
                                SEQUENCE LISTING

<110> Seattle Children's Hospital
      dba Seattle Children's Research Institute
      Rawlings, David J.
      James, Richard
      Jackson, Shaun W.
      Khan, Iram
      Hung, King

<120> ENGRAFTABLE CELL-BASED IMMUNOTHERAPY FOR
  LONG-TERM DELIVERY OF THERAPEUTIC PROTEINS
  

<130> SCRI.133WO

<150> 62/571918           
<151> 2017-10-13  

<150> 62/549385           
<151> 2017-08-23  

<150> 62/472493           
<151> 2017-03-16  

<160> 113

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> tracrRNA recognition sequence

<400> 1
guuuuagagc uaugcu                                                 16

<210> 2
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> PAX5

<400> 2
ugugaaugga cggccacucc                                             20

<210> 3
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> PAX5

<400> 3
uguaguccgc cagaggauag                                             20

<210> 4
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> IRF8

<400> 4
auugacagua gcauguaucc                                             20

<210> 5
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> IRF8

<400> 5
cggaaauguc caguugggac                                             20

<210> 6
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BACH2

<400> 6
guuccugcgc augcacaacc                                             20

<210> 7
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BACH2

<400> 7
cugugacgug acuuugaucg                                             20

<210> 8
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> CCR5

<400> 8
caauguguca acucuugaca                                             20

<210> 9
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> CCR5

<400> 9
gcuguguuug cgucucuccc                                             20

<210> 10
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> CARD11

<400> 10
caaugaccuu acacugacgc                                             20

<210> 11
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> PRDM1

<400> 11
ugauggcggu acuucgguuc                                             20

<210> 12
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> PRDM1

<400> 12
aggaugcgga uaugacucug                                             20

<210> 13
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> PRDM1

<400> 13
ggggagcgag ugauguacgu                                             20

<210> 14
<211> 4875
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1079_pscAAV-MND.GFP AAV repair template

<400> 14
aagcttcccg gggggatctg ggccactccc tctctgcgcg ctcgctcgct cactgaggcc 60
gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga 120
gcgcgcagag agggagtggc caactccatc actaggggtt cctggagggg tggagtcgtg 180
acctagggaa cagagaaaca ggagaatatg ggccaaacag gatatctgtg gtaagcagtt 240
cctgccccgg ctcagggcca agaacagttg gaacagcaga atatgggcca aacaggatat 300
ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc cagatgcggt 360
cccgccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc aaggacctga 420
aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg 480
cttctgctcc ccgagctcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 540
agacgccatc cacgctgttt tgacttccat agaaggatcc tcgaggccac catggtgagc 600
aagggcgagg agctgttcac cggggtggtg cccatcctgg tcgagctgga cggcgacgta 660
aacggccaca agttcagcgt gtccggcgag ggcgagggcg atgccaccta cggcaagctg 720
accctgaagt tcatctgcac caccggcaag ctgcccgtgc cctggcccac cctcgtgacc 780
accctgacct acggcgtgca gtgcttcagc cgctaccccg accacatgaa gcagcacgac 840
ttcttcaagt ccgccatgcc cgaaggctac gtccaggagc gcaccatctt cttcaaggac 900
gacggcaact acaagacccg cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc 960
atcgagctga agggcatcga cttcaaggag gacggcaaca tcctggggca caagctggag 1020
tacaactaca acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag 1080
gtgaacttca agatccgcca caacatcgag gacggcagcg tgcagctcgc cgaccactac 1140
cagcagaaca cccccatcgg cgacggcccc gtgctgctgc ccgacaacca ctacctgagc 1200
acccagtccg ccctgagcaa agaccccaac gagaagcgcg atcacatggt cctgctggag 1260
ttcgtgaccg ccgccgggat cactctcggc atggacgagc tgtacaagta agcggccgca 1320
attcacccca ccagtgcagg ctgcctatca gaaagtggtg gctggtgtgg ctaatgccct 1380
ggcccacaag tatcactaag ctcgctttct tgctgtccaa tttctattaa aggttccttt 1440
gttccctaag tccaactact aaactggggg atattatgaa gggccttgag catctggatt 1500
ctgcctaata aaaaacattt attttcattg caatgatgta tttaaattat ttctgaatat 1560
tttactaaaa agggaatgtg ggaggtcagt gcatttaaaa cataaagaaa tgaagagcta 1620
gttcaaacct tgggaaaata cactatatct taaactccat gaaagaaggt gaggctgcaa 1680
acagctaatg cacattggca acagcccctg atgcctatgc cttattcatc cctcagaaaa 1740
ggattcaagt agaggcttga tttggaggtt aaagttttgc tatgctgtat tttacattac 1800
ttattgtttt agctgtcctc atgaatgtct tttcactacc catttgctta tcctgcatct 1860
ctcagccttg actccactca gttctcttgc ttagagatac cacctttccc ctgaagtgtt 1920
ccttccatgt tttacggcga gatggtttct cctcgcctgg ccactcagcc ttagttgtct 1980
ctgttgtctt atagaggtct acttgaagaa ggaaaaacag ggggcatggt ttgactgtcc 2040
tgtgagccct tcttccctgc ctcccccact cacagtgaca ctagtccact ccctctctgc 2100
gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc 2160
gggcggcctc agtgagcgag cgagcgcgca gagagggaca gatccgggcc cgcatgcgtc 2220
gacaattcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa 2280
cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc 2340
accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggcgcct gatgcggtat 2400
tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct cagtacaatc 2460
tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc 2520
tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc 2580
tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg 2640
atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc 2700
acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat 2760
atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag 2820
agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt 2880
cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt 2940
gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc 3000
cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta 3060
tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac 3120
ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa 3180
ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg 3240
atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc 3300
cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg 3360
atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta 3420
gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg 3480
cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg 3540
tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc 3600
tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt 3660
gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt 3720
gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc 3780
atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag 3840
atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa 3900
aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg 3960
aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt gtagccgtag 4020
ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg 4080
ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga 4140
tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc 4200
ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc 4260
acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga 4320
gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt 4380
cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg 4440
aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac 4500
atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga 4560
gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg 4620
gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatgcagc 4680
tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt 4740
tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg tatgttgtgt 4800
ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga ttacgccaag 4860
ctctcgagat ctaga                                                  4875

<210> 15
<211> 5056
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1347_pscAAV.Blimp.0.4kb.MND.GFP AAV repair
      template

<400> 15
aagcttcccg gggggatctg ggccactccc tctctgcgcg ctcgctcgct cactgaggcc 60
gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga 120
gcgcgcagag agggagtggc caactccatc actaggggtt cctggagggg tggagtcgtg 180
acctaggacg cgtgccagct gttactcagg ttttctcaag aaggaggagc aactttggca 240
gttttgcttc agttctctct agccctctgt gtaatcgccc ctttttcttt atttcagcac 300
aaacacagag cagtctaaag caaccgagca ctgagaaaaa tgaactctgc ccaaagaatg 360
tcccaaagag agagtacagc gtgaaagaaa tcctaaaatt ggactccaac ccctccaaag 420
gaaaggacct ctaccgttct aacatttcac ccctcacatc agaaaaggac ctcgatgact 480
ttagaagacg tgggagcccc gaaatgccct tctaccctcg ggtcgtttac cccatccggg 540
cccctctgcc agaagacttt ttgaaagctt ccctggccta cgggatcgag agagaacaga 600
gaaacaggag aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca 660
gggccaagaa cagttggaac agcagaatat gggccaaaca ggatatctgt ggtaagcagt 720
tcctgccccg gctcagggcc aagaacagat ggtccccaga tgcggtcccg ccctcagcag 780
tttctagaga accatcagat gtttccaggg tgccccaagg acctgaaatg accctgtgcc 840
ttatttgaac taaccaatca gttcgcttct cgcttctgtt cgcgcgcttc tgctccccga 900
gctctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagac gccatccacg 960
ctgttttgac ttccatagaa ggatctcgag gccaccatgg tgagcaaggg cgaggagctg 1020
ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc 1080
agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc 1140
tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc 1200
gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc 1260
atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag 1320
acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc 1380
atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc 1440
cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc 1500
cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc 1560
atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg 1620
agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc 1680
gggatcactc tcggcatgga cgagctgtac aagtaaacta gtgtcgactg ctttatttgt 1740
gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac 1800
aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa 1860
aacgtacatc actcgctccc ccattccatc ctccaccact ccaagcccct ctgcaagaag 1920
cagccccgac caaagcctca agagctccag ccctcacagc agccctggga atacggtgtc 1980
ccctgtgggc cccggctctc aagagcaccg ggactcctac gcttacttga acgcgtccta 2040
cggcacggaa ggtttgggct cctaccctgg ctacgcaccc ctgccccacc tcccgccagc 2100
tttcatcccc tcgtacaacg ctcactaccc caagttcctc ttgcccccct acggcatgaa 2160
ttgtaatggc ctgagcgctg tgagcagcat gaatggcatc aacaactttg gcctcttccc 2220
gaggctgtgc cctgtctaca gcaatctcct cggtgggggc actagtccac tccctctctg 2280
cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc 2340
cgggcggcct cagtgagcga gcgagcgcgc agagagggac agatccgggc ccgcatgcgt 2400
cgacaattca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca 2460
acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg 2520
caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgcc tgatgcggta 2580
ttttctcctt acgcatctgt gcggtatttc acaccgcata tggtgcactc tcagtacaat 2640
ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc 2700
ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag 2760
ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt 2820
gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg 2880
cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa 2940
tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa 3000
gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct 3060
tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg 3120
tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg 3180
ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt 3240
atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga 3300
cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga 3360
attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac 3420
gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg 3480
ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac 3540
gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct 3600
agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct 3660
gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg 3720
gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat 3780
ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg 3840
tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat 3900
tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct 3960
catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa 4020
gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa 4080
aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc 4140
gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta 4200
gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct 4260
gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg 4320
atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag 4380
cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc 4440
cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg 4500
agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt 4560
tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg 4620
gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca 4680
catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg 4740
agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc 4800
ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag 4860
ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag 4920
ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg 4980
tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa 5040
gctctcgaga tctaga                                                 5056



<210> 16
<211> 6006
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1348_pAAV.Blimp.0.4kb.MND.GFP.pA AAV repair
      template

<400> 16
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtgcca 180
gctgttactc aggttttctc aagaaggagg agcaactttg gcagttttgc ttcagttctc 240
tctagccctc tgtgtaatcg cccctttttc tttatttcag cacaaacaca gagcagtcta 300
aagcaaccga gcactgagaa aaatgaactc tgcccaaaga atgtcccaaa gagagagtac 360
agcgtgaaag aaatcctaaa attggactcc aacccctcca aaggaaagga cctctaccgt 420
tctaacattt cacccctcac atcagaaaag gacctcgatg actttagaag acgtgggagc 480
cccgaaatgc ccttctaccc tcgggtcgtt taccccatcc gggcccctct gccagaagac 540
tttttgaaag cttccctggc ctacgggatc gagagagaac agagaaacag gagaatatgg 600
gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa gaacagttgg 660
aacagcagaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc ccggctcagg 720
gccaagaaca gatggtcccc agatgcggtc ccgccctcag cagtttctag agaaccatca 780
gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg aactaaccaa 840
tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctctat ataagcagag 900
ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacttccata 960
gaaggatctc gaggccacca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc 1020
catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg 1080
cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct 1140
gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg 1200
ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt 1260
ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa 1320
gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga 1380
cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat 1440
ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga 1500
cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt 1560
gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga 1620
gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat 1680
ggacgagctg tacaagtaaa ctagtgtcga ctgctttatt tgtgaaattt gtgatgctat 1740
tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca 1800
ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaaacgtac atcactcgct 1860
cccccattcc atcctccacc actccaagcc cctctgcaag aagcagcccc gaccaaagcc 1920
tcaagagctc cagccctcac agcagccctg ggaatacggt gtcccctgtg ggccccggct 1980
ctcaagagca ccgggactcc tacgcttact tgaacgcgtc ctacggcacg gaaggtttgg 2040
gctcctaccc tggctacgca cccctgcccc acctcccgcc agctttcatc ccctcgtaca 2100
acgctcacta ccccaagttc ctcttgcccc cctacggcat gaattgtaat ggcctgagcg 2160
ctgtgagcag catgaatggc atcaacaact ttggcctctt cccgaggctg tgccctgtct 2220
acagcaatct cctcggtggg ggcatctaga gtagataagt agcatggcgg gttaatcatt 2280
aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc 2340
actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg 2400
agcgagcgag cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca 2460
acagttgcgc agcctgaatg gcgaatggcg attccgttgc aatggctggc ggtaatattg 2520
ttctggatat taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta 2580
ttactaatca aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac 2640
tcggtggcct cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta 2700
aaatcccttt aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt 2760
tatacgtgct cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg 2820
ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct 2880
ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat 2940
cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt 3000
gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg 3060
acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac 3120
cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta 3180
aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca 3240
atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg 3300
gtacatatga ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc 3360
agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct 3420
ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct 3480
ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa 3540
tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag 3600
tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat 3660
tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct 3720
gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct 3780
cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc 3840
tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt 3900
ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa 3960
gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac 4020
gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat 4080
acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg 4140
aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc 4200
attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga 4260
tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga 4320
gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg 4380
cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc 4440
tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac 4500
agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact 4560
tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca 4620
tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg 4680
tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact 4740
acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg 4800
accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg 4860
tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat 4920
cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc 4980
tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat 5040
actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt 5100
tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc 5160
cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt 5220
gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac 5280
tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt 5340
gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct 5400
gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga 5460
ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac 5520
acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg 5580
agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt 5640
cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc 5700
tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg 5760
gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc 5820
ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc 5880
ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag 5940
cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca 6000
ttaatg                                                            6006



<210> 17
<211> 7206
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1361_pAAV.Blimp1.1.0kb.MND.GFP.pA AAV repair
      template

