                         SEQUENCE LISTING

<110>  Baylor College of Medicine
 
<120>  Dominant Active Yap, a Hippo Effector, Induces Chromatin 
       Accessibility and Cardiomyocyte Renewal

<130>  BAYM.P0223WO

<140>  62/471,204
<141>  2017-03-14

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  488
<212>  PRT
<213>  Synthetic protein

<400>  1

Met Asp Pro Gly Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Gln 
1               5                   10                  15      


Gly Gln Pro Pro Ser Gln Pro Pro Gln Gly Gln Gly Pro Pro Ser Gly 
            20                  25                  30          


Pro Gly Gln Pro Ala Pro Ala Ala Thr Gln Ala Ala Pro Gln Ala Pro 
        35                  40                  45              


Pro Ala Gly His Gln Ile Val His Val Arg Gly Asp Ser Glu Thr Asp 
    50                  55                  60                  


Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn Val 
65                  70                  75                  80  


Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe Phe 
                85                  90                  95      


Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp Ala 
            100                 105                 110         


Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser Ser 
        115                 120                 125             


Pro Ala Ser Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr Pro 
    130                 135                 140                 


Thr Gly Val Val Ser Gly Pro Ala Ala Thr Pro Thr Ala Gln His Leu 
145                 150                 155                 160 


Arg Gln Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala Gly 
                165                 170                 175     


Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn His 
            180                 185                 190         


Ile Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu Ser 
        195                 200                 205             


Gln Met Asn Val Thr Ala Pro Thr Ser Pro Pro Val Gln Gln Asn Met 
    210                 215                 220                 


Met Asn Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu Gln Ala Met 
225                 230                 235                 240 


Thr Gln Asp Gly Glu Ile Tyr Tyr Ile Asn His Lys Asn Lys Thr Thr 
                245                 250                 255     


Ser Trp Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met Asn Gln Arg 
            260                 265                 270         


Ile Ser Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu Ala Pro Gln 
        275                 280                 285             


Ser Pro Gln Gly Gly Val Met Gly Gly Ser Asn Ser Asn Gln Gln Gln 
    290                 295                 300                 


Gln Met Arg Leu Gln Gln Leu Gln Met Glu Lys Glu Arg Leu Arg Leu 
305                 310                 315                 320 


Lys Gln Gln Glu Leu Leu Arg Gln Glu Leu Ala Leu Arg Ser Gln Leu 
                325                 330                 335     


Pro Thr Leu Glu Gln Asp Gly Gly Thr Gln Asn Pro Val Ser Ser Pro 
            340                 345                 350         


Gly Met Ser Gln Glu Leu Arg Thr Met Thr Thr Asn Ser Ser Asp Pro 
        355                 360                 365             


Phe Leu Asn Ser Gly Thr Tyr His Ser Arg Asp Glu Ser Thr Asp Ser 
    370                 375                 380                 


Gly Leu Ser Met Ser Ser Tyr Ser Val Pro Arg Thr Pro Asp Asp Phe 
385                 390                 395                 400 


Leu Asn Ser Val Asp Glu Met Asp Thr Gly Asp Thr Ile Asn Gln Ser 
                405                 410                 415     


Thr Leu Pro Ser Gln Gln Asn Arg Phe Pro Asp Tyr Leu Glu Ala Ile 
            420                 425                 430         


Pro Gly Thr Asn Val Asp Leu Gly Thr Leu Glu Gly Asp Gly Met Asn 
        435                 440                 445             


Ile Glu Gly Glu Glu Leu Met Pro Ser Leu Gln Glu Ala Leu Ser Ser 
    450                 455                 460                 


Asp Ile Leu Asn Asp Met Glu Ser Val Leu Ala Ala Thr Lys Leu Asp 
465                 470                 475                 480 


Lys Glu Ser Phe Leu Thr Trp Leu 
                485             


<210>  2
<211>  488
<212>  PRT
<213>  Synthetic protein

<400>  2

Met Asp Pro Gly Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Gln 
1               5                   10                  15      


Gly Gln Pro Pro Ser Gln Pro Pro Gln Gly Gln Gly Pro Pro Ser Gly 
            20                  25                  30          


Pro Gly Gln Pro Ala Pro Ala Ala Thr Gln Ala Ala Pro Gln Ala Pro 
        35                  40                  45              


Pro Ala Gly His Gln Ile Val His Val Arg Gly Asp Ala Glu Thr Asp 
    50                  55                  60                  


Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn Val 
65                  70                  75                  80  


Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe Phe 
                85                  90                  95      


Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ala Thr Asp Ala 
            100                 105                 110         


Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ala Ala 
        115                 120                 125             


Pro Ala Ala Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr Pro 
    130                 135                 140                 


Thr Gly Val Val Ser Gly Pro Ala Ala Thr Pro Thr Ala Gln His Leu 
145                 150                 155                 160 


Arg Gln Ala Ala Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala Gly 
                165                 170                 175     


Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn His 
            180                 185                 190         


Ile Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu Ser 
        195                 200                 205             


