                         SEQUENCE LISTING

<110>  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
 
<120>  ADENO-ASSOCIATED VIRUS VECTOR DELIVERY OF MUSCLE SPECIFIC 
       MICRO-DYSTROPHIN TO TREAT MUSCULAR DYSTROPHY

<130>  28335/51475A PCT

<150>  US 62/473,148
<151>  2017-03-17

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  3579
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctgtggt gggaggaggt ggaggattgt tatgaaaggg aggacgtgca gaagaagact       60

tttaccaagt gggtgaacgc tcagttcagc aaatttggga agcagcacat cgagaatctg      120

ttttccgacc tgcaggatgg gagacggctg ctggatctgc tggaaggact gactggccag      180

aagctgccca aagagaaggg gagcactagg gtgcacgccc tgaacaacgt gaacaaagct      240

ctgagagtgc tgcagaacaa caacgtggat ctggtgaata ttggcagtac tgatatcgtg      300

gacgggaacc acaaactgac actgggcctg atctggaaca ttattctgca ctggcaggtg      360

aaaaatgtga tgaagaacat catggccggg ctgcagcaga ccaattccga gaagatcctg      420

ctgtcttggg tgcggcagag cacccgcaac tatccccagg tgaacgtgat taacttcact      480

acatcctgga gcgacgggct ggccctgaat gctctgattc acagccacag gcctgatctg      540

ttcgactgga atagcgtggt gtgccagcag tctgccacac agcgcctgga acatgccttc      600

aatatcgctc ggtaccagct ggggatcgaa aaactgctgg acccagagga tgtggacact      660

acatacccag ataaaaagtc tattctgatg tacattacta gcctgttcca ggtgctgcca      720

cagcaggtgt ctattgaagc cattcaggag gtggaaatgc tgccccgccc ccccaaagtg      780

actaaagagg agcattttca gctgcatcat cagatgcatt acagccagca gattaccgtg      840

agcctggctc agggatatga gcgcaccagt agtccaaaac cacggttcaa gtcctacgct      900

tatacccagg ctgcctacgt gacaactagc gaccctacta gatccccctt tccatcccag      960

cacctggagg ccccagagga caagagcttt gggtccagcc tgatggaaag cgaggtgaat     1020

ctggatcggt accagacagc cctggaggag gtgctgagct ggctgctgag tgctgaagac     1080

acactgcagg cccagggcga aatttccaat gacgtggaag tggtgaagga tcagttccac     1140

acacacgagg gctatatgat ggacctgaca gctcaccagg ggcgcgtggg caatatcctg     1200

cagctgggct ctaaactgat cggcaccggg aaactgagtg aggacgagga aacagaagtg     1260

caggagcaga tgaacctgct gaacagccgc tgggagtgtc tgagagtggc tagtatggag     1320

aagcagtcca acctgcaccg ggtgctgatg gacctgcaga accagaaact gaaagagctg     1380

aacgactggc tgacaaagac tgaggaacgc acaaggaaga tggaggagga gccactggga     1440

cccgacctgg aggatctgaa gagacaggtg cagcagcata aggtgctgca ggaggatctg     1500

gaacaggagc aggtgcgggt gaactccctg acacatatgg tggtggtggt ggacgaatct     1560

agtggagatc acgccaccgc cgccctggag gaacagctga aggtgctggg ggaccggtgg     1620

gccaacattt gccggtggac cgaggacagg tgggtgctgc tgcaggacat cctgctgaaa     1680

tggcagaggc tgaccgagga gcagtgtctg tttagtgctt ggctgagcga gaaagaggac     1740

gccgtgaaca agatccacac aaccggcttt aaggatcaga acgaaatgct gtctagcctg     1800

cagaaactgg ctgtgctgaa ggccgatctg gagaaaaaga agcagagcat gggcaaactg     1860

tatagcctga aacaggacct gctgagcacc ctgaagaaca agagcgtgac ccagaagaca     1920

gaagcctggc tggataactt tgcccgctgc tgggacaacc tggtgcagaa actggagaaa     1980

