                         SEQUENCE LISTING

<110>  SIT Biotech GmbH
 
<120>  Selective cell death-inducing enzyme system

<130>  SIT126-12WO

<140>  not yet known
<141>  2018-03-13

<150>  EP17160694.0
<151>  2017-03-13

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  243
<212>  PRT
<213>  tobacco etch virus

<400>  1

Met Gly Glu Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser 
1               5                   10                  15      


Ser Thr Ile Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser 
            20                  25                  30          


Leu Tyr Gly Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu 
        35                  40                  45              


Phe Arg Arg Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val 
    50                  55                  60                  


Phe Lys Val Lys Asp Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly 
65                  70                  75                  80  


Arg Asp Met Met Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro 
                85                  90                  95      


Gln Lys Leu Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu 
            100                 105                 110         


Val Thr Thr Asn Phe Gln Ala Lys Ser Met Ser Ser Met Val Ser Asp 
        115                 120                 125             


Thr Ser Cys Thr Phe Pro Ser Ser Asp Gly Ile Phe Trp Lys His Trp 
    130                 135                 140                 


Ile Gln Thr Lys Asp Gly Gln Cys Gly Ser Pro Leu Val Ser Thr Arg 
145                 150                 155                 160 


Asp Gly Phe Ile Val Gly Ile His Ser Ala Ser Asn Phe Thr Asn Thr 
                165                 170                 175     


Asn Asn Tyr Phe Thr Ser Val Pro Lys Asn Phe Met Glu Leu Leu Thr 
            180                 185                 190         


Asn Gln Glu Ala Gln Gln Trp Val Ser Gly Trp Arg Leu Asn Ala Asp 
        195                 200                 205             


Ser Val Leu Trp Gly Gly His Lys Val Phe Met Val Lys Pro Glu Glu 
    210                 215                 220                 


Pro Phe Gln Pro Val Lys Glu Ala Thr Gln Leu Met Asn Glu Leu Val 
225                 230                 235                 240 


Tyr Ser Gln 
            


<210>  2
<211>  262
<212>  PRT
<213>  tobacco etch virus

<400>  2

Met Lys His His His His His His Pro Met Ser Gly Leu Val Pro Arg 
1               5                   10                  15      


Gly Ser Ala Met Gly Glu Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn 
            20                  25                  30          


Pro Ile Ser Ser Thr Ile Cys His Leu Thr Asn Glu Ser Asp Gly His 
        35                  40                  45              


Thr Thr Ser Leu Tyr Gly Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn 
    50                  55                  60                  


Lys His Leu Phe Arg Arg Asn Asn Gly Thr Leu Leu Val Gln Ser Leu 
65                  70                  75                  80  


His Gly Val Phe Lys Val Lys Asp Thr Thr Thr Leu Gln Gln His Leu 
                85                  90                  95      


Ile Asp Gly Arg Asp Met Met Ile Ile Arg Met Pro Lys Asp Phe Pro 
            100                 105                 110         


Pro Phe Pro Gln Lys Leu Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg 
        115                 120                 125             


Ile Cys Leu Val Thr Thr Asn Phe Gln Ala Lys Ser Met Ser Ser Met 
    130                 135                 140                 


Val Ser Asp Thr Ser Cys Thr Phe Pro Ser Ser Asp Gly Ile Phe Trp 
145                 150                 155                 160 


Lys His Trp Ile Gln Thr Lys Asp Gly Gln Cys Gly Ser Pro Leu Val 
                165                 170                 175     


Ser Thr Arg Asp Gly Phe Ile Val Gly Ile His Ser Ala Ser Asn Phe 
            180                 185                 190         


Thr Asn Thr Asn Asn Tyr Phe Thr Ser Val Pro Lys Asn Phe Met Glu 
        195                 200                 205             


Leu Leu Thr Asn Gln Glu Ala Gln Gln Trp Val Ser Gly Trp Arg Leu 
    210                 215                 220                 


Asn Ala Asp Ser Val Leu Trp Gly Gly His Lys Val Phe Met Val Lys 
225                 230                 235                 240 


