Ala Pro Ala Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Ile Leu Leu Asp Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ala Arg Met Tyr 
                85                  90                  95      


Asn Gly His Ala Gly Gly Met Glu Val Gln Ile Val Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Ile Ile Phe Ala Ala Ile Pro Pro Gly Phe 
        115                 120                 125             


Pro Tyr Glu Asn Leu Ser Pro Ser Gln Ile Thr Met Cys Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Gln Leu Glu Pro Val Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 


Ile Arg Asn Asn Phe Phe His Tyr Asn Gln Gly Asn Asp Pro Lys Leu 
                165                 170                 175     


Arg Leu Ile Ala Met Leu Tyr Thr Pro Leu Arg Ala Asn Asn Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Lys Pro Ser Pro 
        195                 200                 205             


Asp Phe Glu Phe Thr Phe Leu Val Pro Pro Thr Val Glu Ser Lys Thr 
    210                 215                 220                 


Lys Gln Phe Thr Leu Pro Ile Leu Lys Ile Ser Glu Met Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Val Pro Val Glu Met Met Tyr Thr Ala Arg Asn Glu Asn 
                245                 250                 255     


Gln Val Val Gln Pro Gln Asn Gly Arg Val Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Leu Gly Thr Thr Pro Leu Leu Ala Val Asn Ile Cys Lys Phe Lys Gly 
        275                 280                 285             


Glu Val Ile Ala Lys Asn Gly Asp Val Arg Ser Tyr Arg Met Asp Met 
    290                 295                 300                 


Glu Ile Thr Asn Thr Asp Gly Thr Pro Ile Asp Pro Thr Glu Asp Thr 
305                 310                 315                 320 


Pro Gly Pro Ile Gly Ser Pro Asp Phe Gln Gly Ile Leu Phe Gly Val 
                325                 330                 335     


Ala Ser Gln Arg Asn Lys Asn Glu Gln Asn Pro Ala Thr Arg Ala His 
            340                 345                 350         


Glu Ala Asn Ile Asn Thr Gly Gly Asp Gln Tyr Ala Pro Lys Leu Ala 
        355                 360                 365             


Gln Val Lys Phe Phe Ser Glu Ser Gln Asp Phe Glu Val His Gln Pro 
    370                 375                 380                 


Thr Val Phe Thr Pro Val Gly Val Ala Gly Asp Thr Ser His Pro Phe 
385                 390                 395                 400 


Arg Gln Trp Val Leu Pro Arg Tyr Gly Gly His Leu Thr Asn Asn Thr 
                405                 410                 415     


His Leu Ala Pro Ala Val Ala Pro Leu Phe Pro Gly Glu Gln Ile Leu 
            420                 425                 430         


Phe Phe Arg Ser Gln Ile Pro Ser Ser Gly Gly His Glu Leu Gly Tyr 
        435                 440                 445             


Met Asp Cys Leu Val Pro Gln Glu Trp Val Gln His Phe Tyr Gln Glu 
    450                 455                 460                 


Ala Ala Thr Ala Gln Ser Glu Val Ala Leu Ile Arg Phe Ile Asn Pro 
465                 470                 475                 480 


Asp Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Lys Gln Gly Phe 
                485                 490                 495     


Ile Thr Val Ala His Thr Gly Asp Asn Pro Ile Val Met Pro Pro Asn 
            500                 505                 510         


Gly Tyr Phe Arg Phe Glu Ala Trp Val Asn Gln Phe Tyr Ser Leu Ala 
        515                 520                 525             


Pro Val Gly Thr Gly Asn Gly Arg Arg Arg Ile Gln 
    530                 535                 540 


<210>  70
<211>  571
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of VP1 consensus sequence from genotypes 
       GI.1, GI.2, GI.3, GII.4, GII.6, GII.13 and GII.17


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be Lys or Met

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa can be Asn, Ser or Lys

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa can be Ala, Asn, Pro or Thr

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa can be Pro, Thr, Gln or Ser

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa can be Ser or Asn

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa can be Asn, Asp, Met, Ala or Val

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa can be Asp or Gly

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa can be Ala, Thr or absent

<220>
<221>  VARIANT
<222>  (15)..(315)
<223>  Xaa can be Arg, Try, Asp or absent

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa can be Gly or absent

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Xaa can be Ala or Gly

<220>
<221>  VARIANT
<222>  (20)..(20)
<223>  Xaa can be Gly, Ser, Asn or Gln

<220>
<221>  VARIANT
<222>  (25)..(25)
<223>  Xaa can be Gly, Ala or Val

<220>
<221>  VARIANT
<222>  (26)..(26)
<223>  Xaa can be Asn, Ile or Ser

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  Xaa can be Asn, Thr or Ala

<220>
<221>  VARIANT
<222>  (28)..(28)
<223>  Xaa can be Asn, Ser or absent

<220>
<221>  VARIANT
<222>  (29)..(29)
<223>  Xaa can be Glu or Asp

<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  Xaa can be Thr, Val or Pro

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Xaa can be Leu, Met or Ile

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  Xaa can be Pro, Ala or Ser

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  Xaa can be Leu or Met

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  Xaa can be Glu or Asp

<220>
<221>  VARIANT
<222>  (37)..(37)
<223>  Xaa can be Ala or Val

<220>
<221>  VARIANT
<222>  (39)..(39)
<223>  Xaa can be Ala, Pro or Ser

<220>
<221>  VARIANT
<222>  (40)..(40)
<223>  Xaa can be Ala, Ser or Thr

<220>
<221>  VARIANT
<222>  (41)..(41)
<223>  Xaa can be Ile or Thr

<220>
<221>  VARIANT
<222>  (43)..(43)
<223>  Xaa can be Ala or Val

<220>
<221>  VARIANT
<222>  (44)..(44)
<223>  Xaa can be Pro or Ala

<220>
<221>  VARIANT
<222>  (45)..(45)
<223>  Xaa can be Val or Thr

<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  Xaa can be Thr, Ala or Val

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  Xaa can be Asn, Thr, Gln or Val

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  Xaa can be Ile, Val, Met or Pro

<220>
<221>  VARIANT
<222>  (57)..(57)
<223>  Xaa can be Arg, Met, Val or Ile

<220>
<221>  VARIANT
<222>  (58)..(58)
<223>  Xaa can be Thr, Glu, Asn or Ser

<220>
<221>  VARIANT
<222>  (60)..(60)
<223>  Xaa can be Phe or Tyr

<220>
<221>  VARIANT
<222>  (63)..(63)
<223>  Xaa can be Ala or Ser

<220>
<221>  VARIANT
<222>  (65)..(65)
<223>  Xaa can be Asn, Gln or Gly

<220>
<221>  VARIANT
<222>  (70)..(70)
<223>  Xaa can be Val or Ile

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  Xaa can be Arg or Asn

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  Xaa can be Ser, Ala or Thr

<220>
<221>  VARIANT
<222>  (78)..(78)
<223>  Xaa can be Glu or Asp

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  Xaa can be Ile, Met or Val

<220>
<221>  VARIANT
<222>  (81)..(81)
<223>  Xaa can be Leu, Trp or Phe

<220>
<221>  VARIANT
<222>  (82)..(82)
<223>  Xaa can be Asn, Ser or Asp

<220>
<221>  VARIANT
<222>  (83)..(83)
<223>  Xaa can be Leu or Ala

<220>
<221>  VARIANT
<222>  (84)..(84)
<223>  Xaa can be Glu, Pro, Gln or Ser

<220>
<221>  VARIANT
<222>  (88)..(88)
<223>  Xaa can be Asp, Glu or His

<220>
<221>  VARIANT
<222>  (92)..(92)
<223>  Xaa can be Tyr or Phe

<220>
<221>  VARIANT
<222>  (94)..(94)
<223>  Xaa can be Ala, Ser or Leu

<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  Xaa can be Ser or Ala

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  Xaa can be Arg or Gln

<220>
<221>  VARIANT
<222>  (103)..(103)
<223>  Xaa can be Tyr or Trp

<220>
<221>  VARIANT
<222>  (104)..(104)
<223>  Xaa can be Ala or Val

<220>
<221>  VARIANT
<222>  (106)..(106)
<223>  Xaa can be Gly or Asn

<220>
<221>  VARIANT
<222>  (107)..(107)
<223>  Xaa can be Val, Met or Phe

<220>
<221>  VARIANT
<222>  (108)..(108)
<223>  Xaa can be Glu, Gln, Lys or Arg

<220>
<221>  VARIANT
<222>  (110)..(110)
<223>  Xaa can be Gln or Arg

<220>
<221>  VARIANT
<222>  (111)..(111)
<223>  Xaa can be Val or Ile

<220>
<221>  VARIANT
<222>  (112)..(112)
<223>  Xaa can be Leu, Val, Ile or Met

<220>
<221>  VARIANT
<222>  (119)..(119)
<223>  Xaa can be Thr or Ser

<220>
<221>  VARIANT
<222>  (123)..(123)
<223>  Xaa can be Ile or Val

<220>
<221>  VARIANT
<222>  (124)..(124)
<223>  Xaa can be Leu or Ile

<220>
<221>  VARIANT
<222>  (125)..(125)
<223>  Xaa can be Phe, Ile or Val

<220>
<221>  VARIANT
<222>  (126)..(126)
<223>  Xaa can be Ala, Ser or Cys

<220>
<221>  VARIANT
<222>  (127)..(127)
<223>  Xaa can be Ala or Cys

<220>
<221>  VARIANT
<222>  (128)..(128)
<223>  Xaa can be Val or Ile

<220>
<221>  VARIANT
<222>  (131)..(131)
<223>  Xaa can be Asn, His or Gly

<220>
<221>  VARIANT
<222>  (133)..(133)
<223>  Xaa can be Pro, Ala, Thr or Gly

<220>
<221>  VARIANT
<222>  (134)..(134)
<223>  Xaa can be Val, Thr, Ala or Ser

<220>
<221>  VARIANT
<222>  (135)..(135)
<223>  Xaa can be Glu, Asp, Gln, Ser or His

<220>
<221>  VARIANT
<222>  (136)..(136)
<223>  Xaa can be Phe, Met, Asn, Gly or Ser

<220>
<221>  VARIANT
<222>  (137)..(137)
<223>  Xaa can be Leu, Ile or Val

<220>
<221>  VARIANT
<222>  (138)..(138)
<223>  Xaa can be Ser, Asn or Thr

<220>
<221>  VARIANT
<222>  (139)..(139)
<223>  Xaa can be Pro, Ala or Ile

<220>
<221>  VARIANT
<222>  (140)..(140)
<223>  Xaa can be Ala or Ser

<220>
<221>  VARIANT
<222>  (142)..(142)
<223>  Xaa can be Ile, Val or Ala

<220>
<221>  VARIANT
<222>  (144)..(144)
<223>  Xaa can be Met or Leu

<220>
<221>  VARIANT
<222>  (145)..(145)
<223>  Xaa can be Leu, Cys or Phe

<220>
<221>  VARIANT
<222>  (148)..(148)
<223>  Xaa can be Leu, Val or Ile

<220>
<221>  VARIANT
<222>  (149)..(149)
<223>  Xaa can be Ile or Val

<220>
<221>  VARIANT
<222>  (150)..(150)
<223>  Xaa can be Val or Ala

<220>
<221>  VARIANT
<222>  (154)..(154)
<223>  Xaa can be Thr, Gln or Val

<220>
<221>  VARIANT
<222>  (156)..(156)
<223>  Xaa can be Glu or Asp

<220>
<221>  VARIANT
<222>  (158)..(158)
<223>  Xaa can be Ile or Val

<220>
<221>  VARIANT
<222>  (159)..(159)
<223>  Xaa can be Met, Leu or Glu

<220>
<221>  VARIANT
<222>  (160)..(160)
<223>  Xaa can be Ile, Leu, Val or Met

<220>
<221>  VARIANT
<222>  (163)..(163)
<223>  Xaa can be Phe or Glu

<220>
<221>  VARIANT
<222>  (165)..(165)
<223>  Xaa can be Val or Ile

<220>
<221>  VARIANT
<222>  (168)..(168)
<223>  Xaa can be Thr, Val, Arg or Asn

<220>
<221>  VARIANT
<222>  (169)..(169)
<223>  Xaa can be Phe or Leu

<220>
<221>  VARIANT
<222>  (170)..(170)
<223>  Xaa can be Phe, Tyr or Glu

<220>
<221>  VARIANT
<222>  (172)..(172)
<223>  Xaa can be Tyr, Phe, Asn or Thr

<220>
<221>  VARIANT
<222>  (174)..(174)
<223>  Xaa can be Asn, Gln or Asp

<220>
<221>  VARIANT
<222>  (175)..(175)
<223>  Xaa can be Gln, Glu, Ser, Arg or absent

