                         SEQUENCE LISTING

<110>  California Institute of Technology
 
<120>  HEME PROTEIN CATALYSTS FOR CARBON-BORON BOND FORMATION IN VITRO 
       AND IN VIVO

<130>  086544-020820PC-1075556

<140>  PCT/US18/21381
<141>  2018-03-07

<150>  US 62/467,909
<151>  2017-03-07

<150>  US 62/535,411
<151>  2017-07-21

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  124
<212>  PRT
<213>  Rhodothermus marinus

<400>  1

Thr Glu Ser Gly Thr Ala Ala Gln Asp Pro Glu Ala Leu Ala Ala Glu 
1               5                   10                  15      


Ile Gly Pro Val Lys Gln Val Ser Leu Gly Glu Gln Ile Asp Ala Ala 
            20                  25                  30          


Leu Ala Gln Gln Gly Glu Gln Leu Phe Asn Thr Tyr Cys Thr Ala Cys 
        35                  40                  45              


His Arg Leu Asp Glu Arg Phe Ile Gly Pro Ala Leu Arg Asp Val Thr 
    50                  55                  60                  


Lys Arg Arg Gly Pro Val Tyr Ile Met Asn Val Met Leu Asn Pro Asn 
65                  70                  75                  80  


Gly Met Ile Gln Arg His Pro Val Met Lys Gln Leu Val Gln Glu Tyr 
                85                  90                  95      


Gly Thr Met Met Thr Asp Met Ala Leu Ser Glu Glu Gln Ala Arg Ala 
            100                 105                 110         


Ile Leu Glu Tyr Leu Arg Gln Val Ala Glu Asn Gln 
        115                 120                 


<210>  2
<211>  104
<212>  PRT
<213>  Equus caballus

<400>  2

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Val Gln Lys Cys Ala Gln 
1               5                   10                  15      


Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
            20                  25                  30          


His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Phe Thr Tyr 
        35                  40                  45              


Thr Asp Ala Asn Lys Asn Lys Gly Ile Thr Trp Lys Glu Glu Thr Leu 
    50                  55                  60                  


Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
65                  70                  75                  80  


Ile Phe Ala Gly Ile Lys Lys Lys Thr Glu Arg Glu Asp Leu Ile Ala 
                85                  90                  95      


Tyr Leu Lys Lys Ala Thr Asn Glu 
            100                 


<210>  3
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Asp Val Glu Lys Gly Lys Lys Ile Phe Ile Met Lys Cys Ser Gln 
1               5                   10                  15      


Cys His Thr Val Glu Lys Gly Gly Lys His Lys Thr Gly Pro Asn Leu 
            20                  25                  30          


His Gly Leu Phe Gly Arg Lys Thr Gly Gln Ala Pro Gly Tyr Ser Tyr 
        35                  40                  45              


Thr Ala Ala Asn Lys Asn Lys Gly Ile Ile Trp Gly Glu Asp Thr Leu 
    50                  55                  60                  


Met Glu Tyr Leu Glu Asn Pro Lys Lys Tyr Ile Pro Gly Thr Lys Met 
65                  70                  75                  80  


Ile Phe Val Gly Ile Lys Lys Lys Glu Glu Arg Ala Asp Leu Ile Ala 
                85                  90                  95      


Tyr Leu Lys Lys Ala Thr Asn Glu 
            100                 


<210>  4
<211>  106
<212>  PRT
<213>  Rhodopila globiformis

<400>  4

Gly Ser Ala Pro Pro Gly Asp Pro Val Glu Gly Lys His Leu Phe His 
1               5                   10                  15      


Thr Ile Cys Ile Leu Cys His Thr Asp Ile Lys Gly Arg Asn Lys Val 
            20                  25                  30          


Gly Pro Ser Leu Tyr Gly Val Val Gly Arg His Ser Gly Ile Glu Pro 
        35                  40                  45              


Gly Tyr Asn Tyr Ser Glu Ala Asn Ile Lys Ser Gly Ile Val Trp Thr 
    50                  55                  60                  


Pro Asp Val Leu Phe Lys Tyr Ile Glu His Pro Gln Lys Ile Val Pro 
65                  70                  75                  80  


Gly Thr Lys Met Gly Tyr Pro Gly Gln Pro Asp Pro Gln Lys Arg Ala 
                85                  90                  95      


Asp Ile Ile Ala Tyr Leu Glu Thr Leu Lys 
            100                 105     


<210>  5
<211>  80
<212>  PRT
<213>  Hydrogenobacter thermophilus

<400>  5

Asn Glu Gln Leu Ala Lys Gln Lys Gly Cys Met Ala Cys His Asp Leu 
1               5                   10                  15      


Lys Ala Lys Lys Val Gly Pro Ala Tyr Ala Asp Val Ala Lys Lys Tyr 
            20                  25                  30          


Ala Gly Arg Lys Asp Ala Val Asp Tyr Leu Ala Gly Lys Ile Lys Lys 
        35                  40                  45              


Gly Gly Ser Gly Val Trp Gly Ser Val Pro Met Pro Pro Gln Asn Val 
    50                  55                  60                  


Thr Asp Ala Glu Ala Lys Gln Leu Ala Gln Trp Ile Leu Ser Ile Lys 
65                  70                  75                  80  


<210>  6
<211>  414
<212>  PRT
<213>  Pseudomonas putida

<400>  6

Thr Thr Glu Thr Ile Gln Ser Asn Ala Asn Leu Ala Pro Leu Pro Pro 
1               5                   10                  15      


His Val Pro Glu His Leu Val Phe Asp Phe Asp Met Tyr Asn Pro Ser 
            20                  25                  30          


Asn Leu Ser Ala Gly Val Gln Glu Ala Trp Ala Val Leu Gln Glu Ser 
        35                  40                  45              


Asn Val Pro Asp Leu Val Trp Thr Arg Cys Asn Gly Gly His Trp Ile 
    50                  55                  60                  


Ala Thr Arg Gly Gln Leu Ile Arg Glu Ala Tyr Glu Asp Tyr Arg His 
65                  70                  75                  80  


Phe Ser Ser Glu Cys Pro Phe Ile Pro Arg Glu Ala Gly Glu Ala Tyr 
                85                  90                  95      


Asp Phe Ile Pro Thr Ser Met Asp Pro Pro Glu Gln Arg Gln Phe Arg 
            100                 105                 110         


Ala Leu Ala Asn Gln Val Val Gly Met Pro Val Val Asp Lys Leu Glu 
        115                 120                 125             


Asn Arg Ile Gln Glu Leu Ala Cys Ser Leu Ile Glu Ser Leu Arg Pro 
    130                 135                 140                 


