                         SEQUENCE LISTING

<110>  Ohio State Innovation Foundation
 
<120>  METHODS AND COMPOSITIONS RELATED TO A TISSUE FACTOR-TARGETING 
       IgG3 IMMUNOCONJUGATES

<130>  10336-305WO1

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
aagcttgaat tcgccaccat ggtctcccag gccctcaggc tcctctgcct tctgcttggg       60

cttcagggct gcctggctgc agtcttcgta acccaggagg aagcccacgg cgtcctgcac      120

ggcgccggcg cgccaacgcg ttcctggagg agctgcggcc gggctccctg gagagggagt      180

gcaaggagga gcagtgctcc ttcgaggagg cccgggagat cttcaaggac gcggagagga      240

cgaagctgtt ctggatttct tacagtgatg gtgaccagtg tgcctcaagt ccatgccaga      300

atgggggctc ctgcaaggac cagctccagt cctatatctg cttctgcctc cctgccttcg      360

agggccggaa ctgtgagacg cacaaggatg accagctgat ctgtgtgaac gagaacggcg      420

gctgtgagca gtactgcagt gaccacacgg gcaccaagcg ctcctgtcgg tgccacgagg      480

ggtactctct gctggcagac ggggtgtcct gcacacccac agttgaatat ccatgtggaa      540

aaatacctat tctagaaaaa agaaatgcca gcaagcccca agggcgagga tccgacacac      600

ctcccccgtg cccaaggtgc ccagcacctg aactcctggg aggaccgtca gtcttcctct      660

tccccccaaa acccaaggat acccttatga tttcccggac ccctgaggtc acgtgcgtgg      720

tggtggacgt gagccacgaa gaccccgagg tccagttcaa gtggtacgtg gacggcgtgg      780

aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg ttccgtgtgg      840

tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac aagtgcaagg      900

tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaaacc aaaggacagc      960

cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg     1020

tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga     1080

gcagcgggca gccggagaac aactacaaca ccacgcctcc catgctggac tccgacggct     1140

ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacatct     1200

tctcatgctc cgtgatgcat gaggctctgc acaaccgctt cacgcagaag agcctctccc     1260

tgtctccggg taaatgagcg gccgc                                           1285


<210>  2
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Ser 
            180                 185                 190         


Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly 
        195                 200                 205             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    210                 215                 220                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
225                 230                 235                 240 


Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val 
                245                 250                 255     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe 
            260                 265                 270         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        275                 280                 285             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    290                 295                 300                 


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
305                 310                 315                 320 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                325                 330                 335     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            340                 345                 350         


Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro 
        355                 360                 365             


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    370                 375                 380                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met 
385                 390                 395                 400 


His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Lys 
            


<210>  3
<211>  2051
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
aagctttgca gagatttcat catggtctcc caggccctca ggctcctctg ccttctgctt       60