<220>
<221>  VARIANT
<222>  (176)..(176)
<223>  Xaa can be Pro, Asn or Ser

<220>
<221>  VARIANT
<222>  (177)..(177)
<223>  Xaa can be Asn, Gln, Thr or Asp

<220>
<221>  VARIANT
<222>  (178)..(178)
<223>  Xaa can be Ser, Pro or Gln

<220>
<221>  VARIANT
<222>  (179)..(179)
<223>  Xaa can be Arg or Thr

<220>
<221>  VARIANT
<222>  (180)..(180)
<223>  Xaa can be Met or Ile

<220>
<221>  VARIANT
<222>  (181)..(181)
<223>  Xaa can be Arg or Lys

<220>
<221>  VARIANT
<222>  (183)..(183)
<223>  Xaa can be Val or Ile

<220>
<221>  VARIANT
<222>  (184)..(184)
<223>  Xaa can be Ala or Cys

<220>
<221>  VARIANT
<222>  (192)..(192)
<223>  Xaa can be Ser, Ala or Thr

<220>
<221>  VARIANT
<222>  (193)..(193)
<223>  Xaa can be Asn, Ser or Gln

<220>
<221>  VARIANT
<222>  (194)..(194)
<223>  Xaa can be Asn, Gln or absent

<220>
<221>  VARIANT
<222>  (195)..(195)
<223>  Xaa can be Ser, Ala or Gln

<220>
<221>  VARIANT
<222>  (196)..(196)
<223>  Xaa can be Ser, Thr or absent

<220>
<221>  VARIANT
<222>  (197)..(197)
<223>  Xaa can be Ser, Gln or absent

<220>
<221>  VARIANT
<222>  (198)..(198)
<223>  Xaa can be Gln, Asn or absent

<220>
<221>  VARIANT
<222>  (199)..(199)
<223>  Xaa can be Asp, Glu, Thr, Ser or absent

<220>
<221>  VARIANT
<222>  (201)..(201)
<223>  Xaa can be Val, Pro or Ser

<220>
<221>  VARIANT
<222>  (203)..(203)
<223>  Xaa can be Thr or Val

<220>
<221>  VARIANT
<222>  (204)..(204)
<223>  Xaa can be Val or Ile

<220>
<221>  VARIANT
<222>  (205)..(205)
<223>  Xaa can be Ser or Ala

<220>
<221>  VARIANT
<222>  (206)..(206)
<223>  Xaa can be Cys or Gln

<220>
<221>  VARIANT
<222>  (209)..(209)
<223>  Xaa can be Leu or Met

<220>
<221>  VARIANT
<222>  (211)..(211)
<223>  Xaa can be Arg, Cys or Ala

<220>
<221>  VARIANT
<222>  (213)..(213)
<223>  Xaa can be Thr, Ala or Ser

<220>
<221>  VARIANT
<222>  (214)..(214)
<223>  Xaa can be Pro or Ser

<220>
<221>  VARIANT
<222>  (217)..(217)
<223>  Xaa can be Glu, Asp, Asn or Ser

<220>
<221>  VARIANT
<222>  (219)..(219)
<223>  Xaa can be Thr, Ile or Leu

<220>
<221>  VARIANT
<222>  (220)..(220)
<223>  Xaa can be Tyr or Phe

<220>
<221>  VARIANT
<222>  (225)..(225)
<223>  Xaa can be Ser, Thr or Asn

<220>
<221>  VARIANT
<222>  (226)..(226)
<223>  Xaa can be Val or Ile

<220>
<221>  VARIANT
<222>  (228)..(228)
<223>  Xaa can be Ser or Gln

<220>
<221>  VARIANT
<222>  (229)..(229)
<223>  Xaa can be Lys or Arg

<220>
<221>  VARIANT
<222>  (231)..(231)
<223>  Xaa can be Lys or Arg

<220>
<221>  VARIANT
<222>  (232)..(232)
<223>  Xaa can be Pro or Ala

<220>
<221>  VARIANT
<222>  (234)..(234)
<223>  Xaa can be Ser or Thr

<220>
<221>  VARIANT
<222>  (235)..(235)
<223>  Xaa can be Leu or Val

<220>
<221>  VARIANT
<222>  (237)..(237)
<223>  Xaa can be Ile, Val or Asn

<220>
<221>  VARIANT
<222>  (238)..(238)
<223>  Xaa can be Leu or Ile

<220>
<221>  VARIANT
<222>  (239)..(239)
<223>  Xaa can be Thr or Pro

<220>
<221>  VARIANT
<222>  (240)..(240)
<223>  Xaa can be Leu, Ile or Val

<220>
<221>  VARIANT
<222>  (242)..(242)
<223>  Xaa can be Glu, Val, Thr or Ser

<220>
<221>  VARIANT
<222>  (243)..(243)
<223>  Xaa can be Leu or Met

<220>
<221>  VARIANT
<222>  (244)..(244)
<223>  Xaa can be Thr or Ser

<220>
<221>  VARIANT
<222>  (248)..(248)
<223>  Xaa can be Phr, Val or Ala

<220>
<221>  VARIANT
<222>  (250)..(250)
<223>  Xaa can be Val, Ile, Ala, Ser or Leu

<220>
<221>  VARIANT
<222>  (251)..(251)
<223>  Xaa can be Pro, Ser or Leu

<220>
<221>  VARIANT
<222>  (252)..(252)
<223>  Xaa can be Ile or Leu

<220>
<221>  VARIANT
<222>  (253)..(253)
<223>  Xaa can be Asp, Glu, Lys, Gln or Ser

<220>
<221>  VARIANT
<222>  (254)..(254)
<223>  Xaa can be Ser, Gln, Met, Lys or Gly

<220>
<221>  VARIANT
<222>  (255)..(255)
<223>  Xaa can be Leu or Met

<220>
<221>  VARIANT
<222>  (256)..(256)
<223>  Xaa can be Phe, Tyr, Met, Ile or Gly

<220>
<221>  VARIANT
<222>  (257)..(257)
<223>  Xaa can be Thr, Val, Leu or Ile

<220>
<221>  VARIANT
<222>  (258)..(258)
<223>  Xaa can be Ala, Asp, Gly or Ser

<220>
<221>  VARIANT
<222>  (259)..(259)
<223>  Xaa can be Gln or Pro

<220>
<221>  VARIANT
<222>  (260)..(260)
<223>  Xaa can be Asn, Ser or Asp

<220>
<221>  VARIANT
<222>  (261)..(261)
<223>  Xaa can be Asn, Glu, Ser, His or Ala

<220>
<221>  VARIANT
<222>  (262)..(262)
<223>  Xaa can be Val, Asn, Gly, Ala or Ser

<220>
<221>  VARIANT
<222>  (263)..(263)
<223>  Xaa can be Leu, Asn, Ile, Phe or Gln

<220>
<221>  VARIANT
<222>  (264)..(264)
<223>  Xaa can be Gln, Val, Met or Ser

<220>
<221>  VARIANT
<222>  (267)..(267)
<223>  Xaa can be Cys, Pro or Phe

<220>
<221>  VARIANT
<222>  (272)..(272)
<223>  Xaa can be Cys or Val

<220>
<221>  VARIANT
<222>  (273)..(273)
<223>  Xaa can be Thr or Leu

<220>
<221>  VARIANT
<222>  (274)..(274)
<223>  Xaa can be Leu, Thr or Ile

<220>
<221>  VARIANT
<222>  (277)..(277)
<223>  Xaa can be Glu, Thr, Val, Gln or Arg

<220>
<221>  VARIANT
<222>  (279)..(279)
<223>  Xaa can be Gln, Leu or Val

<220>
<221>  VARIANT
<222>  (283)..(283)
<223>  Xaa can be Gln or Pro

<220>
<221>  VARIANT
<222>  (284)..(284)
<223>  Xaa can be Leu, Thr, Ala or Val

<220>
<221>  VARIANT
<222>  (285)..(285)
<223>  Xaa can be Leu, Val, Ser or Thr

<220>
<221>  VARIANT
<222>  (286)..(286)
<223>  Xaa can be Pro, Ser, Ala or Leu

<220>
<221>  VARIANT
<222>  (287)..(287)
<223>  Xaa can be Ser, Thr, Val or Gly

<220>
<221>  VARIANT
<222>  (288)..(288)
<223>  Xaa can be Gly, Ala, Gln, Asn or His

<220>
<221>  VARIANT
<222>  (289)..(289)
<223>  Xaa can be Ile, Val or Leu

<220>
<221>  VARIANT
<222>  (290)..(290)
<223>  Xaa can be Cye, Phe or Ala

<220>
<221>  VARIANT
<222>  (291)..(291)
<223>  Xaa can be Ala, Ser, Thr, Lys or Arg

<220>
<221>  VARIANT
<222>  (292)..(292)
<223>  Xaa can be Phe, Tyr, Ile or Val

<220>
<221>  VARIANT
<222>  (295)..(295)
<223>  Xaa can be Arg, Thr, Asp or Lys

<220>
<221>  VARIANT
<222>  (296)..(296)
<223>  Xaa can be Val, Thr, Leu, Ile or Ser

<220>
<221>  VARIANT
<222>  (297)..(297)
<223>  Xaa can be Thr, Val, Ile, Tyr or Asn

<220>
<221>  VARIANT
<222>  (298)..(298)
<223>  Xaa can be Ala, Gly, His or absent

<220>
<221>  VARIANT
<222>  (299)..(299)
<223>  Xaa can be Glu, Asn, Gln, Ile, Ala or absent

<220>
<221>  VARIANT
<222>  (300)..(300)
<223>  Xaa can be Thr, Ser, Gln or absent

<220>
<221>  VARIANT
<222>  (301)..(301)
<223>  Xaa can be Asp, Gln, Ser or absent

<220>
<221>  VARIANT
<222>  (313)..(313)
<223>  Xaa can be Asp, Arg or absent

<220>
<221>  VARIANT
<222>  (314)..(314)
<223>  Xaa can be Arg or absent

<220>
<221>  VARIANT
<222>  (316)..(316)
<223>  Xaa can be Asp, His or absent

<220>
<221>  VARIANT
<222>  (317)..(317)
<223>  Xaa can be Lys, Gln, Pro, Asn or absent

<220>
<221>  VARIANT
<222>  (318)..(318)
<223>  Xaa can be Trp, Asn, Leu, Tyr or absent

