               SEQUENCE LISTING

<110> Schomburg Lutz

<120> Biomarker For Endocrine Autoimmune-Related Dysfunction

<130> DG018122-P-WO

<150> DE102017204268.0
<151> 2017-03-14

<160> 16

<170> BiSSAP 1.3.2

<210> 1
<211> 539
<212> PRT
<213> Homo sapiens


<400> 1
Met Ala Leu Gln Ser Gln Ala Ser Glu Glu Ala Lys Gly Pro Trp Gln 
1               5                   10                  15      
Glu Ala Asp Gln Glu Gln Gln Glu Pro Val Gly Ser Pro Glu Pro Glu 
            20                  25                  30          
Ser Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Pro Val Pro Pro 
        35                  40                  45              
Pro Glu Pro Gln Pro Glu Pro Gln Pro Leu Pro Asp Pro Ala Pro Leu 
    50                  55                  60                  
Pro Glu Leu Glu Phe Glu Ser Glu Arg Val His Glu Pro Glu Pro Thr 
65                  70                  75                  80  
Pro Thr Val Glu Thr Arg Gly Thr Ala Arg Gly Phe Gln Pro Pro Glu 
                85                  90                  95      
Gly Gly Phe Gly Trp Val Val Val Phe Ala Ala Thr Trp Cys Asn Gly 
            100                 105                 110         
Ser Ile Phe Gly Ile His Asn Ser Val Gly Ile Leu Tyr Ser Met Leu 
        115                 120                 125             
Leu Glu Glu Glu Lys Glu Lys Asn Arg Gln Val Glu Phe Gln Ala Ala 
    130                 135                 140                 
Trp Val Gly Ala Leu Ala Met Gly Met Ile Phe Phe Cys Ser Pro Ile 
145                 150                 155                 160 
Val Ser Ile Phe Thr Asp Arg Leu Gly Cys Arg Ile Thr Ala Thr Ala 
                165                 170                 175     
Gly Ala Ala Val Ala Phe Ile Gly Leu His Thr Ser Ser Phe Thr Ser 
            180                 185                 190         
Ser Leu Ser Leu Arg Tyr Phe Thr Tyr Gly Ile Leu Phe Gly Cys Gly 
        195                 200                 205             
Cys Ser Phe Ala Phe Gln Pro Ser Leu Val Ile Leu Gly His Tyr Phe 
    210                 215                 220                 
Gln Arg Arg Leu Gly Leu Ala Asn Gly Val Val Ser Ala Gly Ser Ser 
225                 230                 235                 240 
Ile Phe Ser Met Ser Phe Pro Phe Leu Ile Arg Met Leu Gly Asp Lys 
                245                 250                 255     
Ile Lys Leu Ala Gln Thr Phe Gln Val Leu Ser Thr Phe Met Phe Val 
            260                 265                 270         
Leu Met Leu Leu Ser Leu Thr Tyr Arg Pro Leu Leu Pro Ser Ser Gln 
        275                 280                 285             
Asp Thr Pro Ser Lys Arg Gly Val Arg Thr Leu His Gln Arg Phe Leu 
    290                 295                 300                 
Ala Gln Leu Arg Lys Tyr Phe Asn Met Arg Val Phe Arg Gln Arg Thr 
305                 310                 315                 320 
Tyr Arg Ile Trp Ala Phe Gly Ile Ala Ala Ala Ala Leu Gly Tyr Phe 
                325                 330                 335     
Val Pro Tyr Val His Leu Met Lys Tyr Val Glu Glu Glu Phe Ser Glu 
            340                 345                 350         
Ile Lys Glu Thr Trp Val Leu Leu Val Cys Ile Gly Ala Thr Ser Gly 
        355                 360                 365             
Leu Gly Arg Leu Val Ser Gly His Ile Ser Asp Ser Ile Pro Gly Leu 
    370                 375                 380                 
Lys Lys Ile Tyr Leu Gln Val Leu Ser Phe Leu Leu Leu Gly Leu Met 
385                 390                 395                 400 
Ser Met Met Ile Pro Leu Cys Arg Asp Phe Gly Gly Leu Ile Val Val 
                405                 410                 415     
Cys Leu Phe Leu Gly Leu Cys Asp Gly Phe Phe Ile Thr Ile Met Ala 
            420                 425                 430         
Pro Ile Ala Phe Glu Leu Val Gly Pro Met Gln Ala Ser Gln Ala Ile 
        435                 440                 445             
Gly Tyr Leu Leu Gly Met Met Ala Leu Pro Met Ile Ala Gly Pro Pro 
    450                 455                 460                 
Ile Ala Gly Leu Leu Arg Asn Cys Phe Gly Asp Tyr His Val Ala Phe 
465                 470                 475                 480 
Tyr Phe Ala Gly Val Pro Pro Ile Ile Gly Ala Val Ile Leu Phe Phe 
                485                 490                 495     
Val Pro Leu Met His Gln Arg Met Phe Lys Lys Glu Gln Arg Asp Ser 
            500                 505                 510         
Ser Lys Asp Lys Met Leu Ala Pro Asp Pro Asp Pro Asn Gly Glu Leu 
        515                 520                 525             
Leu Pro Gly Ser Pro Asn Pro Glu Glu Pro Ile 
    530                 535                 