<400> 17
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtggta 180
aaccatgaac atcagaaaga cttttattaa cctatgacag ggtccccacc ccagtatttt 240
tccactccat taaaatggaa gttttttttt tttttttctt ttttgagaca gagttttgct 300
cttgttgccc agtctggagt gcaatggcac aatctcggct caccacaacc tccacctccc 360
agattcaagc gattcttctg cctcagcctc ccaagtagct gggattacag gtgtgcgcca 420
ccacgcccag ctaattttgt atttttagta gagatggggt ttctccatgt tggtcaggct 480
ggtctcgaac ttccgacctc aggtgatccg cccacctcgg cctcccaaag tgctgggatt 540
acaggcaaga gccactgcat ccagcttagg ctatcttact ccagcctaaa cagcaatttt 600
ctatcataag gtctgtacta atgaaaacag aatcacccaa ggctgctgtt tgttctgtct 660
gtgctgccat tgtccgcatt ttgctgagga ggaaacggaa ctgcactttt gagtgagtgg 720
cccagagcct tctagaatga gagtgcgttg gaagccagat atgtggcgat tgtgtcgcca 780
gctgttactc aggttttctc aagaaggagg agcaactttg gcagttttgc ttcagttctc 840
tctagccctc tgtgtaatcg cccctttttc tttatttcag cacaaacaca gagcagtcta 900
aagcaaccga gcactgagaa aaatgaactc tgcccaaaga atgtcccaaa gagagagtac 960
agcgtgaaag aaatcctaaa attggactcc aacccctcca aaggaaagga cctctaccgt 1020
tctaacattt cacccctcac atcagaaaag gacctcgatg actttagaag acgtgggagc 1080
cccgaaatgc ccttctaccc tcgggtcgtt taccccatcc gggcccctct gccagaagac 1140
tttttgaaag cttccctggc ctacgggatc gagagagaac agagaaacag gagaatatgg 1200
gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa gaacagttgg 1260
aacagcagaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc ccggctcagg 1320
gccaagaaca gatggtcccc agatgcggtc ccgccctcag cagtttctag agaaccatca 1380
gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg aactaaccaa 1440
tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctctat ataagcagag 1500
ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacttccata 1560
gaaggatctc gaggccacca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc 1620
catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg 1680
cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct 1740
gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg 1800
ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt 1860
ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa 1920
gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga 1980
cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat 2040
ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga 2100
cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt 2160
gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga 2220
gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat 2280
ggacgagctg tacaagtaaa ctagtgtcga ctgctttatt tgtgaaattt gtgatgctat 2340
tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca 2400
ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaaacgtac atcactcgct 2460
cccccattcc atcctccacc actccaagcc cctctgcaag aagcagcccc gaccaaagcc 2520
tcaagagctc cagccctcac agcagccctg ggaatacggt gtcccctgtg ggccccggct 2580
ctcaagagca ccgggactcc tacgcttact tgaacgcgtc ctacggcacg gaaggtttgg 2640
gctcctaccc tggctacgca cccctgcccc acctcccgcc agctttcatc ccctcgtaca 2700
acgctcacta ccccaagttc ctcttgcccc cctacggcat gaattgtaat ggcctgagcg 2760
ctgtgagcag catgaatggc atcaacaact ttggcctctt cccgaggctg tgccctgtct 2820
acagcaatct cctcggtggg ggcagcctgc cccaccccat gctcaacccc acttctctcc 2880
cgagctcgct gccctcagat ggagcccgga ggttgctcca gccggagcat cccagggagg 2940
tgcttgtccc ggcgccccac agtgccttct cctttaccgg ggccgccgcc agcatgaagg 3000
acaaggcctg tagccccaca agcgggtctc ccacggcggg aacagccgcc acggcagaac 3060
atgtggtgca gcccaaagct acctcagcag cgatggcagc ccccagcagc gacgaagcca 3120
tgaatctcat taaaaacaaa agaaacatga ccggctacaa gacccttccc tacccgctga 3180
agaagcagaa cggcaagatc aagtacgaat gcaacgtttg cgccaagact ttcggccagc 3240
tctccaatct gaaggtaggc cttgagagag agcagtccaa ggggctgtga gtgcatgctt 3300
gtgtttgtat ttagcttgct ttccatgggg tatcgattgc atttgcagta gtatgagccc 3360
ccggttgggg atagtgggta tggattccgc ctggcttttg ccacttctag ctctttgact 3420
ttggacaagt gacttccctt ctcctctaga gtagataagt agcatggcgg gttaatcatt 3480
aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc 3540
actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg 3600
agcgagcgag cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca 3660
acagttgcgc agcctgaatg gcgaatggcg attccgttgc aatggctggc ggtaatattg 3720
ttctggatat taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta 3780
ttactaatca aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac 3840
tcggtggcct cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta 3900
aaatcccttt aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt 3960
tatacgtgct cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg 4020
ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct 4080
ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat 4140
cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt 4200
gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg 4260
acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac 4320
cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta 4380
aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca 4440
atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg 4500
gtacatatga ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc 4560
agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct 4620
ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct 4680
ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa 4740
tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag 4800
tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat 4860
tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct 4920
gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct 4980
cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc 5040
tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt 5100
ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa 5160
gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac 5220
gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat 5280
acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg 5340
aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc 5400
attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga 5460
tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga 5520
gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg 5580
cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc 5640
tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac 5700
agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact 5760
tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca 5820
tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg 5880
tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact 5940
acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg 6000
accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg 6060
tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat 6120
cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc 6180
tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat 6240
actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt 6300
tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc 6360
cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt 6420
gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac 6480
tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt 6540
gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct 6600
gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga 6660
ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac 6720
acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg 6780
agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt 6840
cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc 6900
tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg 6960
gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc 7020
ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc 7080
ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag 7140
cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca 7200
ttaatg                                                            7206



<210> 18
<211> 6707
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1366_CCR5.MND.BAFF_CRISPR.HR AAV repair template

<400> 18
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tttggtgtgg tggcgcctgt agtccccagc cacttggagg ggtgaggtga gaggattgct 300
tgagcccggg atggtccagg ctgcagtgag ccatgatcgt gccactgcac tccagcctgg 360
gcgacagagt gagaccctgt ctcacaacaa caacaacaac aacaaaaagg ctgagctgca 420
ccatgcttga cccagtttct taaaattgtt gtcaaagctt cattcactcc atggtgctat 480
agagcacaag attttatttg gtgagatggt gctttcatga attcccccaa cagagccaag 540
ctctccatct agtggacagg gaagctagca gcaaaccttc ccttcactac aaaacttcat 600
tgcttggcca aaaagagagt taattcaatg tagacatcta tgtaggcaat taaaaaccta 660
ttgatgtata aaacagtttg cattcatgga gggcaactaa atacattcta ggactttata 720
aaagatcact ttttatttat gcacagggtg gaacaagatg gattatcaag tgtcaagtcc 780
aatctatgac atcaattatt atacatcgga gccctgccaa aaaatcaatg tgaagcaaat 840
cgcagcccgc ctcctgcctc cgctctactc actggtgttc atctttggtt ttgtgggcaa 900
catgctggtc atcctcatcc tgataaactg caaaaggctg aagagcatga ctgacatcta 960
cctgctcaac ctggccatct ctgacctgtt tttccttctt actgtcccct tctgggctca 1020
ctatgctgcc gcccagtggg actttggaaa tacaatgtgt caacgaacag agaaacagga 1080
gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga 1140
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc 1200
ggctcagggc caagaacaga tggtccccag atgcggtccc gccctcagca gtttctagag 1260
aaccatcaga tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa 1320
ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctctatat 1380
aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 1440
cttccataga aggatctcga ggccaccatg taccggatgc agctgctgag ctgcatcgca 1500
ctgagcctgg cactggtgac caacagcgca gtgcagggac cagaggagac cgtgacccag 1560
gactgcctgc agctgatcgc agacagcgag acccccacca tccagaaggg cagctacacc 1620
ttcgtgccct ggctgctgag cttcaagcgg ggcagcgccc tggaggagaa ggagaacaag 1680
attctggtga aggagaccgg ctacttcttc atctacggcc aggtgctgta caccgataag 1740
acctacgcca tgggccacct gatccagcgg aagaaggtgc acgtgttcgg cgacgagctg 1800
agcctggtga ccctgttccg gtgcatccag aacatgcccg agaccctgcc caacaacagc 1860
tgctacagcg caggaatcgc aaagctggag gagggcgacg agctgcagct ggcaatcccc 1920
cgggagaacg cacagatcag cctggacggc gacgtgacct tcttcggcgc cctgaagctc 1980
ctgtgagtcg actgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt 2040
ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag 2100
ggggaggtgt gggaggtttt ttaaactcta ttttataggc ttcttctctg gaatcttctt 2160
catcatcctc ctgacaatcg ataggtacct ggctgtcgtc catgctgtgt ttgctttaaa 2220
agccaggacg gtcacctttg gggtggtgac aagtgtgatc acttgggtgg tggctgtgtt 2280
tgcgtctctc ccaggaatca tctttaccag atctcaaaaa gaaggtcttc attacacctg 2340
cagctctcat tttccataca gtcagtatca attctggaag aatttccaga cattaaagat 2400
agtcatcttg gggctggtcc tgccgctgct tgtcatggtc atctgctact cgggaatcct 2460
aaaaactctg cttcggtgtc gaaatgagaa gaagaggcac agggctgtga ggcttatctt 2520
caccatcatg attgtttatt ttctcttctg ggctccctac aacattgtcc ttctcctgaa 2580
caccttccag gaattctttg gcctgaataa ttgcagtagc tctaacaggt tggaccaagc 2640
tatgcaggtg acagagactc ttgggatgac gcactgctgc atcaacccca tcatctatgc 2700
ctttgtcggg gagaagttca gaaactacct cttagtcttc ttccaaaagc acattgccaa 2760
acgcttctgc aaatgctgtt ctattttcca gcaagaggct cccgagcgag caagctcagt 2820
ttacacccga tccactgggg agcaggaaat atctgtgggc ttgtgacacg gactcaagtg 2880
ggctggtgac ccagtcagag ttgtgcacat ggcttagttt tcatacacac cgcggtctag 2940
agcatggcta cgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag 3000
tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa 3060
aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgccagc 3120
tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat 3180
ggcgaatggc gattccgttg caatggctgg cggtaatatt gttctggata ttaccagcaa 3240
ggccgatagt ttgagttctt ctactcaggc aagtgatgtt attactaatc aaagaagtat 3300
tgcgacaacg gttaatttgc gtgatggaca gactctttta ctcggtggcc tcactgatta 3360
taaaaacact tctcaggatt ctggcgtacc gttcctgtct aaaatccctt taatcggcct 3420
cctgtttagc tcccgctctg attctaacga ggaaagcacg ttatacgtgc tcgtcaaagc 3480
aaccatagta cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca 3540
gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct 3600
ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt 3660
tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac 3720
gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct 3780
ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt 3840
ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac 3900
aaaaatttaa cgcgaatttt aacaaaatat taacgtttac aatttaaata tttgcttata 3960
caatcttcct gtttttgggg cttttctgat tatcaaccgg ggtacatatg attgacatgc 4020
tagttttacg attaccgttc atcgattctc ttgtttgctc cagactctca ggcaatgacc 4080
tgatagcctt tgtagagacc tctcaaaaat agctaccctc tccggcatga atttatcagc 4140
tagaacggtt gaatatcata ttgatggtga tttgactgtc tccggccttt ctcacccgtt 4200
tgaatcttta cctacacatt actcaggcat tgcatttaaa atatatgagg gttctaaaaa 4260
tttttatcct tgcgttgaaa taaaggcttc tcccgcaaaa gtattacagg gtcataatgt 4320
ttttggtaca accgatttag ctttatgctc tgaggcttta ttgcttaatt ttgctaattc 4380
tttgccttgc ctgtatgatt tattggatgt tggaatcgcc tgatgcggta ttttctcctt 4440
acgcatctgt gcggtatttc acaccgcata tggtgcactc tcagtacaat ctgctctgat 4500
gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct 4560
tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt 4620
cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta 4680
tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg 4740
ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg 4800
ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt 4860
attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt 4920
gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg 4980
ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa 5040
cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt 5100
gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag 5160
tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt 5220
gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga 5280
ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt 5340
tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta 5400
gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg 5460
caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc 5520
cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt 5580
atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg 5640
gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg 5700
attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa 5760
cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa 5820
atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga 5880
tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg 5940
ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact 6000
ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac 6060
cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg 6120
gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg 6180
gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga 6240
acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc 6300
gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg 6360
agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc 6420
tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc 6480
agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt 6540
cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc 6600
gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc 6660
ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatg               6707



<210> 19
<211> 7494
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1367_CCR5.MND.BAFF.2A.GFP AAV repair template

<400> 19
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tttggtgtgg tggcgcctgt agtccccagc cacttggagg ggtgaggtga gaggattgct 300
tgagcccggg atggtccagg ctgcagtgag ccatgatcgt gccactgcac tccagcctgg 360
gcgacagagt gagaccctgt ctcacaacaa caacaacaac aacaaaaagg ctgagctgca 420
ccatgcttga cccagtttct taaaattgtt gtcaaagctt cattcactcc atggtgctat 480
agagcacaag attttatttg gtgagatggt gctttcatga attcccccaa cagagccaag 540
ctctccatct agtggacagg gaagctagca gcaaaccttc ccttcactac aaaacttcat 600
tgcttggcca aaaagagagt taattcaatg tagacatcta tgtaggcaat taaaaaccta 660
ttgatgtata aaacagtttg cattcatgga gggcaactaa atacattcta ggactttata 720
aaagatcact ttttatttat gcacagggtg gaacaagatg gattatcaag tgtcaagtcc 780
aatctatgac atcaattatt atacatcgga gccctgccaa aaaatcaatg tgaagcaaat 840
cgcagcccgc ctcctgcctc cgctctactc actggtgttc atctttggtt ttgtgggcaa 900
catgctggtc atcctcatcc tgataaactg caaaaggctg aagagcatga ctgacatcta 960
cctgctcaac ctggccatct ctgacctgtt tttccttctt actgtcccct tctgggctca 1020
ctatgctgcc gcccagtggg actttggaaa tacaatgtgt caacgaacag agaaacagga 1080
gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga 1140
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc 1200
ggctcagggc caagaacaga tggtccccag atgcggtccc gccctcagca gtttctagag 1260
aaccatcaga tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa 1320
ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctctatat 1380
aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 1440
cttccataga aggatctcga ggccaccatg taccggatgc agctgctgag ctgcatcgca 1500
ctgagcctgg cactggtgac caacagcgca gtgcagggac cagaggagac cgtgacccag 1560
gactgcctgc agctgatcgc agacagcgag acccccacca tccagaaggg cagctacacc 1620
ttcgtgccct ggctgctgag cttcaagcgg ggcagcgccc tggaggagaa ggagaacaag 1680
attctggtga aggagaccgg ctacttcttc atctacggcc aggtgctgta caccgataag 1740
acctacgcca tgggccacct gatccagcgg aagaaggtgc acgtgttcgg cgacgagctg 1800
agcctggtga ccctgttccg gtgcatccag aacatgcccg agaccctgcc caacaacagc 1860
tgctacagcg caggaatcgc aaagctggag gagggcgacg agctgcagct ggcaatcccc 1920
cgggagaacg cacagatcag cctggacggc gacgtgacct tcttcggcgc cctgaagctc 1980
ctgggatccg gtgagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccg 2040
ggccccatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag 2100
ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc 2160
acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg 2220
cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac 2280
atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc 2340
atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac 2400
accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg 2460
gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag 2520
aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag 2580
ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac 2640
aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac 2700
atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac 2760
aagtgaatct agagtcgact gctttatttg tgaaatttgt gatgctattg ctttatttgt 2820
aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca 2880
ggttcagggg gaggtgtggg aggtttttta aactctattt tataggcttc ttctctggaa 2940
tcttcttcat catcctcctg acaatcgata ggtacctggc tgtcgtccat gctgtgtttg 3000
ctttaaaagc caggacggtc acctttgggg tggtgacaag tgtgatcact tgggtggtgg 3060
ctgtgtttgc gtctctccca ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt 3120
acacctgcag ctctcatttt ccatacagtc agtatcaatt ctggaagaat ttccagacat 3180
taaagatagt catcttgggg ctggtcctgc cgctgcttgt catggtcatc tgctactcgg 3240
gaatcctaaa aactctgctt cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc 3300
ttatcttcac catcatgatt gtttattttc tcttctgggc tccctacaac attgtccttc 3360
tcctgaacac cttccaggaa ttctttggcc tgaataattg cagtagctct aacaggttgg 3420
accaagctat gcaggtgaca gagactcttg ggatgacgca ctgctgcatc aaccccatca 3480
tctatgcctt tgtcggggag aagttcagaa actacctctt agtcttcttc caaaagcaca 3540
ttgccaaacg cttctgcaaa tgctgttcta ttttccagca agaggctccc gagcgagcaa 3600
gctcagttta cacccgatcc actggggagc aggaaatatc tgtgggcttg tgacacggac 3660
tcaagtgggc tggtgaccca gtcagagttg tgcacatggc ttagttttca tacacaccgc 3720
ggtctagagc atggctacgt agataagtag catggcgggt taatcattaa ctacaaggaa 3780
cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg 3840
cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg 3900
cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag 3960
cctgaatggc gaatggcgat tccgttgcaa tggctggcgg taatattgtt ctggatatta 4020
ccagcaaggc cgatagtttg agttcttcta ctcaggcaag tgatgttatt actaatcaaa 4080
gaagtattgc gacaacggtt aatttgcgtg atggacagac tcttttactc ggtggcctca 4140
ctgattataa aaacacttct caggattctg gcgtaccgtt cctgtctaaa atccctttaa 4200
tcggcctcct gtttagctcc cgctctgatt ctaacgagga aagcacgtta tacgtgctcg 4260
tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt 4320
acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc 4380
ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct 4440
ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat 4500
ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc 4560
acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc 4620
tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg 4680
atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat ttaaatattt 4740
gcttatacaa tcttcctgtt tttggggctt ttctgattat caaccggggt acatatgatt 4800
gacatgctag ttttacgatt accgttcatc gattctcttg tttgctccag actctcaggc 4860
aatgacctga tagcctttgt agagacctct caaaaatagc taccctctcc ggcatgaatt 4920
tatcagctag aacggttgaa tatcatattg atggtgattt gactgtctcc ggcctttctc 4980
acccgtttga atctttacct acacattact caggcattgc atttaaaata tatgagggtt 5040
ctaaaaattt ttatccttgc gttgaaataa aggcttctcc cgcaaaagta ttacagggtc 5100
ataatgtttt tggtacaacc gatttagctt tatgctctga ggctttattg cttaattttg 5160
ctaattcttt gccttgcctg tatgatttat tggatgttgg aatcgcctga tgcggtattt 5220
tctccttacg catctgtgcg gtatttcaca ccgcatatgg tgcactctca gtacaatctg 5280
ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg 5340
acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg 5400
catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat 5460
acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac 5520
ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat 5580
gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag 5640
tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc 5700
tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc 5760
acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc 5820
cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc 5880
ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt 5940
ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt 6000
atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat 6060
cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct 6120
tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat 6180
gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc 6240
ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg 6300
ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc 6360
tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta 6420
cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc 6480
ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga 6540
tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat 6600
gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat 6660
caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa 6720
accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa 6780
ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt 6840
aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt 6900
accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata 6960
gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt 7020
ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac 7080
gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga 7140
gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg 7200
ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa 7260
aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat 7320
gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc 7380
tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga 7440
agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatg       7494