Gln Gly Gln Cys Asn Phe Thr Glu Asp Tyr Ala Glu Pro Phe Pro Ile 
145                 150                 155                 160 


Arg Ile Phe Met Leu Leu Ala Gly Leu Pro Glu Glu Asp Ile Pro His 
                165                 170                 175     


Leu Lys Tyr Leu Thr Asp Gln Met Thr Arg Pro Asp Gly Ser Met Thr 
            180                 185                 190         


Phe Ala Glu Ala Lys Glu Ala Leu Tyr Asp Tyr Leu Ile Pro Ile Ile 
        195                 200                 205             


Glu Gln Arg Arg Gln Lys Pro Gly Thr Asp Ala Ile Ser Ile Val Ala 
    210                 215                 220                 


Asn Gly Gln Val Asn Gly Arg Pro Ile Thr Ser Asp Glu Ala Lys Arg 
225                 230                 235                 240 


Met Cys Gly Leu Leu Leu Val Gly Gly Leu Asp Thr Val Val Asn Phe 
                245                 250                 255     


Leu Ser Phe Ser Met Glu Phe Leu Ala Lys Ser Pro Glu His Arg Gln 
            260                 265                 270         


Glu Leu Ile Glu Arg Pro Glu Arg Ile Pro Ala Ala Cys Glu Glu Leu 
        275                 280                 285             


Leu Arg Arg Phe Ser Leu Val Ala Asp Gly Arg Ile Leu Thr Ser Asp 
    290                 295                 300                 


Tyr Glu Phe His Gly Val Gln Leu Lys Lys Gly Asp Gln Ile Leu Leu 
305                 310                 315                 320 


Pro Gln Met Leu Ser Gly Leu Asp Glu Arg Glu Asn Ala Cys Pro Met 
                325                 330                 335     


His Val Asp Phe Ser Arg Gln Lys Val Ser His Thr Thr Phe Gly His 
            340                 345                 350         


Gly Ser His Leu Cys Leu Gly Gln His Leu Ala Arg Arg Glu Ile Ile 
        355                 360                 365             


Val Thr Leu Lys Glu Trp Leu Thr Arg Ile Pro Asp Phe Ser Ile Ala 
    370                 375                 380                 


Pro Gly Ala Gln Ile Gln His Lys Ser Gly Ile Val Ser Gly Val Gln 
385                 390                 395                 400 


Ala Leu Pro Leu Val Trp Asp Pro Ala Thr Thr Lys Ala Val 
                405                 410                 


<210>  7
<211>  471
<212>  PRT
<213>  Bacillus megaterium

<400>  7

Thr Ile Lys Glu Met Pro Gln Pro Lys Thr Phe Gly Glu Leu Lys Asn 
1               5                   10                  15      


Leu Pro Leu Leu Asn Thr Asp Lys Pro Val Gln Ala Leu Met Lys Ile 
            20                  25                  30          


Ala Asp Glu Leu Gly Glu Ile Phe Lys Phe Glu Ala Pro Gly Arg Val 
        35                  40                  45              


Thr Arg Tyr Leu Ser Ser Gln Arg Leu Ile Lys Glu Ala Cys Asp Glu 
    50                  55                  60                  


Ser Arg Phe Asp Lys Asn Leu Ser Gln Ala Leu Lys Phe Val Arg Asp 
65                  70                  75                  80  


Phe Ala Gly Asp Gly Leu Phe Thr Ser Trp Thr His Glu Lys Asn Trp 
                85                  90                  95      


Lys Lys Ala His Asn Ile Leu Leu Pro Ser Phe Ser Gln Gln Ala Met 
            100                 105                 110         


Lys Gly Tyr His Ala Met Met Val Asp Ile Ala Val Gln Leu Val Gln 
        115                 120                 125             


Lys Trp Glu Arg Leu Asn Ala Asp Glu His Ile Glu Val Pro Glu Asp 
    130                 135                 140                 


Met Thr Arg Leu Thr Leu Asp Thr Ile Gly Leu Cys Gly Phe Asn Tyr 
145                 150                 155                 160 


Arg Phe Asn Ser Phe Tyr Arg Asp Gln Pro His Pro Phe Ile Thr Ser 
                165                 170                 175     


Met Val Arg Ala Leu Asp Glu Ala Met Asn Lys Leu Gln Arg Ala Asn 
            180                 185                 190         


Pro Asp Asp Pro Ala Tyr Asp Glu Asn Lys Arg Gln Phe Gln Glu Asp 
        195                 200                 205             


Ile Lys Val Met Asn Asp Leu Val Asp Lys Ile Ile Ala Asp Arg Lys 
    210                 215                 220                 


Ala Ser Gly Glu Gln Ser Asp Asp Leu Leu Thr His Met Leu Asn Gly 
225                 230                 235                 240 


Lys Asp Pro Glu Thr Gly Glu Pro Leu Asp Asp Glu Asn Ile Arg Tyr 
                245                 250                 255     


Gln Ile Ile Thr Phe Leu Ile Ala Gly His Glu Thr Thr Ser Gly Leu 
            260                 265                 270         


Leu Ser Phe Ala Leu Tyr Phe Leu Val Lys Asn Pro His Val Leu Gln 
        275                 280                 285             


Lys Ala Ala Glu Glu Ala Ala Arg Val Leu Val Asp Pro Val Pro Ser 
    290                 295                 300                 


Tyr Lys Gln Val Lys Gln Leu Lys Tyr Val Gly Met Val Leu Asn Glu 
305                 310                 315                 320 


Ala Leu Arg Leu Trp Pro Thr Ala Pro Ala Phe Ser Leu Tyr Ala Lys 
                325                 330                 335     


Glu Asp Thr Val Leu Gly Gly Glu Tyr Pro Leu Glu Lys Gly Asp Glu 
            340                 345                 350         


Leu Met Val Leu Ile Pro Gln Leu His Arg Asp Lys Thr Ile Trp Gly 
        355                 360                 365             


Asp Asp Val Glu Glu Phe Arg Pro Glu Arg Phe Glu Asn Pro Ser Ala 
    370                 375                 380                 


Ile Pro Gln His Ala Phe Lys Pro Phe Gly Asn Gly Gln Arg Ala Cys 
385                 390                 395                 400 


Ile Gly Gln Gln Phe Ala Leu His Glu Ala Thr Leu Val Leu Gly Met 
                405                 410                 415     


Met Leu Lys His Phe Asp Phe Glu Asp His Thr Asn Tyr Glu Leu Asp 
            420                 425                 430         


