                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  METHODS OF TREATING LYSOSOMAL DISORDERS

<130>  20378-201753

<150>  62/471,741
<151>  2017-03-05

<150>  62/507,713
<151>  2017-05-17

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  367
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ile Arg Asn Trp Leu Thr Ile Phe Ile Leu Phe Pro Leu Lys Leu 
1               5                   10                  15      


Val Glu Lys Cys Glu Ser Ser Val Ser Leu Thr Val Pro Pro Val Val 
            20                  25                  30          


Lys Leu Glu Asn Gly Ser Ser Thr Asn Val Ser Leu Thr Leu Arg Pro 
        35                  40                  45              


Pro Leu Asn Ala Thr Leu Val Ile Thr Phe Glu Ile Thr Phe Arg Ser 
    50                  55                  60                  


Lys Asn Ile Thr Ile Leu Glu Leu Pro Asp Glu Val Val Val Pro Pro 
65                  70                  75                  80  


Gly Val Thr Asn Ser Ser Phe Gln Val Thr Ser Gln Asn Val Gly Gln 
                85                  90                  95      


Leu Thr Val Tyr Leu His Gly Asn His Ser Asn Gln Thr Gly Pro Arg 
            100                 105                 110         


Ile Arg Phe Leu Val Ile Arg Ser Ser Ala Ile Ser Ile Ile Asn Gln 
        115                 120                 125             


Val Ile Gly Trp Ile Tyr Phe Val Ala Trp Ser Ile Ser Phe Tyr Pro 
    130                 135                 140                 


Gln Val Ile Met Asn Trp Arg Arg Lys Ser Val Ile Gly Leu Ser Phe 
145                 150                 155                 160 


Asp Phe Val Ala Leu Asn Leu Thr Gly Phe Val Ala Tyr Ser Val Phe 
                165                 170                 175     


Asn Ile Gly Leu Leu Trp Val Pro Tyr Ile Lys Glu Gln Phe Leu Leu 
            180                 185                 190         


Lys Tyr Pro Asn Gly Val Asn Pro Val Asn Ser Asn Asp Val Phe Phe 
        195                 200                 205             


Ser Leu His Ala Val Val Leu Thr Leu Ile Ile Ile Val Gln Cys Cys 
    210                 215                 220                 


Leu Tyr Glu Arg Gly Gly Gln Arg Val Ser Trp Pro Ala Ile Gly Phe 
225                 230                 235                 240 


Leu Val Leu Ala Trp Leu Phe Ala Phe Val Thr Met Ile Val Ala Ala 
                245                 250                 255     


Val Gly Val Ile Thr Trp Leu Gln Phe Leu Phe Cys Phe Ser Tyr Ile 
            260                 265                 270         


Lys Leu Ala Val Thr Leu Val Lys Tyr Phe Pro Gln Ala Tyr Met Asn 
        275                 280                 285             


Phe Tyr Tyr Lys Ser Thr Glu Gly Trp Ser Ile Gly Asn Val Leu Leu 
    290                 295                 300                 


Asp Phe Thr Gly Gly Ser Phe Ser Leu Leu Gln Met Phe Leu Gln Ser 
305                 310                 315                 320 


Tyr Asn Asn Asp Gln Trp Thr Leu Ile Phe Gly Asp Pro Thr Lys Phe 
                325                 330                 335     


Gly Leu Gly Val Phe Ser Ile Val Phe Asp Val Val Phe Phe Ile Gln 
            340                 345                 350         


His Phe Cys Leu Tyr Arg Lys Arg Pro Gly Tyr Asp Gln Leu Asn 
        355                 360                 365         


<210>  2
<211>  2611
<212>  DNA
<213>  homo sapiens

<400>  2
cgcctctccc aaagtctagc cgggcagggg aacgcggtgc attcctgacc ggcacctggc       60

gaggctcatg cgtcccgtga gggcggttcc tcgagcctgg gggcgctcag attgctttgg      120

agacgctgag agaacctttg cgagagcgcc ggttgacgtg cggagtgcgg ggctccgggg      180

gactgagcag cacgagaccc catcctcccc tccgggtttt cacactgggc gaagggagga      240

ctcctgagct ctgcctcttc cagtaacatt gaggattact gtgttttgtg agagctcgct      300

aggcgcccta agcaacagag ttctgagaaa tcgagaaaca tgataaggaa ttggctgact      360

atttttatcc tttttcccct gaagctcgta gagaaatgtg agtcaagcgt cagcctcact      420

gttcctcctg tcgtaaagct ggagaacggc agctcgacca acgtcagcct caccctgcgg      480

ccaccattaa atgcaaccct ggtgatcact tttgaaatca catttcgttc caaaaatatt      540

actatccttg agctccccga tgaagttgtg gtgcctcctg gagtgacaaa ctcctctttt      600

caagtgacat ctcaaaatgt tggacaactt actgtttatc tacatggaaa tcactccaat      660

cagaccggcc cgaggatacg ctttcttgtg atccgcagca gcgccattag catcataaac      720

caggtgattg gctggatcta ctttgtggcc tggtccatct ccttctaccc tcaggtgatc      780

atgaattgga ggcggaaaag tgtcattggt ctgagcttcg acttcgtggc tctgaacctg      840

acaggcttcg tggcctacag tgtattcaac atcggcctcc tctgggtgcc ctacatcaag      900

gagcagtttc tcctcaaata ccccaacgga gtgaaccccg tgaacagcaa cgacgtcttc      960

ttcagcctgc acgcggttgt cctcacgctg atcatcatcg tgcagtgctg cctgtatgag     1020

cgcggtggcc agcgcgtgtc ctggcctgcc atcggcttcc tggtgctcgc gtggctcttc     1080

gcatttgtca ccatgatcgt ggctgcagtg ggagtgatca cgtggctgca gtttctcttc     1140

tgcttctcct acatcaagct cgcagtcacg ctggtcaagt attttccaca ggcctacatg     1200

aacttttact acaaaagcac tgagggctgg agcattggca acgtgctcct ggacttcacc     1260

gggggcagct tcagcctcct gcagatgttc ctccagtcct acaacaacga ccagtggacg     1320

ctgatcttcg gagacccaac caagtttgga ctcggggtct tctccatcgt cttcgacgtc     1380

gtcttcttca tccagcactt ctgtttgtac agaaagagac cggggtatga ccagctgaac     1440

tagcacccag ggacccagtg tacccagcct ctggcctcgt gccctgctgg ggaaggcctc     1500

acccagcgaa ggccggagaa gcggttgggc cctggcacac agggctggct cagtgtgcgg     1560

acagaggaga ccactctgct cctggggcca gaggccattc aatagcctgc cttcgtccgg     1620

gcccctcctg ggcctccccg gccaggcacg tggcaccgtc gccttgacac cgccatctct     1680

tttctttaag gcttcaggca gcgcgcacag gctctggcag ccgtctcagg caggactggg     1740

caccaagctt gcagccgaag gccttgcccc aaactaccag cgtttctgca agcagcttga     1800

agggctgacc ttgcagccgg gtgagccaag ggcactttgc tgccaccgct gcattcccag     1860

agatcaagca gcccggtgcc gtggccagtg aactcagagg tgctggtgga cgggctagga     1920

ctttggggtt aggccatggg gctctttctc tgaaggccac tttcctgacg tactctctgt     1980

acataactca gcgtccgtga ctgcagtaac agccagccct acccagagta tttctgagcc     2040

atgaggggcc caccagattg gttctgaatt ggattcatgc ccagcgcatt agcatagtaa     2100

ctcctttcag attttttgga gggacgtttg gaagtggctt actctcttct gccctctctc     2160

ctacctccac cttctcagat gagccccatc tgagcacatc cagctgctcc ttacccagca     2220

tctggagtac aggacatagc tctctcctgc taccagtctg tgccttagag gtcgttaggc     2280

ctgccaaacg gcgaccagct cccctggagc gagggcaggc cccttccctc tctttcccca     2340

gacacctact tgagactcac caatttctgg cctgttcagg agcctcagat aagtatttgt     2400

acttgagacc acctcacaca atctgtatgg gcccaaccct gatctcaaac ctccttccct     2460

ctgcccaaag ctgtccttcc tatggcagga ggggtggggg tcccaggacg tgcctcatac     2520

atgacttgag cttgtcagtc cactgagttt ccttctacga gatcaacgcg aggggcctgt     2580

atcttgaatt aaagcctact cgcttccttt c                                    2611


<210>  3
<211>  495
<212>  PRT
<213>  homo sapiens

<400>  3

Met Arg Ser Pro Val Arg Asp Leu Ala Arg Asn Asp Gly Glu Glu Ser 
1               5                   10                  15      


Thr Asp Arg Thr Pro Leu Leu Pro Gly Ala Pro Arg Ala Glu Ala Ala 
            20                  25                  30          


Pro Val Cys Cys Ser Ala Arg Tyr Asn Leu Ala Ile Leu Ala Phe Phe 
        35                  40                  45              


Gly Phe Phe Ile Val Tyr Ala Leu Arg Val Asn Leu Ser Val Ala Leu 
    50                  55                  60                  


Val Asp Met Val Asp Ser Asn Thr Thr Leu Glu Asp Asn Arg Thr Ser 
65                  70                  75                  80  


Lys Ala Cys Pro Glu His Ser Ala Pro Ile Lys Val His His Asn Gln 
                85                  90                  95      


Thr Gly Lys Lys Tyr Gln Trp Asp Ala Glu Thr Gln Gly Trp Ile Leu 
            100                 105                 110         


Gly Ser Phe Phe Tyr Gly Tyr Ile Ile Thr Gln Ile Pro Gly Gly Tyr 
        115                 120                 125             


Val Ala Ser Lys Ile Gly Gly Lys Met Leu Leu Gly Phe Gly Ile Leu 
    130                 135                 140                 


Gly Thr Ala Val Leu Thr Leu Phe Thr Pro Ile Ala Ala Asp Leu Gly 
145                 150                 155                 160 


Val Gly Pro Leu Ile Val Leu Arg Ala Leu Glu Gly Leu Gly Glu Gly 
                165                 170                 175     


Val Thr Phe Pro Ala Met His Ala Met Trp Ser Ser Trp Ala Pro Pro 
            180                 185                 190         


Leu Glu Arg Ser Lys Leu Leu Ser Ile Ser Tyr Ala Gly Ala Gln Leu 
        195                 200                 205             


Gly Thr Val Ile Ser Leu Pro Leu Ser Gly Ile Ile Cys Tyr Tyr Met 
    210                 215                 220                 


Asn Trp Thr Tyr Val Phe Tyr Phe Phe Gly Thr Ile Gly Ile Phe Trp 
225                 230                 235                 240 


Phe Leu Leu Trp Ile Trp Leu Val Ser Asp Thr Pro Gln Lys His Lys 
                245                 250                 255     


Arg Ile Ser His Tyr Glu Lys Glu Tyr Ile Leu Ser Ser Leu Arg Asn 
            260                 265                 270         


Gln Leu Ser Ser Gln Lys Ser Val Pro Trp Val Pro Ile Leu Lys Ser 
        275                 280                 285             


Leu Pro Leu Trp Ala Ile Val Val Ala His Phe Ser Tyr Asn Trp Thr 
    290                 295                 300                 


Phe Tyr Thr Leu Leu Thr Leu Leu Pro Thr Tyr Met Lys Glu Ile Leu 
305                 310                 315                 320 


Arg Phe Asn Val Gln Glu Asn Gly Phe Leu Ser Ser Leu Pro Tyr Leu 
                325                 330                 335     


Gly Ser Trp Leu Cys Met Ile Leu Ser Gly Gln Ala Ala Asp Asn Leu 
            340                 345                 350         


Arg Ala Lys Trp Asn Phe Ser Thr Leu Cys Val Arg Arg Ile Phe Ser 
        355                 360                 365             


Leu Ile Gly Met Ile Gly Pro Ala Val Phe Leu Val Ala Ala Gly Phe 
    370                 375                 380                 


Ile Gly Cys Asp Tyr Ser Leu Ala Val Ala Phe Leu Thr Ile Ser Thr 
385                 390                 395                 400 


Thr Leu Gly Gly Phe Cys Ser Ser Gly Phe Ser Ile Asn His Leu Asp 
                405                 410                 415     


Ile Ala Pro Ser Tyr Ala Gly Ile Leu Leu Gly Ile Thr Asn Thr Phe 
            420                 425                 430         


Ala Thr Ile Pro Gly Met Val Gly Pro Val Ile Ala Lys Ser Leu Thr 
        435                 440                 445             


Pro Asp Asn Thr Val Gly Glu Trp Gln Thr Val Phe Tyr Ile Ala Ala 
    450                 455                 460                 


Ala Ile Asn Val Phe Gly Ala Ile Phe Phe Thr Leu Phe Ala Lys Gly 
465                 470                 475                 480 


Glu Val Gln Asn Trp Ala Leu Asn Asp His His Gly His Arg His 
                485                 490                 495 


<210>  4
<211>  2512
<212>  DNA
<213>  homo sapiens

<400>  4
cggctacttt gcgccaatcc tacgagaact cccagaactc cgcttcccta gtccaaccca       60