<220>
<221>  VARIANT
<222>  (319)..(319)
<223>  Xaa can be His, Val, Thr or Gly

<220>
<221>  VARIANT
<222>  (320)..(320)
<223>  Xaa can be Met, Leu, Val or Ile

<220>
<221>  VARIANT
<222>  (321)..(321)
<223>  Xaa can be Gln or Asn

<220>
<221>  VARIANT
<222>  (323)..(323)
<223>  Xaa can be Gln, Thr, Lys or Ala

<220>
<221>  VARIANT
<222>  (324)..(324)
<223>  Xaa can be Asn, Tyr, Ser or Glu

<220>
<221>  VARIANT
<222>  (325)..(325)
<223>  Xaa can be Leu, Pro, Gln, Ile or Val

<220>
<221>  VARIANT
<222>  (326)..(326)
<223>  Xaa can be Asn, Ser or Asp

<220>
<221>  VARIANT
<222>  (327)..(327)
<223>  Xaa can be Gly or Trp

<220>
<221>  VARIANT
<222>  (328)..(328)
<223>  Xaa can be Thr, Ala, Asn or Lys

<220>
<221>  VARIANT
<222>  (329)..(329)
<223>  Xaa can be Thr, Ser, Gln, Asp or Pro

<220>
<221>  VARIANT
<222>  (330)..(330)
<223>  Xaa can be Tyr or Phe

<220>
<221>  VARIANT
<222>  (331)..(331)
<223>  Xaa can be Asp, His or Met

<220>
<221>  VARIANT
<222>  (332)..(332)
<223>  Xaa can be Pro or Ala

<220>
<221>  VARIANT
<222>  (333)..(333)
<223>  Xaa can be Tre or Phe

<220>
<221>  VARIANT
<222>  (334)..(334)
<223>  Xaa can be Asp, Glu or absent

<220>
<221>  VARIANT
<222>  (335)..(335)
<223>  Xaa can be Asp or Glu

<220>
<221>  VARIANT
<222>  (336)..(336)
<223>  Xaa can be Val, Ile, Ser or Gly

<220>
<221>  VARIANT
<222>  (339)..(339)
<223>  Xaa can be Pro or Val

<220>
<221>  VARIANT
<222>  (340)..(340)
<223>  Xaa can be Leu, Val or Ile

<220>
<221>  VARIANT
<222>  (342)..(342)
<223>  Xaa can be Thr, Ala or Phe

<220>
<221>  VARIANT
<222>  (343)..(343)
<223>  Xaa can be Pro, Gln or Ile

<220>
<221>  VARIANT
<222>  (345)..(345)
<223>  Xaa can be Phe or Leu

<220>
<221>  VARIANT
<222>  (346)..(346)
<223>  Xaa can be Lys, Ser, Val or Gly

<220>
<221>  VARIANT
<222>  (347)..(347)
<223>  Xaa can be Gly, Glu or Lys

<220>
<221>  VARIANT
<222>  (348)..(348)
<223>  Xaa can be Val, Ile, Thr, Lys or Cys

<220>
<221>  VARIANT
<222>  (349)..(349)
<223>  Xaa can be Val, Leu, Ile or Asp

<220>
<221>  VARIANT
<222>  (350)..(350)
<223>  Xaa can be Phe, Tyr, Gln or Trp

<220>
<221>  VARIANT
<222>  (351)..(351)
<223>  Xaa can be Gly or His

<220>
<221>  VARIANT
<222>  (352)..(352)
<223>  Xaa can be Val, Ile or Met

<220>
<221>  VARIANT
<222>  (353)..(353)
<223>  Xaa can be Ala, Leu, Asn or Arg

<220>
<221>  VARIANT
<222>  (354)..(354)
<223>  Xaa can be Ser, Thr, Ala, Ile or Met

<220>
<221>  VARIANT
<222>  (355)..(355)
<223>  Xaa can be Gln, Ser or Thr

<220>
<221>  VARIANT
<222>  (356)..(356)
<223>  Xaa can be Arg, Asp, Thr, Pro, Lys or Gln

<220>
<221>  VARIANT
<222>  (357)..(357)
<223>  Xaa can be Asn, Asp, Thr, Ala or Phe

<220>
<221>  VARIANT
<222>  (358)..(358)
<223>  Xaa can be Val, Arg, Asn, Pro or Gly

<220>
<221>  VARIANT
<222>  (359)..(359)
<223>  Xaa can be Gly, Arg, Ser, Ala, Asn, His or absent

<220>
<221>  VARIANT
<222>  (360)..(360)
<223>  Xaa can be Asn, Gly, Gly, Phe, Ser or Absent

<220>
<221>  VARIANT
<222>  (361)..(361)
<223>  Xaa can be Asp, Asn, Gln, Thr, Ser or absent

<220>
<221>  VARIANT
<222>  (362)..(362)
<223>  Xa can be Ala, Thr, Gln, Ser or absent

<220>
<221>  VARIANT
<222>  (363)..(363)
<223>  Xaa can be Pro, Gln, Val, Asp or absent

<220>
<221>  VARIANT
<222>  (364)..(364)
<223>  Xaa can be Gly, Glu, Asp, Ser or absent

<220>
<221>  VARIANT
<222>  (365)..(365)
<223>  Xaa can be Ser, Ala or Gly

<220>
<221>  VARIANT
<222>  (366)..(366)
<223>  Xaa can be Thr, Lys, Ser, Asp or absent

<220>
<221>  VARIANT
<222>  (367)..(367)
<223>  Xaa can be Arg, Asn, Ile, Pro or absent

<220>
<221>  VARIANT
<222>  (368)..(368)
<223>  Xaa can be Ala, Gly, Ile, Met or Gln

<220>
<221>  VARIANT
<222>  (369)..(369)
<223>  Xaa can be His, Lys, Arg or Thr

<220>
<221>  VARIANT
<222>  (370)..(370)
<223>  Xaa can be Glu, Gly, Lys, Arg, Ser or Gln

<220>
<221>  VARIANT
<222>  (371)..(371)
<223>  Xaa can be Ala, Val, Ile or Tyr

<220>
<221>  VARIANT
<222>  (372)..(372)
<223>  Xaa can be Val, Tyr, His, Thr or Asp

<220>
<221>  VARIANT
<222>  (373)..(373)
<223>  Xaa can be Ile or Val

<220>
<221>  VARIANT
<222>  (374)..(374)
<223>  Xaa can be Ser, Asn, Tyr, Ala, Gln or Asp

<220>
<221>  VARIANT
<222>  (375)..(375)
<223>  Xaa can be Thr or absent

<220>
<221>  VARIANT
<222>  (376)..(376)
<223>  Xaa can be Tyr, Thr, Gly, Gln or Asp

<220>
<221>  VARIANT
<222>  (377)..(377)
<223>  Xaa can be Ser, Asp, Val or Pro

<220>
<221>  VARIANT
<222>  (378)..(378)
<223>  Xaa can be Pro, Gly, Ala, Ser, Gln or Asp

<220>
<221>  VARIANT
<222>  (379)..(379)
<223>  Xaa can be Gln, Lys, Arg, Asp, Thr or Gly

<220>
<221>  VARIANT
<222>  (380)..(380)
<223>  Xaa can be Phe or Tyr

<220>
<221>  VARIANT
<222>  (381)..(381)
<223>  Xaa can be Val, Thr or Ala

<220>
<221>  VARIANT
<222>  (382)..(382)
<223>  Xaa is Pro

<220>
<221>  VARIANT
<222>  (383)..(383)
<223>  Xaa can be Lys or His

<220>
<221>  VARIANT
<222>  (384)..(384)
<223>  Xaa can be Lys or Ile

<220>
<221>  VARIANT
<222>  (386)..(386)
<223>  Xaa can be Ser, Arg or Thr

<220>
<221>  VARIANT
<222>  (387)..(387)
<223>  Xaa can be Val or Ile

<220>
<221>  VARIANT
<222>  (388)..(388)
<223>  Xaa can be Asn, Gly, Leu, Gln or His

<220>
<221>  VARIANT
<222>  (389)..(389)
<223>  Xaa can be Phe, Leu, Met, Tyr or Ala

<220>
<221>  VARIANT
<222>  (390)..(390)
<223>  Xaa can be Arg, His, Tyr, Glu, Thr, Asp or Asn

<220>
<221>  VARIANT
<222>  (391)..(391)
<223>  Xaa can be Ser, Thr, Asn, Glu or Gly

<220>
<221>  VARIANT
<222>  (392)..(392)
<223>  Xaa can be Asn, Ile, Glu, Asp, Ala or Val

<220>
<221>  VARIANT
<222>  (393)..(393)
<223>  Xaa can be Thr, Asp, Phe or absent

<220>
<221>  VARIANT
<222>  (394)..(394)
<223>  Xaa can be Asp, Thr, Ser, Tyr, Asn or absent

<220>
<221>  VARIANT
<222>  (395)..(395)
<223>  Xaa can be Asn, Glu, Asp, Arg, His or absent

<220>
<221>  VARIANT
<222>  (396)..(396)
<223>  Xaa can be Asp, Ala, Pro or Gly

<220>
<221>  VARIANT
<222>  (397)..(397)
<223>  Xaa can be Phe, Val, Asn, Thr or Ser

<220>
<221>  VARIANT
<222>  (398)..(398)
<223>  Xaa can be Gln, Arg, Val, Glu or Gly

<220>
<221>  VARIANT
<222>  (399)..(399)
<223>  Xaa can be Pro, Thr, Ala or absent

<220>
<221>  VARIANT
<222>  (400)..(400)
<223>  Xaa can be Leu, Asn, Gly or absent

<220>
<221>  VARIANT
<222>  (401)..(401)
<223>  Xaa can be Gln or absent

<220>
<221>  VARIANT
<222>  (402)..(402)
<223>  Xaa can be Pro, Gln, Asn or absent

<220>
<221>  VARIANT
<222>  (403)..(403)
<223>  Xaa can be Thr, Ser, Val, Gly, Asp or Asn

<220>
<221>  VARIANT
<222>  (404)..(404)
<223>  Caa can be Lys, Arg, Leu or Tyr

<220>
<221>  VARIANT
<222>  (405)..(405)
<223>  Xaa can be Phe, Ile or Val

<220>
<221>  VARIANT
<222>  (406)..(406)
<223>  Xaa can be Thr, Cys or Gly

<220>
<221>  VARIANT
<222>  (407)..(407)
<223>  Xaa can be Pro, Ser, Thr or Val

<220>
<221>  VARIANT
<222>  (408)..(408)
<223>  Xaa can be Val, Ile or Leu

<220>
<221>  VARIANT
<222>  (409)..(409)
<223>  Xaa can be Gly, Glu or Ser

<220>
<221>  VARIANT
<222>  (410)..(410)
<223>  Xaa can be Ile, Val, Met or Trp

<220>
<221>  VARIANT
<222>  (411)..(411)
<223>  Xaa can be Asn, Ala, Gly, Ile or Leu

<220>
<221>  VARIANT
<222>  (412)..(412)
<223>  Xaa can be Asp, Gln or Ser

<220>
<221>  VARIANT
<222>  (413)..(413)
<223>  Xaa can be Asp, Asn, Pro or Gln

<220>
<221>  VARIANT
<222>  (414)..(414)
<223>  Xaa can be Gly, Glu, Pro or absent

<220>
<221>  VARIANT
<222>  (415)..(415)
<223>  Xaa can be Asp, Asn, Gly, Ser or absent

<220>
<221>  misc_feature
<222>  (416)..(416)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (417)..(417)
<223>  Xaa can be Thr, Gly, Pro or absent

<220>
<221>  VARIANT
<222>  (418)..(418)
<223>  Xaa can be His, Pro, Ser or absent