Gln Met Asn Val Thr Ala Pro Thr Ser Pro Pro Val Gln Gln Asn Met 
    210                 215                 220                 


Met Asn Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu Gln Ala Met 
225                 230                 235                 240 


Thr Gln Asp Gly Glu Ile Tyr Tyr Ile Asn His Lys Asn Lys Thr Thr 
                245                 250                 255     


Ser Trp Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met Asn Gln Arg 
            260                 265                 270         


Ile Ser Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu Ala Pro Gln 
        275                 280                 285             


Ser Pro Gln Gly Gly Val Met Gly Gly Ser Asn Ser Asn Gln Gln Gln 
    290                 295                 300                 


Gln Met Arg Leu Gln Gln Leu Gln Met Glu Lys Glu Arg Leu Arg Leu 
305                 310                 315                 320 


Lys Gln Gln Glu Leu Leu Arg Gln Glu Leu Ala Leu Arg Ser Gln Leu 
                325                 330                 335     


Pro Thr Leu Glu Gln Asp Gly Gly Thr Gln Asn Pro Val Ser Ser Pro 
            340                 345                 350         


Gly Met Ser Gln Glu Leu Arg Thr Met Thr Thr Asn Ser Ser Asp Pro 
        355                 360                 365             


Phe Leu Asn Ser Gly Thr Tyr His Ser Arg Asp Glu Ala Thr Asp Ser 
    370                 375                 380                 


Gly Leu Ser Met Ser Ser Tyr Ser Val Pro Arg Thr Pro Asp Asp Phe 
385                 390                 395                 400 


Leu Asn Ser Val Asp Glu Met Asp Thr Gly Asp Thr Ile Asn Gln Ser 
                405                 410                 415     


Thr Leu Pro Ser Gln Gln Asn Arg Phe Pro Asp Tyr Leu Glu Ala Ile 
            420                 425                 430         


Pro Gly Thr Asn Val Asp Leu Gly Thr Leu Glu Gly Asp Gly Met Asn 
        435                 440                 445             


Ile Glu Gly Glu Glu Leu Met Pro Ser Leu Gln Glu Ala Leu Ser Ser 
    450                 455                 460                 


Asp Ile Leu Asn Asp Met Glu Ser Val Leu Ala Ala Thr Lys Leu Asp 
465                 470                 475                 480 


Lys Glu Ser Phe Leu Thr Trp Leu 
                485             


<210>  3
<211>  523
<212>  PRT
<213>  Synthetic protein

<400>  3

Met Asp Tyr Lys Asp Asp Asp Asp Lys Leu Ala Ala Ala Asn Ser Ser 
1               5                   10                  15      


Leu Ala Thr Met Asp Tyr Lys Asp Asp Asp Asp Lys Ala Arg Leu Glu 
            20                  25                  30          


Ser Val Pro Lys Asp Pro Gly Gln Gln Pro Pro Pro Gln Pro Ala Pro 
        35                  40                  45              


Gln Gly Gln Gly Gln Pro Pro Ser Gln Pro Pro Gln Gly Gln Gly Pro 
    50                  55                  60                  


Pro Ser Gly Pro Gly Gln Pro Ala Pro Ala Ala Thr Gln Ala Ala Pro 
65                  70                  75                  80  


Gln Ala Pro Pro Ala Gly His Gln Ile Val His Val Arg Gly Asp Ala 
                85                  90                  95      


Glu Thr Asp Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr 
            100                 105                 110         


Ala Asn Val Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp 
        115                 120                 125             


Ser Phe Phe Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ala 
    130                 135                 140                 


Thr Asp Ala Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala 
145                 150                 155                 160 


His Ala Ala Pro Ala Ala Leu Gln Leu Gly Ala Val Ser Pro Gly Thr 
                165                 170                 175     


Leu Thr Pro Thr Gly Val Val Ser Gly Pro Ala Ala Thr Pro Thr Ala 
            180                 185                 190         


Gln His Leu Arg Gln Ala Ala Phe Glu Ile Pro Asp Asp Val Pro Leu 
        195                 200                 205             


Pro Ala Gly Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe 
    210                 215                 220                 


Leu Asn His Ile Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala 
225                 230                 235                 240 


Met Leu Ser Gln Met Asn Val Thr Ala Pro Thr Ser Pro Pro Val Gln 
                245                 250                 255     


Gln Asn Met Met Asn Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu 
            260                 265                 270         


Gln Ala Met Thr Gln Asp Gly Glu Ile Tyr Tyr Ile Asn His Lys Asn 
        275                 280                 285             


Lys Thr Thr Ser Trp Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met 
    290                 295                 300                 


Asn Gln Arg Ile Ser Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu 
305                 310                 315                 320 


Ala Pro Gln Ser Pro Gln Gly Gly Val Met Gly Gly Ser Asn Ser Asn 
                325                 330                 335     


Gln Gln Gln Gln Met Arg Leu Gln Gln Leu Gln Met Glu Lys Glu Arg 
            340                 345                 350         