gggcttcagg gctgcctggc tgcagtcttc gtaacccagg aggaagccca cggcgtcctg      120

caccggcgcc ggcgcgccaa cgcgttcctg gaggagctgc ggccgggctc cctggagagg      180

gagtgcaagg aggagcagtg ctccttcgag gaggcccggg agatcttcaa ggacgcggag      240

aggacgaagc tgttctggat ttcttacagt gatggtgacc agtgtgcctc aagtccatgc      300

cagaatgggg gctcctgcaa ggaccagctc cagtcctata tctgcttctg cctccctgcc      360

ttcgagggcc ggaactgtga gacgcacaag gatgaccagc tgatctgtgt gaacgagaac      420

ggcggctgtg agcagtactg cagtgaccac acgggcacca agcgctcctg tcggtgccac      480

gaggggtact ctctgctggc agacggggtg tcctgcacac ccacagttga atatccatgt      540

ggaaaaatac ctattctaga aaaaagaaat gccagcaagc cccaagggcg aattgtgggg      600

ggcaaggtgt gccccaaagg ggagtgtcca tggcaggtcc tgttgttggt gaatggagct      660

cagttgtgtg gggggaccct gatcaacacc atctgggtgg tctccgcggc ccactgtttc      720

gacaaaatca agaactggag gaacctgatc gcggtgctcg gggagcacga cctcagcgag      780

cacgacgggg atgagcagag ccggcgggtg gcgcaggtca tcatccccag cacgtacgtc      840

ccgggcacca ccaaccacga catcgcgctg ctccgcctgc accagcccgt ggtcctcact      900

gaccatgtgg tgcccctctg cctgcccgaa cggacgttct ctgagaggac gctggccttc      960

gtgcgcttct cattggtcag cggctggggc cagctgctgg accgtggcgc cacggccctg     1020

gagctcatgg tcctcaacgt gccccggctg atgacccagg actgcctgca gcagtcacgg     1080

aaggtgggag actccccaaa tatcacggag tacatgttct gtgccggcta ctcggatggc     1140

agcaaggact cctgcgcggg ggacagtgga ggcccacatg ccacccacta ccggggcacg     1200

tggtacctga cgggcatcgt cagctggggc cagggctgcg caaccgtggg ccactttggg     1260

gtgtacacca gggtctccca gtacatcgag tggctgcaaa agctcatgcg ctcagagcca     1320

cgcccaggag tcctcctgcg agccccattt cccggatccg acacacctcc cccgtgccca     1380

aggtgcccag cacctgaact cctgggagga ccgtcagtct tcctcttccc cccaaaaccc     1440

aaggataccc ttatgatttc ccggacccct gaggtcacgt gcgtggtggt ggacgtgagc     1500

cacgaagacc ccgaggtcca gttcaagtgg tacgtggacg gcgtggaggt gcataatgcc     1560

aagacaaagc cgcgggagga gcagtacaac agcacgttcc gtgtggtcag cgtcctcacc     1620

gtcctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtctc caacaaagcc     1680

ctcccagccc ccatcgagaa aaccatctcc aaaaccaaag gacagccccg agaaccacag     1740

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1800

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcag cgggcagccg     1860

gagaacaact acaacaccac gcctcccatg ctggactccg acggctcctt cttcctctac     1920

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acatcttctc atgctccgtg     1980

atgcatgagg ctctgcacaa ccgcttcacg cagaagagcc tctccctgtc tccgggtaaa     2040

tgagcggccg c                                                          2051


<210>  4
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Ser Asp Thr 
        435                 440                 445             


Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    450                 455                 460                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
465                 470                 475                 480 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                485                 490                 495     


Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn 
            500                 505                 510         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val 
        515                 520                 525             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    530                 535                 540                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
545                 550                 555                 560 


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                565                 570                 575     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            580                 585                 590         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        595                 600                 605             


Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu 
    610                 615                 620                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
625                 630                 635                 640 


Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu 
                645                 650                 655     


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            660                 665                 670         


Lys 
    


<210>  5
<211>  1286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
aagcttgaat tcgccaccat ggtctcccag gccctcaggc tcctctgcct tctgcttggg       60

cttcagggct gcctggctgc agtcttcgta acccaggagg aagcccacgg cgtcctgcac      120

cggcgccggc gcgccaacgc gttcctggag gagctgcggc cgggctccct ggagagggag      180

tgcaaggagg agcagtgctc cttcgaggag gcccgggaga tcttcaagga cgcggagagg      240

acgaagctgt tctggatttc ttacagtgat ggtgaccagt gtgcctcaag tccatgccag      300

aatgggggct cctgcaagga ccagctccag tcctatatct gcttctgcct ccctgccttc      360

gagggccgga actgtgagac gcacaaggat gaccagctga tctgtgtgaa cgagaacggc      420

ggctgtgagc agtactgcag tgaccacacg ggcaccaagc gctcctgtcg gtgccacgag      480

gggtactctc tgctggcaga cggggtgtcc tgcacaccca cagttgaata tccatgtgga      540

aaaataccta ttctagaaaa aagaaatgcc agcaagcccc aagggcgagg atccgacaca      600

cctcccccgt gcccaaggtg cccagcacct gaactcctgg gaggaccgtc agtcttcctc      660

ttccccccaa aacccaagga tacccttatg atttcccgga cccctgaggt cacgtgcgtg      720

gtggtggacg tgagccacga agaccccgag gtccagttca agtggtacgt ggacggcgtg      780

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gttccgtgtg      840

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      900

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaaac caaaggacag      960

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1020

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag     1080

agcagcgggc agccggagaa caactacaac accacgcctc ccatgctgga ctccgacggc     1140

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacatc     1200

ttctcatgct ccgtgatgca tgaggctctg cacaaccgct tcacacagaa gagcctctcc     1260

ctgtctccgg gtaaatgagc ggccgc                                          1286


<210>  6
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Ser 
            180                 185                 190         


Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly 
        195                 200                 205             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    210                 215                 220                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
225                 230                 235                 240 


Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val 
                245                 250                 255     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe 
            260                 265                 270         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        275                 280                 285             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    290                 295                 300                 


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
305                 310                 315                 320 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                325                 330                 335     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            340                 345                 350         


Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro 
        355                 360                 365             


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    370                 375                 380                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met 
385                 390                 395                 400 


His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Lys 
            


<210>  7
<211>  2051
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
aagctttgca gagatttcat catggtctcc caggccctca ggctcctctg ccttctgctt       60

gggcttcagg gctgcctggc tgcagtcttc gtaacccagg aggaagccca cggcgtcctg      120

caccggcgcc ggcgcgccaa cgcgttcctg gaggagctgc ggccgggctc cctggagagg      180

gagtgcaagg aggagcagtg ctccttcgag gaggcccggg agatcttcaa ggacgcggag      240

aggacgaagc tgttctggat ttcttacagt gatggtgacc agtgtgcctc aagtccatgc      300

cagaatgggg gctcctgcaa ggaccagctc cagtcctata tctgcttctg cctccctgcc      360

ttcgagggcc ggaactgtga gacgcacaag gatgaccagc tgatctgtgt gaacgagaac      420

ggcggctgtg agcagtactg cagtgaccac acgggcacca agcgctcctg tcggtgccac      480

gaggggtact ctctgctggc agacggggtg tcctgcacac ccacagttga atatccatgt      540

ggaaaaatac ctattctaga aaaaagaaat gccagcaagc cccaagggcg aattgtgggg      600

ggcaaggtgt gccccaaagg ggagtgtcca tggcaggtcc tgttgttggt gaatggagct      660

cagttgtgtg gggggaccct gatcaacacc atctgggtgg tctccgcggc ccactgtttc      720

gacaaaatca agaactggag gaacctgatc gcggtgctcg gggagcacga cctcagcgag      780

cacgacgggg atgagcagag ccggcgggtg gcgcaggtca tcatccccag cacgtacgtc      840

ccgggcacca ccaaccacga catcgcgctg ctccgcctgc accagcccgt ggtcctcact      900

gaccatgtgg tgcccctctg cctgcccgaa cggacgttct ctgagaggac gctggccttc      960

gtgcgcttct cattggtcag cggctggggc cagctgctgg accgtggcgc cacggccctg     1020

gagctcatgg tcctcaacgt gccccggctg atgacccagg actgcctgca gcagtcacgg     1080

aaggtgggag actccccaaa tatcacggag tacatgttct gtgccggcta ctcggatggc     1140

agcaaggact cctgcgcggg ggacagtgga ggcccacatg ccacccacta ccggggcacg     1200

tggtacctga cgggcatcgt cagctggggc cagggctgcg caaccgtggg ccactttggg     1260

gtgtacacca gggtctccca gtacatcgag tggctgcaaa agctcatgcg ctcagagcca     1320

cgcccaggag tcctcctgcg agccccattt cccggatccg acacacctcc cccgtgccca     1380

aggtgcccag cacctgaact cctgggagga ccgtcagtct tcctcttccc cccaaaaccc     1440

aaggataccc ttatgatttc ccggacccct gaggtcacgt gcgtggtggt ggacgtgagc     1500

cacgaagacc ccgaggtcca gttcaagtgg tacgtggacg gcgtggaggt gcataatgcc     1560

aagacaaagc cgcgggagga gcagtacaac agcacgttcc gtgtggtcag cgtcctcacc     1620

gtcctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtctc caacaaagcc     1680

