                         SEQUENCE LISTING

<110>  DiaMedica, Inc.
       Pauls, Rick
       Verdoorn, Todd
 
<120>  DOSAGE FORMS OF TISSUE KALLIKREIN 1

<130>  DIAM-037/03WO 316251-2175

<150>  US 62/567,406
<151>  2017-10-03

<150>  US 62/516,463
<151>  2017-06-07

<150>  US 62/469,385
<151>  2017-03-09

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Phe Leu Val Leu Cys Leu Ala Leu Ser Leu Gly Gly Thr Gly 
1               5                   10                  15      


Ala Ala Pro Pro Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Gln His Ser Gln Pro Trp Gln Ala Ala Leu Tyr His Phe Ser Thr Phe 
        35                  40                  45              


Gln Cys Gly Gly Ile Leu Val His Arg Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Ser Asp Asn Tyr Gln Leu Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Asp Asp Glu Asn Thr Ala Gln Phe Val His Val Ser Glu Ser Phe 
                85                  90                  95      


Pro His Pro Gly Phe Asn Met Ser Leu Leu Glu Asn His Thr Arg Gln 
            100                 105                 110         


Ala Asp Glu Asp Tyr Ser His Asp Leu Met Leu Leu Arg Leu Thr Glu 
        115                 120                 125             


Pro Ala Asp Thr Ile Thr Asp Ala Val Lys Val Val Glu Leu Pro Thr 
    130                 135                 140                 


Glu Glu Pro Glu Val Gly Ser Thr Cys Leu Ala Ser Gly Trp Gly Ser 
145                 150                 155                 160 


Ile Glu Pro Glu Asn Phe Ser Phe Pro Asp Asp Leu Gln Cys Val Asp 
                165                 170                 175     


Leu Lys Ile Leu Pro Asn Asp Glu Cys Lys Lys Ala His Val Gln Lys 
            180                 185                 190         


Val Thr Asp Phe Met Leu Cys Val Gly His Leu Glu Gly Gly Lys Asp 
        195                 200                 205             


Thr Cys Val Gly Asp Ser Gly Gly Pro Leu Met Cys Asp Gly Val Leu 
    210                 215                 220                 


Gln Gly Val Thr Ser Trp Gly Tyr Val Pro Cys Gly Thr Pro Asn Lys 
225                 230                 235                 240 


Pro Ser Val Ala Val Arg Val Leu Ser Tyr Val Lys Trp Ile Glu Asp 
                245                 250                 255     


Thr Ile Ala Glu Asn Ser 
            260         


<210>  2
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Phe Leu Val Leu Cys Leu Ala Leu Ser Leu Gly Gly Thr Gly 
1               5                   10                  15      


Ala Ala Pro Pro Ile Gln Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Gln His Ser Gln Pro Trp Gln Ala Ala Leu Tyr His Phe Ser Thr Phe 
        35                  40                  45              


Gln Cys Gly Gly Ile Leu Val His Arg Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Ser Asp Asn Tyr Gln Leu Trp Leu Gly Arg His Asn Leu 
65                  70                  75                  80  


Phe Asp Asp Glu Asn Thr Ala Gln Phe Val His Val Ser Glu Ser Phe 
                85                  90                  95      


Pro His Pro Gly Phe Asn Met Ser Leu Leu Glu Asn His Thr Arg Gln 
            100                 105                 110         


Ala Asp Glu Asp Tyr Ser His Asp Leu Met Leu Leu Arg Leu Thr Glu 
        115                 120                 125             


Pro Ala Asp Thr Ile Thr Asp Ala Val Lys Val Val Glu Leu Pro Thr 
    130                 135                 140                 


Gln Glu Pro Glu Val Gly Ser Thr Cys Leu Ala Ser Gly Trp Gly Ser 
145                 150                 155                 160 


Ile Glu Pro Glu Asn Phe Ser Phe Pro Asp Asp Leu Gln Cys Val Asp 
                165                 170                 175     


Leu Lys Ile Leu Pro Asn Asp Glu Cys Lys Lys Val His Val Gln Lys 
            180                 185                 190         


Val Thr Asp Phe Met Leu Cys Val Gly His Leu Glu Gly Gly Lys Asp 
        195                 200                 205             


Thr Cys Val Gly Asp Ser Gly Gly Pro Leu Met Cys Asp Gly Val Leu 
    210                 215                 220                 


Gln Gly Val Thr Ser Trp Gly Tyr Val Pro Cys Gly Thr Pro Asn Lys 
225                 230                 235                 240 