<220>
<221>  VARIANT
<222>  (419)..(419)
<223>  Xaa can be Arg, Ala Gly or absent

<220>
<221>  VARIANT
<222>  (420)..(420)
<223>  Xaa can be Asn, Pro, Thr, Ser or absent

<220>
<221>  VARIANT
<222>  (421)..(421)
<223>  Xaa can be Pro, Asp, Gu, Lys or Gln

<220>
<221>  VARIANT
<222>  (422)..(422)
<223>  Xaa can be Phe, Trp, Pro, Val or Ile

<220>
<221>  VARIANT
<222>  (423)..(423)
<223>  Xaa can be Arg, Gln, His, Asn or Asp

<220>
<221>  VARIANT
<222>  (424)..(424)
<223>  Xaa can be Gln, Pro or Leu

<220>
<221>  VARIANT
<222>  (426)..(426)
<223>  Xaa can be Glu, Val, Ala or Lys

<220>
<221>  VARIANT
<222>  (427)..(427)
<223>  Xaa can be Leu or Ile

<220>
<221>  VARIANT
<222>  (429)..(429)
<223>  Xaa can be Asp, His, Ser, Arg or Asn

<220>
<221>  VARIANT
<222>  (431)..(431)
<223>  Xaa can be Ser, Ala, Pro or Gly

<220>
<221>  VARIANT
<222>  (432)..(432)
<223>  Xaa can be Gly or Ser

<220>
<221>  VARIANT
<222>  (433)..(433)
<223>  Xaa can be Leu, Ala, His, Arg, Thr or Ser

<220>
<221>  VARIANT
<222>  (434)..(434)
<223>  Xaa can be Leu, Asn or Ile

<220>
<221>  VARIANT
<222>  (435)..(435)
<223>  Xaa can be Thr, Ala or Ser

<220>
<221>  VARIANT
<222>  (436)..(436)
<223>  Xaa can be Leu, His, Glu or Gln

<220>
<221>  VARIANT
<222>  (437)..(437)
<223>  Xaa can be Asn or Ala

<220>
<221>  VARIANT
<222>  (438)..(438)
<223>  Xaa can be Met, Thr, Val or Ala

<220>
<221>  VARIANT
<222>  (439)..(439)
<223>  Xaa can be Asn, His or Gln

<220>
<221>  VARIANT
<222>  (443)..(443)
<223>  Xaa can be Pro, Ala or Ser

<220>
<221>  VARIANT
<222>  (444)..(444)
<223>  Xaa can be Val or Ile

<220>
<221>  VARIANT
<222>  (445)..(445)
<223>  Xaa can be Ala, Tyr or  Phe

<220>
<221>  VARIANT
<222>  (447)..(447)
<223>  Xaa can be Asn, Thr, Ala or Pro

<220>
<221>  VARIANT
<222>  (448)..(448)
<223>  Xaa can be Phe or Gly

<220>
<221>  VARIANT
<222>  (449)..(449)
<223>  Xaa can be Pro or Phe

<220>
<221>  VARIANT
<222>  (452)..(452)
<223>  Xaa can be Gln, Arg, Ala or Val

<220>
<221>  VARIANT
<222>  (453)..(453)
<223>  Xaa can be Leu or Ile

<220>
<221>  VARIANT
<222>  (454)..(454)
<223>  Xaa can be Leu or Val

<220>
<221>  VARIANT
<222>  (455)..(455)
<223>  Xaa can be Phe or Tyr

<220>
<221>  VARIANT
<222>  (457)..(457)
<223>  Xaa can be Arg, Met or Val

<220>
<221>  misc_feature
<222>  (458)..(458)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (459)..(459)
<223>  Xaa can be Phe, Arg, Ile, Thr, Asp, Ala or Lys

<220>
<221>  VARIANT
<222>  (460)..(460)
<223>  Xaa can be Val, Met, Phe or Met

<220>
<221>  VARIANT
<222>  (462)..(462)
<223>  Xaa can be Cys, Ser, Gly or Ile

<220>
<221>  VARIANT
<222>  (463)..(463)
<223>  Xaa can be Ser, Val, Ala, Cys or Pro

<220>
<221>  VARIANT
<222>  (464)..(464)
<223>  Xaa can be Gly, Gln, Ser or Asn

<220>
<221>  VARIANT
<222>  (465)..(465)
<223>  Xaa can be Gly, Asn or Ala

<220>
<221>  VARIANT
<222>  (466)..(466)
<223>  Xaa can be Tyr, Leu, Arg or absent

<220>
<221>  VARIANT
<222>  (467)..(467)
<223>  Xaa can be Asp, Gln, Gly, Pro, Ser or absent

<220>
<221>  VARIANT
<222>  (468)..(468)
<223>  Xaa can be Gly or absent

<220>
<221>  VARIANT
<222>  (470)..(470)
<223>  Xaa can be Gln, Asp, Ser, Asn, Gly, Pro or absent

<220>
<221>  misc_feature
<222>  (471)..(471)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (472)..(472)
<223>  Xaa can be Ile, Phe, Gln, Asp, Ser or Asn

<220>
<221>  VARIANT
<222>  (473)..(473)
<223>  Xaa can be Val, Ile or Leu

<220>
<221>  VARIANT
<222>  (474)..(474)
<223>  Xaa can be Asp or Pro

<220>
<221>  VARIANT
<222>  (476)..(476)
<223>  Xaa can be Leu or Thr

<220>
<221>  misc_feature
<222>  (477)..(477)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (479)..(479)
<223>  Xaa can be Ile or Leu

<220>
<221>  VARIANT
<222>  (481)..(481)
<223>  Xaa can be Trp, Phe or Tyr

<220>
<221>  VARIANT
<222>  (482)..(482)
<223>  Xaa can be Ile or Val

<220>
<221>  VARIANT
<222>  (483)..(483)
<223>  Xaa can be Gln, Asn, Thr or Ser

<220>
<221>  VARIANT
<222>  (484)..(484)
<223>  Xaa can be His or Tyr

<220>
<221>  VARIANT
<222>  (485)..(485)
<223>  Xaa can be Phe or Leu

<220>
<221>  VARIANT
<222>  (486)..(486)
<223>  Xaa can be Tyr, Val or Ala

<220>
<221>  VARIANT
<222>  (487)..(487)
<223>  Xaa can be Gln, Asn or Ser

<220>
<221>  VARIANT
<222>  (489)..(489)
<223>  Xaa can be Ser, Ala or Gln

<220>
<221>  VARIANT
<222>  (492)..(492)
<223>  Xaa can be Ser, Ala or Thr

<220>
<221>  VARIANT
<222>  (493)..(493)
<223>  Xaa can be Gln, Arg, Met or Val

<220>
<221>  VARIANT
<222>  (494)..(494)
<223>  Xaa can be Ser, Ala or Gly

<220>
<221>  VARIANT
<222>  (495)..(495)
<223>  Xaa can be Asp, Ala or Glu

<220>
<221>  VARIANT
<222>  (496)..(496)
<223>  Xaa can be Val or Ala

<220>
<221>  VARIANT
<222>  (499)..(499)
<223>  Xaa can be Leu or Ile

<220>
<221>  VARIANT
<222>  (500)..(500)
<223>  Xaa can be Arg or His

<220>
<221>  VARIANT
<222>  (501)..(501)
<223>  Xaa can be Tyr or Phe

<220>
<221>  VARIANT
<222>  (503)..(503)
<223>  Xaa can be Asn or Asp

<220>
<221>  VARIANT
<222>  (507)..(507)
<223>  Xaa can be Gly, His or Asn

<220>
<221>  VARIANT
<222>  (509)..(509)
<223>  Xaa can be Thr, Asn or Val

<220>
<221>  VARIANT
<222>  (510)..(510)
<223>  Xaa can be Leu or Ile

<220>
<221>  VARIANT
<222>  (511)..(511)
<223>  Xaa can be Phe or Gly

<220>
<221>  VARIANT
<222>  (513)..(513)
<223>  Xaa can be Ala, Cys or Phe

<220>
<221>  VARIANT
<222>  (515)..(515)
<223>  Xaa can be Leu or Ala

<220>
<221>  VARIANT
<222>  (516)..(516)
<223>  Xaa can be His or Tyr

<220>
<221>  VARIANT
<222>  (517)..(517)
<223>  Xaa can be Arg, Lys or Pro

<220>
<221>  VARIANT
<222>  (518)..(518)
<223>  Xaa can be Ser, Glu, Gly or Asp

<220>
<221>  VARIANT
<222>  (520)..(520)
<223>  Xaa can be Phe or Tyr

<220>
<221>  VARIANT
<222>  (521)..(521)
<223>  Xaa can be Ile, Val, Met or Leu

<220>
<221>  VARIANT
<222>  (523)..(523)
<223>  Xaa can be Val or Cys

<220>
<221>  VARIANT
<222>  (524)..(524)
<223>  Xaa can be Ala, Ser or Val

<220>
<221>  VARIANT
<222>  (525)..(525)
<223>  Xaa can be His or Pro

<220>
<221>  VARIANT
<222>  (526)..(526)
<223>  Xaa can be Asn or absent

<220>
<221>  VARIANT
<222>  (527)..(527)
<223>  Xaa can be Gly, Ser or absent

<220>
<221>  VARIANT
<222>  (528)..(528)
<223>  Xaa can be Ser, Thr, Val or Ala

<220>
<221>  VARIANT
<222>  (529)..(529)
<223>  Xaa can be Gly or Ser

<220>
<221>  VARIANT
<222>  (530)..(530)
<223>  Xaa can be Asp, Ala, Asn, Gln or Ser

<220>
<221>  VARIANT
<222>  (531)..(531)
<223>  Xaa can be Tyr, Asn, His or Gly

<220>
<221>  VARIANT
<222>  (532)..(532)
<223>  Xaa can be Pro or Asp

<220>
<221>  VARIANT
<222>  (533)..(533)
<223>  Xaa can be Leu, Ile or Gln

<220>
<221>  VARIANT
<222>  (534)..(534)
<223>  Xaa can be Val, Thr or Gln

<220>
<221>  VARIANT
<222>  (535)..(535)
<223>  Xaa can be Val, Ile or Leu

<220>
<221>  VARIANT
<222>  (537)..(537)
<223>  Xaa can be Ala, Pro, Ile or Leu

<220>
<221>  VARIANT
<222>  (540)..(540)
<223>  Xaa can e Tyr, His or Val

<220>
<221>  VARIANT
<222>  (542)..(542)
<223>  Xaa can be Arg, Thr, Leu or Val

<220>
<221>  VARIANT
<222>  (544)..(544)
<223>  Xaa can be Asp, Glu, Ile or Val

<220>
<221>  VARIANT
<222>  (545)..(545)
<223>  Xaa can be Ser or Ala

<220>
<221>  VARIANT
<222>  (548)..(548)
<223>  Xaa can be Asn or Ser

<220>
<221>  VARIANT
<222>  (549)..(549)
<223>  Xaa can be Gln or Arg

<220>
<221>  VARIANT
<222>  (552)..(552)
<223>  Xaa can be Ser, Thr or Gln

<220>
<221>  VARIANT
<222>  (554)..(554)
<223>  Xaa can be Ala, Thr or Lys

<220>
<221>  VARIANT
<222>  (556)..(556)
<223>  Xaa can be Met or Val

<220>
<221>  VARIANT
<222>  (558)..(558)
<223>  Xaa can be Thr or Asn

<220>
<221>  VARIANT
<222>  (559)..(559)
<223>  Xaa can be Gly, Thr or Ala

<220>
<221>  VARIANT
<222>  (560)..(560)
<223>  Xaa can be Asn, Gln, Thr, Gly or Ser