<210> 2
<211> 515
<212> PRT
<213> Homo sapiens


<400> 2
Met Val Leu Ser Gln Glu Glu Pro Asp Ser Ala Arg Gly Thr Ser Glu 
1               5                   10                  15      
Ala Gln Pro Leu Gly Pro Ala Pro Thr Gly Ala Ala Pro Pro Pro Gly 
            20                  25                  30          
Pro Gly Pro Ser Asp Ser Pro Glu Ala Ala Val Glu Lys Val Glu Val 
        35                  40                  45              
Glu Leu Ala Gly Pro Ala Thr Ala Glu Pro His Glu Pro Pro Glu Pro 
    50                  55                  60                  
Pro Glu Gly Gly Trp Gly Trp Leu Val Met Leu Ala Ala Met Trp Cys 
65                  70                  75                  80  
Asn Gly Ser Val Phe Gly Ile Gln Asn Ala Cys Gly Val Leu Phe Val 
                85                  90                  95      
Ser Met Leu Glu Thr Phe Gly Ser Lys Asp Asp Asp Lys Met Val Phe 
            100                 105                 110         
Lys Thr Ala Trp Val Gly Ser Leu Ser Met Gly Met Ile Phe Phe Cys 
        115                 120                 125             
Cys Pro Ile Val Ser Val Phe Thr Asp Leu Phe Gly Cys Arg Lys Thr 
    130                 135                 140                 
Ala Val Val Gly Ala Ala Val Gly Phe Val Gly Leu Met Ser Ser Ser 
145                 150                 155                 160 
Phe Val Ser Ser Ile Glu Pro Leu Tyr Leu Thr Tyr Gly Ile Ile Phe 
                165                 170                 175     
Ala Cys Gly Cys Ser Phe Ala Tyr Gln Pro Ser Leu Val Ile Leu Gly 
            180                 185                 190         
His Tyr Phe Lys Lys Arg Leu Gly Leu Val Asn Gly Ile Val Thr Ala 
        195                 200                 205             
Gly Ser Ser Val Phe Thr Ile Leu Leu Pro Leu Leu Leu Arg Val Leu 
    210                 215                 220                 
Ile Asp Ser Val Gly Leu Phe Tyr Thr Leu Arg Val Leu Cys Ile Phe 
225                 230                 235                 240 
Met Phe Val Leu Phe Leu Ala Gly Phe Thr Tyr Arg Pro Leu Ala Thr 
                245                 250                 255     
Ser Thr Lys Asp Lys Glu Ser Gly Gly Ser Gly Ser Ser Leu Phe Ser 
            260                 265                 270         
Arg Lys Lys Phe Ser Pro Pro Lys Lys Ile Phe Asn Phe Ala Ile Phe 
        275                 280                 285             
Lys Val Thr Ala Tyr Ala Val Trp Ala Val Gly Ile Pro Leu Ala Leu 
    290                 295                 300                 
Phe Gly Tyr Phe Val Pro Tyr Val His Leu Met Lys His Val Asn Glu 
305                 310                 315                 320 
Arg Phe Gln Asp Glu Lys Asn Lys Glu Val Val Leu Met Cys Ile Gly 
                325                 330                 335     
Val Thr Ser Gly Val Gly Arg Leu Leu Phe Gly Arg Ile Ala Asp Tyr 
            340                 345                 350         
Val Pro Gly Val Lys Lys Val Tyr Leu Gln Val Leu Ser Phe Phe Phe 
        355                 360                 365             
Ile Gly Leu Met Ser Met Met Ile Pro Leu Cys Ser Ile Phe Gly Ala 
    370                 375                 380                 
Leu Ile Ala Val Cys Leu Ile Met Gly Leu Phe Asp Gly Cys Phe Ile 
385                 390                 395                 400 
Ser Ile Met Ala Pro Ile Ala Phe Glu Leu Val Gly Ala Gln Asp Val 
                405                 410                 415     
Ser Gln Ala Ile Gly Phe Leu Leu Gly Phe Met Ser Ile Pro Met Thr 
            420                 425                 430         
Val Gly Pro Pro Ile Ala Gly Leu Leu Arg Asp Lys Leu Gly Ser Tyr 
        435                 440                 445             
Asp Val Ala Phe Tyr Leu Ala Gly Val Pro Pro Leu Ile Gly Gly Ala 
    450                 455                 460                 
Val Leu Cys Phe Ile Pro Trp Ile His Ser Lys Lys Gln Arg Glu Ile 
465                 470                 475                 480 
Ser Lys Thr Thr Gly Lys Glu Lys Met Glu Lys Met Leu Glu Asn Gln 
                485                 490                 495     
Asn Ser Leu Leu Ser Ser Ser Ser Gly Met Phe Lys Lys Glu Ser Asp 
            500                 505                 510         
Ser Ile Ile 
        515 

<210> 3
<211> 27
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 3
attgaattcg tcaccgacgc caaaaac                                        27


<210> 4
<211> 27
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 4
attggatcct tacacggcga tctttcc                                        27


<210> 5
<211> 1656
<212> DNA
<213> Photinus pyralis

<223> "GenBank U47123.2"

<220> 
<223> GenBank U47123.2

<400> 5
atggtcaccg acgccaaaaa cataaagaaa ggcccggcgc cattctatcc gctggaagat      60