<210> 20
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Protospacer for guide destination CCR5g

<400> 20
caauguguca acucuugaca                                             20

<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Protospacer for guide destination PRDM1g-1

<400> 21
aggatgcgga tatgactctg                                             20

<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Protospacer for guide destination PRDM1g-2

<400> 22
ggggagcgag tgatgtacgt                                             20

<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Protospacer for guide destination IRF4g

<400> 23
caagcaggac tacaaccgcg                                             20

<210> 24
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Protospacer for guide destination PAX5g

<400> 24
ugugaaugga cggccacucc                                             20

<210> 25
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Protospacer for guide destination BACH2g

<400> 25
guuccugcgc augcacaacc                                             20

<210> 26
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> tracrRNA binding sequence

<400> 26
guuuuagagc uaugcu                                                 16

<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for CCR5g for T7E1 assay

<400> 27
atgtgaagca aatcgcagcc                                             20

<210> 28
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for PRDM1g-1 for T7E1 assay

<400> 28
tagcatttaa aaaccttgct tcttttcaag                                  30

<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for PRDM1g-2 for T7E1 assay

<400> 29
cagtctaaag caaccgagca c                                           21

<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for CCR5g for T7E1 assay

<400> 30
tcccgagtag cagatgacca                                             20

<210> 31
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for PRDM1g-1 for T7E1 assay

<400> 31
tacagattct cagaggtttt cagaga                                      26

<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for PRDM1g-2 for T7E1 assay

<400> 32
cttggggtag tgagcgttgt a                                           21

<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer for CCR5g in the Illumina
      sequencing

<400> 33
ggcaacatgc tggtcatcct                                             20

<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer for PRDM1g-1 in the Illumina
      sequencing

<400> 34
ctctcagaag gagccacagg                                             20

<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer for PRDM1g-2 in the Illumina
      sequencing

<400> 35
cccctcacat cagaaaagga                                             20

<210> 36
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer for IRF4g in the Illumina
      sequencing

<400> 36
agatcgacag cggcaagta                                              19

<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer for PAX5g in the Illumina
      sequencing

<400> 37
cacagcggtg cttctcctat                                             20

<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> forward primer for BACH2g in the Illumina
      sequencing

<400> 38
tgagggattc gggacaatag                                             20

<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for CCR5g in the Illumina
      sequencing

<400> 39
ggtgaccgtc ctggctttta                                             20

<210> 40
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for PRDM1g-1 in the Illumina
      sequencing

<400> 40
ttggtggcat acttgaaaag c                                           21

<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for PRDM1g-2 in the Illumina
      sequencing

<400> 41
ctggagctct tgaggctttg                                             20

<210> 42
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for IRF4g in the Illumina
      sequencing

<400> 42
gaggcctcct ttcctcctc                                              19

<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for PAX5g in the Illumina
      sequencing

<400> 43
gcctcgagct actgccttta                                             20

<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for BACH2g in the Illumina
      sequencing

<400> 44
agttctcgca gtcctcgtgt                                             20

<210> 45
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for CCR5 (HDR) in the in-out ddPCR
      method

<400> 45
ggtatgatgc ttagaacagt gat                                         23

<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for ActB in the in-out ddPCR method

<400> 46
actctgcagg ttctatttgc                                             20

<210> 47
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for CCR5 (HDR) in the in-out ddPCR
      method

<400> 47
ccatattctg ctgttccaac t                                           21

<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for ActB in the in-out ddPCR method

<400> 48
aatgatctga ggagggaagg                                             20

<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Probe for CCR5 (HDR) in the in-out ddPCR method

<400> 49
cctgggcaac atagtgtgat c                                           21

<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Probe for ActB in the in-out ddPCR method

<400> 50
atcaaggtgg gtgtctttcc                                             20

<210> 51
<211> 4875
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1079_pscAAV-MND.GFP

<400> 51
aagcttcccg gggggatctg ggccactccc tctctgcgcg ctcgctcgct cactgaggcc 60
gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga 120
gcgcgcagag agggagtggc caactccatc actaggggtt cctggagggg tggagtcgtg 180
acctagggaa cagagaaaca ggagaatatg ggccaaacag gatatctgtg gtaagcagtt 240
cctgccccgg ctcagggcca agaacagttg gaacagcaga atatgggcca aacaggatat 300
ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc cagatgcggt 360
cccgccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc aaggacctga 420
aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg 480
cttctgctcc ccgagctcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg 540
agacgccatc cacgctgttt tgacttccat agaaggatcc tcgaggccac catggtgagc 600
aagggcgagg agctgttcac cggggtggtg cccatcctgg tcgagctgga cggcgacgta 660
aacggccaca agttcagcgt gtccggcgag ggcgagggcg atgccaccta cggcaagctg 720
accctgaagt tcatctgcac caccggcaag ctgcccgtgc cctggcccac cctcgtgacc 780
accctgacct acggcgtgca gtgcttcagc cgctaccccg accacatgaa gcagcacgac 840
ttcttcaagt ccgccatgcc cgaaggctac gtccaggagc gcaccatctt cttcaaggac 900
gacggcaact acaagacccg cgccgaggtg aagttcgagg gcgacaccct ggtgaaccgc 960
atcgagctga agggcatcga cttcaaggag gacggcaaca tcctggggca caagctggag 1020
tacaactaca acagccacaa cgtctatatc atggccgaca agcagaagaa cggcatcaag 1080
gtgaacttca agatccgcca caacatcgag gacggcagcg tgcagctcgc cgaccactac 1140
cagcagaaca cccccatcgg cgacggcccc gtgctgctgc ccgacaacca ctacctgagc 1200
acccagtccg ccctgagcaa agaccccaac gagaagcgcg atcacatggt cctgctggag 1260
ttcgtgaccg ccgccgggat cactctcggc atggacgagc tgtacaagta agcggccgca 1320
attcacccca ccagtgcagg ctgcctatca gaaagtggtg gctggtgtgg ctaatgccct 1380
ggcccacaag tatcactaag ctcgctttct tgctgtccaa tttctattaa aggttccttt 1440
gttccctaag tccaactact aaactggggg atattatgaa gggccttgag catctggatt 1500
ctgcctaata aaaaacattt attttcattg caatgatgta tttaaattat ttctgaatat 1560
tttactaaaa agggaatgtg ggaggtcagt gcatttaaaa cataaagaaa tgaagagcta 1620
gttcaaacct tgggaaaata cactatatct taaactccat gaaagaaggt gaggctgcaa 1680
acagctaatg cacattggca acagcccctg atgcctatgc cttattcatc cctcagaaaa 1740
ggattcaagt agaggcttga tttggaggtt aaagttttgc tatgctgtat tttacattac 1800
ttattgtttt agctgtcctc atgaatgtct tttcactacc catttgctta tcctgcatct 1860
ctcagccttg actccactca gttctcttgc ttagagatac cacctttccc ctgaagtgtt 1920
ccttccatgt tttacggcga gatggtttct cctcgcctgg ccactcagcc ttagttgtct 1980
ctgttgtctt atagaggtct acttgaagaa ggaaaaacag ggggcatggt ttgactgtcc 2040
tgtgagccct tcttccctgc ctcccccact cacagtgaca ctagtccact ccctctctgc 2100
gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc 2160
gggcggcctc agtgagcgag cgagcgcgca gagagggaca gatccgggcc cgcatgcgtc 2220
gacaattcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa 2280
cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc 2340
accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggcgcct gatgcggtat 2400
tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct cagtacaatc 2460
tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc 2520
tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc 2580
tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg 2640
atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc 2700
acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat 2760
atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag 2820
agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt 2880
cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt 2940
gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc 3000
cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta 3060
tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac 3120
ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa 3180
ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg 3240
atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc 3300
cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg 3360
atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta 3420
gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg 3480
cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg 3540
tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc 3600
tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt 3660
gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt 3720
gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc 3780
atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag 3840
atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa 3900
aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg 3960
aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt gtagccgtag 4020
ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg 4080
ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga 4140
tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc 4200
ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc 4260
acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga 4320
gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt 4380
cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg 4440
aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac 4500
atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga 4560
gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg 4620
gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatgcagc 4680
tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt 4740
tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg tatgttgtgt 4800
ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga ttacgccaag 4860
ctctcgagat ctaga                                                  4875

<210> 52
<211> 5056
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1347_pscAAV.Blimp.0.4kb.MND.GFP

<400> 52
aagcttcccg gggggatctg ggccactccc tctctgcgcg ctcgctcgct cactgaggcc 60
gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga 120
gcgcgcagag agggagtggc caactccatc actaggggtt cctggagggg tggagtcgtg 180
acctaggacg cgtgccagct gttactcagg ttttctcaag aaggaggagc aactttggca 240
gttttgcttc agttctctct agccctctgt gtaatcgccc ctttttcttt atttcagcac 300
aaacacagag cagtctaaag caaccgagca ctgagaaaaa tgaactctgc ccaaagaatg 360
tcccaaagag agagtacagc gtgaaagaaa tcctaaaatt ggactccaac ccctccaaag 420
gaaaggacct ctaccgttct aacatttcac ccctcacatc agaaaaggac ctcgatgact 480
ttagaagacg tgggagcccc gaaatgccct tctaccctcg ggtcgtttac cccatccggg 540
cccctctgcc agaagacttt ttgaaagctt ccctggccta cgggatcgag agagaacaga 600
gaaacaggag aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca 660
gggccaagaa cagttggaac agcagaatat gggccaaaca ggatatctgt ggtaagcagt 720
tcctgccccg gctcagggcc aagaacagat ggtccccaga tgcggtcccg ccctcagcag 780
tttctagaga accatcagat gtttccaggg tgccccaagg acctgaaatg accctgtgcc 840
ttatttgaac taaccaatca gttcgcttct cgcttctgtt cgcgcgcttc tgctccccga 900
gctctatata agcagagctc gtttagtgaa ccgtcagatc gcctggagac gccatccacg 960
ctgttttgac ttccatagaa ggatctcgag gccaccatgg tgagcaaggg cgaggagctg 1020
ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc 1080
agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc 1140
tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc 1200
gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc 1260
atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag 1320
acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc 1380
atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc 1440
cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc 1500
cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc 1560
atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg 1620
agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc 1680
gggatcactc tcggcatgga cgagctgtac aagtaaacta gtgtcgactg ctttatttgt 1740
gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac 1800
aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa 1860
aacgtacatc actcgctccc ccattccatc ctccaccact ccaagcccct ctgcaagaag 1920
cagccccgac caaagcctca agagctccag ccctcacagc agccctggga atacggtgtc 1980
ccctgtgggc cccggctctc aagagcaccg ggactcctac gcttacttga acgcgtccta 2040
cggcacggaa ggtttgggct cctaccctgg ctacgcaccc ctgccccacc tcccgccagc 2100
tttcatcccc tcgtacaacg ctcactaccc caagttcctc ttgcccccct acggcatgaa 2160
ttgtaatggc ctgagcgctg tgagcagcat gaatggcatc aacaactttg gcctcttccc 2220
gaggctgtgc cctgtctaca gcaatctcct cggtgggggc actagtccac tccctctctg 2280
cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc 2340
cgggcggcct cagtgagcga gcgagcgcgc agagagggac agatccgggc ccgcatgcgt 2400
cgacaattca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca 2460
acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg 2520
caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgcc tgatgcggta 2580
ttttctcctt acgcatctgt gcggtatttc acaccgcata tggtgcactc tcagtacaat 2640
ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc 2700
ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag 2760
ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt 2820
gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg 2880
cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa 2940
tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa 3000
gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct 3060
tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg 3120
tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg 3180
ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt 3240
atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga 3300
cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga 3360
attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac 3420
gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg 3480
ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac 3540
gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct 3600
agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct 3660
gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg 3720
gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat 3780
ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg 3840
tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat 3900
tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct 3960
catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa 4020
gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa 4080
aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc 4140
gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta 4200
gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct 4260
gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg 4320
atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag 4380
cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc 4440
cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg 4500
agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt 4560
tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg 4620
gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca 4680
catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg 4740
agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc 4800
ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag 4860
ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag 4920
ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg 4980
tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa 5040
gctctcgaga tctaga                                                 5056



<210> 53
<211> 6006
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1348_pAAV.Blimp.0.4kb.MND.GFP.pA

<400> 53
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtgcca 180
gctgttactc aggttttctc aagaaggagg agcaactttg gcagttttgc ttcagttctc 240
tctagccctc tgtgtaatcg cccctttttc tttatttcag cacaaacaca gagcagtcta 300
aagcaaccga gcactgagaa aaatgaactc tgcccaaaga atgtcccaaa gagagagtac 360
agcgtgaaag aaatcctaaa attggactcc aacccctcca aaggaaagga cctctaccgt 420
tctaacattt cacccctcac atcagaaaag gacctcgatg actttagaag acgtgggagc 480
cccgaaatgc ccttctaccc tcgggtcgtt taccccatcc gggcccctct gccagaagac 540
tttttgaaag cttccctggc ctacgggatc gagagagaac agagaaacag gagaatatgg 600
gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa gaacagttgg 660
aacagcagaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc ccggctcagg 720
gccaagaaca gatggtcccc agatgcggtc ccgccctcag cagtttctag agaaccatca 780
gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg aactaaccaa 840
tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctctat ataagcagag 900
ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacttccata 960
gaaggatctc gaggccacca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc 1020
catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg 1080
cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct 1140
gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg 1200
ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt 1260
ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa 1320
gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga 1380
cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat 1440
ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga 1500
cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt 1560
gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga 1620
gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat 1680
ggacgagctg tacaagtaaa ctagtgtcga ctgctttatt tgtgaaattt gtgatgctat 1740
tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca 1800
ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaaacgtac atcactcgct 1860
cccccattcc atcctccacc actccaagcc cctctgcaag aagcagcccc gaccaaagcc 1920
tcaagagctc cagccctcac agcagccctg ggaatacggt gtcccctgtg ggccccggct 1980
ctcaagagca ccgggactcc tacgcttact tgaacgcgtc ctacggcacg gaaggtttgg 2040
gctcctaccc tggctacgca cccctgcccc acctcccgcc agctttcatc ccctcgtaca 2100
acgctcacta ccccaagttc ctcttgcccc cctacggcat gaattgtaat ggcctgagcg 2160
ctgtgagcag catgaatggc atcaacaact ttggcctctt cccgaggctg tgccctgtct 2220
acagcaatct cctcggtggg ggcatctaga gtagataagt agcatggcgg gttaatcatt 2280
aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc 2340
actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg 2400
agcgagcgag cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca 2460
acagttgcgc agcctgaatg gcgaatggcg attccgttgc aatggctggc ggtaatattg 2520
ttctggatat taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta 2580
ttactaatca aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac 2640
tcggtggcct cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta 2700
aaatcccttt aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt 2760
tatacgtgct cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg 2820
ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct 2880
ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat 2940
cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt 3000
gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg 3060
acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac 3120
cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta 3180
aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca 3240
atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg 3300
gtacatatga ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc 3360
agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct 3420
ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct 3480
ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa 3540
tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag 3600
tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat 3660
tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct 3720
gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct 3780
cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc 3840
tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt 3900
ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa 3960
gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac 4020
gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat 4080
acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg 4140
aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc 4200
attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga 4260
tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga 4320
gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg 4380
cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc 4440
tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac 4500
agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact 4560
tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca 4620
tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg 4680
tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact 4740
acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg 4800
accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg 4860
tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat 4920
cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc 4980
tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat 5040
actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt 5100
tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc 5160
cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt 5220
gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac 5280
tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt 5340
gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct 5400
gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga 5460
ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac 5520
acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg 5580
agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt 5640
cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc 5700
tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg 5760
gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc 5820
ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc 5880
ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag 5940
cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca 6000
ttaatg                                                            6006