Ile Lys Glu Thr Leu Thr Leu Lys Pro Glu Gly Phe Val Val Lys Ala 
        435                 440                 445             


Lys Ser Lys Lys Ile Pro Leu Gly Gly Ile Pro Ser Pro Ser Thr Glu 
    450                 455                 460                 


Gln Ser Ala Lys Lys Val Arg 
465                 470     


<210>  8
<211>  133
<212>  PRT
<213>  Methylacidiphilum infernorum

<400>  8

Met Ile Asp Gln Lys Glu Lys Glu Leu Ile Lys Glu Ser Trp Lys Arg 
1               5                   10                  15      


Ile Glu Pro Asn Lys Asn Glu Ile Gly Leu Leu Phe Tyr Ala Asn Leu 
            20                  25                  30          


Phe Lys Glu Glu Pro Thr Val Ser Val Leu Phe Gln Asn Pro Ile Ser 
        35                  40                  45              


Ser Gln Ser Arg Lys Leu Met Gln Val Leu Gly Ile Leu Val Gln Gly 
    50                  55                  60                  


Ile Asp Asn Leu Glu Gly Leu Ile Pro Thr Leu Gln Asp Leu Gly Arg 
65                  70                  75                  80  


Arg His Lys Gln Tyr Gly Val Val Asp Ser His Tyr Pro Leu Val Gly 
                85                  90                  95      


Asp Cys Leu Leu Lys Ser Ile Gln Glu Tyr Leu Gly Gln Gly Phe Thr 
            100                 105                 110         


Glu Glu Ala Lys Ala Ala Trp Thr Lys Val Tyr Gly Ile Ala Ala Gln 
        115                 120                 125             


Val Met Thr Ala Glu 
    130             


<210>  9
<211>  140
<212>  PRT
<213>  Campylobacter jejuni

<400>  9

Met Thr Lys Glu Gln Ile Gln Ile Ile Lys Asp Cys Val Pro Ile Leu 
1               5                   10                  15      


Gln Lys Asn Gly Glu Asp Leu Thr Asn Glu Phe Tyr Lys Ile Met Phe 
            20                  25                  30          


Asn Asp Tyr Pro Glu Val Lys Pro Met Phe Asn Met Glu Lys Gln Ile 
        35                  40                  45              


Ser Gly Glu Gln Pro Lys Ala Leu Ala Met Ala Ile Leu Met Ala Ala 
    50                  55                  60                  


Lys Asn Ile Glu Asn Leu Glu Asn Met Arg Ser Phe Val Asp Lys Val 
65                  70                  75                  80  


Ala Ile Thr His Val Asn Leu Gly Val Lys Glu Glu His Tyr Pro Ile 
                85                  90                  95      


Val Gly Ala Cys Leu Leu Lys Ala Ile Lys Asn Leu Leu Asn Pro Asp 
            100                 105                 110         


Glu Ala Thr Leu Lys Ala Trp Glu Val Ala Tyr Gly Lys Ile Ala Lys 
        115                 120                 125             


Phe Tyr Ile Asp Ile Glu Lys Lys Leu Tyr Asp Lys 
    130                 135                 140 


<210>  10
<211>  146
<212>  PRT
<213>  Vitreoscilla stercoraria

<400>  10

Met Leu Asp Gln Gln Thr Ile Asn Ile Ile Lys Ala Thr Val Pro Val 
1               5                   10                  15      


Leu Lys Glu His Gly Val Thr Ile Thr Thr Thr Phe Tyr Lys Asn Leu 
            20                  25                  30          


Phe Ala Lys His Pro Glu Val Arg Pro Leu Phe Asp Met Gly Arg Gln 
        35                  40                  45              


Glu Ser Leu Glu Gln Pro Lys Ala Leu Ala Met Thr Val Leu Ala Ala 
    50                  55                  60                  


Ala Gln Asn Ile Glu Asn Leu Pro Ala Ile Leu Pro Ala Val Lys Lys 
65                  70                  75                  80  


Ile Ala Val Lys His Cys Gln Ala Gly Val Ala Ala Ala His Tyr Pro 
                85                  90                  95      


Ile Val Gly Gln Glu Leu Leu Gly Ala Ile Lys Glu Val Leu Gly Asp 
            100                 105                 110         


Ala Ala Thr Asp Asp Ile Leu Asp Ala Trp Gly Lys Ala Tyr Gly Val 
        115                 120                 125             


Ile Ala Asp Val Phe Ile Gln Val Glu Ala Asp Leu Tyr Ala Gln Ala 
    130                 135                 140                 


Val Glu 
145     


<210>  11
<211>  150
<212>  PRT
<213>  Mus musculus

<400>  11

Met Glu Arg Pro Glu Ser Glu Leu Ile Arg Gln Ser Trp Arg Val Val 
1               5                   10                  15      


Ser Arg Ser Pro Leu Glu His Gly Thr Val Leu Phe Ala Arg Leu Phe 
            20                  25                  30          


Ala Leu Glu Pro Ser Leu Leu Pro Leu Phe Gln Tyr Asn Gly Arg Gln 
        35                  40                  45              


Phe Ser Ser Pro Glu Asp Cys Leu Ser Ser Pro Glu Phe Leu Asp His 
    50                  55                  60                  


Ile Arg Lys Val Met Leu Val Ile Asp Ala Ala Val Thr Asn Val Glu 
65                  70                  75                  80  


Asp Leu Ser Ser Leu Glu Glu Tyr Leu Thr Ser Leu Gly Arg Lys His 
                85                  90                  95      


Arg Ala Val Gly Val Arg Leu Ser Ser Phe Ser Thr Val Gly Glu Ser 
            100                 105                 110         


Leu Leu Tyr Met Leu Glu Lys Cys Leu Gly Pro Asp Phe Thr Pro Ala 
        115                 120                 125             


Thr Arg Thr Ala Trp Ser Arg Leu Tyr Gly Ala Val Val Gln Ala Met 
    130                 135                 140                 


Ser Arg Gly Trp Asp Gly 
145                 150 


<210>  12
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Arg Pro Glu Pro Glu Leu Ile Arg Gln Ser Trp Arg Ala Val 
1               5                   10                  15      


Ser Arg Ser Pro Leu Glu His Gly Thr Val Leu Phe Ala Arg Leu Phe 
            20                  25                  30          


Ala Leu Glu Pro Asp Leu Leu Pro Leu Phe Gln Tyr Asn Cys Arg Gln 
        35                  40                  45              


Phe Ser Ser Pro Glu Asp Cys Leu Ser Ser Pro Glu Phe Leu Asp His 
    50                  55                  60                  