ctcccagccc ccatcgagaa aaccatctcc aaaaccaaag gacagccccg agaaccacag     1740

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1800

ctggtcaaag gcttctaccc cagcgacatc gccgtggagt gggagagcag cgggcagccg     1860

gagaacaact acaacaccac gcctcccatg ctggactccg acggctcctt cttcctctac     1920

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acatcttctc atgctccgtg     1980

atgcatgagg ctctgcacaa ccgcttcaca cagaagagcc tctccctgtc tccgggtaaa     2040

tgagcggccg c                                                          2051


<210>  8
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Ser Asp Thr 
        435                 440                 445             


Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    450                 455                 460                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
465                 470                 475                 480 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                485                 490                 495     


Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn 
            500                 505                 510         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val 
        515                 520                 525             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    530                 535                 540                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
545                 550                 555                 560 


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                565                 570                 575     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            580                 585                 590         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        595                 600                 605             


Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu 
    610                 615                 620                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
625                 630                 635                 640 


Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu 
                645                 650                 655     


Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            660                 665                 670         


Lys 
    


<210>  9
<211>  2054
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
aagctttgca gagatttcat catggtctcc caggccctca ggctcctctg ccttctgctt       60

gggcttcagg gctgcctggc tgcagtcttc gtaacccagg aggaagccca cggcgtcctg      120

caccggcgcc ggcgcgccaa cgcgttcctg gaggagctgc ggccgggctc cctggagagg      180

gagtgcaagg aggagcagtg ctccttcgag gaggcccggg agatcttcaa ggacgcggag      240

aggacgaagc tgttctggat ttcttacagt gatggtgacc agtgtgcctc aagtccatgc      300

cagaatgggg gctcctgcaa ggaccagctc cagtcctata tctgcttctg cctccctgcc      360

ttcgagggcc ggaactgtga gacgcacaag gatgaccagc tgatctgtgt gaacgagaac      420

ggcggctgtg agcagtactg cagtgaccac acgggcacca agcgctcctg tcggtgccac      480

gaggggtact ctctgctggc agacggggtg tcctgcacac ccacagttga atatccatgt      540

ggaaaaatac ctattctaga aaaaagaaat gccagcaagc cccaagggcg aattgtgggg      600

ggcaaggtgt gccccaaagg ggagtgtcca tggcaggtcc tgttgttggt gaatggagct      660

cagttgtgtg gggggaccct gatcaacacc atctgggtgg tctccgcggc ccactgtttc      720

gacaaaatca agaactggag gaacctgatc gcggtgctcg gggagcacga cctcagcgag      780

cacgacgggg atgagcagag ccggcgggtg gcgcaggtca tcatccccag cacgtacgtc      840

ccgggcacca ccaaccacga catcgcgctg ctccgcctgc accagcccgt ggtcctcact      900

gaccatgtgg tgcccctctg cctgcccgaa cggacgttct ctgagaggac gctggccttc      960

gtgcgcttct cattggtcag cggctggggc cagctgctgg accgtggcgc cacggccctg     1020

gagctcatgg tcctcaacgt gccccggctg atgacccagg actgcctgca gcagtcacgg     1080

aaggtgggag actccccaaa tatcacggag tacatgttct gtgccggcta ctcggatggc     1140

agcaaggact cctgcgcggg ggacagtgga ggcccacatg ccacccacta ccggggcacg     1200

tggtacctga cgggcatcgt cagctggggc cagggctgcg caaccgtggg ccactttggg     1260

gtgtacacca gggtctccca gtacatcgag tggctgcaaa agctcatgcg ctcagagcca     1320

cgcccaggag tcctcctgcg agccccattt cccggatccg acaaaactca cacatgccca     1380

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     1440

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1500

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1560

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1620

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1680

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1740

gtgtacgccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1800

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1860

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1920

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1980

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     2040

tgataagcgg ccgc                                                       2054


<210>  10
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Ser Asp Lys 
        435                 440                 445             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    450                 455                 460                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
465                 470                 475                 480 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                485                 490                 495     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            500                 505                 510         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        515                 520                 525             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    530                 535                 540                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
545                 550                 555                 560 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Ala 
                565                 570                 575     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            580                 585                 590         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        595                 600                 605             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    610                 615                 620                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
625                 630                 635                 640 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                645                 650                 655     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            660                 665                 670         