<210> 54
<211> 7206
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1361_pAAV.Blimp1.1.0kb.MND.GFP.pA

<400> 54
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac acgcgtggta 180
aaccatgaac atcagaaaga cttttattaa cctatgacag ggtccccacc ccagtatttt 240
tccactccat taaaatggaa gttttttttt tttttttctt ttttgagaca gagttttgct 300
cttgttgccc agtctggagt gcaatggcac aatctcggct caccacaacc tccacctccc 360
agattcaagc gattcttctg cctcagcctc ccaagtagct gggattacag gtgtgcgcca 420
ccacgcccag ctaattttgt atttttagta gagatggggt ttctccatgt tggtcaggct 480
ggtctcgaac ttccgacctc aggtgatccg cccacctcgg cctcccaaag tgctgggatt 540
acaggcaaga gccactgcat ccagcttagg ctatcttact ccagcctaaa cagcaatttt 600
ctatcataag gtctgtacta atgaaaacag aatcacccaa ggctgctgtt tgttctgtct 660
gtgctgccat tgtccgcatt ttgctgagga ggaaacggaa ctgcactttt gagtgagtgg 720
cccagagcct tctagaatga gagtgcgttg gaagccagat atgtggcgat tgtgtcgcca 780
gctgttactc aggttttctc aagaaggagg agcaactttg gcagttttgc ttcagttctc 840
tctagccctc tgtgtaatcg cccctttttc tttatttcag cacaaacaca gagcagtcta 900
aagcaaccga gcactgagaa aaatgaactc tgcccaaaga atgtcccaaa gagagagtac 960
agcgtgaaag aaatcctaaa attggactcc aacccctcca aaggaaagga cctctaccgt 1020
tctaacattt cacccctcac atcagaaaag gacctcgatg actttagaag acgtgggagc 1080
cccgaaatgc ccttctaccc tcgggtcgtt taccccatcc gggcccctct gccagaagac 1140
tttttgaaag cttccctggc ctacgggatc gagagagaac agagaaacag gagaatatgg 1200
gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa gaacagttgg 1260
aacagcagaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc ccggctcagg 1320
gccaagaaca gatggtcccc agatgcggtc ccgccctcag cagtttctag agaaccatca 1380
gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg aactaaccaa 1440
tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctctat ataagcagag 1500
ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacttccata 1560
gaaggatctc gaggccacca tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc 1620
catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg 1680
cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct 1740
gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg 1800
ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt 1860
ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa 1920
gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga 1980
cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat 2040
ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga 2100
cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt 2160
gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga 2220
gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat 2280
ggacgagctg tacaagtaaa ctagtgtcga ctgctttatt tgtgaaattt gtgatgctat 2340
tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca 2400
ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaaacgtac atcactcgct 2460
cccccattcc atcctccacc actccaagcc cctctgcaag aagcagcccc gaccaaagcc 2520
tcaagagctc cagccctcac agcagccctg ggaatacggt gtcccctgtg ggccccggct 2580
ctcaagagca ccgggactcc tacgcttact tgaacgcgtc ctacggcacg gaaggtttgg 2640
gctcctaccc tggctacgca cccctgcccc acctcccgcc agctttcatc ccctcgtaca 2700
acgctcacta ccccaagttc ctcttgcccc cctacggcat gaattgtaat ggcctgagcg 2760
ctgtgagcag catgaatggc atcaacaact ttggcctctt cccgaggctg tgccctgtct 2820
acagcaatct cctcggtggg ggcagcctgc cccaccccat gctcaacccc acttctctcc 2880
cgagctcgct gccctcagat ggagcccgga ggttgctcca gccggagcat cccagggagg 2940
tgcttgtccc ggcgccccac agtgccttct cctttaccgg ggccgccgcc agcatgaagg 3000
acaaggcctg tagccccaca agcgggtctc ccacggcggg aacagccgcc acggcagaac 3060
atgtggtgca gcccaaagct acctcagcag cgatggcagc ccccagcagc gacgaagcca 3120
tgaatctcat taaaaacaaa agaaacatga ccggctacaa gacccttccc tacccgctga 3180
agaagcagaa cggcaagatc aagtacgaat gcaacgtttg cgccaagact ttcggccagc 3240
tctccaatct gaaggtaggc cttgagagag agcagtccaa ggggctgtga gtgcatgctt 3300
gtgtttgtat ttagcttgct ttccatgggg tatcgattgc atttgcagta gtatgagccc 3360
ccggttgggg atagtgggta tggattccgc ctggcttttg ccacttctag ctctttgact 3420
ttggacaagt gacttccctt ctcctctaga gtagataagt agcatggcgg gttaatcatt 3480
aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc 3540
actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg 3600
agcgagcgag cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca 3660
acagttgcgc agcctgaatg gcgaatggcg attccgttgc aatggctggc ggtaatattg 3720
ttctggatat taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta 3780
ttactaatca aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac 3840
tcggtggcct cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta 3900
aaatcccttt aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt 3960
tatacgtgct cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg 4020
ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct 4080
ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat 4140
cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt 4200
gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg 4260
acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac 4320
cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta 4380
aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca 4440
atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg 4500
gtacatatga ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc 4560
agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct 4620
ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct 4680
ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa 4740
tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag 4800
tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat 4860
tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct 4920
gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct 4980
cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc 5040
tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt 5100
ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa 5160
gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac 5220
gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat 5280
acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg 5340
aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc 5400
attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga 5460
tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga 5520
gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg 5580
cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc 5640
tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac 5700
agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact 5760
tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca 5820
tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg 5880
tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact 5940
acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg 6000
accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg 6060
tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat 6120
cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc 6180
tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat 6240
actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt 6300
tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc 6360
cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt 6420
gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac 6480
tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt 6540
gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct 6600
gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga 6660
ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac 6720
acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg 6780
agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt 6840
cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc 6900
tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg 6960
gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc 7020
ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc 7080
ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag 7140
cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca 7200
ttaatg                                                            7206



<210> 55
<211> 6707
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1366_CCR5.MND.BAFF_CRISPR.HR

<400> 55
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tttggtgtgg tggcgcctgt agtccccagc cacttggagg ggtgaggtga gaggattgct 300
tgagcccggg atggtccagg ctgcagtgag ccatgatcgt gccactgcac tccagcctgg 360
gcgacagagt gagaccctgt ctcacaacaa caacaacaac aacaaaaagg ctgagctgca 420
ccatgcttga cccagtttct taaaattgtt gtcaaagctt cattcactcc atggtgctat 480
agagcacaag attttatttg gtgagatggt gctttcatga attcccccaa cagagccaag 540
ctctccatct agtggacagg gaagctagca gcaaaccttc ccttcactac aaaacttcat 600
tgcttggcca aaaagagagt taattcaatg tagacatcta tgtaggcaat taaaaaccta 660
ttgatgtata aaacagtttg cattcatgga gggcaactaa atacattcta ggactttata 720
aaagatcact ttttatttat gcacagggtg gaacaagatg gattatcaag tgtcaagtcc 780
aatctatgac atcaattatt atacatcgga gccctgccaa aaaatcaatg tgaagcaaat 840
cgcagcccgc ctcctgcctc cgctctactc actggtgttc atctttggtt ttgtgggcaa 900
catgctggtc atcctcatcc tgataaactg caaaaggctg aagagcatga ctgacatcta 960
cctgctcaac ctggccatct ctgacctgtt tttccttctt actgtcccct tctgggctca 1020
ctatgctgcc gcccagtggg actttggaaa tacaatgtgt caacgaacag agaaacagga 1080
gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga 1140
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc 1200
ggctcagggc caagaacaga tggtccccag atgcggtccc gccctcagca gtttctagag 1260
aaccatcaga tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa 1320
ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctctatat 1380
aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 1440
cttccataga aggatctcga ggccaccatg taccggatgc agctgctgag ctgcatcgca 1500
ctgagcctgg cactggtgac caacagcgca gtgcagggac cagaggagac cgtgacccag 1560
gactgcctgc agctgatcgc agacagcgag acccccacca tccagaaggg cagctacacc 1620
ttcgtgccct ggctgctgag cttcaagcgg ggcagcgccc tggaggagaa ggagaacaag 1680
attctggtga aggagaccgg ctacttcttc atctacggcc aggtgctgta caccgataag 1740
acctacgcca tgggccacct gatccagcgg aagaaggtgc acgtgttcgg cgacgagctg 1800
agcctggtga ccctgttccg gtgcatccag aacatgcccg agaccctgcc caacaacagc 1860
tgctacagcg caggaatcgc aaagctggag gagggcgacg agctgcagct ggcaatcccc 1920
cgggagaacg cacagatcag cctggacggc gacgtgacct tcttcggcgc cctgaagctc 1980
ctgtgagtcg actgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt 2040
ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag 2100
ggggaggtgt gggaggtttt ttaaactcta ttttataggc ttcttctctg gaatcttctt 2160
catcatcctc ctgacaatcg ataggtacct ggctgtcgtc catgctgtgt ttgctttaaa 2220
agccaggacg gtcacctttg gggtggtgac aagtgtgatc acttgggtgg tggctgtgtt 2280
tgcgtctctc ccaggaatca tctttaccag atctcaaaaa gaaggtcttc attacacctg 2340
cagctctcat tttccataca gtcagtatca attctggaag aatttccaga cattaaagat 2400
agtcatcttg gggctggtcc tgccgctgct tgtcatggtc atctgctact cgggaatcct 2460
aaaaactctg cttcggtgtc gaaatgagaa gaagaggcac agggctgtga ggcttatctt 2520
caccatcatg attgtttatt ttctcttctg ggctccctac aacattgtcc ttctcctgaa 2580
caccttccag gaattctttg gcctgaataa ttgcagtagc tctaacaggt tggaccaagc 2640
tatgcaggtg acagagactc ttgggatgac gcactgctgc atcaacccca tcatctatgc 2700
ctttgtcggg gagaagttca gaaactacct cttagtcttc ttccaaaagc acattgccaa 2760
acgcttctgc aaatgctgtt ctattttcca gcaagaggct cccgagcgag caagctcagt 2820
ttacacccga tccactgggg agcaggaaat atctgtgggc ttgtgacacg gactcaagtg 2880
ggctggtgac ccagtcagag ttgtgcacat ggcttagttt tcatacacac cgcggtctag 2940
agcatggcta cgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag 3000
tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa 3060
aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgccagc 3120
tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat 3180
ggcgaatggc gattccgttg caatggctgg cggtaatatt gttctggata ttaccagcaa 3240
ggccgatagt ttgagttctt ctactcaggc aagtgatgtt attactaatc aaagaagtat 3300
tgcgacaacg gttaatttgc gtgatggaca gactctttta ctcggtggcc tcactgatta 3360
taaaaacact tctcaggatt ctggcgtacc gttcctgtct aaaatccctt taatcggcct 3420
cctgtttagc tcccgctctg attctaacga ggaaagcacg ttatacgtgc tcgtcaaagc 3480
aaccatagta cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca 3540
gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct 3600
ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt 3660
tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac 3720
gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct 3780
ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt 3840
ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac 3900
aaaaatttaa cgcgaatttt aacaaaatat taacgtttac aatttaaata tttgcttata 3960
caatcttcct gtttttgggg cttttctgat tatcaaccgg ggtacatatg attgacatgc 4020
tagttttacg attaccgttc atcgattctc ttgtttgctc cagactctca ggcaatgacc 4080
tgatagcctt tgtagagacc tctcaaaaat agctaccctc tccggcatga atttatcagc 4140
tagaacggtt gaatatcata ttgatggtga tttgactgtc tccggccttt ctcacccgtt 4200
tgaatcttta cctacacatt actcaggcat tgcatttaaa atatatgagg gttctaaaaa 4260
tttttatcct tgcgttgaaa taaaggcttc tcccgcaaaa gtattacagg gtcataatgt 4320
ttttggtaca accgatttag ctttatgctc tgaggcttta ttgcttaatt ttgctaattc 4380
tttgccttgc ctgtatgatt tattggatgt tggaatcgcc tgatgcggta ttttctcctt 4440
acgcatctgt gcggtatttc acaccgcata tggtgcactc tcagtacaat ctgctctgat 4500
gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct 4560
tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt 4620
cagaggtttt caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta 4680
tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg 4740
ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg 4800
ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt 4860
attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt 4920
gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg 4980
ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa 5040
cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt 5100
gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag 5160
tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt 5220
gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga 5280
ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt 5340
tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta 5400
gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg 5460
caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc 5520
cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt 5580
atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg 5640
gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg 5700
attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa 5760
cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa 5820
atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga 5880
tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg 5940
ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact 6000
ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac 6060
cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg 6120
gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg 6180
gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga 6240
acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc 6300
gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg 6360
agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc 6420
tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc 6480
agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt 6540
cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc 6600
gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc 6660
ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatg               6707



<210> 56
<211> 7494
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1367_CCR5.MND.BAFF.2A.GFP