Pro Glu Glu Pro Phe Gln Pro Val Lys Glu Ala Thr Gln Leu Met Asn 
                245                 250                 255     


Glu Leu Val Tyr Ser Gln 
            260         


<210>  3
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  TEV recognition site

<400>  3

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  TEV recognition site

<400>  4

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  5
<211>  272
<212>  PRT
<213>  Artificial

<220>
<223>  casapase 3 with TEV recognition site

<400>  5

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Met Thr Ser Arg Ser Gly Thr Asp Val Asp Ala Ala Asn Leu 
    50                  55                  60                  


Arg Glu Thr Phe Arg Asn Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp 
65                  70                  75                  80  


Leu Thr Arg Glu Glu Ile Val Glu Leu Met Arg Asp Val Ser Lys Glu 
                85                  90                  95      


Asp His Ser Lys Arg Ser Ser Phe Val Cys Val Leu Leu Ser His Gly 
            100                 105                 110         


Glu Glu Gly Ile Ile Phe Gly Thr Asn Gly Pro Val Asp Leu Lys Lys 
        115                 120                 125             


Ile Thr Asn Phe Phe Arg Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys 
    130                 135                 140                 


Pro Lys Leu Phe Ile Ile Gln Ala Cys Arg Cys Thr Glu Leu Asp Cys 
145                 150                 155                 160 


Gly Ile Glu Thr Glu Asn Leu Tyr Phe Gln Ser Gly Val Asp Asp Asp 
                165                 170                 175     


Met Ala Cys His Lys Ile Pro Val Glu Ala Asp Phe Leu Tyr Ala Tyr 
            180                 185                 190         


Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn Ser Lys Asp Gly Ser 
        195                 200                 205             


Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys Gln Tyr Ala Asp Lys 
    210                 215                 220                 


Leu Glu Phe Met His Ile Leu Thr Arg Val Asn Arg Lys Val Ala Thr 
225                 230                 235                 240 


Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe His Ala Lys Lys Gln 
                245                 250                 255     


Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Tyr His 
            260                 265                 270         


<210>  6
<211>  308
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 7 with TEV recognition site

<400>  6

Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser Ala 
1               5                   10                  15      


Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val Pro 
            20                  25                  30          


Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile Lys 
        35                  40                  45              


Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe Glu 
    50                  55                  60                  


Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys Val 
65                  70                  75                  80  


Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala Leu 
                85                  90                  95      


Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn Asp 
            100                 105                 110         


Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu Glu 
        115                 120                 125             


Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His Gly 
    130                 135                 140                 


Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys Asp 
145                 150                 155                 160 


Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu Lys 
                165                 170                 175     


Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp Asp 
            180                 185                 190         


Gly Ile Gln Ala Glu Asn Leu Tyr Phe Gln Ser Gly Pro Ile Asn Asp 
        195                 200                 205             


Thr Asp Ala Asn Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu 
    210                 215                 220                 


Phe Ala Tyr Ser Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly 
225                 230                 235                 240 


Arg Gly Ser Trp Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His 
                245                 250                 255     


Gly Lys Asp Leu Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg 
            260                 265                 270         


Val Ala Arg His Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu 
        275                 280                 285             


Lys Lys Gln Ile Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr 
    290                 295                 300                 


Gly Phe Ser Gln 
305             


<210>  7
<211>  265
<212>  PRT
<213>  Artificial

<220>
<223>  caspase 8 with TEV recognition site

<400>  7

Met Asp Ser Glu Ser Gln Thr Leu Asp Lys Val Tyr Gln Met Lys Ser 
1               5                   10                  15      


Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn Phe Ala Lys 
            20                  25                  30          


Ala Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp Arg Asn Gly 
        35                  40                  45              


Thr His Leu Asp Ala Gly Ala Leu Thr Thr Thr Phe Glu Glu Leu His 
    50                  55                  60                  


Phe Glu Ile Lys Pro His Asp Asp Cys Thr Val Glu Gln Ile Tyr Glu 
65                  70                  75                  80  


Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp Cys Phe 
                85                  90                  95      


Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr Gly Thr 
            100                 105                 110         


Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Thr Ser Gln Phe Thr Gly 
        115                 120                 125             


Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe Ile Gln 
    130                 135                 140                 


Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu Thr Asp 
145                 150                 155                 160 


Ser Glu Asn Leu Tyr Phe Gln Gly Met Asp Leu Ser Ser Pro Gln Thr 
                165                 170                 175     


Arg Tyr Ile Pro Asp Glu Ala Asp Phe Leu Leu Gly Met Ala Thr Val 
            180                 185                 190         


Asn Asn Cys Val Ser Tyr Arg Asn Pro Ala Glu Gly Thr Trp Tyr Ile 
        195                 200                 205             


Gln Ser Leu Cys Gln Ser Leu Arg Glu Arg Cys Pro Arg Gly Asp Asp 
    210                 215                 220                 


Ile Leu Thr Ile Leu Thr Glu Val Asn Tyr Glu Val Ser Asn Lys Asp 
225                 230                 235                 240 


Asp Lys Lys Asn Met Gly Lys Gln Met Pro Gln Pro Thr Phe Thr Leu 
                245                 250                 255     


Arg Lys Lys Leu Val Phe Pro Ser Asp 
            260                 265 


<210>  8
<211>  305
<212>  PRT
<213>  Artificial

<220>
<223>  casapase 10 with TEV recognition site

<400>  8

Met Asp Val Lys Thr Phe Leu Glu Ala Leu Pro Gln Glu Ser Trp Gln 
1               5                   10                  15      


Asn Lys His Ala Gly Ser Asn Gly Asn Arg Ala Thr Asn Gly Ala Pro 
            20                  25                  30          


Ser Leu Val Ser Arg Gly Met Gln Gly Ala Ser Ala Asn Thr Leu Asn 
        35                  40                  45              


Ser Glu Thr Ser Thr Lys Arg Ala Ala Val Tyr Arg Met Asn Arg Asn 
    50                  55                  60                  


His Arg Gly Leu Cys Val Ile Val Asn Asn His Ser Phe Thr Ser Leu 
65                  70                  75                  80  


Lys Asp Arg Gln Gly Thr His Lys Asp Ala Glu Ile Leu Ser His Val 
                85                  90                  95      


Phe Gln Trp Leu Gly Phe Thr Val His Ile His Asn Asn Val Thr Lys 
            100                 105                 110         


Val Glu Met Glu Met Val Leu Gln Lys Gln Lys Cys Asn Pro Ala His 
        115                 120                 125             


Ala Asp Gly Asp Cys Phe Val Phe Cys Ile Leu Thr His Gly Arg Phe 
    130                 135                 140                 


Gly Ala Val Tyr Ser Ser Asp Glu Ala Leu Ile Pro Ile Arg Glu Ile 
145                 150                 155                 160 


Met Ser His Phe Thr Ala Leu Gln Cys Pro Arg Leu Ala Glu Lys Pro 
                165                 170                 175     


Lys Leu Phe Phe Ile Gln Ala Cys Gln Gly Glu Glu Ile Gln Pro Ser 
            180                 185                 190         


Val Ser Ile Glu Ala Glu Asn Leu Tyr Phe Gln Gly Gln Ala Pro Thr 
        195                 200                 205             


Ser Leu Gln Asp Ser Ile Pro Ala Glu Ala Asp Phe Leu Leu Gly Leu 
    210                 215                 220                 


Ala Thr Val Pro Gly Tyr Val Ser Phe Arg His Val Glu Glu Gly Ser 
225                 230                 235                 240 


Trp Tyr Ile Gln Ser Leu Cys Asn His Leu Lys Lys Leu Val Pro Arg 
                245                 250                 255     


Met Leu Lys Phe Leu Glu Lys Thr Met Glu Ile Arg Gly Arg Lys Arg 
            260                 265                 270         


Thr Val Trp Gly Ala Lys Gln Ile Ser Ala Thr Ser Leu Pro Thr Ala 
        275                 280                 285             


Ile Ser Ala Gln Thr Pro Arg Pro Pro Met Arg Arg Trp Ser Ser Val 
    290                 295                 300                 