agccagagtt gcccacacct aagatggcgg cggggggcgg agtcggcgcg gccgcctctg      120

ggcgggaccg cggggactag acgtggccgc ggggcggtgt catcgccccc gccccgcccg      180

gtccagccag ctcggcccgg gggcttcggg ctgtcgggcc ggcgctccct tctctgccag      240

gtggcgagta cacctgctca cgtaggcgtc atgaggtctc cggttcgaga cctggcccgg      300

aacgatggcg aggagagcac ggaccgcacg cctcttctac cgggcgcccc acgggccgaa      360

gccgctccag tgtgctgctc tgctcgttac aacttagcaa ttttggcctt ttttggtttc      420

ttcattgtgt atgcattacg tgtgaatctg agtgttgcgt tagtggatat ggtagattca      480

aatacaactt tagaagataa tagaacttcc aaggcgtgtc cagagcattc tgctcccata      540

aaagttcatc ataatcaaac gggtaagaag taccaatggg atgcagaaac tcaaggatgg      600

attctcggtt ccttttttta tggctacatc atcacacaga ttcctggagg atatgttgcc      660

agcaaaatag gggggaaaat gctgctagga tttgggatcc ttggcactgc tgtcctcacc      720

ctgttcactc ccattgctgc agatttagga gttggaccac tcattgtact cagagcacta      780

gaaggactag gagagggtgt tacatttcca gccatgcatg ccatgtggtc ttcttgggct      840

ccccctcttg aaagaagcaa acttcttagc atttcatatg caggagcaca gcttgggaca      900

gtaatttctc ttcctctttc tggaataatt tgctactata tgaattggac ttatgtcttc      960

tacttttttg gtactattgg aatattttgg tttcttttgt ggatctggtt agttagtgac     1020

acaccacaaa aacacaagag aatttcccat tatgaaaagg aatacattct ttcatcatta     1080

agaaatcagc tttcttcaca gaagtcagtg ccgtgggtac ccattttaaa atccctgcca     1140

ctttgggcta tcgtagttgc acacttttct tacaactgga ctttttatac tttattgaca     1200

ttattgccta cttatatgaa ggagatccta aggttcaatg ttcaagagaa tgggttttta     1260

tcttcattgc cttatttagg ctcttggtta tgtatgatcc tgtctggtca agctgctgac     1320

aatttaaggg caaaatggaa tttttcaact ttatgtgttc gcagaatttt tagccttata     1380

ggaatgattg gacctgcagt attcctggta gctgctggct tcattggctg tgattattct     1440

ttggccgttg ctttcctaac tatatcaaca acactgggag gcttttgctc ttctggattt     1500

agcatcaacc atctggatat tgctccttcg tatgctggta tcctcctggg catcacaaat     1560

acatttgcca ctattccagg aatggttggg cccgtcattg ctaaaagtct gacccctgat     1620

aacactgttg gagaatggca aaccgtgttc tatattgctg ctgctattaa tgtttttggt     1680

gccattttct ttacactatt cgccaaaggt gaagtacaaa actgggctct caatgatcac     1740

catggacaca gacactgaag gaaccaataa ataatcctgc ctctattaat gtatttttat     1800

ttatcatgta acctcaaagt gccttctgta ttgtgtaagc attctatgtc tttttttaat     1860

tgtacttgta ttagattttt aaggcctata atcatgaaat atcactagtt gccagaataa     1920

taaaatgaac tgtgtttaat tatgaataat atgtaagcta ggacttctac tttaggttca     1980

catacctgcc tgctagtcgg gcaacatgaa gtaggacagt tctgttgatt ttttagggcc     2040

atactaaagg gaatgagctg aaacagacct cctgatacct ttgcttaatt aaactagatg     2100

ataattctca ggtactgata aacacctgtt gttgttcact ttcctcataa aaattgtcag     2160

ctctctctga cacttagacc tcaaacttta gcatctctgt ggagctgcca tccactgtat     2220

aatttcgcct ggcaactgga ctgaggggag tgtgcccagg cagctgccaa gcactccctc     2280

cctggcttca gggtcagagt gcccagcgtt tatcagaggc agcatccaag cccagagcca     2340

gtgtcgactc ttcggctggt gcctttcctc tgaggggcta tcaatgtgta gataaagccc     2400

tgagtaggca agagcagtga gatccactgc tatggtcttg atacatcctc aaactttccc     2460

ttcccagcac agaggaatat tggctggcat gcaacctgca aaagaaaaat gc             2512


<210>  5
<211>  537
<212>  PRT
<213>  homo sapiens

<400>  5

Gly Ala Ala Ser Ala Glu Leu Val Ile Gly Trp Cys Ile Phe Gly Pro 
1               5                   10                  15      


Leu Leu Leu Ala Ile Phe Ala Phe Cys Trp Ile Tyr Val Arg Lys Tyr 
            20                  25                  30          


Gln Ser Gln Arg Glu Ser Glu Val Val Ser Thr Ile Thr Ala Ile Phe 
        35                  40                  45              


Ser Leu Ala Ile Ala Leu Ile Thr Ser Ala Leu Leu Pro Val Asp Ile 
    50                  55                  60                  


Phe Leu Val Ser Tyr Met Lys Asn Gln Asn Gly Thr Phe Lys Asp Trp 
65                  70                  75                  80  


Ala Asn Ala Asn Val Ser Arg Gln Ile Glu Asp Thr Val Leu Tyr Gly 
                85                  90                  95      


Tyr Tyr Thr Leu Tyr Ser Val Ile Leu Phe Cys Val Phe Phe Trp Ile 
            100                 105                 110         


Pro Phe Val Tyr Phe Tyr Tyr Glu Glu Lys Asp Asp Asp Asp Thr Ser 
        115                 120                 125             


Lys Cys Thr Gln Ile Lys Thr Ala Phe Lys Tyr Thr Leu Gly Phe Ala 
    130                 135                 140                 


Val Ile Cys Ala Leu Leu Leu Leu Val Gly Ala Phe Val Pro Leu Asn 
145                 150                 155                 160 


Val Pro Asn Asn Lys Asn Ser Thr Glu Trp Glu Lys Val Lys Phe Leu 
                165                 170                 175     


Phe Glu Glu Leu Gly Ser Ser His Gly Leu Ala Ala Leu Ser Phe Ser 
            180                 185                 190         


Ile Ser Ser Leu Thr Leu Ile Gly Met Leu Ala Ala Ile Thr Tyr Thr 
        195                 200                 205             


Ala Tyr Gly Met Ser Ala Leu Pro Leu Asn Leu Ile Lys Gly Thr Arg 
    210                 215                 220                 


Ser Ala Ala Tyr Glu Arg Leu Glu Asn Thr Glu Asp Ile Glu Glu Val 
225                 230                 235                 240 


Glu Gln His Ile Gln Thr Ile Lys Ser Lys Ser Lys Asp Gly Arg Pro 
                245                 250                 255     


Leu Pro Ala Arg Asp Lys Arg Ala Leu Lys Gln Phe Glu Glu Arg Leu 
            260                 265                 270         


Arg Thr Leu Arg Lys Arg Glu Arg His Leu Glu Tyr Ile Glu Asn Ser 
        275                 280                 285             


Trp Trp Thr Lys Phe Cys Gly Ala Leu Arg Pro Leu Lys Ile Ile Trp 
    290                 295                 300                 


Gly Ile Phe Phe Ile Leu Val Ala Leu Leu Phe Ile Ile Ser Leu Phe 
305                 310                 315                 320 


Leu Ser Asn Leu Asp Lys Ala Leu His Ser Ala Gly Ile Asp Ser Gly 
                325                 330                 335     


Phe Ile Ile Phe Gly Ala Asn Leu Ser Asn Pro Leu Asn Met Leu Leu 
            340                 345                 350         


Pro Val Leu Gln Thr Val Phe Pro Leu Asp Tyr Ile Leu Ile Thr Ile 
        355                 360                 365             


Ile Ile Met Tyr Phe Ile Phe Thr Ser Met Ala Gly Ile Arg Asn Ile 
    370                 375                 380                 


Gly Ile Trp Phe Phe Trp Val Arg Leu Tyr Lys Ile Arg Arg Gly Arg 
385                 390                 395                 400 


Thr Arg Pro Gln Ala Leu Leu Phe Leu Cys Met Ile Leu Leu Leu Ile 
                405                 410                 415     


Val Leu His Thr Ser Tyr Met Ile Tyr Ser Leu Ala Pro Gln Tyr Val 
            420                 425                 430         


Met Tyr Gly Ser Gln Asn Tyr Leu Ile Glu Ser Asn Ile Thr Tyr Asp 
        435                 440                 445             


Asp His Lys Asn Asn Ser Ala Phe Pro Val Pro Lys Arg Cys Asp Ala 
    450                 455                 460                 


Asp Ala Pro Glu Asp Gln Cys Thr Val Thr Arg Thr Tyr Leu Phe Leu 
465                 470                 475                 480 


His Lys Phe Trp Phe Phe Ser Ala Ala Tyr Tyr Phe Gly Asn Trp Ala 
                485                 490                 495     


Phe Leu Val Val Phe Leu Ile Gly Leu Ile Val Ser Cys Cys Lys Gly 
            500                 505                 510         


Lys Lys Ser Val Ile Glu Gly Val Asp Glu Asp Asp Ser Asp Ile Ser 
        515                 520                 525             


Asp Asp Glu Pro Ser Val Tyr Ser Val 
    530                 535         


<210>  6
<211>  1979
<212>  DNA
<213>  homo sapiens

<400>  6
ggcgcggctt cggcggagct ggtgatcggc tggtgcatat ttggcccctt actactggct       60

atttttgcat tctgttggat atatgttcgt aaataccaaa gtcagcggga aagtgaagtt      120

gtctccacca taacggcaat tttttctctg gcgattgcac ttatcacatc agcacttctt      180

ccagtggata tatttttggt ttcttacatg aaaaatcaaa atggtacatt taaggactgg      240

gccaatgcta atgtcagcag acagatcgag gacactgtgt tatatggtta ctacacctta      300

tattctgtta tattattctg tgtgtttttc tggatccctt ttgtctactt ctactatgaa      360

gaaaaggatg atgatgatac tagtaaatgt actcaaatta aaactgcatt caagtatact      420

ttgggatttg ctgtaatttg tgcacttctt cttttagttg gagcttttgt tcctctaaat      480

gttcctaata acaaaaattc tacagagtgg gaaaaagtga agttcctgtt tgaagaactt      540

ggaagtagtc atggtttagc tgcattgtca ttttctatta gttctctgac cttgattgga      600

atgttggcag ctataactta cacagcctat ggcatgtctg cattaccttt aaatctaata      660

aaaggcacta gaagcgctgc ttacgaacgt ttagaaaaca ctgaagacat tgaagaagtg      720

gagcaacaca ttcaaacgat taaatcaaaa agcaaagatg gtcggccttt gccagcaagg      780

gataaacgcg ccttaaaaca atttgaagaa aggttaagaa cacttaggaa aagagagagg      840

cacttagaat acattgaaaa cagctggtgg acaaaatttt gtggtgctct gcgtcccctg      900

aagatcattt ggggaatatt tttcatctta gttgcattgc tgtttataat ttctctcttc      960

ctgtcaaatt tggataaagc ccttcattca gctggaatag attctggttt tataattttt     1020

ggagctaact tgagtaatcc actgaatatg cttttgcctg tactacaaac agtgtttcct     1080

cttgattata ttcttataac aattattatt atgtacttta tttttacttc aatggcggga     1140

attcgaaata tcggcatatg gttcttttgg gttagactat ataaaattag aagaggtaga     1200

accaggcccc aggccctctt atttctttgc atgatacttc tgcttattgt ccttcacact     1260

agctacatga tttatagtct tgctccccaa tatgtcatgt atggaagcca aaattactta     1320

atagagagca atataactta tgatgaccat aaaaacaatt cagccttccc tgtgccaaag     1380

agatgtgatg ctgatgcccc tgaagaccaa tgtactgtta cgcggacata cctgttcctt     1440

cacaagttct ggttctttag tgctgcatac tattttggta actgggcttt tcttgtggta     1500

ttcttgattg gattaattgt atcctgttgt aaagggaaga aatcagtcat tgaaggagta     1560

gatgaagatg attcagacat aagtgatgat gagccctctg tctattctgt ttgagagcct     1620

ctgtcttagg ggttttataa tgctgactga atgtctatta tgcatttttt aaagtgttaa     1680

actaacatta ggatgaactg actagcttca tcaaaaatgg gagcatggct attaaaaaaa     1740

ctatattttt tatgttatct gaagtaacat tattgtatca tagattaaca tttaaaattg     1800

ctgtaataat tctatgtaaa tataaaacta tggactttgt gagggaatgt ttgtggaaat     1860

cttttttctc tagtgtataa tagtgttgaa ttgattaaaa gtcttccaga attaatattc     1920

cctcttgtca cttcttaaaa acataataaa tcacttctac ctgtgcaaaa aaaaaaaaa      1979


<210>  7
<211>  518
<212>  PRT
<213>  homo sapiens

<400>  7

Met Ala Gly Leu Arg Asn Glu Ser Glu Gln Glu Pro Leu Leu Gly Asp 
1               5                   10                  15      


Thr Pro Gly Ser Arg Glu Trp Asp Ile Leu Glu Thr Glu Glu His Tyr 
            20                  25                  30          


Lys Ser Arg Trp Arg Ser Ile Arg Ile Leu Tyr Leu Thr Met Phe Leu 
        35                  40                  45              


Ser Ser Val Gly Phe Ser Val Val Met Met Ser Ile Trp Pro Tyr Leu 
    50                  55                  60                  


Gln Lys Ile Asp Pro Thr Ala Asp Thr Ser Phe Leu Gly Trp Val Ile 
65                  70                  75                  80  


Ala Ser Tyr Ser Leu Gly Gln Met Val Ala Ser Pro Ile Phe Gly Leu 
                85                  90                  95      


Trp Ser Asn Tyr Arg Pro Arg Lys Glu Pro Leu Ile Val Ser Ile Leu 
            100                 105                 110         


Ile Ser Val Ala Ala Asn Cys Leu Tyr Ala Tyr Leu His Ile Pro Ala 
        115                 120                 125             


Ser His Asn Lys Tyr Tyr Met Leu Val Ala Arg Gly Leu Leu Gly Ile 
    130                 135                 140                 


Gly Ala Gly Asn Val Ala Val Val Arg Ser Tyr Thr Ala Gly Ala Thr 
145                 150                 155                 160 


Ser Leu Gln Glu Arg Thr Ser Ser Met Ala Asn Ile Ser Met Cys Gln 
                165                 170                 175     


Ala Leu Gly Phe Ile Leu Gly Pro Val Phe Gln Thr Cys Phe Thr Phe 
            180                 185                 190         


Leu Gly Glu Lys Gly Val Thr Trp Asp Val Ile Lys Leu Gln Ile Asn 
        195                 200                 205             


Met Tyr Thr Thr Pro Val Leu Leu Ser Ala Phe Leu Gly Ile Leu Asn 
    210                 215                 220                 


Ile Ile Leu Ile Leu Ala Ile Leu Arg Glu His Arg Val Asp Asp Ser 
225                 230                 235                 240 


Gly Arg Gln Cys Lys Ser Ile Asn Phe Glu Glu Ala Ser Thr Asp Glu 
                245                 250                 255     


Ala Gln Val Pro Gln Gly Asn Ile Asp Gln Val Ala Val Val Ala Ile 
            260                 265                 270         


Asn Val Leu Phe Phe Val Thr Leu Phe Ile Phe Ala Leu Phe Glu Thr 
        275                 280                 285             


Ile Ile Thr Pro Leu Thr Met Asp Met Tyr Ala Trp Thr Gln Glu Gln 
    290                 295                 300                 


Ala Val Leu Tyr Asn Gly Ile Ile Leu Ala Ala Leu Gly Val Glu Ala 
305                 310                 315                 320 


Val Val Ile Phe Leu Gly Val Lys Leu Leu Ser Lys Lys Ile Gly Glu 
                325                 330                 335     


Arg Ala Ile Leu Leu Gly Gly Leu Ile Val Val Trp Val Gly Phe Phe 
            340                 345                 350         


Ile Leu Leu Pro Trp Gly Asn Gln Phe Pro Lys Ile Gln Trp Glu Asp 
        355                 360                 365             


Leu His Asn Asn Ser Ile Pro Asn Thr Thr Phe Gly Glu Ile Ile Ile 
    370                 375                 380                 


Gly Leu Trp Lys Ser Pro Met Glu Asp Asp Asn Glu Arg Pro Thr Gly 
385                 390                 395                 400 


Cys Ser Ile Glu Gln Ala Trp Cys Leu Tyr Thr Pro Val Ile His Leu 
                405                 410                 415     


Ala Gln Phe Leu Thr Ser Ala Val Leu Ile Gly Leu Gly Tyr Pro Val 
            420                 425                 430         


Cys Asn Leu Met Ser Tyr Thr Leu Tyr Ser Lys Ile Leu Gly Pro Lys 
        435                 440                 445             


Pro Gln Gly Val Tyr Met Gly Trp Leu Thr Ala Ser Gly Ser Gly Ala 
    450                 455                 460                 


Arg Ile Leu Gly Pro Met Phe Ile Ser Gln Val Tyr Ala His Trp Gly 
465                 470                 475                 480 


Pro Arg Trp Ala Phe Ser Leu Val Cys Gly Ile Ile Val Leu Thr Ile 
                485                 490                 495     


Thr Leu Leu Gly Val Val Tyr Lys Arg Leu Ile Ala Leu Ser Val Arg 
            500                 505                 510         