agtacagctc agatctctca ggctgtgacc acaacccagc ctagcctgac ccagacaacc     2040

gtgatggaaa ccgtgaccac cgtgacaacc cgcgaacaga tcctggtgaa acatgcccag     2100

gaagagctgc cacctccacc tccccagaag aagagaaccc tggagcggct gcaggagctg     2160

caggaagcca ctgacgaact ggacctgaag ctgaggcagg ccgaagtgat taaggggtct     2220

tggcagcctg tgggcgatct gctgattgat tccctgcagg accacctgga aaaggtgaag     2280

gctctgagag gcgaaattgc tccactgaag gagaacgtga gtcatgtgaa cgatctggct     2340

agacagctga caacactggg catccagctg agcccataca atctgagcac actggaggac     2400

ctgaatacca ggtggaagct gctgcaggtg gctgtggaag accgggtgcg gcagctgcat     2460

gaggcccatc gcgacttcgg accagccagc cagcactttc tgagcacatc cgtgcagggg     2520

ccctgggaga gggccatttc tcccaacaag gtgccctact atattaatca cgagacccag     2580

accacttgtt gggaccatcc caagatgaca gaactgtacc agtccctggc cgatctgaac     2640

aacgtgaggt ttagcgctta cagaaccgct atgaagctga gacggctgca gaaggccctg     2700

tgcctggatc tgctgtccct gtccgccgcc tgcgatgccc tggatcagca taatctgaag     2760

cagaacgatc agccaatgga tatcctgcag atcatcaact gcctgaccac tatctacgac     2820

aggctggagc aggagcacaa caacctggtg aacgtgcctc tgtgcgtgga tatgtgcctg     2880

aactggctgc tgaacgtgta tgacactggg cgcaccggcc ggatcagagt gctgagtttt     2940

aaaactggga ttatctccct gtgtaaggcc cacctggagg acaagtacag gtacctgttc     3000

aagcaggtgg ctagtagcac tggattttgt gaccagcgcc gcctgggact gctgctgcat     3060

gatagtatcc agattcctag acagctggga gaggtggcta gtttcggagg atctaacatc     3120

gaacccagcg tgcgcagctg tttccagttt gccaataaca aacctgaaat cgaggctgct     3180

ctgttcctgg attggatgcg cctggaacca cagagcatgg tgtggctgcc tgtgctgcac     3240

agagtggctg ccgccgaaac tgccaagcac caggctaaat gcaacatctg caaggaatgt     3300

cccattatcg gctttcgcta caggagtctg aaacatttta actacgatat ttgccagagc     3360

tgcttctttt ccggaagagt ggccaaagga cacaagatgc actaccctat ggtggaatat     3420

tgcaccccaa ctacatctgg cgaagatgtg cgcgattttg ccaaggtgct gaagaataag     3480

tttcggacta agaggtactt cgccaagcac ccccgcatgg ggtatctgcc agtgcagaca     3540

gtgctggaag gagacaatat ggagaccgat acaatgtga                            3579


<210>  2
<211>  810
<212>  DNA
<213>  Adeno-associated virus

<400>  2
gtttaaacaa gcttgcatgt ctaagctaga cccttcagat taaaaataac tgaggtaagg       60

gcctgggtag gggaggtggt gtgagacgct cctgtctctc ctctatctgc ccatcggccc      120

tttggggagg aggaatgtgc ccaaggacta aaaaaaggcc atggagccag aggggcgagg      180

gcaacagacc tttcatgggc aaaccttggg gccctgctgt ctagcatgcc ccactacggg      240

tctaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct ggttataatt      300

aacccagaca tgtggctgcc cccccccccc caacacctgc tgcctctaaa aataaccctg      360

tccctggtgg atcccctgca tgcgaagatc ttcgaacaag gctgtggggg actgagggca      420

ggctgtaaca ggcttggggg ccagggctta tacgtgcctg ggactcccaa agtattactg      480

ttccatgttc ccggcgaagg gccagctgtc ccccgccagc tagactcagc acttagttta      540

ggaaccagtg agcaagtcag cccttggggc agcccataca aggccatggg gctgggcaag      600

ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa cgagctgaaa gctcatctgc      660

