                         SEQUENCE LISTING

<110>  DURING, Matthew
 
<120>  USE OF DESIGNER RECEPTORS EXCLUSIVELY ACTIVATED BY DESIGNER DRUGS
        IN THE TREATMENT OF SEIZURE DISORDERS

<130>  2262-32

<150>  US 62/471,635
<151>  2017-03-15

<150>  US 62/608,207
<151>  2017-12-20

<150>  US 62/635,871
<151>  2018-02-27

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  7169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pAM/CaMKII-hM4D(Gi)-WPRE-BGHpA

<400>  1
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggtact cgagcattat ggccttaggt cacttcatct ccatggggtt cttcttctga      240

ttttctagaa aatgagatgg gggtgcagag agcttcctca gtgacctgcc cagggtcaca      300

tcagaaatgt cagagctaga acttgaactc agattactaa tcttaaattc catgccttgg      360

gggcatgcaa gtacgatata cagaaggagt gaactcatta gggcagatga ccaatgagtt      420

taggaaagaa gagtccaggg cagggtacat ctacaccacc cgcccagccc tgggtgagtc      480

cagccacgtt cacctcatta tagttgcctc tctccagtcc taccttgacg ggaagcacaa      540

gcagaaactg ggacaggagc cccaggagac caaatcttca tggtccctct gggaggatgg      600

gtggggagag ctgtggcaga ggcctcagga ggggccctgc tgctcagtgg tgacagatag      660

gggtgagaaa gcagacagag tcattccgtc agcattctgg gtctgtttgg tacttcttct      720

cacgctaagg tggcggtgtg atatgcacaa tggctaaaaa gcagggagag ctggaaagaa      780

acaaggacag agacagaggc caagtcaacc agaccaattc ccagaggaag caaagaaacc      840

attacagaga ctacaagggg gaagggaagg agagatgaat tagcttcccc tgtaaacctt      900

agaacccagc tgttgccagg gcaacggggc aatacctgtc tcttcagagg agatgaagtt      960

gccagggtaa ctacatcctg tctttctcaa ggaccatccc agaatgtggc acccactagc     1020

cgttaccata gcaactgcct ctttgcccca cttaatccca tcccgtctgt taaaagggcc     1080

ctatagttgg aggtggggga ggtaggaaga gcgatgatca cttgtggact aagtttgttc     1140

gcatcccctt ctccaacccc ctcagtacat caccctgggg gaacagggtc cacttgctcc     1200

tgggcccaca cagtcctgca gtattgtgta tataaggcca gggcaaagag gagcaggttt     1260

taaagtgaaa ggcaggcagg tgttggggag gcagttaccg gggcaacggg aacagggcgt     1320

ttcggaggtg gttgccatgg ggacctggat gctgacgaag gctcgcgagg ctgtgagcag     1380

ccacagtgcc ctgctcagaa gccccaagct cgtcagtcaa gccggttctc cgtttgcact     1440

caggagcacg ggcaggcgag tggcccctag ttctgggggc agcgcttcag catcccagcc     1500

ctagttccca gggatccaag ctgaattcat ggccaacttc acacctgtca atggcagctc     1560

gggcaatcag tccgtgcgcc tggtcacgtc atcatcccac aatcgctatg agacggtgga     1620

aatggtcttc attgccacag tgacaggctc cctgagcctg gtgactgtcg tgggcaacat     1680

cctggtgatg ctgtccatca aggtcaacag gcagctgcag acagtcaaca actacttcct     1740

cttcagcctg gcgtgtgctg atctcatcat aggcgccttc tccatgaacc tctacaccgt     1800

gtacatcatc aagggctact ggcccctggg cgccgtggtc tgcgacctgt ggctggccct     1860

ggactgcgtg gtgagcaacg cctccgtcat gaaccttctc atcatcagct ttgaccgcta     1920

cttctgcgtc accaagcctc tcacctaccc tgcccggcgc accaccaaga tggcaggcct     1980

catgattgct gctgcctggg tactgtcctt cgtgctctgg gcgcctgcca tcttgttctg     2040

gcagtttgtg gtgggtaagc ggacggtgcc cgacaaccag tgcttcatcc agttcctgtc     2100

caacccagca gtgacctttg gcacagccat tgctggcttc tacctgcctg tggtcatcat     2160

gacggtgctg tacatccaca tctccctggc cagtcgcagc cgagtccaca agcaccggcc     2220

cgagggcccg aaggagaaga aagccaagac gctggccttc ctcaagagcc cactaatgaa     2280

gcagagcgtc aagaagcccc cgcccgggga ggccgcccgg gaggagctgc gcaatggcaa     2340

gctggaggag gcccccccgc cagcgctgcc accgccaccg cgccccgtgg ctgataagga     2400

cacttccaat gagtccagct caggcagtgc cacccagaac accaaggaac gcccagccac     2460

agagctgtcc accacagagg ccaccacgcc cgccatgccc gcccctcccc tgcagccgcg     2520

ggccctcaac ccagcctcca gatggtccaa gatccagatt gtgacgaagc agacaggcaa     2580

tgagtgtgtg acagccattg agattgtgcc tgccacgccg gctggcatgc gccctgcggc     2640

caacgtggcc cgcaagttcg ccagcatcgc tcgcaaccag gtgcgcaaga agcggcagat     2700

ggcggcccgg gagcgcaaag tgacacgaac gatctttgcc attctgctgg ccttcatcct     2760

cacctggacg ccctacaacg tcatggtcct ggtgaacacc ttctgccaga gctgcatccc     2820

tgacacggtg tggtccattg gctactggct ctgctacgtc aacagcacca tcaaccctgc     2880

ctgctatgct ctgtgcaacg ccacctttaa aaagaccttc cggcacctgc tgctgtgcca     2940

gtatcggaac atcggcactg ccaggtagaa gcttatcgat aatcaacctc tggattacaa     3000

aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc tatgtggata     3060

cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca ttttctcctc     3120

cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg tcaggcaacg     3180

tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca ttgccaccac     3240

ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg cggaactcat     3300

cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg acaattccgt     3360

ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg ccacctggat     3420

tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg accttccttc     3480

ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag     3540

tcggatctcc ctttgggccg cctccccgca tcgataccgt cgactcgctg atcagcctcg     3600

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     3660

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     3720

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     3780

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggcttc tgaggcggaa     3840

agaaccagct ggggctcgac tagagcatgg ctacgtagat aagtagcatg gcgggttaat     3900

cattaactac aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc     3960

gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc     4020

agtgagcgag cgagcgcgca gagctttttg caaaagccta ggcctccaaa aaagcctcct     4080

cactacttct ggaatagctc agaggccgag gcggcctcgg cctctgcata aataaaaaaa     4140

attagtcagc catggggcgg agaatgggcg gaactgggcg gagttagggg cgggatgggc     4200

ggagttaggg gcgggactat ggttgctgac taattgagat gcatgctttg catacttctg     4260

cctgctgggg agcctgggga ctttccacac ctggttgctg actaattgag atgcatgctt     4320

tgcatacttc tgcctgctgg ggagcctggg gactttccac accctaactg acacacattc     4380

cacagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct     4440

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat     4500

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4560

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4620

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4680

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4740

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4800

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4860

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4920

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4980

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc     5040

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     5100

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg     5160

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt     5220

tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg     5280

tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta     5340

aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg     5400

aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg     5460

tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc     5520

gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg     5580

agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg     5640

aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag     5700

gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat     5760

caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc     5820

cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc     5880

ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa     5940

ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac     6000

gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt     6060

cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc     6120

gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa     6180

caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca     6240

tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat     6300

acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa     6360

aagtgccacc tgacgtctaa gaaaccatta ttatcatgac attaacctat aaaaataggc     6420

gtatcacgag gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca     6480

tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc     6540

gtcagggcgc gtcagcgggt gttggcgggt gtcggggctg gcttaactat gcggcatcag     6600

agcagattgt actgagagtg caccattcga cgctctccct tatgcgactc ctgcattagg     6660

aagcagccca gtagtaggtt gaggccgttg agcaccgccg ccgcaaggaa tggtgcatgc     6720

aaggagatgg cgcccaacag tcccccggcc acggggcctg ccaccatacc cacgccgaaa     6780

caagcgctca tgagcccgaa gtggcgagcc cgatcttccc catcggtgat gtcggcgata     6840

taggcgccag caaccgcacc tgtggcgccg gtgatgccgg ccacgatgcg tccggcgtag     6900

aggatctggc tagcgatgac cctgctgatt ggttcgctga ccatttccgg gtgcgggacg     6960

gcgttaccag aaactcagaa ggttcgtcca accaaaccga ctctgacggc agtttacgag     7020

agagatgata gggtctgctt cagtaagcca gatgctacac aattaggctt gtacatattg     7080

tcgttagaac gcggctacaa ttaatacata accttatgta tcatacacat acgatttagg     7140

tgacactata gaatacacgg aattaattc                                       7169


<210>  2
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAVRec3 Amino Acid Sequence