<400> 56
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tttggtgtgg tggcgcctgt agtccccagc cacttggagg ggtgaggtga gaggattgct 300
tgagcccggg atggtccagg ctgcagtgag ccatgatcgt gccactgcac tccagcctgg 360
gcgacagagt gagaccctgt ctcacaacaa caacaacaac aacaaaaagg ctgagctgca 420
ccatgcttga cccagtttct taaaattgtt gtcaaagctt cattcactcc atggtgctat 480
agagcacaag attttatttg gtgagatggt gctttcatga attcccccaa cagagccaag 540
ctctccatct agtggacagg gaagctagca gcaaaccttc ccttcactac aaaacttcat 600
tgcttggcca aaaagagagt taattcaatg tagacatcta tgtaggcaat taaaaaccta 660
ttgatgtata aaacagtttg cattcatgga gggcaactaa atacattcta ggactttata 720
aaagatcact ttttatttat gcacagggtg gaacaagatg gattatcaag tgtcaagtcc 780
aatctatgac atcaattatt atacatcgga gccctgccaa aaaatcaatg tgaagcaaat 840
cgcagcccgc ctcctgcctc cgctctactc actggtgttc atctttggtt ttgtgggcaa 900
catgctggtc atcctcatcc tgataaactg caaaaggctg aagagcatga ctgacatcta 960
cctgctcaac ctggccatct ctgacctgtt tttccttctt actgtcccct tctgggctca 1020
ctatgctgcc gcccagtggg actttggaaa tacaatgtgt caacgaacag agaaacagga 1080
gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga 1140
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc 1200
ggctcagggc caagaacaga tggtccccag atgcggtccc gccctcagca gtttctagag 1260
aaccatcaga tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa 1320
ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctctatat 1380
aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 1440
cttccataga aggatctcga ggccaccatg taccggatgc agctgctgag ctgcatcgca 1500
ctgagcctgg cactggtgac caacagcgca gtgcagggac cagaggagac cgtgacccag 1560
gactgcctgc agctgatcgc agacagcgag acccccacca tccagaaggg cagctacacc 1620
ttcgtgccct ggctgctgag cttcaagcgg ggcagcgccc tggaggagaa ggagaacaag 1680
attctggtga aggagaccgg ctacttcttc atctacggcc aggtgctgta caccgataag 1740
acctacgcca tgggccacct gatccagcgg aagaaggtgc acgtgttcgg cgacgagctg 1800
agcctggtga ccctgttccg gtgcatccag aacatgcccg agaccctgcc caacaacagc 1860
tgctacagcg caggaatcgc aaagctggag gagggcgacg agctgcagct ggcaatcccc 1920
cgggagaacg cacagatcag cctggacggc gacgtgacct tcttcggcgc cctgaagctc 1980
ctgggatccg gtgagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccg 2040
ggccccatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag 2100
ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc 2160
acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg 2220
cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac 2280
atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc 2340
atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac 2400
accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg 2460
gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag 2520
aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag 2580
ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac 2640
aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac 2700
atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac 2760
aagtgaatct agagtcgact gctttatttg tgaaatttgt gatgctattg ctttatttgt 2820
aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca 2880
ggttcagggg gaggtgtggg aggtttttta aactctattt tataggcttc ttctctggaa 2940
tcttcttcat catcctcctg acaatcgata ggtacctggc tgtcgtccat gctgtgtttg 3000
ctttaaaagc caggacggtc acctttgggg tggtgacaag tgtgatcact tgggtggtgg 3060
ctgtgtttgc gtctctccca ggaatcatct ttaccagatc tcaaaaagaa ggtcttcatt 3120
acacctgcag ctctcatttt ccatacagtc agtatcaatt ctggaagaat ttccagacat 3180
taaagatagt catcttgggg ctggtcctgc cgctgcttgt catggtcatc tgctactcgg 3240
gaatcctaaa aactctgctt cggtgtcgaa atgagaagaa gaggcacagg gctgtgaggc 3300
ttatcttcac catcatgatt gtttattttc tcttctgggc tccctacaac attgtccttc 3360
tcctgaacac cttccaggaa ttctttggcc tgaataattg cagtagctct aacaggttgg 3420
accaagctat gcaggtgaca gagactcttg ggatgacgca ctgctgcatc aaccccatca 3480
tctatgcctt tgtcggggag aagttcagaa actacctctt agtcttcttc caaaagcaca 3540
ttgccaaacg cttctgcaaa tgctgttcta ttttccagca agaggctccc gagcgagcaa 3600
gctcagttta cacccgatcc actggggagc aggaaatatc tgtgggcttg tgacacggac 3660
tcaagtgggc tggtgaccca gtcagagttg tgcacatggc ttagttttca tacacaccgc 3720
ggtctagagc atggctacgt agataagtag catggcgggt taatcattaa ctacaaggaa 3780
cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg 3840
cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg 3900
cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag 3960
cctgaatggc gaatggcgat tccgttgcaa tggctggcgg taatattgtt ctggatatta 4020
ccagcaaggc cgatagtttg agttcttcta ctcaggcaag tgatgttatt actaatcaaa 4080
gaagtattgc gacaacggtt aatttgcgtg atggacagac tcttttactc ggtggcctca 4140
ctgattataa aaacacttct caggattctg gcgtaccgtt cctgtctaaa atccctttaa 4200
tcggcctcct gtttagctcc cgctctgatt ctaacgagga aagcacgtta tacgtgctcg 4260
tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt 4320
acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc 4380
ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct 4440
ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat 4500
ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc 4560
acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc 4620
tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg 4680
atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat ttaaatattt 4740
gcttatacaa tcttcctgtt tttggggctt ttctgattat caaccggggt acatatgatt 4800
gacatgctag ttttacgatt accgttcatc gattctcttg tttgctccag actctcaggc 4860
aatgacctga tagcctttgt agagacctct caaaaatagc taccctctcc ggcatgaatt 4920
tatcagctag aacggttgaa tatcatattg atggtgattt gactgtctcc ggcctttctc 4980
acccgtttga atctttacct acacattact caggcattgc atttaaaata tatgagggtt 5040
ctaaaaattt ttatccttgc gttgaaataa aggcttctcc cgcaaaagta ttacagggtc 5100
ataatgtttt tggtacaacc gatttagctt tatgctctga ggctttattg cttaattttg 5160
ctaattcttt gccttgcctg tatgatttat tggatgttgg aatcgcctga tgcggtattt 5220
tctccttacg catctgtgcg gtatttcaca ccgcatatgg tgcactctca gtacaatctg 5280
ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg 5340
acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg 5400
catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat 5460
acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac 5520
ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat 5580
gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag 5640
tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc 5700
tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc 5760
acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc 5820
cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc 5880
ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt 5940
ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt 6000
atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat 6060
cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct 6120
tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat 6180
gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc 6240
ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg 6300
ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc 6360
tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta 6420
cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc 6480
ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga 6540
tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat 6600
gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat 6660
caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa 6720
accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa 6780
ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt 6840
aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt 6900
accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata 6960
gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt 7020
ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac 7080
gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga 7140
gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg 7200
ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa 7260
aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat 7320
gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc 7380
tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga 7440
agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatg       7494



<210> 57
<211> 8330
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1378_CCR5.MND.mCherry.2A.coFIXpadua.WPRE.pa

<400> 57
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tttggtgtgg tggcgcctgt agtccccagc cacttggagg ggtgaggtga gaggattgct 300
tgagcccggg atggtccagg ctgcagtgag ccatgatcgt gccactgcac tccagcctgg 360
gcgacagagt gagaccctgt ctcacaacaa caacaacaac aacaaaaagg ctgagctgca 420
ccatgcttga cccagtttct taaaattgtt gtcaaagctt cattcactcc atggtgctat 480
agagcacaag attttatttg gtgagatggt gctttcatga attcccccaa cagagccaag 540
ctctccatct agtggacagg gaagctagca gcaaaccttc ccttcactac aaaacttcat 600
tgcttggcca aaaagagagt taattcaatg tagacatcta tgtaggcaat taaaaaccta 660
ttgatgtata aaacagtttg cattcatgga gggcaactaa atacattcta ggactttata 720
aaagatcact ttttatttat gcacagggtg gaacaagatg gattatcaag tgtcaagtcc 780
aatctatgac atcaattatt atacatcgga gccctgccaa aaaatcaatg tgaagcaaat 840
cgcagcccgc ctcctgcctc cgctctactc actggtgttc atctttggtt ttgtgggcaa 900
catgctggtc atcctcatcc tgataaactg caaaaggctg aagagcatga ctgacatcta 960
cctgctcaac ctggccatct ctgacctgtt tttccttctt actgtcccct tctgggctca 1020
ctatgctgcc gcccagtggg actttggaaa tacaatgtgt caacgaacag agaaacagga 1080
gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga 1140
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc 1200
ggctcagggc caagaacaga tggtccccag atgcggtccc gccctcagca gtttctagag 1260
aaccatcaga tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa 1320
ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctctatat 1380
aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 1440
cttccataga aggatctcga ggccaccatg gtgagcaagg gcgaggagga taacatggcc 1500
atcatcaagg agttcatgcg cttcaaggtg cacatggagg gctccgtgaa cggccacgag 1560
ttcgagatcg agggcgaggg cgagggccgc ccctacgagg gcacccagac cgccaagctg 1620
aaggtgacca agggtggccc cctgcccttc gcctgggaca tcctgtcccc tcagttcatg 1680
tacggctcca aggcctacgt gaagcacccc gccgacatcc ccgactactt gaagctgtcc 1740
ttccccgagg gcttcaagtg ggagcgcgtg atgaacttcg aggacggcgg cgtggtgacc 1800
gtgacccagg actcctctct gcaggacggc gagttcatct acaaggtgaa gctgcgcggc 1860
accaacttcc cctccgacgg ccccgtaatg cagaagaaga ccatgggctg ggaggcctcc 1920
tccgagcgga tgtaccccga ggacggcgcc ctgaagggcg agatcaagca gaggctgaag 1980
ctgaaggacg gcggccacta cgacgctgag gtcaagacca cctacaaggc caagaagccc 2040
gtgcagctgc ccggcgccta caacgtcaac atcaagttgg acatcacctc ccacaacgag 2100
gactacacca tcgtggaaca gtacgaacgc gccgagggcc gccactccac cggcggcatg 2160
gacgagctgt acaagggatc cggtgagggc agaggaagtc ttctaacatg cggtgacgtg 2220
gaggagaatc cgggccccat gatcatggcc gagagccctg gcctgatcac catctgcctg 2280
ctgggctacc tgctgagcgc cgagtgcacc gtgttcctgg accacgagaa cgccaacaag 2340
atcctgaacc ggcccaagag atacaacagc ggcaagctgg aggagttcgt gcagggcaac 2400
ctggagaggg agtgcatgga ggagaagtgc agcttcgagg aggccaggga agtgttcgag 2460
aacaccgagc ggaccaccga gttctggaag cagtacgtgg acggcgacca gtgcgagagc 2520
aacccttgcc tgaacggcgg cagctgcaag gacgacatca acagctacga gtgctggtgc 2580
cctttcggct tcgagggcaa gaactgcgag ctggacgtga cctgcaacat caagaacggc 2640
cgctgcgagc agttctgcaa gaacagcgcc gacaacaaag tggtgtgtag ctgcaccgag 2700
ggctacagac tggccgagaa ccagaagagc tgcgagcccg ccgtgccctt cccctgcggc 2760
agagtgagcg tgtcccagac cagcaagctg accagagccg agaccgtgtt ccccgacgtg 2820
gactacgtga atagcaccga ggccgagacc atcctggaca acatcaccca gagcacccag 2880
tccttcaacg acttcaccag agttgtgggc ggcgaggacg ccaagcccgg ccagttcccc 2940
tggcaggtgg tgctgaacgg caaagtggat gccttctgcg gcggcagcat cgtgaacgag 3000
aagtggatcg tgacagccgc ccactgcgtg gagaccggcg tgaagatcac cgtggtggcc 3060
ggcgaacaca atatcgagga gaccgagcac accgagcaga agcggaacgt catccggatt 3120
atcccccacc acaactacaa cgccgccatc aacaagtaca accacgacat cgccctgctg 3180
gagctggacg agcctctggt gctgaatagc tacgtgaccc ccatctgcat cgccgacaag 3240
gagtacacca acatcttcct gaagttcggc agcggctacg tgtccggctg gggcagagtg 3300
ttccacaagg gcagaagcgc cctggtgctg cagtacctga gagtgcccct ggtggacaga 3360
gccacctgcc tgttgagcac caagttcacc atctacaaca acatgttctg cgccggcttc 3420
cacgagggcg gcagagacag ctgccagggc gacagcggcg gaccccacgt gaccgaagtg 3480
gagggcacca gcttcctgac cggcatcatc agctggggcg aggagtgcgc catgaagggc 3540
aagtacggca tctacaccaa agtgagccgg tacgtgaact ggatcaagga gaaaaccaag 3600
ctgacctgag tcgactgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc 3660
attataagct gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt 3720
cagggggagg tgtgggaggt tttttaaact ctattttata ggcttcttct ctggaatctt 3780
cttcatcatc ctcctgacaa tcgataggta cctggctgtc gtccatgctg tgtttgcttt 3840
aaaagccagg acggtcacct ttggggtggt gacaagtgtg atcacttggg tggtggctgt 3900
gtttgcgtct ctcccaggaa tcatctttac cagatctcaa aaagaaggtc ttcattacac 3960
ctgcagctct cattttccat acagtcagta tcaattctgg aagaatttcc agacattaaa 4020
gatagtcatc ttggggctgg tcctgccgct gcttgtcatg gtcatctgct actcgggaat 4080
cctaaaaact ctgcttcggt gtcgaaatga gaagaagagg cacagggctg tgaggcttat 4140
cttcaccatc atgattgttt attttctctt ctgggctccc tacaacattg tccttctcct 4200
gaacaccttc caggaattct ttggcctgaa taattgcagt agctctaaca ggttggacca 4260
agctatgcag gtgacagaga ctcttgggat gacgcactgc tgcatcaacc ccatcatcta 4320
tgcctttgtc ggggagaagt tcagaaacta cctcttagtc ttcttccaaa agcacattgc 4380
caaacgcttc tgcaaatgct gttctatttt ccagcaagag gctcccgagc gagcaagctc 4440
agtttacacc cgatccactg gggagcagga aatatctgtg ggcttgtgac acggactcaa 4500
gtgggctggt gacccagtca gagttgtgca catggcttag ttttcataca caccgcggtc 4560
tagagcatgg ctacgtagat aagtagcatg gcgggttaat cattaactac aaggaacccc 4620
tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac 4680
caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgcc 4740
agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg 4800
aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg atattaccag 4860
caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta atcaaagaag 4920
tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg gcctcactga 4980
ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc ctttaatcgg 5040
cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg tgctcgtcaa 5100
agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc 5160
gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt 5220
cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag 5280
ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt 5340
cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt 5400
tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt 5460
cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt 5520
aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttaa atatttgctt 5580
atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat atgattgaca 5640
tgctagtttt acgattaccg ttcatcgatt ctcttgtttg ctccagactc tcaggcaatg 5700
acctgatagc ctttgtagag acctctcaaa aatagctacc ctctccggca tgaatttatc 5760
agctagaacg gttgaatatc atattgatgg tgatttgact gtctccggcc tttctcaccc 5820
gtttgaatct ttacctacac attactcagg cattgcattt aaaatatatg agggttctaa 5880
aaatttttat ccttgcgttg aaataaaggc ttctcccgca aaagtattac agggtcataa 5940
tgtttttggt acaaccgatt tagctttatg ctctgaggct ttattgctta attttgctaa 6000
ttctttgcct tgcctgtatg atttattgga tgttggaatc gcctgatgcg gtattttctc 6060
cttacgcatc tgtgcggtat ttcacaccgc atatggtgca ctctcagtac aatctgctct 6120
gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc gccctgacgg 6180
gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg gagctgcatg 6240
tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc 6300
ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt 6360
cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat 6420
ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg 6480
agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt 6540
tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga 6600
gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa 6660
gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt 6720
attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt 6780
gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc 6840
agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga 6900
ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat 6960
cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct 7020
gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc 7080
cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg 7140
gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc 7200
ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg 7260
acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca 7320
ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta 7380
aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc 7440
aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa 7500
ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca 7560
ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta 7620
actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc 7680
caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca 7740
gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta 7800
ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag 7860
cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt 7920
cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc 7980
acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac 8040
ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac 8100
gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc 8160
tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat 8220
accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag 8280
cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg            8330