ggaaccgctg gagagcaact gcataaggct atgaagagat acgccctggt tcctggaaca     120

attgctttta cagatgcaca tatcgaggtg gacatcactt acgctgagta cttcgaaatg     180

tccgttcggt tggcagaagc tatgaaacga tatgggctga atacaaatca cagaatcgtc     240

gtatgcagtg aaaactctct tcaattcttt atgccggtgt tgggcgcgtt atttatcgga     300

gttgcagttg cgcccgcgaa cgacatttat aatgaacgtg aattgctcaa cagtatgggc     360

atttcgcagc ctaccgtggt gttcgtttcc aaaaaggggt tgcaaaaaat tttgaacgtg     420

caaaaaaagc tcccaatcat ccaaaaaatt attatcatgg attctaaaac ggattaccag     480

ggatttcagt cgatgtacac gttcgtcaca tctcatctac ctcccggttt taatgaatac     540

gattttgtgc cagagtcctt cgatagggac aagacaattg cactgatcat gaactcctct     600

ggatctactg gtctgcctaa aggtgtcgct ctgcctcata gaactgcctg cgtgagattc     660

tcgcatgcca gagatcctat ttttggcaat caaatcattc cggatactgc gattttaagt     720

gttgttccat tccatcacgg ttttggaatg tttactacac tcggatattt gatatgtgga     780

tttcgagtcg tcttaatgta tagatttgaa gaagagctgt ttctgaggag ccttcaggat     840

tacaagattc aaagtgcgct gctggtgcca accctattct ccttcttcgc caaaagcact     900

ctgattgaca aatacgattt atctaattta cacgaaattg cttctggtgg cgctcccctc     960

tctaaggaag tcggggaagc ggttgccaag aggttccatc tgccaggtat caggcaagga    1020

tatgggctca ctgagactac atcagctatt ctgattacac ccgaggggga tgataaaccg    1080

ggcgcggtcg gtaaagttgt tccatttttt gaagcgaagg ttgtggatct ggataccggg    1140

aaaacgctgg gcgttaatca aagaggcgaa ctgtgtgtga gaggtcctat gattatgtcc    1200

ggttatgtaa acaatccgga agcgaccaac gccttgattg acaaggatgg atggctacat    1260

tctggagaca tagcttactg ggacgaagac gaacacttct tcatcgttga ccgcctgaag    1320

tctctgatta agtacaaagg ctatcaggtg gctcccgctg aattggaatc catcttgctc    1380

caacacccca acatcttcga cgcaggtgtc gcaggtcttc ccgacgatga cgccggtgaa    1440

cttcccgccg ccgttgttgt tttggagcac ggaaagacga tgacggaaaa agagatcgtg    1500

gattacgtcg ccagtcaagt aacaaccgcg aaaaagttgc gcggaggagt tgtgtttgtg    1560

gacgaagtac cgaaaggtct taccggaaaa ctcgacgcaa gaaaaatcag agagatcctc    1620

ataaaggcca agaagggcgg aaagatcgcc gtgtaa                              1656


<210> 6
<211> 550
<212> PRT
<213> Photinus pyralis


<400> 6
Val Thr Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      
Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          
Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              
Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  
Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  
Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      
Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         
Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             
Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 
Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 
Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     
Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         
Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             
Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 
Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 
Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     
Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         
Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             
Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 
Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 
Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     
Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         
Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             
Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 
Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 
Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     
Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         
Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             
Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 
Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 
Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     
Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         
Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             
Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 
Gly Gly Lys Ile Ala Val 
545                 550 

<210> 7
<211> 1620
<212> DNA
<213> Homo sapiens

<223> "CDS 146...1765 of NCBI NM_006517.4"

<220> 
<223> CDS 146...1765 of NCBI NM_006517.4

<400> 7
atggcgctgc aaagccaggc gagcgaggaa gcaaaggggc cctggcagga ggcagaccag      60

gaacagcagg agccggtggg tagcccagag ccggagtctg agccggagcc tgagcccgag     120

cccgagcccg tgccagtgcc cccgcccgag ccccagccgg agccccagcc cctaccggac     180

cccgcacccc tgccggagct ggagttcgag tccgagcggg tgcacgaacc cgagcccacg     240

cctacggtag agacccgcgg caccgcgcgc ggcttccagc ctcccgaagg tggcttcggc     300

tgggtggtgg tgttcgctgc cacctggtgc aacggctcca tcttcggcat ccataactct     360

gtcgggatcc tctactccat gctgctagag gaggaaaagg aaaaaaatcg ccaagtggag     420

ttccaagcag catgggtcgg agccctcgcg atgggtatga tcttcttctg ttctcccatt     480

gtgagtatat tcactgaccg tttgggctgc cgaatcacag caaccgcggg ggctgccgtt     540

gctttcattg gcctccatac cagctccttc accagctccc taagcctgcg ctacttcacc     600

tacgggattc tctttggttg tggctgttcc ttcgcctttc agccatccct cgtcatcctg     660

ggccactact ttcaacgccg cctgggtctg gccaatggtg tggtgtctgc tgggagtagc     720

attttctcca tgtccttccc cttcctcatc agaatgctgg gggataagat caagctggcc     780

caaaccttcc aggtgctgag taccttcatg tttgttctta tgctgctttc actcacctac     840

cggcccctcc tgcccagctc ccaggacacc ccaagcaaga gaggtgtccg caccctgcac     900

cagcgctttc tggctcagct caggaagtac ttcaacatgc gagtgttccg ccaacgcact     960

taccgcatct gggccttcgg aattgctgct gctgcccttg gctactttgt tccctatgta    1020

cacctgatga agtatgtgga ggaggagttc tcagaaatca aggagacctg ggtgctcttg    1080

gtgtgtattg gggctacctc aggccttggg cgtcttgtgt caggccacat cagtgactcc    1140

atccctggac ttaagaagat ctacttgcag gtcctttcct tcctgctcct gggcctgatg    1200

tccatgatga ttcccctgtg ccgggacttc gggggcctta tcgtcgtctg tcttttcctg    1260

ggcctttgcg atggcttctt catcaccatc atggccccca ttgcatttga gctggtgggc    1320

ccaatgcagg cctcacaggc cattggctac ctcctgggca tgatggccct gccaatgatt    1380

gctgggcccc ccattgcagg cctactccgc aactgttttg gggactacca tgtggccttc    1440

tactttgccg gtgtgccccc catcatcggg gctgtaatcc tcttcttcgt ccctctgatg    1500

catcaaagga tgttcaagaa agagcagaga gattccagca aggataagat gttggcccct    1560

gacccagacc ccaatgggga gctactgccg ggctccccca accctgagga accaatctaa    1620


<210> 8
<211> 32
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 8
attgcggccg caccatggcg ctgcaaagcc ag                                   32


<210> 9
<211> 33
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 9
gcgcgaattc gattggttcc tcagggttgg ggg                                  33


<210> 10
<211> 3276
<212> DNA
<213> Artificial Sequence

<223> "Coding Seq Fusionprotein"