Ser 
305 


<210>  9
<211>  170
<212>  PRT
<213>  Artificial

<220>
<223>  Cleaved Part of caspase 3 by TEV

<400>  9

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Met Thr Ser Arg Ser Gly Thr Asp Val Asp Ala Ala Asn Leu 
    50                  55                  60                  


Arg Glu Thr Phe Arg Asn Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp 
65                  70                  75                  80  


Leu Thr Arg Glu Glu Ile Val Glu Leu Met Arg Asp Val Ser Lys Glu 
                85                  90                  95      


Asp His Ser Lys Arg Ser Ser Phe Val Cys Val Leu Leu Ser His Gly 
            100                 105                 110         


Glu Glu Gly Ile Ile Phe Gly Thr Asn Gly Pro Val Asp Leu Lys Lys 
        115                 120                 125             


Ile Thr Asn Phe Phe Arg Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys 
    130                 135                 140                 


Pro Lys Leu Phe Ile Ile Gln Ala Cys Arg Cys Thr Glu Leu Asp Cys 
145                 150                 155                 160 


Gly Ile Glu Thr Glu Asn Leu Tyr Phe Gln 
                165                 170 


<210>  10
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  Cleaved part of caspase 3 by TEV

<400>  10

Ser Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala 
1               5                   10                  15      


Asp Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg 
            20                  25                  30          


Asn Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu 
        35                  40                  45              


Lys Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val 
    50                  55                  60                  


Asn Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr 
65                  70                  75                  80  


Phe His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys 
                85                  90                  95      


Glu Leu Tyr Phe Tyr His 
            100         


<210>  11
<211>  202
<212>  PRT
<213>  Artificial

<220>
<223>  Cleaved part of caspase 7 by TEV

<400>  11

Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser Ala 
1               5                   10                  15      


Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val Pro 
            20                  25                  30          


Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile Lys 
        35                  40                  45              


Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe Glu 
    50                  55                  60                  


Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys Val 
65                  70                  75                  80  


Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala Leu 
                85                  90                  95      


Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn Asp 
            100                 105                 110         


Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu Glu 
        115                 120                 125             


Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His Gly 
    130                 135                 140                 


Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys Asp 
145                 150                 155                 160 


Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu Lys 
                165                 170                 175     


Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp Asp 
            180                 185                 190         


Gly Ile Gln Ala Glu Asn Leu Tyr Phe Gln 
        195                 200         


<210>  12
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Cleaved part of caspase 7 by TEV

<400>  12

Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn Pro Arg Tyr Lys Ile Pro 
1               5                   10                  15      


Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser Thr Val Pro Gly Tyr Tyr 
            20                  25                  30          


Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp Phe Val Gln Ala Leu Cys 
        35                  40                  45              


Ser Ile Leu Glu Glu His Gly Lys Asp Leu Glu Ile Met Gln Ile Leu 
    50                  55                  60                  


Thr Arg Val Asn Asp Arg Val Ala Arg His Phe Glu Ser Gln Ser Asp 
65                  70                  75                  80  


Asp Pro His Phe His Glu Lys Lys Gln Ile Pro Cys Val Val Ser Met 
                85                  90                  95      


Leu Thr Lys Glu Leu Tyr Gly Phe Ser Gln 
            100                 105     


<210>  13
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  Cleaved part of caspase 8 by TEV

<400>  13

Met Asp Ser Glu Ser Gln Thr Leu Asp Lys Val Tyr Gln Met Lys Ser 
1               5                   10                  15      


Lys Pro Arg Gly Tyr Cys Leu Ile Ile Asn Asn His Asn Phe Ala Lys 
            20                  25                  30          


Ala Arg Glu Lys Val Pro Lys Leu His Ser Ile Arg Asp Arg Asn Gly 
        35                  40                  45              


Thr His Leu Asp Ala Gly Ala Leu Thr Thr Thr Phe Glu Glu Leu His 
    50                  55                  60                  


Phe Glu Ile Lys Pro His Asp Asp Cys Thr Val Glu Gln Ile Tyr Glu 
65                  70                  75                  80  