<210> 58
<211> 7806
<212> DNA
<213> Artificial Sequence

<220> 
<223> 1376_CCR5.MND.FiX.coFIXpadua.WPRE.pA

<400> 58
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tttggtgtgg tggcgcctgt agtccccagc cacttggagg ggtgaggtga gaggattgct 300
tgagcccggg atggtccagg ctgcagtgag ccatgatcgt gccactgcac tccagcctgg 360
gcgacagagt gagaccctgt ctcacaacaa caacaacaac aacaaaaagg ctgagctgca 420
ccatgcttga cccagtttct taaaattgtt gtcaaagctt cattcactcc atggtgctat 480
agagcacaag attttatttg gtgagatggt gctttcatga attcccccaa cagagccaag 540
ctctccatct agtggacagg gaagctagca gcaaaccttc ccttcactac aaaacttcat 600
tgcttggcca aaaagagagt taattcaatg tagacatcta tgtaggcaat taaaaaccta 660
ttgatgtata aaacagtttg cattcatgga gggcaactaa atacattcta ggactttata 720
aaagatcact ttttatttat gcacagggtg gaacaagatg gattatcaag tgtcaagtcc 780
aatctatgac atcaattatt atacatcgga gccctgccaa aaaatcaatg tgaagcaaat 840
cgcagcccgc ctcctgcctc cgctctactc actggtgttc atctttggtt ttgtgggcaa 900
catgctggtc atcctcatcc tgataaactg caaaaggctg aagagcatga ctgacatcta 960
cctgctcaac ctggccatct ctgacctgtt tttccttctt actgtcccct tctgggctca 1020
ctatgctgcc gcccagtggg actttggaaa tacaatgtgt caacgaacag agaaacagga 1080
gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga 1140
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc 1200
ggctcagggc caagaacaga tggtccccag atgcggtccc gccctcagca gtttctagag 1260
aaccatcaga tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa 1320
ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctctatat 1380
aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 1440
cttccataga aggatctcga gatgatcatg gccgagagcc ctggcctgat caccatctgc 1500
ctgctgggct acctgctgag cgccgagtgc accgtgttcc tggaccacga gaacgccaac 1560
aagatcctga accggcccaa gagatacaac agcggcaagc tggaggagtt cgtgcagggc 1620
aacctggaga gggagtgcat ggaggagaag tgcagcttcg aggaggccag ggaagtgttc 1680
gagaacaccg agcggaccac cgagttctgg aagcagtacg tggacggcga ccagtgcgag 1740
agcaaccctt gcctgaacgg cggcagctgc aaggacgaca tcaacagcta cgagtgctgg 1800
tgccctttcg gcttcgaggg caagaactgc gagctggacg tgacctgcaa catcaagaac 1860
ggccgctgcg agcagttctg caagaacagc gccgacaaca aagtggtgtg tagctgcacc 1920
gagggctaca gactggccga gaaccagaag agctgcgagc ccgccgtgcc cttcccctgc 1980
ggcagagtga gcgtgtccca gaccagcaag ctgaccagag ccgagaccgt gttccccgac 2040
gtggactacg tgaatagcac cgaggccgag accatcctgg acaacatcac ccagagcacc 2100
cagtccttca acgacttcac cagagttgtg ggcggcgagg acgccaagcc cggccagttc 2160
ccctggcagg tggtgctgaa cggcaaagtg gatgccttct gcggcggcag catcgtgaac 2220
gagaagtgga tcgtgacagc cgcccactgc gtggagaccg gcgtgaagat caccgtggtg 2280
gccggcgaac acaatatcga ggagaccgag cacaccgagc agaagcggaa cgtcatccgg 2340
attatccccc accacaacta caacgccgcc atcaacaagt acaaccacga catcgccctg 2400
ctggagctgg acgagcctct ggtgctgaat agctacgtga cccccatctg catcgccgac 2460
aaggagtaca ccaacatctt cctgaagttc ggcagcggct acgtgtccgg ctggggcaga 2520
gtgttccaca agggcagaag cgccctggtg ctgcagtacc tgagagtgcc cctggtggac 2580
agagccacct gcctgttgag caccaagttc accatctaca acaacatgtt ctgcgccggc 2640
ttccacgagg gcggcagaga cagctgccag ggcgacagcg gcggacccca cgtgaccgaa 2700
gtggagggca ccagcttcct gaccggcatc atcagctggg gcgaggagtg cgccatgaag 2760
ggcaagtacg gcatctacac caaagtgagc cggtacgtga actggatcaa ggagaaaacc 2820
aagctgacct gagtcgacga taatcaacct ctggattaca aaatttgtga aagattgact 2880
ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg 2940
tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggtta 3000
gttcttgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg 3060
ctgttgggca ctgacaattc cgtgggtcga ctgctttatt tgtgaaattt gtgatgctat 3120
tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca 3180
ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaactctat tttataggct 3240
tcttctctgg aatcttcttc atcatcctcc tgacaatcga taggtacctg gctgtcgtcc 3300
atgctgtgtt tgctttaaaa gccaggacgg tcacctttgg ggtggtgaca agtgtgatca 3360
cttgggtggt ggctgtgttt gcgtctctcc caggaatcat ctttaccaga tctcaaaaag 3420
aaggtcttca ttacacctgc agctctcatt ttccatacag tcagtatcaa ttctggaaga 3480
atttccagac attaaagata gtcatcttgg ggctggtcct gccgctgctt gtcatggtca 3540
tctgctactc gggaatccta aaaactctgc ttcggtgtcg aaatgagaag aagaggcaca 3600
gggctgtgag gcttatcttc accatcatga ttgtttattt tctcttctgg gctccctaca 3660
acattgtcct tctcctgaac accttccagg aattctttgg cctgaataat tgcagtagct 3720
ctaacaggtt ggaccaagct atgcaggtga cagagactct tgggatgacg cactgctgca 3780
tcaaccccat catctatgcc tttgtcgggg agaagttcag aaactacctc ttagtcttct 3840
tccaaaagca cattgccaaa cgcttctgca aatgctgttc tattttccag caagaggctc 3900
ccgagcgagc aagctcagtt tacacccgat ccactgggga gcaggaaata tctgtgggct 3960
tgtgacacgg actcaagtgg gctggtgacc cagtcagagt tgtgcacatg gcttagtttt 4020
catacacacc gcggtctaga gcatggctac gtagataagt agcatggcgg gttaatcatt 4080
aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc 4140
actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg 4200
agcgagcgag cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca 4260
acagttgcgc agcctgaatg gcgaatggcg attccgttgc aatggctggc ggtaatattg 4320
ttctggatat taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta 4380
ttactaatca aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac 4440
tcggtggcct cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta 4500
aaatcccttt aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt 4560
tatacgtgct cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg 4620
ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct 4680
ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat 4740
cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt 4800
gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg 4860
acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac 4920
cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta 4980
aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca 5040
atttaaatat ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg 5100
gtacatatga ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc 5160
agactctcag gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct 5220
ccggcatgaa tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct 5280
ccggcctttc tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa 5340
tatatgaggg ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag 5400
tattacaggg tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat 5460
tgcttaattt tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct 5520
gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct 5580
cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc 5640
tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt 5700
ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa 5760
gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac 5820
gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat 5880
acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg 5940
aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc 6000
attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga 6060
tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga 6120
gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg 6180
cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc 6240
tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac 6300
agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact 6360
tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca 6420
tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg 6480
tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact 6540
acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg 6600
accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg 6660
tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat 6720
cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc 6780
tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat 6840
actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt 6900
tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc 6960
cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt 7020
gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac 7080
tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt 7140
gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct 7200
gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga 7260
ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac 7320
acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg 7380
agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt 7440
cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc 7500
tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg 7560
gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc 7620
ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc 7680
ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag 7740
cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca 7800
ttaatg                                                            7806



<210> 59
<211> 6968
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAAV_CCR5.MND.II2ss.ADP.mAPRIL

<400> 59
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tttggtgtgg tggcgcctgt agtccccagc cacttggagg ggtgaggtga gaggattgct 300
tgagcccggg atggtccagg ctgcagtgag ccatgatcgt gccactgcac tccagcctgg 360
gcgacagagt gagaccctgt ctcacaacaa caacaacaac aacaaaaagg ctgagctgca 420
ccatgcttga cccagtttct taaaattgtt gtcaaagctt cattcactcc atggtgctat 480
agagcacaag attttatttg gtgagatggt gctttcatga attcccccaa cagagccaag 540
ctctccatct agtggacagg gaagctagca gcaaaccttc ccttcactac aaaacttcat 600
tgcttggcca aaaagagagt taattcaatg tagacatcta tgtaggcaat taaaaaccta 660
ttgatgtata aaacagtttg cattcatgga gggcaactaa atacattcta ggactttata 720
aaagatcact ttttatttat gcacagggtg gaacaagatg gattatcaag tgtcaagtcc 780
aatctatgac atcaattatt atacatcgga gccctgccaa aaaatcaatg tgaagcaaat 840
cgcagcccgc ctcctgcctc cgctctactc actggtgttc atctttggtt ttgtgggcaa 900
catgctggtc atcctcatcc tgataaactg caaaaggctg aagagcatga ctgacatcta 960
cctgctcaac ctggccatct ctgacctgtt tttccttctt actgtcccct tctgggctca 1020
ctatgctgcc gcccagtggg actttggaaa tacaatgtgt caacgaacag agaaacagga 1080
gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga 1140
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc 1200
ggctcagggc caagaacaga tggtccccag atgcggtccc gccctcagca gtttctagag 1260
aaccatcaga tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa 1320
ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctctatat 1380
aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 1440
cttccataga aggatctcga gatgtatcgg atgcagctct tgagctgtat cgctctgtca 1500
ctggcacttg ttaccaactc agaggatgac gttaccacca cggaagaact tgcgcccgct 1560
ttggtaccgc ctccgaaagg aacctgtgcc ggttggatgg ctggaatacc aggacatccc 1620
ggacacaatg gaacgccagg acgggatgga cgcgacggca cgcccggaga aaaaggggag 1680
aaaggggatg caggcttgct cgggccaaag ggcgaaaccg gcgacgttgg aatgacaggc 1740
gctgaaggac ctcggggttt tccgggaacc ccgggccgca agggcgaacc tggcgaggcc 1800
gccgcagtat tgacacagaa acagaaaaag caacattccg tccttcatct ggtccccatc 1860
aacgcaacct ccaaggatga tagtgatgtg accgaggtaa tgtggcaacc cgcgcttagg 1920
cgaggaagag gtctgcaggc gcagggatac ggggtgcgaa tccaagatgc tggggtgtac 1980
ctgctgtact cacaggtttt gtttcaggac gtaacattta cgatggggca ggtcgtgtcc 2040
cgagaaggac aagggagaca ggaaacactc ttccggtgta ttagaagtat gccttcacat 2100
cctgatcgcg cttacaactc ttgttattcc gctggcgtct ttcacttgca tcagggcgac 2160
atcctttcag tgataattcc gagagcgcgg gctaagttga atcttagccc ccacggcaca 2220
tttctcggat tcgtgaagct ttgatgagtc gactgcttta tttgtgaaat ttgtgatgct 2280
attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt 2340
cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaactct attttatagg 2400
cttcttctct ggaatcttct tcatcatcct cctgacaatc gataggtacc tggctgtcgt 2460
ccatgctgtg tttgctttaa aagccaggac ggtcaccttt ggggtggtga caagtgtgat 2520
cacttgggtg gtggctgtgt ttgcgtctct cccaggaatc atctttacca gatctcaaaa 2580
agaaggtctt cattacacct gcagctctca ttttccatac agtcagtatc aattctggaa 2640
gaatttccag acattaaaga tagtcatctt ggggctggtc ctgccgctgc ttgtcatggt 2700
catctgctac tcgggaatcc taaaaactct gcttcggtgt cgaaatgaga agaagaggca 2760
cagggctgtg aggcttatct tcaccatcat gattgtttat tttctcttct gggctcccta 2820
caacattgtc cttctcctga acaccttcca ggaattcttt ggcctgaata attgcagtag 2880
ctctaacagg ttggaccaag ctatgcaggt gacagagact cttgggatga cgcactgctg 2940
catcaacccc atcatctatg cctttgtcgg ggagaagttc agaaactacc tcttagtctt 3000
cttccaaaag cacattgcca aacgcttctg caaatgctgt tctattttcc agcaagaggc 3060
tcccgagcga gcaagctcag tttacacccg atccactggg gagcaggaaa tatctgtggg 3120
cttgtgacac ggactcaagt gggctggtga cccagtcaga gttgtgcaca tggcttagtt 3180
ttcatacaca ccgcggtcta gagcatggct acgtagataa gtagcatggc gggttaatca 3240
ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc 3300
tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag 3360
tgagcgagcg agcgcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc 3420
caacagttgc gcagcctgaa tggcgaatgg cgattccgtt gcaatggctg gcggtaatat 3480
tgttctggat attaccagca aggccgatag tttgagttct tctactcagg caagtgatgt 3540
tattactaat caaagaagta ttgcgacaac ggttaatttg cgtgatggac agactctttt 3600
actcggtggc ctcactgatt ataaaaacac ttctcaggat tctggcgtac cgttcctgtc 3660
taaaatccct ttaatcggcc tcctgtttag ctcccgctct gattctaacg aggaaagcac 3720
gttatacgtg ctcgtcaaag caaccatagt acgcgccctg tagcggcgca ttaagcgcgg 3780
cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc 3840
ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa 3900
atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac 3960
ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt 4020
tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca 4080
accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt 4140
taaaaaatga gctgatttaa caaaaattta acgcgaattt taacaaaata ttaacgttta 4200
caatttaaat atttgcttat acaatcttcc tgtttttggg gcttttctga ttatcaaccg 4260
gggtacatat gattgacatg ctagttttac gattaccgtt catcgattct cttgtttgct 4320
ccagactctc aggcaatgac ctgatagcct ttgtagagac ctctcaaaaa tagctaccct 4380
ctccggcatg aatttatcag ctagaacggt tgaatatcat attgatggtg atttgactgt 4440
ctccggcctt tctcacccgt ttgaatcttt acctacacat tactcaggca ttgcatttaa 4500
aatatatgag ggttctaaaa atttttatcc ttgcgttgaa ataaaggctt ctcccgcaaa 4560
agtattacag ggtcataatg tttttggtac aaccgattta gctttatgct ctgaggcttt 4620
attgcttaat tttgctaatt ctttgccttg cctgtatgat ttattggatg ttggaatcgc 4680
ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat atggtgcact 4740
ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc gccaacaccc 4800
gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc 4860
gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgagacga 4920
aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag 4980
acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa 5040
atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat 5100
tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg 5160
gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa 5220
gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt 5280
gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt 5340
ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat 5400
tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg 5460
acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta 5520
cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat 5580
catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag 5640
cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa 5700
ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca 5760
ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc 5820
ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt 5880
atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc 5940
gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat 6000
atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt 6060
tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac 6120
cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc 6180
ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca 6240
actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta 6300
gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct 6360
ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg 6420
gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc 6480
acacagccca gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta 6540
tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg 6600
gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt 6660
cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg 6720
cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg 6780
ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc 6840
gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg 6900
agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt 6960
cattaatg                                                          6968



<210> 60
<211> 7620
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAAV CCR5.MND.IL6.Frun.T2A.GFP