Tyr Gly Arg Ile Gln Glu 
        515             


<210>  8
<211>  1909
<212>  DNA
<213>  homo sapiens

<400>  8
aggttacaag cagcagatcc caccttcagt cctggctctg acaagccctc cagcttcacg       60

ccacccggga tgggagaaag caggtgtcgc gagagttggg cgcaagacgc cttgtaggga      120

gtgtaactat ggccggcctg cggaacgaaa gtgaacagga gccgctctta ggcgacacac      180

ctggaagcag agaatgggac attttagaga ctgaagagca ttataagagc cgatggagat      240

ctattaggat tttatatctt actatgtttc tcagcagtgt agggttttct gtagtgatga      300

tgtccatatg gccatatctc caaaagattg atccgacagc tgatacaagt tttttgggct      360

gggttattgc ttcatatagt cttggccaaa tggtagcttc acctatattt ggtttatggt      420

ctaattatag accaagaaaa gagcctctta ttgtctccat cttgatttcc gtggcagcca      480

actgcctcta tgcatatctc cacatcccag cttctcataa taaatactac atgctggttg      540

ctcgtggatt gttgggaatt ggagcaggaa atgtagcagt tgttagatca tatactgctg      600

gtgctacttc ccttcaggaa agaacaagtt ccatggcaaa cataagcatg tgtcaagcat      660

taggttttat tctaggtcca gtttttcaga cttgttttac attccttgga gaaaaaggtg      720

tgacatggga tgtgattaaa ctgcagataa acatgtatac aacaccagtt ttacttagcg      780

ccttcctggg aattttaaat attattctga tccttgccat actaagagaa catcgtgtgg      840

atgactcagg aagacagtgt aaaagtatta attttgaaga agcaagtaca gatgaagctc      900

aggttcccca aggaaatatt gaccaggttg ctgttgtggc catcaatgtt ctgttttttg      960

tgactctatt tatctttgcc ctttttgaaa ccatcattac tccattaaca atggatatgt     1020

atgcctggac tcaagaacaa gctgtgttat ataatggcat aatacttgct gctcttgggg     1080

ttgaagccgt tgttattttc ttaggagtta agttgctttc caaaaagatt ggcgagcgtg     1140

ctattctact gggaggactc atcgttgtat gggttggctt ctttatcttg ttaccttggg     1200

gaaatcaatt tcccaaaata cagtgggaag atttgcacaa taattcaatc cctaatacca     1260

catttgggga aattattatt ggtctttgga agtctccaat ggaagatgac aatgaaagac     1320

caactggttg ctcgattgaa caagcctggt gcctctacac cccggtgatt catctggccc     1380

agttccttac atcagctgtg ctaataggat taggctatcc agtctgcaat cttatgtcct     1440

atactctata ttcaaaaatt ctaggaccaa aacctcaggg tgtatacatg ggctggttaa     1500

cagcatctgg aagtggagcc cggattcttg ggcctatgtt catcagccaa gtgtatgctc     1560

actggggacc acgatgggca ttcagcctgg tgtgtggaat aatagtgctc accatcaccc     1620

tcctgggagt ggtttacaaa agactcattg ctctttctgt aagatatggg aggattcagg     1680

aataaactag ctaagactgt gatggaaact acttgctgtg tggcacttcc tggtctaaag     1740

ctctgctaga caattgcggt gagccagtct ccaagaatca gactacagat attgcagatt     1800

ttgaagaaca agaacatatg ttgaataaca gagagaattc tacatgtcat tgtgaatagt     1860

aggttatata aaaacatact agatgataat ttcaaaaaaa aaaaaaaaa                 1909


<210>  9
<211>  438
<212>  PRT
<213>  homo sapiens

<400>  9

Met Gly Gly Cys Ala Gly Ser Arg Arg Arg Phe Ser Asp Ser Glu Gly 
1               5                   10                  15      


Glu Glu Thr Val Pro Glu Pro Arg Leu Pro Leu Leu Asp His Gln Gly 
            20                  25                  30          


Ala His Trp Lys Asn Ala Val Gly Phe Trp Leu Leu Gly Leu Cys Asn 
        35                  40                  45              


Asn Phe Ser Tyr Val Val Met Leu Ser Ala Ala His Asp Ile Leu Ser 
    50                  55                  60                  


His Lys Arg Thr Ser Gly Asn Gln Ser His Val Asp Pro Gly Pro Thr 
65                  70                  75                  80  


Pro Ile Pro His Asn Ser Ser Ser Arg Phe Asp Cys Asn Ser Val Ser 
                85                  90                  95      


Thr Ala Ala Val Leu Leu Ala Asp Ile Leu Pro Thr Leu Val Ile Lys 
            100                 105                 110         


Leu Leu Ala Pro Leu Gly Leu His Leu Leu Pro Tyr Ser Pro Arg Val 
        115                 120                 125             


Leu Val Ser Gly Ile Cys Ala Ala Gly Ser Phe Val Leu Val Ala Phe 
    130                 135                 140                 


Ser His Ser Val Gly Thr Ser Leu Cys Gly Val Val Phe Ala Ser Ile 
145                 150                 155                 160 


Ser Ser Gly Leu Gly Glu Val Thr Phe Leu Ser Leu Thr Ala Phe Tyr 
                165                 170                 175     


Pro Arg Ala Val Ile Ser Trp Trp Ser Ser Gly Thr Gly Gly Ala Gly 
            180                 185                 190         


Leu Leu Gly Ala Leu Ser Tyr Leu Gly Leu Thr Gln Ala Gly Leu Ser 
        195                 200                 205             


Pro Gln Gln Thr Leu Leu Ser Met Leu Gly Ile Pro Ala Leu Leu Leu 
    210                 215                 220                 


Ala Ser Tyr Phe Leu Leu Leu Thr Ser Pro Glu Ala Gln Asp Pro Gly 
225                 230                 235                 240 


Gly Glu Glu Glu Ala Glu Ser Ala Ala Arg Gln Pro Leu Ile Arg Thr 
                245                 250                 255     


Glu Ala Pro Glu Ser Lys Pro Gly Ser Ser Ser Ser Leu Ser Leu Arg 
            260                 265                 270         


Glu Arg Trp Thr Val Phe Lys Gly Leu Leu Trp Tyr Ile Val Pro Leu 
        275                 280                 285             


Val Val Val Tyr Phe Ala Glu Tyr Phe Ile Asn Gln Gly Leu Phe Glu 
    290                 295                 300                 


Leu Leu Phe Phe Trp Asn Thr Ser Leu Ser His Ala Gln Gln Tyr Arg 
305                 310                 315                 320 


Trp Tyr Gln Met Leu Tyr Gln Ala Gly Val Phe Ala Ser Arg Ser Ser 
                325                 330                 335     


Leu Arg Cys Cys Arg Ile Arg Phe Thr Trp Ala Leu Ala Leu Leu Gln 
            340                 345                 350         


Cys Leu Asn Leu Val Phe Leu Leu Ala Asp Val Trp Phe Gly Phe Leu 
        355                 360                 365             


Pro Ser Ile Tyr Leu Val Phe Leu Ile Ile Leu Tyr Glu Gly Leu Leu 
    370                 375                 380                 


Gly Gly Ala Ala Tyr Val Asn Thr Phe His Asn Ile Ala Leu Glu Thr 
385                 390                 395                 400 


Ser Asp Glu His Arg Glu Phe Ala Met Ala Ala Thr Cys Ile Ser Asp 
                405                 410                 415     


Thr Leu Gly Ile Ser Leu Ser Gly Leu Leu Ala Leu Pro Leu His Asp 
            420                 425                 430         


Phe Leu Cys Gln Leu Ser 
        435             


<210>  10
<211>  1689
<212>  DNA
<213>  homo sapiens

<400>  10
cccctagaca agccggagct gggaccggca atcgggcgtt gatccttgtc acctgtcgca       60

gaccctcatc cctcccgtgg gagccccctt tggacactct atgaccctgg accctcgggg      120

gacctgaact tgatgcgatg ggaggctgtg caggctcgcg gcggcgcttt tcggattccg      180

agggggagga gaccgtcccg gagccccggc tccctctgtt ggaccatcag ggcgcgcatt      240

ggaagaacgc ggtgggcttc tggctgctgg gcctttgcaa caacttctct tatgtggtga      300

tgctgagtgc cgcccacgac atccttagcc acaagaggac atcgggaaac cagagccatg      360

tggacccagg cccaacgccg atcccccaca acagctcatc acgatttgac tgcaactctg      420

tctctacggc tgctgtgctc ctggcggaca tcctccccac actcgtcatc aaattgttgg      480

ctcctcttgg ccttcacctg ctgccctaca gcccccgggt tctcgtcagt gggatttgtg      540

ctgctggaag cttcgtcctg gttgcctttt ctcattctgt ggggaccagc ctgtgtggtg      600

tggtcttcgc tagcatctca tcaggccttg gggaggtcac cttcctctcc ctcactgcct      660

tctaccccag ggccgtgatc tcctggtggt cctcagggac tgggggagct gggctgctgg      720

gggccctgtc ctacctgggc ctcacccagg ccggcctctc ccctcagcag accctgctgt      780

ccatgctggg tatccctgcc ctgctgctgg ccagctattt cttgttgctc acatctcctg      840

aggcccagga ccctggaggg gaagaagaag cagagagcgc agcccggcag cccctcataa      900

gaaccgaggc cccggagtcg aagccaggct ccagctccag cctctccctt cgggaaaggt      960

ggacagtatt caagggtctg ctgtggtaca ttgttccctt ggtcgtagtt tactttgccg     1020

agtatttcat taaccaggga ctttttgaac tcctcttttt ctggaacact tccctgagtc     1080

acgctcagca ataccgctgg taccagatgc tgtaccaggc tggcgtcttt gcctcccgct     1140

cttctctccg ctgctgtcgc atccgtttca cctgggccct ggccctgctg cagtgcctca     1200

acctggtgtt cctgctggca gacgtgtggt tcggctttct gccaagcatc tacctcgtct     1260

tcctgatcat tctgtatgag gggctcctgg gaggcgcagc ctacgtgaac accttccaca     1320

acatcgccct ggagaccagt gatgagcacc gggagtttgc aatggcggcc acctgcatct     1380

ctgacacact ggggatctcc ctgtcggggc tcctggcttt gcctctgcat gacttcctct     1440

gccagctctc ctgatactcg ggatcctcag gacgcaggtc acattcacct gtgggcagag     1500

ggacaggtca gacacccagg cccaccccag agaccctcca tgaactgtgc tcccagcctt     1560

cccggcaggt ctgggagtag ggaagggctg aagccttgtt tccttgcagg ggggccagcc     1620

attgtctccc acttggggag tttcttcctg gcatcatgcc ttctgaataa atgccgattt     1680

tgtccatgg                                                             1689


<210>  11
<211>  805
<212>  PRT
<213>  homo sapiens

<400>  11

Met Ala Asn Val Ser Lys Lys Val Ser Trp Ser Gly Arg Asp Arg Asp 
1               5                   10                  15      


Asp Glu Glu Ala Ala Pro Leu Leu Arg Arg Thr Ala Arg Pro Gly Gly 
            20                  25                  30          


Gly Thr Pro Leu Leu Asn Gly Ala Gly Pro Gly Ala Ala Arg Gln Ser 
        35                  40                  45              


Pro Arg Ser Ala Leu Phe Arg Val Gly His Met Ser Ser Val Glu Leu 
    50                  55                  60                  


Asp Asp Glu Leu Leu Asp Pro Asp Met Asp Pro Pro His Pro Phe Pro 
65                  70                  75                  80  


Lys Glu Ile Pro His Asn Glu Lys Leu Leu Ser Leu Lys Tyr Glu Ser 
                85                  90                  95      


Leu Asp Tyr Asp Asn Ser Glu Asn Gln Leu Phe Leu Glu Glu Glu Arg 
            100                 105                 110         


Arg Ile Asn His Thr Ala Phe Arg Thr Val Glu Ile Lys Arg Trp Val 
        115                 120                 125             


Ile Cys Ala Leu Ile Gly Ile Leu Thr Gly Leu Val Ala Cys Phe Ile 
    130                 135                 140                 


Asp Ile Val Val Glu Asn Leu Ala Gly Leu Lys Tyr Arg Val Ile Lys 
145                 150                 155                 160 


Gly Asn Ile Asp Lys Phe Thr Glu Lys Gly Gly Leu Ser Phe Ser Leu 
                165                 170                 175     


Leu Leu Trp Ala Thr Leu Asn Ala Ala Phe Val Leu Val Gly Ser Val 
            180                 185                 190         


Ile Val Ala Phe Ile Glu Pro Val Ala Ala Gly Ser Gly Ile Pro Gln 
        195                 200                 205             


Ile Lys Cys Phe Leu Asn Gly Val Lys Ile Pro His Val Val Arg Leu 
    210                 215                 220                 


Lys Thr Leu Val Ile Lys Val Ser Gly Val Ile Leu Ser Val Val Gly 
225                 230                 235                 240 


Gly Leu Ala Val Gly Lys Glu Gly Pro Met Ile His Ser Gly Ser Val 
                245                 250                 255     


Ile Ala Ala Gly Ile Ser Gln Gly Arg Ser Thr Ser Leu Lys Arg Asp 
            260                 265                 270         


Phe Lys Ile Phe Glu Tyr Phe Arg Arg Asp Thr Glu Lys Arg Asp Phe 
        275                 280                 285             


Val Ser Ala Gly Ala Ala Ala Gly Val Ser Ala Ala Phe Gly Ala Pro 
    290                 295                 300                 


Val Gly Gly Val Leu Phe Ser Leu Glu Glu Gly Ala Ser Phe Trp Asn 
305                 310                 315                 320 


Gln Phe Leu Thr Trp Arg Ile Phe Phe Ala Ser Met Ile Ser Thr Phe 
                325                 330                 335     


Thr Leu Asn Phe Val Leu Ser Ile Tyr His Gly Asn Met Trp Asp Leu 
            340                 345                 350         


Ser Ser Pro Gly Leu Ile Asn Phe Gly Arg Phe Asp Ser Glu Lys Met 
        355                 360                 365             


Ala Tyr Thr Ile His Glu Ile Pro Val Phe Ile Ala Met Gly Val Val 
    370                 375                 380                 


Gly Gly Val Leu Gly Ala Val Phe Asn Ala Leu Asn Tyr Trp Leu Thr 
385                 390                 395                 400 


Met Phe Arg Ile Arg Tyr Ile His Arg Pro Cys Leu Gln Val Ile Glu 
                405                 410                 415     


Ala Val Leu Val Ala Ala Val Thr Ala Thr Val Ala Phe Val Leu Ile 
            420                 425                 430         


Tyr Ser Ser Arg Asp Cys Gln Pro Leu Gln Gly Gly Ser Met Ser Tyr 
        435                 440                 445             


Pro Leu Gln Leu Phe Cys Ala Asp Gly Glu Tyr Asn Ser Met Ala Ala 
    450                 455                 460                 


Ala Phe Phe Asn Thr Pro Glu Lys Ser Val Val Ser Leu Phe His Asp 
465                 470                 475                 480 


Pro Pro Gly Ser Tyr Asn Pro Leu Thr Leu Gly Leu Phe Thr Leu Val 
                485                 490                 495     


Tyr Phe Phe Leu Ala Cys Trp Thr Tyr Gly Leu Thr Val Ser Ala Gly 
            500                 505                 510         