Ile Arg Lys Val Met Leu Val Ile Asp Ala Ala Val Thr Asn Val Glu 
65                  70                  75                  80  


Asp Leu Ser Ser Leu Glu Glu Tyr Leu Ala Ser Leu Gly Arg Lys His 
                85                  90                  95      


Arg Ala Val Gly Val Lys Leu Ser Ser Phe Ser Thr Val Gly Glu Ser 
            100                 105                 110         


Leu Leu Tyr Met Leu Glu Lys Cys Leu Gly Pro Ala Phe Thr Pro Ala 
        115                 120                 125             


Thr Arg Ala Ala Trp Ser Gln Leu Tyr Gly Ala Val Val Gln Ala Met 
    130                 135                 140                 


Ser Arg Gly Trp Asp Gly Glu 
145                 150     


<210>  13
<211>  150
<212>  PRT
<213>  Physeter catodon

<400>  13

Met Val Leu Ser Glu Gly Glu Trp Gln Leu Val Leu His Val Trp Ala 
1               5                   10                  15      


Lys Val Glu Ala Asp Val Ala Gly His Gly Gln Asp Ile Leu Ile Arg 
            20                  25                  30          


Leu Phe Lys Ser His Pro Glu Thr Leu Glu Lys Phe Asp Arg Phe Lys 
        35                  40                  45              


His Leu Lys Thr Glu Ala Glu Met Lys Ala Ser Glu Asp Leu Lys Lys 
    50                  55                  60                  


His Gly Val Thr Val Leu Thr Ala Leu Gly Ala Ile Leu Lys Lys Lys 
65                  70                  75                  80  


Gly His His Glu Ala Glu Leu Lys Pro Leu Ala Gln Ser His Ala Thr 
                85                  90                  95      


Lys His Lys Ile Pro Ile Lys Tyr Leu Glu Phe Ile Ser Glu Ala Ile 
            100                 105                 110         


Ile His Val Leu His Ser Arg His Pro Gly Asp Phe Gly Ala Asp Ala 
        115                 120                 125             


Gln Gly Ala Met Asn Lys Ala Leu Glu Leu Phe Arg Lys Asp Ile Ala 
    130                 135                 140                 


Ala Lys Tyr Lys Glu Leu 
145                 150 


<210>  14
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Lys Val Pro Gly Glu Met Glu Ile Glu Arg Arg Glu Arg Ser 
1               5                   10                  15      


Glu Glu Leu Ser Glu Ala Glu Arg Lys Ala Val Gln Ala Met Trp Ala 
            20                  25                  30          


Arg Leu Tyr Ala Asn Cys Glu Asp Val Gly Val Ala Ile Leu Val Arg 
        35                  40                  45              


Phe Phe Val Asn Phe Pro Ser Ala Lys Gln Tyr Phe Ser Gln Phe Lys 
    50                  55                  60                  


His Met Glu Asp Pro Leu Glu Met Glu Arg Ser Pro Gln Leu Arg Lys 
65                  70                  75                  80  


His Ala Cys Arg Val Met Gly Ala Leu Asn Thr Val Val Glu Asn Leu 
                85                  90                  95      


His Asp Pro Asp Lys Val Ser Ser Val Leu Ala Leu Val Gly Lys Ala 
            100                 105                 110         


His Ala Leu Lys His Lys Val Glu Pro Val Tyr Phe Lys Ile Leu Ser 
        115                 120                 125             


Gly Val Ile Leu Glu Val Val Ala Glu Glu Phe Ala Ser Asp Phe Pro 
    130                 135                 140                 


Pro Glu Thr Gln Arg Ala Trp Ala Lys Leu Arg Gly Leu Ile Tyr Ser 
145                 150                 155                 160 


His Val Thr Ala Ala Tyr Lys Glu Val Gly Trp Val Gln Gln Val Pro 
                165                 170                 175     


Asn Ala Thr Thr Pro Pro Ala Thr Leu Pro Ser Ser Gly Pro 
            180                 185                 190 


<210>  15
<211>  338
<212>  PRT
<213>  Ascaris suum

<400>  15

Met Arg Ser Leu Leu Leu Leu Ser Ile Val Phe Phe Val Val Thr Val 
1               5                   10                  15      


Ser Ala Asn Lys Thr Arg Glu Leu Cys Met Lys Ser Leu Glu His Ala 
            20                  25                  30          


Lys Val Asp Thr Ser Asn Glu Ala Arg Gln Asp Gly Ile Asp Leu Tyr 
        35                  40                  45              


Lys His Met Phe Glu Asn Tyr Pro Pro Leu Arg Lys Tyr Phe Lys Asn 
    50                  55                  60                  


Arg Glu Glu Tyr Thr Ala Glu Asp Val Gln Asn Asp Pro Phe Phe Ala 
65                  70                  75                  80  


Lys Gln Gly Gln Lys Ile Leu Leu Ala Cys His Val Leu Cys Ala Thr 
                85                  90                  95      


Tyr Asp Asp Arg Glu Thr Phe Asn Ala Tyr Thr Arg Glu Leu Leu Asp 
            100                 105                 110         


Arg His Ala Arg Asp His Val His Met Pro Pro Glu Val Trp Thr Asp 
        115                 120                 125             


Phe Trp Lys Leu Phe Glu Glu Tyr Leu Gly Lys Lys Thr Thr Leu Asp 
    130                 135                 140                 


Glu Pro Thr Lys Gln Ala Trp His Glu Ile Gly Arg Glu Phe Ala Lys 
145                 150                 155                 160 


Glu Ile Asn Lys His Gly Arg His Ala Val Arg His Gln Cys Met Arg 
                165                 170                 175     


Ser Leu Gln His Ile Asp Ile Gly His Ser Glu Thr Ala Lys Gln Asn 
            180                 185                 190         


Gly Ile Asp Leu Tyr Lys His Met Phe Glu Asn Tyr Pro Ser Met Arg 
        195                 200                 205             


Glu Ala Phe Lys Asp Arg Glu Asn Tyr Thr Ala Glu Asp Val Gln Lys 
    210                 215                 220                 


Asp Pro Phe Phe Val Lys Gln Gly Gln Arg Ile Leu Leu Ala Cys His 
225                 230                 235                 240 


Leu Leu Cys Ala Ser Tyr Asp Asp Glu Glu Thr Phe His Met Tyr Val 
                245                 250                 255     


His Glu Leu Met Glu Arg His Glu Arg Leu Gly Val Gln Leu Pro Asp 
            260                 265                 270         


Gln His Trp Thr Asp Phe Trp Lys Leu Phe Glu Glu Phe Leu Glu Lys 
        275                 280                 285             