<220>
<221>  VARIANT
<222>  (561)..(561)
<223>  Xaa can be Gly, Pro, Thr or Ser

<220>
<221>  VARIANT
<222>  (562)..(562)
<223>  Xaa can be Arg, Val or Ala

<220>
<221>  VARIANT
<222>  (564)..(564)
<223>  Xaa can be Arg, Gly or absent

<220>
<221>  VARIANT
<222>  (565)..(565)
<223>  Xaa can be Ala, Val, Asp or Arg

<220>
<221>  VARIANT
<222>  (566)..(566)
<223>  Xaa can be Gln, Val or Leu

<220>
<221>  VARIANT
<222>  (568)..(568)
<223>  Xaa can be Ile, Val, Leu or absent

<220>
<221>  VARIANT
<222>  (571)..(571)
<223>  Xaa can be Ser, Ile or absent

<400>  70

Met Xaa Met Ala Ser Xaa Asp Ala Xaa Xaa Xaa Xaa Xaa Gly Xaa Ser 
1               5                   10                  15      


Xaa Ala Xaa Xaa Leu Val Pro Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Pro Val Xaa Gly Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Gly Gln 
        35                  40                  45              


Xaa Asn Xaa Ile Asp Pro Trp Ile Xaa Xaa Asn Xaa Val Gln Xaa Pro 
    50                  55                  60                  


Xaa Gly Glu Phe Thr Xaa Ser Pro Xaa Asn Xaa Pro Gly Xaa Xaa Leu 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Leu Gly Pro Xaa Leu Asn Pro Xaa Leu Xaa His Leu 
                85                  90                  95      


Xaa Xaa Met Tyr Asn Gly Xaa Xaa Gly Xaa Xaa Xaa Val Xaa Xaa Xaa 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Xaa Ala Gly Lys Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Pro Pro Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa Thr Xaa 
    130                 135                 140                 


Xaa Pro His Xaa Xaa Xaa Asp Val Arg Xaa Leu Xaa Pro Xaa Xaa Xaa 
145                 150                 155                 160 


Pro Leu Xaa Asp Xaa Arg Asn Xaa Xaa Xaa His Xaa Asn Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Met Leu Tyr Thr Pro Leu Arg Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa Phe Xaa Xaa Xaa Xaa Arg Val 
        195                 200                 205             


Xaa Thr Xaa Pro Xaa Xaa Asp Phe Xaa Phe Xaa Xaa Leu Val Pro Pro 
    210                 215                 220                 


Xaa Xaa Glu Xaa Xaa Thr Xaa Xaa Phe Xaa Xaa Pro Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Asn Ser Arg Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Gln Xaa Gln Asn Gly Arg Xaa 
            260                 265                 270         


Xaa Xaa Asp Gly Xaa Leu Xaa Gly Thr Thr Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Arg Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Ser Pro 
    290                 295                 300                 


Asp Ser Thr Asp Ser Ala Pro Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Pro Ala Xaa Xaa Gly Xaa Xaa Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp Xaa Xaa Pro Xaa Tyr Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Ala Pro Xaa Xaa Xaa Pro Xaa Xaa 
        435                 440                 445             


Xaa Gly Glu Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Pro Gln Glu 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Ala Pro Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Ala Leu Xaa Xaa Xaa Val Xaa Pro Asp Thr Xaa Arg Xaa Xaa Xaa Glu 
            500                 505                 510         


Xaa Lys Xaa Xaa Xaa Xaa Gly Xaa Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Asn Gly Xaa Phe Xaa Phe Xaa 
    530                 535                 540                 


Xaa Trp Val Xaa Xaa Phe Tyr Xaa Leu Xaa Pro Xaa Gly Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Arg Xaa Xaa Xaa Gly Xaa Arg Arg Xaa 
                565                 570     


<210>  71
<211>  539
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acid sequence of S(GI.1)+P(GII.12) fusion VP1

<400>  71

Met Met Met Ala Ser Lys Asp Ala Thr Ser Ser Val Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ala Gly Gln Leu Val Pro Glu Val Asn Ala Ser Asp Pro Leu Ala 
            20                  25                  30          


Met Asp Pro Val Ala Gly Ser Ser Thr Ala Val Ala Thr Ala Gly Gln 
        35                  40                  45              


Val Asn Pro Ile Asp Pro Trp Ile Ile Asn Asn Phe Val Gln Ala Pro 
    50                  55                  60                  


Gln Gly Glu Phe Thr Ile Ser Pro Asn Asn Thr Pro Gly Asp Val Leu 
65                  70                  75                  80  


Phe Asp Leu Ser Leu Gly Pro His Leu Asn Pro Phe Leu Leu His Leu 
                85                  90                  95      


Ser Gln Met Tyr Asn Gly Trp Val Gly Asn Met Arg Val Arg Ile Met 
            100                 105                 110         


Leu Ala Gly Asn Ala Phe Thr Ala Gly Lys Ile Ile Val Ser Cys Ile 
        115                 120                 125             


Pro Pro Gly Phe Gly Ser His Asn Leu Thr Ile Ala Gln Ala Thr Leu 
    130                 135                 140                 


Phe Pro His Val Ile Ala Asp Val Arg Thr Leu Asp Pro Ile Glu Val 
145                 150                 155                 160 


Pro Leu Glu Asp Val Arg Asn Val Leu Phe His Asn Asn Asp Arg Asn 
                165                 170                 175     


Gln Gln Thr Met Arg Leu Val Cys Met Leu Tyr Thr Pro Leu Arg Thr 
            180                 185                 190         


Gly Gly Gly Thr Gly Asp Ser Phe Val Val Ala Gly Arg Val Met Thr 
        195                 200                 205             


Cys Pro Ser Pro Asp Phe Asn Phe Leu Phe Leu Val Pro Pro Thr Val 
    210                 215                 220                 


Glu Ser Lys Thr Lys Pro Phe Thr Leu Pro Ile Leu Thr Ile Gly Glu 
225                 230                 235                 240 


Leu Thr Asn Ser Arg Phe Pro Val Pro Ile Asp Glu Leu Tyr Thr Ser 
                245                 250                 255     


Pro Asn Glu Ser Leu Val Val Gln Pro Gln Asn Gly Arg Cys Ala Leu 
            260                 265                 270         


Asp Gly Glu Leu Gln Gly Thr Thr Gln Leu Leu Pro Thr Ala Ile Cys 
        275                 280                 285             


Ser Phe Arg Gly Arg Ile Asn Gln Lys Val Ser Gly Glu Asn His Val 
    290                 295                 300                 


Trp Asn Met Gln Val Thr Asn Ile Asp Gly Thr Pro Phe Asp Pro Thr 
305                 310                 315                 320 


Glu Asp Val Pro Ala Pro Leu Gly Thr Pro Asp Phe Ser Gly Lys Leu 
                325                 330                 335     


Phe Gly Val Leu Ser Gln Arg Asp His Asp Asn Ala Cys Arg Ser His 
            340                 345                 350         


Asp Ala Val Ile Ala Thr Asn Ser Ala Lys Phe Thr Pro Lys Leu Gly 
        355                 360                 365             


Ala Ile Gln Ile Gly Thr Trp Glu Gln Asp Asp Val His Ile Asn Gln 
    370                 375                 380                 


Pro Thr Lys Phe Thr Pro Val Gly Leu Phe Glu Ser Glu Gly Phe Asn 
385                 390                 395                 400 


Gln Trp Thr Leu Pro Asn Tyr Ser Gly Ala Leu Thr Leu Asn Met Gly 
                405                 410                 415     


Leu Ala Pro Pro Val Ala Pro Thr Phe Pro Gly Glu Gln Ile Leu Phe 
            420                 425                 430         


Phe Arg Ser His Ile Pro Leu Lys Gly Gly Val Ala Asp Pro Val Ile 
        435                 440                 445             


Asp Cys Leu Leu Pro Gln Glu Trp Ile Gln His Leu Tyr Gln Glu Ser 
    450                 455                 460                 


Ala Pro Ser Gln Thr Asp Val Ala Leu Ile Arg Phe Thr Asn Pro Asp 
465                 470                 475                 480 


Thr Gly Arg Val Leu Phe Glu Ala Lys Leu His Arg Ser Gly Tyr Ile 
                485                 490                 495     


Thr Val Ala Asn Thr Gly Ser Arg Pro Ile Val Val Pro Ala Asn Gly 
            500                 505                 510         


Tyr Phe Arg Phe Asp Ser Trp Val Asn Gln Phe Tyr Ser Leu Ala Pro 
        515                 520                 525             


Met Gly Thr Gly Asn Gly Arg Arg Arg Val Gln 
    530                 535                 


<210>  72
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  IF-NoV(US68)VP1(ORF2).c

<400>  72
tcgtgcttcg gcaccagtac aatgatgatg gcgtctaagg acgctacat                   49


<210>  73
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  IF-NoV(US68)VP1(ORF2).r

<400>  73
actaaagaaa ataggccttt atcggcgcag accaagccta cctcttgccg agctggcag        59


<210>  74
<211>  4540
<212>  DNA
<213>  Artificial

<220>
<223>  Construct 1190

<400>  74
tggcaggata tattgtggtg taaacaaatt gacgcttaga caacttaata acacattgcg       60

gacgttttta atgtactgaa ttaacgccga atcccgggct ggtatattta tatgttgtca      120

aataactcaa aaaccataaa agtttaagtt agcaagtgtg tacattttta cttgaacaaa      180

aatattcacc tactactgtt ataaatcatt attaaacatt agagtaaaga aatatggatg      240

ataagaacaa gagtagtgat attttgacaa caattttgtt gcaacatttg agaaaatttt      300

gttgttctct cttttcattg gtcaaaaaca atagagagag aaaaaggaag agggagaata      360

aaaacataat gtgagtatga gagagaaagt tgtacaaaag ttgtaccaaa atagttgtac      420

aaatatcatt gaggaatttg acaaaagcta cacaaataag ggttaattgc tgtaaataaa      480

taaggatgac gcattagaga gatgtaccat tagagaattt ttggcaagtc attaaaaaga      540

aagaataaat tatttttaaa attaaaagtt gagtcatttg attaaacatg tgattattta      600

atgaattgat gaaagagttg gattaaagtt gtattagtaa ttagaatttg gtgtcaaatt      660

taatttgaca tttgatcttt tcctatatat tgccccatag agtcagttaa ctcattttta      720

tatttcatag atcaaataag agaaataacg gtatattaat ccctccaaaa aaaaaaaacg      780

gtatatttac taaaaaatct aagccacgta ggaggataac aggatccccg taggaggata      840

acatccaatc caaccaatca caacaatcct gatgagataa cccactttaa gcccacgcat      900

ctgtggcaca tctacattat ctaaatcaca cattcttcca cacatctgag ccacacaaaa      960

accaatccac atctttatca cccattctat aaaaaatcac actttgtgag tctacacttt     1020

gattcccttc aaacacatac aaagagaaga gactaattaa ttaattaatc atcttgagag     1080

aaaatggaac gagctataca aggaaacgac gctagggaac aagctaacag tgaacgttgg     1140

gatggaggat caggaggtac cacttctccc ttcaaacttc ctgacgaaag tccgagttgg     1200

actgagtggc ggctacataa cgatgagacg aattcgaatc aagataatcc ccttggtttc     1260

aaggaaagct ggggtttcgg gaaagttgta tttaagagat atctcagata cgacaggacg     1320

gaagcttcac tgcacagagt ccttggatct tggacgggag attcggttaa ctatgcagca     1380

tctcgatttt tcggtttcga ccagatcgga tgtacctata gtattcggtt tcgaggagtt     1440

agtatcaccg tttctggagg gtcgcgaact cttcagcatc tctgtgagat ggcaattcgg     1500

tctaagcaag aactgctaca gcttgcccca atcgaagtgg aaagtaatgt atcaagagga     1560

tgccctgaag gtactcaaac cttcgaaaaa gaaagcgagt aagttaaaat gcttcttcgt     1620

ctcctattta taatatggtt tgttattgtt aattttgttc ttgtagaaga gcttaattaa     1680

tcgttgttgt tatgaaatac tatttgtatg agatgaactg gtgtaatgta attcatttac     1740

ataagtggag tcagaatcag aatgtttcct ccataactaa ctagacatga agacctgccg     1800

cgtacaattg tcttatattt gaacaactaa aattgaacat cttttgccac aactttataa     1860

gtggttaata tagctcaaat atatggtcaa gttcaataga ttaataatgg aaatatcagt     1920

tatcgaaatt cattaacaat caacttaacg ttattaacta ctaattttat atcatcccct     1980

ttgataaatg atagtacacc aattaggaag gagcatgctc gcctaggaga ttgtcgtttc     2040

ccgccttcag tttgcaagct gctctagccg tgtagccaat acgcaaaccg cctctccccg     2100

cgcgttggga attactagcg cgtgtcgaca agcttgcatg ccggtcaaca tggtggagca     2160

cgacacactt gtctactcca aaaatatcaa agatacagtc tcagaagacc aaagggcaat     2220

tgagactttt caacaaaggg taatatccgg aaacctcctc ggattccatt gcccagctat     2280

ctgtcacttt attgtgaaga tagtggaaaa ggaaggtggc tcctacaaat gccatcattg     2340

cgataaagga aaggccatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc     2400