<400> 60
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tttggtgtgg tggcgcctgt agtccccagc cacttggagg ggtgaggtga gaggattgct 300
tgagcccggg atggtccagg ctgcagtgag ccatgatcgt gccactgcac tccagcctgg 360
gcgacagagt gagaccctgt ctcacaacaa caacaacaac aacaaaaagg ctgagctgca 420
ccatgcttga cccagtttct taaaattgtt gtcaaagctt cattcactcc atggtgctat 480
agagcacaag attttatttg gtgagatggt gctttcatga attcccccaa cagagccaag 540
ctctccatct agtggacagg gaagctagca gcaaaccttc ccttcactac aaaacttcat 600
tgcttggcca aaaagagagt taattcaatg tagacatcta tgtaggcaat taaaaaccta 660
ttgatgtata aaacagtttg cattcatgga gggcaactaa atacattcta ggactttata 720
aaagatcact ttttatttat gcacagggtg gaacaagatg gattatcaag tgtcaagtcc 780
aatctatgac atcaattatt atacatcgga gccctgccaa aaaatcaatg tgaagcaaat 840
cgcagcccgc ctcctgcctc cgctctactc actggtgttc atctttggtt ttgtgggcaa 900
catgctggtc atcctcatcc tgataaactg caaaaggctg aagagcatga ctgacatcta 960
cctgctcaac ctggccatct ctgacctgtt tttccttctt actgtcccct tctgggctca 1020
ctatgctgcc gcccagtggg actttggaaa tacaatgtgt caacgaacag agaaacagga 1080
gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga 1140
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc 1200
ggctcagggc caagaacaga tggtccccag atgcggtccc gccctcagca gtttctagag 1260
aaccatcaga tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa 1320
ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctctatat 1380
aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 1440
cttccataga aggatctcga gatgaacagt ttttctactt ctgccttcgg acccgtcgcc 1500
tttagcctgg gcctgctgct ggtgctgcct gccgcattcc ccgctcctgt gccccctgga 1560
gaagactcca aggatgtcgc cgctcctcac agacagccac tgactagctc cgagaggatc 1620
gacaaacaga tccgctacat tctggatggc attagcgccc tgcgcaagga aacctgcaac 1680
aaatccaata tgtgtgagtc tagtaaggaa gcactggccg agaacaatct gaacctgccc 1740
aagatggctg agaaagacgg ctgcttccag tctgggttta atgaggaaac ctgtctggtg 1800
aaaatcatta cagggctgct ggagttcgaa gtctacctgg aatatctgca gaaccgattt 1860
gagtcaagcg aggaacaggc tcgggcagtg cagatgagca caaaggtcct gatccagttc 1920
ctgcagaaga aagccaaaaa tctggacgct attaccacac cagatcccac taccaacgct 1980
tctctgctga ccaagctgca ggcacagaat cagtggctgc aggatatgac aactcacctg 2040
atcctgagga gtttcaaaga atttctgcag tcctctctgc gggcactgag acagatgcgc 2100
gctaagcgag gatccggtga gggcagagga agtcttctaa catgcggtga cgtggaggag 2160
aatccgggcc ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg 2220
gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc 2280
gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg 2340
ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc 2400
gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag 2460
cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag 2520
ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac 2580
atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac 2640
aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc 2700
gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg 2760
cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc 2820
gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag 2880
ctgtacaagt gaatctagag tcgactgctt tatttgtgaa atttgtgatg ctattgcttt 2940
atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat 3000
gtttcaggtt cagggggagg tgtgggaggt tttttaaact ctattttata ggcttcttct 3060
ctggaatctt cttcatcatc ctcctgacaa tcgataggta cctggctgtc gtccatgctg 3120
tgtttgcttt aaaagccagg acggtcacct ttggggtggt gacaagtgtg atcacttggg 3180
tggtggctgt gtttgcgtct ctcccaggaa tcatctttac cagatctcaa aaagaaggtc 3240
ttcattacac ctgcagctct cattttccat acagtcagta tcaattctgg aagaatttcc 3300
agacattaaa gatagtcatc ttggggctgg tcctgccgct gcttgtcatg gtcatctgct 3360
actcgggaat cctaaaaact ctgcttcggt gtcgaaatga gaagaagagg cacagggctg 3420
tgaggcttat cttcaccatc atgattgttt attttctctt ctgggctccc tacaacattg 3480
tccttctcct gaacaccttc caggaattct ttggcctgaa taattgcagt agctctaaca 3540
ggttggacca agctatgcag gtgacagaga ctcttgggat gacgcactgc tgcatcaacc 3600
ccatcatcta tgcctttgtc ggggagaagt tcagaaacta cctcttagtc ttcttccaaa 3660
agcacattgc caaacgcttc tgcaaatgct gttctatttt ccagcaagag gctcccgagc 3720
gagcaagctc agtttacacc cgatccactg gggagcagga aatatctgtg ggcttgtgac 3780
acggactcaa gtgggctggt gacccagtca gagttgtgca catggcttag ttttcataca 3840
caccgcggtc tagagcatgg ctacgtagat aagtagcatg gcgggttaat cattaactac 3900
aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag 3960
gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag 4020
cgagcgcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt 4080
gcgcagcctg aatggcgaat ggcgattccg ttgcaatggc tggcggtaat attgttctgg 4140
atattaccag caaggccgat agtttgagtt cttctactca ggcaagtgat gttattacta 4200
atcaaagaag tattgcgaca acggttaatt tgcgtgatgg acagactctt ttactcggtg 4260
gcctcactga ttataaaaac acttctcagg attctggcgt accgttcctg tctaaaatcc 4320
ctttaatcgg cctcctgttt agctcccgct ctgattctaa cgaggaaagc acgttatacg 4380
tgctcgtcaa agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg 4440
gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct 4500
ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg 4560
ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag 4620
ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg 4680
gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc 4740
tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat 4800
gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttaa 4860
atatttgctt atacaatctt cctgtttttg gggcttttct gattatcaac cggggtacat 4920
atgattgaca tgctagtttt acgattaccg ttcatcgatt ctcttgtttg ctccagactc 4980
tcaggcaatg acctgatagc ctttgtagag acctctcaaa aatagctacc ctctccggca 5040
tgaatttatc agctagaacg gttgaatatc atattgatgg tgatttgact gtctccggcc 5100
tttctcaccc gtttgaatct ttacctacac attactcagg cattgcattt aaaatatatg 5160
agggttctaa aaatttttat ccttgcgttg aaataaaggc ttctcccgca aaagtattac 5220
agggtcataa tgtttttggt acaaccgatt tagctttatg ctctgaggct ttattgctta 5280
attttgctaa ttctttgcct tgcctgtatg atttattgga tgttggaatc gcctgatgcg 5340
gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatggtgca ctctcagtac 5400
aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc 5460
gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg 5520
gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct 5580
cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg 5640
tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc 5700
aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag 5760
gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg 5820
ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt 5880
gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt 5940
tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt 6000
attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa 6060
tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag 6120
agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac 6180
aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac 6240
tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac 6300
cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac 6360
tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact 6420
tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg 6480
tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt 6540
tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat 6600
aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta 6660
gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa 6720
tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga 6780
aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac 6840
aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt 6900
tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc 6960
gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat 7020
cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag 7080
acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc 7140
cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag 7200
cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac 7260
aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg 7320
gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct 7380
atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc 7440
tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga 7500
gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga 7560
agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg 7620




<210> 61
<211> 7764
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAAV CCR5.MND.II2ss-ADP.mAPRIL.Furin.T2A.GFP

<400> 61
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tttggtgtgg tggcgcctgt agtccccagc cacttggagg ggtgaggtga gaggattgct 300
tgagcccggg atggtccagg ctgcagtgag ccatgatcgt gccactgcac tccagcctgg 360
gcgacagagt gagaccctgt ctcacaacaa caacaacaac aacaaaaagg ctgagctgca 420
ccatgcttga cccagtttct taaaattgtt gtcaaagctt cattcactcc atggtgctat 480
agagcacaag attttatttg gtgagatggt gctttcatga attcccccaa cagagccaag 540
ctctccatct agtggacagg gaagctagca gcaaaccttc ccttcactac aaaacttcat 600
tgcttggcca aaaagagagt taattcaatg tagacatcta tgtaggcaat taaaaaccta 660
ttgatgtata aaacagtttg cattcatgga gggcaactaa atacattcta ggactttata 720
aaagatcact ttttatttat gcacagggtg gaacaagatg gattatcaag tgtcaagtcc 780
aatctatgac atcaattatt atacatcgga gccctgccaa aaaatcaatg tgaagcaaat 840
cgcagcccgc ctcctgcctc cgctctactc actggtgttc atctttggtt ttgtgggcaa 900
catgctggtc atcctcatcc tgataaactg caaaaggctg aagagcatga ctgacatcta 960
cctgctcaac ctggccatct ctgacctgtt tttccttctt actgtcccct tctgggctca 1020
ctatgctgcc gcccagtggg actttggaaa tacaatgtgt caacgaacag agaaacagga 1080
gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga 1140
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc 1200
ggctcagggc caagaacaga tggtccccag atgcggtccc gccctcagca gtttctagag 1260
aaccatcaga tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa 1320
ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctctatat 1380
aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 1440
cttccataga aggatctcga gatgtatcgg atgcagctct tgagctgtat cgctctgtca 1500
ctggcacttg ttaccaactc agaggatgac gttaccacca cggaagaact tgcgcccgct 1560
ttggtaccgc ctccgaaagg aacctgtgcc ggttggatgg ctggaatacc aggacatccc 1620
ggacacaatg gaacgccagg acgggatgga cgcgacggca cgcccggaga aaaaggggag 1680
aaaggggatg caggcttgct cgggccaaag ggcgaaaccg gcgacgttgg aatgacaggc 1740
gctgaaggac ctcggggttt tccgggaacc ccgggccgca agggcgaacc tggcgaggcc 1800
gccgcagtat tgacacagaa acagaaaaag caacattccg tccttcatct ggtccccatc 1860
aacgcaacct ccaaggatga tagtgatgtg accgaggtaa tgtggcaacc cgcgcttagg 1920
cgaggaagag gtctgcaggc gcagggatac ggggtgcgaa tccaagatgc tggggtgtac 1980
ctgctgtact cacaggtttt gtttcaggac gtaacattta cgatggggca ggtcgtgtcc 2040
cgagaaggac aagggagaca ggaaacactc ttccggtgta ttagaagtat gccttcacat 2100
cctgatcgcg cttacaactc ttgttattcc gctggcgtct ttcacttgca tcagggcgac 2160
atcctttcag tgataattcc gagagcgcgg gctaagttga atcttagccc ccacggcaca 2220
tttctcggat tcgtgaagct tcgcgctaag cgaggatccg gtgagggcag aggaagtctt 2280
ctaacatgcg gtgacgtgga ggagaatccg ggccccatgg tgagcaaggg cgaggagctg 2340
ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc 2400
agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc 2460
tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc 2520
gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc 2580
atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag 2640
acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc 2700
atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc 2760
cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc 2820
cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc 2880
atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg 2940
agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc 3000
gggatcactc tcggcatgga cgagctgtac aagtgaatct agagtcgact gctttatttg 3060
tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa 3120
caacaacaat tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta 3180
aactctattt tataggcttc ttctctggaa tcttcttcat catcctcctg acaatcgata 3240
ggtacctggc tgtcgtccat gctgtgtttg ctttaaaagc caggacggtc acctttgggg 3300
tggtgacaag tgtgatcact tgggtggtgg ctgtgtttgc gtctctccca ggaatcatct 3360
ttaccagatc tcaaaaagaa ggtcttcatt acacctgcag ctctcatttt ccatacagtc 3420
agtatcaatt ctggaagaat ttccagacat taaagatagt catcttgggg ctggtcctgc 3480
cgctgcttgt catggtcatc tgctactcgg gaatcctaaa aactctgctt cggtgtcgaa 3540
atgagaagaa gaggcacagg gctgtgaggc ttatcttcac catcatgatt gtttattttc 3600
tcttctgggc tccctacaac attgtccttc tcctgaacac cttccaggaa ttctttggcc 3660
tgaataattg cagtagctct aacaggttgg accaagctat gcaggtgaca gagactcttg 3720
ggatgacgca ctgctgcatc aaccccatca tctatgcctt tgtcggggag aagttcagaa 3780
actacctctt agtcttcttc caaaagcaca ttgccaaacg cttctgcaaa tgctgttcta 3840
ttttccagca agaggctccc gagcgagcaa gctcagttta cacccgatcc actggggagc 3900
aggaaatatc tgtgggcttg tgacacggac tcaagtgggc tggtgaccca gtcagagttg 3960
tgcacatggc ttagttttca tacacaccgc ggtctagagc atggctacgt agataagtag 4020
catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct 4080
ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt 4140
gcccgggcgg cctcagtgag cgagcgagcg cgccagctgg cgtaatagcg aagaggcccg 4200
caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatggcgat tccgttgcaa 4260
tggctggcgg taatattgtt ctggatatta ccagcaaggc cgatagtttg agttcttcta 4320
ctcaggcaag tgatgttatt actaatcaaa gaagtattgc gacaacggtt aatttgcgtg 4380
atggacagac tcttttactc ggtggcctca ctgattataa aaacacttct caggattctg 4440
gcgtaccgtt cctgtctaaa atccctttaa tcggcctcct gtttagctcc cgctctgatt 4500
ctaacgagga aagcacgtta tacgtgctcg tcaaagcaac catagtacgc gccctgtagc 4560
ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc 4620
gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt 4680
ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac 4740
ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag 4800
acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa 4860
actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg 4920
atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac 4980
aaaatattaa cgtttacaat ttaaatattt gcttatacaa tcttcctgtt tttggggctt 5040
ttctgattat caaccggggt acatatgatt gacatgctag ttttacgatt accgttcatc 5100
gattctcttg tttgctccag actctcaggc aatgacctga tagcctttgt agagacctct 5160
caaaaatagc taccctctcc ggcatgaatt tatcagctag aacggttgaa tatcatattg 5220
atggtgattt gactgtctcc ggcctttctc acccgtttga atctttacct acacattact 5280
caggcattgc atttaaaata tatgagggtt ctaaaaattt ttatccttgc gttgaaataa 5340
aggcttctcc cgcaaaagta ttacagggtc ataatgtttt tggtacaacc gatttagctt 5400
tatgctctga ggctttattg cttaattttg ctaattcttt gccttgcctg tatgatttat 5460
tggatgttgg aatcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca 5520
ccgcatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg 5580
acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta 5640
cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc 5700
gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat 5760
aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat 5820
ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata 5880
aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct 5940
tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa 6000
agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa 6060
cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt 6120
taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg 6180
tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca 6240
tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa 6300
cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt 6360
gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc 6420
cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa 6480
actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga 6540
ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc 6600
tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga 6660
tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga 6720
acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga 6780
ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat 6840
ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt 6900
ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct 6960
gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc 7020
ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc 7080
aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc 7140
gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc 7200
gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg 7260
aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata 7320
cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta 7380
tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc 7440
ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg 7500
atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt 7560
cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt 7620
ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga 7680
gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc 7740
cgcgcgttgg ccgattcatt aatg                                        7764



<210> 62
<211> 6821
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAAV CCR5 MND IL6