Lys Ser His Leu Cys Glu His Thr Lys His Ala Trp Ala Val Ile Gly 
    290                 295                 300                 


Lys Glu Phe Ala Tyr Glu Ala Thr Arg His Gly Lys Glu His His Glu 
305                 310                 315                 320 


His Lys Glu Glu His Lys Glu Glu His Lys Glu Glu His Lys Glu Glu 
                325                 330                 335     


Gln His 
        


<210>  16
<211>  132
<212>  PRT
<213>  Bacillus subtilis

<400>  16

Met Gly Gln Ser Phe Asn Ala Pro Tyr Glu Ala Ile Gly Glu Glu Leu 
1               5                   10                  15      


Leu Ser Gln Leu Val Asp Thr Phe Tyr Glu Arg Val Ala Ser His Pro 
            20                  25                  30          


Leu Leu Lys Pro Ile Phe Pro Ser Asp Leu Thr Glu Thr Ala Arg Lys 
        35                  40                  45              


Gln Lys Gln Phe Leu Thr Gln Tyr Leu Gly Gly Pro Pro Leu Tyr Thr 
    50                  55                  60                  


Glu Glu His Gly His Pro Met Leu Arg Ala Arg His Leu Pro Phe Pro 
65                  70                  75                  80  


Ile Thr Asn Glu Arg Ala Asp Ala Trp Leu Ser Cys Met Lys Asp Ala 
                85                  90                  95      


Met Asp His Val Gly Leu Glu Gly Glu Ile Arg Glu Phe Leu Phe Gly 
            100                 105                 110         


Arg Leu Glu Leu Thr Ala Arg His Met Val Asn Gln Thr Glu Ala Glu 
        115                 120                 125             


Asp Arg Ser Ser 
    130         


<210>  17
<211>  195
<212>  PRT
<213>  Methanosarcina acetivorans

<400>  17

Met Ser Val Glu Lys Ile Pro Gly Tyr Thr Tyr Gly Glu Thr Glu Asn 
1               5                   10                  15      


Arg Ala Pro Phe Asn Leu Glu Asp Leu Lys Leu Leu Lys Glu Ala Val 
            20                  25                  30          


Met Phe Thr Ala Glu Asp Glu Glu Tyr Ile Gln Lys Ala Gly Glu Val 
        35                  40                  45              


Leu Glu Asp Gln Val Glu Glu Ile Leu Asp Thr Trp Tyr Gly Phe Val 
    50                  55                  60                  


Gly Ser His Pro His Leu Leu Tyr Tyr Phe Thr Ser Pro Asp Gly Thr 
65                  70                  75                  80  


Pro Asn Glu Lys Tyr Leu Ala Ala Val Arg Lys Arg Phe Ser Arg Trp 
                85                  90                  95      


Ile Leu Asp Thr Cys Asn Arg Ser Tyr Asp Gln Ala Trp Leu Asp Tyr 
            100                 105                 110         


Gln Tyr Glu Ile Gly Leu Arg His His Arg Thr Lys Lys Asn Gln Thr 
        115                 120                 125             


Asp Asn Val Glu Ser Val Pro Asn Ile Gly Tyr Arg Tyr Leu Val Ala 
    130                 135                 140                 


Phe Ile Tyr Pro Ile Thr Ala Thr Met Lys Pro Phe Leu Ala Arg Lys 
145                 150                 155                 160 


Gly His Thr Pro Glu Glu Val Glu Lys Met Tyr Gln Ala Trp Phe Lys 
                165                 170                 175     


Ala Thr Thr Leu Gln Val Ala Leu Trp Ser Tyr Pro Tyr Val Lys Tyr 
            180                 185                 190         


Gly Asp Phe 
        195 


<210>  18
<211>  195
<212>  PRT
<213>  Aeropyrum pernix

<400>  18

Met Thr Pro Ser Asp Ile Pro Gly Tyr Asp Tyr Gly Arg Val Glu Lys 
1               5                   10                  15      


Ser Pro Ile Thr Asp Leu Glu Phe Asp Leu Leu Lys Lys Thr Val Met 
            20                  25                  30          


Leu Gly Glu Lys Asp Val Met Tyr Leu Lys Lys Ala Cys Asp Val Leu 
        35                  40                  45              


Lys Asp Gln Val Asp Glu Ile Leu Asp Leu Trp Tyr Gly Trp Val Ala 
    50                  55                  60                  


Ser Asn Glu His Leu Ile Tyr Tyr Phe Ser Asn Pro Asp Thr Gly Glu 
65                  70                  75                  80  


Pro Ile Lys Glu Tyr Leu Glu Arg Val Arg Ala Arg Phe Gly Ala Trp 
                85                  90                  95      


Ile Leu Asp Thr Thr Cys Arg Asp Tyr Asn Arg Glu Trp Leu Asp Tyr 
            100                 105                 110         


Gln Tyr Glu Val Gly Leu Arg His His Arg Ser Lys Lys Gly Val Thr 
        115                 120                 125             


Asp Gly Val Arg Thr Val Pro His Ile Pro Leu Arg Tyr Leu Ile Ala 
    130                 135                 140                 


Phe Ile Tyr Pro Ile Thr Ala Thr Ile Lys Pro Phe Leu Ala Lys Lys 
145                 150                 155                 160 


Gly Gly Ser Pro Glu Asp Ile Glu Gly Met Tyr Asn Ala Trp Phe Lys 
                165                 170                 175     


Ser Val Val Leu Gln Val Ala Ile Trp Ser His Pro Tyr Thr Lys Glu 
            180                 185                 190         


Asn Asp Trp 
        195 


<210>  19
<211>  192
<212>  PRT
<213>  Pyrobaculum ferrireducens

<400>  19

Met Arg Glu Ile Pro Gly Tyr Glu Phe Gly Lys Val Pro Asp Ala Pro 
1               5                   10                  15      


Ile Ser Asp Glu Glu Phe Glu Leu Leu Lys Lys Ser Val Met Trp Thr 
            20                  25                  30          


Glu Glu Asp Glu Lys Tyr Arg Lys Leu Ala Cys Glu Val Leu Lys Gly 
        35                  40                  45              


Gln Val Glu Gln Ile Leu Asp Leu Trp Tyr Gly Trp Val Gly Ser Asn 
    50                  55                  60                  


Pro His Leu Val Tyr Tyr Phe Gly Asp Arg Ser Gly Arg Pro Ile Pro 
65                  70                  75                  80  


Gln Tyr Leu Glu Ala Val Arg Lys Arg Phe Gly Gln Trp Ile Leu Asp 
                85                  90                  95      