Lys 
    


<210>  11
<211>  2054
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
aagctttgca gagatttcat catggtctcc caggccctca ggctcctctg ccttctgctt       60

gggcttcagg gctgcctggc tgcagtcttc gtaacccagg aggaagccca cggcgtcctg      120

caccggcgcc ggcgcgccaa cgcgttcctg gaggagctgc ggccgggctc cctggagagg      180

gagtgcaagg aggagcagtg ctccttcgag gaggcccggg agatcttcaa ggacgcggag      240

aggacgaagc tgttctggat ttcttacagt gatggtgacc agtgtgcctc aagtccatgc      300

cagaatgggg gctcctgcaa ggaccagctc cagtcctata tctgcttctg cctccctgcc      360

ttcgagggcc ggaactgtga gacgcacaag gatgaccagc tgatctgtgt gaacgagaac      420

ggcggctgtg agcagtactg cagtgaccac acgggcacca agcgctcctg tcggtgccac      480

gaggggtact ctctgctggc agacggggtg tcctgcacac ccacagttga atatccatgt      540

ggaaaaatac ctattctaga aaaaagaaat gccagcaagc cccaagggcg aattgtgggg      600

ggcaaggtgt gccccaaagg ggagtgtcca tggcaggtcc tgttgttggt gaatggagct      660

cagttgtgtg gggggaccct gatcaacacc atctgggtgg tctccgcggc ccactgtttc      720

gacaaaatca agaactggag gaacctgatc gcggtgctcg gggagcacga cctcagcgag      780

cacgacgggg atgagcagag ccggcgggtg gcgcaggtca tcatccccag cacgtacgtc      840

ccgggcacca ccaaccacga catcgcgctg ctccgcctgc accagcccgt ggtcctcact      900

gaccatgtgg tgcccctctg cctgcccgaa cggacgttct ctgagaggac gctggccttc      960

gtgcgcttct cattggtcag cggctggggc cagctgctgg accgtggcgc cacggccctg     1020

gagctcatgg tcctcaacgt gccccggctg atgacccagg actgcctgca gcagtcacgg     1080

aaggtgggag actccccaaa tatcacggag tacatgttct gtgccggcta ctcggatggc     1140

agcaaggact cctgcgcggg ggacagtgga ggcccacatg ccacccacta ccggggcacg     1200

tggtacctga cgggcatcgt cagctggggc cagggctgcg caaccgtggg ccactttggg     1260

gtgtacacca gggtctccca gtacatcgag tggctgcaaa agctcatgcg ctcagagcca     1320

cgcccaggag tcctcctgcg agccccattt cccggatccg acaaaactca cacatgccca     1380

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     1440

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1500

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1560

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1620

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1680

ctcccagccc ccatcgcgaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1740

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1800

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1860

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1920

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1980

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     2040

tgataagcgg ccgc                                                       2054


<210>  12
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Ile Val 
            180                 185                 190         


Gly Gly Lys Val Cys Pro Lys Gly Glu Cys Pro Trp Gln Val Leu Leu 
        195                 200                 205             


Leu Val Asn Gly Ala Gln Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile 
    210                 215                 220                 


Trp Val Val Ser Ala Ala His Cys Phe Asp Lys Ile Lys Asn Trp Arg 
225                 230                 235                 240 


Asn Leu Ile Ala Val Leu Gly Glu His Asp Leu Ser Glu His Asp Gly 
                245                 250                 255     


Asp Glu Gln Ser Arg Arg Val Ala Gln Val Ile Ile Pro Ser Thr Tyr 
            260                 265                 270         


Val Pro Gly Thr Thr Asn His Asp Ile Ala Leu Leu Arg Leu His Gln 
        275                 280                 285             


Pro Val Val Leu Thr Asp His Val Val Pro Leu Cys Leu Pro Glu Arg 
    290                 295                 300                 


Thr Phe Ser Glu Arg Thr Leu Ala Phe Val Arg Phe Ser Leu Val Ser 
305                 310                 315                 320 