tctcaggggc ccctccctgg ggacagcccc tcctggctag tcacaccctg taggctcctc      720

tatataaccc aggggcacag gggctgccct cattctacca ccacctccac agcacagaca      780

gacactcagg agccagccag cggcgcgccc                                       810


<210>  3
<211>  8611
<212>  DNA
<213>  Adeno-associated virus

<400>  3
gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcgcg       60

ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc      120

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc actaggggtt      180

ccttgtagtt aatgattaac ccgccatgct aattatctac gtagccatgt ctagagttta      240

aacaagcttg catgtctaag ctagaccctt cagattaaaa ataactgagg taagggcctg      300

ggtaggggag gtggtgtgag acgctcctgt ctctcctcta tctgcccatc ggccctttgg      360

ggaggaggaa tgtgcccaag gactaaaaaa aggccatgga gccagagggg cgagggcaac      420

agacctttca tgggcaaacc ttggggccct gctgtctagc atgccccact acgggtctag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc ccccccaaca cctgctgcct ctaaaaataa ccctgtccct      600

ggtggatccc ctgcatgcga agatcttcga acaaggctgt gggggactga gggcaggctg      660

taacaggctt gggggccagg gcttatacgt gcctgggact cccaaagtat tactgttcca      720

tgttcccggc gaagggccag ctgtcccccg ccagctagac tcagcactta gtttaggaac      780

cagtgagcaa gtcagccctt ggggcagccc atacaaggcc atggggctgg gcaagctgca      840

cgcctgggtc cggggtgggc acggtgcccg ggcaacgagc tgaaagctca tctgctctca      900

ggggcccctc cctggggaca gcccctcctg gctagtcaca ccctgtaggc tcctctatat      960

aacccagggg cacaggggct gccctcattc taccaccacc tccacagcac agacagacac     1020

tcaggagcca gccagcggcg cgcccaggta agtttagtct ttttgtcttt tatttcaggt     1080

cccggatccg gtggtggtgc aaatcaaaga actgctcctc agtggatgtt gcctttactt     1140

ctaggcctgt acggaagtgt tacttctgct ctaaaagctg cggaattgta cccgcggccg     1200

ccaccatgct gtggtgggag gaggtggagg attgttatga aagggaggac gtgcagaaga     1260

agacttttac caagtgggtg aacgctcagt tcagcaaatt tgggaagcag cacatcgaga     1320

atctgttttc cgacctgcag gatgggagac ggctgctgga tctgctggaa ggactgactg     1380

gccagaagct gcccaaagag aaggggagca ctagggtgca cgccctgaac aacgtgaaca     1440

aagctctgag agtgctgcag aacaacaacg tggatctggt gaatattggc agtactgata     1500

tcgtggacgg gaaccacaaa ctgacactgg gcctgatctg gaacattatt ctgcactggc     1560

aggtgaaaaa tgtgatgaag aacatcatgg ccgggctgca gcagaccaat tccgagaaga     1620

tcctgctgtc ttgggtgcgg cagagcaccc gcaactatcc ccaggtgaac gtgattaact     1680

tcactacatc ctggagcgac gggctggccc tgaatgctct gattcacagc cacaggcctg     1740

atctgttcga ctggaatagc gtggtgtgcc agcagtctgc cacacagcgc ctggaacatg     1800

ccttcaatat cgctcggtac cagctgggga tcgaaaaact gctggaccca gaggatgtgg     1860

acactacata cccagataaa aagtctattc tgatgtacat tactagcctg ttccaggtgc     1920

tgccacagca ggtgtctatt gaagccattc aggaggtgga aatgctgccc cgccccccca     1980

aagtgactaa agaggagcat tttcagctgc atcatcagat gcattacagc cagcagatta     2040

ccgtgagcct ggctcaggga tatgagcgca ccagtagtcc aaaaccacgg ttcaagtcct     2100

acgcttatac ccaggctgcc tacgtgacaa ctagcgaccc tactagatcc ccctttccat     2160

cccagcacct ggaggcccca gaggacaaga gctttgggtc cagcctgatg gaaagcgagg     2220

tgaatctgga tcggtaccag acagccctgg aggaggtgct gagctggctg ctgagtgctg     2280

aagacacact gcaggcccag ggcgaaattt ccaatgacgt ggaagtggtg aaggatcagt     2340

tccacacaca cgagggctat atgatggacc tgacagctca ccaggggcgc gtgggcaata     2400

tcctgcagct gggctctaaa ctgatcggca ccgggaaact gagtgaggac gaggaaacag     2460

aagtgcagga gcagatgaac ctgctgaaca gccgctggga gtgtctgaga gtggctagta     2520

tggagaagca gtccaacctg caccgggtgc tgatggacct gcagaaccag aaactgaaag     2580

agctgaacga ctggctgaca aagactgagg aacgcacaag gaagatggag gaggagccac     2640

tgggacccga cctggaggat ctgaagagac aggtgcagca gcataaggtg ctgcaggagg     2700