Thr Val Cys Arg Ser Tyr Asp Arg Gln Trp Leu Asn Tyr Val Tyr Glu 
            100                 105                 110         


Ile Gly Leu Arg His His Arg Thr Lys Lys Gly Lys Thr Asp Gly Val 
        115                 120                 125             


Glu Thr Val Glu His Ile Pro Leu Arg Tyr Met Val Ala Phe Ile Ala 
    130                 135                 140                 


Pro Ile Gly Leu Thr Ile Lys Pro Phe Leu Glu Lys Gly Gly His Pro 
145                 150                 155                 160 


Pro Asp Val Val Glu Lys Met Trp Ala Ala Trp Ile Lys Ser Val Val 
                165                 170                 175     


Leu Gln Val Ala Ile Trp Ser His Pro Tyr Ala Lys Pro Gly Glu Trp 
            180                 185                 190         


<210>  20
<211>  400
<212>  PRT
<213>  Cupriavidus necator

<400>  20

Met Leu Thr Gln Lys Thr Lys Asp Ile Val Lys Ala Thr Ala Pro Val 
1               5                   10                  15      


Leu Ala Glu His Gly Tyr Asp Ile Ile Lys Cys Phe Tyr Gln Arg Met 
            20                  25                  30          


Phe Glu Ala His Pro Glu Leu Lys Asn Val Phe Asn Met Ala His Gln 
        35                  40                  45              


Glu Gln Gly Gln Gln Gln Gln Ala Leu Ala Arg Ala Val Tyr Ala Tyr 
    50                  55                  60                  


Ala Glu Asn Ile Glu Asp Pro Asn Ser Leu Met Ala Val Leu Lys Asn 
65                  70                  75                  80  


Ile Ala Asn Lys His Ala Ser Leu Gly Val Lys Pro Glu Gln Tyr Pro 
                85                  90                  95      


Ile Val Gly Glu His Leu Leu Ala Ala Ile Lys Glu Val Leu Gly Asn 
            100                 105                 110         


Ala Ala Thr Asp Asp Ile Ile Ser Ala Trp Ala Gln Ala Tyr Gly Asn 
        115                 120                 125             


Leu Ala Asp Val Leu Met Gly Met Glu Ser Glu Leu Tyr Glu Arg Ser 
    130                 135                 140                 


Ala Glu Gln Pro Gly Gly Trp Lys Gly Trp Arg Thr Phe Val Ile Arg 
145                 150                 155                 160 


Glu Lys Arg Pro Glu Ser Asp Val Ile Thr Ser Phe Ile Leu Glu Pro 
                165                 170                 175     


Ala Asp Gly Gly Pro Val Val Asn Phe Glu Pro Gly Gln Tyr Thr Ser 
            180                 185                 190         


Val Ala Ile Asp Val Pro Ala Leu Gly Leu Gln Gln Ile Arg Gln Tyr 
        195                 200                 205             


Ser Leu Ser Asp Met Pro Asn Gly Arg Ser Tyr Arg Ile Ser Val Lys 
    210                 215                 220                 


Arg Glu Gly Gly Gly Pro Gln Pro Pro Gly Tyr Val Ser Asn Leu Leu 
225                 230                 235                 240 


His Asp His Val Asn Val Gly Asp Gln Val Lys Leu Ala Ala Pro Tyr 
                245                 250                 255     


Gly Ser Phe His Ile Asp Val Asp Ala Lys Thr Pro Ile Val Leu Ile 
            260                 265                 270         


Ser Gly Gly Val Gly Leu Thr Pro Met Val Ser Met Leu Lys Val Ala 
        275                 280                 285             


Leu Gln Ala Pro Pro Arg Gln Val Val Phe Val His Gly Ala Arg Asn 
    290                 295                 300                 


Ser Ala Val His Ala Met Arg Asp Arg Leu Arg Glu Ala Ala Lys Thr 
305                 310                 315                 320 


Tyr Glu Asn Leu Asp Leu Phe Val Phe Tyr Asp Gln Pro Leu Pro Glu 
                325                 330                 335     


Asp Val Gln Gly Arg Asp Tyr Asp Tyr Pro Gly Leu Val Asp Val Lys 
            340                 345                 350         


Gln Ile Glu Lys Ser Ile Leu Leu Pro Asp Ala Asp Tyr Tyr Ile Cys 
        355                 360                 365             


Gly Pro Ile Pro Phe Met Arg Met Gln His Asp Ala Leu Lys Asn Leu 
    370                 375                 380                 


Gly Ile His Glu Ala Arg Ile His Tyr Glu Val Phe Gly Pro Asp Leu 
385                 390                 395                 400 


<210>  21
<211>  145
<212>  PRT
<213>  Rhodothermus marinus

<400>  21

Met Ala Pro Thr Leu Ser Glu Gln Thr Arg Gln Leu Val Arg Ala Ser 
1               5                   10                  15      


Val Pro Ala Leu Gln Lys His Ser Val Ala Ile Ser Ala Thr Met Tyr 
            20                  25                  30          


Arg Leu Leu Phe Glu Arg Tyr Pro Glu Thr Arg Ser Leu Phe Glu Leu 
        35                  40                  45              


Pro Glu Arg Gln Ile His Lys Leu Ala Ser Ala Leu Leu Ala Tyr Ala 
    50                  55                  60                  


Arg Ser Ile Asp Asn Pro Ser Ala Leu Gln Ala Ala Ile Arg Arg Met 
65                  70                  75                  80  


Val Leu Ser His Ala Arg Ala Gly Val Gln Ala Val His Tyr Pro Leu 
                85                  90                  95      


Val Trp Glu Cys Leu Arg Asp Ala Ile Lys Glu Val Leu Gly Pro Asp 
            100                 105                 110         


Ala Thr Glu Thr Leu Leu Gln Ala Trp Lys Glu Ala Tyr Asp Phe Leu 
        115                 120                 125             


Ala His Leu Leu Ser Thr Lys Glu Ala Gln Val Tyr Ala Val Leu Ala 
    130                 135                 140                 


Glu 
145 


<210>  22
<211>  293
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  22

Thr Pro Leu Val His Val Ala Ser Val Glu Lys Gly Arg Ser Tyr Glu 
1               5                   10                  15      


Asp Phe Gln Lys Val Tyr Asn Ala Ile Ala Leu Lys Leu Arg Glu Asp 
            20                  25                  30          


Asp Glu Tyr Asp Asn Tyr Ile Gly Tyr Gly Pro Val Leu Val Arg Leu 
        35                  40                  45              