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt     2460

ggattgatgt gataacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga     2520

tacagtctca gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa     2580

cctcctcgga ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga     2640

aggtggctcc tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc     2700

tgccgacagt ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga     2760

cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat atctccactg acgtaaggga     2820

tgacgcacaa tcccactatc cttcgcaaga cccttcctct atataaggaa gttcatttca     2880

tttggagagg tattaaaatc ttaataggtt ttgataaaag cgaacgtggg gaaacccgaa     2940

ccaaaccttc ttctaaactc tctctcatct ctcttaaagc aaacttctct cttgtctttc     3000

ttgcgtgagc gatcttcaac gttgtcagat cgtgcttcgg caccgcggat ggcgaaaaac     3060

gttgcgattt tcggcttatt gttttctctt cttgtgttgg ttccttctca gatcttcgcc     3120

tgcaggctcc tcagccaaaa cgacaccccc atctgtctat ccactggccc ctggatctgc     3180

tgcccaaact aactccatgg tgaccctggg atgcctggtc aagggctatt tccctgagcc     3240

agtgacagtg acctggaact ctggatccct gtccagcggt gtgcacacct tcccagctgt     3300

cctgcagtct gacctctaca ctctgagcag ctcagtgact gtcccctcca gcacctggcc     3360

cagcgagacc gtcacctgca acgttgccca cccggccagc agcaccaagg tggacaagaa     3420

aattgtgccc agggattgtg gttgtaagcc ttgcatatgt acagtcccag aagtatcatc     3480

tgtcttcatc ttccccccaa agcccaagga tgtgctcacc attactctga ctcctaaggt     3540

cacgtgtgtt gtggtagaca tcagcaagga tgatcccgag gtccagttca gctggtttgt     3600

agatgatgtg gaggtgcaca cagctcagac gcaaccccgg gaggagcagt tcaacagcac     3660

tttccgctca gtcagtgaac ttcccatcat gcaccaggac tggctcaatg gcaaggagcg     3720

atcgctcacc atcaccatca ccatcaccat caccattaaa ggcctatttt ctttagtttg     3780

aatttactgt tattcggtgt gcatttctat gtttggtgag cggttttctg tgctcagagt     3840

gtgtttattt tatgtaattt aatttctttg tgagctcctg tttagcaggt cgtcccttca     3900

gcaaggacac aaaaagattt taattttatt aaaaaaaaaa aaaaaaaaga ccgggaattc     3960

gatatcaagc ttatcgacct gcagatcgtt caaacatttg gcaataaagt ttcttaagat     4020

tgaatcctgt tgccggtctt gcgatgatta tcatataatt tctgttgaat tacgttaagc     4080

atgtaataat taacatgtaa tgcatgacgt tatttatgag atgggttttt atgattagag     4140

tcccgcaatt atacatttaa tacgcgatag aaaacaaaat atagcgcgca aactaggata     4200

aattatcgcg cgcggtgtca tctatgttac tagatctcta gagtctcaag cttggcgcgc     4260

ccacgtgact agtggcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     4320

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag     4380

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgctagagca     4440

gcttgagctt ggatcagatt gtcgtttccc gccttcagtt taaactatca gtgtttgaca     4500

ggatatattg gcgggtaaac ctaagagaaa agagcgttta                           4540


<210>  75
<211>  2976
<212>  DNA
<213>  Artificial

<220>
<223>  Expression cassette number 2720 from 2X35S promoter to NOS 
       terminator

<400>  75
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg atgatggcgt ctaaggacgc tacatcaagc gtggatggcg ctagtggcgc      960

tggtcagttg gtaccggagg ttaatgcttc tgaccctctt gcaatggatc ctgtagcagg     1020

ttcttcgaca gcagtcgcga ctgctggaca agttaatcct attgatccct ggataattaa     1080

taattttgtg caagcccccc aaggtgaatt tactatttcc ccaaataata cccccggtga     1140

tgttttgttt gatttgagtt tgggtcccca tcttaatcct ttcttgctcc atctatcaca     1200

aatgtataat ggttgggttg gtaacatgag agtcaggatt atgctagctg gtaatgcctt     1260

tactgcgggg aagataatag tttcctgcat accccctggt tttggttcac ataatcttac     1320

tatagcacaa gcaactctct ttccacatgt gattgctgat gttaggactc tagaccccat     1380

tgaggtgcct ttggaagatg ttaggaatgt tctctttcat aataatgata gaaatcaaca     1440

aaccatgcgc cttgtgtgca tgctgtacac ccccctccgc actggtggtg gtactggtga     1500

ttcttttgta gttgcagggc gagttatgac ttgccccagt cctgatttta atttcttgtt     1560

tttagtccct cctacggtgg agcagaaaac caggcccttc acactcccaa atctgccatt     1620

gagttctctg tctaactcac gtgcccctct cccaatcagt agtatgggca tttccccaga     1680

caatgtccag agtgtgcagt tccaaaatgg tcggtgtact ctggatggcc gcctggttgg     1740

caccacccca gtttcattgt cacatgttgc caagataaga gggacctcca atggcactgt     1800

aatcaacctt actgaattgg atggcacacc ctttcaccct tttgagggcc ctgcccccat     1860

tgggtttcca gacctcggtg gttgtgattg gcatatcaat atgacacagt ttggccattc     1920

tagccagacc cagtatgatg tagacaccac ccctgacact tttgtccccc atcttggttc     1980

aattcaggca aatggcattg gcagtggtaa ttatgttggt gttcttagct ggatttcccc     2040

cccatcacac ccgtctggct cccaagttga cctttggaag atccccaatt atgggtcaag     2100

tattacggag gcaacacatc tagccccttc tgtatacccc cctggtttcg gagaggtatt     2160

ggtctttttc atgtcaaaaa tgccaggtcc tggtgcttat aatttgccct gtctattacc     2220

acaagagtac atttcacatc ttgctagtga acaagcccct actgtaggtg aggctgccct     2280

gctccactat gttgaccctg ataccggtcg gaatcttggg gaattcaaag cataccctga     2340

tggtttcctc acttgtgtcc ccaatggggc tagctcgggt ccacaacagc tgccgatcaa     2400

tggggtcttt gtctttgttt catgggtgtc cagattttat caattaaagc ctgtgggaac     2460

tgccagctcg gcaagaggta ggcttggtct gcgccgataa aggcctattt tctttagttt     2520

gaatttactg ttattcggtg tgcatttcta tgtttggtga gcggttttct gtgctcagag     2580

tgtgtttatt ttatgtaatt taatttcttt gtgagctcct gtttagcagg tcgtcccttc     2640

agcaaggaca caaaaagatt ttaattttat taaaaaaaaa aaaaaaaaag accgggaatt     2700

cgatatcaag cttatcgacc tgcagatcgt tcaaacattt ggcaataaag tttcttaaga     2760

ttgaatcctg ttgccggtct tgcgatgatt atcatataat ttctgttgaa ttacgttaag     2820

catgtaataa ttaacatgta atgcatgacg ttatttatga gatgggtttt tatgattaga     2880

gtcccgcaat tatacattta atacgcgata gaaaacaaaa tatagcgcgc aaactaggat     2940

aaattatcgc gcgcggtgtc atctatgtta ctagat                               2976


<210>  76
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  IF-NoV(US68)VP1(ORF2)(hCod).c

<400>  76
tcgtgcttcg gcaccagtac aatgatgatg gctagtaaag atgcgacct                   49


<210>  77
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  IF-NoV(US68)VP1(ORF2)(hCod).r

<400>  77
actaaagaaa ataggccttt atctccgcag accgaggcgt ccgcgggcag aa               52


<210>  78
<211>  2976
<212>  DNA
<213>  Artificial

<220>
<223>  Expression cassette number 2724 from 2X35S promoter to NOS 
       terminator

<400>  78
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg atgatggcta gtaaagatgc gacctcctct gtggatggtg cgtcaggggc      960

aggacaactc gtacccgagg taaacgccag cgacccactt gccatggacc ccgttgccgg     1020

aagttccaca gcagtggcca cagccggtca agtgaatcca attgatccgt ggattatcaa     1080

caatttcgtc caggcacccc agggcgagtt cacaatttca ccaaacaata caccgggcga     1140

tgtgctattc gatctttcct tgggtcctca ccttaaccct tttctactcc atctctcaca     1200

gatgtacaat ggttgggtag gaaacatgag agtccggatc atgctggctg gcaatgcctt     1260

taccgctggc aagatcatcg tcagttgtat tcctcccgga tttggatctc ataatctgac     1320

cattgctcaa gcgactctct ttccccatgt catcgccgac gttaggaccc tggaccccat     1380

cgaggtgccc ctggaggacg tccggaatgt tttgttccac aacaacgaca gaaaccagca     1440

gacgatgaga cttgtctgta tgctctatac cccactgcgg actggaggcg ggactggaga     1500

ctccttcgtt gtggcaggaa gagtgatgac atgcccctcc cccgacttca actttctttt     1560

tctggtccca ccaaccgttg agcagaagac gcggcccttt acactgccca atctcccgct     1620

ttcaagtctg agtaattcac gggccccatt gccgatctcc tcaatgggaa tctcccccga     1680

caacgtccag tctgtccaat tccaaaatgg gagatgcaca ctggacggtc gcctggtggg     1740

aacaactccg gtgtccctct cacatgtcgc caaaatccgc ggcacatcaa atggtaccgt     1800

aatcaatctg acagaacttg atggcacgcc cttccatccc tttgaaggac cagcccctat     1860

tggatttcct gatctgggag gttgcgactg gcacataaac atgacacagt ttggccactc     1920

cagccagaca cagtatgatg tcgatacaac cccagatacc ttcgtgccac acctgggatc     1980

tattcaagct aacggtattg gatccggcaa ctacgtggga gtcttatctt ggatctcacc     2040

accatcccac ccctcaggat cccaggttga cttgtggaag ataccgaatt atggatcctc     2100

gatcactgaa gccacgcacc tcgcaccttc cgtctaccca ccaggttttg gagaagtctt     2160

ggtgtttttc atgagcaaaa tgcccggccc tggagcctac aatctccctt gcctactccc     2220

tcaagagtat attagtcacc tcgcatctga gcaggccccg accgttggcg aggcagccct     2280

gctgcattat gtggatccgg acaccggcag gaacctgggt gagttcaaag cttatcctga     2340

cggttttcta acatgtgtac caaatggcgc ttccagcggc cctcaacagc tcccaatcaa     2400

tggcgtgttc gtttttgtca gctgggtaag ccgcttctac cagctgaagc ccgtggggac     2460

agcttcttct gcccgcggac gcctcggtct gcggagataa aggcctattt tctttagttt     2520

gaatttactg ttattcggtg tgcatttcta tgtttggtga gcggttttct gtgctcagag     2580

tgtgtttatt ttatgtaatt taatttcttt gtgagctcct gtttagcagg tcgtcccttc     2640

agcaaggaca caaaaagatt ttaattttat taaaaaaaaa aaaaaaaaag accgggaatt     2700

cgatatcaag cttatcgacc tgcagatcgt tcaaacattt ggcaataaag tttcttaaga     2760

ttgaatcctg ttgccggtct tgcgatgatt atcatataat ttctgttgaa ttacgttaag     2820

catgtaataa ttaacatgta atgcatgacg ttatttatga gatgggtttt tatgattaga     2880

gtcccgcaat tatacattta atacgcgata gaaaacaaaa tatagcgcgc aaactaggat     2940

aaattatcgc gcgcggtgtc atctatgtta ctagat                               2976


<210>  79
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  IF-NoV(US68)VP2(ORF3)(hCod).c