atctggaaca ggagcaggtg cgggtgaact ccctgacaca tatggtggtg gtggtggacg     2760

aatctagtgg agatcacgcc accgccgccc tggaggaaca gctgaaggtg ctgggggacc     2820

ggtgggccaa catttgccgg tggaccgagg acaggtgggt gctgctgcag gacatcctgc     2880

tgaaatggca gaggctgacc gaggagcagt gtctgtttag tgcttggctg agcgagaaag     2940

aggacgccgt gaacaagatc cacacaaccg gctttaagga tcagaacgaa atgctgtcta     3000

gcctgcagaa actggctgtg ctgaaggccg atctggagaa aaagaagcag agcatgggca     3060

aactgtatag cctgaaacag gacctgctga gcaccctgaa gaacaagagc gtgacccaga     3120

agacagaagc ctggctggat aactttgccc gctgctggga caacctggtg cagaaactgg     3180

agaaaagtac agctcagatc tctcaggctg tgaccacaac ccagcctagc ctgacccaga     3240

caaccgtgat ggaaaccgtg accaccgtga caacccgcga acagatcctg gtgaaacatg     3300

cccaggaaga gctgccacct ccacctcccc agaagaagag aaccctggag cggctgcagg     3360

agctgcagga agccactgac gaactggacc tgaagctgag gcaggccgaa gtgattaagg     3420

ggtcttggca gcctgtgggc gatctgctga ttgattccct gcaggaccac ctggaaaagg     3480

tgaaggctct gagaggcgaa attgctccac tgaaggagaa cgtgagtcat gtgaacgatc     3540

tggctagaca gctgacaaca ctgggcatcc agctgagccc atacaatctg agcacactgg     3600

aggacctgaa taccaggtgg aagctgctgc aggtggctgt ggaagaccgg gtgcggcagc     3660

tgcatgaggc ccatcgcgac ttcggaccag ccagccagca ctttctgagc acatccgtgc     3720

aggggccctg ggagagggcc atttctccca acaaggtgcc ctactatatt aatcacgaga     3780

cccagaccac ttgttgggac catcccaaga tgacagaact gtaccagtcc ctggccgatc     3840

tgaacaacgt gaggtttagc gcttacagaa ccgctatgaa gctgagacgg ctgcagaagg     3900

ccctgtgcct ggatctgctg tccctgtccg ccgcctgcga tgccctggat cagcataatc     3960

tgaagcagaa cgatcagcca atggatatcc tgcagatcat caactgcctg accactatct     4020

acgacaggct ggagcaggag cacaacaacc tggtgaacgt gcctctgtgc gtggatatgt     4080

gcctgaactg gctgctgaac gtgtatgaca ctgggcgcac cggccggatc agagtgctga     4140

gttttaaaac tgggattatc tccctgtgta aggcccacct ggaggacaag tacaggtacc     4200

tgttcaagca ggtggctagt agcactggat tttgtgacca gcgccgcctg ggactgctgc     4260

tgcatgatag tatccagatt cctagacagc tgggagaggt ggctagtttc ggaggatcta     4320

acatcgaacc cagcgtgcgc agctgtttcc agtttgccaa taacaaacct gaaatcgagg     4380

ctgctctgtt cctggattgg atgcgcctgg aaccacagag catggtgtgg ctgcctgtgc     4440

tgcacagagt ggctgccgcc gaaactgcca agcaccaggc taaatgcaac atctgcaagg     4500

aatgtcccat tatcggcttt cgctacagga gtctgaaaca ttttaactac gatatttgcc     4560

agagctgctt cttttccgga agagtggcca aaggacacaa gatgcactac cctatggtgg     4620

aatattgcac cccaactaca tctggcgaag atgtgcgcga ttttgccaag gtgctgaaga     4680

ataagtttcg gactaagagg tacttcgcca agcacccccg catggggtat ctgccagtgc     4740

agacagtgct ggaaggagac aatatggaga ccgatacaat gtgagcggcc gcaataaaag     4800

atctttattt tcattagatc tgtgtgttgg ttttttgtgt gtctagagca tggctacgta     4860

gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc     4920

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4980

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gccagctggc gtaatagcga     5040

agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggaagtt     5100

ccagacgatt gagcgtcaaa atgtaggtat ttccatgagc gtttttcctg ttgcaatggc     5160

tggcggtaat attgttctgg atattaccag caaggccgat agtttgagtt cttctactca     5220

ggcaagtgat gttattacta atcaaagaag tattgcgaca acggttaatt tgcgtgatgg     5280

acagactctt ttactcggtg gcctcactga ttataaaaac acttctcagg attctggcgt     5340

accgttcctg tctaaaatcc ctttaatcgg cctcctgttt agctcccgct ctgattctaa     5400

cgaggaaagc acgttatacg tgctcgtcaa agcaaccata gtacgcgccc tgtagcggcg     5460

cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc     5520

tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc     5580

gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgattta cggcacctcg     5640

accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg     5700

tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg     5760

gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt     5820

cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa     5880

tattaacgtt tacaatttaa atatttgctt atacaatctt cctgtttttg gggcttttct     5940

gattatcaac cggggtacat atgattgaca tgctagtttt acgattaccg ttcatcgatt     6000

ctcttgtttg ctccagactc tcaggcaatg acctgatagc ctttgtagag acctctcaaa     6060

aatagctacc ctctccggca tgaatttatc agctagaacg gttgaatatc atattgatgg     6120

tgatttgact gtctccggcc tttctcaccc gtttgaatct ttacctacac attactcagg     6180

cattgcattt aaaatatatg agggttctaa aaatttttat ccttgcgttg aaataaaggc     6240

ttctcccgca aaagtattac agggtcataa tgtttttggt acaaccgatt tagctttatg     6300

ctctgaggct ttattgctta attttgctaa ttctttgcct tgcctgtatg atttattgga     6360

tgttggaagt tcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc     6420

atatggtgca ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac     6480

ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga     6540

caagctgtga ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa     6600

cgcgcgagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata     6660

atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     6720

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     6780

cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt     6840

cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta     6900

aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc     6960

ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa     7020

gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc     7080

cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt     7140

acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact     7200

gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac     7260

aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata     7320

ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta     7380

ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg     7440

gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat     7500

aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt     7560

aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga     7620

aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa     7680

gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag     7740

gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac     7800

tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc     7860

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat     7920

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat     7980

actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcgt     8040

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt     8100

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg     8160

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta     8220

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg     8280

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg     8340

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc     8400

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg     8460

gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat     8520

aaccgtatta ccgggtttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc     8580

agcgagtcag tgagcgacca agcggaagag c                                    8611


<210>  4
<211>  564
<212>  DNA
<213>  Adeno-associated virus

<400>  4
cagccactat gggtctaggc tgcccatgta aggaggcaag gcctggggac acccgagatg       60