Val Phe Ile Pro Ser Leu Leu Ile Gly Ala Ala Trp Gly Arg Leu Phe 
        515                 520                 525             


Gly Ile Ser Leu Ser Tyr Leu Thr Gly Ala Ala Ile Trp Ala Asp Pro 
    530                 535                 540                 


Gly Lys Tyr Ala Leu Met Gly Ala Ala Ala Gln Leu Gly Gly Ile Val 
545                 550                 555                 560 


Arg Met Thr Leu Ser Leu Thr Val Ile Met Met Glu Ala Thr Ser Asn 
                565                 570                 575     


Val Thr Tyr Gly Phe Pro Ile Met Leu Val Leu Met Thr Ala Lys Ile 
            580                 585                 590         


Val Gly Asp Val Phe Ile Glu Gly Leu Tyr Asp Met His Ile Gln Leu 
        595                 600                 605             


Gln Ser Val Pro Phe Leu His Trp Glu Ala Pro Val Thr Ser His Ser 
    610                 615                 620                 


Leu Thr Ala Arg Glu Val Met Ser Thr Pro Val Thr Cys Leu Arg Arg 
625                 630                 635                 640 


Arg Glu Lys Val Gly Val Ile Val Asp Val Leu Ser Asp Thr Ala Ser 
                645                 650                 655     


Asn His Asn Gly Phe Pro Val Val Glu His Ala Asp Asp Thr Gln Pro 
            660                 665                 670         


Ala Arg Leu Gln Gly Leu Ile Leu Arg Ser Gln Leu Ile Val Leu Leu 
        675                 680                 685             


Lys His Lys Val Phe Val Glu Arg Ser Asn Leu Gly Leu Val Gln Arg 
    690                 695                 700                 


Arg Leu Arg Leu Lys Asp Phe Arg Asp Ala Tyr Pro Arg Phe Pro Pro 
705                 710                 715                 720 


Ile Gln Ser Ile His Val Ser Gln Asp Glu Arg Glu Cys Thr Met Asp 
                725                 730                 735     


Leu Ser Glu Phe Met Asn Pro Ser Pro Tyr Thr Val Pro Gln Glu Ala 
            740                 745                 750         


Ser Leu Pro Arg Val Phe Lys Leu Phe Arg Ala Leu Gly Leu Arg His 
        755                 760                 765             


Leu Val Val Val Asp Asn Arg Asn Gln Val Val Gly Leu Val Thr Arg 
    770                 775                 780                 


Lys Asp Leu Ala Arg Tyr Arg Leu Gly Lys Arg Gly Leu Glu Glu Leu 
785                 790                 795                 800 


Ser Leu Ala Gln Thr 
                805 


<210>  12
<211>  3277
<212>  DNA
<213>  homo sapiens

<400>  12
gccggcgctt cccggccggt gtcgctccgc ggcgggccat ggccaacgtc tctaagaagg       60

tgtcctggtc cggccgggac cgggacgacg aggaggcggc gccgctgctg cggaggacgg      120

cgcggcccgg cggggggacg ccgctgctga acggggctgg gcccggggct gcgcgccagt      180

caccacgttc tgcgcttttc cgagtcggac atatgagcag cgtggagctg gatgatgaac      240

ttttggaccc ggatatggac cctccacatc ccttccccaa ggagatccca cacaacgaga      300

agctcctgtc cctcaagtat gagagcttgg actatgacaa cagtgagaac cagctgttcc      360

tggaggagga gcggcggatc aatcacacgg ccttccggac ggtggagatc aagcgctggg      420

tcatctgcgc cctcattggg atcctcacgg gcctcgtggc ctgcttcatt gacatcgtgg      480

tggaaaacct ggctggcctc aagtacaggg tcatcaaggg caatatcgac aagttcacag      540

agaagggcgg actgtccttc tccctgttgc tgtgggccac gctgaacgcc gccttcgtgc      600

tcgtgggctc tgtgattgtg gctttcatag agccggtggc tgctggcagc ggaatccccc      660

agatcaagtg cttcctcaac ggggtgaaga tcccccacgt ggtgcggctc aagacgttgg      720

tgatcaaagt gtccggtgtg atcctgtccg tggtcggggg cctggccgtg ggaaaggaag      780

ggccgatgat ccactcaggt tcagtgattg ccgccgggat ctctcaggga aggtcaacgt      840

cactgaaacg agatttcaag atcttcgagt acttccgcag agacacagag aagcgggact      900

tcgtctccgc aggggctgcg gccggagtgt cagcggcgtt tggagccccc gtgggtgggg      960

tcctgttcag cttggaggag ggtgcgtcct tctggaacca gttcctgacc tggaggatct     1020

tctttgcttc catgatctcc acgttcaccc tgaattttgt tctgagcatt taccacggga     1080

acatgtggga cctgtccagc ccaggcctca tcaacttcgg aaggtttgac tcggagaaaa     1140

tggcctacac gatccacgag atcccggtct tcatcgccat gggcgtggtg ggcggtgtgc     1200

ttggagctgt gttcaatgcc ttgaactact ggctgaccat gtttcgaatc aggtacatcc     1260

accggccctg cctgcaggtg attgaggccg tgctggtggc cgccgtcacg gccacagttg     1320

ccttcgtgct gatctactcg tcgcgggatt gccagcccct gcaggggggc tccatgtcct     1380

acccgctgca gctcttttgt gcagatggcg agtacaactc catggctgcg gccttcttca     1440

acaccccgga gaagagcgtg gtgagcctct tccacgaccc gccaggctcc tacaaccccc     1500

tgaccctcgg cctgttcacg ctggtctact tcttcctggc ctgctggacc tacgggctca     1560

cggtgtctgc cggggtcttc atcccgtccc tgctcatcgg ggctgcctgg ggccggctct     1620

ttgggatctc cctgtcctac ctcacggggg cggcgatctg ggcggacccc ggcaaatacg     1680

ccctgatggg agctgctgcc cagctgggcg ggattgtgcg gatgacactg agcctgaccg     1740

tcatcatgat ggaggccacc agcaacgtga cctacggctt ccccatcatg ctggtgctca     1800

tgaccgccaa gatcgtgggc gacgtcttca ttgagggcct gtacgacatg cacattcagc     1860

tgcagagtgt gcccttcctg cactgggagg ccccggtcac ctcacactca ctcactgcca     1920

gggaggtgat gagcacacca gtgacctgcc tgaggcggcg tgagaaggtc ggcgtcattg     1980

tggacgtgct gagcgacacg gcgtccaatc acaacggctt ccccgtggtg gagcatgccg     2040

atgacaccca gcctgcccgg ctccagggcc tgatcctgcg ctcccagctc atcgttctcc     2100

taaagcacaa ggtgtttgtg gagcggtcca acctgggcct ggtacagcgg cgcctgaggc     2160

tgaaggactt ccgagacgcc tacccgcgct tcccacccat ccagtccatc cacgtgtccc     2220

aggacgagcg ggagtgcacc atggacctct ccgagttcat gaacccctcc ccctacacgg     2280

tgccccagga ggcgtcgctc ccacgggtgt tcaagctgtt ccgggccctg ggcctgcggc     2340

acctggtggt ggtggacaac cgcaatcagg ttgtcgggtt ggtgaccagg aaggacctcg     2400

ccaggtaccg cctgggaaag agaggcttgg aggagctctc gctggcccag acgtgaggcc     2460

cagccctgcc cataatgggc actggcgctg gcaccccggc ccttctgcat ttcctcccgg     2520

agtcactggt ttctcggccc aaaccatgct ccccagcagt ggcaatggcg agcaccctgc     2580

agctgggcgg gcaggcggca ggcgcggaac tgaccctctc gcgggactga ccctgttgtg     2640

ggcagtggtc tccccccttg gcgcctcctt gcgcaggccc agcctccact ctcctcgtct     2700

aggtttcttt acctccaggg atcagctgtg tgtgtgtgac ctccctaccg ggctatcggc     2760

ctcttgggag ccagcggcag ggccggcacc tgcgtgcctg tgcccgtgtg cgtgagacag     2820

agcccttgcc cctgctgctg ccccgagggc tgccctgccc tggaagggcc cctctgcctc     2880

cacaccagtg gagtcttcga gacttgggag ctgcttggcc tcattttcag ccatgagcag     2940

acggcctgtg gtccctgggc ctgaggcacg gactcgtagc accagggttt ggaggctgcg     3000

accgccccgg agagcagctt cacactggcg ccacagagga gccccacgtg cactccccgg     3060

cctgcatccg gcttgggtac acaggcccag aggactgggg tgactcacgg gccctgtgct     3120

gtgatgttga gagctgagaa aaacctccaa ggccctgagc cccatgccca gccctgcctt     3180

ggtcccccaa tccccagagc ttggagtctg ggccccacac ccagccctgc cttggtccct     3240

gagcctcaaa gcgtggaatt gctgccctgt ggacact                              3277


<210>  13
<211>  334
<212>  PRT
<213>  homo sapiens

<400>  13

Met Glu Pro Gly Pro Thr Ala Ala Gln Arg Arg Cys Ser Leu Pro Pro 
1               5                   10                  15      


Trp Leu Pro Leu Gly Leu Leu Leu Trp Ser Gly Leu Ala Leu Gly Ala 
            20                  25                  30          


Leu Pro Phe Gly Ser Ser Pro His Arg Val Phe His Asp Leu Leu Ser 
        35                  40                  45              


Glu Gln Gln Leu Leu Glu Val Glu Asp Leu Ser Leu Ser Leu Leu Gln 
    50                  55                  60                  


Gly Gly Gly Leu Gly Pro Leu Ser Leu Pro Pro Asp Leu Pro Asp Leu 
65                  70                  75                  80  


Asp Pro Glu Cys Arg Glu Leu Leu Leu Asp Phe Ala Asn Ser Ser Ala 
                85                  90                  95      


Glu Leu Thr Gly Cys Leu Val Arg Ser Ala Arg Pro Val Arg Leu Cys 
            100                 105                 110         


Gln Thr Cys Tyr Pro Leu Phe Gln Gln Val Val Ser Lys Met Asp Asn 
        115                 120                 125             


Ile Ser Arg Ala Ala Gly Asn Thr Ser Glu Ser Gln Ser Cys Ala Arg 
    130                 135                 140                 


Ser Leu Leu Met Ala Asp Arg Met Gln Ile Val Val Ile Leu Ser Glu 
145                 150                 155                 160 


Phe Phe Asn Thr Thr Trp Gln Glu Ala Asn Cys Ala Asn Cys Leu Thr 
                165                 170                 175     


Asn Asn Ser Glu Glu Leu Ser Asn Ser Thr Val Tyr Phe Leu Asn Leu 
            180                 185                 190         


Phe Asn His Thr Leu Thr Cys Phe Glu His Asn Leu Gln Gly Asn Ala 
        195                 200                 205             


His Ser Leu Leu Gln Thr Lys Asn Tyr Ser Glu Val Cys Lys Asn Cys 
    210                 215                 220                 


Arg Glu Ala Tyr Lys Thr Leu Ser Ser Leu Tyr Ser Glu Met Gln Lys 
225                 230                 235                 240 


Met Asn Glu Leu Glu Asn Lys Ala Glu Pro Gly Thr His Leu Cys Ile 
                245                 250                 255     


Asp Val Glu Asp Ala Met Asn Ile Thr Arg Lys Leu Trp Ser Arg Thr 
            260                 265                 270         


Phe Asn Cys Ser Val Pro Cys Ser Asp Thr Val Pro Val Ile Ala Val 
        275                 280                 285             


Ser Val Phe Ile Leu Phe Leu Pro Val Val Phe Tyr Leu Ser Ser Phe 
    290                 295                 300                 


Leu His Ser Glu Gln Lys Lys Arg Lys Leu Ile Leu Pro Lys Arg Leu 
305                 310                 315                 320 


Lys Ser Ser Thr Ser Phe Ala Asn Ile Gln Glu Asn Ser Asn 
                325                 330                 


<210>  14
<211>  2869
<212>  DNA
<213>  homo sapiens

<400>  14
ggctgtccgc ggtgccggct gggggcggag aggcggcggt gggctccctg gggtgtgtga       60

gcccggtgat ggagccgggc ccgacagccg cgcagcggag gtgttcgttg ccgccgtggc      120

tgccgctggg gctgctgctg tggtcggggc tggccctggg cgcgctcccc ttcggcagca      180

gtccgcacag ggtcttccac gacctcctgt cggagcagca gttgctggag gtggaggact      240

tgtccctgtc cctcctgcag ggtggagggc tggggcctct gtcgctgccc ccggacctgc      300

cggatctgga tcctgagtgc cgggagctcc tgctggactt cgccaacagc agcgcagagc      360

tgacagggtg tctggtgcgc agcgcccggc ccgtgcgcct ctgtcagacc tgctaccccc      420

tcttccaaca ggtcgtcagc aagatggaca acatcagccg agccgcgggg aatacttcag      480

agagtcagag ttgtgccaga agtctcttaa tggcagatag aatgcaaata gttgtgattc      540

tctcagaatt ttttaatacc acatggcagg aggcaaattg tgcaaattgt ttaacaaaca      600

acagtgaaga attatcaaac agcacagtat atttccttaa tctatttaat cacaccctga      660

cctgctttga acataacctt caggggaatg cacatagtct tttacagaca aaaaattatt      720

cagaagtatg caaaaactgc cgtgaagcat acaaaactct gagtagtctg tacagtgaaa      780

tgcaaaaaat gaatgaactt gagaataagg ctgaacctgg aacacattta tgcattgatg      840

tggaagatgc aatgaacatc actcgaaaac tatggagtcg aactttcaac tgttcagtcc      900

cttgcagtga cacagtgcct gtaattgctg tttctgtgtt cattctcttt ctacctgttg      960

tcttctacct tagtagcttt cttcactcag agcaaaagaa acgcaaactc attctgccca     1020

aacgtctcaa gtccagtacc agttttgcaa atattcagga aaattcaaac tgagacctac     1080

aaaatggaga attgacatat cacgtgaatg aatggtggaa gacacaactt ggtttcagaa     1140

agaagataaa ctgtgatttg acaagtcaag ctcttaagaa atacaaggac ttcagatcca     1200

tttttaaata agaattttcg atttttcttt ccttttccac ttctttctaa cagatttgga     1260

tatttttaat ttccaggcat agcagtgtta tctattttaa tgtgtatttg tcacaataac     1320

agaacatgca agaacaatca ttattttatt ttataggcat ttgattacta ttctagactt     1380

ctggtatctt cttactaaca taagtatctc aagtagaaaa gtttttgaaa actaacattt     1440

aaaaattaat cagttacagt aaagactttg aaaaagaaat gtacttgtta ggaagtagct     1500

taattacccc ccattgcagt attattgtta tatatatagt taatatgttg tacatcacaa     1560

taatatataa ttcagtctct agtttcccta gagtcatttt tgaaaccact gattgcaaac     1620

ctccctgaca atttttaaaa gtagtaagcc acattacatt tatctttgta aaaagattta     1680

tggtaactgg tttcttactt gacttttata aatagtattt tacatcttat ttttgccttt     1740

atttcataag taatttaaaa atcactggat tgctttatta tattcagggc aatatggatt     1800

atttttatac caaggatttg catcgtgaat taaattaagt tatttggcaa tttataattt     1860

attactactt taaatcaaat gtagcattat cacactgtat ttaaattgtc attttttaaa     1920

ggaatatttt cttcttaaga tatatagagg attttggaga agagagacag gaggggtaaa     1980

accagcttaa ggttcagcga gcagaaaggg acctgagagg atgctcactg taagactgtt     2040

ggacagtggt gtgtattgag gggatgaatc ggaacgatag tctcatgcag aaaatagtga     2100

gattaagatc atccttattg tttctaaatt atttcaatca gatgaaagtg atacgattga     2160

aatgaaatca catagttcgt gctcagaaat tctattttgg tatgtttgta ttagccttta     2220

gaaaaaacac tccgtttcag aattgttcac agttttattt cttaggtttt tagagttcag     2280

gatttcattt attaatttct tcttgctttt ttggtggaaa taggctttgt tgtaaacatt     2340

aagaatataa aatctcctct atatagaaac aagaattttg ttaaaaagag aatttgaatc     2400

ccttcctata ctataaaatg ctctataggg agacaaagtg tttctttttt cttttatgtt     2460

tactgtttat gtggagtgaa atataaggct cttggatgta taacatactc aaaagctgtt     2520

acactttctc tgatctgctg tgatccactg aaaatgtgct ggggtttgtt ctgctgtcac     2580

tgtttatgct gctggaactt agcactgtct tgatttgaag catatgattg agagccattt     2640

gaagcaatct tcattaatgc agataaaaca agtttacatg tgcagagtta gaaaatgaca     2700

tgttcaattc tgtaagtggt gactttttga gcacctttca gtattatgta tttgtaaaaa     2760

ccattgtttt tggatataaa gctaataagc actttaaaaa aaaaaaaaaa aaaaaaaaaa     2820

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagaaaaaa aaaaaaaaa                 2869