<400> 62
cagctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc 60
tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc caactccatc 120
actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac gtagccatgc 180
tctagcggcc tcggcctctg cataaataaa aaaaattagt cagccatgag cttggacgcg 240
tttggtgtgg tggcgcctgt agtccccagc cacttggagg ggtgaggtga gaggattgct 300
tgagcccggg atggtccagg ctgcagtgag ccatgatcgt gccactgcac tccagcctgg 360
gcgacagagt gagaccctgt ctcacaacaa caacaacaac aacaaaaagg ctgagctgca 420
ccatgcttga cccagtttct taaaattgtt gtcaaagctt cattcactcc atggtgctat 480
agagcacaag attttatttg gtgagatggt gctttcatga attcccccaa cagagccaag 540
ctctccatct agtggacagg gaagctagca gcaaaccttc ccttcactac aaaacttcat 600
tgcttggcca aaaagagagt taattcaatg tagacatcta tgtaggcaat taaaaaccta 660
ttgatgtata aaacagtttg cattcatgga gggcaactaa atacattcta ggactttata 720
aaagatcact ttttatttat gcacagggtg gaacaagatg gattatcaag tgtcaagtcc 780
aatctatgac atcaattatt atacatcgga gccctgccaa aaaatcaatg tgaagcaaat 840
cgcagcccgc ctcctgcctc cgctctactc actggtgttc atctttggtt ttgtgggcaa 900
catgctggtc atcctcatcc tgataaactg caaaaggctg aagagcatga ctgacatcta 960
cctgctcaac ctggccatct ctgacctgtt tttccttctt actgtcccct tctgggctca 1020
ctatgctgcc gcccagtggg actttggaaa tacaatgtgt caacgaacag agaaacagga 1080
gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga 1140
acagttggaa cagcagaata tgggccaaac aggatatctg tggtaagcag ttcctgcccc 1200
ggctcagggc caagaacaga tggtccccag atgcggtccc gccctcagca gtttctagag 1260
aaccatcaga tgtttccagg gtgccccaag gacctgaaat gaccctgtgc cttatttgaa 1320
ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt ctgctccccg agctctatat 1380
aagcagagct cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga 1440
cttccataga aggatctcga gatgaacagt ttttctactt ctgccttcgg acccgtcgcc 1500
tttagcctgg gcctgctgct ggtgctgcct gccgcattcc ccgctcctgt gccccctgga 1560
gaagactcca aggatgtcgc cgctcctcac agacagccac tgactagctc cgagaggatc 1620
gacaaacaga tccgctacat tctggatggc attagcgccc tgcgcaagga aacctgcaac 1680
aaatccaata tgtgtgagtc tagtaaggaa gcactggccg agaacaatct gaacctgccc 1740
aagatggctg agaaagacgg ctgcttccag tctgggttta atgaggaaac ctgtctggtg 1800
aaaatcatta cagggctgct ggagttcgaa gtctacctgg aatatctgca gaaccgattt 1860
gagtcaagcg aggaacaggc tcgggcagtg cagatgagca caaaggtcct gatccagttc 1920
ctgcagaaga aagccaaaaa tctggacgct attaccacac cagatcccac taccaacgct 1980
tctctgctga ccaagctgca ggcacagaat cagtggctgc aggatatgac aactcacctg 2040
atcctgagga gtttcaaaga atttctgcag tcctctctgc gggcactgag acagatgtga 2100
gtcgactgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc 2160
tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag 2220
gtgtgggagg ttttttaaac tctattttat aggcttcttc tctggaatct tcttcatcat 2280
cctcctgaca atcgataggt acctggctgt cgtccatgct gtgtttgctt taaaagccag 2340
gacggtcacc tttggggtgg tgacaagtgt gatcacttgg gtggtggctg tgtttgcgtc 2400
tctcccagga atcatcttta ccagatctca aaaagaaggt cttcattaca cctgcagctc 2460
tcattttcca tacagtcagt atcaattctg gaagaatttc cagacattaa agatagtcat 2520
cttggggctg gtcctgccgc tgcttgtcat ggtcatctgc tactcgggaa tcctaaaaac 2580
tctgcttcgg tgtcgaaatg agaagaagag gcacagggct gtgaggctta tcttcaccat 2640
catgattgtt tattttctct tctgggctcc ctacaacatt gtccttctcc tgaacacctt 2700
ccaggaattc tttggcctga ataattgcag tagctctaac aggttggacc aagctatgca 2760
ggtgacagag actcttggga tgacgcactg ctgcatcaac cccatcatct atgcctttgt 2820
cggggagaag ttcagaaact acctcttagt cttcttccaa aagcacattg ccaaacgctt 2880
ctgcaaatgc tgttctattt tccagcaaga ggctcccgag cgagcaagct cagtttacac 2940
ccgatccact ggggagcagg aaatatctgt gggcttgtga cacggactca agtgggctgg 3000
tgacccagtc agagttgtgc acatggctta gttttcatac acaccgcggt ctagagcatg 3060
gctacgtaga taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg 3120
agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg 3180
cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc cagctggcgt 3240
aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa 3300
tggcgattcc gttgcaatgg ctggcggtaa tattgttctg gatattacca gcaaggccga 3360
tagtttgagt tcttctactc aggcaagtga tgttattact aatcaaagaa gtattgcgac 3420
aacggttaat ttgcgtgatg gacagactct tttactcggt ggcctcactg attataaaaa 3480
cacttctcag gattctggcg taccgttcct gtctaaaatc cctttaatcg gcctcctgtt 3540
tagctcccgc tctgattcta acgaggaaag cacgttatac gtgctcgtca aagcaaccat 3600
agtacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga 3660
ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg 3720
ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat 3780
ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg 3840
ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata 3900
gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt 3960
tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat 4020
ttaacgcgaa ttttaacaaa atattaacgt ttacaattta aatatttgct tatacaatct 4080
tcctgttttt ggggcttttc tgattatcaa ccggggtaca tatgattgac atgctagttt 4140
tacgattacc gttcatcgat tctcttgttt gctccagact ctcaggcaat gacctgatag 4200
cctttgtaga gacctctcaa aaatagctac cctctccggc atgaatttat cagctagaac 4260
ggttgaatat catattgatg gtgatttgac tgtctccggc ctttctcacc cgtttgaatc 4320
tttacctaca cattactcag gcattgcatt taaaatatat gagggttcta aaaattttta 4380
tccttgcgtt gaaataaagg cttctcccgc aaaagtatta cagggtcata atgtttttgg 4440
tacaaccgat ttagctttat gctctgaggc tttattgctt aattttgcta attctttgcc 4500
ttgcctgtat gatttattgg atgttggaat cgcctgatgc ggtattttct ccttacgcat 4560
ctgtgcggta tttcacaccg catatggtgc actctcagta caatctgctc tgatgccgca 4620
tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg 4680
ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg 4740
ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta 4800
taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat 4860
gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg 4920
agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa 4980
catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac 5040
ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac 5100
atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt 5160
ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc 5220
gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca 5280
ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc 5340
ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag 5400
gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa 5460
ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg 5520
gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa 5580
ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg 5640
gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt 5700
gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt 5760
caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag 5820
cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat 5880
ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct 5940
taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 6000
tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca 6060
gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc 6120
agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc 6180
aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct 6240
gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag 6300
gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 6360
tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg 6420
agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag 6480
cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt 6540
gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac 6600
gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg 6660
ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc 6720
cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcccaata 6780
cgcaaaccgc ctctccccgc gcgttggccg attcattaat g                     6821



<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense to exon 1 Guide Sequence RNA (Jchain)

<400> 63
ggactcccca gaaaagcaaa                                             20

<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense to exon 1 Guide Sequence RNA (Jchain)

<400> 64
aagaaccatt tgcttttctg                                             20

<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense to exon 1 Guide Sequence RNA (Jchain)

<400> 65
tttgcttttc tggggagtcc                                             20

<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense to exon 1 Guide Sequence RNA (Jchain)

<400> 66
attaaggctg ttcatgtgaa                                             20

<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense  to exon 1 Guide Sequence RNA (Jchain)

<400> 67
ccggcgcggc aggcgcatgg                                             20

<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense to exon 1 Guide Sequence RNA (Jchain)

<400> 68
agccccagcg cggcccggcg                                             20

<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense to exon 1 Guide Sequence RNA (CRELD2)

<400> 69
tgccgcgccg ggccgcgctg                                             20

<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense to exon 1 Guide Sequence RNA CRELD2

<400> 70
aagcggcagg agccccagcg                                             20

<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense to exon 2 Guide Sequence RNA (BCL2L11)

<400> 71
aggtagacaa ttgcagcctg                                             20

<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense to exon 2 Guide Sequence RNA (BCL2L11)

<400> 72
tccctacaga cagagccaca                                             20

<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense to exon 2 Guide Sequence RNA (SLPI-2sense)

<400> 73
agatgttgtc ctgacacttg                                             20

<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense to exon 1 Guide Sequence RNA (SLPI-2sense)

<400> 74
gccttcacca tgaagtccag                                             20

<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense Guide Sequence RNA (IGKC-sense)

<400> 75
ttcaactgct catcagatgg                                             20

<210> 76
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense Guide Sequence RNA (IGKC-anti sense)

<400> 76
ggccaaagta cagtggaagg                                             20

<210> 77

<400> 77
 000

<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense Guide Sequence RNA (IGKC-sense)

<400> 78
cacgctgctc gtatccgacg                                             20

<210> 79
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense Guide Sequence RNA( IGKC-antisense)

<400> 79
ccttccaagg acgtcatgca                                             20

<210> 80
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense to exon 1Guide Sequence RNA
      (JCHAIN-1-antisense)

<400> 80
cagccttaat aaaaaccgcc                                             20

<210> 81
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense  to exon 2 guide sequence RNA
      (JCHAIN-2-sense)

<400> 81
ttcttccgaa gatcctaatg                                             20

<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense  to exon 4 guide sequence RNA
      (JCHAIN-4-antisense)

<400> 82
gtcaggatag caggcatctg                                             20

<210> 83
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense to exon 2 guide sequence RNA
      (PON3-2antisense)

<400> 83
tactggctcc acttctcgag                                             20

<210> 84
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense to exon 3 guide sequence RNA (PON3-3sense)

<400> 84
gatattgata tacttcctag                                             20

<210> 85
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense to exon 3 guide sequence RNA
      (PRG2-3antisense)

<400> 85
acccaaaggg gtctcaaagg                                             20

<210> 86
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense to exon 3 guide sequence RNA
      (PRG2-3antisense)

<400> 86
cagcgtctta gcacccaaag                                             20

<210> 87
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> sense to exon 3 guide sequence RNA (CRELD2-3sense)

<400> 87
cgaatgcaat cagatgctag                                             20

<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense  to exon 4 guide sequence RNA
      CRELD2-4antisense

<400> 88
accgagacag tcgggaccgt                                             20

<210> 89
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> JCHAIN Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 2, 34
<223> gm

<220> 
<221> modified_base  
<222> 3
<223> m2a

<220> 
<221> modified_base  
<222> 35
<223> cm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 89
ggacucccca gaaaagcaaa guuuuagagc uaugcu                           36

<210> 90
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> JCHAIN Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 2
<223> m2a

<220> 
<221> modified_base  
<222> 3, 34
<223> gm

<220> 
<221> modified_base  
<222> 35
<223> cm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 90
aagaaccauu ugcuuuucug guuuuagagc uaugcu                           36

<210> 91
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> JCHAIN Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1-3, 36
<223> um

<220> 
<221> modified_base  
<222> 34
<223> gm

<220> 
<221> modified_base  
<222> 35
<223> cm

<400> 91
uuugcuuuuc uggggagucc guuuuagagc uaugcu                           36

<210> 92
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> JCHAIN Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1
<223> m2a

<220> 
<221> modified_base  
<222> 2, 3, 36
<223> um

<220> 
<221> modified_base  
<222> 34
<223> gm

<220> 
<221> modified_base  
<222> 35
<223> cm

<400> 92
auuaaggcug uucaugugaa guuuuagagc uaugcu                           36

<210> 93
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> CRELD2 Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 2, 35
<223> cm

<220> 
<221> modified_base  
<222> 3, 34
<223> gm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 93
ccggcgcggc aggcgcaugg guuuuagagc uaugcu                           36

<210> 94
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> CRELD2 Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1
<223> m2a

<220> 
<221> modified_base  
<222> 2, 34
<223> gm

<220> 
<221> modified_base  
<222> 3, 35
<223> cm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 94
agccccagcg cggcccggcg guuuuagagc uaugcu                           36

<210> 95
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> CRELD2 Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 36
<223> um

<220> 
<221> modified_base  
<222> 2, 34
<223> gm

<220> 
<221> modified_base  
<222> 3, 35
<223> cm

<400> 95
ugccgcgccg ggccgcgcug guuuuagagc uaugcu                           36

<210> 96
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> CRELD2 Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 2
<223> m2a

<220> 
<221> modified_base  
<222> 3, 34
<223> gm

<220> 
<221> modified_base  
<222> 35
<223> cm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 96
aagcggcagg agccccagcg guuuuagagc uaugcu                           36

<210> 97
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> BCL2L11 Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1
<223> m2a

<220> 
<221> modified_base  
<222> 2, 3, 34
<223> gm

<220> 
<221> modified_base  
<222> 35
<223> cm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 97
agguagacaa uugcagccug guuuuagagc uaugcu                           36

<210> 98
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> BCL2L11 Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 36
<223> um

<220> 
<221> modified_base  
<222> 2, 3, 35
<223> cm

<220> 
<221> modified_base  
<222> 34
<223> gm

<400> 98
ucccuacaga cagagccaca guuuuagagc uaugcu                           36

<210> 99
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> SLPI-2sense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 3
<223> m2a

<220> 
<221> modified_base  
<222> 2, 34
<223> gm

<220> 
<221> modified_base  
<222> 35
<223> cm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 99
agauguuguc cugacacuug guuuuagagc uaugcu                           36

<210> 100
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> SLPI-1sense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 34
<223> gm

<220> 
<221> modified_base  
<222> 2, 3, 35
<223> cm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 100
gccuucacca ugaaguccag guuuuagagc uaugcu                           36

<210> 101
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> IGKC-sense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 2, 36
<223> um

<220> 
<221> modified_base  
<222> 3, 35
<223> cm

<220> 
<221> modified_base  
<222> 34
<223> gm

<400> 101
uucaacugcu caucagaugg guuuuagagc uaugcu                           36

<210> 102
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> IGKC-antisense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 2, 34
<223> gm

<220> 
<221> modified_base  
<222> 3, 35
<223> cm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 102
ggccaaagua caguggaagg guuuuagagc uaugcu                           36

<210> 103
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> IGMC-sense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 3, 35
<223> cm

<220> 
<221> modified_base  
<222> 2
<223> m2a

<220> 
<221> modified_base  
<222> 34
<223> gm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 103
cacgcugcuc guauccgacg guuuuagagc uaugcu                           36

<210> 104
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> IGMC-antisense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 2, 35
<223> cm

<220> 
<221> modified_base  
<222> 3, 36
<223> um

<220> 
<221> modified_base  
<222> 34
<223> gm

<400> 104
ccuuccaagg acgucaugca guuuuagagc uaugcu                           36

<210> 105
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> JCHAIN-1antisense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 35
<223> cm

<220> 
<221> modified_base  
<222> 2
<223> m2a

<220> 
<221> modified_base  
<222> 3, 34
<223> gm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 105
cagccuuaau aaaaaccgcc guuuuagagc uaugcu                           36

<210> 106
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> JCHAIN2-sense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 2, 36
<223> um

<220> 
<221> modified_base  
<222> 3, 35
<223> cm

<220> 
<221> modified_base  
<222> 34
<223> gm

<400> 106
uucuuccgaa gauccuaaug guuuuagagc uaugcu                           36

<210> 107
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> JCHAIN-4antisense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 34
<223> gm

<220> 
<221> modified_base  
<222> 2, 36
<223> um

<220> 
<221> modified_base  
<222> 3, 35
<223> cm

<400> 107
gucaggauag caggcaucug guuuuagagc uaugcu                           36

<210> 108
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> PON3-2antisense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 36
<223> um

<220> 
<221> modified_base  
<222> 2
<223> m2a

<220> 
<221> modified_base  
<222> 3, 35
<223> cm

<220> 
<221> modified_base  
<222> 34
<223> gm

<400> 108
uacuggcucc acuucucgag guuuuagagc uaugcu                           36

<210> 109
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> PON3-3sense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 34
<223> gm

<220> 
<221> modified_base  
<222> 2
<223> m2a

<220> 
<221> modified_base  
<222> 3, 36
<223> um

<220> 
<221> modified_base  
<222> 35
<223> cm

<400> 109
gauauugaua uacuuccuag guuuuagagc uaugcu                           36

<210> 110
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> PRG2-3antisense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1
<223> m2a

<220> 
<221> modified_base  
<222> 2, 3, 35
<223> cm

<220> 
<221> modified_base  
<222> 34
<223> gm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 110
acccaaaggg gucucaaagg guuuuagagc uaugcu                           36

<210> 111
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> PRG2-3antisense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 35
<223> cm

<220> 
<221> modified_base  
<222> 2
<223> m2a

<220> 
<221> modified_base  
<222> 3, 34
<223> gm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 111
cagcgucuua gcacccaaag guuuuagagc uaugcu                           36

<210> 112
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> CRELD2-3sense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1, 35
<223> cm

<220> 
<221> modified_base  
<222> 2, 34
<223> gm

<220> 
<221> modified_base  
<222> 3
<223> m2a

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 112
cgaaugcaau cagaugcuag guuuuagagc uaugcu                           36

<210> 113
<211> 36
<212> RNA
<213> Artificial Sequence

<220> 
<223> CRELD2-4antisense Guide sequence - mod & linker

<220> 
<221> modified_base  
<222> 1
<223> m2a

<220> 
<221> modified_base  
<222> 2, 3, 35
<223> cm

<220> 
<221> modified_base  
<222> 34
<223> gm

<220> 
<221> modified_base  
<222> 36
<223> um

<400> 113
accgagacag ucgggaccgu guuuuagagc uaugcu                           36