Ile Leu Lys Ile Tyr Gln Leu Met Asp His Ser Asn Met Asp Cys Phe 
                85                  90                  95      


Ile Cys Cys Ile Leu Ser His Gly Asp Lys Gly Ile Ile Tyr Gly Thr 
            100                 105                 110         


Asp Gly Gln Glu Ala Pro Ile Tyr Glu Leu Thr Ser Gln Phe Thr Gly 
        115                 120                 125             


Leu Lys Cys Pro Ser Leu Ala Gly Lys Pro Lys Val Phe Phe Ile Gln 
    130                 135                 140                 


Ala Cys Gln Gly Asp Asn Tyr Gln Lys Gly Ile Pro Val Glu Thr Asp 
145                 150                 155                 160 


Ser Glu Asn Leu Tyr Phe Gln 
                165         


<210>  14
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Cleaved part of caspase 8 by TEV

<400>  14

Gly Met Asp Leu Ser Ser Pro Gln Thr Arg Tyr Ile Pro Asp Glu Ala 
1               5                   10                  15      


Asp Phe Leu Leu Gly Met Ala Thr Val Asn Asn Cys Val Ser Tyr Arg 
            20                  25                  30          


Asn Pro Ala Glu Gly Thr Trp Tyr Ile Gln Ser Leu Cys Gln Ser Leu 
        35                  40                  45              


Arg Glu Arg Cys Pro Arg Gly Asp Asp Ile Leu Thr Ile Leu Thr Glu 
    50                  55                  60                  


Val Asn Tyr Glu Val Ser Asn Lys Asp Asp Lys Lys Asn Met Gly Lys 
65                  70                  75                  80  


Gln Met Pro Gln Pro Thr Phe Thr Leu Arg Lys Lys Leu Val Phe Pro 
                85                  90                  95      


Ser Asp 
        


<210>  15
<211>  203
<212>  PRT
<213>  Artificial

<220>
<223>  Cleaved part of caspase 10 by TEV

<400>  15

Met Asp Val Lys Thr Phe Leu Glu Ala Leu Pro Gln Glu Ser Trp Gln 
1               5                   10                  15      


Asn Lys His Ala Gly Ser Asn Gly Asn Arg Ala Thr Asn Gly Ala Pro 
            20                  25                  30          


Ser Leu Val Ser Arg Gly Met Gln Gly Ala Ser Ala Asn Thr Leu Asn 
        35                  40                  45              


Ser Glu Thr Ser Thr Lys Arg Ala Ala Val Tyr Arg Met Asn Arg Asn 
    50                  55                  60                  


His Arg Gly Leu Cys Val Ile Val Asn Asn His Ser Phe Thr Ser Leu 
65                  70                  75                  80  


Lys Asp Arg Gln Gly Thr His Lys Asp Ala Glu Ile Leu Ser His Val 
                85                  90                  95      


Phe Gln Trp Leu Gly Phe Thr Val His Ile His Asn Asn Val Thr Lys 
            100                 105                 110         


Val Glu Met Glu Met Val Leu Gln Lys Gln Lys Cys Asn Pro Ala His 
        115                 120                 125             


Ala Asp Gly Asp Cys Phe Val Phe Cys Ile Leu Thr His Gly Arg Phe 
    130                 135                 140                 


Gly Ala Val Tyr Ser Ser Asp Glu Ala Leu Ile Pro Ile Arg Glu Ile 
145                 150                 155                 160 


Met Ser His Phe Thr Ala Leu Gln Cys Pro Arg Leu Ala Glu Lys Pro 
                165                 170                 175     


Lys Leu Phe Phe Ile Gln Ala Cys Gln Gly Glu Glu Ile Gln Pro Ser 
            180                 185                 190         


Val Ser Ile Glu Ala Glu Asn Leu Tyr Phe Gln 
        195                 200             


<210>  16
<211>  102
<212>  PRT
<213>  Artificial

<220>
<223>  Cleaved part of caspase 10 by TEV

<400>  16

Gly Gln Ala Pro Thr Ser Leu Gln Asp Ser Ile Pro Ala Glu Ala Asp 
1               5                   10                  15      