<210>  15
<211>  580
<212>  PRT
<213>  homo sapiens

<400>  15

Met Thr Ala Pro Ala Gly Pro Arg Gly Ser Glu Thr Glu Arg Leu Leu 
1               5                   10                  15      


Thr Pro Asn Pro Gly Tyr Gly Thr Gln Ala Gly Pro Ser Pro Ala Pro 
            20                  25                  30          


Pro Thr Pro Pro Glu Glu Glu Asp Leu Arg Arg Arg Leu Lys Tyr Phe 
        35                  40                  45              


Phe Met Ser Pro Cys Asp Lys Phe Arg Ala Lys Gly Arg Lys Pro Cys 
    50                  55                  60                  


Lys Leu Met Leu Gln Val Val Lys Ile Leu Val Val Thr Val Gln Leu 
65                  70                  75                  80  


Ile Leu Phe Gly Leu Ser Asn Gln Leu Ala Val Thr Phe Arg Glu Glu 
                85                  90                  95      


Asn Thr Ile Ala Phe Arg His Leu Phe Leu Leu Gly Tyr Ser Asp Gly 
            100                 105                 110         


Ala Asp Asp Thr Phe Ala Ala Tyr Thr Arg Glu Gln Leu Tyr Gln Ala 
        115                 120                 125             


Ile Phe His Ala Val Asp Gln Tyr Leu Ala Leu Pro Asp Val Ser Leu 
    130                 135                 140                 


Gly Arg Tyr Ala Tyr Val Arg Gly Gly Gly Asp Pro Trp Thr Asn Gly 
145                 150                 155                 160 


Ser Gly Leu Ala Leu Cys Gln Arg Tyr Tyr His Arg Gly His Val Asp 
                165                 170                 175     


Pro Ala Asn Asp Thr Phe Asp Ile Asp Pro Met Val Val Thr Asp Cys 
            180                 185                 190         


Ile Gln Val Asp Pro Pro Glu Arg Pro Pro Pro Pro Pro Ser Asp Asp 
        195                 200                 205             


Leu Thr Leu Leu Glu Ser Ser Ser Ser Tyr Lys Asn Leu Thr Leu Lys 
    210                 215                 220                 


Phe His Lys Leu Val Asn Val Thr Ile His Phe Arg Leu Lys Thr Ile 
225                 230                 235                 240 


Asn Leu Gln Ser Leu Ile Asn Asn Glu Ile Pro Asp Cys Tyr Thr Phe 
                245                 250                 255     


Ser Val Leu Ile Thr Phe Asp Asn Lys Ala His Ser Gly Arg Ile Pro 
            260                 265                 270         


Ile Ser Leu Glu Thr Gln Ala His Ile Gln Glu Cys Lys His Pro Ser 
        275                 280                 285             


Val Phe Gln His Gly Asp Asn Ser Phe Arg Leu Leu Phe Asp Val Val 
    290                 295                 300                 


Val Ile Leu Thr Cys Ser Leu Ser Phe Leu Leu Cys Ala Arg Ser Leu 
305                 310                 315                 320 


Leu Arg Gly Phe Leu Leu Gln Asn Glu Phe Val Gly Phe Met Trp Arg 
                325                 330                 335     


Gln Arg Gly Arg Val Ile Ser Leu Trp Glu Arg Leu Glu Phe Val Asn 
            340                 345                 350         


Gly Trp Tyr Ile Leu Leu Val Thr Ser Asp Val Leu Thr Ile Ser Gly 
        355                 360                 365             


Thr Ile Met Lys Ile Gly Ile Glu Ala Lys Asn Leu Ala Ser Tyr Asp 
    370                 375                 380                 


Val Cys Ser Ile Leu Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly 
385                 390                 395                 400 


Val Ile Arg Tyr Leu Thr Phe Phe His Asn Tyr Asn Ile Leu Ile Ala 
                405                 410                 415     


Thr Leu Arg Val Ala Leu Pro Ser Val Met Arg Phe Cys Cys Cys Val 
            420                 425                 430         


Ala Val Ile Tyr Leu Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly 
        435                 440                 445             


Pro Tyr His Val Lys Phe Arg Ser Leu Ser Met Val Ser Glu Cys Leu 
    450                 455                 460                 


Phe Ser Leu Ile Asn Gly Asp Asp Met Phe Val Thr Phe Ala Ala Met 
465                 470                 475                 480 


Gln Ala Gln Gln Gly Arg Ser Ser Leu Val Trp Leu Phe Ser Gln Leu 
                485                 490                 495     


Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr Met Val Leu Ser Leu 
            500                 505                 510         


Phe Ile Ala Leu Ile Thr Gly Ala Tyr Asp Thr Ile Lys His Pro Gly 
        515                 520                 525             


Gly Ala Gly Ala Glu Glu Ser Glu Leu Gln Ala Tyr Ile Ala Gln Cys 
    530                 535                 540                 


Gln Asp Ser Pro Thr Ser Gly Lys Phe Arg Arg Gly Ser Gly Ser Ala 
545                 550                 555                 560 


Cys Ser Leu Leu Cys Cys Cys Gly Arg Asp Pro Ser Glu Glu His Ser 
                565                 570                 575     


Leu Leu Val Asn 
            580 


<210>  16
<211>  2051
<212>  DNA
<213>  homo sapiens

<400>  16
agatcagctg atgccggagg gtttgaagcc gcgccgcgag ggagcgaggt cgcagtgaca       60

gcggcgggcg atcggaccca ggctgccccg ccgtacccgc ctgcgtcccg cgctcccgcc      120

ccagcatgac agccccggcg ggtccgcgcg gctcagagac cgagcggctt ctgaccccca      180

accccgggta tgggacccag gcggggcctt caccggcccc tccgacaccc ccagaagagg      240

aagaccttcg ccgtcgtctc aaatactttt tcatgagtcc ctgcgacaag tttcgagcca      300

agggccgcaa gccctgcaag ctgatgctgc aagtggtcaa gatcctggtg gtcacggtgc      360

agctcatcct gtttgggctc agtaatcagc tggctgtgac attccgggaa gagaacacca      420

tcgccttccg acacctcttc ctgctgggct actcggacgg agcggatgac accttcgcag      480

cctacacgcg ggagcagctg taccaggcca tcttccatgc tgtggaccag tacctggcgt      540

tgcctgacgt gtcactgggc cggtatgcgt atgtccgtgg tgggggtgac ccttggacca      600

atggctcagg gcttgctctc tgccagcggt actaccaccg aggccacgtg gacccggcca      660

acgacacatt tgacattgat ccgatggtgg ttactgactg catccaggtg gatccccccg      720

agcggccccc tccgcccccc agcgacgatc tcaccctctt ggaaagcagc tccagttaca      780

agaacctcac gctcaaattc cacaagctgg tcaatgtcac catccacttc cggctgaaga      840

ccattaacct ccagagcctc atcaataatg agatcccgga ctgctatacc ttcagcgtcc      900

tgatcacgtt tgacaacaaa gcacacagtg ggcggatccc catcagcctg gagacccagg      960

cccacatcca ggagtgtaag caccccagtg tcttccagca cggagacaac agcttccggc     1020

tcctgtttga cgtggtggtc atcctcacct gctccctgtc cttcctcctc tgcgcccgct     1080

cactccttcg aggcttcctg ctgcagaacg agtttgtggg gttcatgtgg cggcagcggg     1140

gacgggtcat cagcctgtgg gagcggctgg aatttgtcaa tggctggtac atcctgctcg     1200

tcaccagcga tgtgctcacc atctcgggca ccatcatgaa gatcggcatc gaggccaaga     1260

acttggcgag ctacgacgtc tgcagcatcc tcctgggcac ctcgacgctg ctggtgtggg     1320

tgggcgtgat ccgctacctg accttcttcc acaactacaa tatcctcatc gccacactgc     1380

gggtggccct gcccagcgtc atgcgcttct gctgctgcgt ggctgtcatc tacctgggct     1440

actgcttctg tggctggatc gtgctggggc cctatcatgt gaagttccgc tcactctcca     1500

tggtgtctga gtgcctgttc tcgctcatca atggggacga catgtttgtg acgttcgccg     1560

ccatgcaggc gcagcagggc cgcagcagcc tggtgtggct cttctcccag ctctaccttt     1620

actccttcat cagcctcttc atctacatgg tgctcagcct cttcatcgcg ctcatcaccg     1680

gcgcctacga caccatcaag catcccggcg gcgcaggcgc agaggagagc gagctgcagg     1740

cctacatcgc acagtgccag gacagcccca cctccggcaa gttccgccgc gggagcggct     1800

cggcctgcag ccttctctgc tgctgcggaa gggacccctc ggaggagcat tcgctgctgg     1860

tgaattgatt cgacctgact gccgttggac cgtaggccct ggactgcaga gacccccgcc     1920

cccgaccccg cttatttatt tgtagggttt gcttttaagg atcggctccc tgtcgcgccc     1980

gaggagggcc tggacctttc gtgtcggacc cttgggggcg gggagactgg gtggggaggg     2040

tgttgaataa a                                                          2051


<210>  17
<211>  663
<212>  PRT
<213>  homo sapiens

<400>  17

Met Thr Gly Ala Arg Ala Ser Ala Ala Glu Gln Arg Arg Ala Gly Arg 
1               5                   10                  15      


Ser Gly Gln Ala Arg Ala Ala Glu Arg Ala Ala Gly Met Ser Gly Ala 
            20                  25                  30          


Gly Arg Ala Leu Ala Ala Leu Leu Leu Ala Ala Ser Val Leu Ser Ala 
        35                  40                  45              


Ala Leu Leu Ala Pro Gly Gly Ser Ser Gly Arg Asp Ala Gln Ala Ala 
    50                  55                  60                  


Pro Pro Arg Asp Leu Asp Lys Lys Arg His Ala Glu Leu Lys Met Asp 
65                  70                  75                  80  


Gln Ala Leu Leu Leu Ile His Asn Glu Leu Leu Trp Thr Asn Leu Thr 
                85                  90                  95      


Val Tyr Trp Lys Ser Glu Cys Cys Tyr His Cys Leu Phe Gln Val Leu 
            100                 105                 110         


Val Asn Val Pro Gln Ser Pro Lys Ala Gly Lys Pro Ser Ala Ala Ala 
        115                 120                 125             


Ala Ser Val Ser Thr Gln His Gly Ser Ile Leu Gln Leu Asn Asp Thr 
    130                 135                 140                 


Leu Glu Glu Lys Glu Val Cys Arg Leu Glu Tyr Arg Phe Gly Glu Phe 
145                 150                 155                 160 


Gly Asn Tyr Ser Leu Leu Val Lys Asn Ile His Asn Gly Val Ser Glu 
                165                 170                 175     


Ile Ala Cys Asp Leu Ala Val Asn Glu Asp Pro Val Asp Ser Asn Leu 
            180                 185                 190         


Pro Val Ser Ile Ala Phe Leu Ile Gly Leu Ala Val Ile Ile Val Ile 
        195                 200                 205             


Ser Phe Leu Arg Leu Leu Leu Ser Leu Asp Asp Phe Asn Asn Trp Ile 
    210                 215                 220                 


Ser Lys Ala Ile Ser Ser Arg Glu Thr Asp Arg Leu Ile Asn Ser Glu 
225                 230                 235                 240 


Leu Gly Ser Pro Ser Arg Thr Asp Pro Leu Asp Gly Asp Val Gln Pro 
                245                 250                 255     


Ala Thr Trp Arg Leu Ser Ala Leu Pro Pro Arg Leu Arg Ser Val Asp 
            260                 265                 270         


Thr Phe Arg Gly Ile Ala Leu Ile Leu Met Val Phe Val Asn Tyr Gly 
        275                 280                 285             


Gly Gly Lys Tyr Trp Tyr Phe Lys His Ala Ser Trp Asn Gly Leu Thr 
    290                 295                 300                 


Val Ala Asp Leu Val Phe Pro Trp Phe Val Phe Ile Met Gly Ser Ser 
305                 310                 315                 320 


Ile Phe Leu Ser Met Thr Ser Ile Leu Gln Arg Gly Cys Ser Lys Phe 
                325                 330                 335     


Arg Leu Leu Gly Lys Ile Ala Trp Arg Ser Phe Leu Leu Ile Cys Ile 
            340                 345                 350         


Gly Ile Ile Ile Val Asn Pro Asn Tyr Cys Leu Gly Pro Leu Ser Trp 
        355                 360                 365             


Asp Lys Val Arg Ile Pro Gly Val Leu Gln Arg Leu Gly Val Thr Tyr 
    370                 375                 380                 


Phe Val Val Ala Val Leu Glu Leu Leu Phe Ala Lys Pro Val Pro Glu 
385                 390                 395                 400 


His Cys Ala Ser Glu Arg Ser Cys Leu Ser Leu Arg Asp Ile Thr Ser 
                405                 410                 415     


Ser Trp Pro Gln Trp Leu Leu Ile Leu Val Leu Glu Gly Leu Trp Leu 
            420                 425                 430         


Gly Leu Thr Phe Leu Leu Pro Val Pro Gly Cys Pro Thr Gly Tyr Leu 
        435                 440                 445             


Gly Pro Gly Gly Ile Gly Asp Phe Gly Lys Tyr Pro Asn Cys Thr Gly 
    450                 455                 460                 


Gly Ala Ala Gly Tyr Ile Asp Arg Leu Leu Leu Gly Asp Asp His Leu 
465                 470                 475                 480 


Tyr Gln His Pro Ser Ser Ala Val Leu Tyr His Thr Glu Val Ala Tyr 
                485                 490                 495     


Asp Pro Glu Gly Ile Leu Gly Thr Ile Asn Ser Ile Val Met Ala Phe 
            500                 505                 510         