cctggttata attaacccag acatgtggct gctccccccc cccaacacct gctgcctgag      120

cctcaccccc accccggtgc ctgggtctta ggctctgtac accatggagg agaagctcgc      180

tctaaaaata accctgtccc tggtgggctg tgggggactg agggcaggct gtaacaggct      240

tgggggccag ggcttatacg tgcctgggac tcccaaagta ttactgttcc atgttcccgg      300

cgaagggcca gctgtccccc gccagctaga ctcagcactt agtttaggaa ccagtgagca      360

agtcagccct tggggcagcc catacaaggc catggggctg ggcaagctgc acgcctgggt      420

ccggggtggg cacggtgccc gggcaacgag ctgaaagctc atctgctctc aggggcccct      480

ccctggggac agcccctcct ggctagtcac accctgtagg ctcctctata taacccaggg      540

gcacaggggc tgcccccggg tcac                                             564


<210>  5
<211>  8409
<212>  DNA
<213>  Adeno associated virus

<400>  5
gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcgcg       60

ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc      120

cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc actaggggtt      180

ccttgtagtt aatgattaac ccgccatgct aattatctac gtagccatgt ctagacagcc      240

actatgggtc taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg      300

ttataattaa cccagacatg tggctgctcc ccccccccaa cacctgctgc ctgagcctca      360

cccccacccc ggtgcctggg tcttaggctc tgtacaccat ggaggagaag ctcgctctaa      420

aaataaccct gtccctggtg ggctgtgggg gactgagggc aggctgtaac aggcttgggg      480

gccagggctt atacgtgcct gggactccca aagtattact gttccatgtt cccggcgaag      540

ggccagctgt cccccgccag ctagactcag cacttagttt aggaaccagt gagcaagtca      600

gcccttgggg cagcccatac aaggccatgg ggctgggcaa gctgcacgcc tgggtccggg      660

gtgggcacgg tgcccgggca acgagctgaa agctcatctg ctctcagggg cccctccctg      720

gggacagccc ctcctggcta gtcacaccct gtaggctcct ctatataacc caggggcaca      780

ggggctgccc ccgggtcacc accacctcca cagcacagac agacactcag gagccagcca      840

gccaggtaag tttagtcttt ttgtctttta tttcaggtcc cggatccggt ggtggtgcaa      900

atcaaagaac tgctcctcag tggatgttgc ctttacttct aggcctgtac ggaagtgtta      960

cttctgctct aaaagctgcg gaattgtacc cgcggccgcc accatgctgt ggtgggagga     1020

ggtggaggat tgttatgaaa gggaggacgt gcagaagaag acttttacca agtgggtgaa     1080

cgctcagttc agcaaatttg ggaagcagca catcgagaat ctgttttccg acctgcagga     1140

tgggagacgg ctgctggatc tgctggaagg actgactggc cagaagctgc ccaaagagaa     1200

ggggagcact agggtgcacg ccctgaacaa cgtgaacaaa gctctgagag tgctgcagaa     1260

caacaacgtg gatctggtga atattggcag tactgatatc gtggacggga accacaaact     1320

gacactgggc ctgatctgga acattattct gcactggcag gtgaaaaatg tgatgaagaa     1380

catcatggcc gggctgcagc agaccaattc cgagaagatc ctgctgtctt gggtgcggca     1440

gagcacccgc aactatcccc aggtgaacgt gattaacttc actacatcct ggagcgacgg     1500

gctggccctg aatgctctga ttcacagcca caggcctgat ctgttcgact ggaatagcgt     1560

ggtgtgccag cagtctgcca cacagcgcct ggaacatgcc ttcaatatcg ctcggtacca     1620

gctggggatc gaaaaactgc tggacccaga ggatgtggac actacatacc cagataaaaa     1680

gtctattctg atgtacatta ctagcctgtt ccaggtgctg ccacagcagg tgtctattga     1740

agccattcag gaggtggaaa tgctgccccg cccccccaaa gtgactaaag aggagcattt     1800

tcagctgcat catcagatgc attacagcca gcagattacc gtgagcctgg ctcagggata     1860

tgagcgcacc agtagtccaa aaccacggtt caagtcctac gcttataccc aggctgccta     1920

cgtgacaact agcgacccta ctagatcccc ctttccatcc cagcacctgg aggccccaga     1980

ggacaagagc tttgggtcca gcctgatgga aagcgaggtg aatctggatc ggtaccagac     2040

agccctggag gaggtgctga gctggctgct gagtgctgaa gacacactgc aggcccaggg     2100

cgaaatttcc aatgacgtgg aagtggtgaa ggatcagttc cacacacacg agggctatat     2160

gatggacctg acagctcacc aggggcgcgt gggcaatatc ctgcagctgg gctctaaact     2220

gatcggcacc gggaaactga gtgaggacga ggaaacagaa gtgcaggagc agatgaacct     2280

gctgaacagc cgctgggagt gtctgagagt ggctagtatg gagaagcagt ccaacctgca     2340