Phe Leu Leu Gly Leu Ala Thr Val Pro Gly Tyr Val Ser Phe Arg His 
            20                  25                  30          


Val Glu Glu Gly Ser Trp Tyr Ile Gln Ser Leu Cys Asn His Leu Lys 
        35                  40                  45              


Lys Leu Val Pro Arg Met Leu Lys Phe Leu Glu Lys Thr Met Glu Ile 
    50                  55                  60                  


Arg Gly Arg Lys Arg Thr Val Trp Gly Ala Lys Gln Ile Ser Ala Thr 
65                  70                  75                  80  


Ser Leu Pro Thr Ala Ile Ser Ala Gln Thr Pro Arg Pro Pro Met Arg 
                85                  90                  95      


Arg Trp Ser Ser Val Ser 
            100         


<210>  17
<211>  163
<212>  PRT
<213>  SMAC

<400>  17

Met Ala Val Pro Ile Ala Gln Lys Ser Glu Pro His Ser Leu Ser Ser 
1               5                   10                  15      


Glu Ala Leu Met Arg Arg Ala Val Ser Leu Val Thr Asp Ser Thr Ser 
            20                  25                  30          


Thr Phe Leu Ser Gln Thr Thr Tyr Ala Leu Ile Glu Ala Ile Thr Glu 
        35                  40                  45              


Tyr Thr Lys Ala Val Tyr Thr Leu Thr Ser Leu Tyr Arg Gln Tyr Thr 
    50                  55                  60                  


Ser Leu Leu Gly Lys Met Asn Ser Glu Glu Glu Asp Glu Val Trp Gln 
65                  70                  75                  80  


Val Ile Ile Gly Ala Arg Ala Glu Met Thr Ser Lys His Gln Glu Tyr 
                85                  90                  95      


Leu Lys Leu Glu Thr Thr Trp Met Thr Ala Val Gly Leu Ser Glu Met 
            100                 105                 110         


Ala Ala Glu Ala Ala Tyr Gln Thr Gly Ala Asp Gln Ala Ser Ile Thr 
        115                 120                 125             


Ala Arg Asn His Ile Gln Leu Val Lys Leu Gln Val Glu Glu Val His 
    130                 135                 140                 


Gln Leu Ser Arg Lys Ala Glu Thr Lys Leu Ala Glu Ala Gln Ile Glu 
145                 150                 155                 160 


Glu Leu Arg 
            


<210>  18
<211>  301
<212>  PRT
<213>  XAF1

<400>  18

Met Glu Gly Asp Phe Ser Val Cys Arg Asn Cys Lys Arg His Val Val 
1               5                   10                  15      


Ser Ala Asn Phe Thr Leu His Glu Ala Tyr Cys Leu Arg Phe Leu Val 
            20                  25                  30          


Leu Cys Pro Glu Cys Glu Glu Pro Val Pro Lys Glu Thr Met Glu Glu 
        35                  40                  45              


His Cys Lys Leu Glu His Gln Gln Val Gly Cys Thr Met Cys Gln Gln 
    50                  55                  60                  


Ser Met Gln Lys Ser Ser Leu Glu Phe His Lys Ala Asn Glu Cys Gln 
65                  70                  75                  80  


Glu Arg Pro Val Glu Cys Lys Phe Cys Lys Leu Asp Met Gln Leu Ser 
                85                  90                  95      


Lys Leu Glu Leu His Glu Ser Tyr Cys Gly Ser Arg Thr Glu Leu Cys 
            100                 105                 110         


Gln Gly Cys Gly Gln Phe Ile Met His Arg Met Leu Ala Gln His Arg 
        115                 120                 125             


Asp Val Cys Arg Ser Glu Gln Ala Gln Leu Gly Lys Gly Glu Arg Ile 
    130                 135                 140                 


Ser Ala Pro Glu Arg Glu Ile Tyr Cys His Tyr Cys Asn Gln Met Ile 
145                 150                 155                 160 


Pro Glu Asn Lys Tyr Phe His His Met Gly Lys Cys Cys Pro Asp Ser 
                165                 170                 175     