Pro Ser Val Ala Val Arg Val Leu Ser Tyr Val Lys Trp Ile Glu Asp 
                245                 250                 255     


Thr Ile Ala Glu Asn Ser 
            260         


<210>  3
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Val Gly Gly Trp Glu Cys Glu Gln His Ser Gln Pro Trp Gln Ala 
1               5                   10                  15      


Ala Leu Tyr His Phe Ser Thr Phe Gln Cys Gly Gly Ile Leu Val His 
            20                  25                  30          


Arg Gln Trp Val Leu Thr Ala Ala His Cys Ile Ser Asp Asn Tyr Gln 
        35                  40                  45              


Leu Trp Leu Gly Arg His Asn Leu Phe Asp Asp Glu Asn Thr Ala Gln 
    50                  55                  60                  


Phe Val His Val Ser Glu Ser Phe Pro His Pro Gly Phe Asn Met Ser 
65                  70                  75                  80  


Leu Leu Glu Asn His Thr Arg Gln Ala Asp Glu Asp Tyr Ser His Asp 
                85                  90                  95      


Leu Met Leu Leu Arg Leu Thr Glu Pro Ala Asp Thr Ile Thr Asp Ala 
            100                 105                 110         


Val Lys Val Val Glu Leu Pro Thr Glu Glu Pro Glu Val Gly Ser Thr 
        115                 120                 125             


Cys Leu Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Asn Phe Ser Phe 
    130                 135                 140                 


Pro Asp Asp Leu Gln Cys Val Asp Leu Lys Ile Leu Pro Asn Asp Glu 
145                 150                 155                 160 


Cys Lys Lys Ala His Val Gln Lys Val Thr Asp Phe Met Leu Cys Val 
                165                 170                 175     


Gly His Leu Glu Gly Gly Lys Asp Thr Cys Val Gly Asp Ser Gly Gly 
            180                 185                 190         


Pro Leu Met Cys Asp Gly Val Leu Gln Gly Val Thr Ser Trp Gly Tyr 
        195                 200                 205             


Val Pro Cys Gly Thr Pro Asn Lys Pro Ser Val Ala Val Arg Val Leu 
    210                 215                 220                 


Ser Tyr Val Lys Trp Ile Glu Asp Thr Ile Ala Glu Asn Ser 
225                 230                 235             


<210>  4
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Val Gly Gly Trp Glu Cys Glu Gln His Ser Gln Pro Trp Gln Ala 
1               5                   10                  15      


Ala Leu Tyr His Phe Ser Thr Phe Gln Cys Gly Gly Ile Leu Val His 
            20                  25                  30          


Arg Gln Trp Val Leu Thr Ala Ala His Cys Ile Ser Asp Asn Tyr Gln 
        35                  40                  45              


Leu Trp Leu Gly Arg His Asn Leu Phe Asp Asp Glu Asn Thr Ala Gln 
    50                  55                  60                  


Phe Val His Val Ser Glu Ser Phe Pro His Pro Gly Phe Asn Met Ser 
65                  70                  75                  80  


Leu Leu Glu Asn His Thr Arg Gln Ala Asp Glu Asp Tyr Ser His Asp 
                85                  90                  95      


Leu Met Leu Leu Arg Leu Thr Glu Pro Ala Asp Thr Ile Thr Asp Ala 
            100                 105                 110         


Val Lys Val Val Glu Leu Pro Thr Gln Glu Pro Glu Val Gly Ser Thr 
        115                 120                 125             


Cys Leu Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Asn Phe Ser Phe 
    130                 135                 140                 


Pro Asp Asp Leu Gln Cys Val Asp Leu Lys Ile Leu Pro Asn Asp Glu 
145                 150                 155                 160 


Cys Lys Lys Val His Val Gln Lys Val Thr Asp Phe Met Leu Cys Val 
                165                 170                 175     


Gly His Leu Glu Gly Gly Lys Asp Thr Cys Val Gly Asp Ser Gly Gly 
            180                 185                 190         


Pro Leu Met Cys Asp Gly Val Leu Gln Gly Val Thr Ser Trp Gly Tyr 
        195                 200                 205             


Val Pro Cys Gly Thr Pro Asn Lys Pro Ser Val Ala Val Arg Val Leu 
    210                 215                 220                 


Ser Tyr Val Lys Trp Ile Glu Asp Thr Ile Ala Glu Asn Ser 
225                 230                 235             