Leu Gly Val Gln Ala Gly Lys Ile Leu Leu Tyr Tyr Lys Ala Arg Thr 
        515                 520                 525             


Lys Asp Ile Leu Ile Arg Phe Thr Ala Trp Cys Cys Ile Leu Gly Leu 
    530                 535                 540                 


Ile Ser Val Ala Leu Thr Lys Val Ser Glu Asn Glu Gly Phe Ile Pro 
545                 550                 555                 560 


Val Asn Lys Asn Leu Trp Ser Leu Ser Tyr Val Thr Thr Leu Ser Ser 
                565                 570                 575     


Phe Ala Phe Phe Ile Leu Leu Val Leu Tyr Pro Val Val Asp Val Lys 
            580                 585                 590         


Gly Leu Trp Thr Gly Thr Pro Phe Phe Tyr Pro Gly Met Asn Ser Ile 
        595                 600                 605             


Leu Val Tyr Val Gly His Glu Val Phe Glu Asn Tyr Phe Pro Phe Gln 
    610                 615                 620                 


Trp Lys Leu Lys Asp Asn Gln Ser His Lys Glu His Leu Thr Gln Asn 
625                 630                 635                 640 


Ile Val Ala Thr Ala Leu Trp Val Leu Ile Ala Tyr Ile Leu Tyr Arg 
                645                 650                 655     


Lys Lys Ile Phe Trp Lys Ile 
            660             


<210>  18
<211>  5228
<212>  DNA
<213>  homo sapiens

<400>  18
agggcggggc gcagcgggca ggcaagggcg gccgagcggg cggcgggcat gagcggggcg       60

ggcagggcgc tggccgcgct gctgctggcc gcgtccgtgc tgagcgccgc gctgctggcc      120

cccggcggct cttcggggcg cgatgcccag gccgcgccgc cacgagactt agacaaaaaa      180

agacatgcag agctgaagat ggatcaggct ttgctactca tccataatga acttctctgg      240

accaacttga ccgtctactg gaaatctgaa tgctgttatc actgcttgtt tcaggttctg      300

gtaaacgttc ctcagagtcc aaaagcaggg aagcctagtg ctgcagctgc ctctgtcagc      360

acccagcacg gatctatcct gcagctgaac gacaccttgg aagagaaaga agtttgtagg      420

ttggaataca gatttggaga atttggaaac tattctctct tggtaaagaa catccataat      480

ggagttagtg aaattgcctg tgacctggct gtgaacgagg atccagttga tagtaacctt      540

cctgtgagca ttgcattcct tattggtctt gctgtcatca ttgtgatatc ctttctgagg      600

ctcttgttga gtttggatga ctttaacaat tggatttcta aagccataag ttctcgagaa      660

actgatcgcc tcatcaattc tgagctggga tctcccagca ggacagaccc tctcgatggt      720

gatgttcagc cagcaacgtg gcgtctatct gccctgccgc cccgcctccg cagcgtggac      780

accttcaggg ggattgctct tatactcatg gtctttgtca attatggagg aggaaaatat      840

tggtacttca aacatgcaag ttggaatggg ctgacagtgg ctgacctcgt gttcccgtgg      900

tttgtattta ttatgggatc ttccattttt ctatcgatga cttctatact gcaacggggg      960

tgttcaaaat tcagattgct ggggaagatt gcatggagga gtttcctgtt aatctgcata     1020

ggaattatca ttgtgaatcc caattattgc cttggtccat tgtcttggga caaggtgcgc     1080

attcctggtg tgctgcagcg attgggagtg acatactttg tggttgctgt gttggagctc     1140

ctctttgcta aacctgtgcc tgaacattgt gcctcggaga ggagctgcct ttctcttcga     1200

gacatcacgt ccagctggcc ccagtggctg ctcatcctgg tgctggaagg cctgtggctg     1260

ggcttgacat tcctcctgcc agtccctggg tgccctactg gttatcttgg tcctgggggc     1320

attggagatt ttggcaagta tccaaattgc actggaggag ctgcaggcta catcgaccgc     1380

ctgctgctgg gagacgatca cctttaccag cacccatctt ctgctgtact ttaccacacc     1440

gaggtggcct atgaccccga gggcatcctg ggcaccatca actccatcgt gatggccttt     1500

ttaggagttc aggcaggaaa aatactattg tattacaagg ctcggaccaa agacatcctg     1560

attcgattca ctgcttggtg ttgtattctt gggctcattt ctgttgctct gacgaaggtt     1620

tctgaaaatg aaggctttat tccagtaaac aaaaatctct ggtccctttc gtatgtcact     1680

acgctcagtt cttttgcctt cttcatcctg ctggtcctgt acccagttgt ggatgtgaag     1740

gggctgtgga caggaacccc attcttttat ccaggaatga attccattct ggtatatgtc     1800

ggccacgagg tgtttgagaa ctacttcccc tttcagtgga agctgaagga caaccagtcc     1860

cacaaggagc acctgactca gaacatcgtc gccactgccc tctgggtgct cattgcctac     1920

atcctctata gaaagaagat tttttggaaa atctgatggc tcccactgag atgtgctgct     1980

ggaagactct agtaggcctg cagggaggac tgaagcagcc tttgttaaag ggaagcattc     2040

attaggaaat tgactggctg cgtgtttaca gactctgggg gaagacactg atgtcctcaa     2100

actggttaac tgtgacacgg ctcgccagaa ctctgcctgt ctatttgtga cttacagatt     2160

tgaaatgtaa ttgtcttttt tcctccatct tctgtggaaa tggatgtctt tggaacttca     2220

ttccgaggag ataagcttta actttccaaa agggaattgc catgggtgtt tttcttctgt     2280

ggtgagtgaa acaatctgag gtctggttct tgctgacctt gttgccctgc aaacttcctt     2340

tccacgtgta cgcgcacacc aacacgaaat gccatcactc ctactgcggc tgctatgaag     2400

cttactggtt gtgatgtgtt ataatttagt ctgttttttt gattgaatgc agtttaatgt     2460

ttccagaaag ccaaagtaat tttcttttca gatatgcaag gctttggtgg gtccaaaaaa     2520

tgtctatcac aagccatttt ttccttttcc tctctcgaaa agttaaaata tctatgtgtt     2580

attcccaaac cctcttacct atgtatctgc ctgtctgtcc atcatcttcc ttcctcccta     2640

tctctgtgta tctggatggc agccgctgcc caggggagtg gctgtgggga gggcaggtac     2700

tgtctttgcc tgtgggtcca gctgagccat ccctgctggg tgatgctggg caagaccctt     2760

ggcccgtctg ggccttggct tcctcacttg tgaaatgagc gggaagatga ctctcagttc     2820

cttccacctc ttagacatgg tgaggtaaca gacatcaaaa gcttttctga aatcttcaga     2880

agaaatagtt ccattacaga aaactcttca aaataaatag tagtgaaaac ttttaaaaac     2940

tctcattgga gtaagtcttt tcaagatgat cctccacaat ggaggcagcg ttcctacttg     3000

tcatcacaca gctgaagaca ttgtttctta ggtgtgaaat cggggacaaa ggacaaacag     3060

agacacacgg cattgttcat gggaggcatc gtcaccctcc tgggtgttct gtgggaattt     3120

cctgtgtgag gaaaacgtgg ccacagggtt gtgctgtacc cacccttccc cggcgagatg     3180

gccctcggcc tgtgccgctg cttccaccct cgccactcca tggcagcttt tggtctgttt     3240

ccggctctgc cctctgccct gaactctcat ccggcttgta cctgcctgct ggacccctcc     3300

acctggaggc cagcccatgt ctcaggccca gccctagcct cttctcctca aattctaagt     3360

gttttctctt taggtttccc tggctttgtg aatggatcat gtgtctctag gtataaacct     3420

gacatcatct ttccacccgg cttacctcca ccagatctcc ccagttctgt ctccatcttc     3480

tacctgcagc tgctctgttc tcatggtcac tgctgcatca ctgagtctgg acccttgtta     3540

tcattttcaa actggcctcc ttccctcgtt ccccacttct taaagtcacc tgtccattgc     3600

caccagatta agctttctcc agccagatca cctctctctg agaaacctcc attgacatgg     3660

aaacaccatt gtctggcaca catactcaca tactcacctt cccgtcttga tccccacaca     3720

tctttccagc ctcccctccc actccactcc ctgctctctc ctccacctcc ccatcctctt     3780

gtctcccctc ccctctgaat ccagcccagc ggggcttctc ctgcctccat cacatcacag     3840

aagtacctcc tgcttctggt tttaattaga gccttccccg attacatttt cctctgaatt     3900

ttttcctatc tacatttgat ctgtcatgtt taaaccccct acttctaagg gaacttctct     3960

aatctcttat cctcatcccc aaatagtgtt ttcttcctct gggttcttat aatgttggta     4020

tcaatctcac agcatttagt gcttcctgcc tggtgtgaca gttacctgtg tgcatgtgca     4080

atttctaatt tcccacgcta gactgtgagc ttcctaaggc aagaatcatg ccttgttggt     4140

ttctgtattc ctcatggtgc caaacacagt gccttctaca ttgcaggcgc tgaataaaca     4200

tttttaaagc aaaatgatgt ggatttttaa aataaatatt taagtgctgg taagatgagc     4260

atgtatccgg ggtgcccatg aaatgttctt ggggccgtgt ggggacagtc gtcattcctc     4320

ctcctgccac ccttttcttt cagtgagtca ctgtggatgg tcccagctgt gtcatcccaa     4380

agttcagcag ggaaagctga gctgggcctc tccaggtgag ttttctagaa gcatttctca     4440

aactgtgggt tacatcaact tgggtgtctt gagctgtaag gaaggaactc cggagtcagc     4500

tgggctacag gggagcttct ctaagtcctg cgggaggcca gacccagcct gagcttgctg     4560

ttagctagcg gaggcagctg ctggtggccc aggtgctcga caccaggcat cccctctcct     4620

cccacgaagg gtgtgccata atccccttca acaggaaatg cttcccagaa gcctctcagc     4680

agcctcccct cctgtcctat cagctagaag cgcctcgctt gtcccaagac cagcagggac     4740

agggaactgt ccgagcccgt ggctgtgtgg aggaaggcga cccccagcac aagattggtt     4800

tcctttggga agggaagagg gagtgtgttg gggtaagggg tagagcagag gaatggtcag     4860

ggggcaacaa ccgctgacag ctgcaacagg tgcatggcat ctcacaggga ggcagggagg     4920

tgcgagctcc taagtaatgg agcaaaaaaa ttctattctg tagaatgggg agagaaaatg     4980

tgacatttta attttttttt gcatttatat tcctaattcc tacttaaagt gaatatactg     5040

ccgctgtaga tcataaaatg tatcttttcc atggccaaca aggggcatct tttataaatg     5100

cataataacc cagtttgtat caaagggtat cgacttaagt gaaatttcaa catgctgtta     5160

ctttttcctt ttaatgtaat tctgttttcc aaataaatgg gggagacaaa tggaaaaaaa     5220

aaaaaaaa                                                              5228


<210>  19
<211>  1278
<212>  PRT
<213>  homo sapiens

<400>  19

Met Thr Ala Arg Gly Leu Ala Leu Gly Leu Leu Leu Leu Leu Leu Cys 
1               5                   10                  15      


Pro Ala Gln Val Phe Ser Gln Ser Cys Val Trp Tyr Gly Glu Cys Gly 
            20                  25                  30          


Ile Ala Tyr Gly Asp Lys Arg Tyr Asn Cys Glu Tyr Ser Gly Pro Pro 
        35                  40                  45              


Lys Pro Leu Pro Lys Asp Gly Tyr Asp Leu Val Gln Glu Leu Cys Pro 
    50                  55                  60                  


Gly Phe Phe Phe Gly Asn Val Ser Leu Cys Cys Asp Val Arg Gln Leu 
65                  70                  75                  80  


Gln Thr Leu Lys Asp Asn Leu Gln Leu Pro Leu Gln Phe Leu Ser Arg 
                85                  90                  95      


Cys Pro Ser Cys Phe Tyr Asn Leu Leu Asn Leu Phe Cys Glu Leu Thr 
            100                 105                 110         


Cys Ser Pro Arg Gln Ser Gln Phe Leu Asn Val Thr Ala Thr Glu Asp 
        115                 120                 125             


Tyr Val Asp Pro Val Thr Asn Gln Thr Lys Thr Asn Val Lys Glu Leu 
    130                 135                 140                 


Gln Tyr Tyr Val Gly Gln Ser Phe Ala Asn Ala Met Tyr Asn Ala Cys 
145                 150                 155                 160 


Arg Asp Val Glu Ala Pro Ser Ser Asn Asp Lys Ala Leu Gly Leu Leu 
                165                 170                 175     


Cys Gly Lys Asp Ala Asp Ala Cys Asn Ala Thr Asn Trp Ile Glu Tyr 
            180                 185                 190         


Met Phe Asn Lys Asp Asn Gly Gln Ala Pro Phe Thr Ile Thr Pro Val 
        195                 200                 205             


Phe Ser Asp Phe Pro Val His Gly Met Glu Pro Met Asn Asn Ala Thr 
    210                 215                 220                 


Lys Gly Cys Asp Glu Ser Val Asp Glu Val Thr Ala Pro Cys Ser Cys 
225                 230                 235                 240 


Gln Asp Cys Ser Ile Val Cys Gly Pro Lys Pro Gln Pro Pro Pro Pro 
                245                 250                 255     


Pro Ala Pro Trp Thr Ile Leu Gly Leu Asp Ala Met Tyr Val Ile Met 
            260                 265                 270         


Trp Ile Thr Tyr Met Ala Phe Leu Leu Val Phe Phe Gly Ala Phe Phe 
        275                 280                 285             


Ala Val Trp Cys Tyr Arg Lys Arg Tyr Phe Val Ser Glu Tyr Thr Pro 
    290                 295                 300                 


Ile Asp Ser Asn Ile Ala Phe Ser Val Asn Ala Ser Asp Lys Gly Glu 
305                 310                 315                 320 


Ala Ser Cys Cys Asp Pro Val Ser Ala Ala Phe Glu Gly Cys Leu Arg 
                325                 330                 335     


Arg Leu Phe Thr Arg Trp Gly Ser Phe Cys Val Arg Asn Pro Gly Cys 
            340                 345                 350         


Val Ile Phe Phe Ser Leu Val Phe Ile Thr Ala Cys Ser Ser Gly Leu 
        355                 360                 365             


Val Phe Val Arg Val Thr Thr Asn Pro Val Asp Leu Trp Ser Ala Pro 
    370                 375                 380                 


Ser Ser Gln Ala Arg Leu Glu Lys Glu Tyr Phe Asp Gln His Phe Gly 
385                 390                 395                 400 


Pro Phe Phe Arg Thr Glu Gln Leu Ile Ile Arg Ala Pro Leu Thr Asp 
                405                 410                 415     


Lys His Ile Tyr Gln Pro Tyr Pro Ser Gly Ala Asp Val Pro Phe Gly 
            420                 425                 430         


Pro Pro Leu Asp Ile Gln Ile Leu His Gln Val Leu Asp Leu Gln Ile 
        435                 440                 445             


Ala Ile Glu Asn Ile Thr Ala Ser Tyr Asp Asn Glu Thr Val Thr Leu 
    450                 455                 460                 