Ala Trp His Thr Ser Gly Thr Trp Asp Lys His Asp Asn Thr Gly Gly 
    50                  55                  60                  


Ser Tyr Gly Gly Thr Tyr Arg Phe Lys Lys Glu Phe Asn Asp Pro Ser 
65                  70                  75                  80  


Asn Ala Gly Leu Gln Asn Gly Phe Lys Phe Leu Glu Pro Ile His Lys 
                85                  90                  95      


Glu Phe Pro Trp Ile Ser Ser Gly Asp Leu Phe Ser Leu Gly Gly Val 
            100                 105                 110         


Thr Ala Val Gln Glu Met Gln Gly Pro Lys Ile Pro Trp Arg Cys Gly 
        115                 120                 125             


Arg Val Asp Thr Pro Glu Asp Thr Thr Pro Asp Asn Gly Arg Leu Pro 
    130                 135                 140                 


Asp Ala Asp Lys Asp Ala Asp Tyr Val Arg Thr Phe Phe Gln Arg Leu 
145                 150                 155                 160 


Asn Met Asn Asp Arg Glu Val Val Ala Leu Met Gly Ala His Ala Leu 
                165                 170                 175     


Gly Lys Thr His Leu Lys Asn Ser Gly Tyr Glu Gly Pro Trp Gly Ala 
            180                 185                 190         


Ala Asn Asn Val Phe Thr Asn Glu Phe Tyr Leu Asn Leu Leu Asn Glu 
        195                 200                 205             


Asp Trp Lys Leu Glu Lys Asn Asp Ala Asn Asn Glu Gln Trp Asp Ser 
    210                 215                 220                 


Lys Ser Gly Tyr Met Met Leu Pro Thr Asp Tyr Ser Leu Ile Gln Asp 
225                 230                 235                 240 


Pro Lys Tyr Leu Ser Ile Val Lys Glu Tyr Ala Asn Asp Gln Asp Lys 
                245                 250                 255     


Phe Phe Lys Asp Phe Ser Lys Ala Phe Glu Lys Leu Leu Glu Asn Gly 
            260                 265                 270         


Ile Thr Phe Pro Lys Asp Ala Pro Ser Pro Phe Ile Phe Lys Thr Leu 
        275                 280                 285             


Glu Glu Gln Gly Leu 
    290             


<210>  23
<211>  306
<212>  PRT
<213>  Armoracia rusticana

<400>  23

Gln Leu Thr Pro Thr Phe Tyr Asp Asn Ser Cys Pro Asn Val Ser Asn 
1               5                   10                  15      


Ile Val Arg Asp Thr Ile Val Asn Glu Leu Arg Ser Asp Pro Arg Ile 
            20                  25                  30          


Ala Ala Ser Ile Leu Arg Leu His Phe His Asp Cys Phe Val Asn Gly 
        35                  40                  45              


Cys Asp Ala Ser Ile Leu Leu Asp Asn Thr Thr Ser Phe Arg Thr Glu 
    50                  55                  60                  


Lys Asp Ala Phe Gly Asn Ala Asn Ser Ala Arg Gly Phe Pro Val Ile 
65                  70                  75                  80  


Asp Arg Met Lys Ala Ala Val Glu Ser Ala Cys Pro Arg Thr Val Ser 
                85                  90                  95      


Cys Ala Asp Leu Leu Thr Ile Ala Ala Gln Gln Ser Val Thr Leu Ala 
            100                 105                 110         


Gly Gly Pro Ser Trp Arg Val Pro Leu Gly Arg Arg Asp Ser Leu Gln 
        115                 120                 125             


Ala Phe Leu Asp Leu Ala Asn Ala Asn Leu Pro Ala Pro Phe Phe Thr 
    130                 135                 140                 


Leu Pro Gln Leu Lys Asp Ser Phe Arg Asn Val Gly Leu Asn Arg Ser 
145                 150                 155                 160 


Ser Asp Leu Val Ala Leu Ser Gly Gly His Thr Phe Gly Lys Asn Gln 
                165                 170                 175     


Cys Arg Phe Ile Met Asp Arg Leu Tyr Asn Phe Ser Asn Thr Gly Leu 
            180                 185                 190         


Pro Asp Pro Thr Leu Asn Thr Thr Tyr Leu Gln Thr Leu Arg Gly Leu 
        195                 200                 205             


Cys Pro Leu Asn Gly Asn Leu Ser Ala Leu Val Asp Phe Asp Leu Arg 
    210                 215                 220                 


Thr Pro Thr Ile Phe Asp Asn Lys Tyr Tyr Val Asn Leu Glu Glu Gln 
225                 230                 235                 240 


Lys Gly Leu Ile Gln Ser Asp Gln Glu Leu Phe Ser Ser Pro Asn Ala 
                245                 250                 255     


Thr Asp Thr Ile Pro Leu Val Arg Ser Phe Ala Asn Ser Thr Gln Thr 
            260                 265                 270         


Phe Phe Asn Ala Phe Val Glu Ala Met Asp Arg Met Gly Asn Ile Thr 
        275                 280                 285             


Pro Leu Thr Gly Thr Gln Gly Gln Ile Arg Leu Asn Cys Arg Val Val 
    290                 295                 300                 


Asn Ser 
305     


<210>  24
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 
1               5                   10                  15      


Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly 
            20                  25                  30          


Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly 
        35                  40                  45              


Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe 
    50                  55                  60                  


Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 
65                  70                  75                  80  


Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys 
                85                  90                  95      


Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg 
            100                 105                 110         


Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp 
        115                 120                 125             


Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp 
    130                 135                 140                 


Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 
145                 150                 155                 160 


Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu 
                165                 170                 175     


Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 
        195                 200                 205             


His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn 
    210                 215                 220                 


Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln 
225                 230                 235                 240 


Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly 
            260                 265                 270         


Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln 
        275                 280                 285             


Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro 
    290                 295                 300                 


His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 
305                 310                 315                 320 


Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 
                325                 330                 335     


Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 
            340                 345                 350         


Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro 
        355                 360                 365             


Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 
    370                 375                 380                 


Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 
385                 390                 395                 400 


Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 
                405                 410                 415     


Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 
            420                 425                 430         


Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val 
        435                 440                 445             


Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 
    450                 455                 460                 


Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 
465                 470                 475                 480 


Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 
                485                 490                 495     


Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe 
            500                 505                 510         


Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
        515                 520                 525         


<210>  25
<211>  753
<212>  PRT
<213>  Escherichia coli

<400>  25

Met Ser Gln His Asn Glu Lys Asn Pro His Gln His Gln Ser Pro Leu 
1               5                   10                  15      


His Asp Ser Ser Glu Ala Lys Pro Gly Met Asp Ser Leu Ala Pro Glu 
            20                  25                  30          