Glu Phe Lys Lys His Phe Pro Val Gly Asn Pro Glu Ile Leu Pro Ser 
            180                 185                 190         


Ser Leu Pro Ser Gln Ala Ala Glu Asn Gln Thr Ser Thr Met Glu Lys 
        195                 200                 205             


Asp Val Arg Pro Lys Thr Arg Ser Ile Asn Arg Phe Pro Leu His Ser 
    210                 215                 220                 


Glu Ser Ser Ser Lys Lys Ala Pro Arg Ser Lys Asn Lys Thr Leu Asp 
225                 230                 235                 240 


Pro Leu Leu Met Ser Glu Pro Lys Pro Arg Thr Ser Ser Pro Arg Gly 
                245                 250                 255     


Asp Lys Ala Ala Tyr Asp Ile Leu Arg Arg Cys Ser Gln Cys Gly Ile 
            260                 265                 270         


Leu Leu Pro Leu Pro Ile Leu Asn Gln His Gln Glu Lys Cys Arg Trp 
        275                 280                 285             


Leu Ala Ser Ser Lys Gly Lys Gln Val Arg Asn Phe Ser 
    290                 295                 300     


<210>  19
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  fusion proetin

<400>  19

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Cys Thr Glu Leu Asp Cys Gly Ile Glu Thr Glu Asn 
                165                 170                 175     


Leu Tyr Phe Gln Ser Gly Val Asp Asp Asp Met Ala Cys His Lys Ile 
            180                 185                 190         


Pro Val Glu Ala Asp Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr 
        195                 200                 205             


Tyr Ser Trp Arg Asn Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu 
    210                 215                 220                 


Cys Ala Met Leu Lys Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile 
225                 230                 235                 240 


Leu Thr Arg Val Asn Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser 
                245                 250                 255     


Phe Asp Ala Thr Phe His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser 
            260                 265                 270         


Met Leu Thr Lys Glu Leu Tyr Phe Tyr His Gly Ala Gly Ala Gly Asp 
        275                 280                 285             


Tyr Lys Asp Asp Asp Asp Lys Gly Asp Tyr Lys Asp Asp Asp Asp Lys 
    290                 295                 300                 


Ala Ala Ala Gly Gly Glu Asn Leu Tyr Phe Gln Ala Gly Ala Gly Ala 
305                 310                 315                 320 


Met Gly Ala Gly Ala Gly Glu Asn Leu Tyr Phe Gln Ala Asp Asp Gln 
                325                 330                 335     


Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser Ala Asn Glu Asp Ser 
            340                 345                 350         


Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val Pro Ser Leu Phe Ser 
        355                 360                 365             


Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile Lys Thr Thr Arg Asp 
    370                 375                 380                 


Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe Glu Lys Leu Gly Lys 
385                 390                 395                 400 


Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys Val Thr Gly Met Gly 
                405                 410                 415     


Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala Leu Phe Lys Cys Phe 
            420                 425                 430         


Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn Asp Cys Ser Cys Ala 
        435                 440                 445             


Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu Glu Asp His Thr Asn 
    450                 455                 460                 


Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His Gly Glu Glu Asn Val 
465                 470                 475                 480 


Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys Asp Leu Thr Ala His 
                485                 490                 495     


Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu Lys Pro Lys Leu Phe 
            500                 505                 510         


Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp Asp Gly Ile Gln Ala 
        515                 520                 525             


Glu Asn Leu Tyr Phe Gln Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn 
    530                 535                 540                 


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
545                 550                 555                 560 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
                565                 570                 575     


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
            580                 585                 590         


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
        595                 600                 605             


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
    610                 615                 620                 


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Gly Phe Ser Gln 
625                 630                 635                 640 


Gly Gly Gly Ala Ala Ala Gly Ala Gly Ala Gly Asp Tyr Lys Asp Asp 
                645                 650                 655     


Asp Asp Lys Gly Asp Tyr Lys Asp Asp Asp Asp Lys Ala Ala Ala Gly 
            660                 665                 670         