<220> 
<223> Coding Seq Fusionprotein

<400> 10
atggcgctgc aaagccaggc gagcgaggaa gcaaaggggc cctggcagga ggcagaccag       60

gaacagcagg agccggtggg tagcccagag ccggagtctg agccggagcc tgagcccgag      120

cccgagcccg tgccagtgcc cccgcccgag ccccagccgg agccccagcc cctaccggac      180

cccgcacccc tgccggagct ggagttcgag tccgagcggg tgcacgaacc cgagcccacg      240

cctacggtag agacccgcgg caccgcgcgc ggcttccagc ctcccgaagg tggcttcggc      300

tgggtggtgg tgttcgctgc cacctggtgc aacggctcca tcttcggcat ccataactct      360

gtcgggatcc tctactccat gctgctagag gaggaaaagg aaaaaaatcg ccaagtggag      420

ttccaagcag catgggtcgg agccctcgcg atgggtatga tcttcttctg ttctcccatt      480

gtgagtatat tcactgaccg tttgggctgc cgaatcacag caaccgcggg ggctgccgtt      540

gctttcattg gcctccatac cagctccttc accagctccc taagcctgcg ctacttcacc      600

tacgggattc tctttggttg tggctgttcc ttcgcctttc agccatccct cgtcatcctg      660

ggccactact ttcaacgccg cctgggtctg gccaatggtg tggtgtctgc tgggagtagc      720

attttctcca tgtccttccc cttcctcatc agaatgctgg gggataagat caagctggcc      780

caaaccttcc aggtgctgag taccttcatg tttgttctta tgctgctttc actcacctac      840

cggcccctcc tgcccagctc ccaggacacc ccaagcaaga gaggtgtccg caccctgcac      900

cagcgctttc tggctcagct caggaagtac ttcaacatgc gagtgttccg ccaacgcact      960

taccgcatct gggccttcgg aattgctgct gctgcccttg gctactttgt tccctatgta     1020

cacctgatga agtatgtgga ggaggagttc tcagaaatca aggagacctg ggtgctcttg     1080

gtgtgtattg gggctacctc aggccttggg cgtcttgtgt caggccacat cagtgactcc     1140

atccctggac ttaagaagat ctacttgcag gtcctttcct tcctgctcct gggcctgatg     1200

tccatgatga ttcccctgtg ccgggacttc gggggcctta tcgtcgtctg tcttttcctg     1260

ggcctttgcg atggcttctt catcaccatc atggccccca ttgcatttga gctggtgggc     1320

ccaatgcagg cctcacaggc cattggctac ctcctgggca tgatggccct gccaatgatt     1380

gctgggcccc ccattgcagg cctactccgc aactgttttg gggactacca tgtggccttc     1440

tactttgccg gtgtgccccc catcatcggg gctgtaatcc tcttcttcgt ccctctgatg     1500

catcaaagga tgttcaagaa agagcagaga gattccagca aggataagat gttggcccct     1560

gacccagacc ccaatgggga gctactgccg ggctccccca accctgagga accaatcgaa     1620

ttcgtcaccg acgccaaaaa cataaagaaa ggcccggcgc cattctatcc gctggaagat     1680

ggaaccgctg gagagcaact gcataaggct atgaagagat acgccctggt tcctggaaca     1740

attgctttta cagatgcaca tatcgaggtg gacatcactt acgctgagta cttcgaaatg     1800

tccgttcggt tggcagaagc tatgaaacga tatgggctga atacaaatca cagaatcgtc     1860

gtatgcagtg aaaactctct tcaattcttt atgccggtgt tgggcgcgtt atttatcgga     1920

gttgcagttg cgcccgcgaa cgacatttat aatgaacgtg aattgctcaa cagtatgggc     1980

atttcgcagc ctaccgtggt gttcgtttcc aaaaaggggt tgcaaaaaat tttgaacgtg     2040

caaaaaaagc tcccaatcat ccaaaaaatt attatcatgg attctaaaac ggattaccag     2100

ggatttcagt cgatgtacac gttcgtcaca tctcatctac ctcccggttt taatgaatac     2160

gattttgtgc cagagtcctt cgatagggac aagacaattg cactgatcat gaactcctct     2220

ggatctactg gtctgcctaa aggtgtcgct ctgcctcata gaactgcctg cgtgagattc     2280

tcgcatgcca gagatcctat ttttggcaat caaatcattc cggatactgc gattttaagt     2340

gttgttccat tccatcacgg ttttggaatg tttactacac tcggatattt gatatgtgga     2400

tttcgagtcg tcttaatgta tagatttgaa gaagagctgt ttctgaggag ccttcaggat     2460

tacaagattc aaagtgcgct gctggtgcca accctattct ccttcttcgc caaaagcact     2520

ctgattgaca aatacgattt atctaattta cacgaaattg cttctggtgg cgctcccctc     2580

tctaaggaag tcggggaagc ggttgccaag aggttccatc tgccaggtat caggcaagga     2640

tatgggctca ctgagactac atcagctatt ctgattacac ccgaggggga tgataaaccg     2700

ggcgcggtcg gtaaagttgt tccatttttt gaagcgaagg ttgtggatct ggataccggg     2760

aaaacgctgg gcgttaatca aagaggcgaa ctgtgtgtga gaggtcctat gattatgtcc     2820

ggttatgtaa acaatccgga agcgaccaac gccttgattg acaaggatgg atggctacat     2880

tctggagaca tagcttactg ggacgaagac gaacacttct tcatcgttga ccgcctgaag     2940

tctctgatta agtacaaagg ctatcaggtg gctcccgctg aattggaatc catcttgctc     3000

caacacccca acatcttcga cgcaggtgtc gcaggtcttc ccgacgatga cgccggtgaa     3060

cttcccgccg ccgttgttgt tttggagcac ggaaagacga tgacggaaaa agagatcgtg     3120

gattacgtcg ccagtcaagt aacaaccgcg aaaaagttgc gcggaggagt tgtgtttgtg     3180

gacgaagtac cgaaaggtct taccggaaaa ctcgacgcaa gaaaaatcag agagatcctc     3240

ataaaggcca agaagggcgg aaagatcgcc gtgtaa                               3276


<210> 11
<211> 1091
<212> PRT
<213> Artificial Sequence

<223> "Fusion"