Leu Arg Leu Lys Gln Gln Glu Leu Leu Arg Gln Glu Leu Ala Leu Arg 
        355                 360                 365             


Ser Gln Leu Pro Thr Leu Glu Gln Asp Gly Gly Thr Gln Asn Pro Val 
    370                 375                 380                 


Ser Ser Pro Gly Met Ser Gln Glu Leu Arg Thr Met Thr Thr Asn Ser 
385                 390                 395                 400 


Ser Asp Pro Phe Leu Asn Ser Gly Thr Tyr His Ser Arg Asp Glu Ala 
                405                 410                 415     


Thr Asp Ser Gly Leu Ser Met Ser Ser Tyr Ser Val Pro Arg Thr Pro 
            420                 425                 430         


Asp Asp Phe Leu Asn Ser Val Asp Glu Met Asp Thr Gly Asp Thr Ile 
        435                 440                 445             


Asn Gln Ser Thr Leu Pro Ser Gln Gln Asn Arg Phe Pro Asp Tyr Leu 
    450                 455                 460                 


Glu Ala Ile Pro Gly Thr Asn Val Asp Leu Gly Thr Leu Glu Gly Asp 
465                 470                 475                 480 


Gly Met Asn Ile Glu Gly Glu Glu Leu Met Pro Ser Leu Gln Glu Ala 
                485                 490                 495     


Leu Ser Ser Asp Ile Leu Asn Asp Met Glu Ser Val Leu Ala Ala Thr 
            500                 505                 510         


Lys Leu Asp Lys Glu Ser Phe Leu Thr Trp Leu 
        515                 520             


<210>  4
<211>  1572
<212>  DNA
<213>  Synthetic DNA

<400>  4
atggactaca aagacgatga cgacaagctt gcggccgcga attcaagctt agccaccatg       60

gactacaaag acgatgacga taaagcaagg ctcgaatcgg tacctaagga tcccgggcag      120

cagccgccgc ctcaaccggc cccccagggc caagggcagc cgccttcgca gcccccgcag      180

gggcagggcc cgccgtccgg acccgggcaa ccggcacccg cggcgaccca ggcggcgccg      240

caggcacccc ccgccgggca tcagatcgtg cacgtccgcg gggacgcgga gaccgacctg      300

gaggcgctct tcaacgccgt catgaacccc aagacggcca acgtgcccca gaccgtgccc      360

atgaggctcc ggaagctgcc cgactccttc ttcaagccgc cggagcccaa atcccactcc      420

cgacaggccg ctactgatgc aggcactgca ggagccctga ctccacagca tgttcgagct      480

catgccgctc cagctgctct gcagttggga gctgtttctc ctgggacact gacccccact      540

ggagtagtct ctggcccagc agctacaccc acagctcagc atcttcgaca ggctgctttt      600

gagatacctg atgatgtacc tctgccagca ggttgggaga tggcaaagac atcttctggt      660

cagagatact tcttaaatca catcgatcag acaacaacat ggcaggaccc caggaaggcc      720

atgctgtccc agatgaacgt cacagccccc accagtccac cagtgcagca gaatatgatg      780

aactcggctt caggtcctct tcctgatgga tgggaacaag ccatgactca ggatggagaa      840

atttactata taaaccataa gaacaagacc acctcttggc tagacccaag gcttgaccct      900

cgttttgcca tgaaccagag aatcagtcag agtgctccag tgaaacagcc accacccctg      960

gctccccaga gcccacaggg aggcgtcatg ggtggcagca actccaacca gcagcaacag     1020

atgcgactgc agcaactgca gatggagaag gagaggctgc ggctgaaaca gcaagaactg     1080

cttcggcagg agttagccct gcgtagccag ttaccaacac tggagcagga tggtgggact     1140

caaaatccag tgtcttctcc cgggatgtct caggaattga gaacaatgac gaccaatagc     1200

tcagatcctt tccttaacag tggcacctat cactctcgag atgaggctac agacagtgga     1260

ctaagcatga gcagctacag tgtccctcga accccagatg acttcctgaa cagtgtggat     1320

gagatggata caggtgatac tatcaaccaa agcaccctgc cctcacagca gaaccgtttc     1380

ccagactacc ttgaagccat tcctgggaca aatgtggacc ttggaacact ggaaggagat     1440

ggaatgaaca tagaaggaga ggagctgatg ccaagtctgc aggaagcttt gagttctgac     1500

atccttaatg acatggagtc tgttttggct gccaccaagc tagataaaga aagctttctt     1560

acatggttat ag                                                         1572


<210>  5
<211>  20
<212>  PRT
<213>  Synthetic primer

<400>  5

Ala Ala Gly Cys Cys Thr Thr Gly Ala Cys Thr Thr Gly Ala Gly Gly 
1               5                   10                  15      


Thr Thr Ala Gly 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  Synthetic primer

<400>  6

Cys Gly Thr Cys Ala Thr Cys Gly Thr Cys Thr Thr Thr Gly Thr Ala 
1               5                   10                  15      


Gly Thr Cys Cys 
            20  