Gln Asp Ile Cys Leu Ala Pro Leu Ser Pro Tyr Asn Thr Asn Cys Thr 
465                 470                 475                 480 


Ile Leu Ser Val Leu Asn Tyr Phe Gln Asn Ser His Ser Val Leu Asp 
                485                 490                 495     


His Lys Lys Gly Asp Asp Phe Phe Val Tyr Ala Asp Tyr His Thr His 
            500                 505                 510         


Phe Leu Tyr Cys Val Arg Ala Pro Ala Ser Leu Asn Asp Thr Ser Leu 
        515                 520                 525             


Leu His Asp Pro Cys Leu Gly Thr Phe Gly Gly Pro Val Phe Pro Trp 
    530                 535                 540                 


Leu Val Leu Gly Gly Tyr Asp Asp Gln Asn Tyr Asn Asn Ala Thr Ala 
545                 550                 555                 560 


Leu Val Ile Thr Phe Pro Val Asn Asn Tyr Tyr Asn Asp Thr Glu Lys 
                565                 570                 575     


Leu Gln Arg Ala Gln Ala Trp Glu Lys Glu Phe Ile Asn Phe Val Lys 
            580                 585                 590         


Asn Tyr Lys Asn Pro Asn Leu Thr Ile Ser Phe Thr Ala Glu Arg Ser 
        595                 600                 605             


Ile Glu Asp Glu Leu Asn Arg Glu Ser Asp Ser Asp Val Phe Thr Val 
    610                 615                 620                 


Val Ile Ser Tyr Ala Ile Met Phe Leu Tyr Ile Ser Leu Ala Leu Gly 
625                 630                 635                 640 


His Ile Lys Ser Cys Arg Arg Leu Leu Val Asp Ser Lys Val Ser Leu 
                645                 650                 655     


Gly Ile Ala Gly Ile Leu Ile Val Leu Ser Ser Val Ala Cys Ser Leu 
            660                 665                 670         


Gly Val Phe Ser Tyr Ile Gly Leu Pro Leu Thr Leu Ile Val Ile Glu 
        675                 680                 685             


Val Ile Pro Phe Leu Val Leu Ala Val Gly Val Asp Asn Ile Phe Ile 
    690                 695                 700                 


Leu Val Gln Ala Tyr Gln Arg Asp Glu Arg Leu Gln Gly Glu Thr Leu 
705                 710                 715                 720 


Asp Gln Gln Leu Gly Arg Val Leu Gly Glu Val Ala Pro Ser Met Phe 
                725                 730                 735     


Leu Ser Ser Phe Ser Glu Thr Val Ala Phe Phe Leu Gly Ala Leu Ser 
            740                 745                 750         


Val Met Pro Ala Val His Thr Phe Ser Leu Phe Ala Gly Leu Ala Val 
        755                 760                 765             


Phe Ile Asp Phe Leu Leu Gln Ile Thr Cys Phe Val Ser Leu Leu Gly 
    770                 775                 780                 


Leu Asp Ile Lys Arg Gln Glu Lys Asn Arg Leu Asp Ile Phe Cys Cys 
785                 790                 795                 800 


Val Arg Gly Ala Glu Asp Gly Thr Ser Val Gln Ala Ser Glu Ser Cys 
                805                 810                 815     


Leu Phe Arg Phe Phe Lys Asn Ser Tyr Ser Pro Leu Leu Leu Lys Asp 
            820                 825                 830         


Trp Met Arg Pro Ile Val Ile Ala Ile Phe Val Gly Val Leu Ser Phe 
        835                 840                 845             


Ser Ile Ala Val Leu Asn Lys Val Asp Ile Gly Leu Asp Gln Ser Leu 
    850                 855                 860                 


Ser Met Pro Asp Asp Ser Tyr Met Val Asp Tyr Phe Lys Ser Ile Ser 
865                 870                 875                 880 


Gln Tyr Leu His Ala Gly Pro Pro Val Tyr Phe Val Leu Glu Glu Gly 
                885                 890                 895     


His Asp Tyr Thr Ser Ser Lys Gly Gln Asn Met Val Cys Gly Gly Met 
            900                 905                 910         


Gly Cys Asn Asn Asp Ser Leu Val Gln Gln Ile Phe Asn Ala Ala Gln 
        915                 920                 925             


Leu Asp Asn Tyr Thr Arg Ile Gly Phe Ala Pro Ser Ser Trp Ile Asp 
    930                 935                 940                 


Asp Tyr Phe Asp Trp Val Lys Pro Gln Ser Ser Cys Cys Arg Val Asp 
945                 950                 955                 960 


Asn Ile Thr Asp Gln Phe Cys Asn Ala Ser Val Val Asp Pro Ala Cys 
                965                 970                 975     


Val Arg Cys Arg Pro Leu Thr Pro Glu Gly Lys Gln Arg Pro Gln Gly 
            980                 985                 990         


Gly Asp Phe Met Arg Phe Leu Pro  Met Phe Leu Ser Asp  Asn Pro Asn 
        995                 1000                 1005             


Pro Lys  Cys Gly Lys Gly Gly  His Ala Ala Tyr Ser  Ser Ala Val 
    1010                 1015                 1020             


Asn Ile  Leu Leu Gly His Gly  Thr Arg Val Gly Ala  Thr Tyr Phe 
    1025                 1030                 1035             


Met Thr  Tyr His Thr Val Leu  Gln Thr Ser Ala Asp  Phe Ile Asp 
    1040                 1045                 1050             


Ala Leu  Lys Lys Ala Arg Leu  Ile Ala Ser Asn Val  Thr Glu Thr 
    1055                 1060                 1065             


Met Gly  Ile Asn Gly Ser Ala  Tyr Arg Val Phe Pro  Tyr Ser Val 
    1070                 1075                 1080             


Phe Tyr  Val Phe Tyr Glu Gln  Tyr Leu Thr Ile Ile  Asp Asp Thr 
    1085                 1090                 1095             


Ile Phe  Asn Leu Gly Val Ser  Leu Gly Ala Ile Phe  Leu Val Thr 
    1100                 1105                 1110             


Met Val  Leu Leu Gly Cys Glu  Leu Trp Ser Ala Val  Ile Met Cys 
    1115                 1120                 1125             


Ala Thr  Ile Ala Met Val Leu  Val Asn Met Phe Gly  Val Met Trp 
    1130                 1135                 1140             


Leu Trp  Gly Ile Ser Leu Asn  Ala Val Ser Leu Val  Asn Leu Val 
    1145                 1150                 1155             


Met Ser  Cys Gly Ile Ser Val  Glu Phe Cys Ser His  Ile Thr Arg 
    1160                 1165                 1170             


Ala Phe  Thr Val Ser Met Lys  Gly Ser Arg Val Glu  Arg Ala Glu 
    1175                 1180                 1185             


Glu Ala  Leu Ala His Met Gly  Ser Ser Val Phe Ser  Gly Ile Thr 
    1190                 1195                 1200             


Leu Thr  Lys Phe Gly Gly Ile  Val Val Leu Ala Phe  Ala Lys Ser 
    1205                 1210                 1215             


Gln Ile  Phe Gln Ile Phe Tyr  Phe Arg Met Tyr Leu  Ala Met Val 
    1220                 1225                 1230             


Leu Leu  Gly Ala Thr His Gly  Leu Ile Phe Leu Pro  Val Leu Leu 
    1235                 1240                 1245             


Ser Tyr  Ile Gly Pro Ser Val  Asn Lys Ala Lys Ser  Cys Ala Thr 
    1250                 1255                 1260             


Glu Glu  Arg Tyr Lys Gly Thr  Glu Arg Glu Arg Leu  Leu Asn Phe 
    1265                 1270                 1275             


<210>  20
<211>  4673
<212>  DNA
<213>  homo sapiens

<400>  20
tttgctcctg ctcctccgct cctcctgcgc ggggtgctga aacagcccgg ggaagtagag       60

ccgcctccgg ggagcccaac cagccgaacg ccgccggcgt cagcagcctt gcgcggccac      120

agcatgaccg ctcgcggcct ggcccttggc ctcctcctgc tgctactgtg tccagcgcag      180

gtgttttcac agtcctgtgt ttggtatgga gagtgtggaa ttgcatatgg ggacaagagg      240

tacaattgcg aatattctgg cccaccaaaa ccattgccaa aggatggata tgacttagtg      300

caggaactct gtccaggatt cttctttggc aatgtcagtc tctgttgtga tgttcggcag      360

cttcagacac taaaagacaa cctgcagctg cctctacagt ttctgtccag atgtccatcc      420

tgtttttata acctactgaa cctgttttgt gagctgacat gtagccctcg acagagtcag      480

tttttgaatg ttacagctac tgaagattat gttgatcctg ttacaaacca gacgaaaaca      540

aatgtgaaag agttacaata ctacgtcgga cagagttttg ccaatgcaat gtacaatgcc      600

tgccgggatg tggaggcccc ctcaagtaat gacaaggccc tgggactcct gtgtgggaag      660

gacgctgacg cctgtaatgc caccaactgg attgaataca tgttcaataa ggacaatgga      720

caggcacctt ttaccatcac tcctgtgttt tcagattttc cagtccatgg gatggagccc      780

atgaacaatg ccaccaaagg ctgtgacgag tctgtggatg aggtcacagc accatgtagc      840

tgccaagact gctctattgt ctgtggcccc aagccccagc ccccacctcc tcctgctccc      900

tggacgatcc ttggcttgga cgccatgtat gtcatcatgt ggatcaccta catggcgttt      960

ttgcttgtgt tttttggagc attttttgca gtgtggtgct acagaaaacg gtattttgtc     1020

tccgagtaca ctcccatcga tagcaatata gctttttctg ttaatgcaag tgacaaagga     1080

gaggcgtcct gctgtgaccc tgtcagcgca gcatttgagg gctgcttgag gcggctgttc     1140

acacgctggg ggtctttctg cgtccgaaac cctggctgtg tcattttctt ctcgctggtc     1200

ttcattactg cgtgttcgtc aggcctggtg tttgtccggg tcacaaccaa tccagttgac     1260

ctctggtcag cccccagcag ccaggctcgc ctggaaaaag agtactttga ccagcacttt     1320

gggcctttct tccggacgga gcagctcatc atccgggccc ctctcactga caaacacatt     1380

taccagccat acccttcggg agctgatgta ccctttggac ctccgcttga catacagata     1440

ctgcaccagg ttcttgactt acaaatagcc atcgaaaaca ttactgcctc ttatgacaat     1500

gagactgtga cacttcaaga catctgcttg gcccctcttt caccgtataa cacgaactgc     1560

accattttga gtgtgttaaa ttacttccag aacagccatt ccgtgctgga ccacaagaaa     1620

ggggacgact tctttgtgta tgccgattac cacacgcact ttctgtactg cgtacgggct     1680

cctgcctctc tgaatgatac aagtttgctc catgaccctt gtctgggtac gtttggtgga     1740

ccagtgttcc cgtggcttgt gttgggaggc tatgatgatc aaaactacaa taacgccact     1800

gcccttgtga ttaccttccc tgtcaataat tactataatg atacagagaa gctccagagg     1860

gcccaggcct gggaaaaaga gtttattaat tttgtgaaaa actacaagaa tcccaatctg     1920

accatttcct tcactgctga acgaagtatt gaagatgaac taaatcgtga aagtgacagt     1980

gatgtcttca ccgttgtaat tagctatgcc atcatgtttc tatatatttc cctagccttg     2040

gggcacatca aaagctgtcg caggcttctg gtggattcga aggtctcact aggcatcgcg     2100

ggcatcttga tcgtgctgag ctcggtggct tgctccttgg gtgtcttcag ctacattggg     2160

ttgcccttga ccctcattgt gattgaagtc atcccgttcc tggtgctggc tgttggagtg     2220

gacaacatct tcattctggt gcaggcctac cagagagatg aacgtcttca aggggaaacc     2280

ctggatcagc agctgggcag ggtcctagga gaagtggctc ccagtatgtt cctgtcatcc     2340

ttttctgaga ctgtagcatt tttcttagga gcattgtccg tgatgccagc cgtgcacacc     2400

ttctctctct ttgcgggatt ggcagtcttc attgactttc ttctgcagat tacctgtttc     2460

gtgagtctct tggggttaga cattaaacgt caagagaaaa atcggctaga catcttttgc     2520

tgtgtcagag gtgctgaaga tggaacaagc gtccaggcct cagagagctg tttgtttcgc     2580

ttcttcaaaa actcctattc tccacttctg ctaaaggact ggatgagacc aattgtgata     2640

gcaatatttg tgggtgttct gtcattcagc atcgcagtcc tgaacaaagt agatattgga     2700

ttggatcagt ctctttcgat gccagatgac tcctacatgg tggattattt caaatccatc     2760

agtcagtacc tgcatgcggg tccgcctgtg tactttgtcc tggaggaagg gcacgactac     2820

acttcttcca aggggcagaa catggtgtgc ggcggcatgg gctgcaacaa tgattccctg     2880

gtgcagcaga tatttaacgc ggcgcagctg gacaactata cccgaatagg cttcgccccc     2940

tcgtcctgga tcgacgatta tttcgactgg gtgaagccac agtcgtcttg ctgtcgagtg     3000

gacaatatca ctgaccagtt ctgcaatgct tcagtggttg accctgcctg cgttcgctgc     3060

aggcctctga ctccggaagg caaacagagg cctcaggggg gagacttcat gagattcctg     3120

cccatgttcc tttcggataa ccctaacccc aagtgtggca aagggggaca tgctgcctat     3180

agttctgcag ttaacatcct ccttggccat ggcaccaggg tcggagccac gtacttcatg     3240

acctaccaca ccgtgctgca gacctctgct gactttattg acgctctgaa gaaagcccga     3300

cttatagcca gtaatgtcac cgaaaccatg ggcattaacg gcagtgccta ccgagtattt     3360

ccttacagtg tgttttatgt cttctacgaa cagtacctga ccatcattga cgacactatc     3420

ttcaacctcg gtgtgtccct gggcgcgata tttctggtga ccatggtcct cctgggctgt     3480

gagctctggt ctgcagtcat catgtgtgcc accatcgcca tggtcttggt caacatgttt     3540

ggagttatgt ggctctgggg catcagtctg aacgctgtat ccttggtcaa cctggtgatg     3600

agctgtggca tctccgtgga gttctgcagc cacataacca gagcgttcac ggtgagcatg     3660

aaaggcagcc gcgtggagcg cgcggaagag gcacttgccc acatgggcag ctccgtgttc     3720

agtggaatca cacttacaaa atttggaggg attgtggtgt tggcttttgc caaatctcaa     3780

attttccaga tattctactt caggatgtat ttggccatgg tcttactggg agccactcac     3840

ggattaatat ttctccctgt cttactcagt tacatagggc catcagtaaa taaagccaaa     3900

agttgtgcca ctgaagagcg atacaaagga acagagcgcg aacggcttct aaatttctag     3960

ccctctcgca gggcatcctg actgaactgt gtctaagggt cggtcggttt accactggac     4020

gggtgctgca tcggcaaggc caagttgaac accggatggt gccaaccatc ggttgtttgg     4080

cagcagcttt gaacgtagcg cctgtgaact caggaatgca cagttgactt gggaagcagt     4140

attactagat ctggaggcaa ccacaggaca ctaaacttct cccagcctct tcaggaaaga     4200

aacctcattc tttggcaagc aggaggtgac actagatggc tgtgaatgtg atccgctcac     4260

tgacactctg taaaggccaa tcaatgcact gtctgtcctc tcctttttag gagtaagcca     4320

tcccacaagt tctataccat atttttagtg acagttgagg ttgtagatac actttataac     4380

attttatagt ttaaagagct ttattaatgc aataaattaa ctttgtacac atttttatat     4440

aaaaaaacag caagtgattt cagaatgttg taggcctcat tagagcttgg tctccaaaaa     4500

tctgtttgaa aaaagcaaca tgttcttcac agtgttcccc tagaaaggaa gagatttaat     4560

tgccagttag atgtggcatg aaatgaggga caaagaaagc atctcgtagg tgtgtctact     4620

gggttttaac ttatttttct ttaataaaat acattgtttt cctaaaaaaa aaa            4673


<210>  21
<211>  410
<212>  PRT
<213>  homo sapiens

<400>  21

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Asp Cys 
        355                 360                 365             