<220> 
<223> Fusion

<400> 11
Met Ala Leu Gln Ser Gln Ala Ser Glu Glu Ala Lys Gly Pro Trp Gln 
1               5                   10                  15      
Glu Ala Asp Gln Glu Gln Gln Glu Pro Val Gly Ser Pro Glu Pro Glu 
            20                  25                  30          
Ser Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Pro Val Pro Pro 
        35                  40                  45              
Pro Glu Pro Gln Pro Glu Pro Gln Pro Leu Pro Asp Pro Ala Pro Leu 
    50                  55                  60                  
Pro Glu Leu Glu Phe Glu Ser Glu Arg Val His Glu Pro Glu Pro Thr 
65                  70                  75                  80  
Pro Thr Val Glu Thr Arg Gly Thr Ala Arg Gly Phe Gln Pro Pro Glu 
                85                  90                  95      
Gly Gly Phe Gly Trp Val Val Val Phe Ala Ala Thr Trp Cys Asn Gly 
            100                 105                 110         
Ser Ile Phe Gly Ile His Asn Ser Val Gly Ile Leu Tyr Ser Met Leu 
        115                 120                 125             
Leu Glu Glu Glu Lys Glu Lys Asn Arg Gln Val Glu Phe Gln Ala Ala 
    130                 135                 140                 
Trp Val Gly Ala Leu Ala Met Gly Met Ile Phe Phe Cys Ser Pro Ile 
145                 150                 155                 160 
Val Ser Ile Phe Thr Asp Arg Leu Gly Cys Arg Ile Thr Ala Thr Ala 
                165                 170                 175     
Gly Ala Ala Val Ala Phe Ile Gly Leu His Thr Ser Ser Phe Thr Ser 
            180                 185                 190         
Ser Leu Ser Leu Arg Tyr Phe Thr Tyr Gly Ile Leu Phe Gly Cys Gly 
        195                 200                 205             
Cys Ser Phe Ala Phe Gln Pro Ser Leu Val Ile Leu Gly His Tyr Phe 
    210                 215                 220                 
Gln Arg Arg Leu Gly Leu Ala Asn Gly Val Val Ser Ala Gly Ser Ser 
225                 230                 235                 240 
Ile Phe Ser Met Ser Phe Pro Phe Leu Ile Arg Met Leu Gly Asp Lys 
                245                 250                 255     
Ile Lys Leu Ala Gln Thr Phe Gln Val Leu Ser Thr Phe Met Phe Val 
            260                 265                 270         
Leu Met Leu Leu Ser Leu Thr Tyr Arg Pro Leu Leu Pro Ser Ser Gln 
        275                 280                 285             
Asp Thr Pro Ser Lys Arg Gly Val Arg Thr Leu His Gln Arg Phe Leu 
    290                 295                 300                 
Ala Gln Leu Arg Lys Tyr Phe Asn Met Arg Val Phe Arg Gln Arg Thr 
305                 310                 315                 320 
Tyr Arg Ile Trp Ala Phe Gly Ile Ala Ala Ala Ala Leu Gly Tyr Phe 
                325                 330                 335     
Val Pro Tyr Val His Leu Met Lys Tyr Val Glu Glu Glu Phe Ser Glu 
            340                 345                 350         
Ile Lys Glu Thr Trp Val Leu Leu Val Cys Ile Gly Ala Thr Ser Gly 
        355                 360                 365             
Leu Gly Arg Leu Val Ser Gly His Ile Ser Asp Ser Ile Pro Gly Leu 
    370                 375                 380                 
Lys Lys Ile Tyr Leu Gln Val Leu Ser Phe Leu Leu Leu Gly Leu Met 
385                 390                 395                 400 
Ser Met Met Ile Pro Leu Cys Arg Asp Phe Gly Gly Leu Ile Val Val 
                405                 410                 415     
Cys Leu Phe Leu Gly Leu Cys Asp Gly Phe Phe Ile Thr Ile Met Ala 
            420                 425                 430         
Pro Ile Ala Phe Glu Leu Val Gly Pro Met Gln Ala Ser Gln Ala Ile 
        435                 440                 445             
Gly Tyr Leu Leu Gly Met Met Ala Leu Pro Met Ile Ala Gly Pro Pro 
    450                 455                 460                 
Ile Ala Gly Leu Leu Arg Asn Cys Phe Gly Asp Tyr His Val Ala Phe 
465                 470                 475                 480 
Tyr Phe Ala Gly Val Pro Pro Ile Ile Gly Ala Val Ile Leu Phe Phe 
                485                 490                 495     
Val Pro Leu Met His Gln Arg Met Phe Lys Lys Glu Gln Arg Asp Ser 
            500                 505                 510         
Ser Lys Asp Lys Met Leu Ala Pro Asp Pro Asp Pro Asn Gly Glu Leu 
        515                 520                 525             
Leu Pro Gly Ser Pro Asn Pro Glu Glu Pro Ile Glu Phe Val Thr Asp 
    530                 535                 540                 
Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro Leu Glu Asp 
545                 550                 555                 560 
Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg Tyr Ala Leu 
                565                 570                 575     
Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu Val Asp Ile 
            580                 585                 590         
Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala Glu Ala Met 
        595                 600                 605             
Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val Cys Ser Glu 
    610                 615                 620                 
Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu Phe Ile Gly 
625                 630                 635                 640 
Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg Glu Leu Leu 
                645                 650                 655     
Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val Ser Lys Lys 
            660                 665                 670         
Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro Ile Ile Gln 
        675                 680                 685             
Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly Phe Gln Ser 
    690                 695                 700                 
Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe Asn Glu Tyr 
705                 710                 715                 720 
Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile Ala Leu Ile 
                725                 730                 735     
Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val Ala Leu Pro 
            740                 745                 750         
His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp Pro Ile Phe 
        755                 760                 765             
Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val Val Pro Phe 
    770                 775                 780                 
His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu Ile Cys Gly 
785                 790                 795                 800 
Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu Phe Leu Arg 
                805                 810                 815     
Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val Pro Thr Leu 
            820                 825                 830         
Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr Asp Leu Ser 
        835                 840                 845             
Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser Lys Glu Val 
    850                 855                 860                 
Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile Arg Gln Gly 
865                 870                 875                 880 
Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr Pro Glu Gly 
                885                 890                 895     
Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe Phe Glu Ala 
            900                 905                 910         
Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val Asn Gln Arg 
        915                 920                 925             
Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly Tyr Val Asn 
    930                 935                 940                 
Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly Trp Leu His 
945                 950                 955                 960 
Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe Phe Ile Val 
                965                 970                 975     
Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln Val Ala Pro 
            980                 985                 990         
Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile Phe Asp Ala 
        995                 1000                1005            
Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu Pro Ala Ala 
    1010                1015                1020                
Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys Glu Ile Val 
1025                1030                1035                1040
Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu Arg Gly Gly 
                1045                1050                1055    
Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly Lys Leu Asp 
            1060                1065                1070        
Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys Gly Gly Lys 
        1075                1080                1085            
Ile Ala Val 
    1090    