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Gly Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Arg Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  3
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  3
atctaggaat tcatggccaa cttcacacct gtc                                    33


<210>  4
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  4
atctagaagc ttctacctgg cagtgccgat gttccg                                 36


<210>  5
<211>  7209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct: pAM/hCaMK2A-h4MD(Gi)-WPRE-BGHpA

<400>  5
tagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc       60

tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc      120

actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc      180

tctaggtact cgaggtcgac ggtatcgcga taagcttgat atcgaattcc acggggttaa      240

tcgaataaat aaataaataa ataatataaa taataaatgt ccaggaatca gagctcaaac      300

tcagatcctt agtcttaaac tccagtccct tttcttccta actccaagac cttggagtaa      360

gatcttgtgg ctgtaggtat ggctgatgcc ctgaagagtt gaagttggca gggaaggtgc      420

ccagaaaatt ttggattgaa gatttcatgg caagtctctg gccagtggcc tagcccgggt      480

aagccatgct atgctcacct ccccacagcc ccctctcgcc tttttttttt tttttttttt      540

taccttgact ggaagcacaa gcagaaactg ggacatgagc accaggagac cagatttcca      600

tggtcccgtt gggggcatgg ggttggggag aggttgcaga ggagggctct ggaggggagc      660

aactgtcaca gctgtgagag gtgggggtga gcaggcagtc agggctgttc cctccagaat      720

cctggggtgt cctctgcact tctgcgccaa gctggagtgc tagtgtgatg gacaaggtgg      780

taagagagct gaaagagcac gagcataaca agaaagacag aggcagaagc aaaaaaaaaa      840

aaaaaaaaaa aacagagggc aacagagaga cagttacaga gactacagtg atccacagag      900

ggagagccat ccctgtgaat tagccatcat ttccctgtaa accttagaac ccagctgttg      960

ccagggcaac ggggcaatac ctgtctctct agagatgaag ttgccagggt aactgcatcc     1020

tgtcattcgt tcctggggac catccggaat gcggcaccca ctggctgtta ccatggcaac     1080

tgcctttttg ccccacttaa tcccatcccg tctgctacaa gggccccaca gttggaggtg     1140

ggggaggtgg gaagagaaaa gatcacttgt ggacaaagtt tgctctattc cacctcctcc     1200

aggccctcct tgggtccatc accccagggg tgctgggtcc atcccacccc caggcccaca     1260

caggcttgca gtattgtgtg cggtatggtc agggcgtccg agagcaggtt tcgcagtgga     1320

aggcaggcag gtgttgggga ggcagttacc ggggcaacgg gaacagggcg ttttggaggt     1380

ggttgccatg gggacctgga tgctgacgaa ggctcgcgag gctgtgagca gccacagtgc     1440

cctgctcaga agccccgggc tcgtcagtca aaccggttct ctgtttgcac tcggcagcac     1500

gggcaggcaa gtggtcccta ggttcgggag cagagcagca gcgcccccgg gggatccaag     1560

ctgaattcat ggccaacttc acacctgtca atggcagctc gggcaatcag tccgtgcgcc     1620

tggtcacgtc atcatcccac aatcgctatg agacggtgga aatggtcttc attgccacag     1680

tgacaggctc cctgagcctg gtgactgtcg tgggcaacat cctggtgatg ctgtccatca     1740

aggtcaacag gcagctgcag acagtcaaca actacttcct cttcagcctg gcgtgtgctg     1800

atctcatcat aggcgccttc tccatgaacc tctacaccgt gtacatcatc aagggctact     1860

ggcccctggg cgccgtggtc tgcgacctgt ggctggccct ggactgcgtg gtgagcaacg     1920

cctccgtcat gaaccttctc atcatcagct ttgaccgcta cttctgcgtc accaagcctc     1980

tcacctaccc tgcccggcgc accaccaaga tggcaggcct catgattgct gctgcctggg     2040

tactgtcctt cgtgctctgg gcgcctgcca tcttgttctg gcagtttgtg gtgggtaagc     2100

ggacggtgcc cgacaaccag tgcttcatcc agttcctgtc caacccagca gtgacctttg     2160

gcacagccat tgctggcttc tacctgcctg tggtcatcat gacggtgctg tacatccaca     2220

tctccctggc cagtcgcagc cgagtccaca agcaccggcc cgagggcccg aaggagaaga     2280

aagccaagac gctggccttc ctcaagagcc cactaatgaa gcagagcgtc aagaagcccc     2340

cgcccgggga ggccgcccgg gaggagctgc gcaatggcaa gctggaggag gcccccccgc     2400

cagcgctgcc accgccaccg cgccccgtgg ctgataagga cacttccaat gagtccagct     2460

caggcagtgc cacccagaac accaaggaac gcccagccac agagctgtcc accacagagg     2520

ccaccacgcc cgccatgccc gcccctcccc tgcagccgcg ggccctcaac ccagcctcca     2580

gatggtccaa gatccagatt gtgacgaagc agacaggcaa tgagtgtgtg acagccattg     2640

agattgtgcc tgccacgccg gctggcatgc gccctgcggc caacgtggcc cgcaagttcg     2700

ccagcatcgc tcgcaaccag gtgcgcaaga agcggcagat ggcggcccgg gagcgcaaag     2760

tgacacgaac gatctttgcc attctgctgg ccttcatcct cacctggacg ccctacaacg     2820

tcatggtcct ggtgaacacc ttctgccaga gctgcatccc tgacacggtg tggtccattg     2880

gctactggct ctgctacgtc aacagcacca tcaaccctgc ctgctatgct ctgtgcaacg     2940

ccacctttaa aaagaccttc cggcacctgc tgctgtgcca gtatcggaac atcggcactg     3000

ccaggtagaa gcttatcgat aatcaacctc tggattacaa aatttgtgaa agattgactg     3060

gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt     3120

atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc     3180

tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt     3240

ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga     3300

ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct     3360

gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat     3420

cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct     3480

gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc     3540

tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg     3600

cctccccgca tcgataccgt cgactcgctg atcagcctcg actgtgcctt ctagttgcca     3660

gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac     3720

tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat     3780

tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca atagcaggca     3840

tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct ggggctcgac     3900

tagagcatgg ctacgtagat aagtagcatg gcgggttaat cattaactac aaggaacccc     3960

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     4020

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     4080

gagctttttg caaaagccta ggcctccaaa aaagcctcct cactacttct ggaatagctc     4140

agaggccgag gcggcctcgg cctctgcata aataaaaaaa attagtcagc catggggcgg     4200

agaatgggcg gaactgggcg gagttagggg cgggatgggc ggagttaggg gcgggactat     4260

ggttgctgac taattgagat gcatgctttg catacttctg cctgctgggg agcctgggga     4320

ctttccacac ctggttgctg actaattgag atgcatgctt tgcatacttc tgcctgctgg     4380

ggagcctggg gactttccac accctaactg acacacattc cacagctgca ttaatgaatc     4440

ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact     4500

gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta     4560

atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag     4620

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     4680

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     4740

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     4800

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     4860

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     4920

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     4980

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     5040

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     5100

agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     5160

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     5220

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     5280

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     5340

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     5400

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     5460

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     5520

gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct     5580

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     5640

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg     5700

ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg     5760

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc     5820

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag     5880

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg     5940

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag     6000

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat     6060

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg     6120

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca     6180

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca     6240

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat     6300

tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag     6360

aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtctaa     6420

gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag gccctttcgt     6480

ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc     6540

acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt     6600

gttggcgggt gtcggggctg gcttaactat gcggcatcag agcagattgt actgagagtg     6660

caccattcga cgctctccct tatgcgactc ctgcattagg aagcagccca gtagtaggtt     6720

gaggccgttg agcaccgccg ccgcaaggaa tggtgcatgc aaggagatgg cgcccaacag     6780

tcccccggcc acggggcctg ccaccatacc cacgccgaaa caagcgctca tgagcccgaa     6840

gtggcgagcc cgatcttccc catcggtgat gtcggcgata taggcgccag caaccgcacc     6900

tgtggcgccg gtgatgccgg ccacgatgcg tccggcgtag aggatctggc tagcgatgac     6960

cctgctgatt ggttcgctga ccatttccgg gtgcgggacg gcgttaccag aaactcagaa     7020

ggttcgtcca accaaaccga ctctgacggc agtttacgag agagatgata gggtctgctt     7080

cagtaagcca gatgctacac aattaggctt gtacatattg tcgttagaac gcggctacaa     7140

ttaatacata accttatgta tcatacacat acgatttagg tgacactata gaatacacgg     7200

aattaattc                                                             7209