<400>  79
tcgtgcttcg gcaccagtac aatggctcag gccattattg gcgccat                     47


<210>  80
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  IF-NoV(US68)VP2(ORF3)(hCod).r

<400>  80
actaaagaaa ataggccttc agcggcggtt gttagcgaac agaggaagtc                  50


<210>  81
<211>  2022
<212>  DNA
<213>  Artificial

<220>
<223>  Expression cassette number 2725 from 2X35S promoter to NOS 
       terminator

<400>  81
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg gctcaggcca ttattggcgc catcgctgca agtacagccg ggagtgcatt      960

gggggccgga atacaggtgg gcggggaagc tgcattgcag agccagcggt accagcaaaa     1020

cctgcagtta caggagaata gctttaaaca cgacagggag atgattggat atcaggtgga     1080

ggccagcaat cagctgctcg ccaaaaactt ggctactcga tactcattac tgcgcgccgg     1140

ggggttgact agcgccgacg ccgcacgatc tgtcgcaggc gcccccgtga ctcggatcgt     1200

agactggaac ggggtacgag tctcggctcc cgagtcgtct gcaaccaccc tgaggtcggg     1260

agggtttatg tccgtgccca tcccattcgc tagcaaacag aaacaggtcc agagctccgg     1320

aatctccaat cccaattact cccctagctc tatctctcgt accacttcct gggtcgagag     1380

tcagaacagc agtagatttg gcaacctgag cccctaccat gctgaagccc tgaacactgt     1440

gtggttgact ccacctggta gcacggcctc ctcaaccctg agttccgtgc ctcgcgggta     1500

cttcaatacc gacagacttc ctctgttcgc taacaaccgc cgctgaaggc ctattttctt     1560

tagtttgaat ttactgttat tcggtgtgca tttctatgtt tggtgagcgg ttttctgtgc     1620

tcagagtgtg tttattttat gtaatttaat ttctttgtga gctcctgttt agcaggtcgt     1680

cccttcagca aggacacaaa aagattttaa ttttattaaa aaaaaaaaaa aaaaagaccg     1740

ggaattcgat atcaagctta tcgacctgca gatcgttcaa acatttggca ataaagtttc     1800

ttaagattga atcctgttgc cggtcttgcg atgattatca tataatttct gttgaattac     1860

gttaagcatg taataattaa catgtaatgc atgacgttat ttatgagatg ggtttttatg     1920

attagagtcc cgcaattata catttaatac gcgatagaaa acaaaatata gcgcgcaaac     1980

taggataaat tatcgcgcgc ggtgtcatct atgttactag at                        2022


<210>  82
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GI2Leu03VP1.c

<400>  82
tcgtgcttcg gcaccagtac aatgatgatg gcttcaaagg atgctcccca aa               52


<210>  83
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GI2Leu03VP1.r

<400>  83
actaaagaaa ataggccttc agattcggcg gacccctagc ctgccgcgtg ccgtaga          57


<210>  84
<211>  3024
<212>  DNA
<213>  Artificial

<220>
<223>  Expression cassette number 3300 from 2X35S promoter to NOS 
       terminator

<400>  84
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg atgatggctt caaaggatgc tccccaaagc gcggacggag ctagcggcgc      960

cggacagttg gttccggaag tcaacactgc cgatccactg cccatggaac ccgtagctgg     1020

tccaacaacc gctgttgcca ccgccggcca ggttaacatg atcgatccat ggattgttaa     1080

taactttgta cagagccccc agggggagtt cacaatttct ccgaacaata cccctgggga     1140

cattctgttc gatctgcaac tgggcccaca cttgaatcct ttcctgagcc atctttcaca     1200

gatgtacaac ggatgggttg ggaacatgcg tgttcggatc ctccttgctg gcaacgcctt     1260

cagtgctggc aagattatcg tgtgctgcgt accaccaggg tttacctcga gttcattaac     1320

cattgctcag gccacccttt tccctcacgt gatcgcagac gtgcgtacct tagaaccaat     1380

cgaaatgccc ctggaagatg tacggaacgt gctgtaccat actaatgata accagccaac     1440

gatgagatta gtgtgcatgc tgtacacccc cctgagaact ggaggaggtt ctggaaattc     1500

cgacagtttt gtggtggctg gcagggtcct gaccgctccc agtagcgact tcagcttttt     1560

gttcctcgtt cctcctacaa tcgaacaaaa aacaagagca ttcacagtgc ccaacattcc     1620

actgcagact ttaagcaatt ccaggtttcc cagcttgatc cagggtatga tcctttctcc     1680

cgacgcctcc caagttgtgc agttccagaa tgggagatgt cttatcgacg gtcagcttct     1740

gggaacaacc cctgccacct ccgggcaact cttccgggtg agaggcaaaa tcaatcaggg     1800

cgccagaaca ctgaatctga cagaagtgga cgggaaaccc tttatggcgt tcgatagccc     1860

cgcgcccgtt ggattccctg acttcggcaa gtgtgattgg cacatgcgca tcagtaagac     1920

tcccaacaac acttcatctg gagaccccat gaggagcgtg gatgtccaga ccgacgtgca     1980

gggcttcgtg ccgcacttgg gatctatcca gttcgatgag gtgttcaatc accctactgg     2040

cgactacata ggcacaattg agtggataag tcaaccatct acacctccag ggaccgacat     2100

aaacctgtgg gaaattcctg attacgggtc atccctgagt caagctgcca atcttgcacc     2160

ccctgtcttt ccccccggct ttggtgaggc tcttgtttac ttcgtctctg catttcctgg     2220

tcctaacaac cgctccgccc ctaacgatgt tccgtgtttg ttaccccagg aatatgtgac     2280

tcatttcgtt tccgaacagg cacccaccat gggggacgct gccctgctac actatgtgga     2340

ccccgacacc aatagaaacc tcggcgagtt caaactctac cccgggggat acctgacctg     2400

tgttccaaat ggagtgggag caggcccaca acagctgccc ctgaatgggg tcttcctgtt     2460

cgtttcttgg gtgtcacgct tttaccagct gaagcccgtt ggcacagctt ctacggcacg     2520

cggcaggcta ggggtccgcc gaatctgaag gcctattttc tttagtttga atttactgtt     2580

attcggtgtg catttctatg tttggtgagc ggttttctgt gctcagagtg tgtttatttt     2640

atgtaattta atttctttgt gagctcctgt ttagcaggtc gtcccttcag caaggacaca     2700

aaaagatttt aattttatta aaaaaaaaaa aaaaaaagac cgggaattcg atatcaagct     2760

tatcgacctg cagatcgttc aaacatttgg caataaagtt tcttaagatt gaatcctgtt     2820

gccggtcttg cgatgattat catataattt ctgttgaatt acgttaagca tgtaataatt     2880

aacatgtaat gcatgacgtt atttatgaga tgggttttta tgattagagt cccgcaatta     2940

tacatttaat acgcgataga aaacaaaata tagcgcgcaa actaggataa attatcgcgc     3000

gcggtgtcat ctatgttact agat                                            3024


<210>  85
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  GI2Leu+GI1VP1.r

<400>  85
atgctcttgt tttttgctca acggttggtg ggaccagaaa aagaaagttg aagtcg           56


<210>  86
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  GI1VP1+GI2Leu.c

<400>  86
tcccaccaac cgttgagcaa aaaacaagag cattcacagt gcccaacat                   49


<210>  87
<211>  3021
<212>  DNA
<213>  Artificial

<220>
<223>  Expression cassette number 3360 from 2X35S promoter to NOS 
       terminator

<400>  87
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaatg atgatggcta gtaaagatgc gacctcctct gtggatggtg cgtcaggggc      960