<210> 12
<211> 1548
<212> DNA
<213> Homo sapiens

<223> "CDS 176...1723 of NCBI NM_018593.4"

<220> 
<223> CDS 176...1723 of NCBI NM_018593.4

<400> 12
atggtgctct cccaggagga gccggactcc gcgcggggca cgagcgaggc gcagccgctc      60

ggccccgcgc ccacgggggc cgctccgccg cccggcccgg gaccctcgga cagccccgag     120

gcggctgtcg agaaggtgga ggtggagctg gcggggccgg cgaccgcgga gccccatgag     180

ccccccgaac cccccgaggg cggctggggc tggctggtga tgctggcggc catgtggtgc     240

aacgggtcgg tgttcggcat ccagaacgct tgcggggtgc tcttcgtgtc catgctggaa     300

accttcggct ccaaagacga tgacaagatg gtctttaaga cagcatgggt aggttctctc     360

tccatgggga tgattttctt ttgctgccca atagtcagcg tcttcacaga cctatttggt     420

tgtcggaaaa cagctgtcgt gggtgctgct gttggatttg ttgggctcat gtccagttct     480

tttgtaagtt ccatcgagcc tctgtacctt acctatggaa tcatatttgc ctgcggctgc     540

tcctttgcat accagccttc attggtcatt ttgggacact atttcaagaa gcgccttgga     600

ctggtgaatg gcattgtcac tgctggcagc agtgtcttca caatcctgct gcctttgctc     660

ttaagggttc tgattgacag cgtgggcctc ttttacacat tgagggtgct ctgcatcttc     720

atgtttgttc tctttctggc tggctttact taccgacctc ttgctaccag taccaaagat     780

aaagagagtg gaggtagcgg atcctccctc ttttccagga aaaagttcag tcctccaaaa     840

aaaattttca attttgccat cttcaaggtg acagcttatg cagtgtgggc agttggaata     900

ccacttgcac tttttggata ctttgtgcct tatgttcact tgatgaaaca tgtaaatgaa     960

agatttcaag atgaaaaaaa taaagaggtt gttctcatgt gcattggcgt cacttcagga    1020

gttggacgac tgctctttgg ccggattgca gattatgtgc ctggtgtgaa gaaggtttat    1080

ctacaggtac tctccttttt cttcattggt ctgatgtcca tgatgattcc tctgtgtagc    1140

atctttgggg ccctcattgc tgtgtgcctc atcatgggtc tcttcgatgg atgcttcatt    1200

tccattatgg ctcccatagc ctttgagtta gttggtgccc aggatgtctc ccaagcaatt    1260

ggatttctgc tcggattcat gtctataccc atgactgttg gcccacccat tgcagggtta    1320

cttcgtgaca aactgggctc ctatgatgtg gcattctacc tcgctggagt ccctcccctt    1380

attggaggtg ctgtgctttg ttttatcccg tggatccata gtaagaagca aagagagatc    1440

agtaaaacca ctggaaaaga aaagatggag aaaatgttgg aaaaccagaa ctctctgctg    1500

tcaagttcat ctggaatgtt caagaaagaa tctgactcta ttatttaa                 1548


<210> 13
<211> 32
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 13
attgcggccg caccatggtg ctctcccagg ag                                   32


<210> 14
<211> 43
<212> DNA
<213> Artificial Sequence

<223> "Primer"

<220> 
<223> Primer

<400> 14
gcgcgaattc aataatagag tcagattctt tcttgaacat tcc                       43


<210> 15
<211> 3204
<212> DNA
<213> Artificial Sequence

<223> "Coding Seq Fusionprotein"

<220> 
<223> Coding Seq Fusionprotein

<400> 15
atggtgctct cccaggagga gccggactcc gcgcggggca cgagcgaggc gcagccgctc       60