Gly Trp Gly Gln Leu Leu Asp Arg Gly Ala Thr Ala Leu Glu Leu Met 
                325                 330                 335     


Val Leu Asn Val Pro Arg Leu Met Thr Gln Asp Cys Leu Gln Gln Ser 
            340                 345                 350         


Arg Lys Val Gly Asp Ser Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala 
        355                 360                 365             


Gly Tyr Ser Asp Gly Ser Lys Asp Ser Cys Ala Gly Asp Ser Gly Gly 
    370                 375                 380                 


Pro His Ala Thr His Tyr Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val 
385                 390                 395                 400 


Ser Trp Gly Gln Gly Cys Ala Thr Val Gly His Phe Gly Val Tyr Thr 
                405                 410                 415     


Arg Val Ser Gln Tyr Ile Glu Trp Leu Gln Lys Leu Met Arg Ser Glu 
            420                 425                 430         


Pro Arg Pro Gly Val Leu Leu Arg Ala Pro Phe Pro Gly Ser Asp Lys 
        435                 440                 445             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    450                 455                 460                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
465                 470                 475                 480 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                485                 490                 495     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            500                 505                 510         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        515                 520                 525             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    530                 535                 540                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Ala Lys 
545                 550                 555                 560 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                565                 570                 575     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            580                 585                 590         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        595                 600                 605             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    610                 615                 620                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
625                 630                 635                 640 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                645                 650                 655     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            660                 665                 670         


Lys 
    


<210>  13
<211>  1307
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
aagcttgaat tcgccaccat ggtctcccag gccctcaggc tcctctgcct tctgcttggg       60

cttcagggct gcctggctgc agtcttcgta acccaggagg aagcccacgg cgtcctgcac      120

cggcgccggc gcgccaacgc gttcctggag gagctgcggc cgggctccct ggagagggag      180

tgcaaggagg agcagtgctc cttcgaggag gcccgggaga tcttcaagga cgcggagagg      240

acgaagctgt tctggatttc ttacagtgat ggtgaccagt gtgcctcaag tccatgccag      300

aatgggggct cctgcaagga ccagctccag tcctatatct gcttctgcct ccctgccttc      360

gagggccgga actgtgagac gcacaaggat gaccagctga tctgtgtgaa cgagaacggc      420

ggctgtgagc agtactgcag tgaccacacg ggcaccaagc gctcctgtcg gtgccacgag      480

gggtactctc tgctggcaga cggggtgtcc tgcacaccca cagttgaata tccatgtgga      540

aaaataccta ttctagaaaa aagaaatgcc agcaagcccc aagggcgagg atccgcagag      600

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      660

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      720

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      780

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      840

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      900

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc      960

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1020

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1080

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1140

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1200

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1260

acgcagaaga gcctctccct gtctccgggt aaatgataag cggccgc                   1307


<210>  14
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Ser 
            180                 185                 190         


Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        195                 200                 205             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    210                 215                 220                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
225                 230                 235                 240 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                245                 250                 255     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            260                 265                 270         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        275                 280                 285             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    290                 295                 300                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425 


<210>  15
<211>  1289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
aagcttgaat tcgccaccat ggtctcccag gccctcaggc tcctctgcct tctgcttggg       60

cttcagggct gcctggctgc agtcttcgta acccaggagg aagcccacgg cgtcctgcac      120

cggcgccggc gcgccaacgc gttcctggag gagctgcggc cgggctccct ggagagggag      180

tgcaaggagg agcagtgctc cttcgaggag gcccgggaga tcttcaagga cgcggagagg      240

acgaagctgt tctggatttc ttacagtgat ggtgaccagt gtgcctcaag tccatgccag      300

aatgggggct cctgcaagga ccagctccag tcctatatct gcttctgcct ccctgccttc      360

gagggccgga actgtgagac gcacaaggat gaccagctga tctgtgtgaa cgagaacggc      420

ggctgtgagc agtactgcag tgaccacacg ggcaccaagc gctcctgtcg gtgccacgag      480

gggtactctc tgctggcaga cggggtgtcc tgcacaccca cagttgaata tccatgtgga      540

aaaataccta ttctagaaaa aagaaatgcc agcaagcccc aagggcgagg atccgacaaa      600

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      660

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      720

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      780

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      840

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      900

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag      960

ccccgagaac cacaggtgta cgccctgccc ccatcccggg atgagctgac caagaaccag     1020

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1080

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1140

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1200

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1260

ctgtctccgg gtaaatgata agcggccgc                                       1289


<210>  16
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Asp Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile 
                165                 170                 175     