ccgggtgctg atggacctgc agaaccagaa actgaaagag ctgaacgact ggctgacaaa     2400

gactgaggaa cgcacaagga agatggagga ggagccactg ggacccgacc tggaggatct     2460

gaagagacag gtgcagcagc ataaggtgct gcaggaggat ctggaacagg agcaggtgcg     2520

ggtgaactcc ctgacacata tggtggtggt ggtggacgaa tctagtggag atcacgccac     2580

cgccgccctg gaggaacagc tgaaggtgct gggggaccgg tgggccaaca tttgccggtg     2640

gaccgaggac aggtgggtgc tgctgcagga catcctgctg aaatggcaga ggctgaccga     2700

ggagcagtgt ctgtttagtg cttggctgag cgagaaagag gacgccgtga acaagatcca     2760

cacaaccggc tttaaggatc agaacgaaat gctgtctagc ctgcagaaac tggctgtgct     2820

gaaggccgat ctggagaaaa agaagcagag catgggcaaa ctgtatagcc tgaaacagga     2880

cctgctgagc accctgaaga acaagagcgt gacccagaag acagaagcct ggctggataa     2940

ctttgcccgc tgctgggaca acctggtgca gaaactggag aaaagtacag ctcagatctc     3000

tcaggctgtg accacaaccc agcctagcct gacccagaca accgtgatgg aaaccgtgac     3060

caccgtgaca acccgcgaac agatcctggt gaaacatgcc caggaagagc tgccacctcc     3120

acctccccag aagaagagaa ccctggagcg gctgcaggag ctgcaggaag ccactgacga     3180

actggacctg aagctgaggc aggccgaagt gattaagggg tcttggcagc ctgtgggcga     3240

tctgctgatt gattccctgc aggaccacct ggaaaaggtg aaggctctga gaggcgaaat     3300

tgctccactg aaggagaacg tgagtcatgt gaacgatctg gctagacagc tgacaacact     3360

gggcatccag ctgagcccat acaatctgag cacactggag gacctgaata ccaggtggaa     3420

gctgctgcag gtggctgtgg aagaccgggt gcggcagctg catgaggccc atcgcgactt     3480

cggaccagcc agccagcact ttctgagcac atccgtgcag gggccctggg agagggccat     3540

ttctcccaac aaggtgccct actatattaa tcacgagacc cagaccactt gttgggacca     3600

tcccaagatg acagaactgt accagtccct ggccgatctg aacaacgtga ggtttagcgc     3660

ttacagaacc gctatgaagc tgagacggct gcagaaggcc ctgtgcctgg atctgctgtc     3720

cctgtccgcc gcctgcgatg ccctggatca gcataatctg aagcagaacg atcagccaat     3780

ggatatcctg cagatcatca actgcctgac cactatctac gacaggctgg agcaggagca     3840

caacaacctg gtgaacgtgc ctctgtgcgt ggatatgtgc ctgaactggc tgctgaacgt     3900

gtatgacact gggcgcaccg gccggatcag agtgctgagt tttaaaactg ggattatctc     3960

cctgtgtaag gcccacctgg aggacaagta caggtacctg ttcaagcagg tggctagtag     4020

cactggattt tgtgaccagc gccgcctggg actgctgctg catgatagta tccagattcc     4080

tagacagctg ggagaggtgg ctagtttcgg aggatctaac atcgaaccca gcgtgcgcag     4140

ctgtttccag tttgccaata acaaacctga aatcgaggct gctctgttcc tggattggat     4200

gcgcctggaa ccacagagca tggtgtggct gcctgtgctg cacagagtgg ctgccgccga     4260

aactgccaag caccaggcta aatgcaacat ctgcaaggaa tgtcccatta tcggctttcg     4320

ctacaggagt ctgaaacatt ttaactacga tatttgccag agctgcttct tttccggaag     4380

agtggccaaa ggacacaaga tgcactaccc tatggtggaa tattgcaccc caactacatc     4440

tggcgaagat gtgcgcgatt ttgccaaggt gctgaagaat aagtttcgga ctaagaggta     4500

cttcgccaag cacccccgca tggggtatct gccagtgcag acagtgctgg aaggagacaa     4560

tatggagacc gatacaatgt gagcggccgc aataaaagat ctttattttc attagatctg     4620

tgtgttggtt ttttgtgtgt ctagagcatg gctacgtaga taagtagcat ggcgggttaa     4680

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     4740

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     4800

cagtgagcga gcgagcgcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct     4860

tcccaacagt tgcgcagcct gaatggcgaa tggaagttcc agacgattga gcgtcaaaat     4920

gtaggtattt ccatgagcgt ttttcctgtt gcaatggctg gcggtaatat tgttctggat     4980

attaccagca aggccgatag tttgagttct tctactcagg caagtgatgt tattactaat     5040

caaagaagta ttgcgacaac ggttaatttg cgtgatggac agactctttt actcggtggc     5100

ctcactgatt ataaaaacac ttctcaggat tctggcgtac cgttcctgtc taaaatccct     5160

ttaatcggcc tcctgtttag ctcccgctct gattctaacg aggaaagcac gttatacgtg     5220

ctcgtcaaag caaccatagt acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt     5280

ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt     5340

cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct     5400

ccctttaggg ttccgattta gtgatttacg gcacctcgac cccaaaaaac ttgattaggg     5460

tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga     5520

gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc     5580

ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga     5640

gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgttta caatttaaat     5700

atttgcttat acaatcttcc tgtttttggg gcttttctga ttatcaaccg gggtacatat     5760

gattgacatg ctagttttac gattaccgtt catcgattct cttgtttgct ccagactctc     5820

aggcaatgac ctgatagcct ttgtagagac ctctcaaaaa tagctaccct ctccggcatg     5880

aatttatcag ctagaacggt tgaatatcat attgatggtg atttgactgt ctccggcctt     5940

tctcacccgt ttgaatcttt acctacacat tactcaggca ttgcatttaa aatatatgag     6000

ggttctaaaa atttttatcc ttgcgttgaa ataaaggctt ctcccgcaaa agtattacag     6060

ggtcataatg tttttggtac aaccgattta gctttatgct ctgaggcttt attgcttaat     6120

tttgctaatt ctttgccttg cctgtatgat ttattggatg ttggaagttc ctgatgcggt     6180

attttctcct tacgcatctg tgcggtattt cacaccgcat atggtgcact ctcagtacaa     6240

tctgctctga tgccgcatag ttaagccagc cccgacaccc gccaacaccc gctgacgcgc     6300

cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc gtctccggga     6360

gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgagacga aagggcctcg     6420

tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag acgtcaggtg     6480

gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa     6540

atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga     6600

agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc     6660

ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg     6720

gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc     6780

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat     6840

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg     6900

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag     6960

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa     7020

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc     7080

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca     7140

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc     7200

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc     7260

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg     7320

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta     7380

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag     7440

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga     7500

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc     7560

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa     7620

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa     7680

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     7740

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta gtgtagccgt     7800

agttaggcca ccacttcaag aactctgtag caccgcgtac atacctcgct ctgctaatcc     7860

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     7920

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     7980

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     8040

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     8100

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     8160

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     8220

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     8280

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gggtttgagt     8340

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaccaag     8400

cggaagagc                                                             8409