aggacaactc gtacccgagg taaacgccag cgacccactt gccatggacc ccgttgccgg     1020

aagttccaca gcagtggcca cagccggtca agtgaatcca attgatccgt ggattatcaa     1080

caatttcgtc caggcacccc agggcgagtt cacaatttca ccaaacaata caccgggcga     1140

tgtgctattc gatctttcct tgggtcctca ccttaaccct tttctactcc atctctcaca     1200

gatgtacaat ggttgggtag gaaacatgag agtccggatc atgctggctg gcaatgcctt     1260

taccgctggc aagatcatcg tcagttgtat tcctcccgga tttggatctc ataatctgac     1320

cattgctcaa gcgactctct ttccccatgt catcgccgac gttaggaccc tggaccccat     1380

cgaggtgccc ctggaggacg tccggaatgt tttgttccac aacaacgaca gaaaccagca     1440

gacgatgaga cttgtctgta tgctctatac cccactgcgg actggaggcg ggactggaga     1500

ctccttcgtt gtggcaggaa gagtgatgac atgcccctcc cccgacttca actttctttt     1560

tctggtccca ccaaccgttg agcaaaaaac aagagcattc acagtgccca acattccact     1620

gcagacttta agcaattcca ggtttcccag cttgatccag ggtatgatcc tttctcccga     1680

cgcctcccaa gttgtgcagt tccagaatgg gagatgtctt atcgacggtc agcttctggg     1740

aacaacccct gccacctccg ggcaactctt ccgggtgaga ggcaaaatca atcagggcgc     1800

cagaacactg aatctgacag aagtggacgg gaaacccttt atggcgttcg atagccccgc     1860

gcccgttgga ttccctgact tcggcaagtg tgattggcac atgcgcatca gtaagactcc     1920

caacaacact tcatctggag accccatgag gagcgtggat gtccagaccg acgtgcaggg     1980

cttcgtgccg cacttgggat ctatccagtt cgatgaggtg ttcaatcacc ctactggcga     2040

ctacataggc acaattgagt ggataagtca accatctaca cctccaggga ccgacataaa     2100

cctgtgggaa attcctgatt acgggtcatc cctgagtcaa gctgccaatc ttgcaccccc     2160

tgtctttccc cccggctttg gtgaggctct tgtttacttc gtctctgcat ttcctggtcc     2220

taacaaccgc tccgccccta acgatgttcc gtgtttgtta ccccaggaat atgtgactca     2280

tttcgtttcc gaacaggcac ccaccatggg ggacgctgcc ctgctacact atgtggaccc     2340

cgacaccaat agaaacctcg gcgagttcaa actctacccc gggggatacc tgacctgtgt     2400

tccaaatgga gtgggagcag gcccacaaca gctgcccctg aatggggtct tcctgttcgt     2460

ttcttgggtg tcacgctttt accagctgaa gcccgttggc acagcttcta cggcacgcgg     2520

caggctaggg gtccgccgaa tctgaaggcc tattttcttt agtttgaatt tactgttatt     2580

cggtgtgcat ttctatgttt ggtgagcggt tttctgtgct cagagtgtgt ttattttatg     2640

taatttaatt tctttgtgag ctcctgttta gcaggtcgtc ccttcagcaa ggacacaaaa     2700

agattttaat tttattaaaa aaaaaaaaaa aaaagaccgg gaattcgata tcaagcttat     2760

cgacctgcag atcgttcaaa catttggcaa taaagtttct taagattgaa tcctgttgcc     2820

ggtcttgcga tgattatcat ataatttctg ttgaattacg ttaagcatgt aataattaac     2880

atgtaatgca tgacgttatt tatgagatgg gtttttatga ttagagtccc gcaattatac     2940

atttaatacg cgatagaaaa caaaatatag cgcgcaaact aggataaatt atcgcgcgcg     3000

gtgtcatcta tgttactaga t                                               3021


<210>  88
<211>  15
<212>  PRT
<213>  Norovirus GI.1/Norwalk/1968/US

<400>  88

Leu Val Pro Pro Thr Val Glu Gln Lys Thr Arg Pro Phe Thr Leu 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Norovirus GI.2/Leuven/2003/Bel

<400>  89

Leu Val Pro Pro Thr Ile Glu Gln Lys Thr Arg Ala Phe Thr Val 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Norovirus GI.3/S29/2008/Lilla Edet/Sweden

<400>  90

Leu Val Pro Pro Asn Val Glu Gln Lys Thr Lys Pro Phe Ser Val 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Norovirus GII.4/Sydney/NSW0514/2012/AU

<400>  91

Leu Val Pro Pro Thr Val Glu Ser Arg Thr Lys Pro Phe Ser Val 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Norovirus GII.6/Ohio/490/12

<400>  92

Leu Val Pro Pro Thr Val Glu Ser Lys Thr Lys Pro Phe Ser Leu 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Norovirus GII.13/VA173/2010/USA

<400>  93

Leu Val Pro Pro Ser Val Glu Ser Lys Thr Lys Pro Phe Thr Leu 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Norovirus GII.17/Kawasaki323/2014/JP

<400>  94

Leu Val Pro Pro Ser Val Glu Ser Lys Thr Lys Pro Phe Ser Leu 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Consensus


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be Ser, Thr or Asn

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa can be Val or Ile

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa can be Ser or Gln

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa can be Pro or Ala

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa can be Ser or Thr

<400>  95

Leu Val Pro Pro Xaa Xaa Glu Xaa Lys Thr Lys Xaa Phe Xaa Ile 
1               5                   10                  15  


<210>  96
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  GI3Lil+GI1VP1.r

<400>  96
gaatggcttt gttttctgct caacggttgg tgggaccaga aaaagaaagt tgaagt           56


<210>  97
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  GI1VP1+GI3Lil.c

<400>  97
tcccaccaac cgttgagcag aaaacaaagc cattcagcgt gccaaacc                    48


<210>  98
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GI3Lil08VP1.r

<400>  98
actaaagaaa ataggcctct agctccgtct gatcccgagc ctccgaact                   49


<210>  99
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  GII4Syd+GI1VP1.r

<400>  99
aagggcttgg ttcggctctc aacggttggt gggaccagaa aaagaaagt                   49


<210>  100
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  GI1VP1+GII4Syd.c

<400>  100
tcccaccaac cgttgagagc cgaaccaagc cctttagtgt ccccgtact                   49


<210>  101
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GII4Syd12VP1.r

<400>  101
actaaagaaa ataggccttc agacagccct gcgtctgcca gtcccatt                    48


<210>  102
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  GII6Ohi+GI1VP1.r

<400>  102
tcccaccaac cgttgagagc aagacaaaac ccttcagcct cccaatctta                  50


<210>  103
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  GI1VP1+GII6Ohi.c

<400>  103
tcccaccaac cgttgagagc aagacaaaac ccttcagcct cccaatctta                  50


<210>  104
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GII6Ohi12VP1.r

<400>  104
actaaagaaa ataggccttc actgatcccg gcgtcgcccc tggcctgtcc ccat             54


<210>  105
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  GII13Va+GI1VP1.r

<400>  105
aagggtttag tcttgctctc aacggttggt gggaccagaa aaagaaagt                   49


<210>  106
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  GI1VP1+GII13Va.c

<400>  106
tcccaccaac cgttgagagc aagactaaac cctttactct tcccattctg                  50


<210>  107
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GII13VA10VP1.r

<400>  107
actaaagaaa ataggccttc attgcacccg acggcgacca ttcccggtac cca              53


<210>  108
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  GII17Kaw+GI1VP1.r

<400>  108
aacggtttgg tcttagactc aacggttggt gggaccagaa aaagaaagtt gaagt            55


<210>  109
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  GI1VP1+GII17Kaw.c

<400>  109
tcccaccaac cgttgagtct aagaccaaac cgttttcact gccaatct                    48


<210>  110
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GII17Kaw14VP1.r

<400>  110
actaaagaaa ataggcctct actgagcccg gcgtctgccg ttaccggtgc ccattg           56


<210>  111
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GI3Lil08VP1.c

<400>  111
tcgtgcttcg gcaccagtac aatgatgatg gcttccaagg atgctccca                   49


<210>  112
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GII4Syd12VP1.c

<400>  112
tcgtgcttcg gcaccagtac aatgaaaatg gcctcgagtg acgctaacc                   49


<210>  113
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GII6Ohi12VP1.c

<400>  113
tcgtgcttcg gcaccagtac aatgaagatg gcaagcaacg acgcagctc                   49


<210>  114
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GII13VA10VP1.c

<400>  114
tcgtgcttcg gcaccagtac aatgaaaatg gcttctaatg atgccgcgcc cagcaatga        59


<210>  115
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GII17Kaw14VP1.c

<400>  115
tcgtgcttcg gcaccagtac aatgaaaatg gcatctaacg acgcagcccc ctc              53


<210>  116
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  IF-NoV(US68)VP2(ORF3).c

<400>  116
tcgtgcttcg gcaccagtac aatggcccaa gccataattg gtgcaatt                    48


<210>  117
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GII4Syd12VP2.c

<400>  117
tcgtgcttcg gcaccagtac aatggctggg gccttttttg caggtttggc tagt             54


<210>  118
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  IF-NoV(US68)VP1/VP2(ORF3)NoV3'UTR.r

<400>  118
actaaagaaa ataggcctaa catcaaatta aacctaatta aacctaat                    48


<210>  119
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  IF-GII4Syd12VP2.r

<400>  119
actaaagaaa ataggccttc atgctcgtga ctcacccctt ttgcgtatat gagc             54


<210>  120
<211>  804
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acid sequence of human codon-optimized VP2 GII.4/ 
       Sydney/NSW0514/2012/AU

<400>  120
atggctgggg ccttttttgc aggtttggct agtgacgtcc tcgggtcggg cctcggaagt       60

ctgatcaatg caggagctgg agcgattaat caaaaagtcg agttcgagaa taaccggaaa      120

cttcaacagg caagtttcca attctcaagc aatttgcagc aggcctcatt ccaacacgac      180

aaggaaatgc tccaggccca gattgaggcc accaagaaac tgcaacaaga gatgatgaag      240

gtcaaacagg ccatgctgct ggagggcggc tttttcgaga ccgatgctgc gcgcggagcc      300

atcaacgccc caatgacaaa ggcactcgac tggagtggca cacggtattg ggcacccgat      360

gccagaacga ctacctataa tgccggaagg ttctccacac ctcaaccttc tggtgccctc      420

ccagggcgcg caaatctgag ggacgctgtg cccgctaggg gctcctcatc aaagtcttcc      480

aatagctcca ctgcaacctc ggtttactca aaccagacca cttcaacaag attaggatca      540

accgccgtgt cgggaacatc tgtctcctct tttccttcta cagcacgaac caggtcttgg      600

gtcgaggacc agagcagaaa cctgtctccg tccatgcgcg gtgctcacaa catttccttc      660

gtgacccctc cttcttcccg atcctccagc caagggacag tgtccacagt gcccaaagaa      720

gtgctcgact cttggacagg tgcgttcaat accagacgcc agcctctctt tgctcatata      780

cgcaaaaggg gtgagtcacg agca                                             804


<210>  121
<211>  268
<212>  PRT
<213>  Norovirus GII.4/ Sydney/NSW0514/2012/AU

<400>  121

Met Ala Gly Ala Phe Phe Ala Gly Leu Ala Ser Asp Val Leu Gly Ser 
1               5                   10                  15      


Gly Leu Gly Ser Leu Ile Asn Ala Gly Ala Gly Ala Ile Asn Gln Lys 
            20                  25                  30          


Val Glu Phe Glu Asn Asn Arg Lys Leu Gln Gln Ala Ser Phe Gln Phe 
        35                  40                  45              


Ser Ser Asn Leu Gln Gln Ala Ser Phe Gln His Asp Lys Glu Met Leu 
    50                  55                  60                  


Gln Ala Gln Ile Glu Ala Thr Lys Lys Leu Gln Gln Glu Met Met Lys 
65                  70                  75                  80  


Val Lys Gln Ala Met Leu Leu Glu Gly Gly Phe Phe Glu Thr Asp Ala 
                85                  90                  95      


Ala Arg Gly Ala Ile Asn Ala Pro Met Thr Lys Ala Leu Asp Trp Ser 
            100                 105                 110         


Gly Thr Arg Tyr Trp Ala Pro Asp Ala Arg Thr Thr Thr Tyr Asn Ala 
        115                 120                 125             


Gly Arg Phe Ser Thr Pro Gln Pro Ser Gly Ala Leu Pro Gly Arg Ala 
    130                 135                 140                 


Asn Leu Arg Asp Ala Val Pro Ala Arg Gly Ser Ser Ser Lys Ser Ser 
145                 150                 155                 160 


Asn Ser Ser Thr Ala Thr Ser Val Tyr Ser Asn Gln Thr Thr Ser Thr 
                165                 170                 175     


Arg Leu Gly Ser Thr Ala Val Ser Gly Thr Ser Val Ser Ser Phe Pro 
            180                 185                 190         


Ser Thr Ala Arg Thr Arg Ser Trp Val Glu Asp Gln Ser Arg Asn Leu 
        195                 200                 205             


Ser Pro Ser Met Arg Gly Ala His Asn Ile Ser Phe Val Thr Pro Pro 
    210                 215                 220                 


Ser Ser Arg Ser Ser Ser Gln Gly Thr Val Ser Thr Val Pro Lys Glu 
225                 230                 235                 240 


Val Leu Asp Ser Trp Thr Gly Ala Phe Asn Thr Arg Arg Gln Pro Leu 
                245                 250                 255     


Phe Ala His Ile Arg Lys Arg Gly Glu Ser Arg Ala 
            260                 265             


<210>  122
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  IF-NoV(US68)VP2(ORF3).r

<400>  122
actaaagaaa ataggcctaa catcaaatta aacctaatta aacctaat                    48