ggccccgcgc ccacgggggc cgctccgccg cccggcccgg gaccctcgga cagccccgag      120

gcggctgtcg agaaggtgga ggtggagctg gcggggccgg cgaccgcgga gccccatgag      180

ccccccgaac cccccgaggg cggctggggc tggctggtga tgctggcggc catgtggtgc      240

aacgggtcgg tgttcggcat ccagaacgct tgcggggtgc tcttcgtgtc catgctggaa      300

accttcggct ccaaagacga tgacaagatg gtctttaaga cagcatgggt aggttctctc      360

tccatgggga tgattttctt ttgctgccca atagtcagcg tcttcacaga cctatttggt      420

tgtcggaaaa cagctgtcgt gggtgctgct gttggatttg ttgggctcat gtccagttct      480

tttgtaagtt ccatcgagcc tctgtacctt acctatggaa tcatatttgc ctgcggctgc      540

tcctttgcat accagccttc attggtcatt ttgggacact atttcaagaa gcgccttgga      600

ctggtgaatg gcattgtcac tgctggcagc agtgtcttca caatcctgct gcctttgctc      660

ttaagggttc tgattgacag cgtgggcctc ttttacacat tgagggtgct ctgcatcttc      720

atgtttgttc tctttctggc tggctttact taccgacctc ttgctaccag taccaaagat      780

aaagagagtg gaggtagcgg atcctccctc ttttccagga aaaagttcag tcctccaaaa      840

aaaattttca attttgccat cttcaaggtg acagcttatg cagtgtgggc agttggaata      900

ccacttgcac tttttggata ctttgtgcct tatgttcact tgatgaaaca tgtaaatgaa      960

agatttcaag atgaaaaaaa taaagaggtt gttctcatgt gcattggcgt cacttcagga     1020

gttggacgac tgctctttgg ccggattgca gattatgtgc ctggtgtgaa gaaggtttat     1080

ctacaggtac tctccttttt cttcattggt ctgatgtcca tgatgattcc tctgtgtagc     1140

atctttgggg ccctcattgc tgtgtgcctc atcatgggtc tcttcgatgg atgcttcatt     1200

tccattatgg ctcccatagc ctttgagtta gttggtgccc aggatgtctc ccaagcaatt     1260

ggatttctgc tcggattcat gtctataccc atgactgttg gcccacccat tgcagggtta     1320

cttcgtgaca aactgggctc ctatgatgtg gcattctacc tcgctggagt ccctcccctt     1380

attggaggtg ctgtgctttg ttttatcccg tggatccata gtaagaagca aagagagatc     1440

agtaaaacca ctggaaaaga aaagatggag aaaatgttgg aaaaccagaa ctctctgctg     1500

tcaagttcat ctggaatgtt caagaaagaa tctgactcta ttattgaatt cgtcaccgac     1560

gccaaaaaca taaagaaagg cccggcgcca ttctatccgc tggaagatgg aaccgctgga     1620

gagcaactgc ataaggctat gaagagatac gccctggttc ctggaacaat tgcttttaca     1680

gatgcacata tcgaggtgga catcacttac gctgagtact tcgaaatgtc cgttcggttg     1740

gcagaagcta tgaaacgata tgggctgaat acaaatcaca gaatcgtcgt atgcagtgaa     1800

aactctcttc aattctttat gccggtgttg ggcgcgttat ttatcggagt tgcagttgcg     1860

cccgcgaacg acatttataa tgaacgtgaa ttgctcaaca gtatgggcat ttcgcagcct     1920

accgtggtgt tcgtttccaa aaaggggttg caaaaaattt tgaacgtgca aaaaaagctc     1980

ccaatcatcc aaaaaattat tatcatggat tctaaaacgg attaccaggg atttcagtcg     2040

atgtacacgt tcgtcacatc tcatctacct cccggtttta atgaatacga ttttgtgcca     2100

gagtccttcg atagggacaa gacaattgca ctgatcatga actcctctgg atctactggt     2160

ctgcctaaag gtgtcgctct gcctcataga actgcctgcg tgagattctc gcatgccaga     2220

gatcctattt ttggcaatca aatcattccg gatactgcga ttttaagtgt tgttccattc     2280

catcacggtt ttggaatgtt tactacactc ggatatttga tatgtggatt tcgagtcgtc     2340

ttaatgtata gatttgaaga agagctgttt ctgaggagcc ttcaggatta caagattcaa     2400

agtgcgctgc tggtgccaac cctattctcc ttcttcgcca aaagcactct gattgacaaa     2460

tacgatttat ctaatttaca cgaaattgct tctggtggcg ctcccctctc taaggaagtc     2520

ggggaagcgg ttgccaagag gttccatctg ccaggtatca ggcaaggata tgggctcact     2580

gagactacat cagctattct gattacaccc gagggggatg ataaaccggg cgcggtcggt     2640

aaagttgttc cattttttga agcgaaggtt gtggatctgg ataccgggaa aacgctgggc     2700

gttaatcaaa gaggcgaact gtgtgtgaga ggtcctatga ttatgtccgg ttatgtaaac     2760

aatccggaag cgaccaacgc cttgattgac aaggatggat ggctacattc tggagacata     2820

gcttactggg acgaagacga acacttcttc atcgttgacc gcctgaagtc tctgattaag     2880

tacaaaggct atcaggtggc tcccgctgaa ttggaatcca tcttgctcca acaccccaac     2940

atcttcgacg caggtgtcgc aggtcttccc gacgatgacg ccggtgaact tcccgccgcc     3000

gttgttgttt tggagcacgg aaagacgatg acggaaaaag agatcgtgga ttacgtcgcc     3060

agtcaagtaa caaccgcgaa aaagttgcgc ggaggagttg tgtttgtgga cgaagtaccg     3120

aaaggtctta ccggaaaact cgacgcaaga aaaatcagag agatcctcat aaaggccaag     3180

aagggcggaa agatcgccgt gtaa                                            3204


<210> 16
<211> 1067
<212> PRT
<213> Artificial Sequence

<223> "Fusion"