Asp Gly Ser His Arg Pro Ala Ala Glu Pro Thr Pro Pro Gly Ala Gln 
        35                  40                  45              


Pro Thr Ala Pro Gly Ser Leu Lys Ala Pro Asp Thr Arg Asn Glu Lys 
    50                  55                  60                  


Leu Asn Ser Leu Glu Asp Val Arg Lys Gly Ser Glu Asn Tyr Ala Leu 
65                  70                  75                  80  


Thr Thr Asn Gln Gly Val Arg Ile Ala Asp Asp Gln Asn Ser Leu Arg 
                85                  90                  95      


Ala Gly Ser Arg Gly Pro Thr Leu Leu Glu Asp Phe Ile Leu Arg Glu 
            100                 105                 110         


Lys Ile Thr His Phe Asp His Glu Arg Ile Pro Glu Arg Ile Val His 
        115                 120                 125             


Ala Arg Gly Ser Ala Ala His Gly Tyr Phe Gln Pro Tyr Lys Ser Leu 
    130                 135                 140                 


Ser Asp Ile Thr Lys Ala Asp Phe Leu Ser Asp Pro Asn Lys Ile Thr 
145                 150                 155                 160 


Pro Val Phe Val Arg Phe Ser Thr Val Gln Gly Gly Ala Gly Ser Ala 
                165                 170                 175     


Asp Thr Val Arg Asp Ile Arg Gly Phe Ala Thr Lys Phe Tyr Thr Glu 
            180                 185                 190         


Glu Gly Ile Phe Asp Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile 
        195                 200                 205             


Gln Asp Ala His Lys Phe Pro Asp Phe Val His Ala Val Lys Pro Glu 
    210                 215                 220                 


Pro His Trp Ala Ile Pro Gln Gly Gln Ser Ala His Asp Thr Phe Trp 
225                 230                 235                 240 


Asp Tyr Val Ser Leu Gln Pro Glu Thr Leu His Asn Val Met Trp Ala 
                245                 250                 255     


Met Ser Asp Arg Gly Ile Pro Arg Ser Tyr Arg Thr Met Glu Gly Phe 
            260                 265                 270         


Gly Ile His Thr Phe Arg Leu Ile Asn Ala Glu Gly Lys Ala Thr Phe 
        275                 280                 285             


Val Arg Phe His Trp Lys Pro Leu Ala Gly Lys Ala Ser Leu Val Trp 
    290                 295                 300                 


Asp Glu Ala Gln Lys Leu Thr Gly Arg Asp Pro Asp Phe His Arg Arg 
305                 310                 315                 320 


Glu Leu Trp Glu Ala Ile Glu Ala Gly Asp Phe Pro Glu Tyr Glu Leu 
                325                 330                 335     


Gly Phe Gln Leu Ile Pro Glu Glu Asp Glu Phe Lys Phe Asp Phe Asp 
            340                 345                 350         


Leu Leu Asp Pro Thr Lys Leu Ile Pro Glu Glu Leu Val Pro Val Gln 
        355                 360                 365             


Arg Val Gly Lys Met Val Leu Asn Arg Asn Pro Asp Asn Phe Phe Ala 
    370                 375                 380                 


Glu Asn Glu Gln Ala Ala Phe His Pro Gly His Ile Val Pro Gly Leu 
385                 390                 395                 400 


Asp Phe Thr Asn Asp Pro Leu Leu Gln Gly Arg Leu Phe Ser Tyr Thr 
                405                 410                 415     


Asp Thr Gln Ile Ser Arg Leu Gly Gly Pro Asn Phe His Glu Ile Pro 
            420                 425                 430         


Ile Asn Arg Pro Thr Cys Pro Tyr His Asn Phe Gln Arg Asp Gly Met 
        435                 440                 445             


His Arg Met Gly Ile Asp Thr Asn Pro Ala Asn Tyr Glu Pro Asn Ser 
    450                 455                 460                 


Ile Asn Asp Asn Trp Pro Arg Glu Thr Pro Pro Gly Pro Lys Arg Gly 
465                 470                 475                 480 


Gly Phe Glu Ser Tyr Gln Glu Arg Val Glu Gly Asn Lys Val Arg Glu 
                485                 490                 495     


Arg Ser Pro Ser Phe Gly Glu Tyr Tyr Ser His Pro Arg Leu Phe Trp 
            500                 505                 510         


Leu Ser Gln Thr Pro Phe Glu Gln Arg His Ile Val Asp Gly Phe Ser 
        515                 520                 525             


Phe Glu Leu Ser Lys Val Val Arg Pro Tyr Ile Arg Glu Arg Val Val 
    530                 535                 540                 


Asp Gln Leu Ala His Ile Asp Leu Thr Leu Ala Gln Ala Val Ala Lys 
545                 550                 555                 560 


Asn Leu Gly Ile Glu Leu Thr Asp Asp Gln Leu Asn Ile Thr Pro Pro 
                565                 570                 575     


Pro Asp Val Asn Gly Leu Lys Lys Asp Pro Ser Leu Ser Leu Tyr Ala 
            580                 585                 590         


Ile Pro Asp Gly Asp Val Lys Gly Arg Val Val Ala Ile Leu Leu Asn 
        595                 600                 605             


Asp Glu Val Arg Ser Ala Asp Leu Leu Ala Ile Leu Lys Ala Leu Lys 
    610                 615                 620                 


Ala Lys Gly Val His Ala Lys Leu Leu Tyr Ser Arg Met Gly Glu Val 
625                 630                 635                 640 


Thr Ala Asp Asp Gly Thr Val Leu Pro Ile Ala Ala Thr Phe Ala Gly 
                645                 650                 655     


Ala Pro Ser Leu Thr Val Asp Ala Val Ile Val Pro Cys Gly Asn Ile 
            660                 665                 670         


Ala Asp Ile Ala Asp Asn Gly Asp Ala Asn Tyr Tyr Leu Met Glu Ala 
        675                 680                 685             


Tyr Lys His Leu Lys Pro Ile Ala Leu Ala Gly Asp Ala Arg Lys Phe 
    690                 695                 700                 


Lys Ala Thr Ile Lys Ile Ala Asp Gln Gly Glu Glu Gly Ile Val Glu 
705                 710                 715                 720 


Ala Asp Ser Ala Asp Gly Ser Phe Met Asp Glu Leu Leu Thr Leu Met 
                725                 730                 735     


Ala Ala His Arg Val Trp Ser Arg Ile Pro Lys Ile Asp Lys Ile Pro 
            740                 745                 750         


Ala 
    