Pro Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Ser 
            180                 185                 190         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        195                 200                 205             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    210                 215                 220                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
225                 230                 235                 240 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                245                 250                 255     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            260                 265                 270         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        275                 280                 285             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    290                 295                 300                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
305                 310                 315                 320 


Tyr Ala Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                325                 330                 335     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            340                 345                 350         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        355                 360                 365             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    370                 375                 380                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
385                 390                 395                 400 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Lys 
            


<210>  17
<211>  1289
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
aagcttggat tcgccaccat ggtctcccag gccctcaggc tcctctgcct tctgcttggg       60

cttcagggct gcctggctgc agtcttcgta acccaggagg aagcccacgg cgtcctgcac      120

cggcgccggc gcgccaacgc gttcctggag gagctgcggc cgggctccct ggagagggag      180

tgcaaggagg agcagtgctc cttcgaggag gcccgggaga tcttcaagga cgcggagagg      240

acgaagctgt tctggatttc ttacagtgat ggtgaccagt gtgcctcaag tccatgccag      300

aatgggggct cctgcaagga ccagctccag tcctatatct gcttctgcct ccctgccttc      360

gagggccgga actgtgagac gcacaaggat gaccagctga tctgtgtgaa cgagaacggc      420

ggctgtgagc agtactgcag tgaccacacg ggcaccaagc gctcctgtcg gtgccacgag      480

gggtactctc tgctggcaga cggggtgtcc tgcacaccca cagttgaata tccatgtgga      540

aaaataccta ttctagaaaa aagaaatgcc agcaagcccc aagggcgagg atccgacaaa      600

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      660

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      720

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      780

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      840

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      900

gtctccaaca aagccctccc agcccccatc gcgaaaacca tctccaaagc caaagggcag      960

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1020

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1080

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1140

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1200

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1260

ctgtctccgg gtaaatgata agcggccgc                                       1289


<210>  18
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Val Ser Gln Ala Leu Arg Leu Leu Cys Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Gly Cys Leu Ala Ala Val Phe Val Thr Gln Glu Glu Ala His Gly Val 
            20                  25                  30          


Leu His Arg Arg Arg Arg Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro 
        35                  40                  45              


Gly Ser Leu Glu Arg Glu Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu 
    50                  55                  60                  


Ala Arg Glu Ile Phe Lys Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile 
65                  70                  75                  80  


Ser Tyr Ser Asp Gly Asp Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly 
                85                  90                  95      


Gly Ser Cys Lys Asp Gln Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro 
            100                 105                 110         


Ala Phe Glu Gly Arg Asn Cys Glu Thr His Lys Asp Asp Gln Leu Ile 
        115                 120                 125             


Cys Val Asn Glu Asn Gly Gly Cys Glu Gln Tyr Cys Ser Asp His Thr 
    130                 135                 140                 


Gly Thr Lys Arg Ser Cys Arg Cys His Glu Gly Tyr Ser Leu Leu Ala 
145                 150                 155                 160 


Gly Val Ser Cys Thr Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro 
                165                 170                 175     


Ile Leu Glu Lys Arg Asn Ala Ser Lys Pro Gln Gly Arg Gly Ser Asp 
            180                 185                 190         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        195                 200                 205             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    210                 215                 220                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
225                 230                 235                 240 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                245                 250                 255     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            260                 265                 270         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        275                 280                 285             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Ala 
    290                 295                 300                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
305                 310                 315                 320 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                325                 330                 335     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            340                 345                 350         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        355                 360                 365             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    370                 375                 380                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
385                 390                 395                 400 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                405                 410                 415     


Gly Lys 
        