<220> 
<223> Fusion

<400> 16
Met Val Leu Ser Gln Glu Glu Pro Asp Ser Ala Arg Gly Thr Ser Glu 
1               5                   10                  15      
Ala Gln Pro Leu Gly Pro Ala Pro Thr Gly Ala Ala Pro Pro Pro Gly 
            20                  25                  30          
Pro Gly Pro Ser Asp Ser Pro Glu Ala Ala Val Glu Lys Val Glu Val 
        35                  40                  45              
Glu Leu Ala Gly Pro Ala Thr Ala Glu Pro His Glu Pro Pro Glu Pro 
    50                  55                  60                  
Pro Glu Gly Gly Trp Gly Trp Leu Val Met Leu Ala Ala Met Trp Cys 
65                  70                  75                  80  
Asn Gly Ser Val Phe Gly Ile Gln Asn Ala Cys Gly Val Leu Phe Val 
                85                  90                  95      
Ser Met Leu Glu Thr Phe Gly Ser Lys Asp Asp Asp Lys Met Val Phe 
            100                 105                 110         
Lys Thr Ala Trp Val Gly Ser Leu Ser Met Gly Met Ile Phe Phe Cys 
        115                 120                 125             
Cys Pro Ile Val Ser Val Phe Thr Asp Leu Phe Gly Cys Arg Lys Thr 
    130                 135                 140                 
Ala Val Val Gly Ala Ala Val Gly Phe Val Gly Leu Met Ser Ser Ser 
145                 150                 155                 160 
Phe Val Ser Ser Ile Glu Pro Leu Tyr Leu Thr Tyr Gly Ile Ile Phe 
                165                 170                 175     
Ala Cys Gly Cys Ser Phe Ala Tyr Gln Pro Ser Leu Val Ile Leu Gly 
            180                 185                 190         
His Tyr Phe Lys Lys Arg Leu Gly Leu Val Asn Gly Ile Val Thr Ala 
        195                 200                 205             
Gly Ser Ser Val Phe Thr Ile Leu Leu Pro Leu Leu Leu Arg Val Leu 
    210                 215                 220                 
Ile Asp Ser Val Gly Leu Phe Tyr Thr Leu Arg Val Leu Cys Ile Phe 
225                 230                 235                 240 
Met Phe Val Leu Phe Leu Ala Gly Phe Thr Tyr Arg Pro Leu Ala Thr 
                245                 250                 255     
Ser Thr Lys Asp Lys Glu Ser Gly Gly Ser Gly Ser Ser Leu Phe Ser 
            260                 265                 270         
Arg Lys Lys Phe Ser Pro Pro Lys Lys Ile Phe Asn Phe Ala Ile Phe 
        275                 280                 285             
Lys Val Thr Ala Tyr Ala Val Trp Ala Val Gly Ile Pro Leu Ala Leu 
    290                 295                 300                 
Phe Gly Tyr Phe Val Pro Tyr Val His Leu Met Lys His Val Asn Glu 
305                 310                 315                 320 
Arg Phe Gln Asp Glu Lys Asn Lys Glu Val Val Leu Met Cys Ile Gly 
                325                 330                 335     
Val Thr Ser Gly Val Gly Arg Leu Leu Phe Gly Arg Ile Ala Asp Tyr 
            340                 345                 350         
Val Pro Gly Val Lys Lys Val Tyr Leu Gln Val Leu Ser Phe Phe Phe 
        355                 360                 365             
Ile Gly Leu Met Ser Met Met Ile Pro Leu Cys Ser Ile Phe Gly Ala 
    370                 375                 380                 
Leu Ile Ala Val Cys Leu Ile Met Gly Leu Phe Asp Gly Cys Phe Ile 
385                 390                 395                 400 
Ser Ile Met Ala Pro Ile Ala Phe Glu Leu Val Gly Ala Gln Asp Val 
                405                 410                 415     
Ser Gln Ala Ile Gly Phe Leu Leu Gly Phe Met Ser Ile Pro Met Thr 
            420                 425                 430         
Val Gly Pro Pro Ile Ala Gly Leu Leu Arg Asp Lys Leu Gly Ser Tyr 
        435                 440                 445             
Asp Val Ala Phe Tyr Leu Ala Gly Val Pro Pro Leu Ile Gly Gly Ala 
    450                 455                 460                 
Val Leu Cys Phe Ile Pro Trp Ile His Ser Lys Lys Gln Arg Glu Ile 
465                 470                 475                 480 
Ser Lys Thr Thr Gly Lys Glu Lys Met Glu Lys Met Leu Glu Asn Gln 
                485                 490                 495     
Asn Ser Leu Leu Ser Ser Ser Ser Gly Met Phe Lys Lys Glu Ser Asp 
            500                 505                 510         
Ser Ile Ile Glu Phe Val Thr Asp Ala Lys Asn Ile Lys Lys Gly Pro 
        515                 520                 525             
Ala Pro Phe Tyr Pro Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His 
    530                 535                 540                 
Lys Ala Met Lys Arg Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr 
545                 550                 555                 560 
Asp Ala His Ile Glu Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met 
                565                 570                 575     
Ser Val Arg Leu Ala Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn 
            580                 585                 590         
His Arg Ile Val Val Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro 
        595                 600                 605             
Val Leu Gly Ala Leu Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp 
    610                 615                 620                 
Ile Tyr Asn Glu Arg Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro 
625                 630                 635                 640 
Thr Val Val Phe Val Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val 
                645                 650                 655     
Gln Lys Lys Leu Pro Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys 
            660                 665                 670         
Thr Asp Tyr Gln Gly Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His 
        675                 680                 685             
Leu Pro Pro Gly Phe Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp 
    690                 695                 700                 
Arg Asp Lys Thr Ile Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly 
705                 710                 715                 720 
Leu Pro Lys Gly Val Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe 
                725                 730                 735     
Ser His Ala Arg Asp Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr 
            740                 745                 750         
Ala Ile Leu Ser Val Val Pro Phe His His Gly Phe Gly Met Phe Thr 
        755                 760                 765             
Thr Leu Gly Tyr Leu Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg 
    770                 775                 780                 
Phe Glu Glu Glu Leu Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln 
785                 790                 795                 800 
Ser Ala Leu Leu Val Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr 
                805                 810                 815     
Leu Ile Asp Lys Tyr Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly 
            820                 825                 830         
Gly Ala Pro Leu Ser Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe 
        835                 840                 845             
His Leu Pro Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser 
    850                 855                 860                 
Ala Ile Leu Ile Thr Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly 
865                 870                 875                 880 
Lys Val Val Pro Phe Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly 
                885                 890                 895     
Lys Thr Leu Gly Val Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro 
            900                 905                 910         
Met Ile Met Ser Gly Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu 
        915                 920                 925             
Ile Asp Lys Asp Gly Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp 
    930                 935                 940                 
Glu Asp Glu His Phe Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys 
945                 950                 955                 960 
Tyr Lys Gly Tyr Gln Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu 
                965                 970                 975     
Gln His Pro Asn Ile Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp 
            980                 985                 990         
Asp Ala Gly Glu Leu Pro Ala Ala Val Val Val Leu Glu His Gly Lys 
        995                 1000                1005            
Thr Met Thr Glu Lys Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr 
    1010                1015                1020                
Thr Ala Lys Lys Leu Arg Gly Gly Val Val Phe Val Asp Glu Val Pro 
1025                1030                1035                1040
Lys Gly Leu Thr Gly Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu 
                1045                1050                1055    
Ile Lys Ala Lys Lys Gly Gly Lys Ile Ala Val 
            1060                1065        