Gly Glu Asn Leu Tyr Phe Gln Ala Gly Ala Gly Ala Met Ala Val Pro 
        675                 680                 685             


Ile Ala Gln Lys Ser Glu Pro His Ser Leu Ser Ser Glu Ala Leu Met 
    690                 695                 700                 


Arg Arg Ala Val Ser Leu Val Thr Asp Ser Thr Ser Thr Phe Leu Ser 
705                 710                 715                 720 


Gln Thr Thr Tyr Ala Leu Ile Glu Ala Ile Thr Glu Tyr Thr Lys Ala 
                725                 730                 735     


Val Tyr Thr Leu Thr Ser Leu Tyr Arg Gln Tyr Thr Ser Leu Leu Gly 
            740                 745                 750         


Lys Met Asn Ser Glu Glu Glu Asp Glu Val Trp Gln Val Ile Ile Gly 
        755                 760                 765             


Ala Arg Ala Glu Met Thr Ser Lys His Gln Glu Tyr Leu Lys Leu Glu 
    770                 775                 780                 


Thr Thr Trp Met Thr Ala Val Gly Leu Ser Glu Met Ala Ala Glu Ala 
785                 790                 795                 800 


Ala Tyr Gln Thr Gly Ala Asp Gln Ala Ser Ile Thr Ala Arg Asn His 
                805                 810                 815     


Ile Gln Leu Val Lys Leu Gln Val Glu Glu Val His Gln Leu Ser Arg 
            820                 825                 830         


Lys Ala Glu Thr Lys Leu Ala Glu Ala Gln Ile Glu Glu Leu Arg Gly 
        835                 840                 845             


Ala Gly Ala Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Asp Tyr Lys 
    850                 855                 860                 


Asp Asp Asp Asp Lys Ala Ala Ala Gly Gly Glu Asn Leu Tyr Phe Gln 
865                 870                 875                 880 


Ala Gly Ala Gly Ala Met Glu Asn Leu Tyr Phe Gln Ser Ala Gly Ala 
                885                 890                 895     


Gly Ala Gly Glu Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile 
            900                 905                 910         


Ser Ser Thr Ile Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr 
        915                 920                 925             


Ser Leu Tyr Gly Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His 
    930                 935                 940                 


Leu Phe Arg Arg Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly 
945                 950                 955                 960 


Val Phe Lys Val Lys Asp Thr Thr Thr Leu Gln Gln His Leu Ile Asp 
                965                 970                 975     


Gly Arg Asp Met Met Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe 
            980                 985                 990         


Pro Gln Lys Leu Lys Phe Arg Glu  Pro Gln Arg Glu Glu  Arg Ile Cys 
        995                 1000                 1005             


Leu Val  Thr Thr Asn Phe Gln  Ala Lys Ser Met Ser  Ser Met Val 
    1010                 1015                 1020             


Ser Asp  Thr Ser Cys Thr Phe  Pro Ser Ser Asp Gly  Ile Phe Trp 
    1025                 1030                 1035             


Lys His  Trp Ile Gln Thr Lys  Asp Gly Gln Cys Gly  Ser Pro Leu 
    1040                 1045                 1050             


Val Ser  Thr Arg Asp Gly Phe  Ile Val Gly Ile His  Ser Ala Ser 
    1055                 1060                 1065             


Asn Phe  Thr Asn Thr Asn Asn  Tyr Phe Thr Ser Val  Pro Lys Asn 
    1070                 1075                 1080             


Phe Met  Glu Leu Leu Thr Asn  Gln Glu Ala Gln Gln  Trp Val Ser 
    1085                 1090                 1095             


Gly Trp  Arg Leu Asn Ala Asp  Ser Val Leu Trp Gly  Gly His Lys 
    1100                 1105                 1110             


Val Phe  Met Val Lys Pro Glu  Glu Pro Phe Gln Pro  Val Lys Glu 
    1115                 1120                 1125             


Ala Thr  Gln Leu Met Asn Glu  Leu Val Tyr Ser Gln  Gly Ala Gly 
    1130                 1135                 1140             


Ala Gly  Ala Gly 
    1145         