Ser Ala Asp Asp Asp Asn Phe Leu Val Pro Ile Ala Val Gly Ala Ala 
    370                 375                 380                 


Leu Ala Gly Val Leu Ile Leu Val Leu Leu Ala Tyr Phe Ile Gly Leu 
385                 390                 395                 400 


Lys His His His Ala Gly Tyr Glu Gln Phe 
                405                 410 


<210>  22
<211>  1868
<212>  DNA
<213>  homo sapiens

<400>  22
ccgattcctg gcttttgcaa ggctgtggtc ggtggtcatc agtgctcttg acccaggtcc       60

agcgagcctt ttccctggtg ttgcagctgt tgttgtaccg ccgccgtcgc cgccgtcgcc      120

gcctgctctg cggggtcatg gtgtgcttcc gcctcttccc ggttccgggc tcagggctcg      180

ttctggtctg cctagtcctg ggagctgtgc ggtcttatgc attggaactt aatttgacag      240

attcagaaaa tgccacttgc ctttatgcaa aatggcagat gaatttcaca gtacgctatg      300

aaactacaaa taaaacttat aaaactgtaa ccatttcaga ccatggcact gtgacatata      360

atggaagcat ttgtggggat gatcagaatg gtcccaaaat agcagtgcag ttcggacctg      420

gcttttcctg gattgcgaat tttaccaagg cagcatctac ttattcaatt gacagcgtct      480

cattttccta caacactggt gataacacaa catttcctga tgctgaagat aaaggaattc      540

ttactgttga tgaacttttg gccatcagaa ttccattgaa tgaccttttt agatgcaata      600

gtttatcaac tttggaaaag aatgatgttg tccaacacta ctgggatgtt cttgtacaag      660

cttttgtcca aaatggcaca gtgagcacaa atgagttcct gtgtgataaa gacaaaactt      720

caacagtggc acccaccata cacaccactg tgccatctcc tactacaaca cctactccaa      780

aggaaaaacc agaagctgga acctattcag ttaataatgg caatgatact tgtctgctgg      840

ctaccatggg gctgcagctg aacatcactc aggataaggt tgcttcagtt attaacatca      900

accccaatac aactcactcc acaggcagct gccgttctca cactgctcta cttagactca      960

atagcagcac cattaagtat ctagactttg tctttgctgt gaaaaatgaa aaccgatttt     1020

atctgaagga agtgaacatc agcatgtatt tggttaatgg ctccgttttc agcattgcaa     1080

ataacaatct cagctactgg gatgcccccc tgggaagttc ttatatgtgc aacaaagagc     1140

agactgtttc agtgtctgga gcatttcaga taaatacctt tgatctaagg gttcagcctt     1200

tcaatgtgac acaaggaaag tattctacag ctcaagactg cagtgcagat gacgacaact     1260

tccttgtgcc catagcggtg ggagctgcct tggcaggagt acttattcta gtgttgctgg     1320

cttattttat tggtctcaag caccatcatg ctggatatga gcaattttag aatctgcaac     1380

ctgattgatt atataaaaat acatgcaaat aacaagattt tcttacctct cagttgttga     1440

aacactttgc ttcttaaaat tgatatgttg aaactttaat tcttttatca atcccagcat     1500

tttgagatca gtctttatta ataaaacctg ttctctttaa tcagcttaaa atccaaagtg     1560

tcatatttac tggtcctgga gacaaacttg ttcaaaagaa catcaacgtg caatgtttta     1620

aggtctatct taagaagccc tggccaaatt ttgatcctaa ccttgaagta tgccttgaac     1680

ttattaacat ggccattata agaataaaat atgtagttgt gtcttaatgg aattaataaa     1740

tgtcatttca ctactggtgt tctgttttca atgtataagg actatagtga tttaaactca     1800

tcaatgtgcc tttgcataaa gttgattaaa taaatattga tgtggtataa atgcccatca     1860

gatatgct                                                              1868


<210>  23
<211>  410
<212>  PRT
<213>  homo sapiens

<400>  23

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln Glu Cys 
        355                 360                 365             


Ser Leu Asp Asp Asp Thr Ile Leu Ile Pro Ile Ile Val Gly Ala Gly 
    370                 375                 380                 


Leu Ser Gly Leu Ile Ile Val Ile Val Ile Ala Tyr Val Ile Gly Arg 
385                 390                 395                 400 


Arg Lys Ser Tyr Ala Gly Tyr Gln Thr Leu 
                405                 410 


<210>  24
<211>  4006
<212>  DNA
<213>  homo sapiens

<400>  24
ccgattcctg gcttttgcaa ggctgtggtc ggtggtcatc agtgctcttg acccaggtcc       60

agcgagcctt ttccctggtg ttgcagctgt tgttgtaccg ccgccgtcgc cgccgtcgcc      120

gcctgctctg cggggtcatg gtgtgcttcc gcctcttccc ggttccgggc tcagggctcg      180

ttctggtctg cctagtcctg ggagctgtgc ggtcttatgc attggaactt aatttgacag      240

attcagaaaa tgccacttgc ctttatgcaa aatggcagat gaatttcaca gtacgctatg      300

aaactacaaa taaaacttat aaaactgtaa ccatttcaga ccatggcact gtgacatata      360

atggaagcat ttgtggggat gatcagaatg gtcccaaaat agcagtgcag ttcggacctg      420

gcttttcctg gattgcgaat tttaccaagg cagcatctac ttattcaatt gacagcgtct      480

cattttccta caacactggt gataacacaa catttcctga tgctgaagat aaaggaattc      540

ttactgttga tgaacttttg gccatcagaa ttccattgaa tgaccttttt agatgcaata      600

gtttatcaac tttggaaaag aatgatgttg tccaacacta ctgggatgtt cttgtacaag      660

cttttgtcca aaatggcaca gtgagcacaa atgagttcct gtgtgataaa gacaaaactt      720

caacagtggc acccaccata cacaccactg tgccatctcc tactacaaca cctactccaa      780

aggaaaaacc agaagctgga acctattcag ttaataatgg caatgatact tgtctgctgg      840

ctaccatggg gctgcagctg aacatcactc aggataaggt tgcttcagtt attaacatca      900

accccaatac aactcactcc acaggcagct gccgttctca cactgctcta cttagactca      960

atagcagcac cattaagtat ctagactttg tctttgctgt gaaaaatgaa aaccgatttt     1020

atctgaagga agtgaacatc agcatgtatt tggttaatgg ctccgttttc agcattgcaa     1080

ataacaatct cagctactgg gatgcccccc tgggaagttc ttatatgtgc aacaaagagc     1140

agactgtttc agtgtctgga gcatttcaga taaatacctt tgatctaagg gttcagcctt     1200

tcaatgtgac acaaggaaag tattctacag cccaagagtg ttcgctggat gatgacacca     1260

ttctaatccc aattatagtt ggtgctggtc tttcaggctt gattatcgtt atagtgattg     1320

cttacgtaat tggcagaaga aaaagttatg ctggatatca gactctgtaa cactaatcaa     1380

tacgtgatct ctgttacaaa agaaaaaagc aagtacaagt tccaacatgc aatactggtc     1440

aacttaaggt atatttagtt gcagtccagc tctttagaat gggtggtatg ggggatttca     1500

aacttaaaca aaaaactatc aactacaaat tagttgcctg actttggttt ttccaaccaa     1560

ggaatttaaa actgttattt ttacagcaaa agatgtgcaa aatcactgga ttataagttc     1620

tattttactg tcttgaatta gtatttcagt gttttcattt tagacattca gactaaaaat     1680

acaccgttta gaaaaaacaa tttttgaaaa agagattttt tttccctgca ggtagttgag     1740

ttgaacaaca tgttctaccg tggatttgta cttgctcctt ttgctctttt tgtgtgtgtg     1800

tgtgtgtgtg tgtgtgtgtg tgtgattttt gtttgcaggt taacttagct actttggcat     1860

tgctgcatat ttgacctttg agagatataa tagtagattt gaacaggggc tggtattatt     1920

atgttcttag caataaatgc ttttctaatg ccttttgaat acatttgtat ttatgtggct     1980

gtaatgacaa aagatacaaa agctttttaa aatttagagt aggtattaat cttattgttt     2040

aatctttttt ttaaaaaaac tggatatttc aatcttttaa attgcaatat ataagactat     2100

tccaactggg catttcaatc cattttttag gtgctttaga gataattgct tgccagtgcc     2160

aattgagggc attagtactt tgtgctcata aattggcctc tgtatgcagt actaaaatta     2220

atgcagattt ctctttagcc ttccaacatt tcttgttgat agtgatgtat tttattattt     2280

tctttttctt aagaaatgcc agtgtgtcct agaacctaga taacgaagtg cacttacact     2340

tataaaataa cttgcatcta ggctgggcgt ggcggctcac gcctgtaatc ccagcacttt     2400

gggaggccga agtgggtgga tcacttgagg ccaggagttt gagaccagcc tggccaacat     2460

ggtgaaaccc catctctatc agaaatacaa aaaattagct gggcatggtg gtgggcgcct     2520

gtaatcccag ttactcggga ggctgaggca ggagaatcac ttgaacccgg gaggcagagg     2580

ttgcggtgag ccaagagcgc accattgcac tccagccttg ggcgacaaaa acgaaactcc     2640

atcttcaaaa caaaacaaaa caaaacaaac aaacaaacaa aacttgcatc ttaaccaaaa     2700

gtcttggttt tatcttaatc cattaaaagt tggtcttgtt tccagcttgc attgattgct     2760

acaacatcac taatttggct ttcacattta aatggttctg tgctaatcaa aactttcgtt     2820

gttattattc gttatggtag aatcattttt aattcacgtg ctttgtgttc agttttgtgg     2880

tctgagagat gtaccaattg tcaaattacc gtgtaccacc taatgtttat aggagaaagc     2940

aaaatacatc agcttggtag ttaacacatc aaatatttct tgctgcttct aggagaactt     3000

ttttggtgtg tgttggaatg gctgagcaaa tattaaaatt gttaatatgc agccatatat     3060

ggaaggttcc tgtggggttg ttttttcgtg tttttttttt ttgtggtggg attatgtgcc     3120

tcccattcac tagaaaatga gaaaattgtc tgggttccaa aatattgaca ttgaatggat     3180

caatacacac acacagacat atatatatat atatgcacac atatataggc agttgcatgc     3240

ctagcatggg tattttataa ccatataact gagttatatt ggaattataa atattttccg     3300

tcacttaaat ttgttctttg tttagcctga aaacctttat ggctcaagat cagattcctg     3360

actaacccct ctcttagagc tacagcgagc tgcattacca gcttaaaaca cttcttaggg     3420

attaaatata gatgtaattt ttcaaaatcg tttttaattt aaactgtgtt ttagtgtaaa     3480

attgttaacc ttgtaagatg gataatgtgt ataagaatgt aggccttaac tatttcacat     3540

gagtcaaaac aaagcagctt taaaaaaata attggaagca caatgcatgg cactgactga     3600

atgctgttaa tatttctaaa agtttctaca ttcagattat atgcctgatt catagtaaaa     3660

tacctctaat aaacactgtt ttatagaaaa cctgacttca gtgaatattt ttgtatttta     3720

catgggccag tttatatact gctatttaca ctattatttc ctatagctac atgttctttg     3780

taccttttgt agttttattt gtattactag attcatacct tgatggtaac gctctatctg     3840

gttttgggtg tttttcatgt tttagcattt gtataaagaa actggtccat gtaaatactt     3900

tccatgtttt ttcttcaaat gtttaaacca ctagttgatg tatggtatct ttagatattt     3960

gcctgtctgt ttgctcaaaa ttgcttctaa aacaataaag attctt                    4006


<210>  25
<211>  411
<212>  PRT
<213>  homo sapiens

<400>  25

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Glu Glu Cys 
        355                 360                 365             


Ser Ala Asp Ser Asp Leu Asn Phe Leu Ile Pro Val Ala Val Gly Val 
    370                 375                 380                 


Ala Leu Gly Phe Leu Ile Ile Val Val Phe Ile Ser Tyr Met Ile Gly 
385                 390                 395                 400 


Arg Arg Lys Ser Arg Thr Gly Tyr Gln Ser Val 
                405                 410     


<210>  26
<211>  1236
<212>  DNA
<213>  homo sapiens

<400>  26
atggtgtgct tccgcctctt cccggttccg ggctcagggc tcgttctggt ctgcctagtc       60

ctgggagctg tgcggtctta tgcattggaa cttaatttga cagattcaga aaatgccact      120

tgcctttatg caaaatggca gatgaatttc acagtacgct atgaaactac aaataaaact      180

tataaaactg taaccatttc agaccatggc actgtgacat ataatggaag catttgtggg      240

gatgatcaga atggtcccaa aatagcagtg cagttcggac ctggcttttc ctggattgcg      300

aattttacca aggcagcatc tacttattca attgacagcg tctcattttc ctacaacact      360

ggtgataaca caacatttcc tgatgctgaa gataaaggaa ttcttactgt tgatgaactt      420

ttggccatca gaattccatt gaatgacctt tttagatgca atagtttatc aactttggaa      480

aagaatgatg ttgtccaaca ctactgggat gttcttgtac aagcttttgt ccaaaatggc      540

acagtgagca caaatgagtt cctgtgtgat aaagacaaaa cttcaacagt ggcacccacc      600

atacacacca ctgtgccatc tcctactaca acacctactc caaaggaaaa accagaagct      660

ggaacctatt cagttaataa tggcaatgat acttgtctgc tggctaccat ggggctgcag      720

ctgaacatca ctcaggataa ggttgcttca gttattaaca tcaaccccaa tacaactcac      780

tccacaggca gctgccgttc tcacactgct ctacttagac tcaatagcag caccattaag      840

tatctagact ttgtctttgc tgtgaaaaat gaaaaccgat tttatctgaa ggaagtgaac      900

atcagcatgt atttggttaa tggctccgtt ttcagcattg caaataacaa tctcagctac      960

tgggatgccc ccctgggaag ttcttatatg tgcaacaaag agcagactgt ttcagtgtct     1020

ggagcatttc agataaatac ctttgatcta agggttcagc ctttcaatgt gacacaagga     1080

aagtattcta cagctgaaga atgttctgct gactctgacc tcaactttct tattcctgtt     1140

gcagtgggtg tggccttggg cttccttata attgttgtct ttatctctta tatgattgga     1200

agaaggaaaa gtcgtactgg ttatcagtct gtgtaa                               1236


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

His His His His His His 
1               5       


